Database : MEDLINE
Search on : pleuropneumonia [Words]
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[PMID]: 29229731
[Au] Autor:Li B; Fang J; Zuo Z; Yin S; He T; Yang M; Deng J; Shen L; Ma X; Yu S; Wang Y; Ren Z
[Ad] Address:Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan Province, China.
[Ti] Title:Activation of Porcine Alveolar Macrophages by Actinobacillus pleuropneumoniae Lipopolysaccharide via the Toll-Like Receptor 4/NF-κB-Mediated Pathway.
[So] Source:Infect Immun;86(3), 2018 Mar.
[Is] ISSN:1098-5522
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:is the causative agent of porcine contagious pleuropneumonia. Overproduction of proinflammatory cytokines, like interleukin-1ß (IL-1ß), IL-6, tumor necrosis factor alpha, and resistin, in the lung is an important feature of infection. These proinflammatory cytokines enhance inflammatory and immunological responses. However, the mechanism that leads to cytokine production remains unclear. As a major virulence factor of , lipopolysaccharide (LPS) may act as a potent stimulator of Toll-like receptor 4 (TLR4), triggering a number of intracellular signaling pathways that lead to the synthesis of proinflammatory cytokines. Porcine alveolar macrophages (PAMs) are the first line of defense against pathogenic microbes during pathogen invasion. The results of the present study demonstrate that LPS induces PAMs to produce inflammatory cytokines in time- and dose-dependent manners. Moreover, PAMs were activated by LPS, resulting in upregulation of signaling molecules, including TLR4, MyD88, TRIF-related adaptor molecule, and NF-κB. In contrast, the activation effects of LPS on PAMs could be suppressed by specific inhibitors, like small interfering RNA and Bay11-7082. Taken together, our data indicate that LPS can induce PAMs to produce proinflammatory cytokines via the TLR4/NF-κB-mediated pathway. These findings partially reveal the mechanism of the overproduction of proinflammatory cytokines in the lungs of swine with infection and may provide targets for the prevention of -induced pneumonia. All the data could be used as a reference for the pathogenesis of respiratory infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

  2 / 10352 MEDLINE  
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[PMID]: 29373591
[Au] Autor:Xu K; Zhao Q; Wen X; Wu R; Wen Y; Huang X; Huang Y; Yan Q; Han X; Ma X; Chang YF; Cao S
[Ad] Address:Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
[Ti] Title:A trivalent Apx-fusion protein delivered by E. coli outer membrane vesicles induce protection against Actinobacillus pleuropneumoniae of serotype 1 and 7 challenge in a murine model.
[So] Source:PLoS One;13(1):e0191286, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Actinobacillus pleuropneumoniae (APP) causes serious economic losses in the swine industry, and is the etiologic agent of porcine pleuropneumonia. In this study we have engineered a trivalent Apx fusion protein enclosed in outer membrane vesicles (Apxr-OMV) and studied its immunoprotective efficacy against APP serotypes 1 and 7 challenge in mice. The results showed that the IgG levels in the Apxr-OMVs immune group were significantly higher than those of the negative control (P < 0.05). Up-regulation of both Th1 (IFN-γ, IL-2) and Th2 (IL-4) cytokines were detected in splenocytes of Apxr-OMVs immune group. The survival rates 87.5% and 62.5% were observed against APP strain 1516 of serotype 7 and APP strain 2701 of serotype 1 in the groups of Apxr-OMVs immune group, respectively. Histopathological lesions of the pulmonary structure alveoli were found to be minimal in APX-OMV group challenged with APP serotypes 1 and 7. These results strongly indicated that engineered OMVs could effectively induce specific humoral or cellular immune responses. Moreover, Apxr-OMVs used as novel vaccine provides cross-protective immunity against different serotype 1 and 7 of APP infection in a mouse model. In contrast, the OMV-empty and PBS as negative controls or inactivated strain of APP-2701 and APP-1516 as positive controls for the animal study cannot provide protection or cross-protection.
[Mh] MeSH terms primary: Actinobacillus pleuropneumoniae/physiology
Bacterial Vaccines/immunology
Cell Membrane/metabolism
Escherichia coli/cytology
Escherichia coli/genetics
Protein Engineering
Recombinant Fusion Proteins/immunology
[Mh] MeSH terms secundary: Actinobacillus pleuropneumoniae/immunology
Animals
Bacterial Vaccines/genetics
Cell Proliferation
Cytokines/metabolism
Female
Immunity, Cellular
Lymphocytes/cytology
Mice
Mice, Inbred BALB C
Recombinant Fusion Proteins/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Bacterial Vaccines); 0 (Cytokines); 0 (Recombinant Fusion Proteins)
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[Js] Journal subset:IM
[Da] Date of entry for processing:180127
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191286

  3 / 10352 MEDLINE  
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[PMID]: 29329577
[Au] Autor:Di Teodoro G; Marruchella G; Di Provvido A; Orsini G; Ronchi GF; D'Angelo AR; D'Alterio N; Sacchini F; Scacchia M
[Ad] Address:OIE Reference Laboratory for Contagious Bovine Pleuropneumonia, Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise "G. Caporale", Campo Boario, 64100, Teramo, Italy.
[Ti] Title:Respiratory explants as a model to investigate early events of contagious bovine pleuropneumonia infection.
[So] Source:Vet Res;49(1):5, 2018 Jan 12.
[Is] ISSN:1297-9716
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Contagious bovine pleuropneumonia (CBPP) is a severe disease caused by Mycoplasma mycoides subsp. mycoides (Mmm). Knowledge on CBPP pathogenesis is fragmented and hampered by the limited availability of laboratory animal and in vitro models of investigation. The purpose of the present study is to assess respiratory explants as useful tools to study the early stages of CBPP. Explants were obtained from trachea, bronchi and lungs of slaughtered cattle, tested negative for Mycoplasma spp. and for the major bacterial and viral respiratory pathogens. The interaction of Mmm with explant cells was studied by immunohistochemistry (IHC), double-labelling indirect immunofluorescence (DLIIF) and laser scanning confocal microscopy (LSCM). Mmm capability to survive and proliferate within the explants was evaluated by standard microbiological procedures. Finally, the putative cellular internalization of Mmm was further investigated by the gentamicin invasion assay. IHC and DLIIF indicated that Mmm can colonize explants, showing a marked tropism for lower airways. Specifically, Mmm was detected on/inside the bronchiolar and alveolar epithelial cells, the alveolar macrophages and the endothelial cells. The interaction between Mmm and explant cells was abolished by the pre-incubation of the pathogen with bovine anti-Mmm immune sera. Mmm was able to survive and proliferate in all tracheal, bronchial and lung explants, during the entire time course of the experiments. LSCM and gentamicin invasion assay both confirmed that Mmm can enter non-phagocytic host cells. Taken together, our data supports bovine respiratory explants as a promising tool to investigate CBPP, alternative to cattle experimental infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180210
[Lr] Last revision date:180210
[St] Status:In-Data-Review
[do] DOI:10.1186/s13567-017-0500-z

  4 / 10352 MEDLINE  
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[PMID]: 29316978
[Au] Autor:Antenucci F; Fougeroux C; Deeney A; Ørskov C; Rycroft A; Holst PJ; Bojesen AM
[Ad] Address:Department of Veterinary and Animal Sciences, University of Copenhagen, Stigbøjlen 4, 1870 Frb. C., 1-20, Building: 301, Copenhagen, Denmark.
[Ti] Title:In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae.
[So] Source:Vet Res;49(1):4, 2018 Jan 09.
[Is] ISSN:1297-9716
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is a Gram-negative bacterium that represents the main cause of porcine pleuropneumonia in pigs, causing significant economic losses to the livestock industry worldwide. A. pleuropneumoniae, as the majority of Gram-negative bacteria, excrete vesicles from its outer membrane (OM), accordingly defined as outer membrane vesicles (OMVs). Thanks to their antigenic similarity to the OM, OMVs have emerged as a promising tool in vaccinology. In this study we describe the in vivo testing of several vaccine prototypes for the prevention of infection by all known A. pleuropneumoniae serotypes. Previously identified vaccine candidates, the recombinant proteins ApfA and VacJ, administered individually or in various combinations with the OMVs, were employed as vaccination strategies. Our data show that the addition of the OMVs in the vaccine formulations significantly increased the specific IgG titer against both ApfA and VacJ in the immunized animals, confirming the previously postulated potential of the OMVs as adjuvant. Unfortunately, the antibody response raised did not translate into an effective protection against A. pleuropneumoniae infection, as none of the immunized groups following challenge showed a significantly lower degree of lesions than the controls. Interestingly, quite the opposite was true, as the animals with the highest IgG titers were also the ones bearing the most extensive lesions in their lungs. These results shed new light on A. pleuropneumoniae pathogenicity, suggesting that antibody-mediated cytotoxicity from the host immune response may play a central role in the development of the lesions typically associated with A. pleuropneumoniae infections.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180117
[Lr] Last revision date:180117
[St] Status:In-Data-Review
[do] DOI:10.1186/s13567-017-0502-x

  5 / 10352 MEDLINE  
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[PMID]: 29290302
[Au] Autor:Suleiman A; Jackson E; Rushton J
[Ad] Address:Veterinary Epidemiology, Economics and Public Health Group, Royal Veterinary College, University of London, AL9 7TA, United Kingdom; Department of Veterinary Public Health and Preventive Medicine, Ahmadu Bello University, Main Campus, Zaria, Nigeria; National Consultant Livestock Livelihoods, Food and Agriculture Organization of the United Nations, 7B Government House Road, Old GRA, Maiduguri, Nigeria. Electronic address: abubakarsuleiman@abu.edu.ng.
[Ti] Title:Perceptions, circumstances and motivators affecting the implementation of contagious bovine pleuropneumonia control programmes in Nigerian Fulani pastoral herds.
[So] Source:Prev Vet Med;149:67-74, 2018 Jan 01.
[Is] ISSN:1873-1716
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Contagious bovine pleuropneumonia (CBPP) is an infectious disease of cattle which substantially contributes to poor productivity of the sub-Saharan pastoral livestock sector. In Nigeria and most of the West African countries, limited public funding for CBPP control have necessitated farmers to bear a bigger burden of managing the disease. Understanding the factors influencing decision of farmers to implement disease control programmes is therefore a key element in informing future policies aimed at improving CBPP management. This study explored perceptions of Nigerian Fulani pastoral herdsmen on the responsibility for cattle healthcare, and identified their circumstances and motivations in implementing CBPP management programmes. Field data were collected from 191 pastoral farmers using a semi-structured, interviewer-administered questionnaire. The results indicated that younger farmers were more likely than their older counterpart to accept the responsibility for CBPP management (p<0.01). This may signal future prospects for improved CBPP management where upcoming farmers could be encouraged to implement CBPP control programmes and uphold the costs. 13.6% of the farmers had no intention of implementing any CBPP control programme on farm, while 81.2% either had a positive intention or implemented at least one programme aimed at controlling CBPP. Intention to implement CBPP control programmes was significantly associated with educational attainment of farmers (p<0.01) and their access to CBPP control services offered by trained veterinarians (p<0.01). Farmers with negative attitudes towards implementing CBPP control programmes could be motivated to change their perspectives by advice from trusted sources and improved access to veterinary services. Conversely, farmers with positive attitudes towards implementing CBPP control programmes were more likely to be motivated by affordable veterinary services and advocacy on specific CBPP control programmes. As such, the former group of farmers will be more likely to benefit from programmes which focus on providing credible information from trusted sources, such as extension agents, veterinarians or successful peers. On the contrary, interventions targeting the latter group of farmers should prioritize cost-effective delivery of improved CBPP control technologies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180101
[Lr] Last revision date:180101
[St] Status:In-Process

  6 / 10352 MEDLINE  
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[PMID]: 29122004
[Au] Autor:Antenucci F; Fougeroux C; Bossé JT; Magnowska Z; Roesch C; Langford P; Holst PJ; Bojesen AM
[Ad] Address:Department of Veterinary and Animal Sciences, University of Copenhagen, Stigbøjlen 4, 1870 Frb. C., 1-20, Building: 301, Copenhagen, Denmark.
[Ti] Title:Identification and characterization of serovar-independent immunogens in Actinobacillus pleuropneumoniae.
[So] Source:Vet Res;48(1):74, 2017 Nov 09.
[Is] ISSN:1297-9716
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Despite numerous actions to prevent disease, Actinobacillus pleuropneumoniae (A. pleuropneumoniae) remains a major cause of porcine pleuropneumonia, resulting in economic losses to the swine industry worldwide. In this paper, we describe the utilization of a reverse vaccinology approach for the selection and in vitro testing of serovar-independent A. pleuropneumoniae immunogens. Potential immunogens were identified in the complete genomes of three A. pleuropneumoniae strains belonging to different serovars using the following parameters: predicted outer-membrane subcellular localization; ≤ 1 trans-membrane helices; presence of a signal peptide in the protein sequence; presence in all known A. pleuropneumoniae genomes; homology with other well characterized factors with relevant data regarding immunogenicity/protective potential. Using this approach, we selected the proteins ApfA and VacJ to be expressed and further characterized, both in silico and in vitro. Additionally, we analysed outer membrane vesicles (OMVs) of A. pleuropneumoniae MIDG2331 as potential immunogens, and compared deletions in degS and nlpI for increasing yields of OMVs compared to the parental strain. Our results indicated that ApfA and VacJ are highly conserved proteins, naturally expressed during infection by all A. pleuropneumoniae serovars tested. Furthermore, OMVs, ApfA and VacJ were shown to possess a high immunogenic potential in vitro. These findings favour the immunogen selection protocol used, and suggest that OMVs, along with ApfA and VacJ, could represent effective immunogens for the prevention of A. pleuropneumoniae infections in a serovar-independent manner. This hypothesis is nonetheless predictive in nature, and in vivo testing in a relevant animal model will be necessary to verify its validity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171119
[Lr] Last revision date:171119
[St] Status:In-Process
[do] DOI:10.1186/s13567-017-0479-5

  7 / 10352 MEDLINE  
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[PMID]: 29110751
[Au] Autor:Hathroubi S; Loera-Muro A; Guerrero-Barrera AL; Tremblay YDN; Jacques M
[Ad] Address:Department of Microbiology and Environmental Toxicology,University of California,Santa Cruz, CA,USA.
[Ti] Title:Actinobacillus pleuropneumoniae biofilms: Role in pathogenicity and potential impact for vaccination development.
[So] Source:Anim Health Res Rev;:1-14, 2017 Nov 07.
[Is] ISSN:1475-2654
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Actinobacillus pleuropneumoniae is a Gram-negative bacterium that belongs to the family Pasteurellaceae. It is the causative agent of porcine pleuropneumonia, a highly contagious respiratory disease that is responsible for major economic losses in the global pork industry. The disease may present itself as a chronic or an acute infection characterized by severe pathology, including hemorrhage, fibrinous and necrotic lung lesions, and, in the worst cases, rapid death. A. pleuropneumoniae is transmitted via aerosol route, direct contact with infected pigs, and by the farm environment. Many virulence factors associated with this bacterium are well characterized. However, much less is known about the role of biofilm, a sessile mode of growth that may have a critical impact on A. pleuropneumoniae pathogenicity. Here we review the current knowledge on A. pleuropneumoniae biofilm, factors associated with biofilm formation and dispersion, and the impact of biofilm on the pathogenesis A. pleuropneumoniae. We also provide an overview of current vaccination strategies against A. pleuropneumoniae and consider the possible role of biofilms vaccines for controlling the disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[St] Status:Publisher
[do] DOI:10.1017/S146625231700010X

  8 / 10352 MEDLINE  
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[PMID]: 29083117
[Au] Autor:Sassu EL; Bossé JT; Tobias TJ; Gottschalk M; Langford PR; Hennig-Pauka I
[Ad] Address:Department of Pathobiology, Institute of Immunology, University of Veterinary Medicine, Vienna, Austria.
[Ti] Title:Update on Actinobacillus pleuropneumoniae-knowledge, gaps and challenges.
[So] Source:Transbound Emerg Dis;, 2017 Oct 30.
[Is] ISSN:1865-1682
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Porcine pleuropneumonia, caused by the bacterial porcine respiratory tract pathogen Actinobacillus pleuropneumoniae, leads to high economic losses in affected swine herds in most countries of the world. Pigs affected by peracute and acute disease suffer from severe respiratory distress with high lethality. The agent was first described in 1957 and, since then, knowledge about the pathogen itself, and its interactions with the host, has increased continuously. This is, in part, due to the fact that experimental infections can be studied in the natural host. However, the fact that most commercial pigs are colonized by this pathogen has hampered the applicability of knowledge gained under experimental conditions. In addition, several factors are involved in development of disease, and these have often been studied individually. In a DISCONTOOLS initiative, members from science, industry and clinics exchanged their expertise and empirical observations and identified the major gaps in knowledge. This review sums up published results and expert opinions, within the fields of pathogenesis, epidemiology, transmission, immune response to infection, as well as the main means of prevention, detection and control. The gaps that still remain to be filled are highlighted, and present as well as future challenges in the control of this disease are addressed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[St] Status:Publisher
[do] DOI:10.1111/tbed.12739

  9 / 10352 MEDLINE  
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[PMID]: 29081918
[Au] Autor:Torsson E; Berg M; Misinzo G; Herbe I; Kgotlele T; Päärni M; Roos N; Blomström AL; Ståhl K; Johansson Wensman J
[Ad] Address:Department of Biomedical Sciences & Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.
[Ti] Title:Seroprevalence and risk factors for peste des petits ruminants and selected differential diagnosis in sheep and goats in Tanzania.
[So] Source:Infect Ecol Epidemiol;7(1):1368336, 2017.
[Is] ISSN:2000-8686
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Livestock husbandry is critical for food security and poverty reduction in a low-income country like Tanzania. Infectious disease is one of the major constraints reducing the productivity in this sector. Peste des petits ruminants (PPR) is one of the most important diseases affecting small ruminants, but other infectious diseases may also be present. The objective of this study was to determine the seroprevalence and risk factors for exposure to PPR, contagious caprine pleuropneumonia (CCPP), foot-and-mouth disease (FMD), bluetongue (BT), and bovine viral diarrhoea (BVD) in sheep and goats in Tanzania. Serum samples were collected in 2014 and 2015, and analysed using enzyme-linked immunosorbent assays to detect antibodies to the five pathogens. This is the first description of seroprevalence of FMD and BT among small ruminants in Tanzania. Risk factor analysis identified sex (female) (OR for 2014: PPR: 2.49, CCPP: 3.11, FMD: 2.98, BT: 12.4, OR for 2015: PPR: 14.1, CCPP: 1.10, FMD: 2.67, BT: 1.90, BVD: 4.73) and increasing age (>2 years) (OR for 2014: PPR: 14.9, CCPP: 2.34, FMD: 7.52, BT: 126, OR for 2015: PPR: 8.13, CCPP: 1.11, FMD: 2.98, BT: 7.83, BVD: 4.74) as risk factors for exposure to these diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1080/20008686.2017.1368336

  10 / 10352 MEDLINE  
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[PMID]: 29030504
[Ti] Title:SAC C VS disease surveillance, June 2017.
[So] Source:Vet Rec;181(15):362-365, 2017 Oct 14.
[Is] ISSN:2042-7670
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Shortened limbs in pedigree Aberdeen Angus calvesSpinal listeriosis in a suckled calfTickborne fever in lambs pleuropneumonia in finishing pigsThese are among matters discussed in the disease surveillance report for June 2017 from SAC Consulting: Veterinary Services (SAC C VS).
[Mh] MeSH terms primary: Animal Diseases/epidemiology
Disease Outbreaks/veterinary
Sentinel Surveillance/veterinary
[Mh] MeSH terms secundary: Animals
Bird Diseases/epidemiology
Birds
Cattle
Cattle Diseases/epidemiology
Female
Otters
Poultry
Poultry Diseases/epidemiology
Pregnancy
Scotland/epidemiology
Sheep
Sheep Diseases/epidemiology
Swine
Swine Diseases/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171018
[Lr] Last revision date:171018
[Js] Journal subset:IM
[Da] Date of entry for processing:171015
[St] Status:MEDLINE
[do] DOI:10.1136/vr.j4583


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