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Search on : potassium and iodide [Words]
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[PMID]: 29184999
[Au] Autor:Oya M; Suzuki H; Anas ARJ; Oishi K; Ono K; Yamaguchi S; Eguchi M; Sawada M
[Ad] Address:Department of Brain Function, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8601, Japan.
[Ti] Title:LC-MS/MS imaging with thermal film-based laser microdissection.
[So] Source:Anal Bioanal Chem;410(2):491-499, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Mass spectrometry (MS) imaging is a useful tool for direct and simultaneous visualization of specific molecules. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used to evaluate the abundance of molecules in tissues using sample homogenates. To date, however, LC-MS/MS has not been utilized as an imaging tool because spatial information is lost during sample preparation. Here we report a new approach for LC-MS/MS imaging using a thermal film-based laser microdissection (LMD) technique. To isolate tissue spots, our LMD system uses a 808-nm near infrared laser, the diameter of which can be freely changed from 2.7 to 500 µm; for imaging purposes in this study, the diameter was fixed at 40 µm, allowing acquisition of LC-MS/MS images at a 40-µm resolution. The isolated spots are arranged on a thermal film at 4.5-mm intervals, corresponding to the well spacing on a 384-well plate. Each tissue spot is handled on the film in such a manner as to maintain its spatial information, allowing it to be extracted separately in its individual well. Using analytical LC-MS/MS in combination with the spatial information of each sample, we can reconstruct LC-MS/MS images. With this imaging technique, we successfully obtained the distributions of pilocarpine, glutamate, γ-aminobutyric acid, acetylcholine, and choline in a cross-section of mouse hippocampus. The protocol we established in this study is applicable to revealing the neurochemistry of pilocarpine model of epilepsy. Our system has a wide range of uses in fields such as biology, pharmacology, pathology, and neuroscience. Graphical abstract Schematic Indication of LMD-LC-MS/MS imaging.
[Mh] MeSH terms primary: Hippocampus/chemistry
Laser Capture Microdissection/methods
Neurotransmitter Agents/analysis
Tandem Mass Spectrometry/methods
[Mh] MeSH terms secundary: Acetylcholine/analysis
Animals
Choline/analysis
Chromatography, Liquid/methods
Epilepsy/diagnosis
Epilepsy/pathology
Female
Glutamic Acid/analysis
Hippocampus/pathology
Mice, Inbred C57BL
Pilocarpine/analysis
gamma-Aminobutyric Acid/analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Neurotransmitter Agents); 01MI4Q9DI3 (Pilocarpine); 3KX376GY7L (Glutamic Acid); 56-12-2 (gamma-Aminobutyric Acid); N91BDP6H0X (Choline); N9YNS0M02X (Acetylcholine)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:171130
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0739-2

  2 / 13512 MEDLINE  
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[PMID]: 28462392
[Au] Autor:Li WC; Zhu XY; Ritson E
[Ad] Address:University of St Andrews, St Andrews, Fife KY16 9JP, Scotland.
[Ti] Title:Mechanosensory Stimulation Evokes Acute Concussion-Like Behavior by Activating GIRKs Coupled to Muscarinic Receptors in a Simple Vertebrate.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Most vertebrates show concussion responses when their heads are hit suddenly by heavy objects. Previous studies have focused on the direct physical injuries to the neural tissue caused by the concussive blow. We study a similar behavior in a simple vertebrate, the tadpole. We find that concussion-like behavior can be reliably induced by the mechanosensory stimulation of the head skin without direct physical impacts on the brain. Head skin stimulation activates a cholinergic pathway which then opens G protein-coupled inward-rectifying potassium channels (GIRKs) via postsynaptic M muscarinic receptors to inhibit brainstem neurons critical for the initiation and maintenance of swimming for up to minutes and can explain many features commonly observed immediately after concussion. We propose that some acute symptoms of concussion in vertebrates can be explained by the opening of GIRKs following mechanosensory stimulation to the head.
[Mh] MeSH terms primary: Acetylcholine/metabolism
G Protein-Coupled Inwardly-Rectifying Potassium Channels/metabolism
Neurons/metabolism
Receptors, Muscarinic/metabolism
[Mh] MeSH terms secundary: Animals
Brain Concussion/metabolism
Brain Stem/metabolism
Humans
Oocytes/metabolism
Vertebrates/metabolism
Xenopus laevis/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (G Protein-Coupled Inwardly-Rectifying Potassium Channels); 0 (Receptors, Muscarinic); N9YNS0M02X (Acetylcholine)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:170503
[St] Status:MEDLINE

  3 / 13512 MEDLINE  
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[PMID]: 29516561
[Au] Autor:Jayaramulu K; Dubal DP; Nagar B; Ranc V; Tomanec O; Petr M; Datta KKR; Zboril R; Gómez-Romero P; Fischer RA
[Ad] Address:Chair of Inorganic and Metal-Organic Chemistry, Department of Chemistry and Catalysis Research Centre, Technical University of Munich, 85748, Garching, Germany.
[Ti] Title:Ultrathin Hierarchical Porous Carbon Nanosheets for High-Performance Supercapacitors and Redox Electrolyte Energy Storage.
[So] Source:Adv Mater;, 2018 Mar 08.
[Is] ISSN:1521-4095
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The design of advanced high-energy-density supercapacitors requires the design of unique materials that combine hierarchical nanoporous structures with high surface area to facilitate ion transport and excellent electrolyte permeability. Here, shape-controlled 2D nanoporous carbon sheets (NPSs) with graphitic wall structure through the pyrolysis of metal-organic frameworks (MOFs) are developed. As a proof-of-concept application, the obtained NPSs are used as the electrode material for a supercapacitor. The carbon-sheet-based symmetric cell shows an ultrahigh Brunauer-Emmett-Teller (BET)-area-normalized capacitance of 21.4 µF cm (233 F g ), exceeding other carbon-based supercapacitors. The addition of potassium iodide as redox-active species in a sulfuric acid (supporting electrolyte) leads to the ground-breaking enhancement in the energy density up to 90 Wh kg , which is higher than commercial aqueous rechargeable batteries, maintaining its superior power density. Thus, the new material provides a double profits strategy such as battery-level energy and capacitor-level power density.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1002/adma.201705789

  4 / 13512 MEDLINE  
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[PMID]: 29461552
[Au] Autor:Jiang Y; Zou JX; Huang LT; Peng X; Deng JD; Zhu LQ; Yang YH; Feng YY; Zhang XY; Wang Z
[Ad] Address:School of Pharmacy, Lanzhou University, West Donggang Road. No. 199, Lanzhou 730000, China. pharmacyzxy@163.com zhenw@lzu.edu.cn.
[Ti] Title:KI-catalyzed C-S bond formation via an oxidation relay strategy: efficient access to various α-thio-ß-dicarbonyl compounds.
[So] Source:Org Biomol Chem;16(10):1641-1645, 2018 Mar 07.
[Is] ISSN:1477-0539
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:An efficient and practical methodology to obtain α-thio-ß-dicarbonyl compounds was presented under alkaline conditions via potassium iodide (KI) catalysis; various symmetrical/unsymmetrical 1,3-dicarbonyl compounds were obtained under an aerobic atmosphere in moderate to excellent yields, with good functional group tolerance. Notably, a widely used anti-inflammatory drug butazodine could be modified with our protocol, even on a gram scale.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1039/c8ob00080h

  5 / 13512 MEDLINE  
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[PMID]: 29503480
[Au] Autor:Ansari NH; Söderberg BCG
[Ad] Address:C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506-6045, United States.
[Ti] Title:Synthesis of -alkoxy-substituted 2 -benzimidazoles.
[So] Source:Tetrahedron Lett;58(50):4717-4720, 2017 Dec 13.
[Is] ISSN:0040-4039
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Treatment of 2-nitro- -(2-methyl-1-propen-1-yl)benzenamines with potassium -butoxide in -butanol followed by the addition of an electrophile affords -alkoxy-2 -benzimidazoles. Electrophiles including methyl iodide, allylic bromides, propargylic bromides, benzyl bromide, and acetyl chloride gave good to excellent yields of product while 1-iodo- and 2-iodo-butane afforded very low yields.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review
[do] DOI:10.1016/j.tetlet.2017.11.007

  6 / 13512 MEDLINE  
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[PMID]: 29504556
[Au] Autor:Döring C; Sui Z; Jones PG
[Ad] Address:Institute of Inorganic and Analytical Chemistry, Technical University of Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany.
[Ti] Title:3,4-Lutidinium salts with the diiodidoaurate(I) anion: structure of [(3,4-lut) H] ·[AuI ] and of two polymorphs of [(3,4-lut) H ] ·[AuI ] ·I .
[So] Source:Acta Crystallogr C Struct Chem;74(Pt 3):289-294, 2018 Mar 01.
[Is] ISSN:2053-2296
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Reactions between potassium tetraiodidoaurate(III) and pyridine (py, C H N) or 3,4-lutidine (3,4-dimethylpyridine, 3,4-lut, C H N) were tested as possible sources of azaaromatic complexes of gold(III) iodide, but all identifiable products contained gold(I). The previously known structure dipyridinegold(I) diiodidoaurate(I), [Au(py) ] ·[AuI ] , (3) [Adams et al. (1982). Z. Anorg. Allg. Chem. 485, 81-91], was redetermined at 100 K. The reactions with 3,4-lutidine gave three different types of crystal in small quantities. 3,4-Dimethylpyridine-3,4-dimethylpyridinium diiodidoaurate(I), [(3,4-lut) H] ·[AuI ] , (1), consists of an [AuI ] anion on a general position and two [(3,4-lut) H] cations across twofold axes. Bis(3,4-dimethylpyridine-3,4-dimethylpyridinium) diiodidoaurate(I) iodide, [(3,4-lut) H ] ·[AuI ] ·I , (2), crystallizes as two polymorphs, each forming pseudosymmetric inversion twins, in the space groups P2 and Pc (but resembling P2 /m and P2/c), respectively. These are essentially identical layer structures differing only in their stacking patterns and thus might be regarded as polytypes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Data-Review
[do] DOI:10.1107/S2053229618002218

  7 / 13512 MEDLINE  
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[PMID]: 29477891
[Au] Autor:Khan Z; Al-Thabaiti SA
[Ad] Address:Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia. Electronic address: zkkhan@kau.edu.sa.
[Ti] Title:Green synthesis of zero-valent Fe-nanoparticles: Catalytic degradation of rhodamine B, interactions with bovine serum albumin and their enhanced antimicrobial activities.
[So] Source:J Photochem Photobiol B;180:259-267, 2018 Mar.
[Is] ISSN:1873-2682
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Biomimetic method was used for the synthesis of Fe-nanoparticles (FeNPs). FeCl and Hibiscus sabdariffa, Roselle flower aqueous extract (HBS) were employed in the present studies. The FeNPs have been characterized by using UV-visible spectroscopy, transmission electron microscope (TEM), and energy dispersion X-ray spectroscopy (EDS). The average particles diameter was found to be 18 nm. The as prepared FeNPs were used as a catalyst to the oxidative degradation of rhodamine B (RB) in presence of NaBH . The effects of various quencher on the degradation rates were examined by employing ammonium oxalate (AO), benzoquinone (BQ), isopropyl alcohol (IPA), and potassium iodide (KI). The interactions of FeNPs with bovine serum albumin (BSA) have been determined and discussed. Adsorption of FeNPs into the core of BSA changes the tryptophan environment from hydrophobic to hydrophilic (from folding to partially folded and/or unfolded). Tryptophan residues, indole moieties of BSA were responsible to complex formation with FeNPs in excited states via electrostatic, van der Waals, hydrogen bonding, hydrophobic and hydrophilic interactions with static quenching. The antimicrobial activities of FeNPs have been determined against human pathogens. Hibiscus sabdariffa flower extract shows mild antimicrobial activities against all target pathogenic organisms. FeNPs have potential antimicrobial activity against both bacterial strains and candida fungus even at low concentration, and retains potential application in biomedical industries.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process

  8 / 13512 MEDLINE  
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[PMID]: 29438799
[Au] Autor:Wang W; Liu D; Xiao Q; Cai J; Feng N; Xu S; Wang L; Yin D; Wang X
[Ad] Address:State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
[Ti] Title:Lig4-4 selectively inhibits TREK-1 and plays potent neuroprotective roles in vitro and in rat MCAO model.
[So] Source:Neurosci Lett;671:93-98, 2018 Feb 10.
[Is] ISSN:1872-7972
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Two-pore domain potassium channel TREK-1 was known to play an important role in neuroprotection, especially in acute cerebral ischemia. In the present study we found that 3-(nitromethyl) isobenzofuran-1(3H)-one (lig4-4) could robustly inhibit TREK-1 currents with an IC of 2.06 µM. However, the IC of lig4-4 for other ion channel subtypes such as Kv2.1, Kv1.5, Kv3.1, hERG and neuronal Na and Ca channels were more than 30 µM, suggesting a specific inhibition of TREK-1 channel. MTT assay showed that lig4-4 significantly enhanced cell viability of cultured neurons under the condition of oxygen and glucose deprivation followed by reoxygenation (OGD/R). Annexin V/Propidium Iodide apoptosis assay also demonstrated that lig4-4 obviously reduced cell apoptosis in OGD/R-injured neurons. Western blotting results indicated that OGD/R-induced up-regulation of cleaved-caspase-3 expression and down-regulation of Bcl-2 could be notably reversed by lig4-4. The in vivo study showed that after oral administration of lig4-4 at 50 mg/kg, the infarct volume in middle cerebral artery occlusion (MCAO) rat model reduced from a vehicle control of 38.8% to 28%. Both in vitro and in vivo studies suggested that inhibition of TREK-1 with lig4-4 might produce a neuroprotective effect against cerebral ischemia. In conclusion, we demonstrated that lig4-4 selectively inhibited TREK-1 and protected brain from cerebral ischemic injury. The mechanisms might relate to block TREK-1 and inhibit neuronal apoptosis by modulating the expressions of Bcl-2 and cleaved-caspase-3.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher

  9 / 13512 MEDLINE  
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[PMID]: 29487360
[Au] Autor:Aslam R; Mobin M; Aslam J; Lgaz H
[Ad] Address:Corrosion Research Laboratory, Department of Applied Chemistry, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, 202002, India.
[Ti] Title:Sugar based N,N'-didodecyl-N,N'digluconamideethylenediamine gemini surfactant as corrosion inhibitor for mild steel in 3.5% NaCl solution-effect of synergistic KI additive.
[So] Source:Sci Rep;8(1):3690, 2018 Feb 27.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The inhibitory behaviour of non-ionic sugar based N,N'-didodecyl-N,N'-digluconamideethylenediamine gemini surfactant, designated as Glu(12)-2-Glu(12) on mild steel (MS) corrosion in 3.5% NaCl at 30-60 °C was explored using weight loss, PDP, EIS and SEM/EDAX/AFM techniques. The compound inhibited the corrosion of mild steel in 3.5% NaCl and the extent of inhibition was dependent on concentration and temperature. The inhibiting action of Glu(12)-2-Glu(12) is synergistically enhanced on addition of potassium iodide (KI) at all concentrations and temperatures. The inhibiting formulation comprising of 2.5 × 10 mM of Glu(12)-2-Glu(12) and 10 mM of KI exhibits an inhibition efficiency of 96.9% at 60 °C. Quantum chemical calculations and MD simulation were applied to analyze the experimental data and elucidate the adsorption behaviour and inhibition mechanism of inhibitors. MD simulation showed a nearly parallel or flat disposition for Glu(12)-2-Glu(12) molecules on the MS surface providing larger blocking area to prevent the metal surface from corrosion.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-21175-6

  10 / 13512 MEDLINE  
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[PMID]: 29496566
[Au] Autor:Lebsir D; Manens L; Grison S; Lestaevel P; Ebrahimian T; Suhard D; Phan G; Dublineau I; Tack K; Benderitter M; Pech A; Jourdain JR; Souidi M
[Ad] Address:Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, 92262 Fontenay-aux-Roses, France.
[Ti] Title:Effects of repeated potassium iodide administration on genes involved in synthesis and secretion of thyroid hormone in adult male rat.
[So] Source:Mol Cell Endocrinol;, 2018 Feb 26.
[Is] ISSN:1872-8057
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:BACKGROUND: A single dose of potassium iodide (KI) is recommended to reduce the risk of thyroid cancer during nuclear accidents. However in case of prolonged radioiodine exposure, more than one dose of KI may be necessary. This work aims to evaluate the potential toxic effect of repeated administration of KI. METHODS: Adult Wistar rats received an optimal dose of KI 1 mg/kg over a period of 1, 4 or 8 days. RESULTS: hormonal status (TSH, FT4) of treated rats was unaffected. Contrariwise, a sequential Wolff-Chaikoff effect was observed, resulting in a prompt decrease of NIS and MCT8 mRNA expression (-58% and -26% respectively), followed by a delayed decrease of TPO mRNA expression (-33%) in conjunction with a stimulation of PDS mRNA expression (+62%). CONCLUSION: we show for the first time that repeated administration of KI at 1 mg/kg/24h doesn't cause modification of thyroid hormones level, but leads to a reversible modification of the expression of genes involved in the synthesis and secretion of thyroid hormones.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher


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