Database : MEDLINE
Search on : priapism [Words]
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[PMID]: 29508322
[Au] Autor:Marcon J; Stief CG; Becker A
[Ad] Address:Urolog. Klinik und Poliklinik der Ludwig-Maximilians-Univ. München, Marchioninistr. 15, D-81377, München, Deutschland. julian.marcon@med.uni-muenchen.de.
[Ti] Title:Priapismus. [Priapism].
[So] Source:MMW Fortschr Med;160(4):44, 2018 Mar.
[Is] ISSN:1613-3560
[Cp] Country of publication:Germany
[La] Language:ger
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Data-Review
[do] DOI:10.1007/s15006-018-0244-3

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[PMID]: 28470719
[Au] Autor:Ballas SK
[Ad] Address:Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
[Ti] Title:From total blood exchange to erythrocytapheresis and back to treat complications of sickle cell disease.
[So] Source:Transfusion;57(9):2277-2280, 2017 09.
[Is] ISSN:1537-2995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Erythrocytapheresis is an important procedure in the management of certain complications of sickle cell disease, including acute stroke, stroke prevention, acute chest syndrome, and multiorgan failure. Erythrocytapheresis in sickle cell disease simply entails the removal of the patient's red blood cells containing the abnormal sickle hemoglobin and replacing them with normal red blood cells carrying normal hemoglobin. In these procedures, the patient's plasma is not exchanged but is returned to the patient. Several studies have demonstrated that the plasma of patients with sickle cell disease contains several components that increase blood viscosity and initiate or promote vaso-occlusion. These factors include increased levels of globulins, especially immunoglobulin G, acute-phase reactants, fibrinogen, coagulation factors, inflammatory mediators, and heme in the steady state and increase further during painful crises. This may explain why, in certain complications of sickle cell disease, such as acute chest syndrome, hepatic crisis, and priapism, erythrocytapheresis by itself may not be effective despite repetitive cycles of red blood cell exchange. The use of therapeutic plasma exchange in addition to erythrocytapheresis in these situations seems to be useful in resolving them more efficiently. The role of therapeutic plasma exchange in the management of certain complications of sickle cell disease needs further evaluation. This commentary addresses the role of therapeutic plasma exchange in the management of complications of sickle cell disease.
[Mh] MeSH terms primary: Anemia, Sickle Cell/therapy
Cytapheresis/methods
Exchange Transfusion, Whole Blood/methods
[Mh] MeSH terms secundary: Anemia, Sickle Cell/complications
Blood Viscosity
Disease Management
Erythrocytes
Humans
Plasma Exchange/methods
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1710
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:170505
[St] Status:MEDLINE
[do] DOI:10.1111/trf.14154

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[PMID]: 29394072
[Au] Autor:La Favor JD; Fu Z; Venkatraman V; Bivalacqua TJ; Van Eyk JE; Burnett AL
[Ti] Title:Molecular Profile of Priapism Associated with Low Nitric Oxide Bioavailability.
[So] Source:J Proteome Res;17(3):1031-1040, 2018 Mar 02.
[Is] ISSN:1535-3907
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Priapism is a disorder in which prolonged penile erection persists uncontrollably, potentially leading to tissue damage. Priapism commonly afflicts patient populations with severely low nitric oxide (NO) bioavailability. Because NO is a primary mediator of erection, the molecular mechanisms involved in priapism pathophysiology associated with low NO bioavailability are not well-understood. The objective of this study was to identify dysregulated molecular targets and signaling pathways in penile tissue of a mouse model of low NO bioavailability that have potential relevance to priapism. Neuronal plus endothelial NO synthase double knockout mice (NOS1/3 ) were used as a model of low NO bioavailability. Priapic-like activity was demonstrated in the NOS1/3 mice relative to wild-type (WT) mice by the measurement of prolonged erections following cessation of electrical stimulation of the cavernous nerve. Penile tissue was processed and analyzed by reverse-phase liquid chromatography tandem mass spectrometry. As a result, 1279 total proteins were identified and quantified by spectral counting, 46 of which were down-regulated and 110 of which were up-regulated in NOS1/3 versus WT (P < 0.05). Ingenuity Pathway Analysis of differentially expressed proteins revealed increased protein kinase A and G-protein coupled receptor signaling in NOS1/3 penises, which represent potential mechanisms contributing to priapism for secondary to low NO bioavailability.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Data-Review
[do] DOI:10.1021/acs.jproteome.7b00657

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[PMID]: 29305941
[Au] Autor:Hodge I; Adam A; Chennapragada M; Tiu A; Deshpande AV
[Ad] Address:Faculty of Health and Medicine, University of Newcastle, New South Wales, Australia. Electronic address: isabelle.hodge@gmail.com.
[Ti] Title:Traumatic Urethraggia in Adolescence: Ushering in the New Age of "Extreme Sports".
[So] Source:Urology;, 2018 Jan 03.
[Is] ISSN:1527-9995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Herein, we describe a case of a 14-year-old boy with straddle injury to the base of the penis, sustained during an indoor rock climbing accident, who presented with severe urethraggia. Urethral injury was confirmed with retrograde urethrography. The patient became hemodynamically unstable from persistent blood loss, and corporal arterial injury was diagnosed on computed tomography angiography. The urethraggia was successfully controlled with angioembolization. The unique aspects of this case were the challenges in establishing the diagnosis on the background of the abnormal presentation of vascular injury of blood loss as opposed to painless priapism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:Publisher

  5 / 2584 MEDLINE  
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[PMID]: 29278308
[Au] Autor:Gao L; Wu C; Fu F; You X; Ma X; Qin F; Li T; Wang R; Yuan J
[Ad] Address:The Andrology Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
[Ti] Title:Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism.
[So] Source:J Cell Mol Med;22(3):2018-2022, 2018 Mar.
[Is] ISSN:1582-4934
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Penile fibrosis caused by ischemic priapism (IP) adversely affects patients' erectile function. We explored the role of lysyl oxidase (LOX) in rat and human penes after ischemic priapism (IP) to verify the effects of anti-LOX in relieving penile fibrosis and preventing erectile dysfunction caused by IP in rats. Seventy-two rats were randomly divided into six groups: control group, control + ß-aminopropionitrile (BAPN) group, 9 hrs group, 9 hrs + BAPN group, 24 hrs group, and 24 hrs + BAPN group. ß-aminopropionitrile (BAPN), a specific inhibitor of LOX, was administered in the drinking water. At 1 week and 4 weeks, half of the rats in each group were randomly selected for the experiment. Compared to the control group, the erectile function of IP rats was significantly decreased while the expression of LOX in the corpus cavernosum was significantly up-regulated in both 9 and 24 hrs group. Proliferated fibroblasts, decreased corpus cavernosum smooth muscle cells/collagen ratios, destroyed endothelial continuity, deposited abnormal collagen and disorganized fibers were observed in IP rats. The relative content of collage I and III was not obviously different among the groups. ß-aminopropionitrile (BAPN) could effectively improve the structure and erectile function of the penis, and enhance recovery. The data in this study suggests that LOX may play an important role in the fibrosis of corpus cavernosum after IP and anti-LOX may be a novel target for patients suffering with IP.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:In-Data-Review
[do] DOI:10.1111/jcmm.13411

  6 / 2584 MEDLINE  
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[PMID]: 29479984
[Au] Autor:Barut O; Karakeçi A; Ozan T; Firdolas F; Pirinçci N; Orhan I
[Ti] Title:The role of apoptosis and the effect of epidermal growth factor on proapoptotic BNIP 3 in an experimental rat priapism model
[So] Source:Turk J Med Sci;48(1):191-195, 2018 Feb 23.
[Is] ISSN:1300-0144
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:Background/aim: This study aimed to investigate the effects of apoptosis-inducing Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP 3) and antiapoptotic epidermal growth factor (EGF) on the pathophysiology of experimental low-flow priapism. Materials and methods: Twenty-four adult Sprague-Dawley rats were divided into four equal groups. Group I was the control group. Ischemic priapism was induced for 4 h in Group II rats. In Group III, intraperitoneal EGF at 10 µg/kg was given for 7 days before induction of ischemic priapism for 4 h. In Group IV, intraperitoneal EGF at 20 µg/kg was given for 7 days before induction of ischemic priapism for 4 h. The western blot method was used to determine BNIP 3 expression levels and the TUNEL method was used to determine the apoptotic cells in the cavernosal tissue samples. Results: Although BNIP 3 expression levels were significantly higher in all three study groups compared to the controls, BNIP 3 was significantly higher in EGF-administered groups when compared to Group II (P < 0.05). The TUNEL score of group II was significantly higher than those of the other groups. Conclusion: Decreased apoptosis in cavernosal tissues obtained by antagonizing the apoptotic effect of BNIP 3 with EGF may facilitate the development of new conservative treatment methods via those pathways.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Data-Review
[do] DOI:10.3906/sag-1703-59

  7 / 2584 MEDLINE  
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[PMID]: 29463473
[Au] Autor:Johnson M; Murphy E; Raheem A; Ralph D
[Ad] Address:Andrology Department, University College London Hospital, London, UK. Electronic address: markjohnson@doctors.org.uk.
[Ti] Title:Poorly Controlled Homocystinuria: A Rare Cause of Ischemic Priapism?
[So] Source:Sex Med;, 2018 Feb 17.
[Is] ISSN:2050-1161
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We report on the 1st case of ischemic priapism secondary to poorly controlled homocystinuria. Homocystinuria is a rare, autosomal recessive, inherited disorder of metabolism that is caused by a deficiency of cystathionine synthase, leading to marked hyperhomocysteinemia. Arterial and/or venous thromboemboli are a major cause of mortality and morbidity in patients with homocystinuria. Untreated patients have a 50% chance of having a vascular event by 30 years of age. Increased homocysteine levels have been reported to upregulate prothrombotic factors and downregulate antithrombotic factors; in particular, increased homocystinuria has been found to downregulate nitric oxide (NO). Mice that are deficient in NO synthase in the cavernosal smooth muscles have a higher incidence of priapism. Decrease in NO synthase causes downregulation of cyclic guanosine monophosphate, phosphodiesterase type 5A, and Rho A/Rho-kinase. Because persistently increased homocysteine also downregulates NO, a similar mechanism could be proposed for priapism secondary to homocystinuria. In patients presenting with priapism, specific features of homocystinuria should be sought; in selected patients, screening with plasma total homocysteine might be appropriate. Ischemic priapism secondary to homocystinuria appears to respond well to the standard treatment options of aspiration, intracavernosal injection with phenylephrine, and, if required, a shunting procedure. Johnson M, Murphy E, Raheem A, Ralph D. Poorly Controlled Homocystinuria: A Rare Cause of Ischemic Priapism? Sex Med 2018;X:XXX-XXX.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:Publisher

  8 / 2584 MEDLINE  
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[PMID]: 29454716
[Au] Autor:Bullock N; Steggall M; Brown G
[Ad] Address:Department of Urology, Cwm Taf University Health Board, Royal Glamorgan Hospital, Llantrisant, UK. Electronic address: Nicholas.Bullock2@wales.nhs.uk.
[Ti] Title:Emergency Management of Priapism in the United Kingdom: A Survey of Current Practice.
[So] Source:J Sex Med;, 2018 Feb 14.
[Is] ISSN:1743-6109
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Despite its importance, current practice in the emergency management of priapism in the United Kingdom is unknown. AIM: To evaluate current practice in the emergency management of priapism in the United Kingdom. METHODS: All "full," "associate urological specialist," and "trainee" members of the British Association of Urological Surgeons (BAUS; leading membership-based organization for practitioners of urologic surgery in the United Kingdom) were invited to participate in an online survey. Questions related to the emergency management of priapism, access to tertiary andrology services, and use of guidelines. OUTCOMES: Key outcome measures included frequency of encountered cases, access to specialist andrology support, confidence in key management steps, and use of current guidelines. RESULTS: 213 of 1,304 (16.3%) eligible members completed the survey. Most reported managing 1 case annually (median = 1, range = 0->10). Only 7.0% transferred patients to a tertiary center and 87.8% believed they could access specialist andrology advice if required. Respondents were less confident in performing intracavernosal phenylephrine instillation (88.7%) compared with corporal aspiration (98.1%), with confidence lowest among trainee members. Only 68.5% reported performing the distal shunt procedure. Of the 212 respondents that chose to answer questions relating to guidelines, only 155 (73.1%) were aware of their existence, with those published by the European Association of Urology being most popular (53.8%). 205 (96.2%) respondents expressed an interest in the development of a UK-specific guideline, with 162 of 212 (76.4%) stating they would use this in practice. CLINICAL IMPLICATIONS: Urologists in the United Kingdom support the development of UK-specific guidance on the emergency management of priapism for use within the context of the National Health Service. STRENGTHS AND LIMITATIONS: This is the first study to assess current practice in the emergency management of priapism in the United Kingdom. Its strength is that most UK urologists were invited to participate through collaboration with the BAUS. Although the response rate of 16.3% is acceptable for a national survey of this nature, responses were self-reported, rendering them susceptible to bias. CONCLUSION: This study demonstrates that some UK urologists lack confidence in key steps in the emergency management of priapism and identifies a strong level of support for the development of up-to-date UK-specific guidance. Bullock N, Steggall M, Brown G. Emergency Management of Priapism in the United Kingdom: A Survey of Current Practice. J Sex Med 2018;XX:XXX-XXX.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:Publisher

  9 / 2584 MEDLINE  
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[PMID]: 29406065
[Au] Autor:Manjunath AS; Hofer MD
[Ad] Address:Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue 16-703, Chicago, IL 60611, USA.
[Ti] Title:Urologic Emergencies.
[So] Source:Med Clin North Am;102(2):373-385, 2018 Mar.
[Is] ISSN:1557-9859
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Urologic emergencies can involve the kidneys, ureters, bladder, urethra, penis, scrotum, or testicles. History and physical examination are essential to diagnosis, whereas imaging is increasingly used to confirm diagnoses. Acute urinary retention should be relieved with Foley placement. Penile emergencies include paraphimosis, which can be treated by foreskin reduction, whereas penile fracture and priapism require urologic intervention. Fournier gangrene and testicular torsion are scrotal emergencies requiring emergent surgery. Nephrolithiasis, although painful, is not an emergency unless there is concern for concomitant urinary tract infection, both ureters are obstructed by stones, or there is an obstructing stone in a solitary kidney.
[Mh] MeSH terms primary: Urologic Diseases/diagnosis
Urologic Diseases/therapy
[Mh] MeSH terms secundary: Acute Disease
Emergencies
Female
Female Urogenital Diseases/diagnosis
Female Urogenital Diseases/therapy
Fournier Gangrene/diagnosis
Fournier Gangrene/therapy
Humans
Male
Male Urogenital Diseases/diagnosis
Male Urogenital Diseases/therapy
Nephrolithiasis/diagnosis
Nephrolithiasis/microbiology
Nephrolithiasis/therapy
Paraphimosis/diagnosis
Paraphimosis/therapy
Penis/injuries
Priapism/diagnosis
Priapism/therapy
Referral and Consultation
Rupture
Spermatic Cord Torsion/diagnosis
Spermatic Cord Torsion/therapy
Urinary Retention/diagnosis
Urinary Retention/therapy
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180207
[St] Status:MEDLINE

  10 / 2584 MEDLINE  
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[PMID]: 29417263
[Au] Autor:Pei R; Yang M; Wang C; Wang J; Tong X; Zou Y
[Ad] Address:Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing, 100034, People's Republic of China.
[Ti] Title:Superselective Transcatheter Artery Embolization in Patients with Non-ischemic Priapism.
[So] Source:Cardiovasc Intervent Radiol;, 2018 Feb 07.
[Is] ISSN:1432-086X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To investigate the efficacy and safety of superselective transcatheter artery embolization in patients with non-ischemic priapism. MATERIALS AND METHODS: We retrospectively reviewed a cohort of 17 consecutive patients with non-ischemic priapism from September 2006 to August 2017. The median follow-up time was 8 months. RESULTS: Sixteen patients underwent superselective transcatheter artery embolization, and all had complete resolution of non-ischemic priapism. Fifteen of 16 patients (93.7%) underwent a single embolization without recurrence. A secondary embolization was required in one patient (6.3%) as a result of recurrence. Two of 16 patients (12.5%) had a decrease in their erectile function; one of the two patients had premorbid erectile dysfunction. Excluding the patient with premorbid erectile dysfunction, 14 of 15 patients (93.3%) maintained premorbid normal erectile function after embolization; the incidence of decrease in quality of erection is 6.7% (1/15). One patient did not undergo artery embolization because of negative findings of cavernous fistula by angiography. No angiography-related complications were found. CONCLUSION: Superselective transcatheter artery embolization is an effective and safe procedure for non-ischemic priapism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher
[do] DOI:10.1007/s00270-018-1895-2


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