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[PMID]: 29524717
[Au] Autor:Wang T; Gao T; Niu X; Xing X; Yang Y; Liu Y; Mao Q
[Ad] Address:Department of Neurosurgery, West China Hospital, Sichuan University, Guoxue Alley 37, Chengdu, 610041, China; Department of Neurosurgery, Xi'an Central Hospital, Xi'an, China.
[Ti] Title:Clinical Characteristics and Prognostic Analysis of Glioma with HIV Patients.
[So] Source:World Neurosurg;, 2018 Mar 07.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of this study was to perform an survival analysis of HIV patients with glioma and to assess the relationship between various prognostic factors and overall survival. METHODS: We reported in detail the management and prognosis of two patients in our hospital and performed a quantitative and comprehensive systematic literature review of patients with HIV-associated glioma. We combined our treatment experience with retrospectively obtained treatment information and studied the resultant survival time to statistically analyze and discuss whether age, surgery, gender, WHO grade, radiotherapy, chemotherapy and RT combined CTh could predict patients' survival. RESULT: We included 34 cases in our study, including two of our cases. The median survival was 9 months. On survival analysis, among the aforementioned parameters, WHO grade(LGG/HGG), surgery(SR/SB) and radiotherapy showed significant association with overall survival by univariate analysis. Multivariable analysis showed WHO grade and surgery were a significant predictor of OS. CONCLUSION: Most patients had astrocytoma or high-grade glioma. The median survival of all of glioma in HIV patients was shorter than that of GBM patients. Surgery and WHO grade were independent prognostic factors for overall survival.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 619864 MEDLINE  
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[PMID]: 29524704
[Au] Autor:Ji-Hu Y; Guo-Dong H; Tao J; Hai-Dong W; Yu-Fei L; Jian G; Zhen L; Wei-Ping L
[Ad] Address:Department of Neurosurgy,the First Affiliated Hospital Shenzhen University,Shenzhen 518035,China.
[Ti] Title:Endoscopic endonasal surgery treatment strategies for invasive pituitary adenoma: analysis of four approaches.
[So] Source:World Neurosurg;, 2018 Mar 07.
[Is] ISSN:1878-8769
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To explore the surgical methods and clinical effect of endoscopic endonasal approaches for the treatment of invasive pituitary adenomas(IPA). METHODS: A retrospective analysis of the clinical data of 74 patients(75 procedures) with invasive pituitary adenomas treated by different endoscopic endonasal approaches at the Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University from May 2014 to August 2017. The data include clinical manifestation, imaging features, surgical methods and complications, resection rate, cure rate, prognosis and complications in different Knosp classifications and Hardy stages. Among them, the trans-cavernous approach was used in 47 patients, the lateral-cavernous approach was used in 14 patients, the tuberculum sella planum approach was used in 8 patients, and the diaphragma sellae open and (or) dorsum sellae cut approach was used in 6 patients. RESULTS: The gross total resection (GTR) rate was 70.7% (53 patients ) and tumor residue rate was 29.3%(22 patients). GTR rate for pituitary adenoma according to Knosp classification was 89.3% in grade 3 and 28.6% in grade 4. The biology cure rate was 75.0% and 23.8%, respectively. There was significance between them (P<0.05). In addition, GTR rate of Hardy stage was 90.5% in stage C, 90.0% in stage D, 26.1% in stage E, and biology cure rate was 80.1%, 75.0% and 13.0%, respectively. There was significance among them (P<0.05) Postoperative severe complications included 9 patients (12.0%) with cerebrospinal fluid leaks, 26 patients(34.7%)with electrolyte imbalance, 36 patients (48.0%) with transient diabetes insipidus , 22 patients (29.3%) with hypopituitarism, 2 patients (2.7%) with permanent hypopituitarism, and 2 patient(2.7%)epistaxis. The follow-up lasted 2-41 months, average 19.3 months. None of them recurred after the GTR, one subtotal resection patient recurred and received reoperation, three patients accepted postoperative treatment of Gamma knife, and two patients with refractory IPA were given temozolomide and metformin chemotherapy. CONCLUSIONS: According to the invasiveness of IPA, choosing proper endoscopic surgical approach is helpful to remove tumors and to reduce the complications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 619864 MEDLINE  
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[PMID]: 29524648
[Au] Autor:Chen JT; Liu CC; Yu JS; Li HH; Lai MC
[Ad] Address:Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan; Department of Surgery, Department of Medical Research and Development, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan.
[Ti] Title:Integrated omics profiling identifies hypoxia-regulated genes in HCT116 colon cancer cells.
[So] Source:J Proteomics;, 2018 Mar 07.
[Is] ISSN:1876-7737
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Hypoxia is associated with poor prognosis in most solid tumors due to its multiple effects on therapy resistance, angiogenesis, apoptotic resistance, and tumor invasion/metastasis. Here we used a comprehensive omics profiling to investigate hypoxia-regulated gene expression in HCT116 colon cancer cells. Quantitative analyses of proteome and secretome were performed in HCT116 cells cultured under hypoxic or normoxic conditions. A total of 5700 proteins were quantified in proteome analysis and 722 proteins were quantified in secretome analysis. Both datasets were combined with the transcriptome and translatome datasets for further analysis. Verification of candidate proteins/genes in this integrated omics analysis was performed using immunoblotting and quantitative real-time RT-PCR analyses. We also performed polysome profiling to assess changes in translational efficiency of hypoxia-induced genes. Notably, several genes were differently regulated at the transcriptional and translational levels in HCT116 cells during hypoxia. Bioinformatics analysis suggested that hypoxia regulates translation of genes involved in extracellular matrix organization, extracellular exosomes, and protein processing in endoplasmic reticulum. Aberrations in these metabolic pathways appear to be correlated with an increased risk of tumor invasion/metastasis. BIOLOGICAL SIGNIFICANCE: This study integrates transcriptome/translatome and proteome/secretome to analyze gene expression changes in human colon cancer cells under hypoxic conditions. Candidate proteins/genes in this integrated omics analysis were further validated by immunoblotting, quantitative real-time RT-PCR, and polysome profiling. The datasets would be useful to uncover the molecular mechanisms of hypoxia-induced gene regulation in colorectal cancer.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 619864 MEDLINE  
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[PMID]: 29524637
[Au] Autor:Zhang S; An Q; Wang T; Gao S; Zhou G
[Ad] Address:Department of Medical Genetics and Cell Biology, Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine, Health Sciences Center, Shenzhen University, Shenzhen, 518060, China.
[Ti] Title:Autophagy- and MMP-2/9-mediated Reduction and Redistribution of ZO-1 Contribute to Hyperglycemia-increased Blood-Brain Barrier Permeability during Early Reperfusion in Stroke.
[So] Source:Neuroscience;, 2018 Mar 07.
[Is] ISSN:1873-7544
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Post-stroke hyperglycemia during early reperfusion increases blood-brain barrier (BBB) permeability and subsequently aggravates brain injury and clinical prognosis. The decreased level of tight junction proteins (TJPs) has been reported but the underlying mechanism remains largely elusive. Herein we designed to investigate the detailed molecular events in brain microvascular endothelial cells (BMECs) ex and in vivo. After oxygen-glucose deprivation (OGD) for 90 min and reperfusion with 8 or 16 mM glucose for 30 min, glucose at 16 mM caused significant decrease of the TJP expression and particularly ZO-1 redistribution from membrane to cytoplasm of BMECs. High glucose also markedly promoted the secretion of MMP-2/9 and oxidative/nitrosative stress, enhanced autophagy and increased the Caveolin-1 and LAMP-2 expression. Moreover, in vivo experiments demonstrated that rapamycin-enhanced autophagy further caused ZO-1 reduction and the increased BBB permeability. Therefore, high glucose exposure in the early reperfusion causes the BBB disruption, with MMP-2/9-mediated extracellular degradation, caveolin-1-mediated intracellular translocation and autophagy-lysosome-mediated degradation of ZO-1 protein all together involved in the process. The role of MMP-2/-9 and autophagy in the modulation of paracellular permeability was confirmed by pharmacological inhibition. Therefore, our findings may provide new insights into targeting ZO-1 regulation for the purpose of significantly improving the clinical prognosis of ischemic stroke.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  5 / 619864 MEDLINE  
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[PMID]: 29524533
[Au] Autor:Forrest EH; Atkinson SR; Richardson P; Masson S; Ryder S; Thursz MR; Allison M; STOPAH Trial Management Group
[Ad] Address:Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, United Kingdom. Electronic address: Ewan.Forrest@ggc.scot.nhs.uk.
[Ti] Title:The long-term prognosis of Alcoholic Hepatitis is poor and independent of disease severity for patients surviving an acute episode (Reply).
[So] Source:J Hepatol;, 2018 Mar 07.
[Is] ISSN:1600-0641
[Cp] Country of publication:Netherlands
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  6 / 619864 MEDLINE  
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[PMID]: 29524529
[Au] Autor:Sandahl TD; Vilstrup H; Jepsen P
[Ad] Address:Department of Hepatology and Gastroenterology, Aarhus University Hospital, Denmark. Electronic address: Thomas.Damgaard.Sandahl@ki.au.dk.
[Ti] Title:The long-term prognosis of Alcoholic Hepatitis is poor and independent of disease severity for patients surviving an acute episode.
[So] Source:J Hepatol;, 2018 Mar 07.
[Is] ISSN:1600-0641
[Cp] Country of publication:Netherlands
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  7 / 619864 MEDLINE  
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[PMID]: 29524528
[Au] Autor:Serst T; Cornillie A; Njimi H; Pavesi M; Arroyo V; Putignano A; Weichselbaum L; Deltenre P; Degr D; Trpo E; Moreno C; Gustot T
[Ad] Address:Liver Unit, Department of Gastroenterology and Hepatopancreatology and Digestive Oncology, CUB Hpital Erasme, Universit Libre de Bruxelles, Bruxelles, Belgium; Department of Hepatogastroenterology, CHU Saint-Pierre, Bruxelles, Belgium. Electronic address: thomas.serste@skynet.be.
[Ti] Title:The prognostic value of Acute-on-Chronic Liver Failure during the course of severe alcoholic hepatitis.
[So] Source:J Hepatol;, 2018 Mar 07.
[Is] ISSN:1600-0641
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND & AIMS: A better identification of factors predicting death is needed in alcoholic hepatitis. Acute-on-chronic liver failure (ACLF) occurs during the course of liver disease and can be identified when AH is diagnosed (prevalent ACLF, pACLF) or during follow-up (incidental ACLF, iACLF). This study analyzed the impact of ACLF on outcomes in AH and the role of infection in the onset of ACLF and death. METHODS: Patients admitted from July, 2006 to July, 2015 suffering from biopsy-proven severe (s)AH with a Maddrey discriminant function (mDF) ≥32 were included. Infectious episodes, ACLF, and mortality were assessed during a 168-day follow-up period. Results were validated on an independent cohort. RESULTS: One hundred sixty-five patients were included. Mean mDF was 66.320.7 and mean MELD score was 26.87.4. The 28-day cumulative incidence of death (CID) was 31% (95%CI, 24-39%). Seventy-nine patients (47.9%) had pACLF. The 28-day CID without pACLF and with pACLF-1, pACLF-2, and pACLF-3 were 10.4% (95%CI, 5.1-18.0), 30.8% (95%CI, 14.3-49.0), 58.3% (95%CI, 35.6-75.5), and 72.4% (95%CI, 51.3-85.5), respectively, p <0.0001. Twenty-nine patients (17.5%) developed iACLF. The 28-day relative risk of death in patients developing iACLF was 41.87 (95%CI, 5.2-335.1, p< 0.001). A previous infection was the only independent risk factor for developing iACLF during the follow-up. Prevalence, incidence, and impact on prognosis of ACLF were confirmed in a validation cohort of 97 patients with probable sAH. CONCLUSIONS: ACLF is frequent during the course of sAH and is associated with high mortality. Infection strongly predicts the development of ACLF in this setting. LAY SUMMARY: In patients with chronic liver disease, an acute deterioration of liver function combined with single or multiple organ failures is known as acute-on-chronic liver failure (ACLF). This study shows that ACLF is frequent during the course of severe alcoholic hepatitis (sAH). In sAH, ACLF is associated with high mortality and frequently occurs secondary to a previous infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  8 / 619864 MEDLINE  
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[PMID]: 29524519
[Au] Autor:Fasolato S; Trevellin E; Ruvoletto M; Granzotto M; Zanus G; Boscaro E; Babetto E; Terrin L; Battocchio MA; Ciscato F; Turato C; Quarta S; Cillo U; Pontisso P; Vettor R
[Ad] Address:Dept of Medicine, University of Padua, Italy.
[Ti] Title:SerpinB3 induces dipeptidyl-peptidase IV/CD26 expression and its metabolic effects in hepatocellular carcinoma.
[So] Source:Life Sci;, 2018 Mar 07.
[Is] ISSN:1879-0631
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:AIMS: In hepatocellular carcinoma (HCC), the regulatory protease Dipeptidyl-peptidase IV (DPPIV/CD26), that possesses pro-apoptotic properties, has been found abnormally regulated. The protease inhibitor SerpinB3, exerting anti-apoptotic activity, has also been described to be upregulated, especially in HCCs with poor prognosis. The aim of this study was to investigate the possible relationship between these two molecules in HCC patients and in experimental models. MATERIALS AND METHODS: DPPIV/CD26 and SerpinB3 expression was measured in liver specimens of 67 patients with HCC. HepG2 and Huh7 cells, stably transfected to overexpress SerpinB3, and respective control cells were used to assess biological and metabolic modifications of DPPIV/CD26 activity induced by this serpin. KEY FINDINGS: DPPIV/CD26 and SerpinB3 were localized in the same tumoral areas and both molecules was directly correlated with the grade of tumor differentiation, with the highest values detected in GI tumors. Cell lines over-expressing SerpinB3 displayed upregulation of DPPIV/CD26, likely as a feedback mechanism, due to the DPPIV/CD26 protease activity inhibition by SerpinB3, as confirmed by the similar behavior induced by the inhibitor Sitagliptin. Moreover, they exhibited lower glycogen storage and higher lipid accumulation, typical effects of DPPIV/CD26. SIGNIFICANCE: A close connection between SerpinB3 and DPPPIV has been identified, but further studies are required to better understand the mechanism by which these proteins communicate and exert metabolic effects in HCC.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  9 / 619864 MEDLINE  
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[PMID]: 29520384
[Au] Autor:May M; Fritsche HM; Gilfrich C; Dombrowski M; Maurer O; Spachmann P; Kumar MG; Bjurlin M; Burger M; Brookman-May S
[Ad] Address:Department of Urology, St. Elisabeth Hospital Straubing, Straubing, Germany.
[Ti] Title:What do patients with urothelial cancer know about the association of their tumor disease with smoking habits? Results of a German survey study.
[So] Source:Investig Clin Urol;59(2):91-97, 2018 Mar.
[Is] ISSN:2466-054X
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Purpose: Smoking represents a primary risk factor for the development of urothelial carcinoma (UC) and a relevant factor impacting UC-specific prognosis. Data on the accordant knowledge of UC-patients in this regard and the significance of physicians in the education of UC-patients is limited. Materials and Methods: Eighty-eight UC-patients were enrolled in a 23-items-survey-study aimed to analyse patient knowledge and awareness of their tumor disease with smoking along with physician smoking cessation counselling. Results: The median age of the study patients was 69 years; 26.1% (n=23), 46.6% (n=41), and 27.3% (n=24), respectively, were non-smokers, previous, and active smokers. Exactly 50% of active smokers reported a previous communication with a physician about the association of smoking and their tumor disease; however, only 25.0% were aware of smoking as main risk factor for UC development. Merely 33% of the active smokers had been prompted directly by their physicians to quit smoking. About 42% of active smokers had received the information that maintaining smoking could result in a tumor-specific impairment of their prognosis. Closely 29% of active and about 5% of previous smokers (during the time-period of active smoking) had been offered support from physicians for smoking cessation. No association was found between smoking anamnesis (p=0.574) and pack-years (p=0.912), respectively, and tumor stage of UC. Conclusions: The results of this study suggest that the medical conversation of physicians with UC-patients about the adverse significance of smoking is limited. Implementation of structured educational programs for smoking cessation may be an opportunity to further enhance comprehensive cancer care.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.4111/icu.2018.59.2.91

  10 / 619864 MEDLINE  
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[PMID]: 29520176
[Au] Autor:Park SY; Cho NH; Jung DC; Oh YT
[Ad] Address:Department of Radiology, Yonsei University College of Medicine, Seoul 03722, Korea.
[Ti] Title:Prostate Imaging-Reporting and Data System Version 2: Beyond Prostate Cancer Detection.
[So] Source:Korean J Radiol;19(2):193-200, 2018 Mar-Apr.
[Is] ISSN:2005-8330
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:The main purpose of Prostate Imaging-Reporting and Data System Version 2 (PI-RADSv2) is to effectively detect clinically significant prostate cancers (csPCa) using multiparametric magnetic resonance imaging. Since the first introduction of PI-RADSv2, researchers have validated its diagnostic performance in identifying csPCa, and these promising data have influenced biopsy and treatment schemes. However, in this article, we focused on the potential of PI-RADSv2 in relation to various aspects of PCa such as Gleason score, tumor volume, extraprostatic extension, lymph node metastasis, and postoperative biochemical recurrence, beyond prostate cancer detection.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.3348/kjr.2018.19.2.193


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