Database : MEDLINE
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[PMID]: 29408984
[Au] Autor:Koskenniemi JJ; Virtanen HE; Wohlfahrt-Veje C; Löyttyniemi E; Skakkebaek NE; Juul A; Andersson AM; Main KM; Toppari J
[Ad] Address:Departments of Physiology, Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
[Ti] Title:Postnatal Changes in Testicular Position are Associated with IGF-I and Function of Sertoli and Leydig Cells.
[So] Source:J Clin Endocrinol Metab;, 2018 Feb 01.
[Is] ISSN:1945-7197
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Context: Despite clinical guidelines calling for repetitive examination of testicular position during childhood, little is known of normal changes in testicular position during childhood, let alone factors that control it. Objective: To assess changes in, and factors associated with testicular position during childhood. Design: Testicular position (the distance from the pubic bone to the upper pole of the testes) at birth, 3 months, 18 months, 36 months, 7 years and reproductive hormones at three months were measured. Setting: Prenatally recruited, prospective longitudinal birth cohort. Participants: In total 2545 boys were recruited prenatally in a Danish-Finnish birth cohort and had testicular position examination available. A subset of 680 Danish and 362 Finnish boys had serum reproductive hormone concentrations and insulin-like growth factor I (IGF-I) determined at three months. Main Outcome Measures: Testicular distance to pubic bone (TDP), serum reproductive hormone and IGF-I concentrations. Results: TDP increased from birth to three months, and decreased thereafter. Length, gestational age, weight for gestational age, and penile length were positively associated with larger TDP and thus lower testicular position in a linear mixed-effect model. Furthermore, IGF-I concentration, inhibin B/FSH-ratio, and testosterone/LH-ratio were all independently and positively associated with longer TDP. Conclusions: We provide the first longitudinal data on postnatal changes in TDP. TDP is dynamic and associated with Leydig and Sertoli cell function as well as with IGF-I levels during the first months of life at minipuberty of infancy. TDP may thus be a useful biomarker of postnatal testicular function.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1210/jc.2017-01889

  2 / 3185 MEDLINE  
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[PMID]: 29231664
[Au] Autor:Hem E; Brodal P
[Ti] Title:Skamben bør kastes ut av ordbøkene.
[So] Source:Tidsskr Nor Laegeforen;137(23-24), 2017 12 12.
[Is] ISSN:0807-7096
[Cp] Country of publication:Norway
[La] Language:nor
[Mh] MeSH terms primary: Pubic Bone
Terminology as Topic
[Mh] MeSH terms secundary: Humans
Norway
[Pt] Publication type:LETTER
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[Js] Journal subset:IM
[Da] Date of entry for processing:171213
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.17.0914

  3 / 3185 MEDLINE  
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[PMID]: 29198716
[Au] Autor:Petryla G; Uvarovas V; Satkauskas I; Masionis P; Porvaneckas N
[Ad] Address:Department of Orthopedics and Traumatology, Vilnius University Faculty of Medicine, Republican Vilnius University Hospital, Siltnamiu Str. 29, 04130, Vilnius, Lithuania.
[Ti] Title:Non-anatomic fixation for longstanding traumatic pubic diastasis using a bone graft: A report of two cases.
[So] Source:Chin J Traumatol;20(6):362-365, 2017 Dec.
[Is] ISSN:1008-1275
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:The incidence of internal fixation failure of symphysis diastasis varies from 6% to 75%. Hardware breakage or migration and symphysis disruption recurrence are often asymptomatic and only in a few cases reoperation is required. This report describes the managements of two cases after failed internal fixation and neglected traumatic symphysis diastasis when it was technically impossible to achieve anatomical reduction of the anterior pelvic ring. Internal fixation and a bone graft for the symphysis without anatomical reposition were performed. Both of the patients achieved good results and had no complaints of pain during daily activities. Restoration of the anatomy should not be the aim in treating recurrence of the symphysis diastasis after failed fixation. The aim of the surgery was static fixation of the anterior pelvic ring with bone grafting.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process

  4 / 3185 MEDLINE  
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[PMID]: 29481980
[Au] Autor:Shih YC; Beaubien BP; Chen Q; Sembrano JN
[Ad] Address:University of Minnesota, Department of Orthopaedic Surgery, Minneapolis, MN 55414.
[Ti] Title:Biomechanical evaluation of sacroiliac joint fixation with decortication.
[So] Source:Spine J;, 2018 Feb 23.
[Is] ISSN:1878-1632
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND CONTEXT: Fusion typically consists of joint preparation, grafting and rigid fixation. Fusion has been successfully used to treat symptomatic disruptions of the SIJ and degenerative sacroiliitis using purpose-specific, threaded implants. The biomechanical performance of these systems is important but has not been studied. PURPOSE: To compare two techniques for placing primary (12.5mm) and secondary (8.5mm) implants across the SIJ. STUDY DESIGN: A human cadaveric biomechanical study of sacroiliac joint (SIJ) fixation. METHODS: Pure moment testing was performed on fourteen human sacroiliac joints in flexion-extension (FE), lateral bending (LB) and axial rotation (AR) with motion measured across the SIJ. Specimens were tested Intact; after Destabilization (cutting the pubic symphysis); after decortication and Implantation of a primary 12.5mm implant at S1 plus an 8.5mm secondary implant at either S1 (S1/S1, n=8) or S2 (S1/S2, n=8); after Cyclic Loading; after removal of the secondary implant. Ranges of motion (ROM) were calculated for each test. Bone density was assessed on CT and correlated with age and ROM. This study was funded by Zyga Technology but was run at an independent biomechanics laboratory. RESULTS: The mean ± SD intact ROM was 3.0±1.6 degrees in FE, 1.5±1.0 degrees in LB and 2.0±1.0 in AR. Destabilization significantly increased the ROM by a mean 60-150%. Implantation in-turn significantly decreased ROM by 65-71%, below the intact ROM. Cyclic loading did not impact ROM. Removing the secondary implant increased ROM by 46-88% (nonsignificant). There was no difference between S1/S1 and S1/S2 constructs. Bone density was inversely correlated to age (R=.69) and ROM (R=.36-.58). CONCLUSIONS: Fixation with two threaded rods significantly reduces SIJ motion even in the presence of joint preparation and after initial loading. The location of the secondary, 8.5mm implant does not affect construct performance. Low bone density significantly affects fixation and should be considered when planning fusion constructs. Findings should be interpreted in the context of ongoing clinical studies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher

  5 / 3185 MEDLINE  
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[PMID]: 29396018
[Au] Autor:van Ladesteijn R; Leslie H; Manning WA; Holland JP; Deehan DJ; Pandorf T; Aspden RM
[Ad] Address:Arthritis and Musculoskeletal Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. Electronic address: r.vanladesteijn.14@aberdeen.ac.uk.
[Ti] Title:Mechanical properties of cancellous bone from the acetabulum in relation to acetabular shell fixation and compared with the corresponding femoral head.
[So] Source:Med Eng Phys;53:75-81, 2018 Mar.
[Is] ISSN:1873-4030
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:To gain initial stability for cementless fixation the acetabular components of a total hip replacement are press-fit into the acetabulum. Uneven stiffness of the acetabular bone will result in irregular deformation of the shell which may hinder insertion of the liner or lead to premature loosening. To investigate this, we removed bone cores from the ilium, ischium and pubis within each acetabulum and from selected sites in corresponding femoral heads from four cadavers for mechanical testing in unconfined compression. From a stress-relaxation test over 300 s, the residual stress, its percentage of the initial stress and the stress half-life were calculated. Maximum modulus, yield stress and energy to yield (resilience) were calculated from a load-displacement test. Acetabular bone had a modulus about 10-20%, yield stress about 25% and resilience about 40% of the values for the femoral head. The stress half-life was typically between 2-4 s and the residual stress was about 60% of peak stress in both acetabulum and femur. Pubic bone was mechanically the poorest. These results may explain uneven deformation of press-fit acetabular shells as they are inserted. The measured half-life of stress-relaxation indicates that waiting a few minutes between insertion of the shell and the liner may allow seating of a poorly congruent liner.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180224
[Lr] Last revision date:180224
[St] Status:In-Data-Review

  6 / 3185 MEDLINE  
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[PMID]: 29462708
[Au] Autor:Holopainen E; Vakkilainen S; Mäkitie O
[Ad] Address:Women's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address: elina.holopainen@hus.fi.
[Ti] Title:Diversity of pubertal development in cartilage-hair hypoplasia - two illustrative cases.
[So] Source:J Pediatr Adolesc Gynecol;, 2018 Feb 17.
[Is] ISSN:1873-4332
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Cartilage-hair hypoplasia (CHH) is a rare chondrodysplasia, including disproportionate short stature, hypoplastic hair, immunodeficiency and increased risk of malignancies. Absent pubertal growth spurt and absent pubic hair complicate monitoring of pubertal development in these patients. CASES: Two CHH patients with delayed puberty and excessive growth failure are described. One of the girls had hypogonadotropic hypogonadism while the other had hypo-normogonadotropic hypogonadism with no spontaneous pubertal development and slow response to estrogen therapy, both requiring permanent replacement therapy. SUMMARY AND CONCLUSIONS: Careful follow up of pubertal development in individuals with CHH and other growth restricting bone diseases is needed. In delayed pubertal development timely hormone therapy is essential to ensure maximal growth and well-developed secondary sex characteristics.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher

  7 / 3185 MEDLINE  
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[PMID]: 28467628
[Au] Autor:Couoh LR
[Ad] Address:Postgraduate Division, Faculty of Philosophy and Literature, Institute of Anthropological Research, The National Autonomous University of Mexico [UNAM], Coyoacán, Mexico city, 04510, Mexico.
[Ti] Title:Differences between biological and chronological age-at-death in human skeletal remains: A change of perspective.
[So] Source:Am J Phys Anthropol;163(4):671-695, 2017 08.
[Is] ISSN:1096-8644
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: This analysis seeks to determine whether differences between real and estimated chronological age (CA) with biological age (BA) in skeletal individuals reflect variability in aging. MATERIAL AND METHODS: A total of 87 individuals of two samples, ranging from 20 to 94 years old, were analyzed. One, partially documented, belongs to a Mexican skeletal collection dating to the 20th century; the other is an assemblage of prehispanic individuals from different archaeological sites. In all specimens, the tooth annulation method (TCA) was applied to estimate CA, while-excluding individuals older than 80 years-auricular surface (AS) and pubic symphysis (PS) methods were used to estimate BA. Statistical analyses were conducted to identify correlations and significance of the differences between CA vs. TCA, CA vs. AS/PS, TCA vs. AS/PS. Sex of individuals was assessed for its influence in aging. RESULTS: The use of TCA to estimate CA was successful for most individuals. A strong correlation was found between CA vs. TCA, CA vs. AS/PS, TCA vs. AS/PS and their differences were significant but variation in these were found when assessed by separate age groups. Sex did not influence such differences. DISCUSSION: TCA can be used to estimate CA and its differences with BA, being less than 10 years, are similar to those found in living populations. Differences between CA and BA are due to intra-population variability, which could be the consequence of individual differences in aging. More research is needed to have confidence that under- and overestimations of BA are indicators of aging variability at the level of the individual.
[Mh] MeSH terms primary: Age Determination by Skeleton/methods
Age Determination by Teeth/methods
Aging/physiology
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Anthropology, Physical
Dental Cementum/physiology
Female
Humans
Indians, Central American
Male
Mexico
Middle Aged
Models, Statistical
Tooth Root/physiology
Young Adult
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1708
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[Js] Journal subset:IM
[Da] Date of entry for processing:170504
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.23236

  8 / 3185 MEDLINE  
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[PMID]: 29390586
[Au] Autor:Wu W; Wang C; Ruan J; Chen F; Li N; Chen F
[Ad] Address:Department of Orthopedics.
[Ti] Title:A case report of phosphaturic mesenchymal tumor-induced osteomalacia.
[So] Source:Medicine (Baltimore);96(51):e9470, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Tumor-induced osteomalacia (TIO) is a rare and often misdiagnosed syndrome. Surgical resection is currently the first line treatment for TIO. PATIENT CONCERNS: Here we report the case of a 49-year-old woman presented with intermittent pain in the right chest and bilateral hip that had persisted for over two years. DIAGNOSES: She was diagnosed of TIO caused by a phosphaturic mesenchymal tumor based on the following examinations. Laboratory tests revealed high serum alkaline phosphatase, high urinary phosphorus, hypophosphatemia and normal serum calcium levels. 18-FDG PET/CT indicated a systemic multi-site symmetrical pseudo fracture and a tumor in the 7th right rib. INTERVENTIONS: Curettage of the tumor was performed, and pathological analysis also confirmed our diagnoses as a phosphaturic mesenchymal tumor. OUTCOMES: At seven months post-surgery, the symptoms were relieved, proximal muscle strength was improved and serum levels of phosphorus and alkaline phosphatase normalized. The bilateral femoral neck and bilateral pubic bone fractures were blurred in the pelvic plain X-ray, suggesting that the fracture was healing. LESSONS: This case report strengthened the importance of recognition of this rare disease to avoid delay of diagnosis and surgical removal of the causative tumor is recommended.
[Mh] MeSH terms primary: Bone Neoplasms/complications
Hypophosphatemia, Familial/etiology
Neoplasms, Connective Tissue/etiology
Osteomalacia/etiology
[Mh] MeSH terms secundary: Alkaline Phosphatase/blood
Bone Neoplasms/diagnosis
Bone Neoplasms/diagnostic imaging
Female
Humans
Middle Aged
Positron-Emission Tomography
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009470

  9 / 3185 MEDLINE  
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[PMID]: 29276058
[Au] Autor:Kim SI; Lee S; Jeong CW; Kim HS
[Ad] Address:Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
[Ti] Title:Robot-assisted anterior pelvic exenteration in vulvovaginal malignant melanoma.
[So] Source:Gynecol Oncol;148(2):430-431, 2018 Feb.
[Is] ISSN:1095-6859
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Melanomas of the vulva and vagina are rare, and surgery is the gold standard of treatment [1, 2]. Since recent studies have reported pelvic exenteration by using robotic surgical system [3, 4], we showed the surgical procedures of robot-assisted anterior pelvic exenteration (rAPE) with ileal conduit urinary diversion for vulvovaginal malignant melanoma. METHODS: A 55-year-old woman who received vaginal wall resection due to vaginal malignant melanoma 8months before was referred. Multiple biopsies of pigmented lesions on the vulva, vagina, and urethral orifice confirmed the recurrence, whereas preoperative image studies revealed no abnormal findings. Thus, we performed rAPE with ileal conduit urinary diversion. RESULTS: First, we performed robot-assisted bilateral inguinal and pelvic lymphadenectomy. Thereafter, we conducted en bloc resection of the bladder, uterus, vagina, and vulva through abdominal and perineal approaches (Fig. 1): Under the 4-arm robotic surgical system, prevesical space was developed and laterally dissected along the undersurface of pubic bone, to the level of levator ani muscles. Bilateral infudibulopelvic ligaments, uterine arteries and parametrium, uterosacral ligaments, and pubovesical ligaments were ligated and resected. During the wide local excision of the vulva, the rectovaginal space was dissected along the posterior vaginal wall. En bloc specimen was successfully delivered. Finally, the ileal conduit urinary diversion was performed. Total operative time was 4.5h excluding set-up and docking times of the robotic surgical system. The pathologic report ascertained clear resection margin and no lymph node involvement. CONCLUSION: rAPE with ileal conduit urinary diversion for treatment of vulvovaginal malignant melanoma is feasible (Fig. 1).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180206
[Lr] Last revision date:180206
[St] Status:In-Data-Review

  10 / 3185 MEDLINE  
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[PMID]: 29262869
[Au] Autor:Okoshi K; Mizumoto M; Kinoshita K
[Ad] Address:Department of Surgery, The Japan Baptist Hospital, 47 Yamanomoto-cho, Kitashirakawa, Sakyo-ku, Kyoto, 606-8273, Japan. kae_md@kuhp.kyoto-u.ac.jp.
[Ti] Title:Endometriosis-associated hydrocele of the canal of Nuck with immunohistochemical confirmation: a case report.
[So] Source:J Med Case Rep;11(1):354, 2017 Dec 21.
[Is] ISSN:1752-1947
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The canal of Nuck is an embryological vestige of the processus vaginalis, and presents a potential site for endometriosis seeding. Hydroceles in this region are a rare cause of inguinal swelling in females. In addition, endometriosis localized to the canal of Nuck is exceedingly rare. CASE PRESENTATION: A 44-year-old Japanese woman presented with a painful mass overlying her right pubis. She underwent surgery to completely excise the mass. During surgery, division of the external oblique aponeurosis revealed a cyst that occupied the inguinal canal and it adhered to the transverse fascia, inguinal ligament, and pubic bone. The cyst was dissected from the round ligament, and the defect in the internal inguinal ring was repaired and reinforced with mesh. On macroscopic examination, the cyst had a heterogeneous fibrous aspect with dark brown inclusions. Microscopic examination revealed that the cyst was tortuous, lined by mesothelial-like cells, and accompanied by partial subcapsular hemorrhage. Endometrium-like tissue was observed in the cystic wall. Immunohistochemical staining for podoplanin confirmed the mesothelial origin of the cyst-lining cells. The epithelial cells and stromal cells were positive for estrogen receptors. CONCLUSIONS: In this case of an endometriosis-associated hydrocele of the canal of Nuck, the mesothelial origin of the cyst-lining cells and endometriosis were confirmed by positive immunohistochemical staining for podoplanin and estrogen receptors, respectively. We determined that hydrocele resection and reinforcement of the anterior inguinal canal wall (if necessary) are appropriate treatments for this condition.
[Mh] MeSH terms primary: Cysts/diagnostic imaging
Endometriosis/diagnostic imaging
Peritoneal Diseases/diagnostic imaging
[Mh] MeSH terms secundary: Adult
Cysts/metabolism
Cysts/pathology
Cysts/surgery
Endometriosis/metabolism
Endometriosis/pathology
Endometriosis/surgery
Female
Humans
Immunohistochemistry
Inguinal Canal
Peritoneal Diseases/metabolism
Peritoneal Diseases/pathology
Peritoneal Diseases/surgery
Receptors, Estrogen/metabolism
Tomography, X-Ray Computed
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Receptors, Estrogen)
[Em] Entry month:1801
[Cu] Class update date: 180130
[Lr] Last revision date:180130
[Js] Journal subset:IM
[Da] Date of entry for processing:171222
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1522-x


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