Database : MEDLINE
Search on : quality and of and life [Words]
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[PMID]: 29524896
[Au] Autor:Pathak D; Whitehead PG; Futter MN; Sinha R
[Ad] Address:Department of Earth Sciences, Indian Institute of Technology Kanpur, Kanpur 208016, India.
[Ti] Title:Water quality assessment and catchment-scale nutrient flux modeling in the Ramganga River Basin in north India: An application of INCA model.
[So] Source:Sci Total Environ;631-632:201-215, 2018 Mar 07.
[Is] ISSN:1879-1026
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The present study analyzes the water quality characteristics of the Ramganga (a major tributary of the Ganga river) using long-term (1991-2009) monthly data and applies the Integrated Catchment Model of Nitrogen (INCA-N) and Phosphorus (INCA-P) to the catchment. The models were calibrated and validated using discharge (1993-2011), phosphate (1993-2010) and nitrate (2007-2010) concentrations. The model results were assessed based on Pearson's correlation, Nash-Sutcliffe and Percentage bias statistics along with a visual inspection of the outputs. The seasonal variation study shows high nutrient concentrations in the pre-monsoon season compared to the other seasons. High nutrient concentrations in the low flows period pose a serious threat to aquatic life of the river although the concentrations are lowered during high flows because of the dilution effect. The hydrological model is satisfactorily calibrated with R and NS values ranging between 0.6-0.8 and 0.4-0.8, respectively. INCA-N and INCA-P successfully capture the seasonal trend of nutrient concentrations with R >0.5 and PBIAS within ±17% for the monthly averages. Although, high concentrations are detected in the low flows period, around 50% of the nutrient load is transported by the monsoonal high flows. The downstream catchments are characterized by high nutrient transport through high flows where additional nutrient supply from industries and agricultural practices also prevail. The seasonal nitrate (R : 0.88-0.94) and phosphate (R : 0.62-0.95) loads in the catchment are calculated using model results and ratio estimator load calculation technique. On average, around 548tonnes of phosphorus (as phosphate) and 77,051tonnes of nitrogen (as nitrate) are estimated to be exported annually from the Ramganga River to the Ganga. Overall, the model has been able to successfully reproduce the catchment dynamics in terms of seasonal variation and broad-scale spatial variability of nutrient fluxes in the Ramganga catchment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 319908 MEDLINE  
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[PMID]: 29524772
[Au] Autor:Lindqvist M; Persson M; Nilsson M; Uustal E; Lindberg I
[Ad] Address:Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Sweden. Electronic address: maria.lindqvist@umu.se.
[Ti] Title:'A worse nightmare than expected' - a Swedish qualitative study of women's experiences two months after obstetric anal sphincter muscle injury.
[So] Source:Midwifery;61:22-28, 2018 Feb 20.
[Is] ISSN:1532-3099
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:OBJECTIVE: this study explores women's experiences of the first two months after obstetric anal sphincter injury (OASIS) during childbirth with a focus on problematic recovery. METHODS: this qualitative study used inductive qualitative content analysis to investigate open-ended responses from 1248 women. The data consists of short and comprehensive written responses to open-ended questions focusing on recovery in the national quality register, the Perineal Laceration Register, two months after OASIS at childbirth. RESULTS: the theme 'A worse nightmare than expected' illustrated women's experiences of their life situation. Pain was a constant reminder of the trauma, and the women had to face physical and psychological limitations as well as crushed expectations of family life. Furthermore, navigating healthcare services for help added further stress to an already stressful situation. CONCLUSIONS: we found that women with problematic recovery two months after OASIS experienced their situation as a worse nightmare than expected. Extensive pain resulted in physical and psychological limitations, and crushed expectations of family life. Improved patient information for women with OASIS regarding pain, psychological and personal aspects, sexual function, and subsequent pregnancy delivery is needed. Also, there is a need for clear organizational structures and information to guide help-seeking women to needed care.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 319908 MEDLINE  
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[PMID]: 29524751
[Au] Autor:Yu W; Singh SS; Calhoun S; Zhang H; Zhao X; Yang F
[Ad] Address:School of Health Management and Education, Capital Medical University, Beijing, China; Medical Affairs, Pfizer Investment Co., Ltd, Beijing, China.
[Ti] Title:Generalized anxiety disorder in urban China: Prevalence, awareness, and disease burden.
[So] Source:J Affect Disord;234:89-96, 2018 Feb 21.
[Is] ISSN:1573-2517
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Limited published research has quantified the Generalized Anxiety Disorder (GAD) prevalence and its burden in China. This study aimed to fill in the knowledge gap and to evaluate the burden of GAD among adults in urban China. METHODS: This study utilized existing data from the China National Health and Wellness Survey (NHWS) 2012-2013. Prevalence of self-reported diagnosed and undiagnosed GAD was estimated. Diagnosed and undiagnosed GAD respondents were compared with non-anxious respondents in terms of health-related quality of life (HRQoL), resource utilization, and work productivity and activity impairment using multivariate generalized linear models. A multivariate logistic model assessed the risk factors for GAD. RESULTS: The prevalence of undiagnosed/diagnosed GAD was 5.3% in urban China with only 0.5% of GAD respondents reporting a diagnosis. Compared with non-anxious respondents, both diagnosed and undiagnosed GAD respondents had significantly lower HRQoL, more work productivity and activity impairment, and greater healthcare resource utilization in the past six months. Age, gender, marital status, income level, insurance status, smoking, drinking and exercise behaviors, and comorbidity burdens were significantly associated with GAD. LIMITATIONS: This was a patient-reported study; data are therefore subject to recall bias. The survey was limited to respondents in urban China; therefore, these results focused on urban China and may be under- or over-estimating GAD prevalence in China. Causal inferences cannot be made given the cross-sectional nature of the study. CONCLUSIONS: GAD may be substantially under-diagnosed in urban China. More healthcare resources should be invested to alleviate the burden of GAD.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 319908 MEDLINE  
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[PMID]: 29524680
[Au] Autor:van den Brink AMA; Gerritsen DL; de Valk MMH; Mulder AT; Oude Voshaar RC; Koopmans RTCM
[Ad] Address:De Waalboog, 'Joachim en Anna', Center for Specialized Geriatric Care, Postbus 31071, 6503 CB, Nijmegen, The Netherlands; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Primary and Community Care, Postbus 9101, 6500 HB, Nijmegen, The Netherlands. Electronic a
[Ti] Title:What do nursing home residents with mental-physical multimorbidity need and who actually knows this? A cross-sectional cohort study.
[So] Source:Int J Nurs Stud;81:89-97, 2018 Feb 26.
[Is] ISSN:1873-491X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Aging societies will bring an increase in the number of long-term care residents with mental-physical multimorbidity. To optimize care for these residents, it is important to study their care needs, since unmet needs lower quality of life. To date, knowledge about care needs of residents with mental-physical multimorbidity is limited. The aim of this study was to explore (un)met care needs of residents with mental-physical multimorbidity and determinants of unmet needs. METHODS: Cross-sectional cohort study among 141 residents with mental-physical multimorbidity without dementia living in 17 geronto-psychiatric nursing home units across the Netherlands. Data collection consisted of chart review, semi-structured interviews, (brief) neuropsychological testing, and self-report questionnaires. The Camberwell Assessment of Need for the Elderly (CANE) was used to rate (un)met care needs from residents' and nursing staff's perceptions. Descriptive and multivariate regression analyses were conducted. RESULTS: Residents reported a mean number of 11.89 needs (SD 2.88) of which 24.2% (n = 2.88, SD 2.48) were unmet. Nursing staff indicated a mean number of 14.73 needs (SD 2.32) of which 10.8% (n = 1.59, SD 1.61) were unmet. According to the residents, most unmet needs were found in the social domain as opposed to the psychological domain as reported by the nursing staff. Different opinions between resident and nursing staff about unmet needs was most common in the areas accommodation, company, and daytime activities. Further, nearly half of the residents indicated 'no need' regarding behavior while the nursing staff supposed that the resident did require some kind of support. Depression, anxiety and less care dependency were the most important determinants of unmet needs. CONCLUSIONS: Systematic assessment of care needs showed differences between the perspectives of resident and nursing staff. These should be the starting point of a dialogue between them about needs, wishes and expectations regarding care. This dialogue can subsequently lead to the most optimal individually tailored care plan. To achieve this, nurses with effective communication and negotiation skills, are indispensable.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  5 / 319908 MEDLINE  
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[PMID]: 29524655
[Au] Autor:Huang J; Li G; Qian X; Xu G; Zhao Y; Huang J; Liu Q; He T; Guo X
[Ad] Address:Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, 38 Xueyuan Road, 100191 Beijing, China. Electronic address: jing_huang@bjmu.edu.cn.
[Ti] Title:The burden of ischemic heart disease related to ambient air pollution exposure in a coastal city in South China.
[So] Source:Environ Res;164:255-261, 2018 Mar 07.
[Is] ISSN:1096-0953
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Air pollution is considered one of the most important risk factors for ischemic heart disease (IHD), which is a major public health concern. The disease burden of IHD has continued to rise in China in the past two decades. However, epidemiological studies examining the associations between air pollution and IHD have been scarce in China, and the only studies were conducted in severe air pollution areas, where air pollution levels seriously exceed the World Health Organization Air Quality Guidelines. Whether the influence of air pollution on IHD in areas with relatively low levels of air pollution differs from the influence of high pollution levels in heavily studied areas was unknown until now. Furthermore, the estimation of the disease burden of IHD related to air pollution has been very limited. METHODS: We conducted a time-series study to estimate the short-term burden of ambient air pollution on IHD using the indicator of years of life lost (YLL), based on 10 322 IHD deaths from 2011 to 2015 in Ningbo, a coastal city in South China. RESULTS: The mean concentrations of fine particle (PM ), sulfur dioxide (SO ) and nitrogen dioxide (NO ) were 49.58 µg/m , 21.34 µg/m and 43.41 µg/m , respectively. A 10 µg/m increase in PM , SO and NO was associated with changes in YLL of 0.71 (95%CI: - 0.21,1.64), 3.31 (95%CI: 0.78, 5.84), and 2.27 (95%CI: 0.26, 4.28) years, respectively. Relatively stronger impacts were found for gaseous pollutants than PM . A larger increase in YLL was found in the younger population than in the older population for NO exposure. In addition, estimations of the effects of SO and NO on YLL were higher for males than females. SO exposure was positively associated with YLL in widowed group. CONCLUSIONS: The findings highlighted the importance of stringent air pollution control, especially for gaseous pollutants. Furthermore, using the indicator of YLL, considering the occurrence of death at different ages, provided more information for resource allocation and protection of vulnerable populations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  6 / 319908 MEDLINE  
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[PMID]: 29524588
[Au] Autor:Taran S; Conti J; Routhier F; Latimer-Cheung AE; Noreau L; Sweet SN
[Ad] Address:McGill University, Faculty of Education, Department of Kinesiology and Physical Education, 475 Av. Des Pins O., H2S 1S4, Montreal, Quebec, Canada; Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), 2275 Laurier Ave., H2H 2N8, Montreal, Quebec. Electronic address: sam
[Ti] Title:Leisure time physical activity, perception of impact of pain and life satisfaction after spinal cord injury.
[So] Source:Ann Phys Rehabil Med;, 2018 Mar 07.
[Is] ISSN:1877-0665
[Cp] Country of publication:Netherlands
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  7 / 319908 MEDLINE  
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[PMID]: 29524577
[Au] Autor:Javanrouh N; Daneshpour MS; Soltanian AR; Tapak L
[Ad] Address:Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: n.Javanroh@umsha.ac.ir.
[Ti] Title:Kernel machine SNP set analysis provides new insight into the association between obesity and polymorphisms located on the chromosomal 16q.12.2 region: Tehran Lipid and Glucose Study.
[So] Source:Gene;, 2018 Mar 07.
[Is] ISSN:1879-0038
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Obesity is a serious health problem that leads to low quality of life and early mortality. To the purpose of prevention and gene therapy for such a worldwide disease, genome wide association study is a powerful tool for finding SNPs associated with increased risk of obesity. To conduct an association analysis, kernel machine regression is a generalized regression method, has an advantage of considering the epistasis effects as well as the correlation between individuals due to unknown factors. MATERIALS AND METHODS: In this study, information of the people who participated in Tehran cardio-metabolic genetic study was used. They were genotyped for the chromosomal region, evaluation 986 variations located at 16q12.2; build 38hg. Kernel machine regression and single SNP analysis were used to assess the association between obesity and SNPs genotyped data. RESULTS: We found that associated SNP sets with obesity, were almost in the FTO (P = 0.01), AIKTIP (P = 0.02) and MMP2 (P = 0.02) genes. Moreover, two SNPs, i.e., rs10521296 and rs11647470, showed significant association with obesity using kernel regression (P = 0.02). CONCLUSION: In conclusion, significant sets were randomly distributed throughout the region with more density around the FTO, AIKTIP and MMP2 genes. Furthermore, two intergenic SNPs showed significant association after using kernel machine regression. Therefore, more studies have to be conducted to assess their functionality or precise mechanism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  8 / 319908 MEDLINE  
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[PMID]: 29524517
[Au] Autor:Hong JM; Lee SM
[Ad] Address:School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic of Korea.
[Ti] Title:Heme oxygenase-1 protects liver against ischemia/reperfusion injury via phosphoglycerate mutase family member 5-mediated mitochondrial quality control.
[So] Source:Life Sci;, 2018 Mar 07.
[Is] ISSN:1879-0631
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:AIMS: Heme oxygenase-1 (HO-1), an endogenous cytoprotective enzyme, is reported that can be localized in mitochondria under stress, contributing to preserve mitochondrial function. Mitochondrial quality control (QC) is essential to cellular health and recovery linked with redox homeostasis. Recent studies reported that phosphoglycerate mutase family member (PGAM) 5, a mitochondria-resident phosphatase, plays critical role in mitochondrial homeostasis. Therefore, we aim to investigate cytoprotective mechanisms of HO-1 in I/R-induced hepatic injury focusing on mitochondrial QC associated with PGAM5 signaling. MAIN METHODS: Mice were subjected to 60 min of hepatic ischemia followed by 6 h reperfusion and were pretreated twice with hemin (HO-1 inducer, 30 mg/kg) or zinc protoporphyrin (ZnPP; HO-1 inhibitor, 10 mg/kg) 16 and 3 h before ischemia. KEY FINDINGS: I/R increased hepatic and mitochondrial HO activity, which was augmented by hemin. I/R-induced hepatocellular and mitochondrial damages were attenuated by hemin and augmented by ZnPP. Meanwhile, I/R increased mitochondrial biogenesis, as evidenced by increased mitochondrial DNA contents and mitochondrial transcription factor A protein expression. Hemin augmented these results. I/R impaired mitophagy, as indicated by decreases in Parkin protein expression and the number of mitophagic vacuoles. These changes were attenuated by hemin. Hemin attenuated the I/R-induced increase in mitochondrial fission-related protein, dynamin-related protein 1, and the decrease in PGAM5 protein expression. Furthermore, PGAM5 siRNA abolished the effect of HO-1 on mitochondrial QC in HepG2 cells subjected to hypoxia/reoxygenation. SIGNIFICANCE: Our findings suggest that HO-1 protects against I/R-induced hepatic injury via regulation of mitochondrial QC by PGAM5 signaling.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  9 / 319908 MEDLINE  
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[PMID]: 29524454
[Au] Autor:Hoffman EP; Riddle V; Siegler MA; Dickerson D; Backonja M; Kramer WG; Nagaraju K; Gordish-Dressman H; Damsker JM; McCall JM
[Ad] Address:ReveraGen BioPharma, Rockville, MD USA; Department of Pharmaceutical Sciences, School of Pharmacy, Binghamton University - SUNY, Binghamton, NY USA. Electronic address: ericphoffman@gmail.com.
[Ti] Title:Phase 1 trial of vamorolone, a first-in-class steroid, shows improvements in side effects via biomarkers bridged to clinical outcomes.
[So] Source:Steroids;, 2018 Mar 07.
[Is] ISSN:1878-5867
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Glucocorticoid drugs are highly effective anti-inflammatory agents, but chronic use is associated with extensive pharmacodynamic safety concerns that have a considerable negative impact on patient quality of life. PURPOSE: Vamorolone (VBP15) is a first-in-class steroidal multi-functional drug that shows potent inhibition of pro-inflammatory NFkB pathways via high-affinity binding to the glucocorticoid receptor, high affinity antagonism for the mineralocorticoid receptor, and membrane stabilization properties. Pre-clinical data in multiple mouse models of inflammation showed retention of anti-inflammatory efficacy, but loss of most or all side effects. EXPERIMENTAL: Approach We report first-in-human Phase 1 clinical trials (86 healthy adult males), with single ascending doses (0.1 - 20.0 mg/kg), and multiple ascending doses (1.0 - 20.mg/kg/day; 14 days treatment). KEY RESULTS: Vamorolone was well-tolerated at all dose levels. Vamorolone showed pharmacokinetic and metabolism profiles similar to prednisone. Biomarker studies showed loss of side effects of traditional glucocorticoid drugs (bone fragility, metabolic disturbance, immune suppression). Suppression of the adrenal axis was 10-fold less than prednisone. The crystallographic structure of vamorolone was solved, and compared to prednisone and dexamethasone. There was overlap in structure, but differences in conformation at the C-ring where glucocorticoids interact with Asn564 of the glucocorticoid receptor. The predicted loss of Asn564 binding to vamorolone may underlie the loss of gene transcriptional activity. CONCLUSIONS AND INTERPRETATIONS: Vamorolone is a dissociative steroid that retains high affinity binding and nuclear translocation of both glucocorticoid (agonist) and mineralocorticoid (antagonist) receptors, but does not show pharmacodynamic safety concerns of existing glucocorticoid drugs at up to 20 mg/kg/day.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  10 / 319908 MEDLINE  
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[PMID]: 29520390
[Au] Autor:Takazawa N; Fujisaki A; Yoshimura Y; Tsujimura A; Horie S
[Ad] Address:Department of Urology, Juntendo University School of Medicine, Tokyo, Japan.
[Ti] Title:Short-term outcomes of the transvaginal minimal mesh procedure for pelvic organ prolapse.
[So] Source:Investig Clin Urol;59(2):133-140, 2018 Mar.
[Is] ISSN:2466-054X
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Purpose: This study aimed to evaluate the clinical outcomes and complications of transvaginal minimal mesh repair without using commercially available kits for treatment of pelvic organ prolapse (POP). Materials and Methods: This retrospective cohort study involved 91 women who underwent surgical management of POP with originally designed small mesh between July 2014 and August 2015. This mesh is 56% smaller than the mesh widely used in Japan, and it has only two arms delivered into each right and left sacrospinous ligament. The main study outcome was the anatomic cure rate defined as recurrence of POP quantification (POP-Q) stage II or more. We also assessed changes in the overactive bladder symptom score (OABSS) and prolapse quality of life questionnaire (P-QOL) and evaluated adverse events. Finally, we compared patient backgrounds between the patients with and without recurrence. Results: Prolapse recurred in 10 of 91 patients (11.0%), and all patients with recurrence were diagnosed as POP-Q stage II. As adverse events, only mesh erosion occurred in two (2.2%) and pelvic pain in one (1.1%) of the 91 patients. The OABSS and P-QOL were significantly improved by the operation. When we compared patient backgrounds between the patients with and without recurrence, body mass index was the only factor influencing affecting recurrence. Conclusions: Transvaginal minimal mesh repair resulted in successful outcomes with low mesh-related complications and anatomic recurrence at one year. Furthermore, significant improvement in QOL was offered by this procedure. Our minimal mesh technique should be considered as one treatment option for the management of POP.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.4111/icu.2018.59.2.133


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