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[PMID]: 29524507
[Au] Autor:Tan Y; Martin RC
[Ad] Address:Rice University, Department of Psychology, 6100 Main Street, Houston, TX 77005. Electronic address: Yingying.tan@mpi.nl.
[Ti] Title:Verbal Short-term Memory Capacities and Executive Function in Semantic and Syntactic Interference Resolution during Sentence Comprehension: Evidence from Aphasia.
[So] Source:Neuropsychologia;, 2018 Mar 07.
[Is] ISSN:1873-3514
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This study examined the role of verbal short-term memory (STM) and executive function (EF) underlying semantic and syntactic interference resolution during sentence comprehension for persons with aphasia (PWA) with varying degrees of STM and EF deficits. Semantic interference was manipulated by varying the semantic plausibility of the intervening NP as subject of the verb and syntactic interference was manipulated by varying whether the NP was another subject or an object. Nine PWA were assessed on sentence reading times and on comprehension question performance. PWA showed exaggerated semantic and syntactic interference effects relative to healthy age-matched control subjects. Importantly, correlational analyses showed that while answering comprehension questions, PWA' semantic STM capacity related to their ability to resolve semantic but not syntactic interference. In contrast, PWA' EF abilities related to their ability to resolve syntactic but not semantic interference. Phonological STM deficits were not related to the ability to resolve either type of interference. The results for semantic STM are consistent with prior findings indicating a role for semantic but not phonological STM in sentence comprehension, specifically with regard to maintaining semantic information prior to integration. The results for syntactic interference are consistent with the recent findings suggesting that EF is critical for syntactic processing.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 143542 MEDLINE  
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[PMID]: 29524467
[Au] Autor:McCrackin SD; Itier RJ
[Ad] Address:Department of Psychology, University of Waterloo, Waterloo, Canada. Electronic address: sdmccrac@uwaterloo.ca.
[Ti] Title:Is it about me? Time-course of self-relevance and valence effects on the perception of neutral faces with direct and averted gaze.
[So] Source:Biol Psychol;, 2018 Mar 07.
[Is] ISSN:1873-6246
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Most face processing research has investigated how we perceive faces presented by themselves, but we view faces everyday within a rich social context. Recent ERP research has demonstrated that context cues, including self-relevance and valence, impact electrocortical and emotional responses to neutral faces. However, the time-course of these effects is still unclear, and it is unknown whether these effects interact with the face gaze direction, a cue that inherently contains self-referential information and triggers emotional responses. We primed direct and averted gaze neutral faces (gaze manipulation) with contextual sentences that contained positive or negative opinions (valence manipulation) about the participants or someone else (self-relevance manipulation). In each trial, participants rated how positive or negative, and how affectively aroused, the face made them feel. Eye-tracking ensured sentence reading and face fixation while ERPs were recorded to face presentations. Faces put into self-relevant contexts were more arousing than those in other-relevant contexts, and elicited ERP differences from 150-750 ms post-face, encompassing EPN and LPP components. Self-relevance interacted with valence at both the behavioural and ERP level starting 150 ms post-face. Finally, faces put into positive, self-referential contexts elicited different N170 ERP amplitudes depending on gaze direction. Behaviourally, direct gaze elicited more positive valence ratings than averted gaze during positive, self-referential contexts. Thus, self-relevance and valence contextual cues impact visual perception of neutral faces and interact with gaze direction during the earliest stages of face processing. The results highlight the importance of studying face processing within contexts mimicking the complexities of real world interactions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29511566
[Au] Autor:Dawood OT; Hassali MA; Saleem F; Ibrahim IR
[Ad] Address:Department of Medical ServicesMinistry of Science and TechnologyBaghdadIraq.
[Ti] Title:Assessment of self-reporting reading of medicine's labels and the resources of information about medicines in general public in Malaysia.
[So] Source:Pharmacol Res Perspect;6(2):e00387, 2018 Apr.
[Is] ISSN:2052-1707
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This study was undertaken to assess the people's self-reported reading of medicine labels and its associated factors and to assess the sources of information about medicines among general public. A cross-sectional study was carried out among general public in the State of Penang, Malaysia. A total of 888 participants were conveniently selected and completed the survey. A self-administered questionnaire was used to obtain the data from all the participants. Most of the participants (74.2%) reported that they have adequate information about medicines provided on their medicine labels. In addition, 86.9% of them reported that they read their medicine's label for the directions of usage and 84.3% for the dosage instruction. However, 42.1% of the participants do not read their medicine's label for the active ingredients, and 33% of them do not read their medicine's label for the safety information. In addition, 36.5% of the respondents did not read the label of medicine for the symptoms which can be used for. However, females, Malay respondents, and higher education level (college/university) were more likely to self-reported the reading medicine's label. Females were more likely to read the labels of medicines compared with males (OR = 1.6, 95% CI 1.20-2.13, = .001). The reading of medicine labels was predicted by females, Malay respondents, and higher educated people. Health educational programs are needed to clarify label's information that can help in concept of patient safety.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.1002/prp2.387

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[PMID]: 29510707
[Au] Autor:Ullrich A; Voigt L; Baumann S; Weymar F; John U; Dörr M; Ulbricht S
[Ad] Address:University Medicine Greifswald, Institute of Social Medicine and Prevention, Walther-Rathenau-Str. 48, D-17475, Greifswald, Germany. antje.ullrich@uni-greifswald.de.
[Ti] Title:A cross-sectional analysis of the associations between leisure-time sedentary behaviors and clustered cardiometabolic risk.
[So] Source:BMC Public Health;18(1):327, 2018 Mar 06.
[Is] ISSN:1471-2458
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The aim of this study was to conduct a comprehensive investigation of the association between different types of leisure-time sedentary behavior (watching television, using a computer, reading and socializing) and clustered cardiometabolic risk in apparently healthy adults aged 40 to 65 years. METHODS: One hundred seventy-three participants from the general population (64% women; mean age = 54.4 years) consented to attend a cardiovascular examination program and to complete a questionnaire on leisure-time sedentary behaviors. Waist circumference, blood pressure, glucose, triglycerides, and high-density lipoprotein cholesterol of non-fasting blood samples were assessed, and a clustered cardiometabolic risk score [CMRS] was calculated. Data were collected between February and July 2015. Associations between leisure-time sedentary behaviors and CMRS were analyzed using linear and quantile regression, adjusted for socio-demographic variables and other types of leisure-time sedentary behavior (model 1) and additionally, adjusted for leisure-time physical activity and traveling in motor vehicles (model 2). RESULTS: Linear regression revealed that there was a positive association between watching television and CMRS (model 1: b = 0.27 [CI: 0.03; 0.52]; model 2: b = 0.30 [CI: 0.05; 0.56]). In addition, quantile regression analysis revealed that using a computer was negatively associated with the 50th (model 1: b = - 0.43 [CI: -0.79; - 0.07]) and the 75th percentiles (model 1: b = - 0.71 [CI: -1.27; - 0.14]) of CMRS. Reading and socializing were not associated with CMRS. CONCLUSIONS: Watching television was positively associated with a clustered cardiometabolic risk score, while time spent using a computer revealed inconsistent findings. Our results give reason to consider different types of behaviors in which individuals are sedentary and the associations between these behaviors and cardiometabolic risk, supporting the need for behavior-specific assessments as well as public health recommendations to maintain or enhance adults' health. TRIAL REGISTRATION: Clinical trial registration number: NCT02990039 , Retrospectively registered (December 12, 2016).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Data-Review
[do] DOI:10.1186/s12889-018-5213-3

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[PMID]: 29506476
[Au] Autor:Ip JCH; Mu H; Chen Q; Sun J; Ituarte S; Heras H; Van Bocxlaer B; Ganmanee M; Huang X; Qiu JW
[Ad] Address:HKBU Institute of Research and Continuing Education, Shenzhen, China.
[Ti] Title:AmpuBase: a transcriptome database for eight species of apple snails (Gastropoda: Ampullariidae).
[So] Source:BMC Genomics;19(1):179, 2018 Mar 05.
[Is] ISSN:1471-2164
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Gastropoda, with approximately 80,000 living species, is the largest class of Mollusca. Among gastropods, apple snails (family Ampullariidae) are globally distributed in tropical and subtropical freshwater ecosystems and many species are ecologically and economically important. Ampullariids exhibit various morphological and physiological adaptations to their respective habitats, which make them ideal candidates for studying adaptation, population divergence, speciation, and larger-scale patterns of diversity, including the biogeography of native and invasive populations. The limited availability of genomic data, however, hinders in-depth ecological and evolutionary studies of these non-model organisms. RESULTS: Using Illumina Hiseq platforms, we sequenced 1220 million reads for seven species of apple snails. Together with the previously published RNA-Seq data of two apple snails, we conducted de novo transcriptome assembly of eight species that belong to five genera of Ampullariidae, two of which represent Old World lineages and the other three New World lineages. There were 20,730 to 35,828 unigenes with predicted open reading frames for the eight species, with N50 (shortest sequence length at 50% of the unigenes) ranging from 1320 to 1803 bp. 69.7% to 80.2% of these unigenes were functionally annotated by searching against NCBI's non-redundant, Gene Ontology database and the Kyoto Encyclopaedia of Genes and Genomes. With these data we developed AmpuBase, a relational database that features online BLAST functionality for DNA/protein sequences, keyword searching for unigenes/functional terms, and download functions for sequences and whole transcriptomes. CONCLUSIONS: In summary, we have generated comprehensive transcriptome data for multiple ampullariid genera and species, and created a publicly accessible database with a user-friendly interface to facilitate future basic and applied studies on ampullariids, and comparative molecular studies with other invertebrates.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Data-Review
[do] DOI:10.1186/s12864-018-4553-9

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[PMID]: 29501636
[Au] Autor:Suhail M; Sohrab SS; Qureshi A; Tarique M; Abdel-Hafiz H; Al-Ghamdi K; Qadri I
[Ad] Address:King Fahd Medical Research Center, King Abdulaziz University, PO Box 80216, Jeddah 21589, Saudi Arabia.
[Ti] Title:Association of HCV mutated proteins and host SNPs in the development of hepatocellular carcinoma.
[So] Source:Infect Genet Evol;60:160-172, 2018 Mar 01.
[Is] ISSN:1567-7257
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Hepatitis C virus plays a significant role in the development of hepatocellular carcinoma (HCC) globally. The pathogenic mechanisms of hepatocellular carcinoma with HCV infection are generally linked with inflammation, cytokines, fibrosis, cellular signaling pathways, and liver cell proliferation modulating pathways. HCV encoded proteins (Core, NS3, NS4, NS5A) interact with a broad range of hepatocytes derived factors to modulate an array of activities such as cell signaling, DNA repair, transcription and translational regulation, cell propagation, apoptosis, membrane topology. These four viral proteins are also implicated to show a strong conversion potential in tissue culture. Furthermore, Core and NS5A also trigger the accretion of the ß-catenin pathway as a common target to contribute viral induced transformation. There is a strong association between HCV variants within Core, NS4, and NS5A and host single nucleotide polymorphisms (SNPs) with the HCC pathogenesis. Identification of such viral mutants and host SNPs is very critical to determine the risk of HCC and response to antiviral therapy. In this review, we highlight the association of key variants, mutated proteins, and host SNPs in development of HCV induced HCC. How such viral mutants may modulate the interaction with cellular host machinery is also discussed.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  7 / 143542 MEDLINE  
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[PMID]: 29499381
[Au] Autor:Chabaud A; Eschalier B; Zullian M; Plan-Paquet A; Aubreton S; Saragaglia D; Descamps S; Coudeyre E
[Ad] Address:Service de médecine physique et de réadaptation, INRA, université Clermont-Auvergne, CHU de Clermont-Ferrand, Clermont Ferrand, France.
[Ti] Title:Mixed qualitative and quantitative approach for validating an information booklet before total hip arthroplasty.
[So] Source:Ann Phys Rehabil Med;, 2018 Feb 27.
[Is] ISSN:1877-0665
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Providing patients with validated information before total hip arthroplasty may help lessen discrepancies between patients' expectations and the surgical result. This study sought to validate an information booklet for candidates for hip arthroplasty by using a mixed qualitative and quantitative approach based on a panel of patients and a sample of healthcare professionals. METHODS: We developed a booklet in accordance with the standard methods and then conducted focus groups to collect the opinions of a sample of multidisciplinary experts involved in the care of patients with hip osteoarthritis. The number of focus groups and experts was determined according to the data saturation principle. A panel of patients awaiting hip arthroplasty or those in the immediate post-operative period assessed the booklet with self-reporting questionnaires (knowledge, beliefs, and expectations) and semi-structured interviews. RESULTS: All experts and both patient groups validated the booklet in terms of content and presentation. Semi-structured interviews were uninformative, especially for post-operative patients. Reading the booklet significantly (P<0.001) improved the knowledge scores in both groups, with no intergroup differences, but did not affect beliefs in either patient group. Only pre-operative patients significantly changed their expectations. CONCLUSION: Our mixed qualitative and quantitative approach allowed us to validate a booklet for patients awaiting hip arthroplasty, taking into account the opinions of both patients and healthcare professionals.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  8 / 143542 MEDLINE  
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[PMID]: 29477442
[Au] Autor:Taylor CM; Olulade OA; Luetje MM; Eden GF
[Ad] Address:Center for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
[Ti] Title:An fMRI study of coherent visual motion processing in children and adults.
[So] Source:Neuroimage;173:223-239, 2018 Mar 02.
[Is] ISSN:1095-9572
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:There is a large corpus of brain imaging studies examining the dorsal visual pathway, especially area V5/MT during visual motion perception. However, despite evidence suggesting a protracted development of the dorsal visual stream, and a role of this pathway in neurodevelopmental disorders, V5/MT has not been characterized developmentally. Further, experiential factors such as reading acquisition may play a modulating role in any age-dependent changes. Here we used a coherent visual motion detection task to examine V5/MT activity and connectivity in typical participants in two studies: a Cross- Sectional Study comparing adults and children; and a Longitudinal Study of 2nd graders followed into 3rd grade. In the Cross-Sectional Study, a whole-brain analysis revealed no differences between the two groups, whereas a region of interest (ROI) approach identified greater activation in left (right trending) V5/MT in adults compared to children. However, when we measured V5/MT activation individually for each participant, children and adults showed no difference in the location or intensity of activation, although children did exhibit relatively larger extent of V5/MT activation bilaterally. There was also relatively greater functional connectivity in the children between left and right occipitotemporal cortex, including V5/MT. The Longitudinal Study revealed no changes in V5/MT activation for any measures of activation or functional connectivity from 2nd to 3rd grade. Finally, there was no evidence of an association between reading and V5/MT over time, nor predictive power of V5/MT activity for later reading. Together, our results indicate similar V5/MT activity across age groups, with relatively greater extent of V5/MT activation and functional connectivity in children relative to adults, bilaterally. These differences were not apparent over the time course of one year, suggesting that these developmental changes occur over a more protracted period.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29476812
[Au] Autor:de Melo AB; de Souza WM; Acrani GO; Carvalho VL; Romeiro MF; Tolardo AL; da Silva SP; Cardoso JF; de Oliveira Chiang J; da Silva Gonçalves Vianez JL; do Socorro da Silva Azevedo R; Figueiredo LTM; da Costa Vasconcelos PF; Nunes MRT; de Almeida Medeiros DB
[Ad] Address:Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará, Brazil.
[Ti] Title:Genomic characterization and evolution of Tacaiuma orthobunyavirus (Peribunyaviridae family) isolated in Brazil.
[So] Source:Infect Genet Evol;60:71-76, 2018 Feb 21.
[Is] ISSN:1567-7257
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Tacaiuma virus (TCMV) is antigenically characterized as a member of the Anopheles A complex in the Orthobunyavirus genus, Peribunyaviridae family (Bunyavirales order). Clinically, the TCMV infection is characterized by acute febrile illness with myalgia and arthralgia lasting three to five days. However, the genomic and evolutionary aspect of this virus has not been elucidated. In this study, we described the complete coding sequences of three segments of two TCMV strains isolated in Brazil and three complete coding sequences of the small segment of three TCMV strains. All the strains sequenced in this study showed the typical genomic organization of orthobunyaviruses that infect vertebrates, except for the absence of the open reading frame that encodes the well-described non-structural small protein. This study presents the genomic and evolutionary characterization of TCMV strains and would be helpful for diagnostic purposes and epidemiology.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  10 / 143542 MEDLINE  
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[PMID]: 29458094
[Au] Autor:Lu M; Yang C; Li M; Yi Q; Lu G; Wu Y; Qu C; Wang L; Song L
[Ad] Address:Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian 116023, China; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian 116023, China.
[Ti] Title:A conserved interferon regulation factor 1 (IRF-1) from Pacific oyster Crassostrea gigas functioned as an activator of IFN pathway.
[So] Source:Fish Shellfish Immunol;76:68-77, 2018 Feb 17.
[Is] ISSN:1095-9947
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Interferon regulatory factors (IRFs), a family of transcription factors with a novel helix-turn-helix DNA-binding motif, play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes. In the present study, an interferon regulation factor 1 was identified from oyster Crassostrea gigas (designated CgIRF-1), and its immune function was characterized to understand the regulatory mechanism of interferon system against viral infection in invertebrates. The open reading frame (ORF) of CgIRF-1 was 990 bp, encoding a polypeptide of 329 amino acids with a typical IRF domain (also known as DNA-binding domain). The mRNA transcripts of CgIRF-1 were detected in all the tested tissues with the highest expression level in hemocyte. CgIRF-1 protein was distributed in both nucleus and cytoplasm of the oyster hemocyte. The mRNA expression of CgIRF-1 in hemocytes was significantly up-regulated at 48 h after poly (I:C) stimulation (p < 0.05). The recombinant CgIRF-1 (rCgIRF-1) could interact with classically IFN-stimulated response elements (ISRE) in vitro. The relative luciferase activity of interferon-like protein promotor reporter gene (pGL-CgIFNLP promotor) was significantly (p < 0.05) enhanced in HEK293T cell after transfection of CgIRF-1. These results indicated that CgIRF-1 could bind ISRE and regulate the expression of CgIFNLP as a transcriptional regulatory factor, and participated in the antiviral immune response of oysters.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher


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