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[PMID]: 29055721
[Au] Autor:Maurya AK; Mohanty S; Pal A; Chanotiya CS; Bawankule DU
[Ad] Address:Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow 226015, India; Department of Biotechnology, Sai Nath University, Ranchi 835219, India.
[Ti] Title:The essential oil from Citrus limetta Risso peels alleviates skin inflammation: In-vitro and in-vivo study.
[So] Source:J Ethnopharmacol;212:86-94, 2017 Oct 19.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Citrus fruit peels are traditionally used in folk medicine for the treatment of skin disorders but it lacks proper pharmacological intervention. Citrus limetta Risso (Rutaceae) is an important commercial fruit crops used by juice processing industries in all continents. Ethnopharmacological validation of an essential oil isolated from its peels may play a key role in converting the fruit waste materials into therapeutic value added products. AIM OF THE STUDY: To evaluate the chemical and pharmacological (in-vitro and in-vivo) profile of essential oil isolated from Citrus limetta peels (Clp-EO) against skin inflammation for its ethnopharmacological validation. MATERIALS AND METHODS: Hydro-distilled essential oil extracted from Citrus limetta peels (Clp-EO) was subjected to gas chromatography (GC) analysis for identification of essential oil constituents and its anti-inflammatory evaluation through in vitro and in vivo models. RESULTS: Chemical fingerprint of Clp-EO revealed the presence of monoterpene hydrocarbon and limonene is the major component. Pre-treatment of Clp-EO to the macrophages was able to inhibit the production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1ß) in LPS-induced inflammation as well as the production of reactive oxygen species (ROS) in H O -induced oxidative stress. In in-vivo study, topical application of Clp-EO was also able to reduce the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear thickness, ear weight, lipid peroxidation, pro-inflammatory cytokines production and ameliorate the histological damage in the ear tissue. In-vitro and in-vivo toxicity study indicate that it is safe for topical application on skin. CONCLUSION: These findings suggested the preventive potential of Clp-EO for the treatment of inflammation linked skin diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:Publisher

  2 / 1407 MEDLINE  
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[PMID]: 28762091
[Au] Autor:Sarker SD; Nahar L
[Ad] Address:Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK. S.Sarker@ljmu.ac.uk.
[Ti] Title:Progress in the Chemistry of Naturally Occurring Coumarins.
[So] Source:Prog Chem Org Nat Prod;106:241-304, 2017.
[Is] ISSN:2191-7043
[Cp] Country of publication:Austria
[La] Language:eng
[Ab] Abstract:Coumarins are the largest group of 1-benzopyran derivatives found in plants. The initial member of this group of compounds, coumarin (2H-1-benzopyran-2-one), a fragrant colorless compound, was first isolated from the Tonka bean (Dipteryx odorata, family Fabaceae) in 1820. The name coumarin comes from a French term for the tonka bean, coumarou. Since the discovery of coumarin, several of its derivatives, with umbelliferone (7-hydroxycoumarin) being the most common one, have been reported from various natural sources. The families Apiaceae, Asteraceae, and Rutaceae are the three major plant sources of coumarins.Generally, these plant secondary metabolites may be classified into simple, simple prenylated, simple geranylated, furano, pyrano, sesquiterpenyl and oligomeric coumarins. Using this standard classification, this chapter aims to present an account on the advances of the chemistry of naturally occurring coumarins, as reported in the literature during the period 2013-2015.In Sect. 1, the coumarins are introduced and their generic biosynthetic route discussed briefly. In Sect. 2, the largest of the three sections, various classes of natural coumarins are detailed, with their relevant structures and the citation of appropriate references. In a concluding section, it is highlighted that during the last 3 years, more than 400 coumarins have been reported in the literature. Many of these coumarins have been re-isolations of known compounds from known or new sources, most often associated with various biological activities. However, a substantial number of coumarins bearing new skeletons, especially dimers, prenylated furanocoumarins, sesquiterpenyl, and some unusual coumarins were also reported during the period of 2013-2015.Coumarin chemistry remains one of the major interest areas of phytochemists, especially because of their structural diversity and medicinal properties, along with the wide-ranging bioactivities of these compounds, inclusive of analgesic, anticoagulant anti-HIV, anti-inflammatory, antimicrobial, antineoplastic, antioxidant, and immunomodulatory effects. Despite significant advancements in the extraction, isolation, structure elucidation and bioactivity testing of naturally occurring coumarins, only a marginal advancement has been observed recently in relation to the study of their biosynthesis.
[Mh] MeSH terms primary: Coumarins/chemistry
Plant Extracts/chemistry
[Mh] MeSH terms secundary: Anti-Infective Agents
Antineoplastic Agents
Antioxidants
Apiaceae
Asteraceae
Coumarins/pharmacology
Molecular Structure
Plant Extracts/pharmacology
Rutaceae
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Anti-Infective Agents); 0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Coumarins); 0 (Plant Extracts)
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[Js] Journal subset:IM
[Da] Date of entry for processing:170801
[St] Status:MEDLINE
[do] DOI:10.1007/978-3-319-59542-9_3

  3 / 1407 MEDLINE  
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[PMID]: 29084672
[Au] Autor:Sabir SM; Rocha JBT; Boligon AA; Athayde ML
[Ad] Address:Department of Chemistry, University of Poonch, Rawalakot, Azad Kashmir, Pakistan.
[Ti] Title:Hepatoprotective activity and phenolic profile of Zanthoxylum alatum Roxb. fruit extract.
[So] Source:Pak J Pharm Sci;30(5):1551-1556, 2017 Sep.
[Is] ISSN:1011-601X
[Cp] Country of publication:Pakistan
[La] Language:eng
[Ab] Abstract:Zanthoxylum alatum Roxb. (Rutaceae) is a medicinal plant, which abundantly grows in the hilly areas of Pakistan. In the present study, the hepatoprotective activity of the Z. alatum whole fruit was evaluated. The hepatoprotective effect of the aqueous extracts was studied on mice liver damage using a single dose of paracetamol (640 mg/kg) orally by monitoring biochemical parameters. Pre-treatment of mice with Z. alatum (100 mg/kg) aqueous extract orally for four days prevented the paracetamol induced rise in serum transaminases (ALT and AST), restored the altered levels of antioxidant enzyme (catalase), thiobarbituric acid reactive substances (TBARS), non-protein thiol and ascorbic acid to near normal levels. The major phenolic acids, some flavonoid aglycone and glycosides were identified in fruit by high performance liquid chromatography. Ellagic acid (24.57±0.01mg/g), chlorogenic acid (10.65±0.01mg/g), gallic acid (9.15±0.02mg/g), chrysin (16.81±0.03), quercetin (16.81±0.03mg/g) and epicatechin (10.93±0.01) were prédominant in infusion of Z. alatum. The result substianted the hepatoprotective activity of Z. alatum which may be associated with its potential use in liver disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[St] Status:In-Data-Review

  4 / 1407 MEDLINE  
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[PMID]: 28990382
[Au] Autor:Liu SM; Wang SJ; Song SY; Zou Y; Wang JR; Sun BY
[Ad] Address:College of Science, Northwest A&F University, Yangling 712100, China.
[Ti] Title:Characteristic differences in essential oil composition of six Zanthoxylum bungeanum Maxim. (Rutaceae) cultivars and their biological significance.
[So] Source:J Zhejiang Univ Sci B;18(10):917-920, 2017 Oct..
[Is] ISSN:1862-1783
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:Great variations have been found in composition and content of the essential oil of Zanthoxylum bungeanum Maxim. (Rutaceae), resulting from various factors such as harvest time, drying and extraction methods (Huang et al., 2006; Shao et al., 2013), solvent and herbal parts used (Zhang, 1996; Cao and Zhang, 2010; Wang et al., 2011). However, in terms of artificial introduction and cultivation, there is little research on the chemical composition of essential oil extracted from Z. bungeanum Maxim. cultivars, which have been introduced from different origins. In this study, the composition and content of essential oil from six cultivars (I-VI) have been investigated. They were introduced and cultivated for 11 years in the same cultivation conditions. Cultivars were as followings: Qin'an (I) cultivar originally introduced from Qin'an City in Gansu Province; Dahongpao A (II) from She County in Hebei Province; Dahongpao B (III) from Fuping County; Dahongpao C (IV) from Tongchuan City; Meifengjiao (V) from Feng County; and, Shizitou (VI) from Hancheng City, in Shaanxi Province, China. This research is expected to provide a theoretical basis for further introduction, cultivation, and commercial development of Z. bungeanum Maxim.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171024
[Lr] Last revision date:171024
[St] Status:In-Process
[do] DOI:10.1631/jzus.B1700232

  5 / 1407 MEDLINE  
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[PMID]: 29058421
[Au] Autor:Lee HJ; Koo HJ; Lee J; Lee DY; Giang VNL; Kim M; Shim H; Park JY; Yoo KO; Sung SH; Yang TJ
[Ti] Title:Authentication of Zanthoxylum Species Based on Integrated Analysis of Complete Chloroplast Genome Sequences and Metabolite Profiles.
[So] Source:J Agric Food Chem;, 2017 Oct 23.
[Is] ISSN:1520-5118
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We performed chloroplast genome sequencing and comparative analysis of two Rutaceae species, Zanthoxylum schinifolium (Korean pepper tree) and Z. piperitum (Japanese pepper tree), which are medicinal and culinary crops in Asia. We identified more than 837 single nucleotide polymorphisms and 103 insertions/deletions (InDels) based on a comparison of the two chloroplast genomes and developed seven DNA markers derived from five tandem repeats and two InDel variations that discriminated between Korean Zanthoxylum species. Metabolite profile analysis pointed to three metabolic groups, one with Korean Z. piperitum samples, one with Korean Z. schinifolium samples and the last containing all the tested Chinese Zanthoxylum species samples, which are considered to be Z. bungeanum based on our results. Two markers were capable of distinguishing among these three groups. The chloroplast genome sequences identified in this study represent a valuable genomics resource for exploring diversity in Rutaceae, and the molecular markers will be useful for authenticating dried Zanthoxylum berries in the marketplace.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[St] Status:Publisher
[do] DOI:10.1021/acs.jafc.7b04167

  6 / 1407 MEDLINE  
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[PMID]: 29057808
[Au] Autor:Zhang M; Wang J; Zhu L; Li T; Jiang W; Zhou J; Peng W; Wu C
[Ad] Address:College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. garita119@163.com.
[Ti] Title:Zanthoxylum bungeanum Maxim. (Rutaceae): A Systematic Review of Its Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicology.
[So] Source:Int J Mol Sci;18(10), 2017 Oct 18.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Maxim. (Rutaceae) is a popular food additive and traditional Chinese herbal medicine commonly named in China. This plant is widely distributed in Asian countries. The aim of this paper is to provide a systematic review on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of this plant. Furthermore, the possible development and perspectives for future research on this plant are also discussed. To date, over 140 compounds have been isolated and identified from , including alkaloids, terpenoids, flavonoids, and free fatty acids. The extracts and compounds have been shown to possess wide-ranging biological activity, such as anti-inflammatory and analgesic effects, antioxidant and anti-tumor effects, antibacterial and antifungal effects, as well as regulatory effects on the gastrointestinal system and nervous system, and other effects. As a traditional herbal medicine, has been widely used to treat many diseases, especially digestive disorders, toothache, stomach ache, and diarrhea. Many traditional usages of this plant have been validated by present investigations. However, further research elucidating the structure-function relationship among chemical compounds, understanding the mechanism of unique sensation, as well as exploring new clinical effects and establishing criteria for quality control for should be further studied.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[St] Status:In-Process

  7 / 1407 MEDLINE  
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[PMID]: 28946189
[Au] Autor:Ostrowska K; Olejarz W; Wrzosek M; Gluszko A; Nowicka G; Szczepanski M; Materek IB; Koziol AE; Struga M
[Ad] Address:Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warszawa, Poland. Electronic address: kostrowska@wum.edu.pl.
[Ti] Title:Anticancer effects of O-aminoalkyl derivatives of alloxanthoxyletin and seselin.
[So] Source:Biomed Pharmacother;95:1412-1424, 2017 Nov.
[Is] ISSN:1950-6007
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Seselin and alloxanthoxyletin, naturally occurring pyranocoumarins, were recently isolated from a number of plant sources, such as family of Rutaceae. It was previously reported that their natural and synthetic derivatives show cytotoxic and antitumor activity. In the present study new series of O-aminoalkyl substituted alloxanthoxyletins and seselins were synthesized and evaluated for their anticancer toxicity. Microwave assisted synthesis was used, and the structures of the compounds were confirmed by H NMR, C NMR and MS spectroscopic data. The molecular and crystal structure of 3a was analyzed by single crystal X-ray diffraction. Alloxanthoxyletin derivatives 2a, 2b, and 2d showed the highest cytotoxic potential against HTB-140 cells with IC of 2.48, 2.80 and 2.98µM, respectively. In vitro drug sensitivity testing in HaCaT, A549 and HTB-140 cells were also performed. Tumor cells showed a higher sensitivity to tested compounds than normal cells. Compounds 2a, 2b and 2d inhibited cell migration and exerted stronger effect on A549 and HTB-140 cells than on HaCaT cells. In order to explain the basic mechanism of cell death induction we have investigated the effect of derivatives 2a, 2b and 2d on early and late apoptosis using annexin V-FITC/7-AAD flow cytometry analysis. Derivatives 2a and 2b were much more potent inducers of early apoptosis in HTB-140 cells compared to HaCaT and A549 cells.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171024
[Lr] Last revision date:171024
[St] Status:In-Process

  8 / 1407 MEDLINE  
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[PMID]: 28813645
[Au] Autor:Tan JW; Israf DA; Md Hashim NF; Cheah YK; Harith HH; Shaari K; Tham CL
[Ad] Address:Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43300, Malaysia.
[Ti] Title:LAT is essential for the mast cell stabilising effect of tHGA in IgE-mediated mast cell activation.
[So] Source:Biochem Pharmacol;144:132-148, 2017 Nov 15.
[Is] ISSN:1873-2968
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Mast cells play a central role in the pathogenesis of allergic reaction. Activation of mast cells by antigens is strictly dependent on the influx of extracellular calcium that involves a complex interaction between signalling molecules located within the cells. We have previously reported that tHGA, an active compound originally isolated from a local shrub known as Melicope ptelefolia, prevented IgE-mediated mast cell activation and passive systemic anaphylaxis by suppressing the release of interleukin-4 (IL-4) and tumour necrosis factor (TNF)-α from activated rat basophilic leukaemia (RBL)-2H3 cells. However, the mechanism of action (MOA) as well as the molecular target underlying the mast cell stabilising effect of tHGA has not been previously investigated. In this study, DNP-IgE-sensitised RBL-2H3 cells were pre-treated with tHGA before challenged with DNP-BSA. To dissect the MOA of tHGA in IgE-mediated mast cell activation, the effect of tHGA on the transcription of IL-4 and TNF-α mRNA was determined using Real Time-Polymerase Chain Reaction (qPCR) followed by Calcium Influx Assay to confirm the involvement of calcium in the activation of mast cells. The protein lysates were analysed by using Western Blot to determine the effect of tHGA on various important signalling molecules in the LAT-PLCγ-MAPK and PI3K-NFκB pathways. In order to identify the molecular target of tHGA in IgE-mediated mast cell activation, the LAT and LAT2 genes in RBL-2H3 cells were knocked-down by using RNA interference to establish a LAT/LAT2 competition model. The results showed that tHGA inhibited the transcription of IL-4 and TNF-α as a result of the suppression of calcium influx in activated RBL-2H3 cells. The results from Western Blot revealed that tHGA primarily inhibited the LAT-PLCγ-MAPK pathway with partial inhibition on the PI3K-p65 pathway without affecting Syk. The results from RNAi further demonstrated that tHGA failed to inhibit the release of mediators associated with mast cell degranulation under the LAT/LAT2 competition model in the absence of LAT. Collectively, this study concluded that the molecular target of tHGA could be LAT and may provide a basis for the development of a mast cell stabiliser which targets LAT.
[Mh] MeSH terms primary: Adaptor Proteins, Signal Transducing/metabolism
Immunoglobulin E/physiology
Mast Cells/drug effects
Mast Cells/metabolism
Membrane Proteins/metabolism
Phosphoproteins/metabolism
Plant Extracts/pharmacology
Rutaceae
[Mh] MeSH terms secundary: Animals
Cell Line, Tumor
Dose-Response Relationship, Drug
Plant Extracts/isolation & purification
Rats
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Adaptor Proteins, Signal Transducing); 0 (Lat protein, rat); 0 (Membrane Proteins); 0 (Phosphoproteins); 0 (Plant Extracts); 37341-29-0 (Immunoglobulin E)
[Em] Entry month:1710
[Cu] Class update date: 171019
[Lr] Last revision date:171019
[Js] Journal subset:IM
[Da] Date of entry for processing:170816
[St] Status:MEDLINE

  9 / 1407 MEDLINE  
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[PMID]: 28961723
[Au] Autor:Langdon KW; Rogers ME
[Ad] Address:Department of Entomology and Nematology, Citrus Research and Education Center, University of Florida, 700 Experiment Station Road, Lake Alfred, FL 33850.
[Ti] Title:Neonicotinoid-Induced Mortality of Diaphorina Citri (Hemiptera: Liviidae) is Affected by Route of Exposure.
[So] Source:J Econ Entomol;110(5):2229-2234, 2017 Oct 01.
[Is] ISSN:1938-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The use of neonicotinoids in citrus (Rutaceae) has increased substantially to help manage the Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae), a vector of the devastating citrus disease, huanglongbing (HLB). In citrus pest management programs, neonicotinoids are most often applied to the soil as a drench and move through xylem channels from the roots into the foliage. We developed a novel assay to quantify the dose required to kill D. citri following ingestion and compare it with the dose required to kill by contact. The LC50 of the laboratory strain for ingestion of imidacloprid, thiamethoxam, and clothianidin were each approximately 10-fold greater than the respective LC50 by contact exposure. Four field populations were tested to validate comparative exposure of the laboratory strain to imidacloprid and determine the relative susceptibility of field populations to imidacloprid by exposure through ingestion and contact. The contact assay exhibited low (<10) RR50 values for the Vero Beach and Labelle populations when compared to the ingestion assay method. High (>10) RR50 values were observed for the Lake Placid and Lake Alfred populations using the contact and the ingestion method. This research demonstrates that the ingestion assay method described herein is more sensitive in detection of low-level resistance and should be the standard methodology used in monitoring for resistance to systemic insecticides for this global pest. We found D. citri populations with a lower than expected susceptibility to neonicotinoids in the field, which warrants the implementation of resistance management practices to preserve the utility of soil-applied neonicotinoids in citrus.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171019
[Lr] Last revision date:171019
[St] Status:In-Process
[do] DOI:10.1093/jee/tox231

  10 / 1407 MEDLINE  
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[PMID]: 29017021
[Au] Autor:Badawy MEI; Taktak NEM; El-Aswad AF
[Ad] Address:a Faculty of Agriculture, Department of Pesticide Chemistry and Technology , 21545-El-Shatby, Alexandria University , Alexandria , Egypt.
[Ti] Title:Chemical composition of the essential oils isolated from peel of three citrus species and their mosquitocidal activity against Culex pipiens.
[So] Source:Nat Prod Res;:1-6, 2017 Oct 10.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Three essential oils (EOs) were isolated from the peel of citrus fruits Citrus reticulata L., Citrus reticulata chinase Blanco and Citrus sinensis (L.) Osbeck (Family: Rutaceae) and evaluated against Culex pipiens L.1758 (Family: Culicidae). Chemical composition indicated that the EOs were rich in essential phytochemicals including hydrocarbons, monoterpenes and sesquiterpenes. These constituents revealed some variability among the oils displaying interesting chemotypes limonene (35-51%), 1R-α-pinene (1.04-2.5%), γ-terpinene (0.46-5.65%) and sabinene (0.51-5.42%). The toxicity proved that C. sinensis oil had more effect than C. reticulata chinase and C. reticulata oils against larvae (LC = 15.35, 16.11 and 32.84 mg/L, respectively). However, C. reticulate was the most active as fumigant against adults (LC 2.74 µL/L air). The in vivo effect on acetylcholine esterase (AChE), carboxyl esterase (CbE), acid phosphatase (ACP), alkaline phosphatase (ALP), adenosine triphosphatase (ATPase) and glutathione-S-transferase (GST) were also demonstrated. To the best of our knowledge, this is the first report about the chemical composition and mosquitocidal activity of C. reticulata chinase essential oils. Conclusively, the tested essential oils could be used as eco-friendly alternatives in mosquitoes control programme.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171017
[Lr] Last revision date:171017
[St] Status:Publisher
[do] DOI:10.1080/14786419.2017.1378216


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