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[PMID]: 29524920
[Au] Autor:Sakhi AK; Sabaredzovic A; Papadopoulou E; Cequier E; Thomsen C
[Ad] Address:Department of Environmental Exposure and Epidemiology, Division of Infection Control, Environment and Health, Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, 0403 Oslo, Norway. Electronic address: amritkaur.sakhi@fhi.no.
[Ti] Title:Levels, variability and determinants of environmental phenols in pairs of Norwegian mothers and children.
[So] Source:Environ Int;114:242-251, 2018 Mar 07.
[Is] ISSN:1873-6750
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Exposure to environmental phenols including parabens, bisphenols (BPs), oxybenzone/benzophenone-3 (BP-3) and triclosan (TCS) is ubiquitous. Due to evidence of their estrogenic activity, they have been considered as chemicals of concern. The exposure of the Norwegian population to these compounds is presently unknown. AIMS: To measure urinary levels of twelve different environmental phenols including four emerging bisphenols: S, F, B and AF (abbreviated as BPS, BPF, BPB and BPAF, respectively) in a healthy Norwegian population. We have calculated short-term variability, estimated daily intakes and investigated important determinants of exposure. METHODS: Urine samples were collected from mothers (n = 48) and their children (n = 56) during spring/summer 2012 in two counties in Norway. RESULTS: Six environmental phenols namely methyl, ethyl and propyl paraben, BPA, BP-3 and TCS were detected in almost 100% of the urine samples. Among the emerging bisphenols, BPS was detected most frequently in the urine samples (42-48%) followed by BPF (4-15%). Parabens were positively and significantly correlated to each other in both mothers and children. Levels of parabens and BP-3 were higher in mothers compared to children. All mothers and children had lower estimated daily intakes (back calculated from the urinary concentrations) of parabens and BPA than the respective acceptable and tolerable daily intakes (ADIs and TDIs) established by the European Food Safety Authority (EFSA). Observed intraclass correlation coefficients (ICCs) indicated moderate to high reliability of spot urine measurements for all the environmental phenols (ICCs: 0.70-0.97). Use of hair products, deodorants, face and hand creams were significantly associated with higher urinary levels of parabens. CONCLUSIONS: Occurrence of environmental phenols in healthy Norwegian women and children is abundant. Among emerging bisphenols, there is widespread exposure to BPS. A single spot urine sample can be used for estimating short-term exposures of environmental phenols. Urinary levels of parabens were associated with use of PCPs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524873
[Au] Autor:Laslett AM; Jiang H; Chikritzhs T
[Ad] Address:National Drug Research Institute, Curtin University, Bentley, Perth, 6002, Australia; Centre for Alcohol Policy Research, School of Psychology and Public Health, La Trobe University, 3086, Australia; School of Population and Global Health, University of Melbourne, 3000, Australia. Electronic address: anne-marie.laslett@curtin.edu.au.
[Ti] Title:Child injury deaths linked with adult alcohol consumption: A time series analysis.
[So] Source:Drug Alcohol Depend;185:360-366, 2018 Jan 31.
[Is] ISSN:1879-0046
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:OBJECTIVE: This paper aims to quantify the population-level associations between child injury deaths and adult (aged 15+ years) per capita alcohol consumption (PCC) and between child injury deaths and the impact of major alcohol and safety policy changes in Australia. METHODS: All child deaths due to external causes during 1910-2013, and child deaths due specifically to road crashes, assaults, suicide and other external causes, were obtained from the Australian Institute of Health and Welfare. Child (0-14 year) mortality rates were analysed in relation to PCC using an Autoregressive Integrated Moving Average model. RESULTS: A positive association between PCC and overall child external mortality was identified. The estimated coefficient was 0.326 (p = .002), indicating that a 10% decrease in PCC was associated with a 3.3% reduction in child injury mortality. A positive association was identified for road traffic and other child injury mortality, but not assault injuries. The introduction of compulsory seatbelt legislation in combination with random breath testing was associated with a reduction in overall injury and road traffic child mortality. Decreasing the legal drinking age was associated with an increase in the rate of other external-cause child mortality. CONCLUSION: Reducing PCC in Australia is likely to result in a small but significant reduction in the injury mortality rate of children aged 0-14 years.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524870
[Au] Autor:Canaway R; Bismark M; Dunt D; Prang KH; Kelaher M
[Ad] Address:Centre for Health Policy, Melbourne School of Population and Global Health, Level 4, 207 Bouverie Street, The University of Melbourne, 3010, Victoria, Australia. Electronic address: rachel.canaway@unimelb.edu.au.
[Ti] Title:"What is meant by public?": Stakeholder views on strengthening impacts of public reporting of hospital performance data.
[So] Source:Soc Sci Med;202:143-150, 2018 Feb 22.
[Is] ISSN:1873-5347
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Public reporting of hospital performance data is a developing area that is gaining increased attention. This is the first study to explore a range of stakeholder opinions on how such public reporting could be strengthened in Australia. Thirty-four semi-structured interviews were conducted with a purposive sample of expert healthcare consumer, provider and purchaser informants who worked in a variety of senior roles and had knowledge of or involvement in public reporting of hospital data within the public or private healthcare sectors. Informants from all Australian states, territory and national jurisdictions participated. Thematic analysis was used to gain an overview of experts' opinions to inform policy and systems-development for strengthening foundational frameworks for public reporting of health services performance. Themes arising were synthesised to generate explanatory figures to highlight key areas for strengthening public reporting. Our findings suggest that in Australia there is a lack of agreement on what the objectives and who the audience are for public reporting of hospital performance data. Without this shared understanding it is difficult to strengthen frameworks and impacts of public reporting. When developing frameworks for public reporting of hospital data in Australia, more explicit definition of what or who are the 'public' is needed along with identification of barriers, desired impacts, data needs, and data collection/reporting/feedback mechanisms. All relevant stakeholders should be involved in design of public reporting frameworks. Offering multiple systems of public reporting, each tailored to particular audiences, might enable greater impact of reporting towards improved hospital quality and safety, and consumer knowledge to inform treatment decisions. This study provides an overview of perspectives, but further research is warranted to develop PR frameworks that can generate greatest impacts for the needs of various audiences.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524869
[Au] Autor:Melo S
[Ad] Address:Queen's Management School, Queen's University Belfast, Riddel Hall, 185 Stranmillis Road, Belfast, BT9 5EE, Northern Ireland, UK. Electronic address: s.melo@qub.ac.uk.
[Ti] Title:The role of place on healthcare quality improvement: A qualitative case study of a teaching hospital.
[So] Source:Soc Sci Med;202:136-142, 2018 Mar 02.
[Is] ISSN:1873-5347
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:This article examines how the built environment impacts, and is impacted by, healthcare staff day to day practice, care outcomes and the design of new quality and patient safety (Q&PS) projects. It also explores how perceptions of the built environment affect inter-professional dynamics. In doing so, it contributes to the overlooked interplay between the physical, social, and symbolic dimensions associated with a hospital's place. The study draws on 46 in-depth semi-structured interviews conducted at a large teaching hospital in Portugal formed by two buildings. Interview transcripts were analysed inductively using thematic analysis. The major contribution of this study is to advance the understanding of the interactions among the different dimensions of place on Q&PS improvement. For example, findings indicate that some of the characteristics of the physical infrastructure of the hospital have a negative impact on the quality of care provided and/or significantly limit the initiatives that can be implemented to improve it, including refurbishment works. However, decisions on refurbishment works were also influenced by the characteristics of the patient population, hospital budget, etc. Likewise, clinicians' emotional reactions to the limitations of the buildings depended on their expectations of the buildings and the symbolic projections they attributed to them. Nevertheless, differences between clinicians' expectations regarding the physical infrastructure and its actual features influenced clinicians' views on Q&PS initiatives designed by non-clinicians.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  5 / 861028 MEDLINE  
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[PMID]: 29524866
[Au] Autor:Regev G; Martins J; Sheridan MP; Leemhuis J; Thompson J; Miller C
[Ad] Address:Faculty of Medicine, Respiratory Division, University of British Columbia, Vancouver, British Columbia V6H 3Z6, Canada; Bovicor Pharmatech Inc., North Vancouver, British Columbia V7H 2Y4, Canada. Electronic address: gillyr@mail.ubc.ca.
[Ti] Title:Feasibility and preliminary safety of nitric oxide releasing solution as a treatment for bovine mastitis.
[So] Source:Res Vet Sci;118:247-253, 2018 Feb 22.
[Is] ISSN:1532-2661
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Nitric oxide-releasing solution (NORS) is a liquid formulation that releases nitric oxide, a broad spectrum antimicrobial, single electron nitroxide radical. This solution was investigated as a potential antimicrobial treatment for bovine mastitis (BM). Three experiments were performed: a) NORS' effect on Staphylococcus aureus and Escherichia coli in an in vitro model; b) NORS' effect on milk obtained from dairy cows showing symptoms of clinical mastitis; and c) the consequences of administering NORS to healthy milking cattle using a dose-escalating in vivo study. Metabolite concentrations were estimated in their blood for methaemoglobin and nitrite; also, milk nitrite concentration and somatic cell count (SCC) were measured to study possible mammary gland inflammation following treatment. NORS lowered the bacterial concentration in all infected samples, in a time- and milk-diluted dependant fashion. Blood methemoglobin concentrations following treatment were all within the normal range for cattle. However, blood and milk nitrite concentrations increased initially but, during the next 24 h, returned to normal range, as did SCC, without any clinical signs of mammary gland inflammation. NORS, if shown to be effective, could be an alternative treatment for mastitis with a shorter clearance time.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  6 / 861028 MEDLINE  
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[PMID]: 29524856
[Au] Autor:Kawaida H; Kimura A; Watanabe M; Akaike H; Hosomura N; Kawaguchi Y; Amemiya H; Sudo M; Kono H; Matsuda M; Fujii H; Ichikawa D; Fukasawa M; Takahashi E; Sano K; Inoue T
[Ad] Address:First Department of Surgery, Faculty of Medicine, University of Yamanashi, Japan. Electronic address: kawaidah@yamanashi.ac.jp.
[Ti] Title:Successful laparoscopic partial gastrectomy and spleen-preserving distal pancreatectomy for gastric duplication cyst connecting with the pancreatic tail.
[So] Source:Int J Surg Case Rep;44:176-180, 2018 Feb 24.
[Is] ISSN:2210-2612
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Gastrointestinal duplication cyst is a congenital rare disease that may occur in any region from mouth to anus. Among them, gastric duplication cysts are very rare. CASE REPORT: Here we report A 23-year-old Japanese man who visited our hospital to evaluate an abdominal tumor. Abdominal computed tomography showed a well-circumscribed homogenous low-density mass measuring 6.2  6.0 cm between the pancreatic tail and the upper posterior wall on the gastric greater curvature, and the mass seemed to originate from the pancreatic tail. We found intraoperatively that the mass adhered to the stomach and pancreatic tail strongly, so we performed laparoscopic partial gastrectomy and spleen-preserving distal pancreatectomy. Pathological findings showed that the lining epithelium of the cystic mass consisted of the gastric foveolar epithelium with fundic glands. Furthermore, the pancreatic tissue of the pancreatic tail and the muscular layer of the cystic mass were intermingled. DISCUSSION: GDCs are usually diagnosed at a younger age and in adults, they are very rare. Therefore, surgical resection is considered to be the best treatment due to the difficulty of diagnosis, and also that it mimics a pancreatic cystic tumor, and malignant transformation. Complete resection of the cyst is the ideal technique and laparoscopic surgery should be selected whenever possible. CONCLUSION: We experienced a case of GDC continuous to both stomach and pancreatic tail. Laparoscopic surgery is safety and useful even if GDC is continuous with both the stomach and the pancreas.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524849
[Au] Autor:Di Martino A; Trusova ME; Postnikov PS; Sedlarik V
[Ad] Address:Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr.Tomas Bati, 5678, 76001, Zlin, Czech Republic; Research School in Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, Lenin Av. 30, 634050 Tomsk, Russian Federation. Electronic address: dimartin
[Ti] Title:Branched poly (lactic acid) microparticles for enhancing the 5-aminolevulinic acid phototoxicity.
[So] Source:J Photochem Photobiol B;181:80-88, 2018 Mar 03.
[Is] ISSN:1873-2682
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:An innovative microcarrier based on a carboxy-enriched and branched polylactic acid derivative was developed to enhance the in vitro phototoxicity of the photosensitizer and prodrug 5-aminolevulinic. Microparticles, prepared by double emulsion technique and loaded with the prodrug were carefully characterized and the effect of the polymer structure on the chemical, physical and biological properties of the final product was evaluated. Results showed that microparticles have a spherical shape and ability to allocate up to 30 g of the photosensitizer per mg of carrier despite their difference in solubility. Release studies performed in various simulated physiological conditions demonstrate the influence of the branched structure and the presence of the additional carboxylic groups on the release rate and the possibility to modulate it. In vitro assays conducted on human epithelial adenocarcinoma cells proved the not cytotoxicity of the carriers in a wide range of concentrations. The hemocompatibility and surface proteins adsorption were evaluated at different microparticles concentrations to evaluate the safety and estimate the possible microparticles residential time in the bloodstream. The advantages, of loading 5-aminolevulinic acid in the prepared carrier has been deeply described in terms of enhanced phototoxicity, compared to the free 5-aminolevulinic acid formulation after irradiation with light at 635 nm. The obtained results demonstrate the advantages of the prepared derivative compared to the linear polylactide for future application in photodynamic therapy based on the photosensitizer 5-aminolevulinic acid.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  8 / 861028 MEDLINE  
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[PMID]: 29524825
[Au] Autor:Galindo N; Yubero E; Nicols JF; Varea M; Crespo J
[Ad] Address:Atmospheric Pollution Laboratory (LCA), Department of Applied Physics, Miguel Hernndez University, Avenida de la Universidad S/N, 03202 Elche, Spain. Electronic address: ngalindo@umh.es.
[Ti] Title:Characterization of metals in PM and PM and health risk evaluation at an urban site in the western Mediterranean.
[So] Source:Chemosphere;201:243-250, 2018 Feb 28.
[Is] ISSN:1879-1298
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PM and PM samples collected in the urban center of Elche during two years were analyzed by Energy Dispersive X-Ray Fluorescence in order to determine the concentrations of the following metals: K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Sr and Ba. The influence of traffic and Saharan dust intrusions on PM levels and metal content was studied in this work. The results indicate that the coarse fraction was affected more by variations in traffic intensity than the submicron fraction. The concentrations of Ca, commonly used as a tracer of road dust, showed the highest decreases during the weekends due to the reduction in traffic-induced resuspension. In contrast, Saharan events had a greater impact on the levels of other metals such as Ti and Fe, significantly affecting their seasonal variability. High concentrations of V and Ni compared with the values found at larger urban areas were observed. This could be attributed to a significant contribution from soils, Saharan dust and even ship emissions. Enrichment factors calculated using Ti as a reference element indicate that Zn and Cu are predominantly emitted by anthropogenic activities. In fact, Saharan dust intrusions had a minor influence on the average concentrations of these metals. Non-carcinogenic health hazards associated with exposure to airborne metals were lower than the safety threshold (hazard quotient < 1). Carcinogenic risks for Cr (VI) and Ni were between 10 and 10 and, therefore, within the range considered acceptable by the US EPA.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524822
[Au] Autor:Noszczynska M; Piotrowska-Seget Z
[Ad] Address:Department of Microbiology, University of Silesia, Jagiellonska 28, 40-032 Katowice, Poland. Electronic address: magdalena.noszczynska@us.edu.pl.
[Ti] Title:Bisphenols: Application, occurrence, safety, and biodegradation mediated by bacterial communities in wastewater treatment plants and rivers.
[So] Source:Chemosphere;201:214-223, 2018 Feb 28.
[Is] ISSN:1879-1298
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Numerous data indicate that most of bisphenols (BPs) are endocrine disrupters and exhibit cytotoxicity, neurotoxicity, genotoxicity and reproductive toxicity against vertebrates. Nevertheless, they are widely applied in material production what result in their ubiquitous occurrence in ecosystems. While BPA is the most frequently detected in environment, BPAF, BPF and BPS are also often found. Ecosystem particularly exposed to BPs pollution is industrial and municipal wastewater being a common source of BPA in river waters. Different techniques to remove BPs from these ecosystems have been applied, among which biodegradation seems to be the most effective. In this review the current state of knowledge in the field of BPs application, distribution in the environment, effects on animal and human health, and biodegradation mediated by bacterial populations in wastewater treatment plants and rivers is presented.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  10 / 861028 MEDLINE  
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[PMID]: 29524816
[Au] Autor:Jiang J; Ma D; Zou N; Yu X; Zhang Z; Liu F; Mu W
[Ad] Address:College of Plant Protection, Shandong Agricultural University, Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, Tai'an, Shandong 271018, PR China.
[Ti] Title:Concentrations of imidacloprid and thiamethoxam in pollen, nectar and leaves from seed-dressed cotton crops and their potential risk to honeybees (Apis mellifera L.).
[So] Source:Chemosphere;201:159-167, 2018 Feb 27.
[Is] ISSN:1879-1298
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Neonicotinoid insecticides (NIs) have recently been recognized as co-factors in the decline of honeybee colonies because most neonicotinoids are systemic and can transfer into the pollen and nectar of many pollinated crops. In this study, we collected pollen, nectar and leaves from a cotton crop treated with imidacloprid and thiamethoxam to measure the residue levels of these two NIs at different application doses during the flowering period. Then, the residual data were used to assess the risk posed by the systemic insecticides to honeybees following mandated methods published by the European Food Safety Authority (EFSA), and a highly toxic risk to honeybees was highlighted. Imidacloprid was found in both pollen and nectar samples, whereas thiamethoxam was found in 90% of pollen samples and over 60% of nectar samples. Analysis of the pollen and nectar revealed residual amounts of imidacloprid ranging from 1.61 to 64.58 ng g in the pollen and from not detected (ND) to 1.769 ng g in the nectar. By comparison, the thiamethoxam concentrations in pollen and nectar ranged from ND to 14.521 ng g and from ND to 4.285 ng g , respectively. The results of this study provide information on the transfer of two NIs from seed treatment to areas of the plant and provides an understanding of the potential exposure of the bee and other pollinators to systemic insecticides.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher


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