Database : MEDLINE
Search on : secretin [Words]
References found : 9139 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 914 go to page                         

  1 / 9139 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29288273
[Au] Autor:Pendharkar SA; Singh RG; Chand SK; Cervantes A; Petrov MS
[Ad] Address:School of Medicine, University of Auckland, Auckland, New Zealand.
[Ti] Title:Pro-inflammatory cytokines after an episode of acute pancreatitis: associations with fasting gut hormone profile.
[So] Source:Inflamm Res;67(4):339-350, 2018 Apr.
[Is] ISSN:1420-908X
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Pro-inflammatory cytokines, such as interleukin (IL)-6, tumour necrosis factor (TNF)α, and monocyte chemoattractant protein (MCP)-1, are often elevated in individuals after acute pancreatitis but what determines their levels is poorly understood. Gut hormones have emerged as possible modulators of inflammatory response. The aim was to investigate the associations between pro-inflammatory cytokines and a comprehensive panel of gut hormones after an episode of acute pancreatitis. MATERIALS AND METHODS: Fasting blood samples were collected to measure cytokines (IL-6, TNFα, and MCP-1) and gut hormones (cholecystokinin, gastric inhibitory peptide (GIP), ghrelin, glicentin, glucagon-like peptide-1, oxyntomodulin, peptide YY, secretin, and vasoactive intestinal peptide). A series of linear regression analyses was conducted and four statistical models were used to adjust for patient- and pancreatitis-related covariates. RESULTS: A total of 83 individuals were recruited. GIP and peptide YY were significantly (p < 0.001) associated with IL-6, TNFα, MCP-1, consistently in all the four models. Every 1 ng/mL change in GIP resulted in a 16.2, 3.2, and 50.8% increase in IL-6, TNFα, and MCP-1, respectively, in the most adjusted model. Every 1 ng/mL change in peptide YY resulted in a 7.0, 2.4, and 32.1% increase in IL-6, TNFα, and MCP-1, respectively, in the most adjusted model. GIP independently contributed 29.0-36.5% and peptide YY - 17.4-48.9% to circulating levels of the studied pro-inflammatory cytokines. The other seven studied gut hormones did not show consistently significant associations with pro-inflammatory cytokines. CONCLUSIONS: GIP and peptide YY appear to be involved in perpetuation of subclinical inflammation following an episode of acute pancreatitis, which is known to play an important role in the pathogenesis of blood glucose derangements. These findings advance the understanding of mechanisms underlying diabetes of the exocrine pancreas and have translational implications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1007/s00011-017-1125-4

  2 / 9139 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29517421
[Au] Autor:O'Malley Y; Rotti PG; Thornell IM; Vanegas Calderón OG; Febres-Aldana C; Durham K; Yao J; Li X; Zhu Z; Norris AW; Zabner J; Engelhardt JF; Uc A
[Ad] Address:Department of Pediatrics, University of Iowa, United States.
[Ti] Title:DEVELOPMENT OF A POLARIZED PANCREATIC DUCTULAR CELL EPITHELIA FOR PHYSIOLOGICAL STUDIES.
[So] Source:J Appl Physiol (1985);, 2018 Mar 08.
[Is] ISSN:1522-1601
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Pancreatic ductular epithelial cells comprise the majority of duct cells in pancreas, control cystic fibrosis transmembrane conductance regulator (CFTR)-dependent bicarbonate [HCO ] secretion, but are difficult to grow as a polarized monolayer. Using NIH-3T3-J2 fibroblast feeder cells and a Rho-associated kinase inhibitor, we produced well-differentiated and polarized porcine pancreatic ductular epithelial cells. Cells grown on semipermeable filters at air-liquid interface (ALI) developed typical epithelial cell morphology and stable transepithelial resistance (TER), expressed epithelial cell markers (zona occludens-1 and beta catenin), duct cell markers (SOX-9 and CFTR), but no acinar (amylase) or islet cell (chromogranin) markers. Polarized cells were studied in Ussing chambers bathed in Krebs Ringer [HCO ] solution, at 37 C gassed with 5% CO to measure short circuit currents (I ). Ratiometric measurement of extracellular pH was performed using fluorescent SNARF-conjugated dextran at 5% CO . Cells demonstrated a baseline Isc (12.2+3.2 µA/cm ) that increased significantly in response to apical forskolin/IBMX (∆I : 35.4{plus minus}3.8, p<0.001) or basolateral secretin (∆I : 31.4{plus minus}2.5 µA/cm , p<0.001), both of which increase cellular levels of cAMP. Subsequent addition of apical GlyH-101, a CFTR inhibitor decreased the current (∆I : 20.4{plus minus}3.8, p<0.01). Extracellular pH and bicarbonate concentration increased significantly after forskolin/IBMX (pH: 7.18{plus minus}0.23 vs 7.53{plus minus}0.19; [HCO ] in mM 14.5{plus minus}5.9 vs 31.8{plus minus}13.4, p<0.05 for both). We demonstrate the development of a polarized pancreatic ductular epithelial cell epithelia with CFTR-dependent bicarbonate secretion in response to secretin and cAMP. This model is highly relevant as porcine pancreas physiology is very similar to humans and pancreatic damage in cystic fibrosis pig model recapitulates that of humans.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1152/japplphysiol.00043.2018

  3 / 9139 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29474932
[Au] Autor:McVeigh P; McCammick E; McCusker P; Wells D; Hodgkinson J; Paterson S; Mousley A; Marks NJ; Maule AG
[Ad] Address:Parasitology & Pathogen Biology, The Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK. Electronic address: paul.mcveigh@qub.ac.uk.
[Ti] Title:Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes.
[So] Source:Int J Parasitol Drugs Drug Resist;8(1):87-103, 2018 Feb 05.
[Is] ISSN:2211-3207
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:G protein-coupled receptors (GPCRs) are established drug targets. Despite their considerable appeal as targets for next-generation anthelmintics, poor understanding of their diversity and function in parasitic helminths has thwarted progress towards GPCR-targeted anti-parasite drugs. This study facilitates GPCR research in the liver fluke, Fasciola hepatica, by generating the first profile of GPCRs from the F. hepatica genome. Our dataset describes 147 high confidence GPCRs, representing the largest cohort of GPCRs, and the largest set of in silico ligand-receptor predictions, yet reported in any parasitic helminth. All GPCRs fall within the established GRAFS nomenclature; comprising three glutamate, 135 rhodopsin, two adhesion, five frizzled, one smoothened, and one secretin GPCR. Stringent annotation pipelines identified 18 highly diverged rhodopsins in F. hepatica that maintained core rhodopsin signatures, but lacked significant similarity with non-flatworm sequences, providing a new sub-group of potential flukicide targets. These facilitated identification of a larger cohort of 76 related sequences from available flatworm genomes, representing new members of existing groups (PROF1/Srfb, Rho-L, Rho-R, Srfa, Srfc) of flatworm-specific rhodopsins. These receptors imply flatworm specific GPCR functions, and/or co-evolution with unique flatworm ligands, and could facilitate the development of exquisitely selective anthelmintics. Ligand binding domain sequence conservation relative to deorphanised rhodopsins enabled high confidence ligand-receptor matching of seventeen receptors activated by acetylcholine, neuropeptide F/Y, octopamine or serotonin. RNA-Seq analyses showed expression of 101 GPCRs across various developmental stages, with the majority expressed most highly in the pathogenic intra-mammalian juvenile parasites. These data identify a broad complement of GPCRs in F. hepatica, including rhodopsins likely to have key functions in neuromuscular control and sensory perception, as well as frizzled and adhesion/secretin families implicated, in other species, in growth, development and reproduction. This catalogue of liver fluke GPCRs provides a platform for new avenues into our understanding of flatworm biology and anthelmintic discovery.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:Publisher

  4 / 9139 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29263097
[Au] Autor:Filloux A; Voulhoux R
[Ad] Address:Imperial College London, Department of Life Sciences, MRC-CMBI, London, United Kingdom a.filloux@imperial.ac.uk.
[Ti] Title:Multiple Structures Disclose the Secretins' Secrets.
[So] Source:J Bacteriol;200(5), 2018 Mar 01.
[Is] ISSN:1098-5530
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Bacterial secretins are outer membrane proteins that provide a path for secreted proteins to access the cell exterior/surface. They are one of the core components of secretion machines and are found in type II and type III secretion systems (T2SS and T3SS, respectively). The secretins comprise giant ring-shaped homo-oligomers whose precise atomic organization was only recently deciphered thanks to spectacular developments in cryo-electron microscopy (cryo-EM) imaging techniques.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Data-Review

  5 / 9139 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29374614
[Au] Autor:Vanga RR; Tansel A; Sidiq S; El-Serag HB; Othman M
[Ad] Address:Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX. Electronic address: rohini.vanga@gmail.com.
[Ti] Title:Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency - Systematic Review and Meta-analysis.
[So] Source:Clin Gastroenterol Hepatol;, 2018 Jan 25.
[Is] ISSN:1542-7714
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND & AIMS: Tests to quantify fecal levels of chymotrypsin like elastase family member 3 (CELA3 or elastase-1) in feces are widely used to identify patients with exocrine pancreatic insufficiency (EPI). However, the diagnostic accuracy of this test, an ELISA, is not clear. We performed a systematic review and meta-analysis to determine the accuracy of measurement of fecal elastase-1 in detection of EPI. METHODS: We searched PubMed, Embase, and reference lists for articles through November 2016 describing studies that compared fecal level of elastase-1 with results from a reference standard, direct method (secretin stimulation test), or indirect method (measurement of fecal fat) for detection of EPI. Sensitivity and specificity values were pooled statistically using bivariate diagnostic meta-analysis. RESULTS: We included total of 428 cases of EPI and 673 individuals without EPI (controls), from 14 studies, in the meta-analysis. The assay for elastase-1, compared to secretin stimulation test, identified patients with pancreatic insufficiency with a pooled sensitivity value of 0.77 (95% CI, 0.58-0.89) and specificity value of 0.88 (95% CI, 0.78-0.93). In an analysis of 345 cases of EPI and 312 controls, from 6 studies, the fecal elastase-1 assay identified patients with EPI with a pooled sensitivity value of 0.96 (95% CI, 0.79-0.99) and specificity value of 0.88 (95% CI, 0.59-0.97), compared to quantitative fecal fat estimation. In patients with low pre-test probability of EPI (5%), the fecal elastase-1 assay would have a false-negative rate of 1.1% and a false-positive rate of 11%, indicating a high yield in ruling out EPI but not in detection of EPI. In contrast, in patients with high pre-test probability of EPI (40%), approximately 10% of patients with EPI would be missed (false negatives). CONCLUSION: In a systematic review and meta-analysis of studies that compared fecal level of elastase-1 for detection of EPI, we found that normal level of elastase-1 (above 200 mcg/g) can rule out EPI in patients with a low probability of this disorder (such as those with irritable bowel syndrome with diarrhea). However, in these patients, an abnormal level of elastase-1 (below 200 mcg/g) has a high false-positive rate.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher

  6 / 9139 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29206061
[Au] Autor:Chamokova B; Bastati N; Poetter-Lang S; Bican Y; Hodge JC; Schindl M; Matos C; Ba-Ssalamah A
[Ad] Address:1 Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna/Vienna General Hospital , Vienna , Austria.
[Ti] Title:The clinical value of secretin-enhanced MRCP in the functional and morphological assessment of pancreatic diseases.
[So] Source:Br J Radiol;:20170677, 2018 Feb 05.
[Is] ISSN:1748-880X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) provides a non-invasive way, with which, to evaluate pancreatic duct (PD) anatomy and exocrine pancreatic function. S-MRCP can be added to the routine pancreas MR examination in equivocal cases. Moreover, it can detect subtle PD involvement, allowing diagnosis of early, rather than end-stage, pancreatic diseases. Although S-MRCP is a valuable non-invasive diagnostic method, it is only performed in a few centres due to relative high cost. Furthermore, less familiarity with its indications, the examination technique, and image interpretation also contribute to its limited use. Thus, the purpose of this article is to explain secretin's mechanism of action, the examination technique, the clinically relevant indications, the advantages, and limitations. Finally, we will focus on image analysis and its role in achieving an early and accurate diagnosis of specific pancreatic and PD diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180205
[Lr] Last revision date:180205
[St] Status:Publisher
[do] DOI:10.1259/bjr.20170677

  7 / 9139 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29280731
[Au] Autor:D'Imprima E; Salzer R; Bhaskara RM; Sánchez R; Rose I; Kirchner L; Hummer G; Kühlbrandt W; Vonck J; Averhoff B
[Ad] Address:Department of Structural Biology, Max Planck Institute of Biophysics, Frankfurt, Germany.
[Ti] Title:Cryo-EM structure of the bifunctional secretin complex of .
[So] Source:Elife;6, 2017 12 27.
[Is] ISSN:2050-084X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Secretins form multimeric channels across the outer membrane of Gram-negative bacteria that mediate the import or export of substrates and/or extrusion of type IV pili. The secretin complex of is an oligomer of the 757-residue PilQ protein, essential for DNA uptake and pilus extrusion. Here, we present the cryo-EM structure of this bifunctional complex at a resolution of ~7 Å using a new reconstruction protocol. Thirteen protomers form a large periplasmic domain of six stacked rings and a secretin domain in the outer membrane. A homology model of the PilQ protein was fitted into the cryo-EM map. A crown-like structure outside the outer membrane capping the secretin was found not to be part of PilQ. Mutations in the secretin domain disrupted the crown and abolished DNA uptake, suggesting a central role of the crown in natural transformation.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1712
[Cu] Class update date: 180201
[Lr] Last revision date:180201
[St] Status:In-Process

  8 / 9139 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29376952
[Au] Autor:Achkasov EE; Pugaev AV; Nabiyeva ZG; Kalachev SV
[Ad] Address:Sechenov First Moscow State Medical University, Moscow, Russia.
[Ti] Title:Vliianie raznykh sposobov nutritivnoi podderzhki na sekretsiiu zhelezy pri ostrom pankreatite. [Effect of different nutritional support on pancreatic secretion in acute pancreatitis].
[So] Source:Khirurgiia (Mosk);(1):14-20, 2018.
[Is] ISSN:0023-1207
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:AIM: To develop and justify optimal nutritional support in early phase of acute pancreatitis (AP). MATERIAL AND METHODS: 140 AP patients were enrolled. They were divided into groups depending on nutritional support: group I (n=70) - early enteral tube feeding (ETF) with balanced mixtures, group II (n=30) - early ETF with oligopeptide mixture, group III (n=40) - total parenteral nutrition (TPN). The subgroups were also isolated depending on medication: A - Octreotide, B - Quamatel, C - Octreotide + Quamatel. Pancreatic secretion was evaluated by using of course of disease, instrumental methods, APUD-system hormone levels (secretin, cholecystokinin, somatostatin, vasointestinal peptide). RESULTS: ETF was followed by pancreas enlargement despite ongoing therapy, while TPN led to gradual reduction of pancreatic size up to normal values. α-amylase level progressively decreased in all groups, however in patients who underwent ETF (I and II) mean values of the enzyme were significantly higher compared with TPN (group III). Secretin, cholecystokinin and vasointestinal peptide were increasing in most cases, while the level of somatostatin was below normal in all groups. CONCLUSION: Enteral tube feeding (balanced and oligopeptide mixtures) contributes to pancreatic secretion compared with TPN, but this negative impact is eliminated by antisecretory therapy. Dual medication (Octreotide + Quamatel) is more preferable than monotherapy (Octreotide or Quamatel).
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180129
[Lr] Last revision date:180129
[St] Status:In-Data-Review
[do] DOI:10.17116/hirurgia2018114-20

  9 / 9139 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29230485
[Au] Autor:Hollenbach M; Hoffmeister A; Rosendahl J; Mössner J
[Ad] Address:Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig AöR, Liebigstraße 20, 04103, Leipzig, Deutschland. marcus.hollenbach@web.de.
[Ti] Title:Stellenwert der Funktionsdiagnostik in der Gastroenterologie. [Importance of functional diagnostics in gastroenterology].
[So] Source:Internist (Berl);59(1):25-37, 2018 Jan.
[Is] ISSN:1432-1289
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:In this review article important and frequently used investigation methods for gastrointestinal functional diagnostics are presented. Some other rarely used special investigations are also explained. The hydrogen breath test is simple to carry out, ubiquitously available and enables the detection of lactose, fructose and sorbitol malabsorption. Furthermore, by the application of glucose, the test can be carried out when there is a suspicion of abnormal intestinal bacterial colonization and using lactulose for measuring small intestinal transit time. The C urea breath test is applied for non-invasive determination of Helicobacter pylori infections and assessment of gastrointestinal transit time, liver and exocrine pancreas functions. The secretin cholecystokinin test was the gold standard for the detection of exocrine pancreas insufficiency. However, measurement of pancreatic elastase in stool is less invasive but also less sensitive. Scintigraphy and capsule investigations with pH and temperature probes constitute important methods for determination of gastric emptying, intestinal and colon transit times. For evaluation of constipation panoramic abdominal images are taken after intake of radiologically opaque markers (Hinton test). For the diagnosis of functional esophageal diseases manometry is indispensable. In addition, manometry is only occasionally used for diagnosing a dysfunction of the sphincter of Oddi, due to the danger of inducing pancreatitis. A 24 h pH-metry is applied for the detection of non-erosive gastroesophageal reflux disease and, if necessary, with impedance measurements. Recent investigation procedures, e. g. specific MRI sequences, sonographic determination of gall bladder ejection fraction, analysis of gastric accomodation or real-time lumen imaging, require further evaluation prior to clinical application.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180119
[Lr] Last revision date:180119
[St] Status:In-Data-Review
[do] DOI:10.1007/s00108-017-0359-0

  10 / 9139 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29302785
[Au] Autor:Schawkat K; Ith M; Christe A; Kühn W; Chittazhathu Y; Bains L; Runge VM; Heverhagen JT
[Ad] Address:Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland. k_schawkat@hotmail.com.
[Ti] Title:Dynamic non-invasive ASL perfusion imaging of a normal pancreas with secretin augmented MR imaging.
[So] Source:Eur Radiol;, 2018 Jan 04.
[Is] ISSN:1432-1084
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To investigate prospectively the repeatability of pancreatic perfusion measurements using arterial spin labelling (ASL) and to determine the increase in perfusion due to secretin stimulation. MATERIAL AND METHODS: An (FAIR)-TrueFISP ASL sequence was applied to determine the perfusion of the pancreatic head in a 3T MRI scanner. Ten healthy volunteers (four men, six women: mean age 28.5 ± 4.6 years; age range 25-40 years) were investigated twice within 1 week. The inter-individual variability was calculated using the standard deviation. Intra-individual agreement between the first and second scan was estimated using the Pearson correlation coefficient. A paired Wilcoxon rank-sum test was used to compare perfusion at baseline (BL) and during secretin stimulation. RESULTS: The mean BL perfusion of the pancreatic head was 285 ± 96 mL/100 g/min with an intra-individual correlation coefficient of 0.67 (strong) for repeated measurements. Secretin stimulation led to a significant increase (by 81%) in perfusion of the pancreatic head to 486 ±156 mL/100 g/min (p=0.002) with an intra-individual correlation of 0.29 (weak). A return to BL values was observed after 239 ± 92 s with a moderate intra-individual correlation coefficient of 0.42 for repeat measurements. CONCLUSION: Dynamic non-invasive ASL imaging of the pancreas permitted quantification of pancreatic perfusion in a clinically applicable setting. KEY POINTS: • ASL imaging of the pancreas permitted quantification of pancreatic perfusion • Secretin stimulation led to a significant increase in pancreatic perfusion • The intra-individual correlation coefficient for baseline perfusion was strong for repeated measurements.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180105
[Lr] Last revision date:180105
[St] Status:Publisher
[do] DOI:10.1007/s00330-017-5227-8


page 1 of 914 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information