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[PMID]: 29524422
[Au] Autor:Pan G; Hao H; Liu J
[Ad] Address:Department of Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
[Ti] Title:Induction of hepatocytes-derived insulin-producing cells using small molecules and identification of microRNA profiles during this procedure.
[So] Source:Biochem Biophys Res Commun;, 2018 Mar 07.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The transplantation of insulin-producing cells (IPCs) or pancreatic progenitor cells is a theoretical therapy for diabetes with insulin insufficiency. Isolated hepatocytes from newborn rats (within 24 h after birth) were progressively induced into IPCs using 5-aza-2'-deoxycytidine, Trichostatin A, retinoic acid, insulin-transferrin-selenium, and nicotinamide. We transplanted Pdx1+ pancreatic progenitors into STZ-induced diabetic mice and found the decreased blood glucose and increased insulin level in comparison with diabetic model. The dynamic expression profiles of microRNAs (miRNAs) were identified using microarray. We found 67 miRNAs were decreasingly expressed; 52 miRNAs were increasingly expressed; 27 miRNAs were specially inhibited in Stage 1 cells (multipotent progenitor cells); and 58 miRNAs were specially inhibited in Pdx1+ cells (Stage 2). Further analysis showed these miRNAs' targets were associated with genetic recombination, stem cell pluripotency maintenance, cellular structure reorganization and insulin secretion. Enrichment analysis using KEGG pathway showed the differentiation of IPCs from hepatocytes was massively more likely not mediated by canonical Wnt/ß-catenin signaling. In addition, the BMP/Smad signaling was involved in this progression. We found the dysregulated miRNAs profiles were inconsistent with cell phenotypes and might be responsible for small molecule-mediated cell differentiation during IPCs induction.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 31007 MEDLINE  
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[PMID]: 29510219
[Au] Autor:Copat C; Grasso A; Fiore M; Cristaldi A; Zuccarello P; Signorelli SS; Conti GO; Ferrante M
[Ad] Address:Department of Medical, Surgery Sciences and Advanced Technologies, G. F. Ingrassia, University of Catania, Via Santa Sofia 87, 95123, Catania, Italy. Electronic address: ccopat@unict.it.
[Ti] Title:Trace elements in seafood from the Mediterranean sea: An exposure risk assessment.
[So] Source:Food Chem Toxicol;115:13-19, 2018 Mar 03.
[Is] ISSN:1873-6351
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Fish and shellfish belonging to five different species among pelagic, benthonic and molluscs, were collected from the Gulf of Catania in 2017 to evaluate arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), manganese (Mn), nickel (Ni), selenium (Se) vanadium (V) and zinc (Zn). Risk of developing chronic systemic effects derived from seafood consumption was evaluated with the Target Hazard Quotient (THQ) and compared with the results obtained from the same area and the species, collected in 2012. Hg, Cd and Pb concentrations were found below the limits set by European Community for human consumption in all the analysed species. The total risk is reduced from 1.1 to 0.49, and this result is strongly associated with the lower bioaccumulations levels found for Hg, Mn, Se and V. Others metals such as As, Pb, Ni and Zn bioaccumulation levels remain approximately the same, conversely, it is revealed a slight increase of Cd and Cr. Overall, the present study show a positive picture of the studied area, the Gulf of Catania, highlighting not only a decreased metal availability of the study area, but, above all, a decreased risk to develop chronic systemic effects derived from consumption of local seafood.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 31007 MEDLINE  
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[PMID]: 29496617
[Au] Autor:Tsitsipatis D; Gopal K; Steinbrenner H; Klotz LO
[Ad] Address:Institute of Nutrition, Department of Nutrigenomics, Friedrich-Schiller-Universität Jena, D-07743 Jena, Germany.
[Ti] Title:FOXO1 cysteine-612 mediates stimulatory effects of the coregulators CBP and PGC1α on FOXO1 basal transcriptional activity.
[So] Source:Free Radic Biol Med;118:98-107, 2018 Mar 02.
[Is] ISSN:1873-4596
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hepatic production and release of metabolites, nutrients and micronutrient transporters is tightly regulated at the level of gene expression. In this regard, transcription factor FOXO1 modulates the expression of genes such as G6PC and SELENOP, encoding the catalytic subunit of glucose 6-phosphatase and the plasma selenium transporter selenoprotein P, respectively. Here, we analyzed the role of cysteine residues in FOXO1 in controlling its activity with respect to regulation of G6PC and SELENOP in HepG2 human hepatoma cells. None of the seven FOXO1 cysteines affected FOXO1 binding to DNA or its basal subcellular distribution. Whereas overexpression of wildtype FOXO1 caused a strong induction of both G6PC and SELENOP promoter activities and mRNA levels, the induction was lowered by approx. 50% if cysteine-deficient FOXO1 was overexpressed instead. Only the most C-terminal of the seven FOXO1 cysteines, Cys612, was required and sufficient to ensure full FOXO1 transactivation activity. Coexpression of FOXO1 coregulators, CBP or PGC1α, had a strong synergistic effect in stimulating G6PC promoter activity and expression, fully relying on the presence of FOXO1 Cys612. Similarly, a synergistic effect of FOXO1 and CBP was observed for SELENOP. In contrast, stimulation of SELENOP by PGC1α was independent of FOXO1-Cys612, due to the close proximity of a hepatocyte nuclear factor-4α binding site to the FOXO1 binding site within the SELENOP promoter, as demonstrated using mutant SELENOP promoter constructs. In summary, full basal FOXO1 transactivation activity relies on Cys612, which mediates synergistic effects of coregulators, CBP or PGC1α, on FOXO1 transcriptional activity. The extent of Cys612 contribution depends on the promoter context of FOXO1 target genes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 31007 MEDLINE  
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[PMID]: 29471004
[Au] Autor:Chhabra G; Singh CK; Ndiaye MA; Fedorowicz S; Molot A; Ahmad N
[Ad] Address:Department of Dermatology, University of Wisconsin, Madison, WI, USA.
[Ti] Title:Prostate cancer chemoprevention by natural agents: Clinical evidence and potential implications.
[So] Source:Cancer Lett;422:9-18, 2018 Feb 20.
[Is] ISSN:1872-7980
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Prostate cancer (PCa) is the most common non-skin cancer and the second leading cause of cancer-related deaths in American men. Due to its long latency period, PCa is considered as an ideal cancer type for chemopreventive interventions. Chemopreventive agents include various natural or synthetic agents that prevent or delay cancer development, progression and/or recurrence. Pre-clinical studies suggest that many natural products and dietary agents have chemopreventive properties. However, a limited number of these agents have been tested in clinical trials, with varying success. In this review, we have discussed the available clinical studies regarding the efficacy of natural chemopreventive agents against PCa, including tea polyphenols, selenium, soy proteins, vitamins and resveratrol. We have also provided a discussion on the clinical challenges and opportunities for the potential use of chemopreventive agents against PCa. Based on available literature, it appears that the variable outcomes of the chemopreventive clinical studies necessitate a need for additional studies with more rigorous designs and methodical interpretations in order to measure the potential of the natural agents against PCa.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  5 / 31007 MEDLINE  
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[PMID]: 29524195
[Au] Autor:Gao J; Nie W; Wang F; Guo Y
[Ad] Address:State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.
[Ti] Title:Maternal Selenium Supplementation Enhanced Skeletal Muscle Development Through Increasing Protein Synthesis and SelW mRNA Levels of their Offspring.
[So] Source:Biol Trace Elem Res;, 2018 Mar 09.
[Is] ISSN:1559-0720
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The present study aimed to investigate the influence of maternal selenium supplementation on the skeletal muscle development of the offspring. A total of 720 Ross 308 broiler breeders at 24-week-old were allocated into 3 treatments with 6 replicates of 40 hens each and fed with 0 mg/kg-(group Se/C), 0.5 mg/kg organic-(group Se/O), and 0.5 mg/kg inorganic-(group Se/I) selenium, respectively for 8 weeks. The male offspring from each nutritional treatment were divided and housed into 8 cages of 12 birds each and fed with a commercial diet supplemented with selenium from Na SeO at 0.15 mg/kg. Results showed that Se/O group had the highest selenium deposition (P < 0.05) in the egg yolk and albumen. Furthermore, maternal selenium supplementation promoted breast muscle yield; increased serum insulin and IGF-I concentration; upregulated AKT, mammalian target of rapamycin (mTOR), P70S6K, Myf5, MyoD, MyoG, and SelW mRNA levels; and improved the phosphorylation of AKT at Serine 473 residue, mTOR at Serine 2448 residue, and FOXO at Serine 256 residue in skeletal muscles of the offspring. In contrast, the hens' diet supplemented with selenium could result in reduction of uric acid level in serum and downregulation of Atrogin-1 and MuRF1 mRNA levels in the skeletal muscle of the offspring. Additionally, no significant effect on the skeletal muscle development post-hatch was observed between organic and inorganic selenium supplementation. In conclusion, maternal organic selenium supplementation improved selenium deposition in egg; however, no significant effect has been detected on the breast muscle development of the offspring of broiler breeder compared with inorganic selenium supplementation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s12011-018-1288-z

  6 / 31007 MEDLINE  
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[PMID]: 29524194
[Au] Autor:Zheng SF; Bao RK; Zhang QJ; Wang SC; Lin HJ
[Ad] Address:College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, P. R. China.
[Ti] Title:Endogenous Hydrogen Sulfide Promotes Apoptosis via Mitochondrial Pathways in the Livers of Broilers with Selenium Deficiency Exudative Diathesis Disease.
[So] Source:Biol Trace Elem Res;, 2018 Mar 09.
[Is] ISSN:1559-0720
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hydrogen sulfide (H S), an endogenous gasotransmitter, plays an important role in apoptosis. Exudative diathesis (ED) disease is associated with dietary selenium (Se) deficiency in broilers. The liver is one of the target organs of Se deficiency; however, little is known about the effect of H S on apoptosis via mitochondrial pathways in the livers of broilers with ED disease. In the present study, we aimed to investigate the correlation between endogenous H S and mitochondrial-mediated apoptosis in the livers of broilers with ED disease, as induced by Se deficiency. One hundred twenty healthy, 1-day-old broilers were randomly assigned to one of two groups (60 each) based on diet: Basal diet (control group, 0.2 mg/kg Se) or a low-Se diet (-Se group, 0.033 mg/kg Se). At day 20, 15 broilers of a similar weight were sacrificed from the control group, while the same number of broilers were euthanatized from the -Se group when displaying typical symptoms of ED between days 18 and 25. The livers were collected, and apoptosis was measured using a TUNEL assay. Additionally, H S concentration, the expression of H S synthases of cystathionine γ-lyase (CSE), cystathionine ß-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST), as well as mitochondrial apoptosis-related genes of Bcl-2, Bax, Bak, Cyt-C, Caspase-9, Caspase-3, and p53, were examined in livers. The results indicated that Se deficiency could induce apoptosis in the livers of broilers. Swelling, fractures, and vacuolization were visible in the mitochondrial cristae in the livers of the -Se group. The expression of H S synthase-related genes and H S concentration was significantly enhanced (P < 0.05) in the livers of the -Se group compared to controls. Moreover, a low-Se diet downregulated (P < 0.05) the level of Bcl-2 and upregulated (P < 0.05) the levels of Bax, Bak, Cyt-C, Caspase-9, Caspase-3, and p53. These results suggest that an H S increase in the livers of ED broilers, which was induced by Se deficiency, is related to apoptosis mediated by mitochondrial pathways.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s12011-018-1292-3

  7 / 31007 MEDLINE  
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[PMID]: 29522794
[Au] Autor:Angeli JPF; Conrad M
[Ad] Address:Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany. Electronic address: pedro.angeli@virchow.uni-wuerzburg.de.
[Ti] Title:Selenium and GPX4, a vital symbiosis.
[So] Source:Free Radic Biol Med;, 2018 Mar 06.
[Is] ISSN:1873-4596
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Selenium has transitioned from an environmental poison and carcinogen to an essential micronutrient associated with a broad array of health promoting effects. These beneficial effects are now accepted to be linked to its incorporation into selenoproteins, a family of rare proteins utilizing a specialized translation machinery to integrate selenium in the form of selenocysteine. Despite this recognised role, much less is known regarding the actual role of selenium in these proteins. Here, we will provide the reader with an overview of the essential role of specific selenoproteins and their link to pathology based on mouse studies and relevant mutations discovered in humans. Additionally, we will cover recent insights linking a non-interchangeable role for selenium in glutathione peroxidase 4 and its function in suppressing ferroptosis. This critical dependency ultimately generates a strong reliance on metabolic pathways that regulate selenium metabolism and its incorporation into proteins, such as the mevalonate pathway.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  8 / 31007 MEDLINE  
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[PMID]: 29451338
[Au] Autor:Payne NC; Barber DR; Ruggles EL; Hondal RJ
[Ad] Address:Department of Biochemistry, University of Vermont, College of Medicine, Burlington, Vermont, 05405.
[Ti] Title:Can dimedone be used to study selenoproteins? An investigation into the reactivity of dimedone toward oxidized forms of selenocysteine.
[So] Source:Protein Sci;, 2018 Feb 16.
[Is] ISSN:1469-896X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Dimedone is a widely used reagent to assess the redox state of cysteine-containing proteins as it will alkylate sulfenic acid residues, but not sulfinic acid residues. While it has been reported that dimedone can label selenenic acid residues in selenoproteins, we investigated the stability, and reversibility of this label in a model peptide system. We also wondered whether dimedone could be used to detect seleninic acid residues. We used benzenesulfinic acid, benzeneseleninic acid, and model selenocysteine-containing peptides to investigate possible reactions with dimedone. These peptides were incubated with H O in the presence of dimedone and then the reactions were followed by liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS). The native peptide, H-PTVTGCUG-OH (corresponding to the native amino acid sequence of the C-terminus of mammalian thioredoxin reductase), could not be alkylated by dimedone, but could be carboxymethylated with iodoacetic acid. However the "mutant peptide," H-PTVTGAUG-OH, could be labeled with dimedone at low concentrations of H O , but the reaction was reversible by addition of thiol. Due to the reversible nature of this alkylation, we conclude that dimedone is not a good reagent for detecting selenenic acids in selenoproteins. At high concentrations of H O , selenium was eliminated from the peptide and a dimeric form of dimedone could be detected using LCMS and H NMR. The dimeric dimedone product forms as a result of a seleno-Pummerer reaction with Sec-seleninic acid. Overall our results show that the reaction of dimedone with oxidized cysteine residues is quite different from the same reaction with oxidized selenocysteine residues.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1002/pro.3390

  9 / 31007 MEDLINE  
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[PMID]: 29446273
[Au] Autor:Boyarskaya LA; Vil'ms EA; Turchaninov DV; Bogdashin IV; Erofeev YV
[Ti] Title:[Hygienic substantiation of application of functional dairy products in the prevention of macro- and micronutrient deficiency].
[So] Source:Gig Sanit;95(11):1095-9, 2016.
[Is] ISSN:0016-9900
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Based on the study of actual nutrition and availability of macroelements there was found that adult population of the city of Omsk was established to refer to the group at risk for the development of micronutrient deficiency associated with low content of a set of essential elements (copper, zinc, calcium, selenium) in the ration, being prior for correction.There was executed the hygienic substantiation developed the fermented acid milk bioproduct of a functional purpose "Bifidin" enriched with micronutrients, prior for the population of the Omsk region. Introduction of this bio-product into the ration allows to effectively correct disorders of the mineral status, that was manifested in a decline in the proportion of patients with insufficiency of calcium (from 37.9 to 24.1%; p = 0.013), copper (from 51.7 to 25.9%; p = 0.004), selenium (from 96.6 to 84.5%; p = 0.026), zinc (from 58.6 to 48.3% of the subjects; p = 0.264). Upon the completion of the prophylactic course (intake "Bifidin" of 200 ml for 60 days), there was noted the gain in the concentration in hair: calcium (by 24.4%; p=0.441), zinc (by 8.0%; p=0.0008), copper (by 8.8%; p < 0.001), selenium (by 41.5%; p < 0.001). There was established the efficacy of the use of bio-product "Bifidin" enriched with micronutrients for the improvement of the structure of nutrition and element status of the adult population of the city of Omsk. There was justified the extensive use of dairy products enriched with micronutrients both for the reduction of the prevalence of microelementoses and the improvement of the nutritional status.
[Mh] MeSH terms primary: Dairy Products
Deficiency Diseases
Dietary Supplements
Feeding Behavior
Micronutrients/analysis
Trace Elements/analysis
[Mh] MeSH terms secundary: Adult
Deficiency Diseases/diagnosis
Deficiency Diseases/epidemiology
Deficiency Diseases/prevention & control
Female
Hair/chemistry
Humans
Male
Nutritional Requirements/physiology
Nutritional Status
Preventive Health Services/methods
Siberia/epidemiology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Micronutrients); 0 (Trace Elements)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180216
[St] Status:MEDLINE

  10 / 31007 MEDLINE  
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[PMID]: 28837875
[Au] Autor:Molnár Á; Feigl G; Trifán V; Ördög A; Szollosi R; Erdei L; Kolbert Z
[Ad] Address:Department of Plant Biology, University of Szeged, Közép fasor 52, H-6726 Szeged, Hungary. Electronic address: molnara@bio.u-szeged.hu.
[Ti] Title:The intensity of tyrosine nitration is associated with selenite and selenate toxicity in Brassica juncea L.
[So] Source:Ecotoxicol Environ Saf;147:93-101, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Selenium phytotoxicity involves processes like reactive nitrogen species overproduction and nitrosative protein modifications. This study evaluates the toxicity of two selenium forms (selenite and selenate at 0µM, 20µM, 50µM and 100µM concentrations) and its correlation with protein tyrosine nitration in the organs of hydroponically grown Indian mustard (Brassica juncea L.). Selenate treatment resulted in large selenium accumulation in both Brassica organs, while selenite showed slight root-to-shoot translocation resulting in a much lower selenium accumulation in the shoot. Shoot and root growth inhibition and cell viability loss revealed that Brassica tolerates selenate better than selenite. Results also show that relative high amounts of selenium are able to accumulate in Brassica leaves without obvious visible symptoms such as chlorosis or necrosis. The more severe phytotoxicity of selenite was accompanied by more intense protein tyrosine nitration as well as alterations in nitration pattern suggesting a correlation between the degree of Se forms-induced toxicities and nitroproteome size, composition in Brassica organs. These results imply the possibility of considering protein tyrosine nitration as novel biomarker of selenium phytotoxicity, which could help the evaluation of asymptomatic selenium stress of plants.
[Mh] MeSH terms primary: Mustard Plant/drug effects
Nitro Compounds/metabolism
Reactive Nitrogen Species/metabolism
Selenic Acid/toxicity
Selenious Acid/toxicity
Tyrosine/metabolism
[Mh] MeSH terms secundary: Biological Transport
Dose-Response Relationship, Drug
Hydroponics
Mustard Plant/metabolism
Selenic Acid/metabolism
Selenious Acid/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Nitro Compounds); 0 (Reactive Nitrogen Species); 42HK56048U (Tyrosine); F6A27P4Q4R (Selenious Acid); HV0Y51NC4J (Selenic Acid)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:170825
[St] Status:MEDLINE


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