Database : MEDLINE
Search on : serositis [Words]
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[PMID]: 29520672
[Au] Autor:Xu SZ; Yan Liang; Li XP; Li XM; Shuai ZW; Leng RX; Pan HF; Ye DQ
[Ad] Address:Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
[Ti] Title:Features associated with pulmonary arterial hypertension in Chinese hospitalized systemic lupus erythematosus patients.
[So] Source:Clin Rheumatol;, 2018 Mar 08.
[Is] ISSN:1434-9949
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Pulmonary arterial hypertension (PAH) is an increasingly recognized complication of systemic lupus erythematosus (SLE). This study aims to estimate the point prevalence of PAH and identify risk factors for PAH in a large cohort of hospitalized SLE patients. We have collected the medical records of patients hospitalized with SLE at the First Affiliated Hospital of Anhui Medical University and Anhui Provincial Hospital. Resting transthoracic echocardiography (TTE) was used to estimate pulmonary artery pressure (PAP) and PAH was defined as systolic PAP (PASP) > 30 mmHg. Patients with other connective tissue diseases, aPL syndrome, left heart disease, valvular heart disease, congenital heart disease, HIV, and portal hypertension were excluded because of diseases affecting the PAP. We assessed potential risk factors for PAH such as thrombogenic factors, SLE clinical manifestations, laboratory abnormalities and disease activity. Ninety-five were diagnosed with PAH of 1639 patients with SLE. The presence of high fibrinogen, serositis, and thrombocytopenia were significantly higher in patients with PAH than in those without PAH (all P < 0.05). Multivariate logistic regression found the associations between high fibrinogen (OR = 1.629), serositis (OR = 2.866), and thrombocytopenia (OR = 1.825) with PAH. The point prevalence of PAH was 5.8% in our cohort of patients with SLE. The significant association of high fibrinogen, serositis, and thrombocytopenia with PAH suggested that hypercoagulable state, organ damage, and hematological abnormality may all contribute to the development of PAH in SLE. This is important, as it is treatable.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1007/s10067-018-4056-8

  2 / 1111 MEDLINE  
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[PMID]: 29506437
[Au] Autor:Farooq Sheikh AS; Marks J; Hopkinson N
[Ad] Address:1 Rheumatology Registrar, Department of Rheumatology, Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, UK.
[Ti] Title:Adult-onset Still's disease with prominent polyserositis.
[So] Source:Scott Med J;:36933018760763, 2018 Jan 01.
[Is] ISSN:0036-9330
[Cp] Country of publication:Scotland
[La] Language:eng
[Ab] Abstract:Adult-onset Still's disease is a systemic autoinflammatory disease the presentation of which can often mimic infection. As a consequence, there is often a delay in diagnosis. Serositis is a recognised but less common clinical feature that can result in complications including cardiac tamponade and constrictive pericarditis. We describe a case of adult-onset Still's disease without the hallmark rash or significant arthritis, presenting with polyserositis that showed a good response to initial steroid treatment and sustained remission with anakinra. An elevated procalcitonin level was due to active adult-onset Still's disease, not bacterial infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1177/0036933018760763

  3 / 1111 MEDLINE  
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[PMID]: 29488577
[Au] Autor:Barrera O M; Barrera M R; de la Rivera V M; Vela U J; Mönckeberg F G
[Ad] Address:Clínica Universidad de los Andes, Santiago, Chile.
[Ti] Title:Enteritis lúpica como manifestación inicial de lupus eritematoso sistémico. Caso clínico. [Lupus enteritis as initial manifestation of systemic lupus erythematosus. Report of one case].
[So] Source:Rev Med Chil;145(10):1349-1352, 2017 Oct.
[Is] ISSN:0717-6163
[Cp] Country of publication:Chile
[La] Language:spa
[Ab] Abstract:Although gastrointestinal symptoms are not rare in Systemic lupus erythematosus, enteritis is an atypical manifestation of the disease. We report a 54 year-old woman who presented acute symptoms of diarrhea, fever and abdominal pain, receiving empiric antibiotic therapy for bacterial enteritis with no response. Computed tomography showed diffuse small intestine inflammation and serositis. Antinuclear antibodies, anti-Ro and anti-La were positive on blood tests. A lupic enteropathy was diagnosed and steroid treatment was initiated, with subsequent clinical improvement.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Process

  4 / 1111 MEDLINE  
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[PMID]: 29461752
[Au] Autor:Carlomagno R; Hentgen V
[Ad] Address:Unité romande d'immuno-rhumatologie pédiatrique, CHUV, 1011 Lausanne et HUG, 1211 Genève 14.
[Ti] Title:Fièvres récurrentes auto-inflammatoires : la bonne démarche diagnostique. [Recurrent auto-inflammatory fevers : a practical diagnostic flow chart].
[So] Source:Rev Med Suisse;14(594):378-383, 2018 Feb 14.
[Is] ISSN:1660-9379
[Cp] Country of publication:Switzerland
[La] Language:fre
[Ab] Abstract:Recurrent autoinflammatory fever syndromes are characterized by an abnormal activation of the innate immune system pathways, leading to inappropriate systemic inflammation responsible for clinical symptoms. The diagnosis of these conditions is difficult because of their low prevalence, but also because of their nonspecific clinical signs. The presence of clinical inflammatory signs such as fever associated to serositis (arthritis, peritonitis …) or recurrent cutaneous manifestations and elevated acute phase reactants should help the clinician to make the correct diagnosis. The purpose of this article is to provide a practical management flow chart for children with a suspected autoinflammatory recurrent fever syndrome.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:In-Data-Review

  5 / 1111 MEDLINE  
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[PMID]: 29460702
[Au] Autor:Abdel-Nabi HH; Abdel-Noor RA
[Ad] Address:1 Pediatric Department, Tanta University, Tanta, Egypt.
[Ti] Title:Comparison between disease onset patterns of Egyptian juvenile and adult systemic lupus erythematosus (single centre experience).
[So] Source:Lupus;:961203318760208, 2018 Jan 01.
[Is] ISSN:1477-0962
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease that occurs worldwide in both children and adults, with different disease manifestations, activity and severity between them. Objectives To analyse the difference in disease onset patterns and activity in Egyptian children and adults with SLE. Methods A retrospective cohort study conducted on 298 Egyptian SLE patients, 215 adults (a-SLE) (>18 years) and 83 children (j-SLE) (≤18 years). Disease onset, clinical manifestations and laboratory investigations were recorded. The systemic lupus erythematosus disease activity index (SLEDAI) was used to assess disease onset activity; renal biopsy was performed for all cases affected with renal symptoms. Results A total of 215 a-SLE (F/M: 14.4/1), mean age 29.65 ± 10.235 years, and 83 j-SLE (F/M: 5.4/1), mean age at diagnosis 12.63 ± 3.112 years. The most frequent initial a-SLE symptoms were constitutional (88.8%), mucocutaneous (71.2%), haematological (64.2%), articular (62.3%), renal (43.7%), vascular (15.3%), serositis (14.4%) and finally central nervous system (11.6%). There were no significant differences between a-SLE and j-SLE with regard to constitutional, mucocutaneous, renal, vascular and serositis manifestations, which were 92.8%, 74.7%, 53%, 16.9% and 10.8%, respectively, but the j-SLE haematological (88%) and central nervous system (30.1%) manifestations were significantly higher than a-SLE and articular manifestations were significantly lower in j-SLE (14.5%) than a-SLE. Antinuclear antibodies were positive for 95.3% of a-SLE and 97.6% of j-SLE. Anti-dsDNA was positive for 84.7% a-SLE and was significantly higher in j-SLE (92.8%). The SLEDAI score was 12.23 ± 4.966 in a-SLE and was significantly higher in j-SLE (27.13 ± 19.968). International Society of Nephrology lupus nephritis classes III and IV (42.4%) were the commonest findings in a-SLE; however, classes I and III (57.9%) were the commonest in j-SLE. Conclusions SLE had a wide variety of clinical and immunological manifestations, with some similarity and differences between a-SLE and j-SLE; juvenile onset lupus had a higher SLEDAI with more aggressive initial manifestations than a-SLE.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher
[do] DOI:10.1177/0961203318760208

  6 / 1111 MEDLINE  
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[PMID]: 29460700
[Au] Autor:Fedrigo A; Dos Santos TAFG; Nisihara R; Skare T
[Ad] Address:1 Rheumatology Service, Evangelical University Hospital of Curitiba, Curitiba, Brazil.
[Ti] Title:The lupus patient with positive rheumatoid factor.
[So] Source:Lupus;:961203318759607, 2018 Jan 01.
[Is] ISSN:1477-0962
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study of 467 SLE patients seen at a single rheumatology unit was conducted. Epidemiological data (age, gender, age at disease onset, ethnic background and tobacco use), clinical data (malar rash, photosensitivity, oral ulcers, discoid lesions, serositis, glomerulonephritis, convulsions, psychosis, hemolytic anemia, leukopenia, lymphocytopenia, arthritis and hypothyroidism) and serological profile (anti-dsDNA, anti-Ro/SS-A, anti-La/SS-B, anti-RNP, anti-Sm, IgG aCL, IgM aCL, lupus anticoagulant, direct Coombs and RF) were collected. Patients with positive and negative RF were compared. Results RF was found in 24.9% of the sample. In univariate analysis, RF was positively associated with butterfly rash ( p = 0.04), anti-Ro ( p = 0.03), anti-Sm antibodies ( p = 0.01) and hypothyroidism ( p = 0.01) and negatively associated with glomerulonephritis ( p = 0.003). Logistic regression showed that only glomerulonephritis ( p = 0.03; OR = 0.45; 95% CI = 0.21-0.93) and anti-Ro ( p = 0.009; OR = 2.3; 95% CI = 1.24-4.57) were independent associations. Conclusion In our sample RF was associated with protection from glomerulonephritis and with higher prevalence of anti-Ro antibodies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher
[do] DOI:10.1177/0961203318759607

  7 / 1111 MEDLINE  
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[PMID]: 29299823
[Au] Autor:Peng W; Tang Y; Tan L; Qin W
[Ad] Address:Department of Nephrology, West China Hospital, Sichuan University, 37th Guoxuexiang Road, Chengdu, 610041, China.
[Ti] Title:Clinicopathological study of male and female patients with lupus nephritis: a retrospective study.
[So] Source:Int Urol Nephrol;50(2):313-320, 2018 Feb.
[Is] ISSN:1573-2584
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:PURPOSE: The aim of this study was to assess the impact of sex on long-term outcomes in patients with lupus nephritis (LN). METHODS: Data of patients were collected at a single tertiary hospital from June 2010 to June 2016. Clinicopathological features and treatment responses of LN patients with different genders were compared. The primary endpoint was serum creatinine level doubled, GFR < 15 mL/min, initiation of renal replacement treatment or death. The secondary endpoint was complete remission or partial remission. RESULTS: In total, 101 male patients and 579 females were included. The follow-up time was 49.7 ± 15.2 months. In clinical data, photosensitivity and mouth ulcers were more common in the female patients, while males had more serositis and vasculitis. In laboratory data, males had higher values of blood pressure, hemoglobin, urine protein, serum creatinine and a lower level of serum albumin. Activity index and endocapillary hypercellularity scores in the male group were significantly increased. No sex disparity was identified across secondary endpoints in all cases, despite a lower ratio of CR in males. As for the long-term survival, no statistic difference between the two groups was observed. In a further multivariate Cox hazard analysis, male gender was not identified as an independent risk factor for poor outcomes. CONCLUSION: Despite a greater disease activity and more severe organ damage in males with LN, we did not observe any significant gender disparity in long-term survival. Large multicenter collaborative efforts are necessary.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180219
[Lr] Last revision date:180219
[St] Status:In-Process
[do] DOI:10.1007/s11255-017-1780-y

  8 / 1111 MEDLINE  
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[PMID]: 29450637
[Au] Autor:Yazilitas F; Aydog Ö; Özlü SG; Çakici EK; Güngör T; Eroglu FK; Gür G; Bülbül M
[Ad] Address:Pediatric Nephrology Department, Ankara Dr. Sami Ulus Maternity and Children Hospital, Babur Caddesi No. 44, Altindag, 06080, Ankara, Turkey. fmeryemesra@yahoo.com.
[Ti] Title:Canakinumab treatment in children with familial Mediterranean fever: report from a single center.
[So] Source:Rheumatol Int;, 2018 Feb 15.
[Is] ISSN:1437-160X
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Familial Mediterranean fever (FMF), the most common hereditary autoinflammatory disorder is characterized by recurrent episodes of fever, serositis, arthritis. The major long-term result is amyloidosis. Colchicine remains the principle of the treatment; it not only prevents the acute attacks but also prevents the long-term complications such as amyloidosis; 5-10% of the patients are unresponsive to treatment. Recently new therapeutic options as anti-interleukin 1 agents are successfully used for the patients who do not respond to colchicine treatment. In this study, we retrospectively evaluated 11 pediatric colchicine-resistant FMF patients who were treated with canakinumab. Three of the patients had amyloidosis and two had uveitis. Based on our results, we suggest that canakinumab may be a safe and effective therapy in patients who are resistant to colchicine and even in the patients with amyloidosis. We also suggest that canakinumab might be a safe option for the patients with uveitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[St] Status:Publisher
[do] DOI:10.1007/s00296-018-3993-5

  9 / 1111 MEDLINE  
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[PMID]: 29442258
[Au] Autor:Hortu HO; Karaca E; Sozeri B; Gulez N; Makay B; Gunduz C; Atik T; Tekin IM; Unsal SE; Ozgur C
[Ad] Address:Faculty of Medicine, Department of Pediatrics, Ege University, Izmir, Turkey.
[Ti] Title:Evaluation of the effects of miRNAs in familial Mediterranean fever.
[So] Source:Clin Rheumatol;, 2018 Feb 13.
[Is] ISSN:1434-9949
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Familial Mediterranean fever (FMF) is an inherited autoinflammatory disorder that can result in attacks with accompanying recurrent episodes of fever, serositis, and skin rash. MiRNAs are demonstrated to be associated with a number of other diseases; however, no comprehensive study has revealed its association with FMF disease. The aim is to investigate the role of microRNAs in FMF. We included 51 patients with genetically diagnosed FMF who had clinical symptoms and 49 healthy volunteers. Fifteen miRNAs that were found to be associated with autoinflammatory diseases and have a part in immune response were evaluated. The expression levels of 11 miRNAs (miR-125a, miR-132, miR-146a, miR-155, miR-15a, miR-16, miR-181a, miR-21, miR-223, miR-26a, and miR-34a) in the patient group were significantly low, compared with the control group (p < 0.05). The patient group was analyzed and compared within itself, and the expression levels of 5 miRNAs (miR-132, miR-15a, miR-181a, miR-23b, miR-26a) in the patients who took colchicine seemed to have increased and levels of 5 miRNAs (miR-146a, miR-15a, miR-16, miR-26a, miR-34a) in the patients who took colchicine were significantly lower (p < 0.05). Furthermore, the attack patients were compared with the control group, and their expression levels of 4 miRNAs (miR-132, miR-15a, miR-21, miR-34a) were significantly lower (p < 0.05). Levels of 9 miRNAs (miR-132, miR-146a, miR-15a, miR-16, miR-181a, miR-21, miR-223, miR-26a, miR-34a) in non-attack patients decreased significantly (p < 0.05). Our study demonstrates that miRNAs could be effective in the pathogenesis of FMF.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:Publisher
[do] DOI:10.1007/s10067-017-3914-0

  10 / 1111 MEDLINE  
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[PMID]: 29434157
[Au] Autor:Yamamoto T; Ryuzaki H; Kobayashi S; Ohshiro S; Ogawa M; Tanaka N; Gotoda T; Moriyama M; Kinukawa N; Sugitani M; Notohara K
[Ad] Address:Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
[Ti] Title:A Case of Suspected Hepatically Localized Granulomatosis with Polyangiitis.
[So] Source:Intern Med;, 2018 Feb 09.
[Is] ISSN:1349-7235
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:The patient was a 72-year-old woman whose alkaline phosphatase levels had been elevated since she was 56 years old. Liver biopsies obtained when the patient was 64 and 66 years of age led to a suspicion of cholangitis caused by vasculitis. Furthermore, proteinase-3 anti-neutrophil cytoplasmic antibody positivity led to a suspicion of granulomatosis with polyangiitis, but subjective symptoms and disorders in other organs were absent, so this suspicion was not confirmed. Cholangitis caused by vasculitis rarely occurs without vasculitis in other organs. We herein report this case in which we obtained distinctive laparoscopic and imaging findings that raised suspicions of liver circulatory failure.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher
[do] DOI:10.2169/internalmedicine.9724-17


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