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[PMID]: 29524881
[Au] Autor:Liu Z; Yu D; Xu J; Li X; Wang X; He Z; Zhao T
[Ad] Address:Department of Plastic, The Second Affiliated Hospital of Soochow University, Suzhou, China; Department of the Burns and Plastic, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
[Ti] Title:Human umbilical cord mesenchymal stem cells improve irradiation-induced skin ulcers healing of rat models.
[So] Source:Biomed Pharmacother;101:729-736, 2018 Mar 07.
[Is] ISSN:1950-6007
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Irradiation-induced skin ulcers can be resultant from nuclear accident or reaction to radiation therapy of tumor and is intractable for healing. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been considered to be the potential therapeutic tools for tissue regeneration. However, the underlying mechanisms are still not well understood. This study aims to investigate the effects of hUC-MSCs on irradiation-induced skin ulcers healing and the related mechanisms. The ulcers were induced by irradiating the skin of adult SD rats. The ulcers of SD rats were treated with vehicle or hUC-MSCs donated from mother giving birth. The ulcer healing was measured by imaging the healing rate and the H&E staining. CD31 and VEGF expression was measured with immunohistochemistry assay. iTRAQ proteomics analysis was used to analyze the signaling pathway. The results showed that hUC-MSCs improved healing of irradiation-induced skin ulcers in vivo using a rat model of skin ulcer. Transplantation of hUC-MSCs promoted keratin generation and keratinocytes proliferation of ulcer areas. Furthermore, the results demonstrated that hUC-MSCs increased expression of CD31 and VEGF in ulcers and promoted neovascularization. iTRAQ proteomics analysis results indicated that PI3K/Akt signaling pathway involved in hUC-MSCs-mediated repairing of irradiation-induced skin ulcer. In conclusion, human umbilical cord mesenchymal stem cells promoted neovascularization and re-epithelization, and improved healing of irradiation-induced skin ulcers. This healing improvement may be conducted through activating the PI3K/Akt signaling pathway, however, which needs to be proven by the further investigations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524784
[Au] Autor:George Y; Aldeen M; Garnavi R
[Ad] Address:Department of Electric and Electronic Engineering, University of Melbourne, VIC, Australia. Electronic address: ygeorge@student.unimelb.edu.au.
[Ti] Title:Psoriasis image representation using patch-based dictionary learning for erythema severity scoring.
[So] Source:Comput Med Imaging Graph;66:44-55, 2018 Feb 23.
[Is] ISSN:1879-0771
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Psoriasis is a chronic skin disease which can be life-threatening. Accurate severity scoring helps dermatologists to decide on the treatment. In this paper, we present a semi-supervised computer-aided system for automatic erythema severity scoring in psoriasis images. Firstly, the unsupervised stage includes a novel image representation method. We construct a dictionary, which is then used in the sparse representation for local feature extraction. To acquire the final image representation vector, an aggregation method is exploited over the local features. Secondly, the supervised phase is where various multi-class machine learning (ML) classifiers are trained for erythema severity scoring. Finally, we compare the proposed system with two popular unsupervised feature extractor methods, namely: bag of visual words model (BoVWs) and AlexNet pretrained model. Root mean square error (RMSE) and F1 score are used as performance measures for the learned dictionaries and the trained ML models, respectively. A psoriasis image set consisting of 676 images, is used in this study. Experimental results demonstrate that the use of the proposed procedure can provide a setup where erythema scoring is accurate and consistent. Also, it is revealed that dictionaries with large number of atoms and small patch sizes yield the best representative erythema severity features. Further, random forest (RF) outperforms other classifiers with F1 score 0.71, followed by support vector machine (SVM) and boosting with 0.66 and 0.64 scores, respectively. Furthermore, the conducted comparative studies confirm the effectiveness of the proposed approach with improvement of 9% and 12% over BoVWs and AlexNet based features, respectively.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 706903 MEDLINE  
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[PMID]: 29524770
[Au] Autor:Bakonyi M; Gácsi A; Kovács A; Szucs MB; Berkó S; Csányi E
[Ad] Address:Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, H-6720, Hungary.
[Ti] Title:Following-up skin penetration of lidocaine from different vehicles by Raman spectroscopic mapping.
[So] Source:J Pharm Biomed Anal;154:1-6, 2018 Mar 06.
[Is] ISSN:1873-264X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The application of local anesthetics, usually administered by subcutaneous injection, is common in the course of diagnostic, therapeutic, and cosmetic dermatology procedures. The effective dermal delivery of lidocaine could offer a solution to many adverse effects caused by needle insertion, such as pain, local reactions or toxicity, and additionally, it avoids the disruption of anatomical landmarks. Therefore, novel dermal formulations of local anesthetics are needed to overcome the barrier function of the skin and provide sufficient and prolonged anesthesia. In our study, we aimed to investigate and compare the penetration profiles of four different lidocaine containing formulations (hydrogel, oleogel, lyotropic liquid crystal and nanostructured lipid carrier) by Raman microscopic mapping of the drug. The application of Raman spectroscopy provided information about the spatial distribution of lidocaine in the skin ex vivo. The penetration of lidocaine from lyotropic liquid crystal and nanostructured carrier reached deeper skin layers and a higher amount of the drug was diffused into the skin, compared with hydrogel and oleogel. This study confirmed that nanostructured carriers can improve skin penetration properties of lidocaine and proved the applicability of Raman spectroscopy in the research of dermatological preparations ex vivo as a nondestructive, relatively easy and fast technique.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524584
[Au] Autor:Elder DE; Piepkorn M; Barnhill RL; Longton GM; Nelson HD; Knezevich SR; Pepe MS; Carney PA; Titus LJ; Onega T; Tosteson ANA; Weinstock MA; Elmore JG
[Ad] Address:Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
[Ti] Title:Pathologist Characteristics Associated with Accuracy and Reproducibility of Melanocytic Skin Lesion Interpretation.
[So] Source:J Am Acad Dermatol;, 2018 Mar 07.
[Is] ISSN:1097-6787
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Diagnostic interpretations of melanocytic skin lesions vary widely among pathologists, yet the underlying reasons remain unclear. OBJECTIVE: Identify pathologist characteristics associated with rates of accuracy and reproducibility. METHODS: Pathologists independently interpreted the same set of biopsies of melanocytic lesions on two occasions. Diagnoses were categorized into one of five classes according to the MPATH-Dx system. Reproducibility was determined by pathologists' concordance of diagnoses across two occasions. Accuracy was defined by concordance with a consensus reference standard. Associations of pathologist characteristics with reproducibility and accuracy were assessed individually and in multivariable logistic regression models. RESULTS: Rates of diagnostic reproducibility and accuracy were highest among pathologists with board certification and/or fellowship training in dermatopathology, and those with ≥5 years of experience. In addition, accuracy was high among pathologists with higher caseload composition and volume of melanocytic lesions. LIMITATIONS: Data gathered in a test set situation using a classification tool not currently in clinical use. CONCLUSION: Diagnoses are more accurate among pathologists with specialty training and those with more experience interpreting melanocytic lesions. These findings support the practice of referring difficult cases to more experienced pathologists to improve diagnostic accuracy, although the impact on patient outcomes of these referrals requires additional research.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  5 / 706903 MEDLINE  
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[PMID]: 29524583
[Au] Autor:Chen L; Parsons AM; Aria AB; Ciurea AM; Patel AB; Chan C; Griffin JR; Nguyen TH; Migden MR
[Ad] Address:Department of Dermatology, The University of Texas McGovern Medical School at Houston, Houston, Texas.
[Ti] Title:Surgical Site Identification with Personal Digital Device: A Prospective Pilot Study.
[So] Source:J Am Acad Dermatol;, 2018 Mar 07.
[Is] ISSN:1097-6787
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Various means to facilitate accurate biopsy site identification have been proposed. OBJECTIVE: To determine the accuracy of biopsy site identification using photos taken with a patient's digital device by a dermatologist versus professional medical photography. METHODS: Photographs of circled biopsy sites were taken with personal digital devices by the principal investigator (PI). Another set of photographs were taken by a professional photographer. Secondary photographs were taken of the biopsy site location pointed to by the staff and PI based on the personal digital device image and professional medical photography, respectively. Based on secondary photographs, two independent dermatologists determined if the skin biopsy locations pointed out by the staff were consistent with the ones pointed out by PI. RESULTS: Per Dermatologist A, the staff correctly identified all 53/53 biopsy sites. Per Dermatologist B, the staff were correct on 51/53 observations. Dermatologist C, the final arbiter, concurred with Dermatologist A in the two cases that Dermatologist B was not certain of the biopsy site location. LIMITATIONS: The mean interval from initial biopsy to re-identification of the site was 36.2 days. CONCLUSION: Utilizing patients' personal digital devices is a cost-effective, HIPAA compliant, and readily available means to identify skin biopsy sites.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  6 / 706903 MEDLINE  
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[PMID]: 29524559
[Au] Autor:Greenhawt M; Chan ES; Fleischer DM; Hicks A; Wilson R; Shaker M; Venter C; Stukus D
[Ad] Address:Children's Hospital Colorado, University of Colorado School of Medicine, Section of Allergy and Immunology, Aurora, CO. Electronic address: Matthew.Greenhawt@childrenscolorado.org.
[Ti] Title:Caregiver and expecting caregiver support for early peanut introduction guidelines.
[So] Source:Ann Allergy Asthma Immunol;, 2018 Mar 07.
[Is] ISSN:1534-4436
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Recent guidelines recommend early peanut introduction (EPI) beginning around 4-6 months in infants with either severe eczema and/or egg allergy, and around 6 months for all other infants. Caregiver preferences for such practices are unkown. METHODS: We explored preferences for EPI and in-office allergy risk assessment (IRA) through a nationally-representative survey of expecting (n=1000) and new caregivers of infants < 1 year (n=1000). RESULTS: Among a primarily female (99.7%), married (80.3%), and white (74.4%) sample, 29% had no/vague awareness of the new guidelines, 61% had no/minimal concern for their child developing food allergy, but 54% felt timing of introduction has moderate/strong importance for developing food allergy. Only 31% expressed willingness for EPI before/around 6 months of life, with 40% reporting willingness to introduce peanut after 11 months of life, similar to tree nuts and seafood. However, 60% reported willingness to introduce egg before 8 months. 51% and 56.8% were unwilling to allow IRA methods such as skin testing and oral challenge before 11 months of life, respectively. Odds of willingness to both delay peanut introduction and undergo challenge after 6 months of life were lower among expecting caregivers (OR 0.79, CI 0.65-0.96; OR 0.67, CI 0.54-0.82, respectively). CONCLUSIONS: Among new and expecting caregivers, there is poor current willingness and questionable support for early allergenic solid food recommendations, including IRA before introduction. Willingness was better among expecting versus current caregivers. These trends underscore a need for broader formal implementation planning to facilitate early allergen introduction and maximize its preventive benefits.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  7 / 706903 MEDLINE  
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[PMID]: 29524484
[Au] Autor:Shivaprasad C; Amit G; Anish K; Rakesh B; Anupam B; Aiswarya Y
[Ad] Address:Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India. Electronic address: shvprsd.c@gmail.com.
[Ti] Title:Clinical correlates of sudomotor dysfunction in patients with type 2 diabetes and peripheral neuropathy.
[So] Source:Diabetes Res Clin Pract;, 2018 Mar 07.
[Is] ISSN:1872-8227
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:AIMS: To investigate the factors associated with abnormal electrochemical skin conductance (ESC) in patients with type 2 diabetes mellitus (T2D) and early diabetic peripheral neuropathy (DPN). METHODS: We recruited 523 consecutive patients with T2D (median age: 50 [interquartile range: 16] years; median T2D duration: 4 [5] years). Sudomotor dysfunction was defined as an ESC <60 µS, and DPN as a neuropathy disability score (NDS) ≥6. Logistic regression was performed to determine the predictors of sudomotor dysfunction in patients with DPN. RESULTS: The prevalence of sudomotor dysfunction was 29% for all patients and 84.5% for patients with DPN. A significant negative correlation was observed between the NDS and ESC measurements (r = -0.52, p < 0.0001). In the univariate analysis, abnormal ESC measures were associated with age, diabetes duration, glycated hemoglobin, diabetic retinopathy, insulin therapy, and foot abnormalities. In the multivariate analysis, ESC abnormalities were associated with age, diabetes duration, glycated hemoglobin levels, insulin therapy, and foot deformities. There was a robust association between foot deformities and abnormal ESC (p = 0.049; odds ratio = 16.02) in patients with DPN. CONCLUSION: Sudomotor dysfunction is highly prevalent in patients with T2D, especially in those with DPN. Various diabetes-related factors were linked to lower ESC values, indicating an association between chronic hyperglycemia and sudomotor function. We also observed a strong relationship between foot deformities and ESC abnormalities. We conclude that the factors associated with DPN are also relevant to sudomotor dysfunction.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  8 / 706903 MEDLINE  
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[PMID]: 29524457
[Au] Autor:Pandeya N; Kvaskoff M; Olsen CM; Green AC; Perry S; Baxter C; Davis MB; Mortimore R; Westacott L; Wood D; Triscott J; Williamson R; Whiteman DC
[Ad] Address:Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Public Health, The University of Queensland, Herston, QLD 4006, Australia.
[Ti] Title:Factors related to nevus-associated cutaneous melanoma: a case-case study.
[So] Source:J Invest Dermatol;, 2018 Mar 07.
[Is] ISSN:1523-1747
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A proportion of cutaneous melanomas display neval remnants on histologic examination. Converging lines of epidemiologic and molecular evidence suggest that melanomas arising from nevus precursors differ from melanomas arising de novo. In a large, population-based study comprising 636 cutaneous melanomas subjected to dermatopathology review, we explored the molecular, host and environmental factors associated with the presence of neval remnants. We found nevus-associated melanomas were significantly associated with younger age at presentation, non-brown eye color, trunk site, thickness <0.5mm and BRAF mutation. Compared with patients with de novo melanomas, those with nevus-associated tumors were more likely to self-report many moles on their skin as a teenager (OR 1.94, 95% CI 1.01-3.72) but less likely to report many facial freckles (OR 0.49, 95% CI 0.25-0.96). They also had high total nevus counts (OR 2.18, 95% CI 1.26-3.78). On histologic examination, nevus-associated melanomas exhibited less dermal elastosis in adjacent skin compared with de novo melanomas (OR 0.55, 95% CI 0.30-1.01). These epidemiologic data accord with the emerging molecular paradigm that nevus-associated melanomas arise through a distinct sequence of causal events which differ from those leading to other cutaneous melanomas.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  9 / 706903 MEDLINE  
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[PMID]: 29524423
[Au] Autor:Lee JH; Jeon YD; Lee YM; Kim DK
[Ad] Address:Department of Immunology and Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeollabuk-do 54907, Republic of Korea.
[Ti] Title:The suppressive effect of puerarin on atopic dermatitis-like skin lesions through regulation of inflammatory mediators in vitro and in vivo.
[So] Source:Biochem Biophys Res Commun;, 2018 Mar 07.
[Is] ISSN:1090-2104
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Atopic dermatitis (AD) is one of the common inflammatory immune disorders. Puerarin is the main isoflavonoid obtained from the root of Pueraria lobata and has been known have ameliorative effects on diverse inflammatory diseases. However, the effects of puerarin on AD have not been uncovered. 2,4-dinitrochlorobenzene (DNCB) was used to induce atopic dermatitis(AD)-like skin lesions on BALB/c mice for 17 days. Further, the BALB/c mice were orally administered puerarin. Puerarin ameliorated DNCB-induced AD-like symptoms in the mice by regulating skin thickness, degranulation of mast cells, and serum immunoglobulin E (IgE). Human keratinocytes (HaCaT cells) were also used to clarify the effects of puerarin on the secretion of pro-inflammatory cytokines. Puerarin inhibited the secretion of inflammatory cytokines and chemokines. The aim of this study was to investigate the protective and alleviative effect of puerarin on AD in vitro and in vivo. The results in this study indicated that puerarin ameliorates AD-like skin lesion and skin inflammation via regulation of various atopic and inflammatory mediators. Therefore, puerarin might be useful in treating AD and other skin diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29524371
[Au] Autor:Gróf M; Vagasová T; Oltman M; Skladaný L; Malická L
[Ad] Address:Faculty of Economics, Technical University of Kosice, Kosice, Slovak Republic.
[Ti] Title:Inequalities in Cancer Deaths by Age, Gender and Education.
[So] Source:Cent Eur J Public Health;25 Suppl 2:S59-S63, 2017 Dec.
[Is] ISSN:1210-7778
[Cp] Country of publication:Czech Republic
[La] Language:eng
[Ab] Abstract:AIM: The economy of each state provides a significant amount of money into the health care system with the aim of knowing the health status of its population in the context of socioeconomic characteristics for effective resource allocation. In recent years, there is a growing number of cancer deaths in Slovakia. Therefore, the structure of cancer deaths according to its primary determinants, such as age, sex and education with the aim of effective implementation of prevention programs in Slovakia was examined. METHODS: Main source of data on deaths from 1996 to 2014 was provided by National Health Information Centre in Slovakia. However, data were available only from 2011. Standardized mortality rate per 100,000 inhabitants was estimated by the method of direct standardization using European standard population. The R project for statistical computing was used for calculation of statistically significant differences among various groups of mortality. RESULTS: The results show that people with primary education die from cancer later than people with higher education. However, major differences related to both sex and age are present in people with university education. A different variety of cancers occur in childhood (neoplasm of brain), adolescents (neoplasm of bone), young adults (neoplasm of brain), or adults (lung cancer and breast cancer). Malignant neoplasm of brain was more prevalent at higher education levels, Malignant neoplasm of bladder and Malignant melanoma of skin were more prevalent at the university level of education. CONCLUSIONS: The results can be useful for economists to define the health priorities in each country, make the financial decisions in economics, and thus contribute to better health, economic growth, as well as effective spending of health expenditures.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review
[do] DOI:10.21101/cejph.a5055


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