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[PMID]: 25024719
[Au] Autor:Shim TS
[Ad] Address:Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
[Ti] Title:Diagnosis and Treatment of Latent Tuberculosis Infection due to Initiation of Anti-TNF Therapy.
[So] Source:Tuberc Respir Dis (Seoul);76(6):261-8, 2014 Jun.
[Is] ISSN:1738-3536
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Patients with immune-mediated inflammatory diseases (IMIDs) are increasingly being treated with anti-tumor necrosis factor (TNF) agents and are at increased risk of developing tuberculosis (TB). Therefore, diagnosis and treatment of latent TB infection (LTBI) is recommended in these patients due to the initiation of anti-TNF therapy. Traditionally, LTBI has been diagnosed on the basis of clinical factors and a tuberculin skin test. Recently, interferon-gamma releasing assays (IGRAs) that can detect TB infection have become available. Considering the high-risk of developing TB in patients on anti-TNF therapy, the use of both a tuberculin skin test and an IGRA should be considered to detect and treat LTBI in patients with IMIDs. The traditional LTBI treatment regimen consisted of isoniazid monotherapy for 9 months. However, shorter regimens such as 4 months of rifampicin or 3 months of isoniazid/rifampicin are increasingly being used to improve treatment completion rates. In this review, the screening methods for diagnosing latent and active TB before anti-TNF therapy in patients with IMIDs will be briefly described, as well as the current LTBI treatment regimens, the recommendations for managing TB that develops during anti-TNF therapy, the necessity of regular monitoring to detect new TB infection, and the re-initiation of anti-TNF therapy in patients who develop TB.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1407
[Da] Date of entry for processing:140715
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4046/trd.2014.76.6.261

  2 / 591328 MEDLINE  
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[PMID]: 24918616
[Au] Autor:Mathes DW; Chang J; Hwang B; Graves SS; Storer BE; Butts-Miwongtum T; Sale GE; Storb R
[Ad] Address:1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA. 2 Department of Surgery, University of Washington, Seattle, WA. 3 Plastic Surgery Service, VA Puget Sound Health Care System, Seattle, WA. 4 Department of Medicine, University of Washington, Seattle, WA. 5 School of Public Health, University of Washington, Seattle, WA. 6 Department of Pathology, University of Washington, Seattle, WA. 7 Address correspondence to: David W. Mathes, M.D., Clinical Research Division, Fred Hutchinson Cancer Research Center, PO Box 19024; D1-100 1100 Fairview Ave, N, Seattle, WA 98109.
[Ti] Title:Simultaneous transplantation of hematopoietic stem cells and a vascularized composite allograft leads to tolerance.
[So] Source:Transplantation;98(2):131-8, 2014 Jul 27.
[Is] ISSN:1534-6080
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: We have previously demonstrated that tolerance to a vascularized composite allograft (VCA) can be achieved after the establishment of mixed chimerism. We test the hypothesis that tolerance to a VCA in our dog leukocyte antigen-matched canine model is not dependent on the previous establishment of mixed chimerism and can be induced coincident with hematopoietic cell transplantation (HCT). METHODS: Eight dog leukocyte antigen-matched, minor antigen mismatched dogs received 200 cGy of radiation and a VCA transplant. Four dogs received donor bone marrow at the time of VCA transplantation (group 1), whereas a second group of four dogs did not (group 2). All recipients received a limited course of postgrafting immunosuppression. All dogs that received HCT and VCA were given donor, third-party, and autologous skin grafts. RESULTS: All group 1 recipients were tolerant to their VCA (>62 weeks). Three of the four dogs in group 2 rejected their VCA transplants after the cessation of immunosuppression. Biopsies obtained from the muscle and skin of VCA from group 1 showed few infiltrating cells compared with extensive infiltrates in biopsies of VCA from group 2. Compared with autologous skin and muscle, elevated levels of CD3+ FoxP3+ T-regulatory cells were found in the skin and muscle obtained from the VCA of HCT recipients. All group 1 animals were tolerant to their donor skin graft and promptly rejected the third-party skin grafts. CONCLUSION: These data demonstrated that donor-specific tolerance to all components of the VCA can be established through simultaneous nonmyeloablative allogeneic HCT and VCA transplantation protocol.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1097/TP.0000000000000204

  3 / 591328 MEDLINE  
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[PMID]: 25019942
[Au] Autor:Chan TY
[Ad] Address:Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China. tykchan@cuhk.edu.hk.
[Ti] Title:Large outbreaks of ciguatera after consumption of brown marbled grouper.
[So] Source:Toxins (Basel);6(7):2041-9, 2014.
[Is] ISSN:2072-6651
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Brown marbled grouper (Epinephelus fuscoguttatus) is an apex predator from coral reefs of the Indo-Pacific region. All five published case series of ciguatera after consumption of brown marbled grouper were reviewed to characterize the types, severity and chronicity of ciguatera symptoms associated with its consumption. Three of these case series were from large outbreaks affecting over 100-200 subjects who had eaten this reef fish served at banquets. Affected subjects generally developed a combination of gastrointestinal, neurological and, less commonly, cardiovascular symptoms. Gastrointestinal symptoms occurred early and generally subsided in 1-2 days. Some neurological symptoms (e.g., paresthesia of four limbs) could last for weeks or months. Sinus bradycardia and hypotension occurred early, but could be severe and prolonged, necessitating the timely use of intravenous fluids, atropine and dopamine. Other cardiovascular and neurological features included atrial ectopics, ventricular ectopics, dyspnea, chest tightness, PR interval >0.2 s, ST segment changes, polymyositis and coma. Concomitant alcohol consumption was associated with a much higher risk of developing bradycardia, hypotension and altered skin sensation. The public should realize that consumption of the high-risk fish (especially the ciguatoxin-rich parts and together with alcohol use) and repeated ciguatoxin exposures will result in more severe and chronic illness.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3390/toxins6072041

  4 / 591328 MEDLINE  
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[PMID]: 24043394
[Au] Autor:Kinoshita S; Kyoda S; Hirano A; Akiba T; Nojima K; Uchida K; Takeyama H; Morikawa T
[Ad] Address:Department of Surgery, Jikei University Kashiwa Hospital, 163-1 Kashiwashita, Kashiwa, Chiba, 277-8567, Japan, satokino@jikei.ac.jp.
[Ti] Title:Clinical comparison of four types of skin incisions for skin-sparing mastectomy and immediate breast reconstruction.
[So] Source:Surg Today;44(8):1470-5, 2014 Aug.
[Is] ISSN:1436-2813
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:PURPOSE: Skin-sparing mastectomy (SSM) and immediate breast reconstruction (IBR) has become popular as an effective procedure for patients with early breast cancer. We herein report an overview of the four types of skin incisions used for SSM. METHODS: The records of 111 consecutive breast cancer patients, who received SSM and IBR from 2003 to 2012, were reviewed retrospectively. Four types of skin incisions were used. Type A was the so-called tennis racquet incision, type B was a periareolar incision and mid-axillary incision, type C was the so-called areola-sparing with mid-axillary incision and type D was a small transverse elliptical incision and transverse axillary incision. RESULTS: Twenty-six type A, 59 type B, 20 type C and six type D incisions were made. The average blood loss and average length of the operation during SSM were not significantly different between the four approaches. The average areolar diameter was 35 mm for type A, B and D incisions, and 45 mm for type C. There was a need for postoperative nipple-areolar complex plasty (NAC-P) in 75 % of the cases following type A, B and D incisions, and 35 % of the cases treated using type C incisions. CONCLUSION: The type C incision is superior with regard to the cost and cosmetic outcomes, because fewer of these patients request postoperative NAC-P.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s00595-013-0722-2

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[PMID]: 23886885
[Au] Autor:Ene N; Bélénotti P; Benyamine A; Sovaila S; Ben Sahla Talet MH; Kaminsky P; Serratrice J; Weiller PJ
[Ad] Address:Service de médecine interne, CHU Timone, 264, rue Saint-Pierre, 13385 Marseille cedex, France....
[Ti] Title:Forme pseudo-pathomimique de granulomatose avec polyangéite (anciennement maladie de Wegener). [Granulomatosis with polyangiitis (previously Wegener's granulomatosis) mimicking malingering].
[So] Source:Rev Med Interne;35(8):540-2, 2014 Aug.
[Is] ISSN:1768-3122
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:INTRODUCTION: ANCA vasculitis may involve the skin and develop slowly without specific histology, and without autoantibodies. CASE REPORT: We report a 50-year-old woman who experienced bilateral mastectomy because of ulcero-necrotic, non-specific inflammatory cutaneous lesions of the breasts. First considered by others as a malinger patient, she developed oto-neurological lesions leading to the diagnosis of Wegener's granulomatosis. Five years later, specific antibodies of the disease were present. CONCLUSION: Cutaneous involvement by ANCA vasculitis can be isolated for a long time. Physicians must have a high degree of suspicion to avoid diagnostic delay of ANCA vasculitis.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 591328 MEDLINE  
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[PMID]: 25024916
[Au] Autor:Meadow JF; Altrichter AE; Green JL
[Ad] Address:Biology and the Built Environment Center, Institute of Ecology and Evolution, University of Oregon , Eugene, OR , USA.
[Ti] Title:Mobile phones carry the personal microbiome of their owners.
[So] Source:PeerJ;2:e447, 2014.
[Is] ISSN:2167-8359
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Most people on the planet own mobile phones, and these devices are increasingly being utilized to gather data relevant to our personal health, behavior, and environment. During an educational workshop, we investigated the utility of mobile phones to gather data about the personal microbiome - the collection of microorganisms associated with the personal effects of an individual. We characterized microbial communities on smartphone touchscreens to determine whether there was significant overlap with the skin microbiome sampled directly from their owners. We found that about 22% of the bacterial taxa on participants' fingers were also present on their own phones, as compared to 17% they shared on average with other people's phones. When considered as a group, bacterial communities on men's phones were significantly different from those on their fingers, while women's were not. Yet when considered on an individual level, men and women both shared significantly more of their bacterial communities with their own phones than with anyone else's. In fact, 82% of the OTUs were shared between a person's index and phone when considering the dominant taxa (OTUs with more than 0.1% of the sequences in an individual's dataset). Our results suggest that mobile phones hold untapped potential as personal microbiome sensors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Da] Date of entry for processing:140715
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.7717/peerj.447

  7 / 591328 MEDLINE  
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[PMID]: 25020161
[Au] Autor:Song SE; Yang J; Lee KS; Kim H; Kim YM; Kim S; Park MS; Oh SY; Lee JB; Lee E; Park SH; Kim HJ
[Ad] Address:Division of Tuberculosis and Bacterial Respiratory Infections, Korea National Institute of Health, Cheongwon-gun, Chungcheongbuk-Do, Republic of Korea....
[Ti] Title:Comparison of the Tuberculin Skin Test and Interferon Gamma Release Assay for the Screening of Tuberculosis in Adolescents in Close Contact with Tuberculosis TB Patients.
[So] Source:PLoS One;9(7):e100267, 2014.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: The tuberculin skin test (TST) frequently yields false positive results among BCG-vaccinated persons thereby limiting its diagnostic value particularly in settings with high BCG vaccination rate. We determined the agreement between IGRA and TST using 2 cutoff values and identified possible relationships between the results of these tests and the development of active tuberculosis. METHODOLOGY: Adolescents aged 11-19 years in close contact with smear-positive tuberculosis cases and with normal chest radiographs were recruited from middle and high schools in South Korea. The TST was conducted by trained nurses, and blood was drawn for the QuantiFERON-TB Gold In-Tube (QFT-GIT). Participants were followed up for 2 years to check for incidence tuberculosis. RESULTS: A total of 2,982 subjects were included in the study, the average age was 15.1 years (SD 1.3), 61% had BCG vaccination scars. The agreement of QFT-GIT and the TST was low (κ = 0.38, 95% CI 0.32 to 0.42) using 10 mm cutoff; however, when the 15 mm cutoff was used, the agreement was intermediate (κ = 0.56, 95% CI 0.50 to 0.61). The odds ratio (OR) for the development of active tuberculosis was 7.9 (95% CI 3.46 to 18.06) for QFT-GIT positive patients, 7.96 (95% CI 3.14-20.22) for TST/QFT-GIT+ and the OR 4.62 (95% CI 2.02 to 10.58) and 16.35 (95% CI 7.09 to 37.71) for TST 10 mm and 15 mm cutoff respectively. CONCLUSIONS: The results of this study suggest that the TST cutoff point for patients aged 11-17 years would be 15 mm in other study. The OR of QFT-GIT for the development of active tuberculosis and its intermediate agreement with TST using 15 mm cutoff demonstrates its role as an adjunct diagnostic tool to current clinical practice. Positive responders to both TST and QFT-GIT at the outset may benefit from chemoprophylaxis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pone.0100267

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[PMID]: 25020137
[Au] Autor:Cui YY; Xu H; Wu HH; Qi J; Shi J; Li YQ
[Ad] Address:Department of Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an, China; Institution of Basic Medical Science and Lab of Cell Biology & Translational Medicine, Xi'an Medical University, Xi'an, China....
[Ti] Title:Spatio-temporal expression and functional involvement of transient receptor potential vanilloid 1 in diabetic mechanical allodynia in rats.
[So] Source:PLoS One;9(7):e102052, 2014.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Diabetic neuropathic pain (DNP) is one of the most common clinical manifestations of diabetes mellitus (DM), which is characterized by prominent mechanical allodynia (DMA). However, the molecular mechanism underlying it has not fully been elucidated. In this study, we examined the spatio-temporal expression of a major nociceptive channel protein transient receptor potential vanilloid 1 (TRPV1) and analyzed its functional involvement by intrathecal (i.t.) application of TRPV1 antagonists in streptozocin (STZ)-induced DMA rat models. Western blot and immunofluorescent staining results showed that TRPV1 protein level was significantly increased in the soma of the dorsal root ganglion (DRG) neurons on 14 days after STZ treatment (DMA 14 d), whereas those in spinal cord and skin (mainly from the central and peripheral processes of DRG neurons) had already been enhanced on DMA 7 d to peak on DMA 14 d. qRT-PCR experiments confirmed that TRPV1 mRNA level was significantly up-regulated in the DRG on DMA 7 d, indicating a preceding translation of TRPV1 protein in the soma but preferential distribution of this protein to the processes under the DMA conditions. Cell counting assay based on double immunostaining suggested that increased TRPV1-immunoreactive neurons were likely to be small-sized and CGRP-ergic. Finally, single or multiple intrathecal applications of non-specific or specific TRPV1 antagonists, ruthenium red and capsazepine, at varying doses, effectively alleviated DMA, although the effect of the former was more prominent and long-lasting. These results collectively indicate that TRPV1 expression dynamically changes during the development of DMA and this protein may play important roles in mechanical nociception in DRG neurons, presumably through facilitating the release of CGRP.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pone.0102052

  9 / 591328 MEDLINE  
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[PMID]: 25024146
[Au] Autor:Gettinger RD
[Ad] Address:Laboratory of Biomedical and Environmental Sciences, University of California and Biology Department, 90024, Los Angeles, CA, USA.
[Ti] Title:Use of doubly-labeled water ((3)HH (18)O) for determination of H 2O flux and CO 2 production by a mammal in a humid environment.
[So] Source:Oecologia;59(1):54-7, 1983 Aug.
[Is] ISSN:0029-8549
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:The accuracy of the doubly labeled water ((3)HH(18)O) technique for estimating H2O flux and CO2 production in pocket gophers was evaluated in laboratory experiments. Experiments were conducted under conditions of elevated humidity in order to determine the influence of unlabeled H2O vapor input on H2O flux and CO2 production rates which are determined from isotope turnover. High humidity is commonplace in burrows of many small mammals, including those of the pocket gopher, and theoretically could introduce substantial errors when determining these rates with isotopic procedures.Water influx that was estimated from tritium turnover was not significantly different from actual H2O influx which was determined from feeding rates. Also, (3)HH(18)O techniques yielded estimates of CO2 production that were not significantly different from values determined from energy intake rates. Such close agreement was not anticipated. The unexpected accuracy probably results due to offsetting errors associated with (1) the influx of unlabeled H2O vapor through the skin and lungs of labeled pocket gophers and (2) the effects of biological fractionation of isotopes in the body H2O of labeled pocket gophers.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[St] Status:In-Data-Review
[do] DOI:10.1007/BF00388071

  10 / 591328 MEDLINE  
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[PMID]: 25022347
[Au] Autor:Dasgeb B; Smirnov AV; Ardeshirpour Y; Sackett DL; Knutson JR; Mehregan D; Gandjbakhche A; Halpern AC
[Ti] Title:Multiscale BerEp4 Molecular Imaging of Microtumor Phantoms: Toward Theranostics for Basal Cell Carcinoma.
[So] Source:Mol Imaging;13(0):1-9, 2014 Jul 1.
[Is] ISSN:1536-0121
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:AbstractBasal cell carcinoma (BCC), the most common cancer in humans, appears macroscopically and microscopically similar to many other skin lesions, which makes differential diagnosis difficult. We are developing an approach for quantitative molecular imaging of BerEP4, a transmembrane biomarker for BCC, with the goal of increasing the precision and accuracy of diagnosis. This pilot study was conducted to assess the affinity and selectivity of BerEp4 antibody and assess its possible use in designing theranostic probes for BCC. We provide evidence that our photon-counting fluorescence macrodetection system can recover specific signal increases from a film/pellet phantom. Additionally, we show that a two-photon excited fluorescence /backscatter confocal microscopy system can image BerEP4 antibody/antigen complex on the surface of BerEP4-expressing cancer cells in three dimensions. Based on the initial results, BerEP4 seems to be a promising biomarker for molecular imaging of BCC. To prepare BerEP4 for eventual theranostic use, we examined the feasibility of a combined macro-/micro-optical approach to imaging BCC with various histologies. These optical methods, endowed with the ability to monitor treatment in real time, may open an opportunity for noninvasive diagnosis, treatments, and follow-up.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review


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