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[PMID]: 25327261
[Au] Autor:Ibrahim MM; Bond J; Bergeron A; Miller KJ; Ehanire T; Quiles C; Lorden ER; Medina MA; Fisher M; Klitzman B; Selim MA; Leong KW; Levinson H
[Ad] Address:Division of Plastic and Reconstructive Surgery, Department of Surgery, Duke University School of Medicine, Durham, North Carolina.
[Ti] Title:A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies.
[So] Source:Wound Repair Regen;22(6):755-64, 2014 Nov.
[Is] ISSN:1524-475X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hypertrophic scar (HSc) contraction following burn injury causes contractures. Contractures are painful and disfiguring. Current therapies are marginally effective. To study pathogenesis and develop new therapies, a murine model is needed. We have created a validated immune-competent murine HSc model. A third-degree burn was created on dorsum of C57BL/6 mice. Three days postburn, tissue was excised and grafted with ear skin. Graft contraction was analyzed and tissue harvested on different time points. Outcomes were compared with human condition to validate the model. To confirm graft survival, green fluorescent protein (GFP) mice were used, and histologic analysis was performed to differentiate between ear and back skin. Role of panniculus carnosus in contraction was analyzed. Cellularity was assessed with 4',6-diamidino-2-phenylindole. Collagen maturation was assessed with Picro-sirius red. Mast cells were stained with Toluidine blue. Macrophages were detected with F4/80 immune. Vascularity was assessed with CD31 immune. RNA for contractile proteins was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Elastic moduli of skin and scar tissue were analyzed using a microstrain analyzer. Grafts contracted to ∼45% of their original size by day 14 and maintained their size. Grafting of GFP mouse skin onto wild-type mice, and analysis of dermal thickness and hair follicle density, confirmed graft survival. Interestingly, hair follicles disappeared after grafting and regenerated in ear skin configuration by day 30. Radiological analysis revealed that panniculus carnosus doesn't contribute to contraction. Microscopic analyses showed that grafts show increase in cellularity. Granulation tissue formed after day 3. Collagen analysis revealed increases in collagen maturation over time. CD31 stain revealed increased vascularity. Macrophages and mast cells were increased. qRT-PCR showed up-regulation of transforming growth factor beta, alpha smooth muscle actin, and rho-associated protein kinase 2 in HSc. Tensile testing revealed that human skin and scar tissues are tougher than mouse skin and scar tissues.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/wrr.12238

  2 / 604807 MEDLINE  
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[PMID]: 25130506
[Au] Autor:Shamouelian D; Leary RP; Manuel CT; Harb R; Protsenko DE; Wong BJ
[Ad] Address:Department of Otolaryngology, University of California at Irvine, Irvine, California.
[Ti] Title:Rethinking nasal tip support: A finite element analysis.
[So] Source:Laryngoscope;125(2):326-30, 2015 Feb.
[Is] ISSN:1531-4995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: We employ a nasal tip finite element model (FEM) to evaluate contributions of two of the three major tip support mechanisms: attachments between the upper and lower lateral cartilages and attachment of the medial crura to the caudal septum. STUDY DESIGN: The nasal tip FEM computed stress distribution and strain energy density (SED) during nasal tip compression. We examined the impact of attachments between the upper and lower lateral cartilages and the attachment of the medial crura to the caudal septum on nasal tip support. METHODS: The FEM consisted of three tissue components: bone, cartilage, and skin. Four models were created: A) control model with attachments present at the scroll and caudal septum; B) simulated disruption of scroll; C) simulated disruption of medial crura attachments to caudal septum; and D) simulated disruption of scroll and medial crura attachments to caudal septum. Spatial distribution of stress and SED were calculated. RESULTS: The keystone, intermediate crura, caudal septum, and nasal spine demonstrated high concentration of stress distribution. Across all models, there was no difference in stress distribution. Disruption of the scroll resulted in 1% decrease in SED. Disruption of the medial crura attachments to the caudal septum resulted in 4.2% reduction in SED. Disruption of both scroll and medial crural attachments resulted in 9.1% reduction in SED. CONCLUSION: The nasal tip FEM is an evolving tool to study structural nasal tip dynamics and demonstrates the loss of nasal tip support with disruption of attachments at the scroll and nasal base. LEVEL OF EVIDENCE: N/A Laryngoscope, 125:326-330, 2015.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1002/lary.24845

  3 / 604807 MEDLINE  
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[PMID]: 25174802
[Au] Autor:Gao Y; Tuvblad C; Schell A; Baker L; Raine A
[Ad] Address:Department of Psychology, Brooklyn College and the Graduate Center of the City University of New York, Brooklyn, New York, USA.
[Ti] Title:Skin conductance fear conditioning impairments and aggression: A longitudinal study.
[So] Source:Psychophysiology;52(2):288-95, 2015 Feb.
[Is] ISSN:1540-5958
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Autonomic fear conditioning deficits have been linked to child aggression and adult criminal behavior. However, it is unknown if fear conditioning deficits are specific to certain subtypes of aggression, and longitudinal research is rare. In the current study, reactive and proactive aggression were assessed in a sample of males and females when aged 10, 12, 15, and 18 years old. Skin conductance fear conditioning data were collected when they were 18 years old. Individuals who were persistently high on proactive aggression measures had significantly poorer conditioned responses at 18 years old when compared to others. This association was not found for reactive aggression. Consistent with prior literature, findings suggest that persistent antisocial individuals have unique neurobiological characteristics and that poor autonomic fear conditioning is associated with the presence of increased instrumental aggressive behavior.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/psyp.12322

  4 / 604807 MEDLINE  
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[PMID]: 25559426
[Au] Autor:Oakley E; Wrazen B; Bellnier DA; Syed Y; Arshad H; Shafirstein G
[Ad] Address:Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York.
[Ti] Title:A new finite element approach for near real-time simulation of light propagation in locally advanced head and neck tumors.
[So] Source:Lasers Surg Med;47(1):60-7, 2015 Jan.
[Is] ISSN:1096-9101
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND AND OBJECTIVES: Several clinical studies suggest that interstitial photodynamic therapy (I-PDT) may benefit patients with locally advanced head and neck cancer (LAHNC). For I-PDT, the therapeutic light is delivered through optical fibers inserted into the target tumor. The complex anatomy of the head and neck requires careful planning of fiber insertions. Often the fibers' location and tumor optical properties may vary from the original plan therefore pretreatment planning needs near real-time updating to account for any changes. The purpose of this work was to develop a finite element analysis (FEA) approach for near real-time simulation of light propagation in LAHNC. METHODS: Our previously developed FEA for modeling light propagation in skin tissue was modified to simulate light propagation from interstitial optical fibers. The modified model was validated by comparing the calculations with measurements in a phantom mimicking tumor optical properties. We investigated the impact of mesh element size and growth rate on the computation time, and defined optimal settings for the FEA. We demonstrated how the optimized FEA can be used for simulating light propagation in two cases of LAHNC amenable to I-PDT, as proof-of-concept. RESULTS: The modified FEA was in agreement with the measurements (P = 0.0271). The optimal maximum mesh size and growth rate were 0.005-0.02 m and 2-2.5 m/m, respectively. Using these settings the computation time for simulating light propagation in LAHNC was reduced from 25.9 to 3.7 minutes in one case, and 10.1 to 4 minutes in another case. There were minor differences (1.62%, 1.13%) between the radiant exposures calculated with either mesh in both cases. CONCLUSIONS: Our FEA approach can be used to model light propagation from diffused optical fibers in complex heterogeneous geometries representing LAHNC. There is a range of maximum element size (MES) and maximum element growth rate (MEGR) that can be used to minimize the computation time of the FEA to 4 minutes. Lasers Surg. Med. 47:60-67, 2015. © 2015 Wiley Periodicals, Inc.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1002/lsm.22313

  5 / 604807 MEDLINE  
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[PMID]: 25457179
[Au] Autor:Gonzalez DJ; Corriden R; Akong-Moore K; Olson J; Dorrestein PC; Nizet V
[Ti] Title:N-terminal ArgD peptides from the classical Staphylococcus aureus Agr system have cytotoxic and proinflammatory activities.
[So] Source:Chem Biol;21(11):1457-62, 2014 Nov 20.
[Is] ISSN:1879-1301
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:AgrD is the precursor for the autoinducing peptide in a quorum-sensing system regulating virulence phenotypes of the preeminent pathogen Staphylococcus aureus. Mass spectrometry-based methods, including molecular networking, identified formylated and nonformylated peptide variants derived from the AgrD N-terminal leader domain in S. aureus cell-free culture supernatants. Functional assessment of these peptides revealed unexpected bioactivities, including human cell-line cytotoxicity, modulation of neutrophil chemotaxis, neutrophil extracellular trap formation, and the aggravation of skin lesions in vivo.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1016/j.chembiol.2014.09.015

  6 / 604807 MEDLINE  
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[PMID]: 25610853
[Au] Autor:Marotta N; Landi A; Mancarella C; Rocco P; Pietrantonio A; Galati G; Bolognese A; Delfini R
[Ad] Address:Nicola Marotta, Alessandro Landi, Cristina Mancarella, Pierluigi Rocco, Andrea Pietrantonio, Roberto Delfini, Depa-rtment of Neurology and Psychiatry, Division of Neurosurgery, Policlinico Umberto I, "La Sapienza" Università di Roma, 00161 Rome, Italy....
[Ti] Title:Giant xanthogranuloma of the pelvis with S1 origin: Complete removal with only posterior approach, technical note.
[So] Source:World J Clin Cases;3(1):77-80, 2015 Jan 16.
[Is] ISSN:2307-8960
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Xanthogranulomas (XG) are benign proliferative disorder of histiocytes, a non-Langerhans cell histiocytosis. Whose etiology is unknown. The nature of these lesions is controversial and could be either reactive or neoplastic; the presence of monoclonal cells does, however, favor the second hypothesis. Xanthogranuloma is frequently found in young adults and children (under 20 years old), mainly in the skin. In about 5%-10% of all Juvenile XG (JXG) cases xanthogranuloma are extracutaneous. Within this group, the site most frequently involved is the eye. Other involved organs are heart, liver, adrenals, oropharynx, lung, spleen, central nervous system and subcutaneous tissue, although involvement of the spine is uncommon. Isolated lesions involving the sacral region are extremely rare. To date, this is the first reported case of a giant JXG arising from S1 with extension into the pelvic region in an adult spine.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150122
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.12998/wjcc.v3.i1.77

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[PMID]: 25610847
[Au] Autor:Goel AK
[Ad] Address:Ajay Kumar Goel, Biotechnology Division, Defence Research and Development Establishment, Gwalior 474002, India.
[Ti] Title:Anthrax: A disease of biowarfare and public health importance.
[So] Source:World J Clin Cases;3(1):20-33, 2015 Jan 16.
[Is] ISSN:2307-8960
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Bioterrorism has received a lot of attention in the first decade of this century. Biological agents are considered attractive weapons for bioterrorism as these are easy to obtain, comparatively inexpensive to produce and exhibit widespread fear and panic than the actual potential of physical damage. Bacillus anthracis (B. anthracis), the etiologic agent of anthrax is a Gram positive, spore forming, non-motile bacterium. This is supposed to be one of the most potent BW agents because its spores are extremely resistant to natural conditions and can survive for several decades in the environment. B. anthracis spores enter the body through skin lesion (cutaneous anthrax), lungs (pulmonary anthrax), or gastrointestinal route (gastrointestinal anthrax) and germinate, giving rise to the vegetative form. Anthrax is a concern of public health also in many countries where agriculture is the main source of income including India. Anthrax has been associated with human history for a very long time and regained its popularity after Sept 2001 incidence in United States. The present review article describes the history, biology, life cycle, pathogenicity, virulence, epidemiology and potential of B. anthracis as biological weapon.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150122
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.12998/wjcc.v3.i1.20

  8 / 604807 MEDLINE  
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[PMID]: 25610609
[Au] Autor:Brewis MJ; Church AC; Peacock AJ; Thomson S; Tighe J; Johnson MK
[Ad] Address:Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, United Kingdom....
[Ti] Title:Pulmonary hypertension in POEMS syndrome: resolution following radiotherapy.
[So] Source:Pulm Circ;4(4):732-5, 2014 Dec.
[Is] ISSN:2045-8932
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Pulmonary hypertension (PH) is defined by the presence of a mean pulmonary artery pressure (mPAP) ≥25 mmHg. It may be idiopathic or arise as a consequence of a number of diverse conditions. PH has been reported in association with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes), with reversal following systemic treatment with corticosteroids. We report a case of pulmonary hypertension associated with POEMS syndrome treated with radical radiotherapy locally to bone lesions with resolution of systemic disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150122
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1086/678553

  9 / 604807 MEDLINE  
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[PMID]: 25610361
[Au] Autor:Jakubowicz O; Luczkowska M; Zaba R; Adamski Z
[Ad] Address:Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Zygmunt Adamski....
[Ti] Title:Tinea cutis glabrae: causes of diagnostic challenge.
[So] Source:Postepy Dermatol Alergol;31(6):421-4, 2014 Dec.
[Is] ISSN:1642-395X
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Dermatophytoses belong to the most common disease entities encountered in everyday dermatological practice. Despite the fact that their clinical presentation, course and treatment response remain rather typical, they often present a considerable diagnostic and therapeutic challenge. We present a case of a 54-year-old male who presented to the outpatient clinic of the Department of Dermatology in December 2012 with the diagnosis of erythema gyratum repens for further diagnosis and treatment of skin lesions gradually intensifying in the previous 2 years. The skin changes presented as spreading annular erythematous lesions, with papules and plaques located peripherally, and accompanying pruritus. Due to the clinical presentation and anamnesis, working conditions (poultry farm), and lack of response to previous treatment, mycological culture was performed. Epithelial scrapings of the trunk and the groins proved to be positive. After 3 weeks, Trichophyton mentagrophytes var mentagrophytes was identified by epithelial cell culture.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150122
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5114/pdia.2014.40950

  10 / 604807 MEDLINE  
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[PMID]: 25610359
[Au] Autor:Lesiak A; Wlodarczyk M; Sobolewska A; Sieniawska J; Rogowski-Tylman M; Sysa-Jedrzejowska A; Olejniczak-Staruch I; Narbutt J
[Ad] Address:Department of Dermatology, Medical University of Lodz, Lodz, Poland. Head of the Department: Prof. Anna Sysa-Jedrzejowska MD, PhD....
[Ti] Title:Can biologic treatment induce cutaneous focal mucinosis?
[So] Source:Postepy Dermatol Alergol;31(6):413-6, 2014 Dec.
[Is] ISSN:1642-395X
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Skin mucinosis is a rare skin disease which clinically manifests as firm papules and waxy nodules. We report a case of a 66-year-old female psoriatic patient who developed skin mucinosis during biological therapy. Because of a previous lack of response to the local and conventional systemic treatment of psoriasis, the patient received biological therapy (infliximab from June 2008 to May 2009 - initial clinical improvement and loss of treatment effectiveness in the 36(th) week of the therapy; adalimumab from June 2009 to January 2010 - lack effectiveness; ustekinumab from March 2012 to the present). Throughout 2 months we observed a manifestation of the skin mucinosis as well-demarcated, yellow and brown, papulo-nodular lesions of 5-10 mm in diameter, localized on the back. Histopathological examination with alcian blue staining demonstrated mucin deposits in the dermis. On the basis of clinical and histopathological findings, the diagnosis of cutaneous focal mucinosis was established. We present the case because of the extremely rare occurrence of the disease. Scarce literature and data suggest that there is an association between focal mucinosis and thyroid dysfunction, as well as possible adverse effects of biological therapy with TNF-α antagonists.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Cu] Class update date: 150124
[Lr] Last revision date:150124
[Da] Date of entry for processing:150122
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5114/pdia.2014.40944


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