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[PMID]: 25041622
[Au] Autor:Rosa Ados S; Bandeira LG; Monte-Alto-Costa A; Romana-Souza B
[Ad] Address:Department of Animal Biology, Rural Federal University of Rio de Janeiro, Seropédica, Brazil.
[Ti] Title:Supplementation with olive oil, but not fish oil, improves cutaneous wound healing in stressed mice.
[So] Source:Wound Repair Regen;22(4):537-47, 2014 Jul.
[Is] ISSN:1524-475X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Supplementation with olive and fish oils reverses the effects of stress on behavioral activities and adrenal activation. However, previous studies have not shown whether supplementation with olive and fish oil could inhibit the effects of stress on cutaneous wound healing. Thus, this study investigated the effects of supplementation with fish or olive oil on cutaneous healing in stressed mice. Mice were subjected to rotational stress and treated with olive or fish oil daily until euthanasia. An excisional lesion was created on each mouse, and 14 days later, the lesions were analyzed. In addition, murine skin fibroblasts were exposed to elevated epinephrine levels plus olive oil, and fibroblast activity was evaluated. In the in vivo studies, administration of olive oil, but not fish oil, inhibited stress-induced reduction in wound contraction, reepithelialization, hydroxyproline levels, and blood vessel density. Stress-induced increases in vascular endothelial growth factor expression and the numbers of macrophages and neutrophils were reversed only by olive oil. Both oils reversed stress-induced increase in catecholamine levels and oxidative damage. In in vitro studies, olive oil treatment reversed the reduction in fibroblast migration and collagen deposition and the increase in lipid peroxidation induced by epinephrine. In conclusion, supplementation with olive oil, but not fish oil, improves cutaneous wound healing in chronically stressed mice.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/wrr.12191

  2 / 591827 MEDLINE  
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[PMID]: 24899251
[Au] Autor:Rashaan ZM; Krijnen P; Klamer RR; Schipper IB; Dekkers OM; Breederveld RS
[Ad] Address:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Burn Center, Red Cross Hospital Beverwijk, Beverwijk, The Netherlands.
[Ti] Title:Nonsilver treatment vs. silver sulfadiazine in treatment of partial-thickness burn wounds in children: A systematic review and meta-analysis.
[So] Source:Wound Repair Regen;22(4):473-82, 2014 Jul.
[Is] ISSN:1524-475X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The evidence for application of silver-containing dressings and topicals in the treatment of partial-thickness burns in pediatric patients is largely based on clinical trials involving adult patients despite the important differences between the skin of children and adults. A systematic review and meta-analysis was performed of all randomized controlled trials comparing nonsilver treatment with silver-containing dressings and silver topical agents in children with partial-thickness burns in the acute stage. Endpoints were wound healing, grafting, infection, pain, number of dressing changes, length of hospital stay, and scarring. Seven randomized controlled trials were included involving 473 participants. All trials used silver sulfadiazine as control in comparison with five different nonsilver treatments. Most trials were of moderate quality with high risk of bias. Use of nonsilver treatment led to shorter wound healing time (weighted mean difference: -3.43 days, 95% confidence interval: -4.78, -2.07), less dressing changes (weighted mean difference: -19.89 dressing changes, 95% confidence interval: -38.12, -1.66), and shorter length of hospital stay (weighted mean difference: -2.07 days, 95% confidence interval: -2.63, -1.50) compared with silver sulfadiazine treatment, but no difference in the incidence of wound infection or grafting was found. In conclusion, nonsilver treatment may be preferred over silver sulfadiazine, but high-quality randomized controlled trials are needed to validly confirm the effectiveness of silver containing preparations, in particular silver-containing dressings, above nonsilver treatments.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/wrr.12196

  3 / 591827 MEDLINE  
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[PMID]: 24899130
[Au] Autor:Mittal A; Kumar N
[Ad] Address:Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India.
[Ti] Title:A new, bioactive, antibacterial-eluting, composite graft for infection-free wound healing.
[So] Source:Wound Repair Regen;22(4):527-36, 2014 Jul.
[Is] ISSN:1524-475X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The current work focuses on the in vivo performance of a newly developed injectable composite graft in infected full-thickness wounds. The composite graft was composed of bioactive porous Poly dl-lactide-co-glycolide scaffolds, antibiotic gentamicin, and crosslinked gelatin as carrier gel. Treated infected wounds exhibited a faster wound closure, rapid weight gain, lower neutrophil count, higher breaking strength, and 100 times lesser microbial count (10(2) colony forming units/g in infected treated vs. 10(4) colony forming units/g in infected control group) in comparison with infected control group 28 days post treatment. During healing, collagen production was more in the treated groups at day 7 than controls and thereafter gradually reduced to normal levels. Histology revealed a mature scar tissue formation, fibroblast proliferation, epidermal resurfacing, and collagen deposition in reticular alignment similar to normal healthy skin in treated wounds. Further, the plasma concentration of gentamicin was 35-45 µg/mL during the initial 12 hours and reduced to 1 µg/mL in 24 hours, which indicated safe levels of the antibiotic drug during healing. These results clearly indicate a faster, infection-free, and safe after treatment with the developed graft.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/wrr.12194

  4 / 591827 MEDLINE  
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[PMID]: 24898050
[Au] Autor:Caskey RC; Zgheib C; Morris M; Allukian M; Dorsett-Martin W; Xu J; Wu W; Liechty KW
[Ad] Address:Department of General Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
[Ti] Title:Dysregulation of collagen production in diabetes following recurrent skin injury: Contribution to the development of a chronic wound.
[So] Source:Wound Repair Regen;22(4):515-20, 2014 Jul.
[Is] ISSN:1524-475X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Recurrent injury has been implicated in the development of chronic diabetic wounds. We have developed a chronic diabetic wound model based upon recurrent injury in diabetic mice. We hypothesized that dysregulation of collagen production at both the mRNA and microRNA levels contributes to the development of chronic diabetic wounds. To test this, both diabetic and nondiabetic mice were made to undergo recurrent injury. Real-time PCR for TGF-ß1, SMAD-3, Col1α1, Col3α1, microRNA-25, and microRNA-29a and Western blot for collagen I and III were performed 7 days following each injury. Diabetic wounds displayed decreased collagen at all time points. This was associated with dysregulated collagen production at both the gene and microRNA levels at all time points. Following the final injury, however, diabetic collagen production significantly improved. This appeared to be due to a substantial decrease in both microRNAs as well as an increase in the expression of collagen pathway genes. That dysregulated collagen production progressed throughout the course of wounding suggests that this is one factor contributing to the development of chronic diabetic wounds. Future studies using this model will allow for the determination of other factors that may also contribute to the development and/or persistence of chronic diabetic wounds.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/wrr.12199

  5 / 591827 MEDLINE  
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[PMID]: 24617837
[Au] Autor:Rubio-Martínez LM; Hendrickson DA; Stetter M; Zuba JR; Marais HJ
[Ad] Address:Department of Companion Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
[Ti] Title:Laparoscopic Vasectomy in African Elephants (Loxodonta africana).
[So] Source:Vet Surg;43(5):507-14, 2014 Jul.
[Is] ISSN:1532-950X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To describe a surgical technique for, and outcome after, laparoscopic vasectomy of free-ranging elephants. STUDY DESIGN: Case series. ANIMALS: African elephants (Loxodonta africana; n = 14). METHODS: Male elephants (12-35 years old) were anesthetized with etorphine and supported in a sling in a modified standing position, and positive pressure ventilated with oxygen. Anesthesia was maintained with IV etorphine. Vasectomy was performed under field conditions by bilateral, open-approach, flank laparoscopy with the abdomen insufflated with filtered ambient air. A 4-cm segment of each ductus deferens was excised. Behavior and incision healing were recorded for 8 months postoperatively. RESULTS: Successful bilateral vasectomy (surgical time, 57-125 minutes) was confirmed by histologic examination of excised tissue. Recovery was uneventful without signs of abnormal behavior. Large intestine lacerations (3 elephants; 1 full and 2 partial thickness) were sutured extracorporeally. One elephant found dead at 6 weeks, had no prior abnormal signs. Skin incisions healed without complication. CONCLUSIONS: Laparoscopic vasectomy can be performed in African elephants in their natural environment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/j.1532-950X.2014.12163.x

  6 / 591827 MEDLINE  
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[PMID]: 24740884
[Au] Autor:Mitchell R; Szabo E; Shapovalova Z; Aslostovar L; Makondo K; Bhatia M
[Ad] Address:Stem Cell and Cancer Research Institute; Department of Biochemistry and Biomedical Sciences, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada.
[Ti] Title:Molecular Evidence for OCT4-Induced Plasticity in Adult Human Fibroblasts Required for Direct Cell Fate Conversion to Lineage Specific Progenitors.
[So] Source:Stem Cells;32(8):2178-87, 2014 Aug.
[Is] ISSN:1549-4918
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Here we characterize the molecular and biological requirements for OCT4 plasticity induction in human skin derived fibroblasts (hFibs) that allows direct conversion of cell fate without iPSC formation. Our results indicate that adult hFibs not only require OCT4 but also short-term exposure to reprogramming media (RM) to successfully undergo direct conversion to early hematopoietic and neural progenitor fates. RM was found to be essential in this process and allowed for unique changes in global gene expression specific to the combined effects of OCT4 and treatment with reprogramming media to establish a plastic state. This molecular state of hFib plasticity was distinct from transient expression of a full complement of iPSC reprogramming factors consistent with a lack in molecular hallmarks of iPSC formation. Human Fib-derived OCT4 plastic cells display elevated levels of developmentally related genes associated with multiple lineages, but not those associated with pluripotency. In response to changes in the extracellular environment, plastic OCT4-expressing hFibs further activate genes involved in hematopoietic as well as tripotent neural progenitor biology that allow cell fate conversion. Our study provides a working definition of hFib-induced plasticity using OCT4 and a deconvoluted system to elucidate the process of direct cell fate reprogramming. Stem Cells 2014;32:2178-2187.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1002/stem.1721

  7 / 591827 MEDLINE  
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[PMID]: 24585677
[Au] Autor:De Kock J; Meuleman P; Raicevic G; Rodrigues RM; Branson S; Meganathan K; De Boe V; Sachinidis A; Leroux-Roels G; Vanhaecke T; Lagneaux L; Rogiers V; Najar M
[Ad] Address:Department of In Vitro Toxicology and Dermato-Cosmetology, Center for Pharmaceutical Research, Vrije Universiteit Brussel, Brussels, Belgium.
[Ti] Title:Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response.
[So] Source:Stem Cells;32(8):2215-28, 2014 Aug.
[Is] ISSN:1549-4918
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Human skin-derived precursors (hSKPs) are multipotent somatic stem cells that persist within the dermis throughout adulthood and harbor potential clinical applicability. In this study, we investigated their immunogenicity and immunosuppressive features, both in vitro and in vivo. As such, this study provides a solid basis for developing their future clinical applications. We found that hSKPs express HLA-ABC molecules, but not HLA-DR, rendering them poorly immunogenic. Using a coculture set-up, we could further demonstrate that hSKPs inhibit the proliferation of allogeneic activated T cells and alter their cytokine secretion profile, in a dose-dependent manner. Cotransplantation of hSKP and human peripheral blood leukocytes (PBL) into severe combined immune-deficient mice also showed a significant impairment of the graft-versus-host response 1 week post-transplantation and a drastic increase in survival time of 60%. From a mechanistic point of view, we found that hSKPs require cell contact as well as secretion of soluble inhibitory factors in order to modulate the immune response. The expression/secretion levels of these factors further increases upon inflammation or in the presence of activated T cells. As such, we believe that these features could be beneficial in a later allogeneic clinical setting, because rejection of engrafted allogeneic hSKP might be delayed or even avoided due to their own promotion of a tolerogenic microenvironment. Stem Cells 2014;32:2215-2228.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1002/stem.1692

  8 / 591827 MEDLINE  
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[PMID]: 24661038
[Au] Autor:Tsugita T; Kimura R; Iwai T
[Ad] Address:Skin Care Products Research, Kao Corporation, Tokyo, Japan; Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
[Ti] Title:Spectroscopic study on appearances of make-up skins using a visible RGB-LED OCT.
[So] Source:Skin Res Technol;20(3):379-84, 2014 Aug.
[Is] ISSN:1600-0846
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND/PURPOSE: Facial foundation is very effective to correct color irregularities of the skin surface and to protect the skin from harmful light. This depends strongly on both the optical properties and the coating condition of foundation on the skin surface. METHODS: We constructed the full-field optical coherence tomography (OCT) (FF-OCT) microscope with visible light sources of RGB LEDs. The commercially available skin replicas were used as the model of skin in the experiment, which were composed of two layers, a thin polyurethane film transcribed from cheek surface of a female and a beige-colored silicone substrate. The foundations were applied to the skin replicas under the constant pressure. RESULTS: A topographic image provides spectroscopic information of reflected light and effectiveness of correction of surface irregularities by applying the foundation. A tomographic image demonstrates the spectroscopic degree of light penetration into the skin tissue. It is shown that the reflectivity increases consistently with thickness of the applied foundation because light reflected from the surface and diffusively reflected from the inside of the tissue increases as the surface becomes flat applying the foundation. CONCLUSION: We confirmed experimentally the potential of the spectroscopic FF-OCT microscopy in investigating both qualitatively and quantitatively the effectiveness of facial foundation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/srt.12130

  9 / 591827 MEDLINE  
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[PMID]: 24628680
[Au] Autor:Anderson KR; Oleson JJ; Anthony TR
[Ad] Address:Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USA.
[Ti] Title:Variability in coefficient of restitution in human facial skin.
[So] Source:Skin Res Technol;20(3):355-62, 2014 Aug.
[Is] ISSN:1600-0846
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: If particles rebound on human facial skin, they can be re-entrained into the airflow and subsequently inhaled, increasing aspiration efficiency estimates. A realistic estimate of facial skin coefficient of restitution (CoR) is necessary to accurately model particle bounce. This study investigated the effects of sampling location, temperature, humidity levels, age, gender, and BMI on facial skin CoR. METHODS: A torsional ballistometer was used to measure facial CoR for 30 participants divided into three age groups (18-30, 31-40, and 41-65 years), at three temperatures and three humidity levels. The study was repeated twice: once in the late winter and once in the early summer to capture the seasonal variability. RESULTS: The CoR significantly varied across five facial locations, with values ranging from 0.55 to 0.75. Gender, sampling season and the interaction between sampling location and age were found to be significant, but changes in values were relatively small (0.05 at most) and are not considered practically significant. CONCLUSION: CoR was non-uniform across the face. The use of uniform CoR value as modeling input parameters or for mannequin facial surfaces in experimental wind tunnel studies may not be accurate due to the high variability in CoR between facial sampling locations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/srt.12126

  10 / 591827 MEDLINE  
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[PMID]: 24506277
[Au] Autor:Cinotti E; Gergelé L; Perrot JL; Dominé A; Labeille B; Borelli P; Cambazard F
[Ad] Address:Department of Dermatology, University Hospital of Saint Etienne, Saint-Etienne, France.
[Ti] Title:Quantification of capillary blood cell flow using reflectance confocal microscopy.
[So] Source:Skin Res Technol;20(3):373-8, 2014 Aug.
[Is] ISSN:1600-0846
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND/PURPOSE: In vivo reflectance confocal microscopy (IVCM) is a new tool for skin microcirculation. However, the measure of quantitative blood cell flow (QBCF) has not been standardized. We studied the inter-investigator and the intra-capillary reproducibility of the manual measure of QBCF on IVCM videos and investigated if a software program might help measure QBCF and be sensitive to vascular occlusion tests. METHODS: The inter-investigator reproducibility of the manual QBCF was evaluated on 107 videos. The intra-capillary reproducibility of QBCF measured manually and by 2 semi-automatic procedures based on Image J software analysis was evaluated on 19 capillaries. One of the semi-automatic methods (peaks of luminous intensity) was also used to measure the QBCF during vascular occlusion tests. RESULTS: The manual measure did not show a good inter-investigator reproducibility (Pearson's coefficient <0.5). The 'peaks of luminous intensity' method was found to have a good intra-capillary reproducibility and to be sensitive to vascular occlusion. CONCLUSION: Differently from the manual count, the count of peaks of luminous intensity by Image J software seems to be promising to measure QBCF. The future is to create software allowing for real-time measure of the QBCF based on the peaks of luminous intensity inside the capillaries recorded by IVCM.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1407
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/srt.12128


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