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[PMID]: 25690405
[Au] Autor:Zilliox LA; Ruby SK; Singh S; Zhan M; Russell JW
[Ad] Address:Department of Neurology, Maryland VA Healthcare System and University of Maryland, Baltimore, MD, USA....
[Ti] Title:Clinical neuropathy scales in neuropathy associated with impaired glucose tolerance.
[So] Source:J Diabetes Complications;29(3):372-7, 2015 Apr.
[Is] ISSN:1873-460X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:AIMS: Disagreement exists on effective and sensitive outcome measures in neuropathy associated with impaired glucose tolerance (IGT). Nerve conduction studies and skin biopsies are costly, invasive and may have their problems with reproducibility and clinical applicability. A clinical measure of neuropathy that has sufficient sensitivity and correlates to invasive measures would enable significant future research. METHODS: Data was collected prospectively on patients with IGT and symptomatic early neuropathy (neuropathy symptoms <2years) and normal controls. The seven scales that were examined were the Neuropathy Impairment Score of the Lower Limb (NIS-LL), Michigan Diabetic Neuropathy Score (MNDS), modified Toronto Clinical Neuropathy Scale (mTCNS), Total Neuropathy Score (Clinical) (TNSc), The Utah Early Neuropathy Scale (UENS), the Early Neuropathy Score (ENS), and the Neuropathy Disability Score (NDS). RESULTS: All seven clinical scales were determined to be excellent in discriminating between patients with neuropathy from controls without neuropathy. The strongest discrimination was seen with the mTCNS. The best sensitivity and specificity for the range of scores obtained, as determined by using receiver operating characteristic curves, was seen for the mTCNS followed by the TNSc. Most scales show a stronger correlation with measures of large rather than small fiber neuropathy. CONCLUSIONS: All seven scales identify patients with neuropathy. For the purpose of screening potential patients for a clinical study, the mTCNS followed by the TNSc would be most helpful to select patients with neuropathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 608764 MEDLINE  
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[PMID]: 25789299
[Au] Autor:Signorelli F; Anile C; Rigante M; Paludetti G; Pompucci A; Mangiola A
[Ad] Address:Francesco Signorelli, Carmelo Anile, Angelo Pompucci, Annunziato Mangiola, Department of Neurosurgery, Catholic University School of Medicine, 00168 Rome, Italy....
[Ti] Title:Endoscopic treatment of orbital tumors.
[So] Source:World J Clin Cases;3(3):270-4, 2015 Mar 16.
[Is] ISSN:2307-8960
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Different orbital and transcranial approaches are performed in order to manage orbital tumors, depending on the location and size of the lesion within the orbit. These approaches provide a satisfactory view of the superior and lateral aspects of the orbit and the optic canal but involve risks associated with their invasiveness because they require significant displacement of orbital structures. In addition, external approaches to intraconal lesions may also require deinsertion of extraocular muscles, with subsequent impact on extraocular mobility. Recently, minimally invasive techniques have been proposed as valid alternative to external approaches for selected orbital lesions. Among them, transnasal endoscopic approaches, "pure" or combined with external approaches, have been reported, especially for intraconal lesions located inferiorly and medially to the optic nerve. The avoidance of muscle detachment and the shortness of the surgical intraorbital trajectory makes endoscopic approach less invasive, thus minimizing tissue damage. Endoscopic surgery decreases the recovery time and improves the cosmetic outcome not requiring skin incisions. The purpose of this study is to review and discuss the current surgical techniques for orbital tumors removal, focusing on endoscopic approaches to the orbit and outlining the key anatomic principles to follow for safe tumor resection.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Da] Date of entry for processing:150319
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.12998/wjcc.v3.i3.270

  3 / 608764 MEDLINE  
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[PMID]: 25789297
[Au] Autor:Sharma GR; Maheshwari PN; Sharma AG; Maheshwari RP; Heda RS; Maheshwari SP
[Ad] Address:Gyanendra R Sharma, Department of Urology, Chitale Clinic Private Limited, Solapur, Maharashtra 413001, India....
[Ti] Title:Fluoroscopy guided percutaneous renal access in prone position.
[So] Source:World J Clin Cases;3(3):245-64, 2015 Mar 16.
[Is] ISSN:2307-8960
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Percutaneous nephrolithotomy is a very commonly done procedure for management of renal calculus disease. Establishing a good access is the first and probably the most crucial step of this procedure. A proper access is the gateway to success. However, this crucial step has the steepest learning curve for, in a fluoroscopy guided access, it involves visualizing a three dimensional anatomy on a two dimensional fluoroscopy screen. This review describes the anatomical basis of the renal access. It provides a literature review of all aspects of percutaneous renal access along with the advances that have taken place in this field over the years. The article describes a technique to determine the site of skin puncture, the angle and depth of puncture using a simple mathematical principle. It also reviews the common problems faced during the process of puncture and dilatation and describes the ways to overcome them. The aim of this article is to provide the reader a step by step guide for percutaneous renal access.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Da] Date of entry for processing:150319
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.12998/wjcc.v3.i3.245

  4 / 608764 MEDLINE  
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[PMID]: 25789120
[Au] Autor:Zomorodian K; Rahimi MJ; Taheri M; Ghanbari Asad A; Khani S; Ahrari I; Pakshir K; Khashei R
[Ad] Address:Basic Sciences in Infectious Diseases Research Center, Shiraz University Of Medical Sciences, Shiraz, IR Iran ; Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran....
[Ti] Title:The cutaneous bacterial microflora of the bodybuilders using anabolic-androgenic steroids.
[So] Source:Jundishapur J Microbiol;8(1):e12269, 2015 Jan.
[Is] ISSN:2008-3645
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:BACKGROUND: Anabolic-androgenic steroids (AAS) abuse by the athletes has dramatically increased during the recent decades. These substances might increase the skin lipids and enhance the cutaneous microbial proliferation. OBJECTIVES: The current study aimed to investigate the potential side effects of AAS on the bacterial microflora colonization of the bodybuilders` skin. PATIENTS AND METHODS: The skin samples of 94 male bodybuilders (71 AAS users, 23 non-AAS users) and 46 subjects of the control group, with similar gender and age, were cultured and incubated in both aerobic condition to isolate Staphylococcus aureus and anaerobic condition for Propionibacterium acnes. The isolated bacteria were identified by standard microbiological techniques. RESULTS: The skin lesions were more frequent in the body builders than the controls. Moreover, statistically significant differences were also observed in skin lesions among the AAS users and the non-AAS user athletes. The prevalence of S. aureus and P. acnes in the athletes was higher than that of the control group. In addition, there was a significant difference in distribution of P. acnes between the bodybuilders who used AAS and those who did not. CONCLUSIONS: A higher number of bacterial flora was found in the bodybuilders particularly those using AAS in comparison to the controls, which might be due to the influence of these AAS on the skin microflora and transmission of the bacteria through the direct contact of the naked skin with the exercise instruments.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Da] Date of entry for processing:150319
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5812/jjm.12269

  5 / 608764 MEDLINE  
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[PMID]: 25269719
[Au] Autor:Cheng Y; Sun Y; Wang H; Shi S; Yan Y; Li J; Ding C; Sun J
[Ad] Address:School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, China.
[Ti] Title:Cloning, expression and functional analysis of the duck Toll-like receptor 5 (TLR5) gene.
[So] Source:J Vet Sci;16(1):37-46, 2015 Mar.
[Is] ISSN:1976-555X
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in vertebrates. In the present study, the first TLR5 gene in duck was cloned. The open reading frame (ORF) of duck TLR5 (dTLR5) cDNA is 2580 bp and encodes a polypeptide of 859 amino acids. We also cloned partial sequences of myeloid differentiation factor 88, 2'-5'-oligoadenylate synthetase (OAS), and myxovirus resistance (Mx) genes from duck. dTLR5 mRNA was highly expressed in the bursa of Fabricius, spleen, trachea, lung, jejunum, rectum, and skin; moderately expressed in the muscular and glandular tissues, duodenum, ileum, caecum, and pancreas; and minimally expressed in the heart, liver, kidney, and muscle. DF-1 or HeLa cells transfected with DNA constructs encoding dTLR5 can activate NF-κB leading to the activation of interleukin-6 (IL-6) promoter. When we challenged ducks with a Herts33 Newcastle disease virus (NDV), mRNA transcription of the antiviral molecules Mx, Double stranded RNA activated protein kinase (PKR), and OAS was up-regulated in the liver, lung, and spleen 1 and 2 days post-inoculation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 608764 MEDLINE  
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[PMID]: 25269717
[Au] Autor:Tsioli V; Papazoglou LG; Papaioannou N; Psalla D; Savvas I; Pavlidis L; Karayannopoulpou M
[Ad] Address:Department of Surgery, Faculty of Veterinary Medicine, University of Thessaly, Karditsa 43100, Greece.vtsioli@vet.uth.gr.
[Ti] Title:Comparison of three skin-stretching devices for closing skin defects on the limbs of dogs.
[So] Source:J Vet Sci;16(1):99-106, 2015 Mar.
[Is] ISSN:1976-555X
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:Our objective was to evaluate the effectiveness of skin-stretching devices for closing defects on the extremities of dogs. Antebrachial skin defects were created on the limbs of 24 dogs randomly divided into three groups. Skin stretchers included staples and sutures passing through them (group A), sutures and hypodermic needles (group B), and Pavletic device (group C). Wounds on the left were further undermined in all groups. Tension and blood perfusion were assessed. After removing the stretchers on day 3, the defects were sutured and wound healing was clinically scored. Histological variables evaluated were cellular infiltration, edema, collagen orientation, and thickness of epidermis. Significant differences in tension were found among groups (p 0.0005) and between measurement times for undermined (p = 0.001) or non-undermined (p < 0.0005) wounds. In contrast, blood perfusion values did not differ significantly. Clinical scores for group B seemed to be better than those for groups A and C, but differences were not significant. Primary wound closure using the Pavletic device was not feasible. No significant differences in histological variables were found between groups. Skin stretching with staples or hypodermic needles resulted in successful wound management with minor side effects on skin histology and circulation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 608764 MEDLINE  
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[PMID]: 24962420
[Au] Autor:Kim JS; Rhim KJ; Jang WS; Lee SJ; Son Y; Lee SS; Park S; Lim SM
[Ad] Address:Research Center, Dongnam Institute of Radiological and Medical Sciences, Busan 619-953, Korea.jskim@dirams.re.kr.
[Ti] Title:ß-irradiation ((166)Ho patch)-induced skin injury in mini-pigs: effects on NF-κB and COX-2 expression in the skin.
[So] Source:J Vet Sci;16(1):1-9, 2015 Mar.
[Is] ISSN:1976-555X
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:In the present study, the detrimental effect of ß-emission on pig skin was evaluated. Skin injury was modeled in mini-pigs by exposing the animals to 50 and 100 Gy of ß-emission delivered by (166)Ho patches. Clinicopathological and immunohistochemical changes in exposed skin were monitored for 18 weeks after ß-irradiation. Radiation induced desquamation at 2˜4 weeks and gradual repair of this damage was evident 6 weeks after irradiation. Changes in basal cell density and skin depth corresponded to clinically relevant changes. Skin thickness began to decrease 1 week after irradiation, and the skin was thinnest 4 weeks after irradiation. Skin thickness increased transiently during recovery from irradiation-induced skin injury, which was evident 6˜8 weeks after irradiation. Epidermal expression of nuclear factor-kappa B (NF-κB) differed significantly between the untreated and irradiated areas. One week after irradiation, cyclooxygenase-2 (COX-2) expression was mostly limited to the basal cell layer and scattered among these cells. High levels of COX-2 expression were detected throughout the full depth of the skin 4 weeks after irradiation. These findings suggest that NF-κB and COX-2 play roles in epidermal cell regeneration following ß-irradiation of mini-pig skin.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review

  8 / 608764 MEDLINE  
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[PMID]: 25785950
[Au] Autor:Gilchrest BA; Campisi J; Chang HY; Fisher GJ; Kulesz-Martin MF
[Ad] Address:Dermatology Service, Massachusetts General Hospital, Boston, Massachusetts, USA....
[Ti] Title:Montagna symposium 2014-skin aging: molecular mechanisms and tissue consequences.
[So] Source:J Invest Dermatol;135(4):950-3, 2015 Apr.
[Is] ISSN:1523-1747
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1038/jid.2014.546

  9 / 608764 MEDLINE  
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[PMID]: 25785948
[Au] Autor:Katiyar SK
[Ad] Address:1] Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA [2] Department of Dermatology, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA.
[Ti] Title:Hsp90 Inhibitor Can Inhibit UV Carcinogenesis.
[So] Source:J Invest Dermatol;135(4):945-7, 2015 Apr.
[Is] ISSN:1523-1747
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Extensive exposure to solar UVR is a well-recognized etiologic factor for cutaneous non-melanoma skin cancer. In this issue of the Journal, Singh et al. show that topical treatment of the skin with 17-[allylamino]-17-demethoxygeldanamycin (17AAG), a heat-shock protein 90 (Hsp90) inhibitor, prevents UVR-induced squamous cell carcinomas (SCCs) in mice. The inhibitory effect of 17AAG on SCC was associated with the inhibition of the UVR-induced (i) hyperplastic response, (ii) Hsp90ß-PKCɛ interaction, and (iii) pStat3 and pAkt expression in mouse skin.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1038/jid.2014.504

  10 / 608764 MEDLINE  
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[PMID]: 25521459
[Au] Autor:Agarwal P; Rashighi M; Essien KI; Richmond JM; Randall L; Pazoki-Toroudi H; Hunter CA; Harris JE
[Ad] Address:Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA....
[Ti] Title:Simvastatin prevents and reverses depigmentation in a mouse model of vitiligo.
[So] Source:J Invest Dermatol;135(4):1080-8, 2015 Apr.
[Is] ISSN:1523-1747
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Vitiligo is a common autoimmune disease of the skin that results in disfiguring white spots. There are no Food and Drug Administration (FDA)-approved treatments, and current treatments are time-consuming, expensive, and of low efficacy. We sought to identify new treatments for vitiligo, and first considered repurposed medications because of the availability of safety data and expedited regulatory approval. We previously reported that the IFN-γ-induced chemokine CXCL10 is expressed in lesional skin from vitiligo patients, and that it is critical for the progression and maintenance of depigmentation in our mouse model of vitiligo. We hypothesized that targeting IFN-γ signaling might be an effective new treatment strategy. Activation of signal transducer and activator of transcription 1 (STAT1) is required for IFN-γ signaling and recent studies revealed that simvastatin, an FDA-approved cholesterol-lowering medication, inhibited STAT1 activation in vitro. Therefore, we hypothesized that simvastatin may be an effective treatment for vitiligo. We found that simvastatin both prevented and reversed depigmentation in our mouse model of vitiligo, and reduced the number of infiltrating autoreactive CD8(+) T cells in the skin. Treatment of melanocyte-specific, CD8(+) T cells in vitro decreased proliferation and IFN-γ production, suggesting additional effects of simvastatin directly on T cells. Based on these data, simvastatin may be a safe, targeted treatment option for patients with vitiligo.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150321
[Lr] Last revision date:150321
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1038/jid.2014.529


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