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[PMID]: 29513995
[Au] Autor:Dey A; Sandre V; Marangoni DG; Ghosh S
[Ti] Title:The Interaction Between a Non-Steroidal Anti-Inflammatory Drug (Ibuprofen) and Anionic Surfactant AOT and Effect of Salt (NaI) and Hydrotrope (4-4-4).
[So] Source:J Phys Chem B;, 2018 Mar 07.
[Is] ISSN:1520-5207
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Ibuprofen (IBF), 2-(4-isobutylphenyl) propionic acid, is a surface active, common non-steroidal anti-inflammatory drug (NSAID); IBF possesses a high critical micelle concentration (cmc) when compared to conventional surfactants. The interactions of this common NSAID with an anionic surfactant, sodium octyl sulfosuccinate (AOT) were studied bytensiometric, fluorimetric, and calorimetric measurementsin order to investigate this system as a possible model drug delivery system for an NSAID like IBF, particularly in a high dose regime for IBF. The interactions between the drug and the surfactant were modelled using a regular solution theory approach in the presence and absence of a model electrolyte (sodium iodide) and a novel nonaromatic, gemini hydrotrope, tetramethylene-1,4-bis(N,N-dimethyl-N-butylammonium bromide (4-4-4). Both the simple and the hydrotropic electrolyte were shown to have an effect on the solution properties (aggregation parameters, interfacial properties, and thermodynamics of aggregate formation) of the drug-surfactant mixtures, and on the interaction between the drug and the surfactant. Surface charges of all self-assembled systems were estimated from ζ-potential measurements; while density functional theory (DFT) calculations showed the interaction energy comparison among all the binary and ternary combinations. All these results were interpreted in terms of how altering the subtle balance of hydrophobic and electrostatic forces can significantly improve the ability of these self-assembled systems to transport drug molecules.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1021/acs.jpcb.8b00687

  2 / 19351 MEDLINE  
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[PMID]: 29436588
[Au] Autor:Li K; Li Y; Mi J; Mao L; Han X; Zhao J
[Ad] Address:Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.
[Ti] Title:Resveratrol protects against sodium nitroprusside induced nucleus pulposus cell apoptosis by scavenging ROS.
[So] Source:Int J Mol Med;41(5):2485-2492, 2018 May.
[Is] ISSN:1791-244X
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Oxidative stress induced disc cell apoptosis plays an important role in intervertebral disc (IVD) degeneration. The present study aims to investigate effects of resveratrol (RV), a natural polyphenol compound, on sodium nitroprusside (SNP) induced nucleus pulposus (NP) cell apoptosis and related mechanism. Rat NP cells were pretreated with RV, N-acetyl cysteine (NAC) and carboxy-PTIO (PTIO) before SNP treatment. Cell Counting Kit-8 assay was carried out for cell viability evaluation. Annexin V/propidium iodide (PI), Hoechst 33258 and Actin­Tracker Green and Tubulin-Tracker Red staining were conducted to detect NP cell apoptosis and apoptotic structural changes. Mitochondrial membrane potential (ΔΨm) was analyzed with tetramethylrhodamine methyl ester staining. DCFH-DA and DAF-FM DA staining was used to determine intracellular reactive oxygen species (ROS) and nitric oxide (NO) levels. An ex vivo experiment was also carried out followed by TUNEL assay of sections of discs. SNP induced NP cell apoptosis, excessive production of intracellular ROS and NO, reduction of ΔΨm as well as disruption of cytoskeletal and morphological structure. Meanwhile, organ culture results showed that SNP induced NP cell apoptosis ex vivo. RV and NAC siginificantly inhibited SNP induced NP cell apoptosis, production of intracellular ROS, deline of ΔΨm as well as disruption of cytoskeletal and morphological structure, while RV did not suppress NO production. RV and NAC could also suppress SNP induced NP cell apoptosis ex vivo. However, PTIO did not prevent SNP induced NP cell apoptosis, though it scavenged NO significantly. In conclusion, RV protects against SNP induced NP cell apoptosis by scavenging ROS but not NO, suggesting a promising prospect of RV in IVD degeneration retardation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.3892/ijmm.2018.3461

  3 / 19351 MEDLINE  
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[PMID]: 29507327
[Au] Autor:Yang J; Yi N; Zhang J; He W; He D; Wu W; Xu S; Li F; Fan G; Zhu X; Xue Z; Zhou W
[Ad] Address:Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China.
[Ti] Title:Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor.
[So] Source:Sci Rep;8(1):4004, 2018 Mar 05.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Thyroid stimulating hormone receptor (TSHR), a G-protein-coupled receptor, is important for thyroid development and growth. In several cases, frameshift and/or nonsense mutations in TSHR were found in the patients with congenital hypothyroidism (CH), however they have not been functionally studied in an animal model. In the present work, we generated a unique Tshr rat model that recapitulates the phenotypes in TSHR Y444X patient by CRISPR/Cas genome editing technology. In this rat model, TSHR is truncated at the second transmembrane domain, leading to CH phenotypes as what was observed in the patients, including dwarf, thyroid aplasia, infertility, TSH resistant as well as low serum thyroid hormone levels. The phenotypes can be reversed, at least partially, by levothyroxine (L-T4) treatment after weaning. The thyroid development is severely impaired in the Tshr rats due to the suppression of the thyroid specific genes, i.e., thyroperoxidase (Tpo), thyroglobulin (Tg) and sodium iodide symporter (Nis), at both mRNA and protein levels. In conclusion, the Tshr rat serves as a brand new genetic model to study CH in human, and will greatly help to shed light into the development of terminal organs that are sensitive to thyroid hormones.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-22405-7

  4 / 19351 MEDLINE  
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[PMID]: 29342216
[Au] Autor:Narayanaswamy VP; Giatpaiboon SA; Uhrig J; Orwin P; Wiesmann W; Baker SM; Townsend SM
[Ad] Address:Synedgen, Inc., Claremont, California, United States of America.
[Ti] Title:In Vitro activity of novel glycopolymer against clinical isolates of multidrug-resistant Staphylococcus aureus.
[So] Source:PLoS One;13(1):e0191522, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The incidence of multidrug-resistant (MDR) organisms, including methicillin-resistant Staphylococcus aureus (MRSA), is a serious threat to public health. Progress in developing new therapeutics is being outpaced by antibiotic resistance development, and alternative agents that rapidly permeabilize bacteria hold tremendous potential for treating MDR infections. A new class of glycopolymers includes polycationic poly-N (acetyl, arginyl) glucosamine (PAAG) is under development as an alternative to traditional antibiotic strategies to treat MRSA infections. This study demonstrates the antibacterial activity of PAAG against clinical isolates of methicillin and mupirocin-resistant Staphylococcus aureus. Multidrug-resistant S. aureus was rapidly killed by PAAG, which completely eradicated 88% (15/17) of all tested strains (6-log reduction in CFU) in ≤ 12-hours at doses that are non-toxic to mammalian cells. PAAG also sensitized all the clinical MRSA strains (17/17) to oxacillin as demonstrated by the observed reduction in the oxacillin MIC to below the antibiotic resistance breakpoint. The effect of PAAG and standard antibiotics including vancomycin, oxacillin, mupirocin and bacitracin on MRSA permeability was studied by measuring propidium iodide (PI) uptake by bacterial cells. Antimicrobial resistance studies showed that S. aureus developed resistance to PAAG at a rate slower than to mupirocin but similar to bacitracin. PAAG was observed to resensitize drug-resistant S. aureus strains sampled from passage 13 and 20 of the multi-passage resistance study, reducing MICs of mupirocin and bacitracin below their clinical sensitivity breakpoints. This class of bacterial permeabilizing glycopolymers may provide a new tool in the battle against multidrug-resistant bacteria.
[Mh] MeSH terms primary: Anti-Bacterial Agents/pharmacology
Glucosamine/analogs & derivatives
Methicillin-Resistant Staphylococcus aureus/drug effects
Polymers/pharmacology
Polysaccharides/pharmacology
[Mh] MeSH terms secundary: Anti-Bacterial Agents/chemistry
Drug Resistance, Multiple, Bacterial
Glucosamine/chemistry
Glucosamine/pharmacology
Glycosides
Humans
In Vitro Techniques
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus/isolation & purification
Methicillin-Resistant Staphylococcus aureus/metabolism
Microbial Sensitivity Tests
Mupirocin/pharmacology
Permeability/drug effects
Polymers/chemistry
Polysaccharides/chemistry
Propidium/pharmacokinetics
Staphylococcal Infections/drug therapy
Staphylococcal Infections/microbiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Glycosides); 0 (Polymers); 0 (Polysaccharides); 0 (pinocembrin 7-O-apiosyl(1-5)apiosyl(1-2)glucopyranoside); 0 (poly-N (acetyl, arginyl)glucosamine); 36015-30-2 (Propidium); D0GX863OA5 (Mupirocin); N08U5BOQ1K (Glucosamine)
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[Js] Journal subset:IM
[Da] Date of entry for processing:180118
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191522

  5 / 19351 MEDLINE  
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[PMID]: 29495389
[Au] Autor:Kotlarek M; Kubiak A; Czetwertynska M; Swierniak M; Gierlikowski W; Kolanowska M; Bakula-Zalewska E; Jhiang SM; Jazdzewski K; Wójcicka A
[Ad] Address:Genomic Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland. mkotlarek@wum.edu.pl.
[Ti] Title:The rs2910164 Genetic Variant of miR-146a-3p Is Associated with Increased Overall Mortality in Patients with Follicular Variant Papillary Thyroid Carcinoma.
[So] Source:Int J Mol Sci;19(3), 2018 Feb 26.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Aberrant expression of the sodium-iodide symporter (NIS) and the resistance to post-operative radioactive iodide treatment is a crucial cause of higher mortality of some thyroid cancer patients. In this study, we analyzed the impact of miR-146a on the expression and function of NIS and on the overall survival of thyroid cancer patients. The study included 2441 patients (2163 women; 278 men); including 359 cases with follicular variant of papillary thyroid carcinoma (fvPTC). miR: interactions were analyzed in cell lines using in vivo binding and inhibition assays and radioactive iodine uptake assays. Tumor/blood DNA was used for rs2910164 genotyping. Overall survival was assessed retrospectively. In the results, we showed that miR-146a-3p directly binds to and inhibits . Inhibition of miR-146a-3p restores the expression and function of increasing radioactive iodine uptake. Rs2910164 functional variant within miR-146a-3p is associated with increased overall mortality among fvPTC female patients. The deaths per 1000 person-years were 29.7 in CC carriers vs. 5.08 in GG/GC-carriers (HR = 6.21, ). Higher mortality of CC vs. GG/GC carriers was also observed in patients with lower clinical stage (HR = 22.72, < 0.001), smaller tumor size (pT1/pT2) (HR = 25.05, ), lack of extrathyroidal invasion (HR = 9.03, = 0.02), lack of nodular invasion (HR = 7.84, ), lack of metastases (HR = 6.5, = 0.005) and older (age at diagnosis >50 years) (HR = 7.8, ). MiR-146a-3p underwent somatic mutations in 16.1% of analyzed specimens, mainly towards the deleterious C allele. In this report we propose a novel molecular marker of the clinical outcome of fvPTC patients. Rs2910164 increases the overall mortality with inhibition of NIS and disruption of radioiodine uptake as a possible mechanism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  6 / 19351 MEDLINE  
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[PMID]: 29460068
[Au] Autor:Isaac-Márquez AP; Talamás-Rohana P; Galindo-Sevilla N; Gaitan-Puch SE; Díaz-Díaz NA; Hernández-Ballina GA; Lezama-Dávila CM
[Ad] Address:Centro de Investigaciones Biomédicas, Universidad Autónoma de Campeche, Av. Patricio Trueba de Regil s/n, Col. Lindavista, C.P. 24090, San Francisco de Campeche, Camp, Mexico. anpisaac@hotmail.com.
[Ti] Title:Decanethiol functionalized silver nanoparticles are new powerful leishmanicidals in vitro.
[So] Source:World J Microbiol Biotechnol;34(3):38, 2018 Feb 19.
[Is] ISSN:1573-0972
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:We evaluated, for the first time, the leishmanicidal potential of decanethiol functionalized silver nanoparticles (AgNps-SCH) on promastigotes and amastigotes of different strains and species of Leishmania: L. mexicana and L. major isolated from different patients suffering from localized cutaneous leishmaniasis (CL) and L. mexicana isolated from a patient suffering from diffuse cutaneous leishmaniasis (DCL). We recorded the kinetics of promastigote growth by daily parasite counting for 5 days, promastigote mobility, parasite reproduction by CFSE staining's protocol and promastigote killing using the propidium iodide assay. We also recorded IC 's of promastigotes and amastigotes, therapeutic index, and cytotoxicity by co-culturing macrophages with AgNps-SCH or sodium stibogluconate (Sb) used as reference drug. We used Sb as a reference drug since it is used as the first line treatment for all different types of leishmaniasis. At concentrations 10,000 times lower than those used with Sb, AgNps-SCH had a remarkable leishmanicidal effect in all tested strains of parasites and there was no toxicity to J774A.1 macrophages since > 85% were viable at the concentrations used. Therapeutic index was about 20,000 fold greater than the corresponding one for Sb treated cells. AgNps-SCH inhibited > 80% promastigote proliferation in all tested parasites. These results demonstrate there is a high leishmanicidal potential of AgNps-SCH at concentrations of 0.04 µM. Although more studies are needed, including in vivo testing of AgNps-SCH against different types of leishmaniasis, they can be considered a potential new treatment alternative.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process
[do] DOI:10.1007/s11274-018-2420-0

  7 / 19351 MEDLINE  
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[PMID]: 29437784
[Au] Autor:De la Vieja A; Santisteban P
[Ad] Address:Tumor Endocrine UnitChronic Disease Program (UFIEC), Instituto de Salud Carlos III, Madrid, Spain adelavieja@isciii.es.
[Ti] Title:Role of iodide metabolism in physiology and cancer.
[So] Source:Endocr Relat Cancer;25(4):R225-R245, 2018 Apr.
[Is] ISSN:1479-6821
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Iodide (I ) metabolism is crucial for the synthesis of thyroid hormones (THs) in the thyroid and the subsequent action of these hormones in the organism. I is principally transported by the sodium iodide symporter (NIS) and by the anion exchanger PENDRIN, and recent studies have demonstrated the direct participation of new transporters including anoctamin 1 (ANO1), cystic fibrosis transmembrane conductance regulator (CFTR) and sodium multivitamin transporter (SMVT). Several of these transporters have been found expressed in various tissues, implicating them in I recycling. New research supports the exciting idea that I participates as a protective antioxidant and can be oxidized to hypoiodite, a potent oxidant involved in the host defense against microorganisms. This was possibly the original role of I in biological systems, before the appearance of TH in evolution. I per se participates in its own regulation, and new evidence indicates that it may be antineoplastic, anti-proliferative and cytotoxic in human cancer. Alterations in the expression of I transporters are associated with tumor development in a cancer-type-dependent manner and, accordingly, NIS, CFTR and ANO1 have been proposed as tumor markers. Radioactive iodide has been the mainstay adjuvant treatment for thyroid cancer for the last seven decades by virtue of its active transport by NIS. The rapid advancement of techniques that detect radioisotopes, in particular I , has made NIS a preferred target-specific theranostic agent.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Data-Review
[do] DOI:10.1530/ERC-17-0515

  8 / 19351 MEDLINE  
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[PMID]: 29464362
[Au] Autor:Yadav AK; Sirohi P; Saraswat S; Rani M; Singh MP; Srivastava S; Singh NK
[Ad] Address:Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, U.P., 211004, India.
[Ti] Title:Inhibitory Mechanism on Combination of Phytic Acid with Methanolic Seed Extract of Syzygium cumini and Sodium Chloride over Bacillus subtilis.
[So] Source:Curr Microbiol;, 2018 Feb 20.
[Is] ISSN:1432-0991
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The antibiotic resistance in bacteria responsible for causing community and health care-associated infection displayed a major threat to global health. Use of broad-spectrum antibiotics for the treatment of various ailments poses serious side effects. In the present research, we investigated the combined role of 2% phytic acid with 2% methanolic seed extract of Syzygium cumini and 0.5% sodium chloride for inhibition of Bacillus subtilis and Pseudomonas aeruginosa and found it to be efficient over B. subtilis. The zone of inhibition by present mixture was found to be 2.9 ± 0.0004 and 1.9 ± 0.0006 cm against Bacillus subtilis and P. aeruginosa in comparison to individual component. Mixture was found more potent against B. subtilis and selected for further study. The underlying mechanism involved in inhibitory action of this mixture was determined by Scanning electron microscope, DNA fragmentation and propidium iodide staining. Scanning electron microscopy revealed that inhibition of B. subtilis by this mixture is mainly due to the disruption of bacterial cell membrane, leakage of internal cellular content which ultimately leads to the death of bacterial cells. DNA fragmentation showed apoptotic hallmark through degradation caused by mixture against B. subtilis at various time intervals. Likewise, PI staining also revealed the disruption of bacterial membrane by the mixture as the PI gives fluorescence after binding with DNA. The present study concludes that inhibitory potential of this mixture is mainly due to disruption of bacterial cell membrane, degradation of DNA and creation of pores in the membrane. The mixture could be used for inhibition of food pathogen B. subtilis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:Publisher
[do] DOI:10.1007/s00284-018-1457-5

  9 / 19351 MEDLINE  
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[PMID]: 29376775
[Au] Autor:Sarker M; Izadifar M; Schreyer D; Chen X
[Ad] Address:a Division of Biomedical Engineering, College of Engineering , University of Saskatchewan , Saskatoon , Canada.
[Ti] Title:Influence of ionic crosslinkers (Ca /Ba /Zn ) on the mechanical and biological properties of 3D Bioplotted Hydrogel Scaffolds.
[So] Source:J Biomater Sci Polym Ed;:1-29, 2018 Feb 21.
[Is] ISSN:1568-5624
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Three dimensional (3D) bioplotting requires appropriate crosslinkers to crosslink the hydrogel precursor while simultaneously maintaining the viability of embedded cells. However, the evaluation and comparison of various types of crosslinkers in bioplotting remains underexplored to date. This paper presents our study of the influence of three ionic crosslinkers-calcium chloride (CaCl ), barium chloride (BaCl ), and zinc chloride (ZnCl )-on the mechanical and biological properties of 3D bioplotted alginate scaffolds. The scaffold mechanical properties characterized included the elastic modulus, swelling, and degradation while the biological properties considered included Schwann cell viability and surface morphology. The mechanical and biological properties of the bioplotted scaffolds were both dependent on the crosslinkers used for fabrication; specifically, crosslinking ions resulted in the elastic modulus of the hydrogels decreasing in the order BaCl >CaCl >ZnCl over 42 days while Schwann cell viability decreased in the order CaCl >BaCl >ZnCl over 7 days. Taken together, these results offer insights that are effective in terms of manipulating the 3D bioplotting process so as to tune and optimize the mechanical and biological performance of the plotted scaffolds for tissue engineering applications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:Publisher
[do] DOI:10.1080/09205063.2018.1433420

  10 / 19351 MEDLINE  
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[PMID]: 29294376
[Au] Autor:Zhao C; Wang S; Wang G; Su M; Song L; Chen J; Fan S; Lin X
[Ad] Address:Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.
[Ti] Title:Preparation of decellularized biphasic hierarchical myotendinous junction extracellular matrix for muscle regeneration.
[So] Source:Acta Biomater;68:15-28, 2018 03 01.
[Is] ISSN:1878-7568
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Muscle injury and defect affect people's quality of life, and effective treatment is lacking. Herein, we generated a scaffold to obtain decellularized porcine Achilles tendon myotendinous junction (D-MTJ) extracellular matrix (ECM) with well-preserved native biphasic hierarchical structure, biological composition, and excellent mechanical properties for muscle regeneration. The combined use of potassium chloride, potassium iodide, Triton-X 100, and sodium-dodecyl sulfate (SDS) can completely remove the main immunogenicity, while maintaining the major biological components and microstructure. The specific biomechanics of D-MTJ is comparable to the native muscle-tendon physiological conditions. Additionally, the D-MTJ ECM scaffold induced minimal immunological reaction (histology analysis) through rat subcutaneous implantation. Moreover, in vitro, muscle satellite cells adhered, proliferated, and infiltrated into the D-MTJ scaffold, and myofiber-like cell differentiation was observed as shown by increased expression of myogenesis-related genes during culture. In vivo, newly formed myofibers were observed in a muscle defect model with D-MTJ orthotopic transplantation, while the control group presented mostly with fibrous tissue deposition. Additionally, the number of Myod and MyHC-positive cells in the ECM scaffold group was higher at day 30. We preliminary explored the mechanisms underlying D-MTJ-mediated muscle regeneration, which may be attributed to its specific biphasic hierarchical structure, bio-components, and attractiveness for myogenesis cells. In conclusion, our findings suggest the D-MTJ ECM scaffold prepared in this study is a promising choice for muscle regeneration. STATEMENT OF SIGNIFICANCE: This study is the first to use decellularization technology obtaining the specifically decellularized myotendinous junction (D-MTJ) with well-preserved biphasic hierarchical structure and constituents, excellent mechanical properties and good biocompatibility. The D-MTJ was further proved to be efficient for muscle regeneration in vitro and in vivo, and the underlying mechanisms may be attributed to its specifically structure and constituents, improved myogenesis and good preservation of repair-related factors. Our study may provide basis for the decellularization of other biphasic hierarchical tissues and a platform for further studies on muscle fiber and tendon integrations in vitro.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1801
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:In-Process


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