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Search on : splenic and infarction [Words]
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[PMID]: 29371436
[Au] Autor:Finn C; Hung P; Patel P; Gupta A; Kamel H
[Ad] Address:From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, New York, NY (C.F., P.H., H.K.); and Departments of Radiology (P.P., A.G.) and Neurology (A.G., H.K.), Weill Cornell Medical College, New York, NY.
[Ti] Title:Relationship Between Visceral Infarction and Ischemic Stroke Subtype.
[So] Source:Stroke;49(3):727-729, 2018 03.
[Is] ISSN:1524-4628
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND AND PURPOSE: Most cryptogenic strokes are thought to have an embolic source. We sought to determine whether cryptogenic strokes are associated with visceral infarcts, which are usually embolic. METHODS: Among patients prospectively enrolled in CAESAR (Cornell Acute Stroke Academic Registry), we selected those with a contrast-enhanced abdominal computed tomographic scan within 1 year of admission. Our exposure variable was adjudicated stroke subtype per the Trial of ORG 10172 in Acute Stroke Treatment classification. Our outcome was renal or splenic infarction as assessed by a single radiologist blinded to stroke subtype. We used Fisher exact test and multiple logistic regression to compare the prevalence of visceral infarcts among cardioembolic strokes, strokes of undetermined etiology, and noncardioembolic strokes (large- or small-vessel strokes). RESULTS: Among 227 patients with ischemic stroke and a contrast-enhanced abdominal computed tomographic scan, 59 had a visceral infarct (35 renal and 27 splenic). The prevalence of visceral infarction was significantly different among cardioembolic strokes (34.2%; 95% confidence interval [CI], 23.7%-44.6%), strokes of undetermined etiology (23.9%; 95% CI, 15.0%-32.8%), and strokes from large-artery atherosclerosis or small-vessel occlusion (12.5%; 95% CI, 1.8%-23.2%; =0.03). In multiple logistic regression models adjusted for demographics and vascular comorbidities, we found significant associations with visceral infarction for both cardioembolic stroke (odds ratio, 3.5; 95% CI, 1.2-9.9) and stroke of undetermined source (odds ratio, 3.3; 95% CI, 1.1-10.5) as compared with noncardioembolic stroke. CONCLUSIONS: The prevalence of visceral infarction differed significantly across ischemic stroke subtypes. Cardioembolic and cryptogenic strokes were associated with a higher prevalence of visceral infarcts than noncardioembolic strokes.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1161/STROKEAHA.117.020035

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[PMID]: 29511119
[Au] Autor:Halade GV; Norris PC; Kain V; Serhan CN; Ingle KA
[Ad] Address:Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ganeshhalade@uabmc.edu.
[Ti] Title:Splenic leukocytes define the resolution of inflammation in heart failure.
[So] Source:Sci Signal;11(520), 2018 Mar 06.
[Is] ISSN:1937-9145
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Inflammation promotes healing in myocardial infarction but, if unresolved, leads to heart failure. To define the inflammatory and resolving responses, we quantified leukocyte trafficking and specialized proresolving mediators (SPMs) in the infarcted left ventricle and spleen after myocardial infarction, with the goal of distinguishing inflammation from its resolution. Our data suggest that the spleen not only served as a leukocyte reservoir but also was the site where SPMs were actively generated after coronary ligation in mice. Before myocardial infarction, SPMs were more abundant in the spleen than in the left ventricle. At day 1 after coronary ligation, the spleen was depleted of leukocytes, a phenomenon that was associated with greater numbers of leukocytes in the infarcted left ventricle and increased generation of SPMs at the same site, particularly resolvins, maresin, lipoxins, and protectin. In addition, the infarcted left ventricle showed increased expression of genes encoding lipoxygenases and enhanced production of SPMs generated by these enzymes. We found that macrophages were necessary for SPM generation. The abundance of SPMs in the spleen before myocardial infarction and increased SPM concentrations in the infarcted left ventricle within 24 hours after myocardial infarction were temporally correlated with the resolution of inflammation. Thus, the acute inflammatory response coincided with the active resolving phase in post-myocardial infarction and suggests that further investigation into macrophage-derived SPMs in heart failure is warranted.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

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[PMID]: 29208262
[Au] Autor:Chou DW; Lin YW
[Ad] Address:Department of Critical Care Medicine, Tainan Municipal Hospital, Tainan, Taiwan. Electronic address: choudw@gmail.com.
[Ti] Title:Splenic Infarction and Rupture Due to Melioidosis.
[So] Source:Am J Med Sci;354(6):633-634, 2017 12.
[Is] ISSN:1538-2990
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Melioidosis/diagnostic imaging
Rupture, Spontaneous/diagnostic imaging
Splenic Infarction/diagnostic imaging
Splenic Rupture/diagnostic imaging
[Mh] MeSH terms secundary: Diabetes Complications/diagnostic imaging
Female
Humans
Melioidosis/complications
Middle Aged
Rupture, Spontaneous/etiology
Splenic Infarction/etiology
Splenic Rupture/etiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171207
[St] Status:MEDLINE

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[PMID]: 29489979
[Au] Autor:Resorlu M; Aylanc N; Karatag O; Toprak CA
[Ad] Address:Department of Radiology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
[Ti] Title:Gaucher's disease in a patient presenting with hip and abdominal pain.
[So] Source:Rev Assoc Med Bras (1992);63(12):1025-1027, 2017 Dec.
[Is] ISSN:1806-9282
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Gaucher's disease is characterized by glucocerebroside accumulation in the cells of the reticuloendothelial system. There are three subtypes. The most common is type 1, known as the non-neuropathic form. Pancytopenia, hepatosplenomegaly and bone lesions occur as a result of glucocerebroside accumulation in the liver, lung, spleen and bone marrow in these patients. Findings associated with liver, spleen or bone involvement may be seen at radiological analysis. Improvement in extraskeletal system findings is seen with enzyme replacement therapy. Support therapy is added in patients developing infection, anemia or pain. We describe a case of hepatosplenomegaly, splenic infarction, splenic nodules and femur fracture determined at radiological imaging in a patient under monitoring due to Gaucher's disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Process

  5 / 1683 MEDLINE  
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[PMID]: 29433117
[Au] Autor:Goto H; Tanaka T; Suetsugi N; Kubotsu Y; Momozaki N; Mizuta T
[Ad] Address:Department of Neurology, Imari Arita Kyoritsu Hospital.
[Ti] Title:[Non-cirrhotic Portal-systemic Encephalopathy with Total Aphasia and Right Hemiplegia Following Transient Right Hemiparesis: A Case Report].
[So] Source:Brain Nerve;70(2):155-159, 2018 Feb.
[Is] ISSN:1881-6096
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:A 77-year-old right-handed woman without any liver diseases was admitted to our hospital because of transient right hemiparesis. She developed total aphasia with right hemiplegia on the third hospital day. We suspected that she had a cerebral infarction following a transient ischemic attack. However, brain diffusion-weighted images revealed no abnormal-intensity lesions, and cerebral angiography showed patent arteries. Additionally, her serum ammonia level was elevated. Theta waves without triphasic waves were detected by electroencephalogram. T1-weighted magnetic resonance brain images revealed high-intensity signals in the bilateral globus pallidus. Enhanced abdominal computed tomography showed a portal-systemic shunt from the splenic and inferior mesenteric veins into the left renal vein via the left ovarian vein. The administration of branched-chain amino acids and lactulose improved her clinical symptoms. We confirmed the diagnosis of non-cirrhotic portal-systemic encephalopathy (NCPSE), therefore balloon-occluded retrograde transvenous obliteration of the shunt vessel was performed. The recognition of NCPSE on the examination of a suspected stroke patient is important, as patients with NCPSE can present as stroke mimics. (Received June 26, 2017; Accepted August 22, 2017; Published February 1, 2018).
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180212
[Lr] Last revision date:180212
[St] Status:In-Data-Review
[do] DOI:10.11477/mf.1416200968

  6 / 1683 MEDLINE  
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SciELO Brazil full text

[PMID]: 29340557
[Au] Autor:Ghersin I; Leiba A
[Ad] Address:Medical Corps, Israeli Defense Force, Tel-Hashomer, Ramat-Gan, Israel.
[Ti] Title:AN UNUSUAL CAUSE OF ACUTE ABDOMEN: SPLENIC INFARCTION.
[So] Source:Arq Bras Cir Dig;30(4):289-290, 2017 Oct-Dec.
[Is] ISSN:2317-6326
[Cp] Country of publication:Brazil
[La] Language:eng; por
[Pt] Publication type:LETTER
[Em] Entry month:1801
[Cu] Class update date: 180206
[Lr] Last revision date:180206
[St] Status:In-Data-Review

  7 / 1683 MEDLINE  
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[PMID]: 29351102
[Au] Autor:Febres-Aldana CA; Hernandez Howard L
[Ad] Address:From the Arkadi M. Rywlin, MD, Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL.
[Ti] Title:Fatal Sickling Triggered by Massive Foreign Particle Embolism: A Case Report of Unrecognized Indwelling Venous Catheter Drug Abuse in Sickle Cell Disease.
[So] Source:Am J Forensic Med Pathol;, 2018 Jan 18.
[Is] ISSN:1533-404X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Sickle cell disease (SCD) manifests itself with vaso-occlusive episodes leading to infarction. Placement of intravascular catheters provides a useful route for management of pain crises as well as other complications. However, catheter misuse is a commonly unrecognized problem, which can have lethal consequences. We present a case of fatal splenic sequestration/hyperhemolysis secondary to foreign body pulmonary and systemic embolization due to intravenous administration of hydromorphone pills in a young woman with SCD. Morphological identification of the embolized particles (crospovidone, microcrystalline cellulose, and hydrophilic polymer) was key in understanding the mechanism of death. Foreign particle deposition induced a granulomatous inflammatory response that resulted in obliteration and distortion of the microvasculature, thus triggering sickling with subsequent organ damage. Despite clinical evidence of asplenia and microscopic white pulp fibrosis with Gamna-Gandy body formation, unexpectedly for the patient's age, the spleen was enlarged by entrapped sickle cells. The findings support the possibility that loss of function can coexist with increased splenic activity under certain circumstances, an overlooked clinical phenotype of SCD. This case illustrates the teaching value of classic autopsy in addition to its crucial role in understanding the natural history of complex heterogeneous diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180119
[Lr] Last revision date:180119
[St] Status:Publisher
[do] DOI:10.1097/PAF.0000000000000378

  8 / 1683 MEDLINE  
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[PMID]: 29310334
[Au] Autor:Sun N; Lu G; Zhang L; Wang X; Gao C; Bi J; Wang X
[Ti] Title:Clinical efficacy of spleen-preserving distal pancreatectomy with or without splenic vessel preservation: A Meta-analysis.
[So] Source:Medicine (Baltimore);96(48):e8600, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The meta-analysis was performed to investigate the clinical efficacy of spleen-preserving distal pancreatectomy with splenic vessel preservation (SPDP-SVP) and spleen-preserving distal pancreatectomy with splenic vessel resection (SPDP-SVR). METHODS: Potential articles were searched on the databases of Pubmed, Embase, and Chinese National Knowledge Infrastructure (CNKI) from January 1988 until March 2017. Weight mean difference (WMD) with 95% confidence interval (CI) was applied to compare the efficacy of SPDP-SVP and SPDP-SVR. Odds ratio (OR) with 95% CI was calculated to figure out the risks for complications. P< .05 or I>50% indicated significant heterogeneity. The random-effects model is used to pool data if significant heterogeneity exists; otherwise, the fixed-effects model is used. Publication bias was evaluated by Begg's funnel plot. RESULTS: Thirteen eligible articles were obtained in the meta-analysis. SPDP-SVP seemed to relate with reduced operative time and blood loss, prolonged hospital stay, and less complications; however, the effects were not statistically significant. Meanwhile, we found that SPDP-SVP was closely related with the reduced rate of splenic infarction and gastric varices (OR = 0.16, 95% CI = 0.09-0.29; OR = 0.08, 95% CI = 0.02-0.35). No publication bias was observed in the analysis (P = .636). CONCLUSIONS: SPDP-SVP seems to show superiority than SPDP-SVR in reducing the rate of splenic infarction and gastric varices.
[Mh] MeSH terms primary: Pancreatectomy/methods
Spleen/blood supply
Spleen/surgery
[Mh] MeSH terms secundary: Blood Loss, Surgical/statistics & numerical data
Humans
Infarction/epidemiology
Length of Stay/statistics & numerical data
Operative Time
Postoperative Complications/epidemiology
Varicose Veins/epidemiology
[Pt] Publication type:JOURNAL ARTICLE; META-ANALYSIS
[Em] Entry month:1801
[Cu] Class update date: 180115
[Lr] Last revision date:180115
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008600

  9 / 1683 MEDLINE  
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[PMID]: 29284415
[Au] Autor:Achilli P; Guttadauro A; Bonfanti P; Terragni S; Fumagalli L; Cioffi U; Gabrielli F; De Simone M; Chiarelli M
[Ad] Address:University of Milan - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Sforza 35, 20122, Milan, Italy.
[Ti] Title:Streptococcus agalactiae infective endocarditis complicated by multiple mycotic hepatic aneurysms and massive splenic infarction: a case report.
[So] Source:BMC Gastroenterol;17(1):170, 2017 Dec 29.
[Is] ISSN:1471-230X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The burden of disease caused by Streptococcus agalactiae has increased significantly among older adults in the last decades. Group B streptococcus infection can be associated with invasive disease and severe clinical syndromes, such as meningitis and endocarditis. CASE PRESENTATION: We present the case of a 56-year-old man who developed multiple mycotic aneurysms of the right hepatic artery and massive splenic infarction as rare complications of Streptococcus agalactiae infective endocarditis. The patient underwent urgent right hepatic artery ligation and splenectomy. The postoperative course was complicated by an episode of hemobilia due to the rupture of a partially thrombosed mycotic aneurysm into the biliary tree. Thus, selective radiological embolization of the left hepatic artery branches was necessary. CONCLUSION: To our knowledge, this is the first case reported of infected aneurysms of visceral arteries caused by Group B streptococcus infection. Clinical and laboratory findings were non-specific, while imaging features with computed tomography scan and angiography were highly suggestive. In our case, early recognition, culture-specific intravenous antibiotics and urgent surgical treatment combined with interventional radiology played a decisive role in the final result.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180104
[Lr] Last revision date:180104
[St] Status:In-Process
[do] DOI:10.1186/s12876-017-0728-0

  10 / 1683 MEDLINE  
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[PMID]: 29263115
[Au] Autor:Jenke A; Schur R; Rger C; Karadeniz Z; Grger M; Holzhauser L; Savvatis K; Poller W; Schultheiss HP; Landmesser U; Skurk C
[Ad] Address:Department of Cardiology, Charit University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany.
[Ti] Title:Adiponectin attenuates profibrotic extracellular matrix remodeling following cardiac injury by up-regulating matrix metalloproteinase 9 expression in mice.
[So] Source:Physiol Rep;5(24), 2017 Dec.
[Is] ISSN:2051-817X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Adiponectin (APN) is a multifunctional adipocytokine that inhibits myocardial fibrosis, dilatation, and left ventricular (LV) dysfunction after myocardial infarction (MI). Coxsackievirus B3 (CVB3) myocarditis is associated with intense extracellular matrix (ECM) remodeling which might progress to dilated cardiomyopathy. Here, we investigated in experimental CVB3 myocarditis whether APN inhibits adverse ECM remodeling following cardiac injury by affecting matrix metalloproteinase (MMP) expression. Cardiac injury was induced by CVB3 infection in APN knockout (APN-KO) and wild-type (WT) mice. Expression and activity of MMPs was quantified by qRT-PCR and zymography, respectively. Activation of protein kinases was assessed by immunoblot. In cardiac myocytes and fibroblasts APN up-regulates MMP-9 expression via activation of 5' adenosine monophosphate-activated protein kinase (AMPK) and extracellular signal-regulated kinase (ERK)1/2 which function as master regulators of inflammation-induced MMP-9 expression. Correspondingly, APN further increased up-regulation of MMP-9 expression triggered by tumor necrosis factor (TNF)α, lipopolysaccharide (LPS) and R-848 in cardiac fibroblasts. In vivo, compared to WT mice cardiac MMP-9 activity and serum levels of carboxy-terminal telopeptide of type I collagen (ICTP) were attenuated in APN-KO mice in subacute (day 7 p.i.) CVB3 myocarditis. Moreover, on day 3 and day 7 post CVB3 infection splenic MMP-9 expression was diminished in APN-KO mice correlating with attenuated myocardial immune cell infiltration in subacute CVB3 myocarditis. These results indicate that APN attenuates adverse cardiac remodeling following cardiac injury by up-regulating MMP-9 expression in cardiac and immune cells. Thus, APN mediates intensified collagen cleavage that might explain inhibition of LV fibrosis and dysfunction.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180104
[Lr] Last revision date:180104
[St] Status:In-Process


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