Database : MEDLINE
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[PMID]: 29515750
[Au] Autor:Aradoini N; Talbi S; Azzouzi H; Abourazzak FZ; Khibri H; Berrady R; Bono W; Harzy T
[Ad] Address:Faculté de Médecine, Université Sidi Mohamed Ben Abdallah, Service de Rhumatologie, Centre Hospitalier Universitaire Hassan II, Fès, Maroc.
[Ti] Title:Spondylarthrite ankylosante et maladie de Still: un lien physiopathologique ou une simple association? [Ankylosing spondylitis associated with Still's disease: should it be considered a pathophysiologic link or a simple association?]
[So] Source:Pan Afr Med J;28:132, 2017.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:fre
[Ab] Abstract:Ankylosing spondylitis is a chronic inflammatory rheumatism; it is part of the group of spondyloarthrites. General signs such as fever and weight loss are of little importance. Adult Still's disease is a rare systemic condition, a diagnosis of exclusion commonly characterized by high hectic fever, rash, arthritis and various systemic manifestations. Few cases of ankylosing spondylitis associated with adult Still's disease have been described in the literature. We here report the case of a 31-year old patient followed up for ankylosing spondylitis presenting with fever which had lasted for a long time and clinico-biological signs compatible with adult Still's disease. A possible pathophysiologic link between the two diseases may be suggested, even if their simultaneous occurrence has been rarely reported in the literature.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.11604/pamj.2017.28.132.5607

  2 / 20081 MEDLINE  
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[PMID]: 29438717
[Au] Autor:Zhang L; Zhang YJ; Chen J; Huang XL; Fang GS; Yang LJ; Duan Y; Wang J
[Ad] Address:Medical Genetics Center, Anhui Medical College, Hefei, China.
[Ti] Title:The association of HLA-B27 and Klebsiella pneumoniae in ankylosing spondylitis: A systematic review.
[So] Source:Microb Pathog;117:49-54, 2018 Feb 10.
[Is] ISSN:1096-1208
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Ankylosing spondylitis (AS) is a chronic inflammatory arthritis of unknown origin. Its autoimmune origin has been suggested but never proven. Several reports have implicated K. pneumoniae as a triggering or perpetuating factor in AS; and the HLA-B27 antigen has also been found in association with AS. But there is no satisfactory explanation of why the presence of HLA-B27 predisposes to AS and the precise role played by K. pneumoniae in the disease has not yet been clarified. However, various studies have shown that the results of molecular, immunological, and microbiological studies could establish the link between K. pneumoniae infections and HLA-B27 in the aetiopathogenesis of AS. In this review, we have examined the evidence linking the interaction between K. pneumoniae infections and HLA-B27 in AS, and tried to exploit the possible mechanisms by which K. pneumoniae infections might induce pathologic processes to develop novel diagnostic criteria. Finally, we have also summarized some dietary regimens that could be helpful in the therapeutic management of AS patients.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 20081 MEDLINE  
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[PMID]: 29524036
[Au] Autor:Akhtari M; Zargar SJ; Mahmoudi M; Vojdanian M; Rezaeimanesh A; Jamshidi A
[Ad] Address:Department of Cell & Molecular Biology, School of Biology, College of Science, University of Tehran, P.O. Box: 141556455, Tehran, Iran.
[Ti] Title:Ankylosing spondylitis monocyte-derived macrophages express increased level of A adenosine receptor and decreased level of ectonucleoside triphosphate diphosphohydrolase-1 (CD39), A and A adenosine receptors.
[So] Source:Clin Rheumatol;, 2018 Mar 09.
[Is] ISSN:1434-9949
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Macrophages play an important role in the ankylosing spondylitis (AS) auto-inflammatory responses and fibrocartilage destruction. Adenosine is a key modulator of inflammatory conditions. The various effects of adenosine are mediated by its interaction with adenosine receptors (AR). In this study, we investigated the mRNA expression of A , A , A , and A adenosine receptors, ectonucleoside triphosphate diphosphohydrolase-1 (CD39), and ecto-5'-nucleotidase (CD73) in the monocyte-derived macrophages from AS patients in comparison to healthy controls. We also explored the correlation between analyzed gene expression and patients' clinical manifestations. Whole blood-separated monocytes from 23 healthy controls and 23 active AS patients were stimulated by macrophage colony-stimulating factor (M-CSF) for 7 days and differentiated to macrophages. Monocyte and macrophage markers were analyzed by flow cytometry. Analysis of adenosine receptors (ADORA1، ADORA2A، ADORA2B، ADORA3), CD39 and CD73 gene expression was performed by SYBR green real-time PCR. Our results demonstrated monocyte-derived macrophages from AS patients expressed increased level of A AR and reduced level of A , A AR, and CD39 mRNA compared to healthy controls. We found an inverse correlation between A AR mRNA expression and Bath Ankylosing Spondylitis Functional Index (BASFI) score in AS patients. According to our results, altered expression level of adenosine-relying system would be involved in AS macrophage dysfunction and inflammation and correlated with functional status in AS patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1007/s10067-018-4055-9

  4 / 20081 MEDLINE  
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[PMID]: 29523520
[Au] Autor:Mathieu S; Soubrier M
[Ad] Address:Rheumatology Department, Clermont University, Gabriel Montpied Teaching Hospital, Clermont-Ferrand, France.
[Ti] Title:Cardiovascular events in ankylosing spondylitis: a 2018 meta-analysis.
[So] Source:Ann Rheum Dis;, 2018 Mar 09.
[Is] ISSN:1468-2060
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  5 / 20081 MEDLINE  
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[PMID]: 29518861
[Au] Autor:Ji XJ; Sun K; Hu ZY; Zhang Y; Ma YP; Sun Z; Li KP; Zhu J; Zhang JL; Huang F
[Ti] Title:[Comparison of clinical manifestations according to HLA-B(27) genotype in ankylosing spondylitis patients: real-world evidence from smart management system for spondyloarthritis].
[So] Source:Zhonghua Nei Ke Za Zhi;57(3):179-184, 2018 Mar 01.
[Is] ISSN:0578-1426
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:The aim of this study was to set up a large, longitudinal and prospective database to compare the clinical manifestations in human leucocyte antigen (HLA)-B(27) positive and negative patients with ankylosing spondylitis(AS) based on real-world evidence in Chinese population. A total of 897 outpatients with confirmed AS were recruited consecutively by smart management system for spondyloarthritis (SMSP) from April 13, 2016 to June 6, 2017 in Chinese PLA General Hospital from 30 provinces and autonomous regions. 801 patients with HLA-B(27) data were included in the analysis. Demographic and clinical parameters including Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI), ankylosing spondylitis disease activity score (ASDAS), arthritis, enthesitis, Bath ankylosing spondylitis metrology index (BASMI), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were compared between HLA-B(27) positive and negative groups. A total of 801 patients were included in the analysis with an average age of (30.7±8.8) years. There were 659 males and 142 females and HLA-B(27) was present in 88.0%(705/801). Males were significantly more in HLA-B(27) positive patients [83.3%(587/705) vs. 75.0%(72/96); 0.047].The average age at disease onset was (22.3±7.6)years in HLA-B(27) positive patients and (24.4±8.7) years in HLA-B(2)7 negative ones ( 0.028).There was significant difference in diagnose delay between two groups [14.3(2.5,43.6)months in HLA-B(27) positive patients vs. 20.3(5.0,67.4) months in HLA-B(27) negative ones, 0.041]. Anterior uveitis was found to be significantly more common in HLA-B(27) positive patients [18.9% (133/705)vs.7.3%(7/96), 0.005], and knee involvement less common in HLA-B(27) positive patients [4.0%(27/682) vs.10.0%(9/90), 0.010], conversely. CRP[6.5(3.0, 16.4)mg/L vs. 3.5(1.6, 12.3)mg/L] and ESR[11.0(4.0, 24.0)mm/1h vs. 7.0(3.0, 16.0)mm/1h] were significantly higher in HLA-B(27) positive patients( 0.005,0.013, respectively).But no differences in BASDAI,ASDAS,BASFI and BASMI were obtained between two groups. HLA-B(27) positive patients had a higher proportion of males, a younger age of onset and a greater risk for occurrence of anterior uveitis, suggesting a poorer prognosis.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.3760/cma.j.issn.0578-1426.2018.03.006

  6 / 20081 MEDLINE  
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[PMID]: 29518859
[Au] Autor:Xu SQ; Huang F
[Ti] Title:[Management of extra-articular manifestations in ankylosing spondylitis].
[So] Source:Zhonghua Nei Ke Za Zhi;57(3):171-174, 2018 Mar 01.
[Is] ISSN:0578-1426
[Cp] Country of publication:China
[La] Language:chi
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.3760/cma.j.issn.0578-1426.2018.03.004

  7 / 20081 MEDLINE  
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[PMID]: 29517554
[Au] Autor:Chiowchanwisawakit P; Katchamart W; Osiri M; Narongroeknawin P; Chevaisrakul P; Kitumnuaypong T; Siripaitoon B; Louthrenoo W
[Ti] Title:Effectiveness and Drug Survival of Anti-Tumor Necrosis Factor α Therapies in Patients With Spondyloarthritis: Analysis From the Thai Rheumatic Disease Prior Authorization Registry.
[So] Source:J Clin Rheumatol;, 2018 Mar 07.
[Is] ISSN:1536-7355
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: This study aimed to evaluate the long-term effectiveness and safety of the first anti-tumor necrosis factor α therapy (TNFi) and to identify the associated factors of drug discontinuation in patients with spondyloarthritis. METHODS: This was a retrospective cohort study. Patients with spondyloarthritis who were prescribed the first TNFi between December 2009 and October 2014 in the Rheumatic Disease Prior Authorization registry were enrolled. Baseline clinical data were retrieved. The Cox proportional hazards model was used to identify factors associated with discontinuation of drugs. RESULTS: Among 138 patients, 97 had ankylosing spondylitis (AS), and 41 had psoriatic arthritis (PsA). The effectiveness of TNFi in AS and PsA was 55% to 59% at 4 months and 75% to 96% at 3 years, as measured by a 50% decrease in the Bath Ankylosing Spondylitis Disease Activity Index from baseline. For PsA with peripheral arthritis, improvement of the joint count by 50% was observed in 61.8% of patients at 4 months and 100% at 3 years. Survival from TNFi was 63% for AS and 56% for PsA at 3 years. For AS, the factors associated with good response leading to discontinuation of TNFi were baseline patient global assessment 3 to 6/10 (hazard ratio [HR], 6.3) and the use of leflunomide (HR, 6.0) and infliximab (HR, 4.8). A good response (38.5%) was the most common cause of discontinuation of the first TNFi, followed by toxicity (28.2%), nonadherence (20.5%), and lack of effectiveness (12.8%). CONCLUSIONS: Ankylosing spondylitis and PsA responded well to TNFi during the 3-year follow-up. The retention rate was approximately 60% for AS and PsA. A good response to the first TNFi was the most common reason for discontinuation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1097/RHU.0000000000000741

  8 / 20081 MEDLINE  
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[PMID]: 29196944
[Au] Autor:Konur O
[Ad] Address:Ankara Yildirim Beyazit University, Dumlupinar Mahallesi, Cubuk, 96760, Ankara, Turkey. okonur@hotmail.com.
[Ti] Title:Scientometric evaluation of the global research in spine: an update on the pioneering study by Wei et al.
[So] Source:Eur Spine J;27(3):524-529, 2018 Mar.
[Is] ISSN:1432-0932
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: Wei et al. evaluated the global research in spine using scientometric methods based on a sample of 13,115 papers published in 5 spine journals from 2004 to 2013. This study builds on this pioneering study and provides up-to-date and thorough information on spine based on a sample of 166,962 papers for the stakeholders. METHOD: 'Articles' and 'reviews' published in 'English' in the journals indexed by the 'Web of Science' primary databases between 1980 and 2017 were retrieved through the use of an optimal keyword set for titles of both papers and ten spine journals. The information on document types and number of papers, authors, countries, funding bodies, institutions, publication years, journals, 'Web of Science' subject categories, and ten top citation classics were analyzed. RESULTS: A large sample of 166,962 papers were retrieved. The 'reviews' and 'proceedings papers' formed 5.8 and 2.8% of the sample, respectively. 'Fehlings', 'Vaccaro', 'Takahashi', 'Lenke', and 'Gokaslan' were the most-prolific authors. Nearly 0.7% of the papers had group authors besides single authors. The US was the most prolific country publishing 37.3% of the sample whilst Europe contributed to more than 39.8% of the sample. Only, 26.6% of the papers disclosed research funding. Among 40,897 institutions, 'Harvard University' was the most-prolific institution whilst the US institutions dominated the top-institution list. The research output steadily rose from 1375 papers in 1980 to 9357 papers in 2016 whilst 69.2% of the papers were published after 2000. Ten spine journals published only 23.4% of the sample. 'Clinical Neurology', 'Orthopedics', 'Neurosciences', and 'Surgery' was the most prolific subject categories. The top citation classic was a paper by van der Linden et al. on ankylosing spondylitis. CONCLUSIONS: The optimal design of research sample made it possible to obtain nearly 13 times the size of the sample in Wei et al. as a true representation of the research in spine through the use of an optimal keyword set for the titles of both papers and 10 spine journals. However, despite the inefficient design of the incentive structures for the relevant stakeholders, the research in spine had expanded 6.8 times since 1980.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1007/s00586-017-5411-1

  9 / 20081 MEDLINE  
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[PMID]: 28453761
[Au] Autor:Karreman MC; Luime JJ; Hazes JMW; Weel AEAM
[Ad] Address:Erasmus University Medical Center, Wytemaweg 80, Rotterdam, The Netherlands.
[Ti] Title:The Prevalence and Incidence of Axial and Peripheral Spondyloarthritis in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
[So] Source:J Crohns Colitis;11(5):631-642, 2017 May 01.
[Is] ISSN:1876-4479
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Background and Aims: Inflammatory bowel disease [IBD] is a chronic disease which affects up to 0.5% of the population. Various extraintestinal manifestations occur, among which are rheumatic manifestations, grouped together under the name spondyloarthritis. The objective of this systematic review and meta-analysis was to give a systematic overview of the prevalence and incidence of spondyloarthritis in patients with inflammatory bowel disease. Methods: We systematically searched Embase, Pubmed, OvidSP, Scopus, and Web-of-Science databases from inception to August 2016. All articles that addressed the prevalence or incidence of the different features of spondyloarthritis in adult inflammatory bowel disease patients were included. Methodological quality was assessed using a modified quality assessment tool developed for prevalence studies. Results: A total of 71 studies were included, reporting on the prevalence of sacroiliitis, ankylosing spondylitis, arthritis, enthesitis, and dactylitis. Pooled prevalences were calculated for sacroiliitis (10%; 95% confidence interval [CI] 8-12%), ankylosing spondylitis [3%; 95% CI 2-4%], and arthritis [13%; 95% CI 12-15%]. Geographical area, setting and use of different criteria contribute to the large heterogeneity. Few estimates were available for enthesitis [prevalence range from 1% to 54%] and dactylitis [prevalence range from 0% to 6%]. Only three incidence studies were identified, which report cumulative incidences from 5 to 30 years. Conclusions: Spondyloarthritis occurs in up to 13% of patients with IBD. Ankylosing spondylitis is the least common [3%] followed by sacroiliitis [10%] and peripheral arthritis [13%].
[Mh] MeSH terms primary: Inflammatory Bowel Diseases/complications
Spondylarthritis/complications
[Mh] MeSH terms secundary: Arthritis/complications
Arthritis/epidemiology
Humans
Incidence
Prevalence
Sacroiliitis/complications
Sacroiliitis/epidemiology
Spondylarthritis/epidemiology
Spondylitis, Ankylosing/complications
Spondylitis, Ankylosing/epidemiology
[Pt] Publication type:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:170429
[St] Status:MEDLINE
[do] DOI:10.1093/ecco-jcc/jjw199

  10 / 20081 MEDLINE  
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[PMID]: 29390089
[Au] Autor:Hammer NM; Midtgaard J; Hetland ML; Krogh NS; Esbensen BA
[Ad] Address:The DANBIO Registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.
[Ti] Title:Physical activity behaviour in men with inflammatory joint disease: a cross-sectional register-based study.
[So] Source:Rheumatology (Oxford);, 2018 Jan 29.
[Is] ISSN:1462-0332
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Objectives: Physical activity is recommended as an essential part of the non-pharmacological management of inflammatory joint disease, but previous research in this area has predominantly included women. The aim of this study was to examine physical activity behaviour in men with inflammatory joint disease. Methods: The study was conducted as a cross-sectional register-based study. Data on physical activity behaviour in men with RA, PsA and AS were matched with sociodemographic and clinical variables extracted from the DANBIO registry. Logistic regression analyses using multiple imputations were performed to investigate demographic and clinical variables associated with regular engagement in physical activity (moderate-vigorous ⩾2 h/week). Descriptive statistics were applied to explore motivation, barriers and preferences for physical activity. Results: A total of 325 men were included of whom 129 (40%) engaged in regular physical activity. In univariate analyses, higher age, visual analogue scale (VAS) for pain, VAS fatigue, VAS patient's global, CRP level, disease activity, functional disability and current smoking were negatively associated with regular engagement in physical activity. In the final multivariable regression model only a high VAS fatigue score (⩾61 mm) (OR = 0.228; CI: 0.119, 0.436) remained significantly independently associated with regular physical activity. Conclusion: A majority of men with inflammatory joint disease do not meet the recommendations of regular physical activity. Both sociodemographic and clinical parameters were associated with engagement in physical activity, and fatigue especially seems to play a pivotal role in explaining suboptimal physical activity behaviour in this patient group.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1093/rheumatology/kex498


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