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[PMID]: 29166774
[Au] Autor:Zhou X; Huang S; Wang P; Luo Q; Huang X; Xu Q; Qin J; Liang C; Chen X
[Ad] Address:a College of Pharmacy , Guilin Medical University , Guilin , P. R. China.
[Ti] Title:A syringic acid derivative and two iridoid glycosides from the roots of Stachys geobombycis and their antioxidant properties.
[So] Source:Nat Prod Res;:1-6, 2017 Nov 22.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A new derivative of syringic acid, stageobester A (1) and two iridoid glycosides which including a new one, stageoboside A (2), were isolated from the roots of Stachys geobombycis. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all the isolates were tested for their antioxidant capacity. Compounds 1 and 2 showed moderate antioxidant activities against DPPH radical, with IC values of 113.33 ± 1.53 and 40.33 ± 2.08 mg/L, respectively.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171123
[Lr] Last revision date:171123
[St] Status:Publisher
[do] DOI:10.1080/14786419.2017.1405413

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[PMID]: 28830833
[Au] Autor:Graham KK; Brown S; Clarke S; Röse USR; Starks PT
[Ad] Address:Department of Biology, Tufts University, Medford, MA 02155, USA. Electronic address: kelsey.katherine.graham@gmail.com.
[Ti] Title:The European wool-carder bee (Anthidium manicatum) eavesdrops on plant volatile organic compounds (VOCs) during trichome collection.
[So] Source:Behav Processes;144:5-12, 2017 Nov.
[Is] ISSN:1872-8308
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The plant-pollinator relationship is generally considered mutualistic. This relationship is less clear, however, when pollinators also cause tissue damage. Some Megachilidae bees collect plant material for nests from the plants they pollinate. In this study, we examined the relationship between Anthidium manicatum, the European wool-carder bee, and the source of its preferred nesting material - Stachys byzantina, lamb's ear. Female A. manicatum use their mandibles to trim trichomes from plants for nesting material (a behaviour dubbed "carding"). Using volatile organic compound (VOC) headspace analysis and behavioural observations, we explored (a) how carding effects S. byzantina and (b) how A. manicatum may choose specific S. byzantina plants. We found that removal of trichomes leads to a dissimilar VOC bouquet compared to intact leaves, with a significant increase in VOC detection following damage. A. manicatum also visit S. byzantina plants with trichomes removed at a greater frequency compared to plants with trichomes intact. Our data suggest that A. manicatum eavesdrop on VOCs produced by damaged plants, leading to more carding damage for individual plants due to increased detectability by A. manicatum. Accordingly, visitation by A. manicatum to S. byzantina may incur both a benefit (pollination) and cost (tissue damage) to the plant.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171013
[Lr] Last revision date:171013
[St] Status:In-Process

  3 / 172 MEDLINE  
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[PMID]: 28317417
[Au] Autor:Panahi Kokhdan E; Ahmadi K; Sadeghi H; Sadeghi H; Dadgary F; Danaei N; Aghamaali MR
[Ad] Address:a Department of Biology, Faculty of Science , Guilan University , Rasht , Iran.
[Ti] Title:Hepatoprotective effect of Stachys pilifera ethanol extract in carbon tetrachloride-induce hepatotoxicity in rats.
[So] Source:Pharm Biol;55(1):1389-1393, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: Stachys pilifera Benth (Lamiaceae) has long been used to treat infectious diseases, respiratory and rheumatoid disorders in Iranian folk medicine. Antitumor and antioxidant activity of the plant have been reported. OBJECTIVE: The study was designed to assess the hepatoprotective activity of ethanol extract of Stachys pilifera in carbon tetrachloride (CCl )-induced hepatotoxicity in rats. MATERIALS AND METHODS: The rats were randomly divided into six equal groups (n = 7). Group I was treated with normal saline; Group II received CCl (1 mL/kg. i.p., twice a week) for 60 consecutive days; Groups III, IV and V were given CCl plus Stachys pilifera (100, 200 and 400 mg/kg/d,p.o.); Group VI received the extract (400 mg/kg/d, p.o.). Histopathological analysis and measurement of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), malondialdehyde (MDA), total protein (TP) and albumin (ALB) were performed. RESULTS: CCl caused a significant increase in the serum levels of AST, ALT, ALP and MDA as well as decreased ALB, and TP serum levels (p < 0.001). The extract (200 and 400 mg/kg/d) significantly normalized the CCl -elevated levels of ALT, AST, ALP and MDA (p < 0.001). The extract (200 and 400 mg/kg/d) also increased the serum levels of TP compared to CCl group (p< 0.01). The extract (200 and 400 mg/kg/d) also decreased the histological injuries (inflammation and fatty degeneration) by CCl . DISCUSSION: The results revealed that the Stachys pilifera extract could provide considerable protection against CCl hepatotoxicity in rats that may be related to its antioxidant properties.
[Mh] MeSH terms primary: Antioxidants/pharmacology
Carbon Tetrachloride
Chemical and Drug Induced Liver Injury/prevention & control
Ethanol/chemistry
Liver/drug effects
Plant Extracts/pharmacology
Solvents/chemistry
Stachys/chemistry
[Mh] MeSH terms secundary: Alanine Transaminase/blood
Alkaline Phosphatase/blood
Animals
Antioxidants/isolation & purification
Aspartate Aminotransferases/blood
Biomarkers/blood
Chemical and Drug Induced Liver Injury/blood
Chemical and Drug Induced Liver Injury/etiology
Chemical and Drug Induced Liver Injury/pathology
Cytoprotection
Disease Models, Animal
Lipid Peroxidation/drug effects
Liver/metabolism
Liver/pathology
Male
Malondialdehyde/blood
Phytotherapy
Plant Extracts/isolation & purification
Plant Leaves/chemistry
Plants, Medicinal
Rats, Wistar
Serum Albumin/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antioxidants); 0 (Biomarkers); 0 (Plant Extracts); 0 (Serum Albumin); 0 (Solvents); 3K9958V90M (Ethanol); 4Y8F71G49Q (Malondialdehyde); CL2T97X0V0 (Carbon Tetrachloride); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Entry month:1706
[Cu] Class update date: 170605
[Lr] Last revision date:170605
[Js] Journal subset:IM
[Da] Date of entry for processing:170321
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1302484

  4 / 172 MEDLINE  
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[PMID]: 28158941
[Au] Autor:Lang R; Lang T; Bader M; Beusch A; Schlagbauer V; Hofmann T
[Ad] Address:Chair for Food Chemistry and Molecular Sensory Science, Technische Universität München , Lise-Meitner-Straße 34, D-85354 Freising, Germany.
[Ti] Title:High-Throughput Quantitation of Proline Betaine in Foods and Suitability as a Valid Biomarker for Citrus Consumption.
[So] Source:J Agric Food Chem;65(8):1613-1619, 2017 Mar 01.
[Is] ISSN:1520-5118
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Proline betaine has been proposed as a candidate dietary biomarker for citrus intake. To validate its suitability as a dietary biomarker and to gain insight into the range of this per-methylated amino acid in foods and beverages, a quick and accurate stable isotope dilution assay was developed for quantitative high-throughput HILIC-MS/MS screening of proline betaine in foods and urine after solvent-mediated matrix precipitation. Quantitative analysis of a variety of foods confirmed substantial amounts of proline betaine in citrus juices (140-1100 mg/L) and revealed high abundance in tubers of the vegetable Stachys affinis, also known as Chinese artichocke (∼700 mg/kg). Seafood including clams, shrimp, and lobster contained limited amounts (1-95 mg/kg), whereas only traces were detected in fish, cuttlefish, fresh meat, dairy products, fresh vegetable (<3 mg/kg), coffee, tea, beer, and wine (<7 mg/L). The human excretion profiles of proline betaine in urine were comparable when common portions of orange juice or fried Stachys tubers were consumed. Neither mussels nor beer provided enough proline betaine to detect significant differences between morning urine samples collected before and after consumption. As Stachys is a rather rare vegetable and not part of peoples' daily diet, the data reported here will help to monitor the subject's compliance in future nutritional human studies on citrus products or the exclusion of citrus products in the wash-out phase of an intervention study. Moreover, proline betaine measurement can contribute to the establishment of a toolbox of valid dietary biomarkers reflecting wider aspects of diet to assess metabolic profiles as measures of dietary exposure and indicators of dietary patterns, dietary changes, or effectiveness of dietary interventions.
[Mh] MeSH terms primary: Betaine/urine
Beverages/analysis
Citrus/metabolism
Fruit/metabolism
Proline/urine
[Mh] MeSH terms secundary: Adult
Betaine/metabolism
Biomarkers/metabolism
Biomarkers/urine
Female
High-Throughput Screening Assays
Humans
Male
Proline/metabolism
Tandem Mass Spectrometry
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers); 3SCV180C9W (Betaine); 9DLQ4CIU6V (Proline)
[Em] Entry month:1705
[Cu] Class update date: 170530
[Lr] Last revision date:170530
[Js] Journal subset:IM
[Da] Date of entry for processing:170205
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b05824

  5 / 172 MEDLINE  
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[PMID]: 27979230
[Au] Autor:Venditti A; Frezza C; Celona D; Bianco A; Serafini M; Cianfaglione K; Fiorini D; Ferraro S; Maggi F; Lizzi AR; Celenza G
[Ad] Address:Department of Chemistry, La Sapienza University, Rome, Italy.
[Ti] Title:Polar constituents, protection against reactive oxygen species, and nutritional value of Chinese artichoke (Stachys affinis Bunge).
[So] Source:Food Chem;221:473-481, 2017 Apr 15.
[Is] ISSN:0308-8146
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In the present work, we studied the chemical composition of Chinese artichoke (S. affinis tubers) by analyzing its polar constituents and its macro- and micro- nutrients. A total of nine compounds were isolated from the tuber ethanolic extract and structurally elucidated by Nuclear Magnetic Resonance (NMR) spectroscopy and mass spectrometry (MS). The marker compounds identified were oligosaccharide stachyose and the organic acid, succinic acid, as well as phenylethanoid and iridoid glycosides. The macronutrient profile was dominated by carbohydrates (36.9% dw), whereas potassium (2.36%) was the most abundant micro-nutrient. The tuber ethanolic extract was able to efficiently protect human cells (Caco-2, SHSY-5Y and K562) against t-BHP-induced oxidative damage.
[Mh] MeSH terms primary: Iridoid Glycosides/analysis
Plant Extracts/chemistry
Reactive Oxygen Species/analysis
Stachys/chemistry
Succinic Acid/analysis
[Mh] MeSH terms secundary: Caco-2 Cells
Humans
Magnetic Resonance Spectroscopy
Nutritive Value
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Iridoid Glycosides); 0 (Plant Extracts); 0 (Reactive Oxygen Species); AB6MNQ6J6L (Succinic Acid)
[Em] Entry month:1703
[Cu] Class update date: 171003
[Lr] Last revision date:171003
[Js] Journal subset:IM
[Da] Date of entry for processing:161217
[St] Status:MEDLINE

  6 / 172 MEDLINE  
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[PMID]: 27943586
[Au] Autor:Venditti A; Frezza C; Bianco A; Serafini M; Cianfaglione K; Nagy DU; Iannarelli R; Caprioli G; Maggi F
[Ad] Address:Department of Chemistry, University of Rome 'La Sapienza', Piazzale Aldo Moro 5, 00185, Rome, Italy.
[Ti] Title:Polar Constituents, Essential Oil and Antioxidant Activity of Marsh Woundwort (Stachys palustris L.).
[So] Source:Chem Biodivers;14(3), 2017 Mar.
[Is] ISSN:1612-1880
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Stachys palustris, well-known as marsh woundwort, is a perennial herb growing in wet environments of Europe. Its tubers, leaves and seeds are eaten raw or cooked. Alike other Stachys species, the plant is also used as a traditional remedy. Despite S. palustris has been consumed for centuries, little is known about its chemical constituents. In this work the main secondary metabolites of S. palustris from Hungary and France have been analysed. From the plant ethanolic extracts, ethanoid glucosides, isoscutellarein derivatives, caffeoyl-quinic acids and iridoids have been isolated and structurally characterized by NMR. The essential oils were analysed by GC/MS and showed (E)-phytol, fatty acids and carbonylic compounds as the most abundant compounds. The radical scavenging capacity of plant ethanolic extracts, as evaluated by the DPPH assay, was noteworthy, with IC values of 92.08 - 105.42 µg/ml.
[Mh] MeSH terms primary: Antioxidants/chemistry
Oils, Volatile/chemistry
Stachys/chemistry
[Mh] MeSH terms secundary: Gas Chromatography-Mass Spectrometry
Oils, Volatile/analysis
Plant Components, Aerial/chemistry
Plant Components, Aerial/metabolism
Plant Extracts/chemistry
Polyphenols/chemistry
Stachys/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Polyphenols)
[Em] Entry month:1704
[Cu] Class update date: 170410
[Lr] Last revision date:170410
[Js] Journal subset:IM
[Da] Date of entry for processing:161213
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600401

  7 / 172 MEDLINE  
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[PMID]: 27931115
[Au] Autor:Giuliani C; Pellegrino RM; Selvaggi R; Tani C; Tirillini B; Maleci Bini L
[Ad] Address:a Department of Pharmaceutical Sciences , University of Milan , Milan , Italy.
[Ti] Title:Secretory structures and essential oil composition in Stachys officinalis (L.) Trevisan subsp. officinalis (Lamiaceae) from Italy.
[So] Source:Nat Prod Res;31(9):1006-1013, 2017 May.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The secretory structures and the volatile fraction of Stachys officinalis (L.) Trevisan subsp. officinalis (Lamiaceae) from Italy were studied for the first time. Peltate and small capitate trichomes were observed on the whole plant (leaves and inflorescences). In the peltate trichomes, an unusual polyphenols content was evidenced by the histochemical methods. The volatile fraction was obtained by a solvent extract from the distillation water of leaves and inflorescences and analysed by GC-MS. Forty-four constituents for leaves, representing 94.1% of the total volatiles, and 57 compounds for flowers, accounting for 90.1% of the total volatiles, were identified. (E)-caryophyllene (20.1%), (E)-nerolidol (14.3%), caryophyllene oxide (6.1%) and γ-cadinene (5.7%) were recognised as the main constituents for the leaf volatile fraction, while caryophyllene oxide (16.5%), (E)-nerolidol (15.4%), humulene epoxide II (9.2%) and α-pinene (7.0%) were the main compounds for the flower volatile fraction.
[Mh] MeSH terms primary: Oils, Volatile/analysis
Stachys/chemistry
Stachys/ultrastructure
[Mh] MeSH terms secundary: Flowers/chemistry
Gas Chromatography-Mass Spectrometry
Italy
Plant Leaves/chemistry
Trichomes/ultrastructure
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Oils, Volatile)
[Em] Entry month:1706
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:161210
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1261347

  8 / 172 MEDLINE  
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[PMID]: 27927090
[Au] Autor:Ferhat M; Erol E; Beladjila KA; Çetintas Y; Duru ME; Öztürk M; Kabouche A; Kabouche Z
[Ad] Address:a Département de chimie, Laboratoire d'Obtention de Substances Thérapeutiques (LOST) , Université des frères Mentouri-Constantine , Constantine , Algeria.
[Ti] Title:Antioxidant, anticholinesterase and antibacterial activities of Stachys guyoniana and Mentha aquatica.
[So] Source:Pharm Biol;55(1):324-329, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: Stachys guyoniana Noë ex. Batt. and Mentha aquatica L. are two Algerian Lamiaceae used in folk medicine. OBJECTIVE: To investigate their antioxidant, anticholinesterase and antibacterial activities. MATERIAL AND METHODS: n-Butanol (BESG), ethyl acetate (EESG) and chloroform (CESG) extracts of S. guyoniana and methanol (MEMA) and chloroform (CEMA) aerial part extracts of M. aquatica and methanol (MERMA) and acetone (AERMA) roots extracts of M. aquatica were evaluated for their antioxidant activity by the ß-carotene-linoleic acid, DPPH and ABTS scavenging, CUPRAC and metal chelating assays. The anticholinesterase activity was tested against AChE and BChE. The antibacterial activity was assessed by MICs determination against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella heidelberg, Klebsiella pneumoniae, Enterobacter aerogenes and Morganella morganii strains. RESULTS: In the ß-carotene test, the CESG (IC : 2.3 ± 1.27 µg/mL) exhibited the highest activity. The BESG was the best scavenger of DPPH (IC : 2.91 ± 0.14 µg/mL). In the ABTS test, AERMA was the most active (IC : 4.21 ± 0.28 µg/mL). However, with the CUPRAC, the BESG exhibited the best activity (A : 0.15 ± 0.05 µg/mL) and was active in metal chelating assay with 48% inhibition at 100 µg/mL. The BESG was the best AChE inhibitor (IC : 5.78 ± 0.01 µg/mL) however, the AERMA showed the highest BChE inhibitory activity (IC : 19.23 ± 1.42 µg/mL). The tested extracts exhibited a good antibacterial activity. CONCLUSION: This study demonstrated good antioxidant, anticholinesterase and antibacterial potential of S. guyoniana and M. aquatica, which fits in well with their use in folk medicine.
[Mh] MeSH terms primary: Anti-Bacterial Agents/pharmacology
Antioxidants/pharmacology
Bacteria/drug effects
Cholinesterase Inhibitors/pharmacology
Mentha/chemistry
Plant Extracts/pharmacology
Stachys/chemistry
[Mh] MeSH terms secundary: Acetylcholinesterase/metabolism
Anti-Bacterial Agents/isolation & purification
Antioxidants/isolation & purification
Bacteria/growth & development
Benzothiazoles/chemistry
Biphenyl Compounds/chemistry
Butyrylcholinesterase/metabolism
Chelating Agents/isolation & purification
Chelating Agents/pharmacology
Chlorides/chemistry
Cholinesterase Inhibitors/isolation & purification
Copper/chemistry
Ferric Compounds/chemistry
Linoleic Acid/chemistry
Microbial Sensitivity Tests
Oxidation-Reduction
Phytotherapy
Picrates/chemistry
Plant Components, Aerial
Plant Extracts/isolation & purification
Plants, Medicinal
Solvents/chemistry
Sulfonic Acids/chemistry
beta Carotene/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Chelating Agents); 0 (Chlorides); 0 (Cholinesterase Inhibitors); 0 (Ferric Compounds); 0 (Picrates); 0 (Plant Extracts); 0 (Solvents); 0 (Sulfonic Acids); 01YAE03M7J (beta Carotene); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); 789U1901C5 (Copper); 9KJL21T0QJ (Linoleic Acid); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase); U38V3ZVV3V (ferric chloride)
[Em] Entry month:1703
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:161209
[St] Status:MEDLINE

  9 / 172 MEDLINE  
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[PMID]: 27707007
[Au] Autor:Rahimi Khoigani S; Rajaei A; Goli SA
[Ad] Address:a Faculty of Agriculture , Shahrood University of Technology , Shahrood , Iran.
[Ti] Title:Evaluation of antioxidant activity, total phenolics, total flavonoids and LC-MS/MS characterisation of phenolic constituents in Stachys lavandulifolia.
[So] Source:Nat Prod Res;31(3):355-358, 2017 Feb.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The aim of this study was to evaluate phenolics profile and antioxidant activity of Stachys lavandulifolia. Total phenolics (TP), total flavonoids (TF), DPPH• assay (IC50), ferric ion reducing antioxidant power (FRAP) and total antioxidant capacity (TAC) of the methanolic extract were measured. The content of TP, TF, IC50, FRAP and TAC, were obtained as 16.59 gallic acid equiv./g dry matter (DM), 4.48 mg quercetin equiv./g DM, 2.07 (µg/mL), 0.014 (absorbance/mg phenolic) and 14.61 (mg BHT equiv./g DM), respectively. The results showed that S. lavandulifolia, compared to other species of Stachys, had moderate TP content with desirable antioxidant activity. Subsequently, 59 various phenolic compounds were identified and confirmed in the methanolic extract of S. lavandulifolia using high mass accuracy by MS2 experiments. The compounds consisted of 6 hydroxybenzoic acids and hydroxybenzoic aldehydes, 9 hydroxycinnamic acids, 1 coumarin, 32 flavonoids, 3 lignans, 2 stilbenes, 3 tannins and 3 other phenolics.
[Mh] MeSH terms primary: Antioxidants/chemistry
Flavonoids/chemistry
Phenols/chemistry
Stachys/chemistry
Tandem Mass Spectrometry/methods
[Mh] MeSH terms secundary: Gallic Acid/chemistry
Hydroxybenzoates/analysis
Plant Extracts/analysis
Plant Extracts/chemistry
Quercetin/chemistry
Tannins/analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antioxidants); 0 (Flavonoids); 0 (Hydroxybenzoates); 0 (Phenols); 0 (Plant Extracts); 0 (Tannins); 632XD903SP (Gallic Acid); 9IKM0I5T1E (Quercetin)
[Em] Entry month:1704
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:161007
[St] Status:MEDLINE

  10 / 172 MEDLINE  
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[PMID]: 27399832
[Au] Autor:Ramazanov NS; Bobayev ID; Yusupova UY; Aliyeva NK; Egamova FR; Yuldasheva NK; Syrov VN
[Ad] Address:a Institute of the Chemistry of Plant Substances , Academy of Sciences of Uzbekistan , Tashkent , Uzbekistan.
[Ti] Title:Phytoecdysteroids-containing extract from Stachys hissarica plant and its wound-healing activity.
[So] Source:Nat Prod Res;31(5):593-597, 2017 Mar.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A number of phytoecdysteroid compounds, such as ecdysterone, polipodin V, 2-deoxy-20-hydroxyecdysone, integristeron A and 2-deoxydizon were isolated from Stachys hissarica plant and their structures were confirmed by NMR, mass and IR spectroscopy. In addition, the biological activity of the S. hissarica plant's extract was tested on rats for wound healing activity. It was shown that the extract at repeated oral (per os) administration at a dose of 10 mg/kg speeds up the healing process of linear skin wounds in rats. The wound-healing activity of S. hissarica extract is confirmed to be effective and exceeds known drug methyluracil (2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine), especially in case of alloxan induced diabetic animals.
[Mh] MeSH terms primary: Ecdysteroids/pharmacology
Plant Extracts/pharmacology
Stachys/chemistry
Wound Healing/drug effects
[Mh] MeSH terms secundary: Alloxan
Animals
Diabetes Mellitus, Experimental/physiopathology
Plant Extracts/analysis
Rats
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Ecdysteroids); 0 (Plant Extracts); 6SW5YHA5NG (Alloxan)
[Em] Entry month:1704
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:160712
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1205058


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