Database : MEDLINE
Search on : staphylococcal and scalded and skin and syndrome [Words]
References found : 677 [refine]
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[PMID]: 29508362
[Au] Autor:Leung AKC; Barankin B; Leong KF
[Ad] Address:Department of Pediatrics, The Alberta Children's Hospital, The University of Calgary, Calgary, #200, 233-16th Avenue NW, Calgary, AB, T2M 0H5, Canada. aleung@ucalgary.ca.
[Ti] Title:Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management.
[So] Source:World J Pediatr;, 2018 Mar 05.
[Is] ISSN:1867-0687
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Staphylococcal-scalded skin syndrome (SSSS), also known as Ritter disease, is a potentially life-threatening disorder and a pediatric emergency. Early diagnosis and treatment is imperative to reduce the morbidity and mortality of this condition. The purpose of this article is to familiarize physicians with the evaluation, diagnosis, and treatment of SSSS. DATA SOURCES: A PubMed search was completed in Clinical Queries using the key terms "Staphylococcal scalded skin syndrome" and "Ritter disease". RESULTS: SSSS is caused by toxigenic strains of Staphylococcus aureus. Hydrolysis of the amino-terminal extracellular domain of desmoglein 1 by staphylococcal exfoliative toxins results in disruption of keratinocytes adhesion and cleavage within the stratum granulosum which leads to bulla formation. The diagnosis is mainly clinical, based on the findings of tender erythroderma, bullae, and desquamation with a scalded appearance especially in friction zones, periorificial scabs/crusting, positive Nikolsky sign, and absence of mucosal involvement. Prompt empiric treatment with intravenous anti-staphylococcal antibiotic such as nafcillin, oxacillin, or flucloxacillin is essential until cultures are available to guide therapy. Clarithromycin or cefuroxime may be used should the patient have penicillin allergy. If the patient is not improving, critically ill, or in communities where the prevalence of methicillin-resistant S. aureus is high, vancomycin should be used. CONCLUSION: A high index of suspicion is essential for an accurate diagnosis to be made and treatment promptly initiated.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1007/s12519-018-0150-x

  2 / 677 MEDLINE  
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[PMID]: 29248323
[Au] Autor:Ajmi H; Jemmali N; Mabrouk S; Hassayoun S; Ben-Ali M; Barbouche MR; Mokni M; Abroug S
[Ad] Address:Department of pediatrics, Sahloul University Hospital, 4054, Sousse Tunisia. Electronic address: hd.ajmi@gmail.com.
[Ti] Title:Staphylococcal scalded skin syndrome: An uncommon symptomatology revealing an immune deficiency.
[So] Source:Arch Pediatr;25(2):126-128, 2018 Feb.
[Is] ISSN:1769-664X
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Primary immune deficiencies associated with hyper-IgE syndrome are rare diseases with clinical features dominated by recurring cutaneous and visceral bacterial infections, particularly infections due to Staphylococcus species. Most of these infections are associated with milder inflammation compared to normal. We report a primary immune deficiency associated with a hyper-IgE syndrome revealed by a staphylococcal scalded skin syndrome in a 5-year-old girl. The patient presented with a severe staphylococcal infection with extensive skin lesions and disseminated intravascular coagulation. She received intravenous fluids to compensate for fluid losses and anti-staphylococcal antibiotics. Coagulopathy was also corrected. However, the progression was rapidly fatal.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180221
[Lr] Last revision date:180221
[St] Status:In-Process

  3 / 677 MEDLINE  
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[PMID]: 29378637
[Au] Autor:Haasnoot PJ; De Vries A
[Ad] Address:Department of Surgery, Burns unit, Rode Kruis Hospital, Beverwijk, Vondellaan 13, 1942LE, Beverwijk, The Netherlands. phaasnoot@rkz.nl.
[Ti] Title:Staphylococcal scalded skin syndrome in a 4-year-old child: a case report.
[So] Source:J Med Case Rep;12(1):20, 2018 Jan 29.
[Is] ISSN:1752-1947
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Staphylococcal scalded skin syndrome is an exfoliating skin disease which primarily affects children. Differential diagnosis includes toxic epidermal necrolysis, staphylococcal scalded skin syndrome, epidermolysis bullosa, and Stevens-Johnson syndrome. Staphylococcal scalded skin syndrome primarily affects children and can cause serious morbidity. CASE PRESENTATION: In this case report we highlight the case of a 4-year-old Caucasian boy. Diagnostic and therapeutic challenges are discussed. Differential diagnoses are considered and therapy is described and discussed. The latest treatment options are used and described. Successful results are achieved in this case due to timely and correct management. CONCLUSIONS: Some therapeutic options are widely used without thorough research bases. This case report highlights staphylococcal scalded skin syndrome and its treatment, and future challenges. Further research is warranted and this case report aims to further research in exfoliating skin disorders.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[St] Status:In-Process
[do] DOI:10.1186/s13256-017-1533-7

  4 / 677 MEDLINE  
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[PMID]: 29336047
[Au] Autor:Maguire CA; Chong H; Ramachandran R; Popoola J; Akhras V; Singh M
[Ad] Address:Department of Dermatology, St George's Healthcare NHS Trust, London, UK.
[Ti] Title:Acrodermatitis acidaemica.
[So] Source:Clin Exp Dermatol;, 2018 Jan 15.
[Is] ISSN:1365-2230
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Methylmalonic acidaemia (MMA) is an inborn error of amino acid metabolism that may be associated with cutaneous manifestations mimicking other diagnoses, including staphylococcal scalded skin syndrome (SSSS), psoriasis and acrodermatitis enteropathica. Whether this is due to the underlying metabolic disorder itself or occurs as a consequence of dietary restriction has yet to be elucidated. Skin biopsies typically show histological features shared by a number of other metabolic disorders and nutritional deficiency-associated diseases. Some presentations, especially SSSS-like eruptions, may be associated with acute metabolic decompensation. An underlying metabolic disorder, such as MMA, should be considered in a diagnosed adult or undiagnosed child presenting with skin eruptions that resemble those listed above, so that specialist management may be initiated early.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180116
[Lr] Last revision date:180116
[St] Status:Publisher
[do] DOI:10.1111/ced.13369

  5 / 677 MEDLINE  
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[PMID]: 29332709
[Au] Autor:Arnold JD; Hoek SN; Kirkorian AY
[Ad] Address:George Washington University School of Medicine and Health Sciences, Washington, District of Columbia. Electronic address: jarnold@gwu.edu.
[Ti] Title:Epidemiology of staphylococcal scalded skin syndrome in the United States: A cross-sectional study, 2010-2014.
[So] Source:J Am Acad Dermatol;78(2):404-406, 2018 Feb.
[Is] ISSN:1097-6787
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180115
[Lr] Last revision date:180115
[St] Status:In-Data-Review

  6 / 677 MEDLINE  
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[PMID]: 29110142
[Au] Autor:Pimentel de Araujo F; Tinelli M; Battisti A; Ercoli A; Anesi A; Pantosti A; Monaco M
[Ad] Address:Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
[Ti] Title:An outbreak of skin infections in neonates due to a Staphylococcus aureus strain producing the exfoliative toxin A.
[So] Source:Infection;, 2017 Nov 06.
[Is] ISSN:1439-0973
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: Staphylococcus aureus is an important cause of infections in hospitalized neonates. Preterm or low birthweight infants are especially at risk to develop a S. aureus infection due to the immaturity of the immune system, length of hospital stay and invasive procedures. Exfoliative toxin (ET)-producing S. aureus is often responsible for neonatal infections, causing clinical manifestations such as staphylococcal scalded skin syndrome, characterized by both localized blisters or generalized exfoliation of the skin. METHODS: We describe an outbreak due to an S. aureus strain producing ETA occurring in a local hospital in Northern Italy. Molecular typing of the isolates included spa typing and multilocus sequence typing. DNA microarray hybridization was also performed on one representative strain. RESULTS: In the period from July 2013 to February 2014, 12 neonates presented with skin infections, mainly bullae or pustules. Cultures of skin swabs yielded methicillin-susceptible S. aureus (MSSA). By molecular typing, an epidemic strain (t1393/ST5) was identified in nine neonates; microarray analysis and PCR revealed that it contained the ETA encoding gene. Screening of staff, mothers and healthy neonates and environmental cultures did not reveal the presence of the epidemic strain. However, the father of an infected neonate was found to be a carrier of MSSA t1393 five months after the outbreak started. CONCLUSION: Implementation of hygiene procedures and sanitization of the ward twice terminated the outbreak. Timely surveillance of infections, supported by molecular typing, is fundamental to prevent similar episodes among neonates.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[St] Status:Publisher
[do] DOI:10.1007/s15010-017-1084-2

  7 / 677 MEDLINE  
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[PMID]: 29077993
[Au] Autor:Staiman A; Hsu DY; Silverberg JI
[Ad] Address:Department of Dermatology, Feinberg School of Medicine at, Northwestern University, Chicago, IL, USA.
[Ti] Title:Epidemiology of Staphylococcal Scalded Skin Syndrome in United States Children.
[So] Source:Br J Dermatol;, 2017 Oct 27.
[Is] ISSN:1365-2133
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Staphylococcal scalded skin syndrome (SSSS) is a blistering dermatosis caused by exfoliative toxins released from Staphylococcus aureus. We sought to describe the incidence, costs, length of stay (LOS), comorbidities, and mortality of SSSS in US children. METHODS: The Nationwide Inpatient Sample 2008-2012 was analyzed, including a 20% sample of US hospitalizations and 589 cases of SSSS. RESULTS: The annual incidence of SSSS was 7.67 (range: 1.83-11.88) per-million US children, with 45.1 cases per-million US infants age <2 years. In multivariate logistic regression models, SSSS was significantly associated with female sex (adjusted odds ratio [95% confidence interval]:1.12 [1.00-1.25]), age (2-5yr:13.31 [11.82-14.99], 6-10yr:2.93 [2.35-3.66], 11-17yr:0.44 [0.31-0.63]), race/ethnicity (blacks:0.69 [0.58-0.84]), season (winter:2.04 [1.66-2.50], summer:3.47 [2.86-4.22], fall:3.04 [2.49-3.70]), with increasing odds over time (2010-2011:2.28 [2.07-2.51], 2012:2.98 [2.69-3.30]). The geometric mean (95% CI) LOS and cost of hospitalization for patients with vs. without SSSS was 3.2 (3.0-3.4) vs. 2.4 (2.4-2.5) days and $4,624.0 [$4,250.8-$5,030.1] vs. $1,871.7 [$1,782.7-$1,965.1]. Crude inpatient mortality rates were similar for children with vs. without SSSS (0.33% [0.00-0.79%] vs. 0.36% [0.34-0.39%]). SSSS was associated with other infections, including in upper respiratory tract and skin. CONCLUSIONS: SSSS prevalence appears to be increasing over time, and was associated with a number of socio-demographic factors and other infections. Further studies are needed to confirm these findings and reduce rising rates of SSSS. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171027
[Lr] Last revision date:171027
[St] Status:Publisher
[do] DOI:10.1111/bjd.16097

  8 / 677 MEDLINE  
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[PMID]: 28853493
[Au] Autor:Saluzzo S; Layer F; Stingl G; Stary G
[Ad] Address:Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, AT-1090 Vienna, Austria. simona.saluzzo@meduniwien.ac.at.
[Ti] Title:Staphylococcal Scalded Skin Syndrome Caused by a Rare Variant of Exfoliative-toxin-A + S. aureus in an Adult Immunocompromised Woman.
[So] Source:Acta Derm Venereol;, 2017 Aug 30.
[Is] ISSN:1651-2057
[Cp] Country of publication:Sweden
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170907
[Lr] Last revision date:170907
[St] Status:Publisher
[do] DOI:10.2340/00015555-2778

  9 / 677 MEDLINE  
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[PMID]: 28815266
[Au] Autor:Urata T; Kono M; Ishihara Y; Akiyama M
[Ad] Address:Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
[Ti] Title:Adult Staphylococcal Scalded Skin Syndrome Successfully Treated with Multimodal Therapy Including Intravenous Immunoglobulin.
[So] Source:Acta Derm Venereol;, 2017 Aug 17.
[Is] ISSN:1651-2057
[Cp] Country of publication:Sweden
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[St] Status:Publisher
[do] DOI:10.2340/00015555-2770

  10 / 677 MEDLINE  
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[PMID]: 28674637
[Au] Autor:Davidson J; Polly S; Hayes PJ; Fisher KR; Talati AJ; Patel T
[Ad] Address:Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
[Ti] Title:Recurrent Staphylococcal Scalded Skin Syndrome in an Extremely Low-Birth-Weight Neonate.
[So] Source:AJP Rep;7(2):e134-e137, 2017 Apr.
[Is] ISSN:2157-6998
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Staphylococcal scalded skin syndrome (SSSS) in premature infants is a rare condition. We present SSSS in an extremely low-birth-weight (ELBW) infant with recurrent and confirmed bacterial sepsis. We present it to emphasize the importance for clinicians to not only recognize the clinical manifestations of SSSS, but also the need to closely monitor infants, especially very low-birth-weight (VLBW) and ELBW infants with SSSS for recurrence and bacterial sepsis. SSSS in preterm infants is a potentially lethal condition and early recognition and appropriate supportive care could be life-saving.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170706
[Lr] Last revision date:170706
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1055/s-0037-1603971


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