Database : MEDLINE
Search on : struma and ovarii [Words]
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[PMID]: 29459090
[Au] Autor:Lebreton C; Al Ghuzlan A; Floquet A; Kind M; Leboulleux S; Godbert Y
[Ad] Address:Institut Bergonié, département d'oncologie médicale, 229, cours de l'Argonne, 33076 Bordeaux, France. Electronic address: c.lebreton@bordeaux.unicancer.fr.
[Ti] Title:Cancer thyroïdien sur struma ovarii : généralités et principes de prise en charge. [Thyroid carcinoma on struma ovarii: Diagnosis and treatment].
[So] Source:Bull Cancer;, 2018 Feb 16.
[Is] ISSN:1769-6917
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumour, derivate from monodermic teratomas. It represents about 0.01% of overall ovarian tumours and 5 to 10% of struma ovarii. The diagnosis is histologic and retrospective after pelvic surgery; radiographic imaging being unspecific. Because of its rarity, the treatment of TCSO is not consensual and should be validated in multidisciplinary team involved in rare ovarian carcinoma. The first treatment is a surgical removal, with a laparoscopic approach. A fertility-conservative surgery is recommended for young women. If the tumour is unresectable and/or with metastatic spread, an adjuvant iodine 131 treatment might be proposed after thyroidectomy. Recurrence of TCSO should be taken care of as a thyroid carcinoma with tyrosine kinase inhibitor in case of progressive distant relapse, refractory to iodine 131 treatment. If the recurrence is localised, a complete surgery is the preferred option. There is no gold standard for the follow up.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher

  2 / 583 MEDLINE  
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[PMID]: 29455317
[Au] Autor:Kato N; Sakamoto K; Murakami K; Iwasaki Y; Kamataki A; Kurose A
[Ad] Address:Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki, 036-8562, Japan. nor-kato@hirosaki-u.ac.jp.
[Ti] Title:Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids.
[So] Source:Virchows Arch;, 2018 Feb 17.
[Is] ISSN:1432-2307
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Although ovarian monodermal teratomas, including struma ovarii and carcinoids, are closely associated with mature teratomas, their genetic basis is poorly understood. A series of mature and monodermal ovarian teratomas were analyzed by short tandem repeat genotyping to evaluate their genetic zygosity and its associations. Informative DNA genotyping data were obtained for ten mature teratomas, six struma ovarii, and three carcinoids (one insular, one trabecular, and one mucinous). A homozygous genotype was present in five of the ten (50%) mature teratomas, three of the six (50%) struma ovarii, and one of the three (33%) ovarian carcinoids. There was no significant difference in genetic zygosity between mature and monodermal teratomas. Patients' age was not correlated with the genetic zygosity: the youngest age in the homozygous tumor group of patients was 4 years. It is suggested that an oocyte after meiosis I, which has escaped from meiotic arrest, is a significant cause of these tumors. Although one mature teratoma was a rare case with lactating adenoma-like breast tissue, its genetic zygosity was concordant with that of the surrounding teratomatous tissue. In one ovarian carcinoid, the carcinoid and accompanying teratomatous components showed matching zygosity at all but one locus: the carcinoid was heterozygous but teratoma was homozygous at one pericentromeric locus. This suggests that not all carcinoids are secondary neoplasms arising from a fully developed mature teratoma: some are neoplasms deviating from a developing mature teratoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180218
[Lr] Last revision date:180218
[St] Status:Publisher
[do] DOI:10.1007/s00428-018-2319-z

  3 / 583 MEDLINE  
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[PMID]: 29391043
[Au] Autor:Fujiwara S; Tsuyoshi H; Nishimura T; Takahashi N; Yoshida Y
[Ad] Address:Department of Obstetrics and Gynecology, Kizawa Memorial Hospital, 590 Shimokobi, Kobi-cho, Minokamo-shi, Gifu, 505-8503, Japan.
[Ti] Title:Precise preoperative diagnosis of struma ovarii with pseudo-Meigs' syndrome mimicking ovarian cancer with the combination of I scintigraphy and F-FDG PET: case report and review of the literature.
[So] Source:J Ovarian Res;11(1):11, 2018 Feb 02.
[Is] ISSN:1757-2215
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Struma ovarii is a rare ovarian neoplasm that often appears malignant on conventional imaging. Pseudo-Meigs' syndrome with ascites, pleural effusion, and elevated serum CA 125 levels is much rarer and leads to misdiagnosis of ovarian cancer and unnecessary extended surgery. CASE PRESENTATION: A 50-year-old woman with abdominal distention and dyspnoea was referred to our hospital. Ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) showed a polycystic ovarian tumor with a solid component, pleural effusion, and massive ascites with negative cytology. Her serum CA 125 level was 1237 U/ml, indicating the presence of ovarian cancer. Based on increased uptake of I but no uptake of F-FDG in the tumor, the preoperative diagnosis was struma ovarii with pseudo-Meigs' syndrome, which was confirmed histologically. She had no evidence of ascites and pleural effusion six months after surgery. CONCLUSIONS: To date, there have been no systematic reviews focused on preoperative diagnosis with imaging modalities. The combination of I scintigraphy and F-FDG PET/CT in addition to conventional imaging modalities can provide the precise preoperative diagnosis of struma ovarii with pseudo-Meigs' syndrome mimicking ovarian cancer, leading to the appropriate treatment strategy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:In-Process
[do] DOI:10.1186/s13048-018-0383-2

  4 / 583 MEDLINE  
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[PMID]: 29223697
[Au] Autor:Hwang JY; Lee MH; Lee JH; Kim DH; Song SH
[Ad] Address:Department of Obstetrics and Gynecology, CHA Gumi Medical Center and Comprehensive Gynecologic Cancer Center, Seoul, Republic of Korea.
[Ti] Title:A Case of Unilateral Endometriosis Coexisting with Struma Ovarii in Bilateral Ovarian Teratoma.
[So] Source:J Minim Invasive Gynecol;, 2017 Dec 06.
[Is] ISSN:1553-4669
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180123
[Lr] Last revision date:180123
[St] Status:Publisher

  5 / 583 MEDLINE  
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[PMID]: 29360077
[Au] Autor:Pastorino Casas V; Borghi Torzillo MF; Schere D; Lutfi RJ; Faure EN
[Ad] Address:Servicio de Endocrinología, Servicio de Endocrinología y Metabolismo, Complejo Médico Churruca-Visca, Buenos Aires, Argentina.
[Ti] Title:Estruma ovárico asociado con enfermedad de Graves. [Struma ovarii associated with Graves' disease].
[So] Source:Medicina (B Aires);78(1):44-46, 2018.
[Is] ISSN:0025-7680
[Cp] Country of publication:Argentina
[La] Language:spa
[Ab] Abstract:Hyperthyroidism is defined as an excessive production of thyroid hormones by eutopic or ectopic mature thyroid tissue. The overall prevalence of hyperthyroidism is 1.2% and the most common cause is Graves' disease. Struma ovarii represents 1% of all ovarian tumors and is an uncommon cause of ectopic hyperthyroidism. It is benign in >90% of the cases; usually asymptomatic, and only 8% are presented with thyrotoxicosis, being rare its association with Graves' disease. We report the case of a patient with this association.
[Pt] Publication type:CASE REPORTS; ENGLISH ABSTRACT
[Em] Entry month:1801
[Cu] Class update date: 180123
[Lr] Last revision date:180123
[St] Status:In-Data-Review

  6 / 583 MEDLINE  
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[PMID]: 29318892
[Au] Autor:Fabbri R; Vicenti R; Paradisi R; Rossi S; De Meis L; Seracchioli R; Macciocca M
[Ad] Address:a Gynecology and Physiopathology of Human Reproductive Unit , University of Bologna, S. Orsola-Malpighi Hospital of Bologna , Bologna , Italy.
[Ti] Title:Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis.
[So] Source:Gynecol Endocrinol;:1-5, 2018 Jan 10.
[Is] ISSN:1473-0766
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In this case report, the outcomes of cryopreserved ovarian tissue transplantation performed in a patient affected by struma-ovarii associated with mature cystic teratoma, recurrent endometriotic cysts and diffuse peritoneal malignant struma-ovarii implants were described. Before cryopreservation, the patient underwent two left ovarian surgeries for enucleation cysts 8 years after righ salpingo-oophorectomy for struma-ovarii. Ovarian biopsy was collected in another hospital and transported to our laboratory for cryopreservation. The patient was submitted to radioiodine-therapy for metastases from malignant struma-ovarii. After treatment she experienced premature ovarian failure. Ten years after cryopreservation, a first orthotopic transplantation was performed in the left ovary and in a peritoneal pocket. Before transplantation, ovarian samples were analyzed to assess neoplastic contamination and tissue quality. Three years later, a second transplantation was heterotopically performed in abdominal subcutaneous sites. The analysis on thawed ovarian tissue did not reveal micrometastasis and they showed follicle and stroma damages. After transplantation few small follicles were observed at ultrasound examination and hormonal levels remained at menopausal values. To date no ovarian function recovery has been observed. The report highlights that ovarian tissue cryopreservation after multiple ovarian surgery may have some limitations. An accurate counseling should be offered to patients who wish to preserve fertility.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180110
[Lr] Last revision date:180110
[St] Status:Publisher
[do] DOI:10.1080/09513590.2017.1423468

  7 / 583 MEDLINE  
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[PMID]: 29299099
[Au] Autor:Gil R; Cunha TM; Rolim I
[Ad] Address:Serviço de Radiologia, Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.
[Ti] Title:Mature cystic teratoma with high proportion of solid thyroid tissue: a controversial case with unusual imaging findings.
[So] Source:J Radiol Case Rep;11(7):20-30, 2017 Jul.
[Is] ISSN:1943-0922
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We describe a case of a mature cystic teratoma of the ovary with high proportion of solid thyroid tissue (< 50% of the entire tumor) in a childbearing woman. The patient presented with non-specific abdominal bloating. Pelvic ultrasound and magnetic resonance imaging revealed a complex cystic-solid tumor confined to the left ovary with an anterior fat-containing locus compatible with mature cystic teratoma and a posterior predominantly solid component with low signal intensity on T2-weighted images that was histopatologically diagnosed as benign thyroid tissue. Thyroglobulin levels were in normal range. Although thyroid tissue is present in up to 20% of mature cystic teratomas, with exception of struma ovarii, it is not usually macroscopically nor radiologically identified. The differential diagnosis should include T2-hypointense adnexal lesions associated with mature cystic teratoma, malignant transformation of mature teratoma, and immature teratoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180107
[Lr] Last revision date:180107
[St] Status:In-Process
[do] DOI:10.3941/jrcr.v11i7.2853

  8 / 583 MEDLINE  
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[PMID]: 29286966
[Au] Autor:Comunello J; Eloi Pinto FF; Nakagawa SA; Tu Chung W; D'Almeida Costa F; Brilhante AD
[Ad] Address:Departments of Orthopaedic Oncology (J.C., F.F.E.P., S.A.N., and W.T.C.), and Pathological Anatomy (F.D.C. and A.D.B.), AC Camargo Cancer Center, São Paulo, Brazil.
[Ti] Title:Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report.
[So] Source:JBJS Case Connect;7(4):e82, 2017 Oct-Dec.
[Is] ISSN:2160-3251
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:CASE: We report the case of a 38-year-old woman who presented with a lytic bone lesion in the left scapula. A biopsy showed a tumor with the histologic appearance of thyroid tissue. She also was found to have a thyroid nodule and an enlarged ovary, both of which were excised. The thyroid nodule turned out to be a benign colloid nodule, and the ovary contained a monodermal teratoma composed of thyroid tissue (struma ovarii). The lesion in the scapula eventually was proven to be metastatic malignant struma ovarii. CONCLUSION: Malignant struma ovarii with bone metastases is very rare, and its diagnosis is a challenge. There are some documented cases with bone metastases, mostly to the thoracic and lumbar spine. The optimal treatment of choice for the bone lesion is unknown because of the rarity of its presentation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171229
[Lr] Last revision date:171229
[St] Status:In-Data-Review
[do] DOI:10.2106/JBJS.CC.16.00262

  9 / 583 MEDLINE  
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[PMID]: 29278520
[Au] Autor:Gobitti C; Sindoni A; Bampo C; Baresic T; Giorda G; Alessandrini L; Canzonieri V; Franchin G; Borsatti E
[Ad] Address:Division of Radiotherapy, Centro di Riferimento Oncologico, IRCCS-National Cancer Institute, Aviano, PN Italy.
[Ti] Title:Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature.
[So] Source:Hormones (Athens);16(3):322-327, 2017 Jul.
[Is] ISSN:1109-3099
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Struma ovarii (SO), a rare tumor containing at least 50% of thyroid tissue, represents approximately 5% of all ovarian teratomas; its malignant transformation rate is reported to occur in up to 10% of cases and metastases occur in about 5-6% of them. We describe a 36-year old woman who underwent laparoscopic left annessectomy two years earlier because of an ovarian cyst. Follow-up imaging revealed a right adnexal mass, ascitis and peritoneal nodes that were diagnosed as comprising a malignant SO with peritoneal secondary localizations at histopathology performed after intervention. Restaging with 18F-FDG-PET/CT scan, abdominal CT and ultrasonography showed abnormalities in the perihepatic region and presacral space and left hypochondrium localizations. The patient underwent thyroidectomy, hepatic nodulectomy and cytoreductive peritonectomy: histopathological examination did not show any malignant disease in the thyroid and confirmed the presence of peritoneal localizations due to malignant SO; molecular analysis detected NRAS Q61K mutation in exon 3, whereas no mutations were identified on the BRAF gene. The patient underwent radioiodine treatment: serum Tg was decreased at first follow-up after three months of 131I-therapy. We believe that our case raises some interesting considerations. First, pathologists should be aware of this entity and should check for the presence of point mutations suggesting an aggressive disease behavior, which could be beneficial for an optimal therapeutic approach. Second, although most of the knowledge in this field comes from case reports, efforts should be made to standardize the management of patients affected by malignant SO, including use of practice guidelines.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171226
[Lr] Last revision date:171226
[St] Status:In-Process
[do] DOI:10.14310/horm.2002.1750

  10 / 583 MEDLINE  
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[PMID]: 29250686
[Au] Autor:Ciobanu Apostol DG; BuTureanu TA; Socolov DG; Scripcaru DC; Rosin OL; Lozneanu L
[Ad] Address:Department of Obstetrics and Gynecology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania; tudorandreib@gmail.com.
[Ti] Title:Ovarian strumal carcinoid - case report.
[So] Source:Rom J Morphol Embryol;58(3):1035-1040, 2017.
[Is] ISSN:1220-0522
[Cp] Country of publication:Romania
[La] Language:eng
[Ab] Abstract:Strumal carcinoid represents a rare form of ovarian teratoma, consisting of both thyroid tissue and carcinoid structures. The carcinoid component is a well-differentiated neuroendocrine tumor with excellent prognosis. Strumal carcinoid tumors are commonly found in peri-menopausal women who are not usually interested in preserving their fertility and who are thus open to radical surgical treatment. In this report, we present a 24-year-old, nulliparous patient with strumal carcinoid, confirmed by histopathology and a large panel of immunohistochemistry (IHC) markers, who wished to preserve her fertility. In this case, a conservative surgical treatment (salpingo-oophorectomy) served to preserve vital and reproductive prognosis, and correct tumor classification was of extreme importance. The morphological examination of strumal carcinoid showed struma ovarii with a thyroid follicle-like structure [positive for thyroid transcription factor 1 (TTF1), thyroglobulin, CD56, cytokeratin (CK) 19, and negative for Hector Battifora and mesothelioma 1 (HBME1)], and a neuroendocrine cell component with a trabecular arrangement and island growth (positive for synaptophysin, chromogranin, CD56, and CK7 negative), which were interlocked and intimately associated. Papillary thyroid carcinoma of follicular type was ruled out by CD56 positivity and HBME1 negativity. Medullary thyroid carcinoma with strumal component was excluded by calcitonin negative staining. Solid rosette-like structures with negative glial fibrillary acidic protein (GFAP) staining ruled out a neuroectodermal component. A multilocular mucinous cystadenoma was identified without other teratoma components. Strumal carcinoid requires a meticulous examination to rule out other entities with malignant behavior and poor prognosis. In this case, a conservative treatment is sufficient to remove the tumor, preserving vital and reproductive prognosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171218
[Lr] Last revision date:171218
[St] Status:In-Process


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