Database : MEDLINE
Search on : submandibular and gland and diseases [Words]
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[PMID]: 29381959
[Au] Autor:Wu PC; Tien PT; Li YH; Chen RY; Cho DY
[Ad] Address:Division of Rheumatology and Immunology, Department of Internal Medicine, China Medical University Hospital.
[Ti] Title:IgG4-related cerebral pseudotumor with perineural spreading along branches of the trigeminal nerves causing compressive optic neuropathy: A case report.
[So] Source:Medicine (Baltimore);96(47):e8709, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Immunoglobulin G4-related disease (IgG4-RD) is characterized by tumor-like lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis. IgG4-RD has been described in a variety of organ systems; however, it rarely involves the central nervous system. PATIENT CONCERNS: A 17-year-old woman visited our clinic with a complaint of blurred vision for the past 5 months. She also reported a painless right submandibular mass that had been present for 1 year. Her best-corrected visual acuity (BCVA) was 2.0 LogMAR, with an almost total visual field defect in the right eye. DIAGNOSES: Magnetic resonance imaging (MRI) revealed lobulated parasellar tumors with perineural spreading along branches of the trigeminal nerves causing right optic nerve compression. A craniotomy with tumor removal and submandibular gland biopsy was performed. Histopathological analysis of the tumor revealed stromal fibrosis with atypical lymphoid infiltrations. Histopathological and immunohistochemical analysis of the submandibular gland confirmed the diagnosis of IgG4-RD. INTERVENTIONS: The patient was administered 500mg/d of pulse methylprednisolone for 3 days, 500mg of intravenous rituximab every 2 weeks (for a total of 2 doses), and 500mg of intravenous pulse cyclophosphamide every month (for a total of 3 doses). OUTCOMES: Two months after the initiation of immunosuppressive therapy, the patient's BCVA returned to 0.1 LogMAR with visual field defect recovery. The follow-up MRI showed the almost complete disappearance of the previously contrast-enhanced lesions. LESSONS: Herein, we report a rare case of IgG4-RD presenting as a parasellar tumor and present a review of the related literature. Based on the case report, we propose that aggressive therapy with glucocorticoid, rituximab, and cyclophosphamide may potentially be useful for treating such cases.
[Mh] MeSH terms primary: Immunoglobulin G/immunology
Optic Nerve Diseases/immunology
Pseudotumor Cerebri/immunology
Trigeminal Nerve/pathology
[Mh] MeSH terms secundary: Adolescent
Female
Humans
Magnetic Resonance Imaging
Methylprednisolone/therapeutic use
Optic Nerve Diseases/drug therapy
Optic Nerve Diseases/surgery
Pseudotumor Cerebri/drug therapy
Pseudotumor Cerebri/surgery
Rituximab/therapeutic use
Submandibular Gland/pathology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Immunoglobulin G); 4F4X42SYQ6 (Rituximab); X4W7ZR7023 (Methylprednisolone)
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008709

  2 / 2598 MEDLINE  
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[PMID]: 27777501
[Au] Autor:Hawley D; Aluri H; Armaos H; Kim G; Kublin C; Zoukhri D
[Ad] Address:Department of Comprehensive Care, Tufts University School of Dental Medicine, Boston, MA.
[Ti] Title:Human postmortem lacrimal and submandibular glands stored in RNA are suitable for molecular, biochemical, and cell biological studies.
[So] Source:Mol Vis;22:1221-1228, 2016.
[Is] ISSN:1090-0535
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Gene expression and protein analysis studies require high-quality human tissue which is a challenge and difficult to obtain through live human biopsies. Human postmortem lacrimal gland (LG) and submandibular gland (SMG) tissues have the potential to provide an invaluable source for studying the mechanisms involved in LG and SMG dysfunction. Therefore, we aimed to test the suitability of post-mortem LG and SMG for molecular, biochemical, and cell biological studies. METHODS: LG and SMG tissue from healthy donors was collected and immediately placed in RNA solution and then shipped overnight at 4 °C. After receipt, each gland was divided into three pieces for RNA, protein, and histological analysis, respectively. Total RNA isolated from each LG and SMG was analyzed for RNA integrity using an Agilent Bioanalyzer and reverse transcription-PCR (RT-PCR). For histology, tissues were embedded in paraffin and stained with hematoxylin and eosin. For protein analysis, lysates were prepared and processed for sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting. RESULTS: When the LG and SMG samples were preserved in RNA , the RNA integrity number (RIN) values from the LG and SMG were >7.0 from all three donors, while the RNAs from tissue not preserved in RNA were of poorer quality. The gene and/or protein expression of E-cadherin, aquaporin 5, alpha-smooth muscle actin (α-SMA), ß-actin, and GAPDH was preserved in all samples. In addition, histological analyses showed normal tubuloacinar structures of all glands with serous and mucous producing acini within lobules interspersed with adipose fat. CONCLUSIONS: In this study, we determined that RNA, protein, and histological sections obtained from postmortem human LG and SMG tissue preserved in RNA were of high quality. This would provide a viable source of human LG and SMG tissue suitable for studies of diseases that affect these glands, such as Sjögren's syndrome.
[Mh] MeSH terms primary: Cryopreservation
Eye Proteins/isolation & purification
Lacrimal Apparatus/chemistry
Organ Preservation Solutions
Organ Preservation
RNA/isolation & purification
Submandibular Gland/chemistry
[Mh] MeSH terms secundary: Actins/metabolism
Aged, 80 and over
Aquaporin 5/metabolism
Autopsy
Blotting, Western
Cadherins/metabolism
Electrophoresis, Polyacrylamide Gel
Eye Proteins/metabolism
Female
Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)/metabolism
Humans
Lacrimal Apparatus/metabolism
Middle Aged
RNA/metabolism
Real-Time Polymerase Chain Reaction
Submandibular Gland/metabolism
Tissue Donors
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Name of substance:0 (ACTA2 protein, human); 0 (AQP5 protein, human); 0 (Actins); 0 (Aquaporin 5); 0 (CDH1 protein, human); 0 (Cadherins); 0 (Eye Proteins); 0 (Organ Preservation Solutions); 63231-63-0 (RNA); EC 1.2.1.9 (Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+))
[Em] Entry month:1801
[Cu] Class update date: 180131
[Lr] Last revision date:180131
[Js] Journal subset:IM
[Da] Date of entry for processing:161026
[St] Status:MEDLINE

  3 / 2598 MEDLINE  
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[PMID]: 29356204
[Au] Autor:Yang TL
[Ad] Address:Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
[Ti] Title:Robotic surgery for submandibular gland resection through a trans-hairline approach: The first human series and comparison with applicable approaches.
[So] Source:Head Neck;, 2018 Jan 22.
[Is] ISSN:1097-0347
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Many submandibular gland diseases are treated by surgical intervention. Transcervical surgery results in an obvious cervical scar, whereas the retroauricular approach leaves a scar in the postauricular area. Therefore, robotic submandibular gland resection through a trans-hairline approach is developed to improve postoperative aesthetic outcomes. METHODS: From 2012 to 2017, 24 consecutive patients who met the inclusion criteria and had received submandibular gland resection through the trans-hairline robotic surgery were analyzed. RESULTS: All surgical procedures were successfully performed without conversion and appreciable complications. The incision was completely concealed within the hairs. Treatments of submandibular gland benign or malignant tumors were completed without any positive margins or disease recurrence. CONCLUSION: This study demonstrated the feasibility and safety of the trans-hairline approach for robotic submandibular gland resection in the first human series. The procedure is applicable to many submandibular gland diseases with complete disease control, and has aesthetic advantages over other robotic surgical approaches.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180122
[Lr] Last revision date:180122
[St] Status:Publisher
[do] DOI:10.1002/hed.25058

  4 / 2598 MEDLINE  
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[PMID]: 29297959
[Au] Autor:Woods LT; Camden JM; Khalafalla MG; Petris MJ; Erb L; Ambrus JL; Weisman GA
[Ad] Address:Department of Biochemistry, University of Missouri, Columbia, Missouri, 65211-7310, USA.
[Ti] Title:P2Y R Deletion Ameliorates Sialadenitis in IL-14α-transgenic Mice.
[So] Source:Oral Dis;, 2018 Jan 03.
[Is] ISSN:1601-0825
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Interleukin-14α-transgenic (IL-14αTG) mice develop an autoimmune exocrinopathy with characteristics similar to Sjögren's syndrome, including sialadenitis and hyposalivation. The P2Y receptor (P2Y R) for extracellular ATP and UTP is upregulated during salivary gland inflammation (i.e., sialadenitis) where it regulates numerous inflammatory responses. The present study investigated the role of P2Y Rs in autoimmune sialadenitis in the IL-14αTG mouse model of Sjögren's syndrome. MATERIALS AND METHODS: IL-14αTG mice were bred with P2Y R mice to generate IL-14αTG x P2Y R mice. P2Y R expression, lymphocytic focus scores, B and T cell accumulation and lymphotoxin-α expression were evaluated in the submandibular glands along with carbachol-stimulated saliva secretion in IL-14αTG, IL-14αTG x P2Y R and C57BL/6 control mice at 9 and 12 months of age. RESULTS: Genetic ablation of P2Y Rs in IL-14αTG mice significantly reduced B and T lymphocyte infiltration of submandibular glands. However, reduced sialadenitis did not restore saliva secretion in IL-14αTG x P2Y R mice. Decreased sialadenitis in IL-14αTG x P2Y R mice correlated with decreased lymphotoxin-α levels, a critical proinflammatory cytokine associated with autoimmune pathology in IL-14αTG mice. CONCLUSIONS: The results of this study suggest that P2Y Rs contribute to the development of salivary gland inflammation in IL-14αTG mice and may also contribute to autoimmune sialadenitis in humans. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180103
[Lr] Last revision date:180103
[St] Status:Publisher
[do] DOI:10.1111/odi.12823

  5 / 2598 MEDLINE  
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[PMID]: 29239938
[Au] Autor:Martire MV; Santiago ML; Cazenave T; Gutierrez M
[Ti] Title:Latest Advances in Ultrasound Assessment of Salivary Glands in Sjögren Syndrome.
[So] Source:J Clin Rheumatol;, 2017 Dec 12.
[Is] ISSN:1536-7355
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: There are different imaging techniques to assess the parotid glands (i.e., sialography, salivary gland scintigraphy) in patients with Sjögren syndrome (SS). However, their use is limited by the invasive character or high cost. Ultrasound (US) is gaining interest by rheumatologists as a complementary diagnostic tool for SS. To date, there is an increasing body of evidence supporting its sensitivity in the assessment of salivary glands in SS. The aim of our study was to analyze the potential role of US as a diagnostic and prognostic tool in SS and to discuss existing evidence to support its application use. METHODS: A systematic search was performed in the electronic database PubMed, using the following search terms: (salivary glands OR parotid glands OR submandibular glands) AND Sjögren's syndrome AND (ultrasonography OR ultrasound OR sonography). Titles, abstracts, and full reports were systematically screened. RESULTS: The results of the studies analyzed in this review show encouraging results in terms of accuracy, validity, and diagnostic value, which leads us to believe that in the future US could become the reference imaging tool to assess SS. The studies include a small cohort of patients, and there is no standardized approach in terms of US techniques for the assessment of salivary glands. CONCLUSIONS: Ultrasound of major salivary glands is a useful tool for diagnosis, prognostic evaluation, and response to treatment in SS. The use of this imaging technology is still under development, and more multicentric studies are needed to validate this tool.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171227
[Lr] Last revision date:171227
[St] Status:Publisher
[do] DOI:10.1097/RHU.0000000000000625

  6 / 2598 MEDLINE  
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[PMID]: 29197149
[Au] Autor:Togarrati PP; Dinglasan N; Desai S; Ryan WR; Muench MO
[Ad] Address:Blood Systems Research Institute, San Francisco, CA, U.S.A, 94118.
[Ti] Title:CD29 is highly expressed on epithelial, myoepithelial and mesenchymal stromal cells of human salivary glands.
[So] Source:Oral Dis;, 2017 Dec 02.
[Is] ISSN:1601-0825
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The phenotype of the cells present in the ductal region of salivary glands have been well characterized. However, it is imperative to identify novel biomarkers that can identify different cell types present in other glandular components for the development of therapeutic strategies and diagnostics of salivary gland disorders and malignancies. Our study aimed at the characterization of the expression and distribution of various cell surface markers, especially with a focus on CD29 in human fetal as well as adult glands. MATERIALS AND METHODS: Paired human midgestation fetal and adult parotid, sublingual and submandibular glands were collected. Phenotypic expression of various lineage-specific cell surface markers including CD29 was investigated in freshly collected glands. The findings were further corroborated by immunohistochemistry assay. RESULTS: Enriched expression of CD29 was found on acinar and ductal epithelial, mesenchymal stromal and myoepithelial cells; CD29 cells co-expressed epithelial (CD324, CD326, NKCC1 and CD44), mesenchymal (CD73, CD90, vimentin and CD34) and myoepithelial (α-SMA) cell-specific progenitor markers in both fetal as well as adult salivary glands. CONCLUSION: CD29 is widely expressed in human salivary glands and, it could serve as a potential biomarker for devising novel cellular therapeutic and diagnostic strategies for salivary gland disorders and malignancies. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171220
[Lr] Last revision date:171220
[St] Status:Publisher
[do] DOI:10.1111/odi.12812

  7 / 2598 MEDLINE  
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[PMID]: 29233833
[Au] Autor:Mossel E; Arends S; van Nimwegen JF; Delli K; Stel AJ; Kroese FGM; Spijkervet FKL; Vissink A; Bootsma H; EULAR US-pSS study group
[Ad] Address:Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
[Ti] Title:Scoring hypoechogenic areas in one parotid and one submandibular gland increases feasibility of ultrasound in primary Sjögren's syndrome.
[So] Source:Ann Rheum Dis;, 2017 Dec 12.
[Is] ISSN:1468-2060
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To assess whether ultrasonographic scoring of (i) both parotid and submandibular salivary glands and (ii) all individual components of the Hocevar scoring system, is needed for classifying patients as primary Sjögren's syndrome (pSS). METHODS: Ultrasound examination of the major salivary glands (sUS) was performed in 204 consecutive patients clinically suspected (n=171) or diagnosed (n=33) with pSS.Parenchymal echogenicity, homogeneity, hypoechogenic areas, hyperechogenic reflections and salivary gland posterior border were scored in left and right parotid and submandibular glands. Logistic regression analyses were performed to assess which glands and sUS components contributed significantly to classification as pSS or non-pSS according to the 2016 American College of Rheumatology-European League Against Rheumatism (ACR-EULAR) criteria. RESULTS: 116 (57%) patients were classified as pSS, the remaining as non-pSS. Instead of scoring both sides (area under the curve; AUC=0.856, Nagelkerke R =0.526), multivariate analysis showed that sUS scoring of only right (AUC=0.850; R =0.518) or left (AUC=0.852; R =0.511) parotid and submandibular glands is sufficient to predict ACR-EULAR classification. Moreover, all individual components of the Hocevar scoring system significantly predicted classification. Multivariate analysis showed that parenchymal echogenicity and hypoechogenic areas contributed independently to ACR-EULAR classification (AUC=0.857; R =0.539). Scoring these components in one parotid and one submandibular gland highly predicted ACR-EULAR classification (AUC=0.855; R =0.539). Scoring only hypoechogenic areas on one side showed almost similar results (AUC=0.846; R =0.498). CONCLUSION: sUS examination of parotid and submandibular glands on one side is sufficient to predict classification of patients according to the ACR-EULAR criteria. To further increase feasibility of sUS in outpatient clinics worldwide, only hypoechogenic areas can be scored.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171213
[Lr] Last revision date:171213
[St] Status:Publisher

  8 / 2598 MEDLINE  
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[PMID]: 29019325
[Au] Autor:Chaudhary P; Gupta S; Leekha N; Rajendra RS; Mishra SS; Arora V; De S; Agarwal S
[Ad] Address:Department of Radiation Oncology, Max Super Specialty Hospital, Vaishali, India.
[Ti] Title:Ambiguity of Whole Body PET CT Scans in Diagnosis of Co-existing Tuberculosis and Malignancy: Is Histopathological Confirmation Mandatory?
[So] Source:Gulf J Oncolog;1(25):15-19, 2017 Sep.
[Is] ISSN:2078-2101
[Cp] Country of publication:Kuwait
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Whole body PET CT is an important investigation tool in malignancy patients and helps in ascertaining the metabolic activity and exact stage of the disease. However, like any other investigation, false positive results do exist and certain diseases other than cancer may show increased uptake. Hence, a careful evaluation of PET CT and clinical correlation in malignancy patients is a must to accomplish the suitable treatment. METHODS: In this retrospective observational study, seven cases of cancer with concomitant tuberculosis were included. All the patients were proven malignancy patients with advanced or metastatic stage. On clinical suspicion, a tissue diagnosis was obtained which led to change in staging as well as management of the patients. RESULTS: Seven patients were having primary diagnosis of carcinoma breast, carcinoma esophagus, coepidermoid carcinoma of submandibular salivary gland, carcinoma tongue, squamous cell carcinoma skin, carcinoma cervix and carcinoma endometrium. They showed FDG uptake at distant sites leading to upstaging of disease. On histopathological examination, lymph nodal mass reported granulomatous lymphadenitis, leading to change of overall staging and management of the patients. DISCUSSION AND CONCLUSIONS: Whole Body PET CT scan may produce false positive results and upstage the disease. It should be evaluated and interpreted with caution in cases of doubtful findings and any abnormal FDG accumulation in PET CT scan at unusual locations should be evaluated carefully and confirmed histopathologically.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171011
[Lr] Last revision date:171011
[St] Status:In-Data-Review

  9 / 2598 MEDLINE  
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[PMID]: 28916523
[Au] Autor:Kamekura R; Takano K; Yamamoto M; Kawata K; Shigehara K; Jitsukawa S; Nagaya T; Ito F; Sato A; Ogasawara N; Tsubomatsu C; Takahashi H; Nakase H; Himi T; Ichimiya S
[Ad] Address:Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan; rkameku@sapmed.ac.jp.
[Ti] Title:Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease.
[So] Source:J Immunol;199(8):2624-2629, 2017 Oct 15.
[Is] ISSN:1550-6606
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:IgG4-related disease (IgG4-RD) is a newly recognized systemic chronic fibroinflammatory disease. However, the pathogenesis of IgG4-RD remains unknown. To determine the pathophysiologic features of IgG4-RD, we examined T follicular helper (Tfh) cells in lesions and blood from patients with IgG4-RD. Patients with IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) showed increased infiltration of Tfh cells highly expressing programmed death 1 and ICOS in submandibular glands. Tfh cells from IgG4-DS submandibular glands had higher expression of B cell lymphoma 6 and a greater capacity to help B cells produce IgG4 than did tonsillar Tfh cells. We also found that the percentage of programmed death 1 circulating Tfh cells in IgG4-DS patients was higher than that in healthy volunteers and was well correlated with clinical parameters. Our findings indicate that anomalous Tfh cells in tissue lesions of IgG4-RD have features distinct from those in lymphoid counterparts or blood and potentially regulate local IgG4 production in IgG4-RD.
[Mh] MeSH terms primary: Autoimmune Diseases/immunology
B-Lymphocytes/immunology
Dacryocystitis/immunology
Immunoglobulin G/metabolism
Programmed Cell Death 1 Receptor/metabolism
Submandibular Gland/immunology
T-Lymphocytes, Helper-Inducer/immunology
[Mh] MeSH terms secundary: Adult
Aged
Cell Movement
Cells, Cultured
Female
Humans
Immunoglobulin G/immunology
Inducible T-Cell Co-Stimulator Protein/metabolism
Lymphocyte Activation
Male
Middle Aged
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (ICOS protein, human); 0 (Immunoglobulin G); 0 (Inducible T-Cell Co-Stimulator Protein); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor)
[Em] Entry month:1711
[Cu] Class update date: 171101
[Lr] Last revision date:171101
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170917
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1601507

  10 / 2598 MEDLINE  
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[PMID]: 28895432
[Au] Autor:Goates AJ; Kung RW; Tracy CR; Hoffman HT
[Ad] Address:1 Department of Otolaryngology-Head and Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
[Ti] Title:Intraductal Laser Fiber Tip Fracture and Retrieval During Sialendoscopic Laser-Assisted Lithotripsy.
[So] Source:Ann Otol Rhinol Laryngol;126(11):774-777, 2017 Nov.
[Is] ISSN:1943-572X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Fragmentation of flexible laser fiber tips has been reported to occur during therapeutic bronchoscopy and urologic stone treatment. We report fragmentation of 200-µm single-use silica-based fibers during sialendoscopy-controlled Holmium:YAG laser treatment of a parotid and a submandibular stone. The technique employed to successfully retrieve the fiber tips is described in the context of identifying this potential complication from endoscopic management of sialolithiasis.
[Mh] MeSH terms primary: Endoscopy/instrumentation
Lithotripsy, Laser/instrumentation
Parotid Diseases/therapy
Salivary Gland Calculi/therapy
Submandibular Gland Diseases/therapy
[Mh] MeSH terms secundary: Adult
Aged
Equipment Failure
Humans
Lasers, Solid-State/therapeutic use
Male
Treatment Outcome
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170913
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417728736


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