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[PMID]: 25091689
[Au] Autor:Jehangir S; John J; Rajkumar S; Mani B; Srinivasan R; Kang G
[Ad] Address:Department of Pediatric Surgery, Christian Medical College, Vellore, India....
[Ti] Title:Intussusception in southern India: Comparison of retrospective analysis and active surveillance.
[So] Source:Vaccine;32 Suppl 1:A99-A103, 2014 Aug 11.
[Is] ISSN:1873-2518
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Surveillance for intussusception is a post marketing requirement for rotavirus vaccines following observation of a small increased risk of intussusception after rotavirus vaccination in some global settings. This study presents the clinical presentation and outcomes of children who presented with intussusception at a large tertiary care facility directly (non-surveillance) as retrospective analysis of a period where rotavirus vaccine was not in routine use, or as part of active surveillance in a phase III oral rotavirus vaccine trial. Hospital records of children under 2 years of age treated for intussusception between 1 January 2010 and 31 August 2013 at the Christian Medical College Hospital, Vellore, India, were reviewed. Sixty-one cases of intussusception in children under two years of age presented at the hospital. An additional 16 cases of ultrasound diagnosed intussusception were identified through the active surveillance of a cohort of 1500 children participating in a rotavirus phase III trial in the same period. In the nonsurveillance group, median age at presentation was 214 days (IQR 153-321) with 52 events (85.3%) occurring in the first year of life. Cases were seen year-round with no definitive evidence of seasonality. Thirty-one (50.8%) intussusceptions required surgical reduction, 26 (42.6%) had pneumatic reduction and 2 (3.3%) barium enema reduction. Two intussusceptions (3.3%) resolved spontaneously. There were no deaths, all children were discharged after recovery. Active surveillance identified 16 children with a median age at event of 375 days (IQR 248-574). Nine (56%) children had small bowel or transient intussusception that resolved spontaneously. Seven intussusceptions were reduced radiologically; none required surgery. In summary, there were significant differences between presentation and outcomes in cases of intussusception identified by passive and active surveillance, likely related to enhanced and early detection of intussusception through active monitoring in the trial. The WHO recommendation of sentinel hospital based surveillance for post-marketing surveillance after rotavirus vaccine introduction is likely to a better approach than active surveillance.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 1393063 MEDLINE  
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[PMID]: 24939607
[Au] Autor:Hamada K; Miura Y; Toma N; Miyamoto K; Imanaka-Yoshida K; Matsushima S; Yoshida T; Taki W; Suzuki H
[Ad] Address:Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
[Ti] Title:Gellan sulfate core platinum coil with tenascin-C promotes intra-aneurysmal organization in rats.
[So] Source:Transl Stroke Res;5(5):595-603, 2014 Oct.
[Is] ISSN:1868-601X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The aims of this study were to develop a new coil, gellan sulfate core platinum coil (GSCC), that delivers tenascin-C (TNC) to an aneurysm (GSCC-TNC) and to evaluate the effects on intra-aneurysmal organization. We performed in vitro adsorption tests of TNC to gellan sulfate (GS). GSCC-TNC was produced by immersing GSCC in TNC solution under the following conditions (TNC concentration 10, 50, or 100 µg/mL; TNC immersion time 15, 30, or 60 min) by monitoring intra-aneurysmal organization in a rat blind-ended aneurysm model. In addition, 20 rats randomly underwent implantation of a platinum coil or the GSCC-TNC produced under optimum conditions into an aneurysm, whose organization effects were compared in a blind fashion at 2 weeks post-surgery. GS demonstrated a high affinity to TNC in a dose-dependent fashion (affinity constant = 1.79 × 10(10) (M(-1))). GSCC immersed in 10 µg/mL of TNC solution for 30 and 60 min induced similar and better organization of aneurysmal cavity compared with that for 15 min (the ratio of the organized areas in an aneurysmal cavity-15 min, 27.2 ± 11.8 %; 30 min, 75.6 ± 11.9 %; 60 min, 82.6 ± 19.7 %, respectively) with the preservation of the aneurysmal wall structure, while higher TNC concentrations caused the destruction of the aneurysmal wall. GSCC-TNC produced under 10 µg/mL of TNC solution for 30 min showed a significantly better organization of aneurysms compared with bare platinum coils in rats. A newly developed coil, GSCC-TNC, may be effective for improving intra-aneurysmal organization after coil embolization.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s12975-014-0352-z

  3 / 1393063 MEDLINE  
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[PMID]: 24930128
[Au] Autor:Rutledge WC; Ko NU; Lawton MT; Kim H
[Ad] Address:Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
[Ti] Title:Hemorrhage rates and risk factors in the natural history course of brain arteriovenous malformations.
[So] Source:Transl Stroke Res;5(5):538-42, 2014 Oct.
[Is] ISSN:1868-601X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Brain arteriovenous malformations (AVMs) are abnormal connections of arteries and veins, resulting in arteriovenous shunting of blood. Primary medical therapy is lacking; treatment options include surgery, radiosurgery, and embolization, often in combination. Judicious selection of AVM patients for treatment requires balancing risk of treatment complications against the risk of hemorrhage in the natural history course. This review focuses on the epidemiology, hemorrhage risk, and factors influencing risk of hemorrhage in the untreated natural course associated with sporadic brain AVM.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s12975-014-0351-0

  4 / 1393063 MEDLINE  
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[PMID]: 24965860
[Au] Autor:Lindhagen L; Darkahi B; Sandblom G; Berglund L
[Ad] Address:Uppsala Clinical Research Center, Uppsala, Sweden.
[Ti] Title:Level-adjusted funnel plots based on predicted marginal expectations: an application to prophylactic antibiotics in gallstone surgery.
[So] Source:Stat Med;33(21):3655-75, 2014 Sep 20.
[Is] ISSN:1097-0258
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Funnel plots are widely used to visualize grouped data, for example, in institutional comparison. This paper extends the concept to a multi-level setting, displaying one level at a time, adjusted for the other levels, as well as for covariates at all levels. These level-adjusted funnel plots are based on a Markov chain Monte Carlo fit of a random effects model, translating the estimated model parameters to predicted marginal expectations. Working within the estimation framework, we accommodate outlying institutions using heavy-tailed random effects distributions. We also develop computer-efficient methods to compute predicted probabilities in the case of dichotomous outcome data and various random effect distributions. We apply the method to a data set on prophylactic antibiotics in gallstone surgery. Copyright © 2014 John Wiley & Sons, Ltd.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1002/sim.5677

  5 / 1393063 MEDLINE  
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[PMID]: 25093208
[Au] Autor:Sakai R; Yamamoto T; Uchiyama K; Uchida K; Nakao M; Mabuchi K
[Ad] Address:Department of Medical Engineering and Technology, School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252-0329, Japan....
[Ti] Title:Correlation between the Bone Mineral Density and Stress on Femur around a Duetto SI Stem.
[So] Source:ScientificWorldJournal;2014:786185, 2014.
[Is] ISSN:1537-744X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In cementless stem fixation, BMD reduction around the stem is of concern because it may cause loosening. This BMD reduction is assumed to be caused by stem implantation-induced alteration of the physiological feedback system, which may cause stress shielding and result in loosening, but the causal relationship has not been clarified. In this study, using a Duetto SI stem, we investigated the correlation between the postoperative BMD around the stem and stress. In patients who underwent their first THA at the orthopedic department of our university, the BMD was measured using DEXA, and FEA was performed with an equivalent time course. Time-course changes in the BMD, von Mises stress, and triaxial stress in Gruen zones 1 through 7 were calculated from those measured at 2 weeks and 5 months after surgery. The BMD and von Mises stress showed a bidirectional correlation when Gruen's classification was plotted on the horizontal axis. An increase in stress loaded on bone was assumed to be a factor increasing the BMD. The Duetto SI stem was fixed on the distal side, suggesting its stable fixation. BMD measurement and FEA were useful for quantification of the bone dynamics around the stem from an early phase.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1155/2014/786185

  6 / 1393063 MEDLINE  
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[PMID]: 24408047
[Au] Autor:Niola R; Cavaliere C; Marcello L; Maglione F; de Ritis R; Di Pietto F; Albano G; Nazzaro G; Sirimarco F; Mocerino C; Loreto M; Di Pasquale MA; Nasti G
[Ad] Address:UOSC di Radiologia Vascolare ed Interventistica AORN Cardarelli Napoli, Naples, Italy.
[Ti] Title:Role of interventional radiology in treating obstetric haemorrhages.
[So] Source:Radiol Med;119(8):607-15, 2014 Aug.
[Is] ISSN:1826-6983
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:PURPOSE: The aim of this study was to evaluate the efficacy and the safety of selective uterine artery embolisation in patients with a high risk of haemorrhage due to obstetric issues. MATERIALS AND METHODS: We retrospectively reviewed the angiographic examinations of 63 patients (average age ± SD, 32.6 years ± 4.8), affected by an obstetric disease with a high risk of haemorrhage (22 cases of ectopic pregnancy, 41 of postpartum haemorrhage) and treated with an interventional approach. In particular, we considered the rate of second treatment with interventional technique or conservative or radical surgery, the incidence of postprocedural complications, and the absorbed radiation dose. RESULTS: Immediate technical success, defined as the cessation of active bleeding, was achieved in all cases. Uterine artery embolisation was able alone to control the haemorrhage in 95.24 % of cases. Three patients required a second treatment to achieve haemostasis. No peri- or postprocedural complications were observed. At the 12-month follow-up after embolisation, 22/49 conservatively treated patients were found to be pregnant and successfully completed their pregnancy. CONCLUSIONS: Selective uterine artery embolisation allows for safe and complete control of haemorrhage in patients with obstetric disease, with a very low incidence of complications and preservation of fertility.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1007/s11547-013-0380-x

  7 / 1393063 MEDLINE  
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[PMID]: 25093041
[Au] Autor:Curry JP; Jungquist CR
[Ad] Address:UCLA Department of Anesthesiology, Hoag Memorial Hospital Presbyterian, One Hoag Drive, 92663 Newport Beach, CA, USA.
[Ti] Title:A critical assessment of monitoring practices, patient deterioration, and alarm fatigue on inpatient wards: a review.
[So] Source:Patient Saf Surg;8:29, 2014.
[Is] ISSN:1754-9493
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Approximately forty million surgeries take place annually in the United States, many of them requiring overnight or lengthier post operative stays in the over five thousand hospitals that comprise our acute healthcare system. Leading up to this Century, it was common for most hospitalized patients and their families to believe that being surrounded by well-trained nurses and physicians assured their safety. That bubble burst with the Institute of Medicine's 1999 report: To Err Is Human, followed closely by its 2001 report: Crossing the Quality Chasm. This review article discusses unexpected, potentially lethal respiratory complications known for being difficult to detect early, especially in postoperative patients recovering on hospital general care floors (GCF). We have designed our physiologic explanations and simplified cognitive framework to give our front line clinical nurses a thorough, easy-to-recall understanding of just how these events evolve, and how to detect them early when most amenable to treatment. Our review will also discuss currently available practices in general care floor monitoring that can both improve patient safety and significantly reduce monitor associated alarm fatigue.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1408
[Da] Date of entry for processing:140805
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/1754-9493-8-29

  8 / 1393063 MEDLINE  
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[PMID]: 25093040
[Au] Autor:Stahel PF; Clavien PA
[Ad] Address:Denver Health Medical Center, Denver, USA.
[Ti] Title:Reviewer acknowledgement 2013.
[So] Source:Patient Saf Surg;8:5, 2014.
[Is] ISSN:1754-9493
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTRIBUTING REVIEWERS: The Editors of Patient Safety in Surgery would like to thank all our reviewers who have contributed to the journal in Volume 7 (2013).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Da] Date of entry for processing:140805
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/1754-9493-8-5

  9 / 1393063 MEDLINE  
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[PMID]: 25092454
[Au] Autor:Hu Y; Williams B; Galai I; Nathan N; Smallman B
[Ad] Address:Department of Anesthesiology, SUNY Upstate Medical University, Syracuse, NY, USA. yhut2011@gmail.com.
[Ti] Title:Tongue protrusion as an extubation criterion in pediatric surgery.
[So] Source:Paediatr Anaesth;24(9):1021-2, 2014 Sep.
[Is] ISSN:1460-9592
[Cp] Country of publication:France
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/pan.12491

  10 / 1393063 MEDLINE  
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[PMID]: 24916275
[Au] Autor:Witt L; Glage S; Schulz K; Lichtinghagen R; Simann A; Pape L; Sümpelmann R
[Ad] Address:Clinic of Anaesthesiology, Hanover Medical School, Hanover, Germany.
[Ti] Title:Impact of 6% hydroxyethyl starch 130/0.42 and 4% gelatin on renal function in a pediatric animal model.
[So] Source:Paediatr Anaesth;24(9):974-9, 2014 Sep.
[Is] ISSN:1460-9592
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Artificial colloids, frequently used to prevent hemorrhagic shock in children, may induce serious renal side effects in critically ill adult patients. The impact of perioperative colloid infusion on the renal function in adults and children remains unclear. AIM: To determine the impact of single doses of artificial colloids on renal function tests, we conducted an experimental animal study. We hypothesized that neither the infusion of moderate doses of 6% hydroxyethyl starch (HES) nor of 4% gelatin (GEL) would have a serious impact on the renal function of healthy piglets. METHODS: Fifteen sedated piglets were randomly assigned to receive an infusion of either 20 ml·kg(-1) HES or GEL or a balanced electrolyte solution (BS, control group) over 30 min. Before and 7 days after infusion, serum and urine renal function tests were recorded and renal biopsies were taken. RESULTS: Serum and urine renal function tests (e.g., creatinine, urea, cystatin C, and neutrophil gelatinase-associated lipocalin) were within normal ranges, and a microscopic examination of the renal tissue in all groups revealed no major alterations such as tubular necrosis, interstitial bleeding, interstitial inflammation, or vacuoles. CONCLUSIONS: In this pediatric animal model, the infusion of moderate doses of artificial colloids was not found to have any relevant impact on renal function. Further clinical investigations are necessary to provide a conclusive assessment of the risk for renal impairment after HES and GEL administration during major pediatric surgery.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1408
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/pan.12445


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