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[PMID]: 23905626
[Au] Autor:Naranjo C; Dubielzig RR
[Ad] Address:Departamento de Medicina y Cirugía Animales, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain.
[Ti] Title:Histopathological study of the causes for failure of intrascleral prostheses in dogs and cats.
[So] Source:Vet Ophthalmol;17(5):343-50, 2014 Sep.
[Is] ISSN:1463-5224
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To characterize the histopathological causes for failure of intrascleral prosthesis placement in dogs and cats. PROCEDURES: The Comparative Ocular Pathology Laboratory of Wisconsin database was searched to find canine and feline evisceration samples that were diagnosed with neoplasia. A second population included canine and feline scleral shells that were removed after an evisceration surgery had been performed. The causes for removal were divided into: neoplasia, corneal abnormalities, and other causes. RESULTS: In dogs, 163 of 1985 evisceration samples (8.21%) contained a neoplasm, whereas 17 of 88 (19.31%) evisceration samples in cats contained a neoplasm. In dogs, severe corneal disease was diagnosed in 38 of 80 scleral shells (46.25%) and neoplasia was diagnosed in 31 of 80 scleral shells (38.75%). Malignant melanoma was the most frequently diagnosed tumor, in 14 of 31 scleral shells. In cats, eight of 12 scleral shells contained a tumor (66.7%), with feline diffuse iris melanoma being diagnosed most commonly (six of eight shells). Two of 12 feline scleral shells had severe corneal disease (16.7%). Epithelial downgrowth, lining the inner aspect of the fibrous tunic, was seen in 14 of 38 canine scleral shells and in two of two feline scleral shells with severe corneal disease. CONCLUSIONS: Severe corneal disease and neoplasia are the most common causes for intrascleral prosthesis failure in dogs, whereas neoplasia is the single most common cause for intrascleral prosthesis failure in cats.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/vop.12082

  2 / 1399738 MEDLINE  
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[PMID]: 23803170
[Au] Autor:Turner Giannico A; de Sampaio MO; Lima L; Corona Ponczek C; De Lara F; Montiani-Ferreira F
[Ad] Address:Department of Veterinary Medicine, Federal University of Paraná, Rua dos Funcionários, 1540, Curitiba, PR, 80035-050, Brazil.
[Ti] Title:Characterization of the oculocardiac reflex during compression of the globe in Beagle dogs and rabbits.
[So] Source:Vet Ophthalmol;17(5):321-7, 2014 Sep.
[Is] ISSN:1463-5224
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: This investigation characterizes the occurrence of oculocardiac reflex (OCR) in conscious rabbits and dogs by observing the effect of an ocular compression stimulus on heart rate (HR). ANIMALS STUDIED: Thirty-four clinically healthy adult rabbits and 15 clinically healthy adult Beagle dogs were studied. PROCEDURES: An electrocardiogram was used to record the heart rhythm and HR continuously. Digital pressure was exerted over the eyelid on right eye, left eye and both eyes together for 1 min, with one-minute intervals between each compression. Variations in HR were observed in each minute by counting complexes on the electrocardiographs. RESULTS: There were no differences in HR between stages without ocular compressions both in dogs and in rabbits. HR reduction caused by ocular compression was statistically significant in rabbits only when both eyes were compressed in contrast with all stages without compression. In dogs, a statistically significant reduction in HR was seen during compression of just the right eye or the left eye compared with the baseline HR, and when both the right and left eyes were compressed together compared with baseline or after compression of the right eye. In dogs, compression of individual eyes produced a change similar to that seen during compression of both eyes. CONCLUSIONS: This study shows that OCR can occur during experimental ocular compression in conscious rabbits and Beagle dogs and characterizes the reduction in HR. Knowledge of this physiological response is important for veterinary anesthetists and ophthalmologists during ophthalmic surgery or eye manipulations.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/vop.12077

  3 / 1399738 MEDLINE  
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[PMID]: 25130447
[Au] Autor:Buschschlüter S; Koch C; von Eicken J; Höh H
[Ad] Address:Physikalisch-Technische Bundesanstalt, Braunschweig, Germany. Electronic address: steffen.buschschlueter@ptb.de....
[Ti] Title:Computation of the Temperature Rise at the Corneal Endothelium during Cataract Surgery by Modeling of Heat Generation Inside the Anterior Chamber.
[So] Source:Ultrasound Med Biol;40(10):2431-44, 2014 Oct.
[Is] ISSN:1879-291X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The corneal endothelium sustaining the transparency of the cornea is a vulnerable cell layer. Thermal exposure during phacoemulsification is considered to be a potential cause of post-operative cell loss. Knowledge of the temperature rise and particularly of its dependence on region and system settings could deliver useful information about a potential correlation with cell damage. However, there exists a lack of understanding of the process and location of heat generation. Analytical calculations and experiments enabled the quantification of different mechanisms acting as heat sources during phacoemulsification. Heat generation caused by viscous friction was estimated using both an analytical approach and a numerical simulation. In contrast to absorption of sound and self-heating of the probe, this effect was ascertained to be the main heat source. Calorimetric measurement of the power input verified this modeling. On the basis of these results, the local temperature distribution inside a porcine eye was computed time dependently using the finite-element method. Two different amplitude settings were compared with respect to the temperature increase at the corneal endothelium. Various conclusions on the mitigation of thermal exposure during treatment can be drawn from this finite-element simulation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  4 / 1399738 MEDLINE  
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[PMID]: 25196007
[Au] Autor:Forchelet D; Simoncini M; Arami A; Bertsch A; Meurville E; Aminian K; Ryser P; Renaud P
[Ad] Address:Microsystems Laboratory (LMIS4), École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. david.forchelet@epfl.ch....
[Ti] Title:Enclosed electronic system for force measurements in knee implants.
[So] Source:Sensors (Basel);14(8):15009-21, 2014.
[Is] ISSN:1424-8220
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Total knee arthroplasty is a widely performed surgical technique. Soft tissue force balancing during the operation relies strongly on the experience of the surgeon in equilibrating tension in the collateral ligaments. Little information on the forces in the implanted prosthesis is available during surgery and post-operative treatment. This paper presents the design, fabrication and testing of an instrumented insert performing force measurements in a knee prosthesis. The insert contains a closed structure composed of printed circuit boards and incorporates a microfabricated polyimide thin-film piezoresistive strain sensor for each condylar compartment. The sensor is tested in a mechanical knee simulator that mimics in-vivo conditions. For characterization purposes, static and dynamic load patterns are applied to the instrumented insert. Results show that the sensors are able to measure forces up to 1.5 times body weight with a sensitivity fitting the requirements for the proposed use. Dynamic testing of the insert shows a good tracking of slow and fast changing forces in the knee prosthesis by the sensors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.3390/s140815009

  5 / 1399738 MEDLINE  
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[PMID]: 25010326
[Au] Autor:Matsuo H; Uchida K; Nakajima H; Guerrero AR; Watanabe S; Takeura N; Sugita D; Shimada S; Nakatsuka T; Baba H
[Ad] Address:Division of Physical Therapy and Rehabilitation Medicine, University of Fukui Hospital, Fukui, Japan....
[Ti] Title:Early transcutaneous electrical nerve stimulation reduces hyperalgesia and decreases activation of spinal glial cells in mice with neuropathic pain.
[So] Source:Pain;155(9):1888-901, 2014 Sep.
[Is] ISSN:1872-6623
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Although transcutaneous electrical nerve stimulation (TENS) is widely used for the treatment of neuropathic pain, its effectiveness and mechanism of action in reducing neuropathic pain remain uncertain. We investigated the effects of early TENS (starting from the day after surgery) in mice with neuropathic pain, on hyperalgesia, glial cell activation, pain transmission neuron sensitization, expression of proinflammatory cytokines, and opioid receptors in the spinal dorsal horn. Following nerve injury, TENS and behavioral tests were performed every day. Immunohistochemical, immunoblot, and flow cytometric analysis of the lumbar spinal cord were performed after 8days. Early TENS reduced mechanical and thermal hyperalgesia and decreased the activation of microglia and astrocytes (P<0.05). In contrast, the application of TENS at 1week (TENS-1w) or 2weeks (TENS-2w) after injury was ineffective in reducing hyperalgesia (mechanical and thermal) or activation of microglia and astrocytes. Early TENS decreased p-p38 within microglia (P<0.05), the expression levels of protein kinase C (PKC-γ), and phosphorylated anti-phospho-cyclic AMP response element-binding protein (p-CREB) in the superficial spinal dorsal horn neurons (P<0.05), mitogen-activated protein (MAP) kinases, and proinflammatory cytokines, and increased the expression levels of opioid receptors (P<0.05). The results suggested that the application of early TENS relieved hyperalgesia in our mouse model of neuropathic pain by inhibiting glial activation, MAP kinase activation, PKC-γ, and p-CREB expression, and proinflammatory cytokines expression, as well as maintenance of spinal opioid receptors. The findings indicate that TENS treatment is more effective when applied as early after nerve injury as possible.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  6 / 1399738 MEDLINE  
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[PMID]: 24909733
[Au] Autor:Cook-Sather SD; Li J; Goebel TK; Sussman EM; Rehman MA; Hakonarson H
[Ad] Address:Department of Anesthesiology and Critical Care, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: sather@email.chop.edu...
[Ti] Title:TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
[So] Source:Pain;155(9):1773-83, 2014 Sep.
[Is] ISSN:1872-6623
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Candidate gene studies have revealed limited genetic bases for opioid analgesic response variability. Genome-wide association studies facilitate impartial queries of common genetic variants, allowing identification of novel genetic contributions to drug effect. Illumina (Illumina Inc, San Diego, CA, USA) single nucleotide polymorphism (SNP) arrays were used to investigate SNP associations with total morphine requirement as a quantitative trait locus and with postoperative pain in a retrospective population of opioid-naïve children ages 4-18years who had undergone day surgery tonsillectomy and adenoidectomy. In an independent replication cohort, significant genome-wide association studies-identified SNPs were assayed using TaqMan probes. Among 617 comprehensively phenotyped children, the 277 subjects of European Caucasian (EC) ancestry demonstrated nominal association between morphine dose and a series of novel SNPs (top rs795484, P=1.01×10(-6) and rs1277441, P=2.77×10(-6)) at the TAOK3 locus. Age, body mass index, and physical status were included covariates. Morphine requirement averaged 132.4µg/kg (SD 40.9). Each minor allele at rs795484 (guanine [G]>adenine [A]) contributed +17.6µg/kg (95% confidence interval [CI] 10.7-24.4) to dose. Effect direction and magnitude were replicated in an independent cohort of 75 EC children (P<0.05). No association with morphine dose was detected in African Americans (AA) (n=241). Postoperative pain scores ⩾7/10 were associated with rs795484 (G>A) in the EC cohort (odds ratio 2.35, 95% CI 1.56-3.52, P<0.00005) and this association replicated in AA children (odds ratio 1.76, 95% CI 1.14-2.71, P<0.01). Variants in TAOK3 encoding the serine/threonine-protein kinase, TAO3, are associated with increased morphine requirement in children of EC ancestry and with increased acute postoperative pain in both EC and AA subjects.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review

  7 / 1399738 MEDLINE  
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[PMID]: 24958069
[Au] Autor:Gamble JJ; McKay WP; Wang AF; Yip KA; O'Brien JM; Plewes CE
[Ad] Address:Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Saskatchewan, Saskatoon, SK, Canada.
[Ti] Title:Three-finger tracheal palpation to guide endotracheal tube depth in children.
[So] Source:Paediatr Anaesth;24(10):1050-5, 2014 Oct.
[Is] ISSN:1460-9592
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:BACKGROUND: Accurate endotracheal tube (ETT) depth is critical, especially in children. The current tools used to guide appropriate ETT depth have significant limitations. OBJECTIVES: To evaluate the utility of tracheal palpation in the neck to guide appropriate ETT placement in children. METHODS: A prospective observational study with a convenience sample of 50 children was conducted. During intubation, an investigator palpated the trachea with three fingertips side-by-side extending upward from the suprasternal notch. The anesthesiologist advanced the ETT slowly until palpated at the sternal notch. The investigator stated ETT palpation certainty as 'strongly felt', 'weakly felt', or 'not felt.' Final ETT position was determined by bronchoscopy and categorized as 'ETT too shallow' (tip in proximal » of trachea), 'ETT too deep' (tip in distal » of trachea), or 'ETT placement satisfactory' (between those extremes). RESULTS: Thirty boys and 20 girls undergoing dental surgery with nasal intubation were recruited (median age 4.4 years; range 2.0-10.8). The ETT (all ≥4 mm ID) was palpable at the sternal notch in all patients: 46 of 50 strongly palpable and 4 of 50 weakly palpable. The experimental methods led to satisfactory ETT placement in 49 of 50 patients, too deep in 1 of 50 patients. Compared with the Pediatrics Advanced Life Support (PALS) predictive formula, satisfactory placement would have been 41 of 50 patients (P < 0.008). Number needed to treat is 6.3 for improvement over the PALS method. CONCLUSIONS: The use of tracheal palpation to guide ETT placement has excellent clinical performance and better guides appropriate ETT depth than the PALS formula in our study population.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/pan.12452

  8 / 1399738 MEDLINE  
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[PMID]: 24824287
[Au] Autor:Lee JJ; Sun LS; Gu B; Kim M; Wang S; Han S
[Ad] Address:Department of Anesthesiology, Harvard Medical School, Boston, MA, USA.
[Ti] Title:Does obesity prolong anesthesia in children undergoing common ENT surgery?
[So] Source:Paediatr Anaesth;24(10):1037-43, 2014 Oct.
[Is] ISSN:1460-9592
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To report the epidemiology of obesity in a pediatric surgical population and determine whether obesity is a risk factor for longer anesthesia duration. BACKGROUND: Childhood obesity is a significant public health problem in the United States. Epidemiologic studies on pediatric surgical populations have been limited to states with very high prevalence of adult obesity (Michigan, Texas). Data from other states and more recent data since 2006 are unavailable. METHODS: We examined anesthesia records for surgical patients age 2-18 years at Columbia University Medical Center from January 2009 to December 2010. Patients undergoing bariatric surgery or those with records missing preoperative height or weight data were excluded. Body mass index (BMI) was calculated as weight (kg)/height (m(2) ). BMI ≥95th percentile according to national growth charts were considered obese. RESULTS: We reviewed 9522 patients of which 1639 were obese (17.2%). The sex-age category interaction on obesity was not significant using logistic regression (P = 0.11). Among surgical groups, the otolaryngology (ENT) cohort had the highest obesity rate (21.7%, 360/1656). Obese children who had tonsillectomy, adenoidectomy, or both did not have a prolonged anesthetic (P = 0.33) or surgical duration (P = 0.61) compared with nonobese children, adjusting for surgeon, season, surgical procedure code, and ASA status. CONCLUSION: Children presenting for surgery, particularly the ENT cohort, have a high prevalence of obesity. Obese and nonobese children who had tonsillectomy, adenoidectomy, or both had comparable durations of anesthesia. Therefore, obesity did not lead to longer anesthetic duration.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/pan.12442

  9 / 1399738 MEDLINE  
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[PMID]: 24802626
[Au] Autor:Gifford J; Larimer K; Thomas C; May P; Stanhope S; Gami A
[Ad] Address:Edward Hospital, Naperville, Illinois.
[Ti] Title:Randomized Controlled Trial of Perioperative ICD Management: Magnet Application versus Reprogramming.
[So] Source:Pacing Clin Electrophysiol;37(9):1219-24, 2014 Sep.
[Is] ISSN:1540-8159
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: There are insufficient data to guide perioperative implantable cardioverter-defibrillator (ICD) management for patients undergoing surgical procedures using electrocautery. METHODS: We conducted a multicenter randomized controlled trial of patients with ICDs undergoing surgery with monopolar electrocautery. Subjects were randomized to an "Off" group (ICD therapy programmed off, then postoperatively programmed on) or a "Magnet" group (ICD therapy suspended with a magnet and no immediate postoperative ICD interrogation). Also, a registry was maintained of ICD patients with procedures within 6 inches of the ICD (all programmed off). The primary endpoint was ICD off time with secondary endpoints being caregiver handoffs and incidence of electromagnetic interference (EMI). RESULTS: All patients (n = 80) had pectoral ICDs. Subject demographics were well matched in each group, and duration of electrocautery was similar (80 minutes vs 64 minutes, P = 0.58). The mean "excess" ICD off time (ICD off time - electrocautery time) was significantly higher in the Off group than the Magnet group (115 minutes vs 28 minutes, P < 0.001). Mean number of caregiver handoffs were higher in the Off group (6.6 vs 5.5, P < 0.001). There was no EMI in any lower abdominal or lower extremity procedures. Neither group had arrhythmic events or device reset. CONCLUSION: A magnet protocol simplifies perioperative ICD management for procedures using electrocautery more than 6 inches from the ICD. This protocol results in significantly shorter time with ICD therapy off, fewer provider handoffs, no risk of inadvertently discharging patients home with ICD therapies off, and no device reset.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/pace.12417

  10 / 1399738 MEDLINE  
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[PMID]: 25194868
[Au] Autor:Mátrai Z; Rényi Vámos F
[Ad] Address:Országos Onkológiai Intézet, Daganatsebészeti Központ Emlo- és Lágyrészsebészeti Osztály Budapest Ráth Gy. u. 7-9. 1125.
[Ti] Title:A távoli áttétképzo és lokálisan kiújult emlorákok sebészi kezelésének lehetoségei. [Surgical possibilities in the treatment of advanced and locally recurrent breast cancers].
[So] Source:Orv Hetil;155(37):1461-8, 2014 Sep 1.
[Is] ISSN:0030-6002
[Cp] Country of publication:Hungary
[La] Language:hun
[Ab] Abstract:Stage IV breast cancer is an incurable but treatable condition. Therapy of distant metastatic disease consists primarily of systemic and symptomatic treatments, while the role of surgery is subordinate. Conventional medical treatments result in 18-24 months average overall survival, and about 5-20% 5-year overall survival. However, it seems that in selected cases with solitary or oligometastases, mainly in those which respond well to drug therapy, the aggressive surgical removal of both the primary tumour and visceral metastases results in a survival advantage. After accurate evaluation of the patients, the indication for surgical treatment should be established through a biological and multidisciplinary approach. Other possible indications for surgical treatment are ulceration, bleeding, hygienic conditions undignified of human life, central nervous system metastases, acute neurological disorders, hydro- and pneumothorax greatly reducing respiratory surface and impending fractures. Surgical procedures include simple pleural drainage, minimal invasive techniques, large body cavity surgeries, extensive resection of soft tissue and chest wall due to the primary tumor, and plastic surgical reconstruction as well. Scientific assessment of the oncological value of surgical oncological interventions in stage IV. breast cancer require further multicentric prospective comparative studies. The present paper provides a broad review of the literature on surgical interventions and results in patients with breast cancer and remote metastases, and the surgical options of locally recurrent tumours. Orv. Hetil., 2014, 155(37), 1461-1468.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1409
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1556/OH.2014.29891


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