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[PMID]: 29464998
[Au] Autor:Finley BL; Benson SM; Marsh GM
[Ad] Address:a Cardno ChemRisk , Brooklyn , NY , USA.
[Ti] Title:Response to letters regarding "Cosmetic talc as a risk factor for pleural mesothelioma: a weight of evidence evaluation of the epidemiology".
[So] Source:Inhal Toxicol;30(1):1-4, 2018 Jan.
[Is] ISSN:1091-7691
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review
[do] DOI:10.1080/08958378.2018.1438540

  2 / 2751 MEDLINE  
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[PMID]: 29466418
[Au] Autor:Dhar Purkayastha G; Mangar P; Saha A; Saha D
[Ad] Address:Department of Biotechnology, University of North Bengal, Siliguri, West Bengal, India.
[Ti] Title:Evaluation of the biocontrol efficacy of a Serratia marcescens strain indigenous to tea rhizosphere for the management of root rot disease in tea.
[So] Source:PLoS One;13(2):e0191761, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The aim of the present study is to evaluate plant growth promoting and biocontrol efficacy of a Serratia marcescens strain ETR17 isolated from tea rhizosphere for the effective management of root rot disease in tea. Isolated bacterial culture ETR17 showed significant level of in vitro antagonism against nine different foliar and root pathogens of tea. The phenotypic and molecular characterization of ETR17 revealed the identity of the bacterium as Serratia marcescens. The bacterium was found to produce several hydrolytic enzymes like chitinase, protease, lipase, cellulase and plant growth promoting metabolites like IAA and siderophore. Scanning electron microscopic studies on the interaction zone between pathogen and antagonistic bacterial isolate revealed severe deformities in the fungal mycelia. Spectral analyses (LC-ESI-MS, UV-VIS spectrophotometry and HPLC) and TLC indicated the presence of the antibiotics pyrrolnitrin and prodigiosin in the extracellular bacterial culture extracts. Biofilm formation by ETR17 on polystyrene surface was also observed. In vivo application of talc-based formulations prepared with the isolate ETR17 in tea plantlets under green house conditions revealed effective reduction of root-rot disease as well as plant growth promotion to a considerable extent. Viability studies with the ETR17 talc formulation showed the survivability of the isolate up to six months at room temperature. The sustenance of ETR17 (concentration of 8-9x108 cfu g-1) in the soil after the application of talc formulation was recorded by ELISA. Safety studies revealed that ETR17 did not produce hemolysin as observed in pathogenic Serratia strains. The biocontrol strain reported in this study can be used for field application in order to minimize the use of chemical fungicides for disease control in tea gardens.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1802
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:In-Process
[do] DOI:10.1371/journal.pone.0191761

  3 / 2751 MEDLINE  
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[PMID]: 29331896
[Au] Autor:Kazakis N; Kantiranis N; Kalaitzidou K; Kaprara E; Mitrakas M; Frei R; Vargemezis G; Vogiatzis D; Zouboulis A; Filippidis A
[Ad] Address:Aristotle University of Thessaloniki, School of Geology, Lab. of Engineering Geology and Hydrogeology, 54124, Thessaloniki, Greece.
[Ti] Title:Environmentally available hexavalent chromium in soils and sediments impacted by dispersed fly ash in Sarigkiol basin (Northern Greece).
[So] Source:Environ Pollut;235:632-641, 2018 Apr.
[Is] ISSN:1873-6424
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Hexavalent chromium is one of the most toxic and carcinogenic species known and can be released into the environment from several sources. In Sarigkiol basin (N Greece) the presence of Cr(VI) in soil, sediments and groundwater may originate from both natural (ophiolitic rocks and their weathering products) and anthropogenic (dispersed fly ash produced from lignite power plants) sources. In this study, the distribution of contents and origin of environmentally available Cr(VI) in soils, sediments, regoliths and fly ash of Sarigkiol basin is presented. Detailed geochemical and mineralogical studies were performed on soil samples (up to 1 m) and regoliths, while leaching tests were also applied to fresh and old fly ash samples. Leachable chromium from soil and sediment samples generally increased with depth and the highest concentrations were observed near to the power plant of Agios Dimitrios. The speciation of chromium in leachates revealed that Cr(VI) concentrations accounted for more than 96% of total Cr. Leaching tests of regoliths established that the natural contribution of Cr(VI) is up to 14 µg kg . Therefore, the measurement of higher concentrations (up to 80 µg kg ) of environmentally available Cr(VI) in soils and sediments can be attributed to the impact/presence of dispersed fly ash in the soils and sediments of the same area. This was also supported by the low correlation recorded between environmentally available chromium and Cr-bearing minerals (mainly serpentine and talc). The influenced zone is located in the eastern part of the basin near the local power plant and surrounds an open conveyor belt that transfers fly ash to an open temporary storage pit. This zone overlies an unconfined porous aquifer thus explaining the elevated concentrations of Cr(VI) in groundwater (up to 120 µg L ) previously reported in this area.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Process

  4 / 2751 MEDLINE  
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[PMID]: 29478341
[Au] Autor:Mercer RM; Hassan M; Rahman NM
[Ad] Address:a Oxford Respiratory Trials Unit , University of Oxford , Oxford , UK.
[Ti] Title:The role of pleurodesis in respiratory diseases.
[So] Source:Expert Rev Respir Med;:1-12, 2018 Feb 28.
[Is] ISSN:1747-6356
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Pleurodesis is used to obliterate the pleural space, most commonly in patients with symptomatic malignant pleural effusions but also in patients with benign effusions or pneumothorax. Areas covered: Traditionally, chemical pleurodesis has been undertaken at thoracoscopy or using instillation of a slurry through a chest drain. The optimum method of achieving pleurodesis, whether surgical or medical, has yet to be proven. Evidence in the different disease areas will be reviewed, along with ongoing trial evidence, which may change practice. Expert commentary: Newer methods of achieving pleurodesis are being introduced. Studies have shown that instilling sclerosing agents via an indwelling pleural catheter or introducing drug-eluting catheters are safe and effective ways of inducing pleurodesis. There is evidence that pleurodesis might increase in survival, especially after pleural infection, possibly due to activation of the immune system. Multiple studies are currently underway to answer some of these questions and the future landscape may be very different from the present.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher
[do] DOI:10.1080/17476348.2018.1445971

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[PMID]: 29334386
[Au] Autor:Brendlé J
[Ad] Address:Axe Transferts, Réactivité, Matériaux pour des Procédés Propres, Institut de Science des Matériaux de Mulhouse UMR CNRS 7361, Université de Haute Alsace, Université de Strasbourg, 3b rue A. Werner, 68093 Mulhouse Cedex, France. jocelyne.brendle@uha.fr.
[Ti] Title:Organic-inorganic hybrids having a talc-like structure as suitable hosts to guest a wide range of species.
[So] Source:Dalton Trans;47(9):2925-2932, 2018 Feb 27.
[Is] ISSN:1477-9234
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The sol-gel process involving hydrolysis and condensation reactions is an attractive way to form siloxane based hybrid materials since it is a one-step method performed under mild conditions. Organic-inorganic hybrids having a talc-like structure (TLH) can be obtained using this procedure starting from organotrialkoxysilanes having the formula R-Si(OR') (where R stands for an organic moiety and R' for a methyl or ethyl group) with different functionalities, an aqueous or ethanolic solution of a magnesium salt, and in some cases, an aqueous solution of sodium hydroxide. In this way, the organic chains are covalently bonded to the silicon of the tetrahedral sheets, pointing toward the interlayer space. The interesting feature in this case is that as many organotrialkoxysilanes are on the market, a wide range of organic moieties can be introduced in the interlayer space leading to applications in various fields. This review highlights the latest trends and the multifaceted applications of these functional layered compounds.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:In-Process
[do] DOI:10.1039/c7dt03902f

  6 / 2751 MEDLINE  
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[PMID]: 29251469
[Au] Autor:Kaur R; Joshi N; Virk JS; Sharma S
[Ti] Title:Evaluation of Pseudomonas fluorescens for the management of tomato early blight disease and fruit borer.
[So] Source:J Environ Biol;37(5):869-872, 2016 09.
[Is] ISSN:0254-8704
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Early blight disease and fruit damage by Helicoverpa armigera are serious problems of tomato causing heavy losses in the yield. An experiment was conducted to evaluate the efficacy of talc based formulation of antagonist Pseudomonas flourescens (Psf) delivered through two different forms of substrate, farmyard manure (FYM) and vermicompost, for the management of tomato early blight disease. Two treatments of Psf, were selected Solarization of nursery soil + seeds and seedlings root dip treatment with Psf formulation + Use of FYM colonized with Psf formulation; Solarization of nursery soil + seed and seedlings root dip treatment with Psf formulation + Use of vermicompost colonized with Psf formulation. These were compared with farmer's practice and untreated control. The impact of all these treatments on tomato fruit borer, H. armigera was also studied. There was not much variation in plant growth parameters (plant height and canopy width) between all the treatments. Both biocontrol treatments (17.69% and 141.3 q acre-1; 15.70% and 139.4 q acre-1, respectively), as well as farmer's practice (10.25% and 208.5 q acre-1) were found to be better than untreated control (29.21% and 94.6 q acre-1) in reducing the incidence of early blight disease in tomato and increasing the marketable yield of tomato fruits. However, the farmer's practice was found to be significantly better than both biocontrol treatments of Psf in controlling fruit damage due to disease, as well as fruit borer. The effect of both bioagents enriched formulations i.e. FYM+Psf and vermicompost+Psf with respect to disease was significantly at par with each other, whereas they had no impact on the fruit borer incidence. The results indicated that either of biocontrol treatments of P. flourescens using farmyard manure and vermicompost, as delivery substrates, can be considered as one of the component along with chemical control in developing IPM programme for the management of early blight disease in tomato.
[Mh] MeSH terms primary: Antibiosis
Lycopersicon esculentum/microbiology
Moths/microbiology
Pest Control, Biological
Plant Diseases/microbiology
Pseudomonas fluorescens/physiology
[Mh] MeSH terms secundary: Animals
Composting
Manure
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Manure)
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[Js] Journal subset:IM
[Da] Date of entry for processing:171219
[St] Status:MEDLINE

  7 / 2751 MEDLINE  
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[PMID]: 29458205
[Au] Autor:Deshpande TM; Quadir A; Obara S; Ibrahim A; Hoag SW
[Ad] Address:Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, United States.
[Ti] Title:Developing a Stable Aqueous Enteric Coating Formulation with Hydroxypropyl methylcellulose acetate succinate (HPMCAS-MF) and Colloidal Silicon Dioxide as Anti-tacking Agent.
[So] Source:Int J Pharm;, 2018 Feb 16.
[Is] ISSN:1873-3476
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The purpose of this study was to use statistical design of experiments to develop a stable aqueous enteric coating formulation containing stabilizing excipients, such as polyethylene glycol that can minimize hydroxypropyl methylcellulose acetate succinate aggregation and minimize spray-nozzle clogging at elevated processing temperatures. The mechanisms of stabilization (i.e. charge stabilization and molecular interactions) were studied by performing zeta potential and FTIR studies. Electrostatic stabilization by sodium lauryl sulfate and hydrogen bonding by polyethylene glycol provided dispersion stability and yielded a stable aqueous coating formulation that prevented spray-nozzle clogging. An enteric coated tablet with better gastric resistance was obtained by incorporating fumed silica (Aerosil R972) as the anti-tacking agent instead of talc. Dissolution testing on the riboflavin enteric coated tablets showed a good enteric release profile without releasing riboflavin in 0.1 N HCl, and completely disintegrating within 10 min in phosphate buffer (pH 6.8).
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180219
[Lr] Last revision date:180219
[St] Status:Publisher

  8 / 2751 MEDLINE  
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[PMID]: 29353472
[Au] Autor:Mering JA; Barker SLL
[Ad] Address:School of Science, University of Waikato , Hamilton, 3240, New Zealand.
[Ti] Title:Precise Measurement of the Hydrogen Isotope Composition of Phyllosilicates by Continuous Flow Off-Axis Integrated Cavity Output Spectroscopy.
[So] Source:Anal Chem;90(4):2852-2859, 2018 Feb 20.
[Is] ISSN:1520-6882
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:New methodology is presented for analyzing hydrogen isotope ratios (D/H) in phyllosilicate minerals by laser absorption spectroscopy. D/H measurements were carried out using an off-axis integrated cavity output spectroscopy (OA-ICOS) instrument operated in a continuous flow configuration. Water was extracted from minerals in a high temperature quartz column and advanced to the analyzer in a dry air carrier gas stream. We report the first D/H measurements by a laser system for serpentine, muscovite, sericite, talc, and biotite. We also measure kaolinite, gypsum, and small volumes of water. Materials, excluding biotite, were calibrated to within 1.5‰ of IRMS-measured δD values, with an average precision of 1.1‰. Biotite δD measurements were up to 10‰ more positive than established IRMS values, due to partial reduction of evolved waters by Fe in the high temperature column. We provide recommendations for overcoming redox interference for measurements of biotite, and other ferrous materials, by OA-ICOS. Rapid, precise, and accurate analyses were carried out on water volumes as low as 0.25 µL extracted from minerals. With the exception of talc, the time required for thermal dewatering and measurement is 140 s, which translates into a throughput of up to 6 mineral samples per hour, including replicates. By demonstrating high precision, rapid throughput, low cost, and ease of operation, we provide a tool that should enable researchers at institutions with limited funding to routinely measure D/H in hydrous minerals. The protocols presented herein should also be useful to commercial users seeking to produce high density isotope data sets relevant to exploration of hydrothermal ore deposits and geothermal fields.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:In-Data-Review
[do] DOI:10.1021/acs.analchem.7b04992

  9 / 2751 MEDLINE  
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[PMID]: 29441468
[Au] Autor:Albertini B; Melegari C; Bertoni S; Dolci LS; Passerini N
[Ad] Address:Department of Pharmacy and BioTechnology, University of Bologna, Via S. Donato 19/2, 40127, Bologna, Italy. beatrice.albertini@unibo.it.
[Ti] Title:A Novel Approach for Dry Powder Coating of Pellets with Ethylcellulose. Part II: Evaluation of Caffeine Release.
[So] Source:AAPS PharmSciTech;, 2018 Feb 13.
[Is] ISSN:1530-9932
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The objective of this study was to assess the efficacy and the capability of a novel ethylcellulose-based dry-coating system to obtain prolonged and stable release profiles of caffeine-loaded pellets. Lauric and oleic acids at a suitable proportion were used to plasticize ethylcellulose. The effect of coating level, percentage of drug loading, inert core particle size, and composition of the coating formulation including the anti-sticking agent on the drug release profile were fully investigated. A coating level of 15% w/w was the maximum layered amount which could modify the drug release. The best controlled drug release was obtained by atomizing talc (2.5% w/w) together with the solid plasticizer during the dry powder-coating process. SEM pictures revealed a substantial drug re-crystallization on the pellet surface, and the release studies evidenced that caffeine diffused through the plasticized polymer acting as pore former. Therefore, the phenomenon of caffeine migration across the coating layer had a strong influence on the permeability of the coating membrane. Comparing dry powder-coated pellets to aqueous film-coated ones, drug migration happened during storage, though more sustained release profiles were obtained. The developed dry powder-coating process enabled the production of stable caffeine sustained release pellets. Surprisingly, the release properties of the dry-coated pellets were mainly influenced by the way of addition of talc into the dry powder-coating blend and by the drug nature and affinity to the coating components. It would be interesting to study the efficacy of novel coating system using a different API.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:Publisher
[do] DOI:10.1208/s12249-018-0964-9

  10 / 2751 MEDLINE  
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[PMID]: 29359509
[Au] Autor:Arellano-Orden E; Romero-Romero B; Sánchez-López V; Martín-Juan J; Rodríguez-Panadero F; Otero-Candelera R
[Ad] Address:Instituto de Biomedicina de Sevilla (IBiS), Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Seville, Spain.
[Ti] Title:Survivin is a negative prognostic factor in malignant pleural effusion.
[So] Source:Eur J Clin Invest;, 2018 Jan 23.
[Is] ISSN:1365-2362
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Survivin is a well-known member of the inhibitor of apoptosis family, and has been related to increased tumour aggressivity, both in tissue and in pleural fluid. OBJECTIVES: In patients with malignant pleural effusion, we sought to investigate the changes in pleural fluid survivin concentrations induced by talc instillation into the pleural space. Those changes were also examined in relation to pleurodesis outcome and patient survival. METHODS: We investigated 84 patients with malignant pleural effusion who underwent talc pleurodesis. Of them, 32 had breast cancer, 25 lung cancer and 27 had mesothelioma. Serial samples of pleural fluid were obtained before thoracoscopy (baseline) and 24 hours thereafter. RESULTS: Survivin levels were successfully quantified in all pleural fluid samples, and they were significantly higher in samples obtained after thoracoscopic talc poudrage compared with baseline (P < .001). Patients with higher pleural fluid survivin levels at baseline had a significantly poorer pleurodesis outcome (P = .004). A 30 pg/mL cut-off for baseline survivin in pleural fluid predicted failure of pleurodesis with a 54% sensitivity and 79% specificity (P = .009). Moreover, median postpleurodesis survival of patients with baseline survivin levels ≥30 pg/mL was 4 months (range: 0.1-38), compared with 13 months (range: 0.1-259) in patients below that cut-off (P < .001). CONCLUSION: Elevated pleural fluid survivin concentrations are useful to predict failure of pleurodesis and are associated with shorter survival in patients with malignant pleural effusion.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:Publisher
[do] DOI:10.1111/eci.12895


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