Database : MEDLINE
Search on : technetium and tc and 99m and exametazime [Words]
References found : 2924 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 293 go to page                         

  1 / 2924 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 28050751
[Au] Autor:Lauridsen TK; Iversen KK; Ihlemann N; Hasbak P; Loft A; Berthelsen AK; Dahl A; Dejanovic D; Albrecht-Beste E; Mortensen J; Kjær A; Bundgaard H; Bruun NE
[Ad] Address:Department of Cardiology, The Heart Center, Copenhagen University Hospital, Copenhagen, Denmark. trineklauridsen@gmail.com.
[Ti] Title:Clinical utility of F-FDG positron emission tomography/computed tomography scan vs. Tc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis.
[So] Source:Int J Cardiovasc Imaging;33(5):751-760, 2017 May.
[Is] ISSN:1875-8312
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The extra-cardiac work-up in infective endocarditis (IE) comprises a search for primary and secondary infective foci. Whether FDG-PET/CT or WBC-SPECT/CT is superior in detection of clinically relevant extra-cardiac manifestations in IE is unexplored. The objectives of this study were to identify the numbers of positive findings detected by each imaging modality, to evaluate the clinical relevance of these findings and to define the reproducibility for extra-cardiac foci in patients with definite IE. Each modality was evaluated for numbers and location of positive extra-cardiac foci in patients with definite IE. A team of 2 × 2 cardiologists evaluated each finding to determine clinical relevance. Clinical utility was determined by 4 criteria converted into an ordinal scale. Using the manifestation with highest clinical utility rating in each patient, the clinical impact of the two imaging modalities was expressed in a clinical utility score. To evaluate reproducibility for each modality, an imaging core laboratory reviewed all findings. In 55 IE patients, 91 pathological foci were found by FDG-PET/CT and 37 foci were identified by WBC-SPECT/CT (p < 0.001). The clinical utility of FDG-PET/CT was significantly higher than that of WBC-SPECT/CT when comparing clinical utility score (2.06 vs. 1.17; p = 0.01). In assessment of extra-cardiac diagnostics in IE, inter-observer reproducibility was substantial for WBC-SPECT/CT (k 0.69, 95% CI 0.49-0.89) and substantial to excellent for FDG-PET/CT (k 0.79, 95% CI 0.61-0.98). FDG-PET/CT has a significantly higher clinical utility score than WBC SPECT/CT and is potentially superior to WBC-SPECT/CT in detection of extra-cardiac pathology in patients with IE.
[Mh] MeSH terms primary: Endocarditis/diagnostic imaging
Fluorodeoxyglucose F18/administration & dosage
Leukocytes
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals/administration & dosage
Single Photon Emission Computed Tomography Computed Tomography
Technetium Tc 99m Exametazime/administration & dosage
[Mh] MeSH terms secundary: Aged
Endocarditis/blood
Female
Humans
Male
Middle Aged
Observer Variation
Predictive Value of Tests
Reproducibility of Results
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Entry month:1710
[Cu] Class update date: 171018
[Lr] Last revision date:171018
[Js] Journal subset:IM
[Da] Date of entry for processing:170105
[St] Status:MEDLINE
[do] DOI:10.1007/s10554-016-1047-1

  2 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 27853826
[Au] Autor:Coelho PB; Fernandes A; Oliveira A; Faria T; Pereira J
[Ad] Address:Universidade Fernando Pessoa Faculdade de Ciencias da Saude, Porto, Portugal. pbarata@ufp.edu.pt.
[Ti] Title:Brain perfusion SPECT for brain death assessment.
[So] Source:Eur J Nucl Med Mol Imaging;44(2):350-351, 2017 Feb.
[Is] ISSN:1619-7089
[Cp] Country of publication:Germany
[La] Language:eng
[Mh] MeSH terms primary: Brain Death/diagnostic imaging
Brain/diagnostic imaging
Cerebral Angiography/methods
Perfusion Imaging/methods
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon/methods
[Mh] MeSH terms secundary: Fatal Outcome
Humans
Male
Middle Aged
Radiopharmaceuticals
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Entry month:1703
[Cu] Class update date: 170926
[Lr] Last revision date:170926
[Js] Journal subset:IM
[Da] Date of entry for processing:161118
[St] Status:MEDLINE
[do] DOI:10.1007/s00259-016-3565-4

  3 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 27900758
[Au] Autor:Derlin T; Weiberg D
[Ad] Address:Hannover Medical School. Derlin.Thorsten@mh-hannover.de.
[Ti] Title:99mTc-HMPAO perfusion SPECT/CT in the diagnosis of brain death.
[So] Source:Nucl Med Rev Cent East Eur;19(B):22-23, 2016.
[Is] ISSN:1644-4345
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:This report describes a case of brain death (BD) evaluated by 99mTc-hexamethylpropylene amine oxime (HMPAO) single photon emission tomography/computed tomography (SPECT/CT). A 16-year-old boy with a history of rapid unexpected brain herniation due to pilocytic astrocytoma underwent 99mTc-HMPAO SPECT/CT for evaluation of brain death in the context of organ donation. Flow images demonstrated lack of blood flow to the brain, and delayed images showed absence of demonstrable radionuclide activity within the brain. SPECT/CT confirmed absence of tracer accumulation, and was deemed helpful for evaluation of the brain stem. 99mTc-HMPAO SPECT/CT is a valuable tool enabling imaging-based confirmation of BD.
[Mh] MeSH terms primary: Brain Death/diagnostic imaging
[Mh] MeSH terms secundary: Adolescent
Brain/blood supply
Brain/diagnostic imaging
Brain Stem/blood supply
Brain Stem/diagnostic imaging
Cerebrovascular Circulation
Functional Neuroimaging
Humans
Male
Radiopharmaceuticals
Single Photon Emission Computed Tomography Computed Tomography
Technetium Tc 99m Exametazime
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Entry month:1703
[Cu] Class update date: 170315
[Lr] Last revision date:170315
[Js] Journal subset:IM
[Da] Date of entry for processing:161201
[St] Status:MEDLINE
[do] DOI:10.5603/NMR.2016.0033

  4 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27764040
[Au] Autor:Matesan MC; Elojeimy S; Minoshima S
[Ad] Address:From the *Department of Radiology, University of Washington, Seattle, WA; †Department of Radiology, University of New Mexico, Albuquerque, NM; and ‡Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT.
[Ti] Title:123I-FP-CIT and 99mTc-HMPAO in Pathologically Confirmed Progressive Supranuclear Palsy.
[So] Source:Clin Nucl Med;41(12):e514-e516, 2016 Dec.
[Is] ISSN:1536-0229
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Molecular brain imaging I-FP-CIT SPECT is an important tool in evaluation of patients with parkinsonism. However, various neurodegenerative etiologies cannot be differentiated by I-FP-CIT SPECT alone. We present a case of progressive supranuclear palsy with abnormal I-FP-CIT SPECT and abnormal Tc-HMPAO SPECT depicted by quantitative analyses but unremarkable MRI 16 months after the onset of symptoms. Brain autopsy demonstrated presence of neuronal and glial tau pathology in both cortical and subcortical regions confirming the diagnosis of progressive supranuclear palsy. This case illustrates potential values of multimodal molecular brain imaging in conjunction with quantitative analysis in the evaluation of movement disorders.
[Mh] MeSH terms primary: Radiopharmaceuticals
Supranuclear Palsy, Progressive/diagnostic imaging
Technetium Tc 99m Exametazime
Tropanes
[Mh] MeSH terms secundary: Female
Humans
Middle Aged
Tomography, Emission-Computed, Single-Photon
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 0 (Tropanes); 155797-99-2 (2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Entry month:1612
[Cu] Class update date: 161230
[Lr] Last revision date:161230
[Js] Journal subset:IM
[Da] Date of entry for processing:161108
[St] Status:MEDLINE

  5 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 27565302
[Au] Autor:Colloby SJ; Field RH; Wyper DJ; O'Brien JT; Taylor JP
[Ad] Address:Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK. Electronic address: sean.colloby@ncl.ac.uk.
[Ti] Title:A spatial covariance I-5IA-85380 SPECT study of α4ß2 nicotinic receptors in Alzheimer's disease.
[So] Source:Neurobiol Aging;47:83-90, 2016 Nov.
[Is] ISSN:1558-1497
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Alzheimer's disease (AD) is characterized by widespread degeneration of cholinergic neurons, particularly in the basal forebrain. However, the pattern of these deficits and relationship with known brain networks is unknown. In this study, we sought to clarify this and used I-5-iodo-3-[2(S)-2-azetidinylmethoxy] pyridine ( 5IA-85380) single photon emission computed tomography to investigate spatial covariance of α4ß2 nicotinic acetylcholine receptors in AD and healthy controls. Thirteen AD and 16 controls underwent 5IA-85380 and regional cerebral blood flow ( Tc-exametazime) single photon emission computed tomography scanning. We applied voxel principal component (PC) analysis, generating series of principal component images representing common intercorrelated voxels across subjects. Linear regression generated specific α4ß2 and regional cerebral blood flow covariance patterns that differentiated AD from controls. The α4ß2 pattern showed relative decreased uptake in numerous brain regions implicating several networks including default mode, salience, and Papez hubs. Thus, as well as basal forebrain and brainstem cholinergic system dysfunction, cholinergic deficits mediated through nicotinic acetylcholine receptors could be evident within key networks in AD. These findings may be important for the pathophysiology of AD and its associated cognitive and behavioral phenotypes.
[Mh] MeSH terms primary: Alzheimer Disease/diagnostic imaging
Alzheimer Disease/metabolism
Azetidines
Prosencephalon/diagnostic imaging
Prosencephalon/metabolism
Pyridines
Radiopharmaceuticals
Receptors, Nicotinic/metabolism
Tomography, Emission-Computed, Single-Photon
[Mh] MeSH terms secundary: Aged
Aged, 80 and over
Alzheimer Disease/etiology
Cerebrovascular Circulation
Female
Humans
Male
Technetium Tc 99m Exametazime
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (5-iodo-3-(2-azetidinylmethoxy)pyridine); 0 (Azetidines); 0 (Pyridines); 0 (Radiopharmaceuticals); 0 (Receptors, Nicotinic); 0 (nicotinic receptor alpha4beta2); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Entry month:1710
[Cu] Class update date: 171017
[Lr] Last revision date:171017
[Js] Journal subset:IM
[Da] Date of entry for processing:160828
[St] Status:MEDLINE

  6 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 27246971
[Au] Autor:Espinosa P; Spriet M; Sole A; Walker NJ; Vaughan B; Galuppo LD
[Ad] Address:Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, Davis, California.
[Ti] Title:Scintigraphic Tracking of Allogeneic Mesenchymal Stem Cells in the Distal Limb After Intra-Arterial Injection in Standing Horses.
[So] Source:Vet Surg;45(5):619-24, 2016 Jul.
[Is] ISSN:1532-950X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To assess the feasibility of intra-arterial administration of allogeneic mesenchymal stem cells (MSC) in the median artery of standing horses and evaluate the distribution and retention of radiolabeled cells. STUDY DESIGN: In vivo experimental study. ANIMALS: Six research horses. METHODS: Technetium(99m) -HexaMethyl-Propylene-Amine Oxime-labeled MSC were injected under ultrasound guidance in the median artery of 6 front limbs of 3 horses, standing under sedation. Scintigraphic images were obtained at the time of injection, and at 1, 6, and 24 hours postinjection. Six additional limbs from 3 horses were similarly injected with unlabeled MSC. Ultrasound was performed the following day for assessment of vascular changes. RESULTS: Intra-arterial injection was performed successfully in 11 of 12 limbs. In 1 limb, partial periarterial injection compromised the success of the procedure. Homogeneous distribution of radiolabeled MSC was observed through the entire distal limb, including within the hoof. Partial venous thrombosis was found in both groups of horses, but was subjectively less severe in horses injected with unlabeled MSC. No lameness was observed. Transient swelling of the distal limb occurred in only 1 limb. CONCLUSION: Intra-arterial injection of MSC can be performed in standing horses under sedation and successfully distribute MSC to the distal limb. A risk of periarterial injection was identified but can be reduced with proper sedation, local anesthesia, and increased experience. Partial venous thrombosis was observed as a complication, but did not cause changes of clinical importance, other than rare transient swelling.
[Mh] MeSH terms primary: Arteries/diagnostic imaging
Horses
Mesenchymal Stem Cell Transplantation/veterinary
Radiopharmaceuticals/pharmacokinetics
Technetium Tc 99m Exametazime/pharmacokinetics
[Mh] MeSH terms secundary: Animals
Hindlimb/blood supply
Hindlimb/diagnostic imaging
Injections, Intra-Arterial/veterinary
Radionuclide Imaging/veterinary
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Entry month:1612
[Cu] Class update date: 161230
[Lr] Last revision date:161230
[Js] Journal subset:IM
[Da] Date of entry for processing:160602
[St] Status:MEDLINE
[do] DOI:10.1111/vsu.12485

  7 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 27179747
[Au] Autor:Lezaic L; Socan A; Peitl PK; Poglajen G; Sever M; Cukjati M; Cernelc P; Vrtovec B
[Ad] Address:Department for Nuclear Medicine, UMC Ljubljana, Slovenia. Electronic address: luka.lezaic@kclj.si.
[Ti] Title:Imaging and 1-day kinetics of intracoronary stem cell transplantation in patients with idiopathic dilated cardiomyopathy.
[So] Source:Nucl Med Biol;43(7):410-4, 2016 Jul.
[Is] ISSN:1872-9614
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Stem cell transplantation is an emerging method of treatment for patients with cardiovascular disease. There are few studies completed or ongoing on stem cell therapy in patients with idiopathic dilated cardiomyopathy (IDCM). Information on stem cell homing and distribution in the myocardium after transplantation might provide important insight into effectiveness of transplantation procedure. AIM: To assess early engraftment, retention and migration of intracoronarily transplanted stem cells in the myocardium of patients with advanced dilated cardiomyopathy of non-ischaemic origin using stem cell labeling with (99m)Tc-exametazime (HMPAO). MATERIALS, METHODS: Thirty-five patients with IDCM and advanced heart failure were included in the study. Autologous hematopoietic (CD34+) stem cells were harvested by peripheral blood apheresis after bone marrow stimulation, labeled with (99m)Tc-HMPAO, tested for viability and injected into coronary vessel supplying areas of myocardium selected by myocardial perfusion scintigraphy as dysfunctional yet viable. Imaging was performed 1h and 18h after transplantation. RESULTS: Myocardial stem cell retention ranged from 0 to 1.44% on early and 0-0.97% on delayed imaging. Significant efflux of stem cells occurred from site of delivery in this time period (p<0.001). Stem cell viability was not affected by labeling. CONCLUSION: Stem cell labeling with (99m)Tc-HMPAO is a feasible method for stem cell tracking after transplantation in patients with IDCM.
[Mh] MeSH terms primary: Cardiomyopathy, Dilated/diagnostic imaging
Cardiomyopathy, Dilated/surgery
Coronary Vessels/surgery
Stem Cell Transplantation
[Mh] MeSH terms secundary: Adult
Cell Movement
Cell Survival
Female
Humans
Kinetics
Male
Stem Cells/cytology
Stem Cells/metabolism
Technetium Tc 99m Exametazime/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Entry month:1711
[Cu] Class update date: 171106
[Lr] Last revision date:171106
[Js] Journal subset:IM
[Da] Date of entry for processing:160516
[St] Status:MEDLINE

  8 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 27117205
[Au] Autor:Maucksch U; Runge R; Wunderlich G; Freudenberg R; Naumann A; Kotzerke J
[Ad] Address:a University Hospital/Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden , Department of Nuclear Medicine , Dresden , Germany.
[Ti] Title:Comparison of the radiotoxicity of the Tc-labeled compounds Tc-pertechnetate, Tc-HMPAO and Tc-MIBI.
[So] Source:Int J Radiat Biol;92(11):698-706, 2016 Nov.
[Is] ISSN:1362-3095
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: In addition to gamma radiation, Tc emits low-energy Auger electrons with path-lengths of nanometers to micrometers that cannot be utilized for diagnostic procedures; however, they have frequently been discussed for therapeutic applications. We compared radiotoxicity of three Tc-labeled radiopharmaceuticals with differences in the subcellular distribution. MATERIALS AND METHODS: The intracellular radionuclide uptake and subcellular distribution of [ Tc]-pertechnetate ( Tc-pertechnetate), [ Tc]Tc-hexamethyl-propylene-aminoxime ( Tc-HMPAO) and [ Tc]Tc-hexakis-2-methoxyisobutylisonitrile ( Tc-MIBI) were quantified in rat thyroid FRTL-5 cells. Radiotoxicity was compared using late phosphorylated histone H2AX (γH2AX) foci as a marker for unrepaired DNA double-strand breaks (DNA-DSB) and clonogenic cell survival. RESULTS: Tc-HMPAO showed a substantially higher uptake into the nucleus and the membrane/organelles than Tc-pertechnetate or Tc-MIBI. The colony-forming assay showed that Tc-pertechnetate and Tc-HMPAO caused a similar reduction in cell survival. Tc-MIBI is less radiotoxic in terms of the estimated nucleus dose and induced the fewest number of γH2AX foci compared with the other Tc-tracers, and Tc-HMPAO induced a fewer number of γH2AX foci than Tc-pertechnetate. CONCLUSIONS: Our findings reveal that clonogenic cellular survival is not solely determined by the DNA-DSB response. This finding may suggest the involvement of extra-nuclear radiosensitive targets in cell inactivation. For example, the mitochondria or the cell membrane could be affected by Tc-HMPAO.
[Mh] MeSH terms primary: Technetium Compounds/pharmacokinetics
Technetium Compounds/therapeutic use
Thyroid Neoplasms/metabolism
Thyroid Neoplasms/radiotherapy
[Mh] MeSH terms secundary: Animals
Cell Line, Tumor
Cell Survival/radiation effects
Dose-Response Relationship, Radiation
Isotope Labeling
Radiopharmaceuticals/pharmacokinetics
Radiopharmaceuticals/therapeutic use
Radiotherapy Dosage
Rats
Sodium Pertechnetate Tc 99m/pharmacokinetics
Sodium Pertechnetate Tc 99m/therapeutic use
Technetium Tc 99m Exametazime/pharmacokinetics
Technetium Tc 99m Exametazime/therapeutic use
Technetium Tc 99m Sestamibi/pharmacokinetics
Technetium Tc 99m Sestamibi/therapeutic use
Thyroid Neoplasms/pathology
[Pt] Publication type:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 0 (Technetium Compounds); 3B744AG22N (Technetium Tc 99m Exametazime); 971Z4W1S09 (Technetium Tc 99m Sestamibi); A0730CX801 (Sodium Pertechnetate Tc 99m)
[Em] Entry month:1707
[Cu] Class update date: 170713
[Lr] Last revision date:170713
[Js] Journal subset:IM; S
[Da] Date of entry for processing:160428
[St] Status:MEDLINE

  9 / 2924 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 27111811
[Au] Autor:Doruyter A; Lochner C; Jordaan GP; Stein DJ; Dupont P; Warwick JM
[Ad] Address:Division of Nuclear Medicine, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: doruyter@sun.ac.za.
[Ti] Title:Resting functional connectivity in social anxiety disorder and the effect of pharmacotherapy.
[So] Source:Psychiatry Res;251:34-44, 2016 May 30.
[Is] ISSN:1872-7123
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Neuroimaging research has reported differences in resting-state functional connectivity (RFC) between social anxiety disorder (SAD) patients and healthy controls (HCs). Limited research has examined the effect of treatment on RFC in SAD. We performed a study to identify differences in RFC between SAD and HC groups, and to investigate the effect of pharmacotherapy on RFC in SAD. Seed-based RFC analysis was performed on technetium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO) SPECT scans using a cross-subject approach in SPM-12. Seeds were chosen to represent regions in a recently published network model of SAD. A second-level regression analysis was performed to further characterize the underlying relationships identified in the group contrasts. Twenty-three SAD participants were included, of which 18 underwent follow-up measures after an 8-week course of citalopram or moclobemide. Fifteen healthy control (HC) scans were included. SAD participants at baseline demonstrated several significant connectivity disturbances consistent with the existing network model as well as one previously unreported finding (increased connectivity between cerebellum and posterior cingulate cortex). After therapy, the SAD group demonstrated significant increases in connectivity with dorsal anterior cingulate cortex which may explain therapy-induced modifications in how SAD sufferers interpret emotions in others and improvements in self-related and emotional processing.
[Mh] MeSH terms primary: Brain/diagnostic imaging
Citalopram/therapeutic use
Moclobemide/therapeutic use
Phobia, Social/diagnostic imaging
Phobia, Social/drug therapy
Tomography, Emission-Computed, Single-Photon/methods
[Mh] MeSH terms secundary: Adult
Antidepressive Agents/pharmacology
Antidepressive Agents/therapeutic use
Brain/drug effects
Brain/physiology
Citalopram/pharmacology
Emotions/drug effects
Emotions/physiology
Female
Gyrus Cinguli/physiopathology
Humans
Male
Moclobemide/pharmacology
Neuroimaging/methods
Phobia, Social/psychology
Rest/physiology
Technetium Tc 99m Exametazime
Treatment Outcome
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antidepressive Agents); 0DHU5B8D6V (Citalopram); 3B744AG22N (Technetium Tc 99m Exametazime); PJ0Y7AZB63 (Moclobemide)
[Em] Entry month:1711
[Cu] Class update date: 171108
[Lr] Last revision date:171108
[Js] Journal subset:IM
[Da] Date of entry for processing:160426
[St] Status:MEDLINE

  10 / 2924 MEDLINE  
              first record previous record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 27017602
[Au] Autor:Kameyama M; Murakami K; Jinzaki M
[Ad] Address:Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. kame-tky@umin.ac.jp.
[Ti] Title:Optimal HMPAO α value for Lassen's correction algorithm obscured by statistical noise.
[So] Source:Ann Nucl Med;30(6):445-9, 2016 Jul.
[Is] ISSN:1864-6433
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:OBJECTIVE: [(99m)Tc] D,L-hexamethyl-propyeneamine oxime ((99m)Tc-HMPAO), a brain perfusion tracer, suffers significant underestimation of regional cerebral blood flow (rCBF). Lassen et al. developed their linearization algorithm to correct the influence of back-diffusion of the tracer, and proposed their parameter α as 1.5. Based on mathematical modeling and literature review, recently, a new α value of 0.5 has been proposed for Lassen's correction algorithm for (99m)Tc-HMPAO, although correction using the old α value of 1.5 was confirmed to be sufficient. Inugami et al. reported that linearization correction gives a stable correlation coefficient over a wide range of α. Our hypotheses are that statistical noise is the source of the stable correlation coefficient presented by them and that the robustness of the correlation coefficient is the reason why many studies confirmed the value of α as 1.5. METHODS: Statistical noise was added in silico to the count, whose relationship with flow was α = 0.5. Then, the count was corrected by Lassen's linearization algorithm with a variety of α. RESULTS: This study confirmed the hypothesis that smaller α values (strong correction) increase the noise at high flow values, leading to nominal increases in correlation coefficient as α decreases. CONCLUSION: Despite this, adoption of the new, smaller α value of 0.5 would be more useful clinically in regaining the contrast between low-flow and high-flow areas of the brain.
[Mh] MeSH terms primary: Algorithms
Image Processing, Computer-Assisted
Signal-To-Noise Ratio
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon/methods
[Mh] MeSH terms secundary: Brain/blood supply
Brain/diagnostic imaging
Cerebrovascular Circulation
Models, Theoretical
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:3B744AG22N (Technetium Tc 99m Exametazime)
[Em] Entry month:1701
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Js] Journal subset:IM
[Da] Date of entry for processing:160328
[St] Status:MEDLINE
[do] DOI:10.1007/s12149-016-1073-z


page 1 of 293 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information