Database : MEDLINE
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[PMID]: 29523036
[Au] Autor:Rajpoot J; Sahani N; Zaheer S; Dhawan I
[Ad] Address:a Vardhman Mahavir Medical College & Safdarjung Hospital , New Delhi , India.
[Ti] Title:Immature ovarian teratoma with gliomatosis peritonei with adenocarcinomatous differentiation in one of the lymph node's metastasis.
[So] Source:J Obstet Gynaecol;:1-2, 2018 Mar 09.
[Is] ISSN:1364-6893
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1080/01443615.2017.1405248

  2 / 18838 MEDLINE  
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[PMID]: 29429175
[Au] Autor:Peng Z; Wang ZX; Xie J; Wang LE; Liu Y; Gong SS
[Ad] Address:Department of Otorhinolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijng 100050, China.
[Ti] Title:[Middle ear teratoma in infant: report of three cases and review of the literatures].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(2):81-85, 2018 Feb 07.
[Is] ISSN:1673-0860
[Cp] Country of publication:China
[La] Language:chi
[Ab] Abstract:To summarize the clinical characteristics and therapeutic experiences of the middle ear teratoma in infants. Three cases of middle ear teratoma, from 2012-2015 in Beijing Friendship Hospital were analyzed. The three cases all developed slowly and presented unilateral otorrhea and hearing loss. Otoscopy showed the granulation tissue in the external ear canal. Audiological changes varied according to the degree of severity. Imaging features showed the pocket-like occupancy lesions in the Eustachian tube area. The temporal bone CT showed mass with soft tissue density usually involved in the mastoid and tympanic cavity. MRI showed mixed signal intense on both T1 and T2 weighted imaging. All the three cases received neoplasm resection of the middle ear. Only one case received tympanoplasty surgery at the same time. And all the pathology results displayed mature teratoma. The follow-up time was 17 to 54 months. MRI showed complete removal of the tumor. Teratoma are rare in the head and neck neoplasm. When the infants suffer from the unilateral otorrhea, hearing loss, and granulation tissue formed in the external ear canal, it should be vigilant for teratoma. The differential diagnosis is middle ear cholesteatoma, congenital first branchial cyst or fistula, and middle ear carcinoma. Temporal bone CT combined with MRI could improve the accuracy of diagnosis. It should be totally resection as soon as possible if there is no contraindication. Postoperative follow-up and imaging examination are necessary to eliminate tumor recurrence.
[Mh] MeSH terms primary: Ear Neoplasms/surgery
Ear, Middle
Teratoma
[Mh] MeSH terms secundary: Branchioma
Deafness/etiology
Diagnosis, Differential
Ear Neoplasms/complications
Ear Neoplasms/diagnostic imaging
Ear, Middle/diagnostic imaging
Eustachian Tube/diagnostic imaging
Head and Neck Neoplasms
Humans
Infant
Magnetic Resonance Imaging
Mastoid/diagnostic imaging
Neoplasm Recurrence, Local
Otoscopy
Temporal Bone/diagnostic imaging
Teratoma/complications
Teratoma/diagnostic imaging
Teratoma/surgery
Tomography, X-Ray Computed
Tympanoplasty
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[Js] Journal subset:IM
[Da] Date of entry for processing:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.02.001

  3 / 18838 MEDLINE  
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[PMID]: 29513076
[Au] Autor:Lwanga A; Kamson DO; Wilkins TE; Sharma V; Schulte JJ; Miller J; Hassan I; Lastra RR
[Ad] Address:1 Division of Academic Internal Medicine and Geriatrics, University of Illinois, Chicago IL USA.
[Ti] Title:Occult teratoma in a case of N-methyl-D-aspartate receptor encephalitis.
[So] Source:Neuroradiol J;:1971400918763578, 2018 Jan 01.
[Is] ISSN:2385-1996
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:N-methyl-D-aspartate receptor encephalitis (NMDARe) is one of 13 autoimmune-mediated encephalitides that have been discovered over the last decade. This case report describes the course of a 26-year-old female who presented with new-onset seizures and insomnia, complicated by encephalitis. The initial workup ruled out common causes of encephalitis, while a transvaginal ultrasound (TVUS), and computed tomography (CT) scans of the chest, abdomen, and pelvis did not identify a mass. Based on the suspicion that she may have autoimmune encephalitis, the patient was treated with intravenous immunoglobulins and plasma exchange, but continued to deteriorate. Whole-body positron emission tomography (PET) scan identified a small hypermetabolic pelvic mass. Shortly thereafter serum and cerebral spinal fluid NMDAR antibody titers were reported as positive, prompting repetition of the TVUS, which confirmed the presence of an ovarian teratoma. The patient had a laparoscopic oophorectomy with subsequent resolution of her symptoms, further confirming the diagnosis. Despite the sensitivities of TVUS and CT of up to 94% and 98%, respectively, the teratoma was unusually small, necessitating the addition of a PET scan to identify the lesion. These neoplasms are thought to have low uptake on PET; however, it is possible that focal inflammation may have enhanced the detection. It is unlikely that the teratoma grew during hospitalization as the average growth rate is 1.8 mm per year. Regardless, the lesson that can be learned is that imaging modalities beyond CT and TVUS, such as PET, can be helpful, as identification of a resectable tumor may alter management and ultimately improve outcomes.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1177/1971400918763578

  4 / 18838 MEDLINE  
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[PMID]: 29393405
[Au] Autor:Ohmine S; Salisbury JL; Ingle J; Pettinato G; Haddox CL; Haddad T; Galanis E; Ikeda Y; D'assoro AB
[Ad] Address:Department of Molecular Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
[Ti] Title:Aurora-A overexpression is linked to development of aggressive teratomas derived from human iPS cells.
[So] Source:Oncol Rep;39(4):1725-1730, 2018 Apr.
[Is] ISSN:1791-2431
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:The discovery of human induced pluripotent stem cells (hiPSCs) is a promising advancement in the field of regenerative and personalized medicine. Expression of SOX2, KLF4, OCT4 and MYC transcription factors induces the nuclear reprogramming of somatic cells into hiPSCs that share striking similarities with human embryonic stem cells (hESCs). However, several studies have demonstrated that hESCs and hiPSCs could lead to teratoma formation invivo, thus limiting their current clinical applications. Aberrant cell cycle regulation of hESCs is linked to centrosome amplification, which may account, for their enhanced chromosomal instability (CIN), and thus increase their tumorigenicity. Significantly, the tumor suppressor p53 plays a key role as a 'guardian of reprogramming', safeguarding genomic integrity during hiPSC reprogramming. Nevertheless, the molecular mechanisms leading to development of CIN during reprogramming and increased tumorigenic potential of hiPSCs remains to be fully elucidated. In the present study, we analyzed CIN in hiPSCs derived from keratinocytes and established that chromosomal and mitotic aberrations were linked to centrosome amplification, Aurora-A overexpression, abrogation of p53-mediated G1/S cell cycle checkpoint and loss of Rb tumor-suppressor function. When hiPSCs were transplanted into the kidney capsules of immunocompromised mice, they developed high-grade teratomas characterized by the presence of cells that exhibited non-uniform shapes and sizes, high nuclear pleomorphism and centrosome amplification. Significantly, exvivo cells derived from teratomas exhibited high self-renewal capacity that was linked to Aurora-A kinase activity and gave rise to lung metastasis when injected into the tail vein of immunocompromised mice. Collectively, these findings demonstrated a high risk for malignancy of hiPSCs that exhibit Aurora-A overexpression, loss of Rb function, centrosome amplification and CIN. Based on these findings, we proposed that Aurora-A-targeted therapy could represent a promising prophylactic therapeutic strategy to decrease the likelihood of CIN and development of aggressive teratomas derived from hiPSCs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.3892/or.2018.6239

  5 / 18838 MEDLINE  
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[PMID]: 29269272
[Au] Autor:Ladenhauf HN; Brandtner MG; Schimke C; Ardelean MA; Metzger R
[Ad] Address:Department of Pediatric and Adolescent Surgery, Paracelsus Medical University, Salzburg, Austria. Electronic address: h.ladenhauf@salk.at.
[Ti] Title:Sacrococcygeal Teratoma Presenting with Vaginal Discharge and Polyp in an Infant.
[So] Source:J Pediatr Adolesc Gynecol;, 2017 Dec 18.
[Is] ISSN:1873-4332
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Sacrococcygeal teratoma accounts for the most common solid tumor in neonates. Because of improved technology, 50%-70% of cases can be diagnosed antenatally during routine ultrasound screenings. If not diagnosed antenatally, clinical findings at birth are distinct in most cases including a palpable or visible mass. CASE: We report an unusual case of a 1-year-old girl who presented with persistent vaginal discharge leading to diagnosis of a mucosal polypoid lesion of the vagina, ultimately revealing a hidden sacrococcygeal teratoma. SUMMARY AND CONCLUSION: We suggest thorough investigation of all infants who present with purulent discharge and recurrent vaginal mass; sacrococcygeal teratoma should routinely be considered as a differential diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:Publisher

  6 / 18838 MEDLINE  
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[PMID]: 29487310
[Au] Autor:Sougawa N; Miyagawa S; Fukushima S; Kawamura A; Yokoyama J; Ito E; Harada A; Okimoto K; Mochizuki-Oda N; Saito A; Sawa Y
[Ad] Address:Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
[Ti] Title:Immunologic targeting of CD30 eliminates tumourigenic human pluripotent stem cells, allowing safer clinical application of hiPSC-based cell therapy.
[So] Source:Sci Rep;8(1):3726, 2018 Feb 27.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating from undifferentiated iPSCs contaminating the graft is a critical concern for clinical application. Here, we hypothesized that brentuximab vedotin, which targets CD30, induces apoptosis in tumourigenic cells, thus increasing the safety of iPSC therapy for heart failure. Flow cytometry analysis identified consistent expression of CD30 in undifferentiated human iPSCs. Addition of brentuximab vedotin in vitro for 72 h efficiently induced cell death in human iPSCs, associated with a significant increase in G2/M phase cells. Brentuximab vedotin significantly reduced Lin28 expression in cardiomyogenically differentiated human iPSCs. Transplantation of human iPSC-derived cardiomyocytes (CMs) without treatment into NOG mice consistently induced teratoma/tumour formation, with a substantial number of Ki-67-positive cells in the graft at 4 months post-transplant, whereas iPSC-derived CMs treated with brentuximab vedotin prior to the transplantation did not show teratoma/tumour formation, which was associated with absence of Ki-67-positive cells in the graft over the same period. These findings suggest that in vitro treatment with brentuximab vedotin, targeting the CD30-positive iPSC fraction, reduced tumourigenicity in human iPSC-derived CMs, potentially providing enhanced safety for iPSC-based cardiomyogenesis therapy in clinical scenarios.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-21923-8

  7 / 18838 MEDLINE  
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[PMID]: 29356973
[Au] Autor:Kaneko A; Kaneko J; Tominaga N; Kanazawa N; Hattori K; Ugawa Y; Moriya A; Kuzume D; Ishima D; Kitamura E; Nishiyama K; Iizuka T
[Ad] Address:Department of Neurology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
[Ti] Title:Pitfalls in clinical diagnosis of anti-NMDA receptor encephalitis.
[So] Source:J Neurol;265(3):586-596, 2018 Mar.
[Is] ISSN:1432-1459
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To report pitfalls in the clinical diagnosis of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. METHODS: We retrospectively reviewed the clinical information of 221 patients with clinically suspected autoimmune neurological disorders who underwent testing for autoantibodies against neuronal cell-surface antigens between January 1, 2007 and September 10, 2017. Forty-one patients met the diagnostic criteria for probable anti-NMDAR encephalitis (probable criteria), but one was excluded because neither serum nor CSF was examined at the active stage. Thus, in 220 patients, sensitivity and specificity of the probable criteria were assessed. RESULTS: NMDAR-antibodies were detected in 34 of 40 patients (85%) with the probable criteria; however, 2 of the 6 antibody-negative patients had ovarian teratoma. The median age at onset was higher in antibody-negative patients than those with antibodies (49 vs. 27years, p=0.015). The age at onset was associated with the probability of antibody detection (p=0.014); the probability was less than 50% in patients aged 50years or older. NMDAR-antibodies were also detected in 5 of 180 patients who did not fulfill the probable criteria; these patients presented with isolated epileptic syndrome (n=2), atypical demyelinating syndrome (n=2; one with aquaporin 4 antibodies), and autoimmune post-herpes simplex encephalitis (post-HSE) (n=1). Sensitivity and specificity of the probable criteria was 87.2 and 96.7%, respectively. CONCLUSION: The probable criteria are valid, but the diversity of clinical phenotype should be taken into account in diagnosing anti-NMDAR encephalitis particularly in patients aged 50years or older, or with isolated epileptic syndrome, atypical demyelinating syndrome, or post-HSE.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:In-Process
[do] DOI:10.1007/s00415-018-8749-3

  8 / 18838 MEDLINE  
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[PMID]: 29495013
[Au] Autor:Gebb JS; Khalek N; Qamar H; Johnson MP; Oliver ER; Coleman BG; Peranteau WH; Hedrick HL; Flake AW; Adzick NS; Moldenhauer JS
[Ti] Title:High Tumor Volume to Fetal Weight Ratio Is Associated with Worse Fetal Outcomes and Increased Maternal Risk in Fetuses with Sacrococcygeal Teratoma.
[So] Source:Fetal Diagn Ther;, 2018 Mar 01.
[Is] ISSN:1421-9964
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Tumor volume to fetal weight ratio (TFR) > 0.12 before 24 weeks has been associated with poor outcome in fetuses with sacrococcygeal teratoma (SCT). We evaluated TFR in predicting poor fetal outcome and increased maternal operative risk in our cohort of SCT pregnancies. METHODS: This is a retrospective, single-center review of fetuses seen with SCT from 1997 to 2015. Patients who chose termination of pregnancy (TOP), delivered elsewhere, or had initial evaluation at > 24 weeks were excluded. Receiver operating characteristic (ROC) analysis determined the optimal TFR to predict poor fetal outcome and increased maternal operative risk. Poor fetal outcome included fetal demise, neonatal demise, or fetal deterioration warranting open fetal surgery or delivery < 32 weeks. Increased maternal operative risk included cases necessitating open fetal surgery, classical cesarean delivery, or ex utero intrapartum treatment (EXIT). RESULTS: Of 139 pregnancies with SCT, 27 chose TOP, 14 delivered elsewhere, and 40 had initial evaluation at > 24 weeks. Thus, 58 fetuses were reviewed. ROC analysis revealed that at ≤24 weeks, TFR > 0.095 was predictive of poor fetal outcome and TFR > 0.12 was predictive of increased maternal operative risk. CONCLUSION: This study supports the use of TFR at ≤24 weeks for risk stratification of pregnancies with SCT.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[St] Status:Publisher
[do] DOI:10.1159/000486782

  9 / 18838 MEDLINE  
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[PMID]: 29390326
[Au] Autor:Wang M; Jiang S; Zhang Y; Jiang C; Xia F; Lyu W; Ma X
[Ad] Address:Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center.
[Ti] Title:The application of 18F-FDG PET/CT in ovarian immature teratomas when pathological examination results contradict clinical observations: a case report.
[So] Source:Medicine (Baltimore);96(50):e9171, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could reveal potential lymph node involvement and assisted locating sample sites for pathological examinations. PATIENT CONCERNS: Help choose the right treatment strategies for patients. To better stage immature ovarian teratomas with 18F-FDG PET/CT when lymphatic metastasis is suspected while lymph node biopsy results are negative. DIAGNOSES: The ultimate pathological diagnosis was left ovarian cancer, an immature teratoma (IMT) Grade 1. INTERVENTIONS: Surgery was the initial treatment option. Chemotherapy (BEP scheme: Bleomycin 30 mg d1, 7 + Etoposide 100mg d1-6 + Cisplatin 50mg d1-3) was then administered. OUTCOMES: The post-operational pathological examination additionally showed a small number of tumor cells in para-aortic lymph nodes. The end-of-treatment disclosed no recurrent tumors and serum levels of AFP (2.9 ng/mL), hCG (0.12 mIU/L), and CA-125 (11.4 IU/mL) were normal. LESSONS: 18F-FDG PET/CT successfully detected lymphatic metastasis when lymph node biopsy results were negative, which would be of great significance in detecting metastasis and monitoring reoccurrence of ovarian immature teratomas.
[Mh] MeSH terms primary: Ovarian Neoplasms/diagnostic imaging
Ovarian Neoplasms/pathology
Positron Emission Tomography Computed Tomography
Teratoma/diagnostic imaging
Teratoma/pathology
[Mh] MeSH terms secundary: Adolescent
Combined Modality Therapy
Female
Fluorodeoxyglucose F18
Humans
Lymphatic Metastasis/diagnostic imaging
Ovarian Neoplasms/therapy
Radiopharmaceuticals
Teratoma/therapy
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Entry month:1802
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009171

  10 / 18838 MEDLINE  
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[PMID]: 29485697
[Au] Autor:Pranzatelli MR; Allison TJ; McGee NR; Tate ED
[Ad] Address:From the National Pediatric Myoclonus Center, Orlando, FL.
[Ti] Title:Cerebrospinal fluid γδ T cell frequency is age-related: a case control study of 435 children with inflammatory and non-inflammatory neurologic disorders.
[So] Source:Clin Exp Immunol;, 2018 Feb 27.
[Is] ISSN:1365-2249
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Studies of cerebrospinal fluid (CSF) γδ T cells in children are limited, especially due to the lack of control data. In adults, gamma/delta T cells (TCR-γδ) residing in the intrathecal space are sometimes involved in neuroinflammation. To evaluate the possible role of γδ T cells in pediatric neuroinflammation, we immunophenotyped CSF and blood lymphocytes using flow cytometry in a case-control study of 100 children with non-inflammatory neurologic disorders (NIND), 312 with opsoclonus-myoclonus (OMS), and 23 with other inflammatory neurologic disorders (OIND). In NIND, the negative correlation between CSF γδ T cell frequency and patient age was striking: median frequency 27% in infants, 3.3% in teens. Inter-individual variations were largest in the youngest. There was no gender effect. In all OMS, after correcting for age, only a small effect of OMS severity remained. Measurement of markers for γδ T cell activation (HLA-DR), maturation (CD45RA, CD45RO), or intracellular cytokine staining (IL-4, IFN-γ) failed to discriminate OMS and NIND groups. Of 7 OMS immunotherapies/combinations, none significantly altered the frequency of total CSF γδ T cells or subsets. In OIND, the CSF γδ T cell frequency was <10% for single samples of other paraneoplastic disorders (ANNA-1, ANNA-2, teratoma-associated syndrome), cerebellar ataxia (post-infectious, ataxia-telangiectasia), acute disseminated encephalomyelitis, neuroborreliosis, and encephalitis. This study provides new insights into CSF γδ T cells in the pediatric population. Though their role in CSF remains elusive, the negative age correlation, resistance to immunotherapy, and our age cut-off references for NIND are important findings for the design of future pediatric studies. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[St] Status:Publisher
[do] DOI:10.1111/cei.13122


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