Database : MEDLINE
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[PMID]: 28714099
[Au] Autor:Kawakami Y; Hirano S; Mitsui S; Kuyama M; Nishibu A; Anzawa K; Mochizuki T
[Ad] Address:Department of Dermatology, Okayama City Hospital, Okayama, Japan.
[Ti] Title:Case of inflammatory tinea corporis affecting the dorsal surface of the thumb in a nail salon technician.
[So] Source:J Dermatol;44(11):e294-e295, 2017 Nov.
[Is] ISSN:1346-8138
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1707
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[St] Status:In-Data-Review
[do] DOI:10.1111/1346-8138.13967

  2 / 10045 MEDLINE  
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[PMID]: 29087496
[Au] Autor:Sun PL; Lin YC; Wu YH; Kao PH; Ju YM; Fan YC
[Ad] Address:Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.
[Ti] Title:Tinea folliculorum complicating tinea of the glabrous skin: an important yet neglected entity.
[So] Source:Med Mycol;, 2017 Oct 26.
[Is] ISSN:1460-2709
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Dermatophytes are capable of infecting the skin and its appendages such as nails and hairs producing a variety of clinical conditions. Hair invasion by dermatophytes is a key feature of tinea capitis and tinea barbae but not of tinea of glabrous skin. In this project, we studied the clinico-mycological aspects of follicular involvement in patients with dermatophytosis of the glabrous skin. In total, 16 patients, eight males and eight females, were included in the study. All were adults except for one girl. The disease durations ranged from one month to more than ten years. Fourteen (78.5%) had multiple lesions, and most of them had undergone treatment with antifungals, antibiotics, or steroids. Dermoscopic examination showed infected hairs in the form of broken stubs, coily, curly, or as black dots on the surface of the lesions. Pathogens were either anthropophilic (seven cases of Trichophyton rubrum) or zoophilic (six cases Microsporum canis, three cases of the T. mentagrophytes). Patients responded well to oral griseofulvin or terbinafine, and topical antifungals. No antifungal resistance developed during the treatment course. Follicular involvement of glabrous skin is not as rare as previously thought and should be considered for systemic antifungal treatments.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171031
[Lr] Last revision date:171031
[St] Status:Publisher
[do] DOI:10.1093/mmy/myx086

  3 / 10045 MEDLINE  
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[PMID]: 29082569
[Au] Autor:Wollina U; Hansel G; Uhrlaß S; Krüger C; Schönlebe J; Hipler UC; Nenoff P
[Ad] Address:Department of Dermatology and Allergology, Municipal Hospital Dresden, Academic Teaching Hospital Friedrichstadt, Dresden, Germany.
[Ti] Title:Deep facial mycosis due to Trichophyton verrucosum - molecular genetic identification of the dermatophyte in paraffin-embedded tissue - case report and review of the literature.
[So] Source:Mycoses;, 2017 Oct 30.
[Is] ISSN:1439-0507
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Deep trichophytosis is relatively uncommon. The infection of the bearded area is also known as sycosis barbae or tinea barbae and can be caused by various fungal species, most often zoophilic fungi. We report on an 80-year-old male patient with severe sycosis barbae who had no animal contact and was treated with systemic antibiosis without improvement. Microbial and mycological investigations using swabs from oozing lesions revealed Staphylococcus hemolyticus and Candida parapsilosis. Histology demonstrated fungal elements in hair follicles. Paraffin-embedded material was subjected to further mycological analysis. For molecular diagnostics DNA was prepared from paraffin sections for real-time polymerase chain reaction (RT-PCR). For sequencing, DNA was isolated from paraffin-embedded skin tissue and the ITS region of the rDNA was selected. Sequencing of the ITS2 region of rRNA revealed a 100% accordance with Trichophyton (T.) verrucosum. Treatment with oral terbinafine achieved a complete remission. Sycosis barbae is an important differential diagnosis for infections of the bearded area. Nucleic acid amplification techniques (NAAT) are more and more used for direct examination of dermatophytes in clinical samples, e. g. T. verrucosum. NAAT are also used as culture confirmation tests for identification of rare dermatophytes like T. verrucosum. Today, singleplex and multiplex quantitative real-time PCR (qRT-PCR) assays for the detection of the most common dermatophytes including T. verrucosum in clinical specimens are available. Recently, an ITS2 PCR assay has been succefully used for direct detection of T. verrucosum in paraffin-embedded formalin fixed skin tissue. The PCR is fast and highly specific. The sensitivity of direct molecular detection of the dermatophytes both in native clinical material, and in paraffin-embedded skin tissue can been increased. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[St] Status:Publisher
[do] DOI:10.1111/myc.12719

  4 / 10045 MEDLINE  
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[PMID]: 28536129
[Au] Autor:Grijsen ML; de Vries HJC
[Ad] Address:Department of Dermatology (Grijsen), Leiden University Medical Center, Leiden; Department of Dermatology (de Vries), Academic Medical Center, University of Amsterdam; STI Outpatient Clinic (de Vries), Public Health Service Amsterdam, Amsterdam, The Netherlands m.l.grijsen@lumc.nl.
[Ti] Title:Kerion.
[So] Source:CMAJ;189(20):E725, 2017 05 23.
[Is] ISSN:1488-2329
[Cp] Country of publication:Canada
[La] Language:eng
[Mh] MeSH terms primary: Tinea Capitis/pathology
Tinea/pathology
[Mh] MeSH terms secundary: Child
Humans
Male
Tinea/therapy
Tinea Capitis/therapy
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170524
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.160665

  5 / 10045 MEDLINE  
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[PMID]: 28138872
[Au] Autor:Bouchara JP; Mignon B; Chaturvedi V
[Ad] Address:UNIV Bretagne-Loire, University of Angers, University of Brest, Host-Pathogen Interactions Study Group (EA 3142), Angers, France.
[Ti] Title:Dermatophytes and Dermatophytoses: A Thematic Overview of State of the Art, and the Directions for Future Research and Developments.
[So] Source:Mycopathologia;182(1-2):1-4, 2017 Feb.
[Is] ISSN:1573-0832
[Cp] Country of publication:Netherlands
[La] Language:eng
[Mh] MeSH terms primary: Arthrodermataceae/isolation & purification
Tinea/diagnosis
Tinea/drug therapy
[Mh] MeSH terms secundary: Animals
Antifungal Agents/isolation & purification
Antifungal Agents/pharmacology
Antifungal Agents/therapeutic use
Arthrodermataceae/classification
Arthrodermataceae/pathogenicity
Biomedical Research/trends
Host-Pathogen Interactions
Humans
Tinea/epidemiology
Tinea/microbiology
[Pt] Publication type:EDITORIAL
[Nm] Name of substance:0 (Antifungal Agents)
[Em] Entry month:1704
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[Js] Journal subset:IM
[Da] Date of entry for processing:170131
[St] Status:MEDLINE
[do] DOI:10.1007/s11046-017-0114-z

  6 / 10045 MEDLINE  
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[PMID]: 28101694
[Au] Autor:Dhib I; Khammari I; Yaacoub A; Hadj Slama F; Ben Saïd M; Zemni R; Fathallah A
[Ad] Address:Parasitology-Mycology Laboratory, Faculty of Medicine, Farhat Hached University Hospital, Mohamed El Karoui Street, 4002, Sousse, Tunisia. dhib.imen@yahoo.fr.
[Ti] Title:Relationship Between Phenotypic and Genotypic Characteristics of Trichophyton mentagrophytes Strains Isolated from Patients with Dermatophytosis.
[So] Source:Mycopathologia;182(5-6):487-493, 2017 Jun.
[Is] ISSN:1573-0832
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:According to epidemiological, clinical and mycological criteria, it has long been admitted that the Trichophyton mentagrophytes species includes two varieties: a zoophilic variety (var. mentagrophytes) and an anthropophilic variety (var. interdigitale) that involve the upper and the lower part of the body, respectively. The further application of molecular techniques to the characterization of dermatophyte strains showed that this classification is unreliable. The aim of our study was to assess the usefulness of PCR-RFLP (restriction fragment length polymorphism) and sequencing in the characterization of T. mentagrophytes strains taken from Tunisian patients. The study was carried out in 2008 in the laboratory of Parasitology-Mycology of Farhat Hached University Hospital, Sousse, Tunisia. A total of 133 strains were isolated from 133 patients addressed to the laboratory for dermatological lesions very evocative of dermatomycosis. Eighty strains were isolated from lesions located on the lower part of the body (onychomycosis, tinea pedis) and 53 strains from the upper part of the body (tinea capitis, tinea corporis). All strains were submitted to mycological examination (direct microscopic examination and culture on Sabouraud medium) and further investigated by using RFLP analysis of the PCR-amplified ITS1-5.8 s-ITS2 region of the ribosomal DNA and the MvaI restriction enzyme. In addition, 62 strains were further submitted to a sequencing of the ITS1-5.8 s-ITS2 region. On the basis of mycological criteria, all strains were diagnosed as T. mentagrophytes. All strains produced the same RFLP pattern and were identified as T. mentagrophytes interdigitale regardless of the location of lesions. Out of the 62 sequenced strains, 16 were found anthropophilic and 46 were zoophilic. In conclusion, all strains provisionally diagnosed as T. mentagrophytes on the basis of mycological criteria were shown to belong to T. interdigitale by using PCR-RFLP and sequencing irrespective of the site of lesions. The predominance of zoophilic strains needs further investigation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1701
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[St] Status:In-Process
[do] DOI:10.1007/s11046-017-0110-3

  7 / 10045 MEDLINE  
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[PMID]: 28004227
[Au] Autor:Su H; Li L; Cheng B; Zhu J; Zhang Q; Xu J; Zhu M
[Ad] Address:Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
[Ti] Title:Trichophyton rubrum Infection Characterized by Majocchi's Granuloma and Deeper Dermatophytosis: Case Report and Review of Published Literature.
[So] Source:Mycopathologia;182(5-6):549-554, 2017 Jun.
[Is] ISSN:1573-0832
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Infections caused by Trichophyton rubrum are very common in dermatological disease. It most often appears as superficial cutaneous mycosis, such as tinea manuum, tinea pedis, and tinea corporis. However, deep infection caused by T. rubrum was rarely reported. We describe a case of mixed type of deep infection caused by T. rubrum in a 45-year-old man with no significant immunodeficiency. This patient had a history of onychomycosis on the toenails without regular treatment for nearly 6 years. And, he had erythema, papule, and nodules on the submandibular area, neck, and chest for almost 1 year. After treated with intravenous infusion of cefotiam for 2 weeks, the lesion aggravated. The fungal direct microscopic examination of pyogenic fluid was positive, and the fungal cultures that produced reddish-brown and yellow pigment showed cottony, wooly, and white colony. After the DNA sequencing, it was identified as T. rubrum. We gave the patient oral terbinafine 250 mg per day and bifonazole cream for external use. Six months later, the patient's skin lesion was disappeared, and healthy nail growth was seen in two-thirds of nail bed. The terbinafine is effective against deep infection caused by T. rubrum.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1612
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[St] Status:In-Process
[do] DOI:10.1007/s11046-016-0099-z

  8 / 10045 MEDLINE  
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[PMID]: 27771883
[Au] Autor:Lopes G; Pinto E; Salgueiro L
[Ad] Address:CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Rua dos Bragas 289, 4050-123, Porto, Portugal.
[Ti] Title:Natural Products: An Alternative to Conventional Therapy for Dermatophytosis?
[So] Source:Mycopathologia;182(1-2):143-167, 2017 Feb.
[Is] ISSN:1573-0832
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The increased incidence of fungal infections, associated with the widespread use of antifungal drugs, has resulted in the development of resistance, making it necessary to discover new therapeutic alternatives. Among fungal infections, dermatophytoses constitute a serious public health problem, affecting 20-25 % of the world population. Medicinal plants represent an endless source of bioactive molecules, and their volatile and non-volatile extracts are clearly recognized for being the historical basis of therapeutic health care. Because of this, the research on natural products with antifungal activity against dermatophytes has considerably increased in recent years. However, despite the recognized anti-dermatophytic potential of natural products, often advantageous face to commercial drugs, there is still a long way to go until their use in therapeutics. This review attempts to summarize the current status of anti-dermatophytic natural products, focusing on their mechanism of action, the developed pharmaceutical formulations and their effectiveness in human and animal models of infection.
[Mh] MeSH terms primary: Antifungal Agents/pharmacology
Arthrodermataceae/drug effects
Biological Products/pharmacology
Tinea/drug therapy
[Mh] MeSH terms secundary: Animals
Antifungal Agents/isolation & purification
Antifungal Agents/therapeutic use
Biological Products/isolation & purification
Biological Products/therapeutic use
Drug Discovery/methods
Drug Discovery/trends
Humans
Phytochemicals/isolation & purification
Phytochemicals/pharmacology
Phytochemicals/therapeutic use
Plant Extracts/isolation & purification
Plant Extracts/pharmacology
Plant Extracts/therapeutic use
Plants/chemistry
Tinea/microbiology
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Antifungal Agents); 0 (Biological Products); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Entry month:1704
[Cu] Class update date: 171030
[Lr] Last revision date:171030
[Js] Journal subset:IM
[Da] Date of entry for processing:161023
[St] Status:MEDLINE
[do] DOI:10.1007/s11046-016-0081-9

  9 / 10045 MEDLINE  
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[PMID]: 29080318
[Au] Autor:Happle R; Kluger N
[Ad] Address:Department of Dermatology, Medical Center - University of Freiburg, Germany.
[Ti] Title:Koebner's sheep in Wolf's clothing: does the isotopic response exist as a distinct phenomenon?
[So] Source:J Eur Acad Dermatol Venereol;, 2017 Oct 28.
[Is] ISSN:1468-3083
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Until 1995, a case of psoriasis developing within the dermatome of a healed herpes zoster was taken as a Koebner phenomenon. In this year, however, the term "isotopic response" was introduced by Wolf et al. to describe "the occurrence of a new skin disorder at the site of another, unrelated and already healed skin disease", thus appearing "on apparently unaffected and healthy skin." Initially, the term was mainly related to herpes zoster, but today the name "Wolf's isotopic response" is used to include a plethora of other triggering factors such as healed cutaneous leishmaniasis, tinea, or varicella. For obvious reasons, such triggering factors cannot be taken as examples of "unaffected and healthy skin". Notably, the authors themselves have categorized the dermatome of a healed herpes zoster as a "vulnerable area". In a recent commentary, Wolf et al. have expanded the definition of healed skin diseases triggering an "isotopic response". They now included "scars, pigment changes, color changes or various other minimal changes by the first disease." Hence, there is no clear-cut criterion to distinguish the isotopic response from a Koebner reaction. Wolf et al. even argue that, if the triggered disorder precedes the appearance of generalized skin lesions, then it is not a Koebner reaction but "Wolf's isotopic response". In our view, such definition is unacceptable. All reactions of this kind represent examples of a Koebner phenomenon. Accordingly, the "isotopic response" should today be taken as a historical error. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171028
[Lr] Last revision date:171028
[St] Status:Publisher
[do] DOI:10.1111/jdv.14664

  10 / 10045 MEDLINE  
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[PMID]: 29067631
[Au] Autor:Uhrlaß S; Mayser P; Schwarz R; Koch D; Krüger C; Korfmann I; Nenoff P
[Ad] Address:Laboratory for Medical Microbiology, Mölbiser Hauptstraße 8, 04571, Rötha/OT Mölbis, Germany.
[Ti] Title:Dermatomycoses Due to Nannizzia praecox (Formerly Microsporum praecox) in Germany: Case Reports and Review of the Literature.
[So] Source:Mycopathologia;, 2017 Oct 24.
[Is] ISSN:1573-0832
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Nannizzia praecox, formerly known as Microsporum praecox, is a geophilic dermatophyte. Up to now 31 cases of human tinea have been reported in the literature, most of them with an inflammatory course. Three recent cases diagnosed in Germany within 1 year suggest that the fungus might be a more common cause of human dermatophytosis than reported so far. This might be based on the fact that N. praecox is often found in an equine environment and that horse riding is becoming more popular recently.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1710
[Cu] Class update date: 171025
[Lr] Last revision date:171025
[St] Status:Publisher
[do] DOI:10.1007/s11046-017-0213-x


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