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[PMID]: 29447400
[Au] Autor:Ongsri P; Bunyaratavej S; Leeyaphan C; Pattanaprichakul P; Ongmahutmongkol P; Komoltri C; Kulthanan K
[Ad] Address:Naval Medical Department, Queen Sirikit Hospital, Royal Thai Navy, 163, Sukhumvit Road, Phlutaluang, Sattahip, Chonburi Province 20180, Thailand.
[Ti] Title:Prevalence and Clinical Correlation of Superficial Fungal Foot Infection in Thai Naval Rating Cadets.
[So] Source:Mil Med;, 2018 Feb 13.
[Is] ISSN:1930-613X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Background: Superficial fungal foot infection is one of the most important dermatological diseases currently affecting military personnel. Many Thai naval rating cadets are found to suffer from superficial fungal foot infections and their sequels. Objective: To investigate prevalence, potent risk factors, responding pathogens and clinical correlation of superficial fungal foot infection in Thai naval rating cadets training in Naval rating school, Sattahip, Thailand. Materials and Methods: This cross-sectional study was performed in August 2015. Validated structured questionnaire was used regarding information about behaviors and clinical symptoms. Quality of life was assessed by Dermatology Quality of Life Index (DLQI) questionnaire and clinical presentation demonstrated by Athlete's foot severity score (AFSS). Laboratory investigations including direct microscopic examination and fungal culture were performed and recorded. All of the participants were informed and asked for their consent. Results: A total of 788 Thai naval rating cadets with a mean age of 19 yr were enrolled. There were 406 (51.5%) participants suspected of fungal skin infection from questionnaire screening. After clinical examination, 303 participants (38.5%) were found to have foot lesions (AFSS ≥1). Superficial fungal foot infection was diagnosed with microscopic examination and fungal culture in 57 participants, giving a point prevalence of 7.2%. Tinea pedis was diagnosed in 54 participants with the leading causative organism being Trichophyton mentagrophytes (52.8%). Other 3 participants were diagnosed as cutaneous candidiasis. Wearing combat shoes more than 8 h was found to be a predisposing factor (p = 0.029), taking a shower less than two times a day (p = 0.008), and wearing sandals during shower (p = 0.055) was found to be protective against infection. Most fungal feet infection cases noticed their feet abnormalities (p < 0.001) including scales (p < 0.001), vesicles (p = 0.003) and maceration at interdigital web spaces (p < 0.001). Mean DLQI in superficial fungal foot infection cases was 3.35. Participants who had foot lesions (AFSS ≥1) were concerned of their foots unpleasant odor demonstrated significantly higher mean DLQI than those without odor (4.2 vs. 2.28; p < 0.001). Conclusion: Superficial fungal foot infection is found as 7.2% of naval rating cadets. Wearing combat shoes more than 8 h was found to be a predisposing factor. In addition to skin manifestations including scales, vesicles, and maceration, superficial fungal foot infection also exhibited an unpleasant foot odor which affected quality of life. Self-foot-examination and life style modification should be promoted to prevent fungal infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1093/milmed/usx187

  2 / 1661 MEDLINE  
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[PMID]: 29191265
[Au] Autor:Gobbato AAM; Gobbato CARS; Moreno RA; Antunes NJ; De Nucci G
[Ti] Title:Dapaconazole versus ketoconazole in the treatment of interdigital tinea pedis.
[So] Source:Int J Clin Pharmacol Ther;56(1):31-33, 2018 Jan.
[Is] ISSN:0946-1965
[Cp] Country of publication:Germany
[La] Language:eng
[Mh] MeSH terms primary: Antifungal Agents/therapeutic use
Imidazoles/therapeutic use
Ketoconazole/therapeutic use
Tinea Pedis/drug therapy
[Mh] MeSH terms secundary: Adult
Female
Humans
Male
Middle Aged
Ointments
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethyl)benzyloxy)ethyl)-1H-imidazole); 0 (Antifungal Agents); 0 (Imidazoles); 0 (Ointments); R9400W927I (Ketoconazole)
[Em] Entry month:1803
[Cu] Class update date: 180301
[Lr] Last revision date:180301
[Js] Journal subset:IM
[Da] Date of entry for processing:171202
[St] Status:MEDLINE
[do] DOI:10.5414/CP203124

  3 / 1661 MEDLINE  
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[PMID]: 29462232
[Au] Autor:Hoffman LK; Raymond I; Kircik L
[Ti] Title:Treatment of Signs and Symptoms (Pruritus) of Interdigital Tinea Pedis With Econazole Nitrate Foam, 1.
[So] Source:J Drugs Dermatol;17(2):229-232, 2018 Feb 01.
[Is] ISSN:1545-9616
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Tinea pedis is the most common dermatophyte infection. Treatment is critical to alleviate pruritic symptoms, to reduce the risk for secondary bacterial infection, and to limit the spread of infection to other body sites or other individuals. The objective of this study was to compare the abilities of econazole nitrate topical foam, 1% and ketoconazole cream (2%) to reduce pruritus, thus improving quality of life, and to determine patient preference for the foam product versus the cream product in patients with interdigital tinea pedis. STUDY DESIGN: A single-center, investigator-blinded, observational pilot study was conducted to compare econazole nitrate topical foam (1%) to ketoconazole cream (2%). In this split-body study, 20 subjects received both econazole nitrate topical foam and ketoconazole cream and applied the medications daily to either the right or left foot for 14 days. Improvements in patient quality of life (pruritus) and patient preference were measured using the pruritus visual analog scale (VAS), Skindex-16, and patient preference questionnaires. RESULTS: Nineteen subjects completed the study and one subject was lost to follow-up. Reductions in VAS scores of econazole nitrate topical foam were significantly greater than those of ketoconazole cream, indicating the superiority of the econazole nitrate foam in reducing pruritus. Skindex-16 data showed significant reductions in total scores and individual domains, including patient symptom, emotional, and functional domains, by the final visit. Since each subject received both medications the questionnaire was not medication-specific. Responses to patient preference questionnaires showed that econazole nitrate topical foam,1% was rated as "good" or "excellent" in all measures assessed. One adverse event was noted. CONCLUSION: In patients with interdigital tinea pedis, application of econazole nitrate topical foam 1% twice daily for two weeks was clinically effective and significantly superior to ketoconazole cream 2% in reducing pruritus. J Drugs Dermatol. 2018;17(2):229-232.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:In-Process

  4 / 1661 MEDLINE  
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[PMID]: 29439839
[Au] Autor:Farokhipor S; Ghiasian SA; Nazeri H; Kord M; Didehdar M
[Ad] Address:Department of Microbiology, Islamic Azad University, Arak Branch, Arak, Iran.
[Ti] Title:Characterizing the clinical isolates of dermatophytes in Hamadan city, Central west of Iran, using PCR-RLFP method.
[So] Source:J Mycol Med;, 2018 Feb 11.
[Is] ISSN:1773-0449
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Dermatophytosis is one of the most common mycotic infections, which considered as a public health problem in the major of countries. This study evaluated the molecular epidemiology of dermatophytosis in patients referred to Farshchian hospital in Hamadan city with PCR-RFLP method. MATERIALS AND METHODS: Four hundred and five specimens from clinically suspected patients of dermatophytosis were collected and analyzed by direct microscopic and culture. The isolates were identified by PCR-RFLP method using the MvaI restriction enzyme. RESULTS: Of the 405 specimens, 88 specimens were positive in direct examination and culture. Among the patients, 64.8% were males and35.2% females. Tinea pedis (31.8%) was the most common type of dermatophytosis followed by tinea corporis (22.7%), tinea cruris (20.5%), tinea capitis (10.2%), tinea manuum (5.7%), tinea faciei (4.6%) and tinea unguium (4.6%). Trichophyton interdigitale (36.4%) was the most common isolate followed by Trichophyton rubrum (27.3%), Epidermophyton floccosum (17%), Trichophyton tonsurans (11.4%), Microsporum canis (4.5%), Microsporum gypseum (2.3%) and Trichophyton benhamiae (1.1%). CONCLUSION: Our finding showed that the anthropophilic dermatophyte species causing dermatophytosis are increasing, and molecular methods are reliable assays for accurse identification of dermatophyte species in epidemiological studies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:Publisher

  5 / 1661 MEDLINE  
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[PMID]: 29427797
[Au] Autor:Cannon J; Rajakaruna G; Dyer J; Carapetis J; Manning L
[Ad] Address:Telethon Kids Institute, University of Western Australia, Perth, Western Australia.
[Ti] Title:Severe lower limb cellulitis: defining the epidemiology and risk factors for primary episodes in a population-based case-control study.
[So] Source:Clin Microbiol Infect;, 2018 Feb 07.
[Is] ISSN:1469-0691
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To describe the epidemiology and risk factors for primary episodes of severe lower leg cellulitis (LLC). METHODS: A longitudinal cohort study using state-wide data linkage of adults presenting to Western Australian (WA) hospitals with a first ever LLC from January 2002 to December 2013. To determine risk factors, medical records from the index patient, together with comparable data from controls matched by age, sex, postcode and month of admission were extracted. RESULTS: During the period, 36,276 patients presented with their first episode of LLC. The incidence increased by 4.7% per annum, reaching 204.8 (95% CI 198.6-211.1) per 100,000 population by December 2013. ANALYSIS: of 29,062 case-control pairs showed several conditions with lower limb pathology were independently associated with LLC, including varicose veins (AOR 2.95, 95% CI 2.50-3.48, p<0.001), lymphedema (AOR 2.65, 95% CI 1.71-4.10, p<0.001), tinea pedis (AOR 3.05, 95% CI 1.45-6.42, p=0.003) and saphenous vein harvest during coronary artery bypass grafting (AOR 1.74, 95% CI 1.32-2.30, p<0.001). Also associated with LLC was obesity (AOR 2.05, 95% CI 1.82-2.31, p<0.001), renal disease (AOR 1.28, 95% CI 1.14-1.44, p<0.001), rheumatologic conditions (AOR 2.12, 95% CI 1.72-2.60, p<0.001), hemiplegia/paraplegia (AOR 1.31, 95% CI 1.13-1.52, p<0.001) and liver disease (AOR 1.77, 95% CI 1.51-2.06, p<0.001). CONCLUSIONS: LLC presents a major burden to the health sector and is increasing with an ageing population. Given the high rates of recurrence, long-term morbidity and economic impact, efforts to reduce primary episodes should be incorporated into the infectious diseases and healthy ageing research agenda.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180210
[Lr] Last revision date:180210
[St] Status:Publisher

  6 / 1661 MEDLINE  
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[PMID]: 29417157
[Au] Autor:Buder V; Augustin M; Schäfer I; Welsch G; Catala-Lehnen P; Herberger K
[Ad] Address:Institut für Versorgungsforschung in der Dermatologie und bei Pflegeberufen (IVDP), Universitätsklinikum Hamburg-Eppendorf (UKE), Martinistr. 52, 20246, Hamburg, Deutschland. ivdp@uke.de.
[Ti] Title:Prävalenz von Dermatomykosen bei Profifußballspielern : Untersuchung im Rahmen der Bundesligatauglichkeitsuntersuchung (2013­2015) im Vergleich mit Daten der Allgemeinbevölkerung. [Prevalence of dermatomycoses in professional football players : A study based on data of German Bundesliga fitness check-ups (2013-2015) compared to data of the general population].
[So] Source:Hautarzt;, 2018 Feb 07.
[Is] ISSN:1432-1173
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:BACKGROUND: The prevention, early diagnosis and treatment of onychomycosis is of great importance for professional athletes to avoid physical limitations by complications. So far, there is only little data on the prevalence of dermatomycosis in professional athletes. OBJECTIVES: The aim of the study was to detect the prevalence of dermatomycosis in professional football players compared to the general population. MATERIALS AND METHODS: The prospective, non-interventional, controlled study on the prevalence of dermatomycosis in professional football players was carried out on football players of a German Bundesliga team compared with a previously studied, equivalently aged German working population. A questionnaire survey, a dermatological check-up and a microbiological detection of pathogens in cases of suspicion were performed. RESULTS: Data of 84 football players (n = 45 in 2013; n = 39 in 2015) were compared to data of n = 8186 male employees between 17 and 35 years of age. In the group of athletes, there were findings of 60.7% onychomycosis, 36.9% of tinea pedis and 17.8% of pityriasis versicolor. In the group of the age-equivalent general German working population the findings were: onychomycosis 3.3%, tinea pedis 3.2%, pityriasis versicolor 1.4%. CONCLUSION: Our study shows a clearly higher risk for fungal diseases of the skin especially on the feet of professional football players. The results show a necessity for elucidation within prevention and the establishment of an appropriate therapy of dermatomycosis for professional football players.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180208
[Lr] Last revision date:180208
[St] Status:Publisher
[do] DOI:10.1007/s00105-017-4120-3

  7 / 1661 MEDLINE  
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[PMID]: 29388537
[Au] Autor:Carreira A; Ferreira JB; Pereira I; Ferreira J; Filipe P; Ferreira RB; Monteiro S
[Ad] Address:1​CEV, SA, Parque Industrial de Cantanhede/Biocant-Park, lote 120, 3060-197 Cantanhede, Portugal.
[Ti] Title:Blad-containing oligomer: a novel fungicide used in crop protection as an alternative treatment for tinea pedis and tinea versicolor.
[So] Source:J Med Microbiol;67(2):198-207, 2018 Feb.
[Is] ISSN:1473-5644
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:PURPOSE: The lack of novel antifungal drugs and the increasing incidence and severity of fungal infections are major concerns worldwide. Herein, we tested the activity of the Blad-containing oligomer (BCO), a new antifungal molecule already in use for agriculture, on Malassezia spp. and dermatophytes, the causal agents of human tinea versicolor and tinea pedis. Given the lack of a standard method for Malassezia susceptibility testing and the plethora of published methods, we also developed an improved method for this genus. METHODOLOGY: The efficacy of BCO was assessed in vitro and compared to that of the drugs currently utilized in the treatment of tinea versicolor (fluconazole and itraconazole) and tinea pedis (itraconazole and terbinafine). For dermatophytes, the standard microdilution broth-based method was used, with small adjustments, and several broth formulations and inocula sizes were tested to develop an improved susceptibility method for Malassezia spp. RESULTS: We successfully developed a microdilution broth-based method with considerable advantages over other available methods, and used it for all in vitro susceptibility tests of Malassezia spp. isolates. We report that, on a molar basis, BCO was more effective than fluconazole or itraconazole on most strains of Malassezia spp. isolated from clinical samples (n=29). By contrast, BCO was less effective than itraconazole or terbinafine on the common dermatophytes Trichophyton rubrum and Trichophyton interdigitale. CONCLUSION: These data place BCO as a promising drug for the treatment of Malassezia-associated skin diseases. Further in vivo studies are now required to ascertain its applicability in the clinical setting.
[Mh] MeSH terms primary: Antifungal Agents/pharmacology
Arthrodermataceae/drug effects
Fungicides, Industrial/pharmacology
Malassezia/drug effects
Tinea Pedis/drug therapy
Tinea Versicolor/drug therapy
[Mh] MeSH terms secundary: Antifungal Agents/therapeutic use
Crop Protection
Drug Discovery
Fluconazole/pharmacology
Fungicides, Industrial/therapeutic use
Humans
Itraconazole/pharmacology
Microbial Sensitivity Tests
Tinea Pedis/microbiology
Tinea Versicolor/microbiology
Trichophyton/drug effects
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antifungal Agents); 0 (Fungicides, Industrial); 304NUG5GF4 (Itraconazole); 8VZV102JFY (Fluconazole)
[Em] Entry month:1802
[Cu] Class update date: 180206
[Lr] Last revision date:180206
[Js] Journal subset:IM
[Da] Date of entry for processing:180202
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000675

  8 / 1661 MEDLINE  
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[PMID]: 29323069
[Au] Autor:Sharma R; Adhikari L; Sharma RL
[Ad] Address:Department of Microbiology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India.
[Ti] Title:Recurrent dermatophytosis: A rising problem in Sikkim, a Himalayan state of India.
[So] Source:Indian J Pathol Microbiol;60(4):541-545, 2017 Oct-Dec.
[Is] ISSN:0974-5130
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Changing pattern of dermatophytic infection among people of Sikkim over the past few years and its recurrence rate has brought a need to do a study on clinical pattern and its recurrence from this part of the country. The objectives of this study are to discern the clinical patterns of dermatophytosis, identification of the isolated fungi to its species level and to see the pattern of its recurrence. The study was carried out from January 2015 to May 2016. A total of 192 samples were collected from the patients with clinical findings of dermatophytic infection. Required history of the patients was taken, followed by clinical examination of the lesions and sample collection. The samples were processed for mycological study till species identification and a follow up of patients were done to assess its recurrence pattern. The age distribution of the patients was from 2 to 80 years. The mean and median age was 30.33 and 33 years respectively. The male female ratio was 1.8:1. Dermatophytosis was noted more commonly in students (n = 64, 33.33%) and jawans (n = 44, 22.92%). Maximum occurrence was noted from April to July (n = 106, 55.20%) and was seen mainly in young Hindu males. Tinea corporis (n = 104, 54.16%) was the most common clinical manifestation followed by tinea unguium (n = 30, 15.63%). T. mentagrophyte (40%) was the most common species followed by T. schoenleinii (33.3%), T. tonsurans (16.6%) and T. rubrum (6.6%). The recurrence rate was seen most commonly in clinical cases of tinea faciei 100%, followed by tinea pedis 80% and tinea unguium 46.6%. Overall clinical cure rate was 58.3% and recurrence rate was 34.3%. In the isolated species of dermatophytes, the recurrence rate was 73.68% and that of non-dermatophytes it was 28.07%. Dermatophytosis is an important health problem with high recurrence in Sikkim with difference in the etiological agent from other parts of India.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180111
[Lr] Last revision date:180111
[St] Status:In-Process
[do] DOI:10.4103/IJPM.IJPM_831_16

  9 / 1661 MEDLINE  
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[PMID]: 29198783
[Au] Autor:Alter SJ; McDonald MB; Schloemer J; Simon R; Trevino J
[Ad] Address:Division of Infectious Diseases, Dayton Children's Hospital, One Children's Plaza, Dayton, OH; Department of Pediatrics, Wright State University, Boonshoft School of Medicine, Dayton, OH.
[Ti] Title:Common Child and Adolescent Cutaneous Infestations and Fungal Infections.
[So] Source:Curr Probl Pediatr Adolesc Health Care;48(1):3-25, 2018 Jan.
[Is] ISSN:1538-3199
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cutaneous infections and infestations are common among children and adolescents. Ectoparasitic infestations affect individuals across the globe. Head lice, body lice, scabies, and infestations with bed bugs are seen in individuals who reside in both resource poor areas and in developed countries. Superficial cutaneous and mucosal candida infections occur throughout the life cycle. Dermatophyte infections of keratin-containing skin and skin structures result in tinea capitis (scalp), tinea corporis (body), tinea pedis (foot), and tinea unguium (nails). Less frequent endemic fungal infections such as blastomycosis, coccidiodomycosis, and histoplasmosis may present with skin findings. This article will describe the epidemiology and transmission of these conditions as well as their clinical manifestations. The approach to diagnosis will be addressed as well as primary prevention and current therapies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171231
[Lr] Last revision date:171231
[St] Status:In-Data-Review

  10 / 1661 MEDLINE  
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[PMID]: 29136060
[Au] Autor:Rich P; Vlahovic TC; Joseph WS; Zane LT; Hall SB; Gellings Lowe N; Adigun CG
[Ad] Address:Oregon Dermatology and Research, Portland, USA.
[Ti] Title:Clinical trial designs for topical antifungal treatments of onychomycosis and implications on clinical practice.
[So] Source:Cutis;100(4):259-264, 2017 Oct.
[Is] ISSN:2326-6929
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:There currently are 3 topical agents approved by the US Food and Drug Administration (FDA) to treat onychomycosis: tavaborole, efinaconazole, and ciclopirox. The phase 3 clinical trial designs for these treatments and their notable differences make it difficult for clinicians to interpret the data into clinical practice. For example, the primary end point predominantly used to assess efficacy in all the trials is complete cure, defined as no involvement of the nail plus mycologic cure; also, a notable number of patients fail to achieve a complete cure despite clear improvement in the nail. Despite close similarities in the end points and overall design of the clinical trials used for these agents, differences in design are notable, including the age range of participants, the range of mycotic nail involvement, the presence/absence of tinea pedis, and the nail trimming/debridement protocols used. The differences in clinical trial designs for the 3 FDA-approved topical agents and the lack of head-to-head studies makes efficacy interpretation and comparison inappropriate. This article reviews the phase 3 clinical trials that led to FDA approval of these agents, focusing on their similarities and differences.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171114
[Lr] Last revision date:171114
[St] Status:In-Process


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