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[PMID]: 29524554
[Au] Autor:Chu HY; Chen X; Jiang YE; Wang W; Qi X; Zhong ZM; Zeng MS; Zhu XF; Sun CZ
[Ad] Address:Department of Head and Neck Surgery, The Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kunming, China; Department of Respiratory Medicine, Gaoyou People 's Hospital, 116 Fuqian Street, Gaoyou, China.
[Ti] Title:Bafilomycin A1 increases the sensitivity of tongue squamous cell carcinoma cells to cisplatin by inhibiting the lysosomal uptake of platinum ions but not autophagy.
[So] Source:Cancer Lett;, 2018 Mar 07.
[Is] ISSN:1872-7980
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:The role of autophagy in tongue squamous cell carcinoma (TSCC) cisplatin resistance is unclear. We aimed to identify a possible synergistic effect of autophagy inhibitors and cisplatin in TSCC cells and explore the underlying mechanism. Our results indicate that autophagic flux was high in TSCC cells; Autophagy inhibitor bafilomycin A1 increased cisplatin cytotoxicity in TSCC cells by inhibiting lysosomal uptake of platinum and enhancing intracellular platinum ion binding to DNA; Autophagy gene (Atg5) knockout in TSCC cells did not duplicate the above-mentioned sensitization of bafilomycin A1. Furthermore, we found that cisplatin resistance of TSCC cells was related to cisplatin inducing lysosome biogenesis in a TFEB-dependent manner, which was regulated by c-Abl. In summary, this is the first study to show that Bafilomycin A1 increases the sensitivity of TSCC cells to cisplatin by inhibiting lysosomal function but not autophagy. Lysosomes may be a potential target to increase cisplatin cytotoxicity toward TSCC cells.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 63516 MEDLINE  
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[PMID]: 29477742
[Au] Autor:Kobayashi-Sakamoto M; Tamai R; Isogai E; Kiyoura Y
[Ad] Address:Department of Oral Medical Science, Ohu University School of Dentistry, Koriyama, Fukushima, Japan. Electronic address: m-kobayashi@den.ohu-u.ac.jp.
[Ti] Title:Gastrointestinal colonisation and systemic spread of Candida albicans in mice treated with antibiotics and prednisolone.
[So] Source:Microb Pathog;117:191-199, 2018 Feb 22.
[Is] ISSN:1096-1208
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Normally, Candida albicans is a commensal microbe that resides in the human oral cavity, gut and vagina. However, the fungus can cause mucosal and systemic infections in immunocompromised individuals. The mechanism by which local mucosal infections progress to systemic candidiasis is poorly understood. Here, a murine model of gastrointestinal (GI) candidiasis was developed by inoculation of the oral cavity, followed by treatment with tetracycline (TC) and prednisolone (PSL). Temporal progression from a local infection of the oral cavity to a systemic infection was then monitored. Histological analysis of tissues from mice treated with both TC and PSL revealed massive infiltration of the tongue and stomach by hyphae. PSL increased the fungal burden in the tongue, stomach and small intestine, and facilitated dissemination to the spleen, kidney and liver within 3 days post-infection. Treatment with both TC and PSL supressed interferon (IFN)-γ and interleukin (IL)-17 (cytokines that play key roles in host defence against fungal infection) levels in the tongue, which were induced by C. albicans infection. In addition, the mucosal layer of the small intestine of mice treated with both TC and PSL was almost destroyed by the fungal infection; this may be a critical event that allows passage of the fungus across the mucosa and into the systemic circulation. Thus, this mouse model is useful for studying mechanisms underlying progression of C. albicans from a local infection of the oral cavity to a systemic infection in immunocompromised individuals.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 63516 MEDLINE  
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[PMID]: 29353095
[Au] Autor:Park SH; Casamento-Moran A; Singer ML; Ernster AE; Yacoubi B; Humbert IA; Christou EA
[Ad] Address:Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
[Ti] Title:Integration of visual feedback and motor learning: Corticospinal vs. corticobulbar pathway.
[So] Source:Hum Mov Sci;58:88-96, 2018 Jan 30.
[Is] ISSN:1872-7646
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Although movement is controlled by different descending pathways, it remains unknown whether the integration of visual feedback and motor learning differs for movements controlled by different descending pathways. Here, we compare motor control and learning of the ankle joint and tongue because they are primarily controlled by the corticospinal and corticobulbar pathways, respectively. Twelve young adults (19.63 ±â€¯2.11 years, 6 females) practiced a tracking task (combination of 0.02, 0.37, 0.5, and 1 Hz) with ankle dorsiflexion and with tongue elevation for 100 trials. The participants practiced each effector (ankle and tongue) in different days and the order of the effector was counterbalanced. Following practice, participants performed the same tracking task with concurrent contractions of the tongue and ankle (dual tracking task; transfer) with three different visual feedback conditions (no visual feedback, visual feedback only for ankle, visual feedback only for tongue). We quantified the force accuracy (RMSE) from each effector during the practice and transfer periods. During practice, the force accuracy and performance improvement to the visuomotor task was greater for the ankle dorsiflexion than tongue elevation. During the transfer task, the ankle dorsiflexion was more accurate than tongue elevation, independent of whether visual feedback was given for the ankle or tongue. The greater performance improvement for the ankle dorsiflexion during practice was related to superior transfer performance. These findings suggest that the corticospinal pathway integrates visual feedback more efficiently than the corticobulbar pathway, which enhances performance and learning of visuomotor tasks.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  4 / 63516 MEDLINE  
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[PMID]: 29311490
[Au] Autor:Hsu CD; Mathura Y
[Ad] Address:Department of Veterinary Services, Wildlife Reserves Singapore, 80 Mandai Lake Road Singapore 729826, Singapore.
[Ti] Title:Severe visceral pentastomiasis in an oriental small-clawed otter with functional thyroid carcinoma.
[So] Source:J Vet Med Sci;80(2):320-322, 2018 Feb 20.
[Is] ISSN:1347-7439
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:In January 2016, a 20-year-old female oriental small-clawed otter (Aonyx cinereus) from Night Safari in Singapore was euthanized and diagnosed with a thyroid gland carcinoma. Postmortem examination and histology also revealed metastasis to the regional lymph nodes and severe visceral pentastomiasis. Grossly, the lymph nodes were infested, and encapsulation was observed on the visceral serosal surface. Histopathologically, the lymph nodes were encysted by a thick fibrous connective capsule with minimal inflammatory response. Pentastomiasis has been previously reported in the smooth-coated otter (Lutrogale perspicillata) in Malaysia. This report is the first case of severe visceral pentastomiasis in an oriental small-clawed otter with functional thyroid carcinoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.1292/jvms.17-0383

  5 / 63516 MEDLINE  
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[PMID]: 29269709
[Au] Autor:Hirata A; Kasahara M; Matsuura N; Ichinohe T
[Ad] Address:Department of Dental Anesthesiology, Tokyo Dental College, Tokyo 101-0061, Japan.
[Ti] Title:Remifentanil decreases oral tissue blood flow while maintaining internal carotid artery blood flow during sevoflurane anesthesia in rabbits.
[So] Source:J Vet Med Sci;80(2):354-360, 2018 Mar 02.
[Is] ISSN:1347-7439
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:The aim of this study was to investigate the effect of remifentanil infusion on oral tissue blood flow including submandibular gland tissue blood flow (SBF) and internal carotid artery blood flow (ICBF) in rabbits during sevoflurane anesthesia. Twelve male Japan White rabbits were anesthetized with sevoflurane and remifentanil. Remifentanil was infused at 0.2 and 0.4 µg/kg/min. Measurements included circulatory variables, common and external carotid artery blood flow (CCBF, ECBF), ICBF, tongue mucosal blood flow (TMBF), masseter muscle tissue blood flow (MBF), mandibular bone marrow tissue blood flow (BBF), tongue muscle tissue blood flow (TBF) and SBF. Vascular resistances for each tissue, including the tongue mucosa, masseter muscle, mandibular bone marrow, tongue muscle and submandibular gland, were calculated by dividing the mean arterial pressure by the respective tissue blood flow. Remifentanil infusion decreased oral tissue blood flow and circulatory variables. CCBF, ECBF and ICBF did not change. The calculated vascular resistance in each oral tissue, except for the tongue mucosa, increased in an infusion-rate-dependent manner. These results showed that remifentanil infusion reduced TMBF, MBF, BBF, TBF and SBF in an infusion-rate-dependent manner without affecting ICBF under sevoflurane anesthesia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[St] Status:In-Process
[do] DOI:10.1292/jvms.17-0319

  6 / 63516 MEDLINE  
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[PMID]: 29523225
[Au] Autor:Kou N; Liu S; Li X; Li W; Zhong W; Gui L; Chai S; Ren X; Na R; Zeng T; Liu H
[Ad] Address:College of Stomatology, Dalian Medical University, Dalian, Liaoning, China.
[Ti] Title:H19 facilitates tongue squamous cell carcinoma migration and invasion via sponging miR-let-7.
[So] Source:Oncol Res;, 2018 Mar 09.
[Is] ISSN:1555-3906
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The long noncoding RNA (lncRNA) H19 has been described to participate in various tumors metastasis. Nevertheless, whether H19 promotes or impedestongue squamous cell carcinoma (TSCC) cells migration and invasion remains controversial. Here, we found that the expression of H19 was elevated in TSCC tissues compared with adjacent normal tissues. Moreover, we demonstrated that the expression of H19 was higher in metastasized tumors compared with un-metastasized tumors. Consistently, TSCC cells express higher levels of H19 than human squanous cells. Subsequently, depletion of H19 impaired the migration and invasion ability of TSCC cells. Mechanisticlly, we demonstrated that H19 functions as a competing endogenous RNA (ceRNA) to sponge miRNA let-7a, leading to an increase in a let-7a target, the key regulator of tumor metastasis HMGA2, which is enriched in TSCC tissues and cell lines. Intriguingly, inhibition of let-7a significantly rescued short hairpin H19 (shH19) induced decrease of TSCC migration and invasion. These findings revealed that H19/let-7a/HMGA2/EMT axis plays a critical role in the regulation of TSCC migration and invasion, which may provide a new therapeutic target for TSCC cancers.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.3727/096504018X15202945197589

  7 / 63516 MEDLINE  
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[PMID]: 29522797
[Au] Autor:Yano J; Aoyagi Y; Ono T; Hori K; Yamaguchi W; Fujiwara S; Kumakura I
[Ad] Address:Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama 701-0193, Japan. Electronic address: yano@mw.kawasaki-m.ac.jp.
[Ti] Title:Effect of bolus volume and flow time on temporospatial coordination in oropharyngeal pressure production in healthy subjects.
[So] Source:Physiol Behav;, 2018 Mar 06.
[Is] ISSN:1873-507X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The effects of bolus volume and flow time on the sequential coordination of tongue pressure (TP) and pharyngeal pressure (PP), which are important in the biomechanics of swallowing, are unclear. In this study, we measured TP and PP simultaneously in 10 healthy adults at multiple points during dry swallowing and the swallowing of 5 ml and 15 ml of liquids with different viscosities, and investigated changes in the timing of the onset, peak, and offset of these pressures. TP was measured using a sensor sheet system with five measuring points on the hard palate, and PP was measured using a manometry catheter with four measuring points. The order and correlations of sequential events, such as onset, peak, and offset times of pressure production, at each pressure measuring point were analyzed on the synchronized waveforms. We found that the differences between the TP and PP onset times decreased when the bolus volume was larger. The change in bolus volume had (very) little effect on peak time or offset time. The flow time of the bolus affected the appearance of onset and peak time for both TP and PP. A time difference between TP and PP emerged as the flow time increased, with TP starting to appear before PP. This may be the first detailed analysis of pressure-flow dynamics that treats the mouth and pharynx as a single functional unit. We believe that our analysis is an important step toward extending future research to include a wider range of age groups and dysphagia patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  8 / 63516 MEDLINE  
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[PMID]: 29473197
[Au] Autor:Kang JH; Sung J; Song YM; Kim YH
[Ad] Address:Clinic of Oral Medicine and Orofacial Pain, Institute of Oral Health Science, Ajou University School of Medicine, Suwon, Korea.
[Ti] Title:Heritability of the airway structure and head posture using twin study.
[So] Source:J Oral Rehabil;, 2018 Feb 23.
[Is] ISSN:1365-2842
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Inherited traits of obstructive sleep apnoea (OSA) may have link to the heritability of the airway anatomy. The aim of this study was to investigate heritability of the airway anatomy by comparing skeletal and soft tissue features of Korean monozygotic twins (MZ) and dizygotic twins (DZ). In total, 72 participants (mean age, 41.5 ± 5.9 years; 40 males, 32 females) including 48 MZ (24 pairs) and 24 DZ (12 pairs) with same sex were participated. The craniofacial, craniovertebral, hyoideal and pharyngeal parameters were measured using lateral cephalograms. The genetic analysis was performed using Falconer's method. High heritability was detected in the hyoid position and inclination of the cervical column. The velopharyngeal and hypopharyngeal dimensions showed higher heritability compared to those of the nasopharynx and oropharynx. The body mass index (BMI) had interactions with the nasopharyngeal and hypopharyngeal dimensions and length of the tongue and soft palate. The mandibular growth had correlations with the nasopharyngeal and hypopharyngeal dimensions. The vertical skeletal relationships appeared to have interaction with the nasopharyngeal, velopharyngeal and hypopharyngeal dimensions, as well as length of the tongue and soft palate. A forwarded inclination of the cervical columns was seen in connections with BMI and the nasopharyngeal and hypopharyngeal dimensions. The airway structures and head postures seemed to be under strong genetic controls. The airway dimensions had associations with BMI, head postures and skeletal structures which showed high heritability. Forwarded head postures would be physiological adaptations of compromised airway adequacy by increased BMI and retrognathia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1111/joor.12620

  9 / 63516 MEDLINE  
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[PMID]: 29466834
[Au] Autor:Castiglione MP; Ramos RL; Leheste JR; Torres G
[Ad] Address:Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, New York, 11568.
[Ti] Title:Central and Peripheral Expression of DNA Double-Strand Breaks in Human and Mouse Tissues.
[So] Source:Anat Rec (Hoboken);, 2018 Feb 21.
[Is] ISSN:1932-8494
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Mammalian cells accumulate DNA lesions when they undergo phases of the cell cycle or during normal cellular activity. In this regard, several DNA repair signaling pathways have evolved to maintain genome stability and avoid the potential acquisition of mutations. To define and further characterize the expression of DNA double-strand breaks in humans and mice, we used immunocytochemistry to localize a DNA damage signal within the spatial confines of the cell nucleus. We show that DNA double-strand breaks are abundantly expressed in postmitotic neurons of the human and mouse brain. Notably, DNA double-strand breaks are present in human hypothalamic and mouse striatal and hippocampal cells, with stable expression of the nuclear signal detected throughout the mammalian brain. Analysis of the mouse tongue, heart, and testis shows that expression of DNA double-strand breaks is only demonstrated in circumscribed populations of peripheral cells. These data suggest that levels of DNA double-strand breaks are tissue-specific with the tongue, heart and testicular tissue having different thresholds of DNA repair and DNA damage from those outlined at the brain level. Anat Rec, 2018. © 2018 Wiley Periodicals, Inc.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1002/ar.23799

  10 / 63516 MEDLINE  
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[PMID]: 29431926
[Au] Autor:Kalaev VN; Nechaeva MS
[Ti] Title:[The study of the frequency of buccal epithelium cells with nuclear in athletes in dependence on the place got in the competition].
[So] Source:Gig Sanit;95(10):992-7, 2016.
[Is] ISSN:0016-9900
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Cytogenetic homeostasis ofathletes involved in hand-to-hand armyfighting, depending on the outcome of the fight and the level of aggressiveness has been studied. Status of the genetic apparatus in athletes was evaluated in buccal epithelium with the use of micronucleus test, which is widely usedfor the determination of the influence of various factors on the genetic stability of the organism. Psychological testing of athletes was executed with the use of Spielberger's State-Trait Anger Expression Inventory scale, Bass-Darky questionnaire for the diagnostics of aggression and hostile reactions, Eysenck Personality Questionnaire test for the evaluation ofpsychic conditions and method of U.P. Ilyin and P.A. Kovalev for the identification of the propensity to conflictness and aggressiveness (positive and negative) as the personal characteristics. The place taken by the athlete on the competition was shown to have an impact on the frequency of buccal epithelium cells with nuclear abnormalities (micronuclei, perinuclear vacuoles, notches, protrusions "tongue" and "broken egg"). Losers have nuclear aberrations more than winners. At that in athletes with higher aggressiveness and its attendant psychological characteristics the influence of the outcome of the competition on the number of cells with aberrations core is more pronounced.
[Mh] MeSH terms primary: Aggression
Athletic Performance
Martial Arts
Micronucleus Tests/methods
Mouth Mucosa/pathology
[Mh] MeSH terms secundary: Adolescent
Aggression/physiology
Aggression/psychology
Athletes/psychology
Athletic Performance/physiology
Athletic Performance/psychology
Cytogenetic Analysis/methods
Humans
Male
Martial Arts/physiology
Martial Arts/psychology
Psychological Tests
Statistics as Topic
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180213
[St] Status:MEDLINE


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