Database : MEDLINE
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[PMID]: 29523605
[Au] Autor:Talbot A; Lippiatt C; Tantry A
[Ad] Address:Department of Paediatrics, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
[Ti] Title:Lead in a case of encephalopathy.
[So] Source:BMJ Case Rep;2018, 2018 Mar 09.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A 2-year-old boy with a history of pica was admitted with vomiting and treated overnight for viral tonsillitis. A week later, he presented with a prolonged afebrile seizure and required intubation and ventilation. Antibiotics and acyclovir were started. Despite extensive investigations including MRI head, no cause was identified. Four days later, he deteriorated with signs of raised intracranial pressure. On day 5, blood lead concentration in the sample collected at admission was reported as grossly elevated, consistent with a diagnosis of severe lead poisoning from ingesting lead-containing paint at the family home. Chelation therapy was started but, unfortunately, he did not make a neurological recovery, and care was withdrawn. A serious case review identified a lack of awareness of lead poisoning and its relation to pica as a root cause. We report this case to share our experience and the importance of considering lead poisoning in children with pica.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Process

  2 / 7488 MEDLINE  
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[PMID]: 29505705
[Au] Autor:Banigo A; Moinie A; Bleach N; Chand M; Chalker V; Lamagni T
[Ad] Address:ENT Department Heatherwood and Wexham Park Hospitals NHS Trust.
[Ti] Title:Have reducing tonsillectomy rates in England led to increasing incidence of invasive Group A Streptococcus infections in children?
[So] Source:Clin Otolaryngol;, 2018 Mar 05.
[Is] ISSN:1749-4486
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To determine if there is a correlation between falling tonsillectomy numbers and increasing numbers of tonsillitis admissions and invasive Group A ß-haemolytic streptococcus (iGAS) infection in children aged 14 and under in England. DESIGN: An observational cross-sectional study was performed. SETTING: The data extracted covered the period from 1991 until 2014. PARTICIPANTS: Hospital admissions for tonsillectomies, tonsillitis/pharyngitis, and and all diagnoses of iGAS in children aged 14 and under who had a tonsillectomy. MAIN OUTCOME MEASURES: Correlation between trends in tonsillectomies, tonsillitis/pharyngitis and iGAS. RESULTS: Across all age groups there was a dramatic reduction in the total number of tonsillectomies performed in England from 28,309 in 1990/1991, down to 6327 in 2013/2014 (77.7% reduction). The numbers of hospital admissions for management of acute tonsillitis and pharyngitis has risen dramatically. iGAS numbers have increased steadily over this time period and more than doubled in children aged 14 and under. There are significant negative correlations between the trend in iGAS infections and numbers of tonsillectomies in all ages. There are also strong positive correlations between the trend in numbers of tonsillitis episodes and the number of iGAS infections in all under14 year groups; the strongest correlation was seen in the 1-4 years age group (+0.92 Pearson correlation coefficient). CONCLUSIONS: There appears to be a correlation between falling tonsillectomy numbers, increasing hospital admissions with tonsillitis and rising iGAS infection in England. Further studies are required to assess the aetiological role of tonsillitis in predisposing to iGAS infection and the potential societal benefit of tonsillectomies. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1111/coa.13095

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[PMID]: 29504815
[Au] Autor:Jin L; Li K; Li X
[Ad] Address:a Department of Otolaryngology, Head and Neck Surgery , Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
[Ti] Title:Distortion product otoacoustic emission together with tympanometry for assessing otitis media with effusion in children.
[So] Source:Acta Otolaryngol;:1-4, 2018 Mar 05.
[Is] ISSN:1651-2251
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To investigate the diagnostic value of distortion product otoacoustic emission (DPOAE) together with tympanometry in assessing otitis media with effusion in children. METHODS: Three hundred and thirty-nine patients, who were diagnosed with obstructive sleep apnea-hypopnea syndrome (OSAHS) and prepared to undergo adenotonsillectomy and had a unilateral or bilateral type 'B' or 'C' tympanogram were enrolled in this study. Patients were divided into the following four groups: Group 1, type 'B' tympanogram with positive DPOAE; Group 2, type 'B' tympanogram with negative DPOAE; Group 3, type 'C' tympanogram with positive DPOAE and Group 4, type 'C' tympanogram with negative DPOAE. RESULTS: Tympanometry showed a type 'B' pattern in 467 ears and type 'C' pattern in 163 ears. Among 163 ears with type 'C' tympanogram, negative DPOAE results were seen in 96 ears. Group 4 (56/96) had a significant high rate of middle ear effusion than Group 3 (14/67) (p < .05). In patients with a type 'C' tympanogram, those with a low compliance value (∼0.25 ml), concurrent chronic tonsillitis and large tonsils are likely to have middle ear effusion. CONCLUSIONS: DPOAE could be a great help in screening for middle ear effusion in patients with a type 'C' tympanogram.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1080/00016489.2018.1439591

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[PMID]: 29502129
[Au] Autor:Komeno Y; Ota Y; Koibuchi T; Imai Y; Iihara K; Ryu T
[Ad] Address:Department of Hematology, Japan Community Healthcare Organization (JCHO), Tokyo Yamate Medical Center, Tokyo, Japan.
[Ti] Title:Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma.
[So] Source:Am J Case Rep;19:238-243, 2018 Mar 04.
[Is] ISSN:1941-5923
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND Syphilis is a sexually transmitted disease caused by the pathogen Treponema pallidum. Prevalence continues to rise, especially among men who have sex with men (MSM). Due to changes in patterns of sexual activity, manifestations of the disease are highly variable. CASE REPORT A 27-year-old male visited the hospital for a low-grade fever and tender 5-cm mass in the right side of his neck. His right tonsil was swollen and covered with a white coating. Levofloxacin was prescribed, but ineffective. The patient's levels of liver function enzymes increased gradually. Systemic magnetic resonance imaging (MRI) revealed bilateral cervical lymphadenopathy with right predominance, a right pulmonary nodule, and a periportal lymph node, suggestive of malignant lymphoma. However, a biopsy of the right cervical lymph node showed nonspecific inflammation. Preoperative rapid plasma reagin (RPR) and T. pallidum latex agglutination (TPLA) tests were positive. The patient was MSM and reported oral sex with many sexual partners. A diagnosis of secondary syphilis was made. Oral amoxicillin was effective, and all symptoms other than periportal lymph node resolved. CONCLUSIONS Tonsillitis, cervical lymphadenopathy, and lung lesions can be manifestations of secondary syphilis. A detailed history, pathology, and serology are crucial for diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Process

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[PMID]: 29501312
[Au] Autor:Sánchez-Rodríguez C; Peraza Cruces KR; Rodrigáñez Riesco L; García-Vela JA; Sanz-Fernández R
[Ad] Address:European University of Madrid, Calle del Tajo S/N 28670 Villaviciosa de Odón, Madrid, Spain. Electronic address: carolina.sanchez2@universidadeuropea.es.
[Ti] Title:Immunomodulatory effect of Polypodium leucotomos (Anapsos) in child palatine tonsil model.
[So] Source:Int J Pediatr Otorhinolaryngol;107:56-61, 2018 Apr.
[Is] ISSN:1872-8464
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:BACKGROUND: Recurrent tonsillitis might reduce the immunological capability of fighting against the infection of tonsil tissue. Polypodium leucotomos (Anapsos) immunomodulating effect has been subject of research in the last years. The aim of this research is to test the in vitro immunomodulating capacity of Anapsos in a child palatine tonsil explants model. METHODS: Palatine tonsils explants of children undergoing amigdalectomy were stimulated with mononuclear cells obtained from their own blood by density gradient centrifugation. Some were then treated with Anapsos while others rest untreated. Cytokines were measured by ELISA, immune cells activation was measured by flow cytometry and activation of immunoglobulins was appreciated by indirect immunofluorescence in tonsils tissue. RESULTS: Anapsos activates Natural Killers cells. It increases IL-2 and IFN-γ levels by the activation of Th2 lymphocytes, and IL-10, by the Th1 lymphocytes. Anapsos also increases immunoglobulins IgM, IgD and IgG4 by B-lymphocyte activation in tonsils tissue. CONCLUSION: Anapsos has an immunomodulating effect, both in humoral and cellular responses, which might benefit children suffering of recurrent tonsillitis as it could enhance their immune system. This effect might reduce the number of episodes suffered and therefore the number of children undergoing surgery.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Process

  6 / 7488 MEDLINE  
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[PMID]: 29367531
[Au] Autor:Azuma K; Tamura M; Makino H; Sekiguchi M; Azuma N; Kitano M; Matsui K; Sano H
[Ad] Address:Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine.
[Ti] Title:[A case of axial spondyloarthritis acute onset as opportunity tonsil foci infection].
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;40(6):460-466, 2017.
[Is] ISSN:1349-7413
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:  A 49-year-old female with a chief complaints of arthralgia, and a medical history is Hashimoto's disease presented to us. She had been previously treated for Sjögren's syndrome at our hospital. She had anterior chest and polyarticular pain. On admission, her blood test results were as follows: white blood cells, 12700/µl; C reactive protein, 24.8 mg/dl; erythrocyte sedimentation rate 122 mm/h, Anti-streptolysin O, 1179 IU/ml;an, ASK, 10240. She had tenderness in both her hand and finger joints, recurrent episodes of tonsillitis and pustular eruption. Her imaging studies were remarkable for inflammation of the sacroiliac joint and bone erosion of the hand joint, among other findings. We considered a diagnosis of either axial spondyloarthritis or synovitis acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome due to an opportunistic tonsillar infection. The differential diagnosis between axial spondyloarthritis or SAPHO syndrome is difficult to make. We discuss this case in the context of previous literature.
[Mh] MeSH terms primary: Opportunistic Infections/complications
Spondylarthritis/complications
Spondylarthritis/diagnosis
Tonsillitis/complications
[Mh] MeSH terms secundary: Acquired Hyperostosis Syndrome
Acute Disease
Diagnosis, Differential
Female
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180227
[Lr] Last revision date:180227
[Js] Journal subset:IM
[Da] Date of entry for processing:180126
[St] Status:MEDLINE
[do] DOI:10.2177/jsci.40.460

  7 / 7488 MEDLINE  
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[PMID]: 29260375
[Au] Autor:Al-Mahtot M; Barwise-Munro R; Wilson P; Turner S
[Ad] Address:Child Health, Royal Aberdeen Children's Hospital, Aberdeen, AB25 2ZG, UK.
[Ti] Title:Changing characteristics of hospital admissions but not the children admitted-a whole population study between 2000 and 2013.
[So] Source:Eur J Pediatr;177(3):381-388, 2018 Mar.
[Is] ISSN:1432-1076
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:There are increasing numbers of emergency medical paediatric admissions. Our hypothesis was that characteristics of children and details of their emergency admissions are also changing over time. Details of emergency admissions in Scotland 2000-2013 were analysed. There were 574,403 emergency admissions, median age 2.3 years. The age distribution, proportion of boys and socioeconomic status of children admitted were essentially unchanged. Emergency admissions rose by 49% from 36/1000 children per annum to 54/1000 between 2000 and 2013. Emergency admissions that were discharged on the same day rose by 186% from 8.6/1000 to 24.6/1000. The mean duration of emergency admission fell from 1.7 to 1.0 days. The odds for an emergency admission with upper respiratory infection, "viral infection", tonsillitis, bronchiolitis and lower respiratory tract infection all rose. In contrast the odds for an emergency admission with asthma and gastroenteritis fell. CONCLUSIONS: The demographics of children with emergency admissions have not changed substantially but characteristics of admissions have changed considerably, in particular admissions which are short stay and due to respiratory infection are much more common. The fall in the absolute number of children with some acute medical diagnoses suggests that the rise in admissions is not necessarily inexorable. What is Known: • Emergency admission prevalence is rising in many countries across Europe. What is New: • Our paper is the first to comprehensively analyse emergency medical paediatric admissions by exploring how characteristics of admissions and the children admitted have changed over time for a whole population. • The "take home message" is that whilst characteristics of emergency admissions have changed (e.g. number, duration of stay, readmissions, diagnoses), the characteristics of the children have not changed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180228
[Lr] Last revision date:180228
[St] Status:In-Process
[do] DOI:10.1007/s00431-017-3064-z

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[PMID]: 29447978
[Au] Autor:Czerwinska ME; Dudek MK; Pawlowska KA; Prus A; Ziaja M; Granica S
[Ad] Address:Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland.
[Ti] Title:The influence of procyanidins isolated from small-leaved lime flowers (Tilia cordata Mill.) on human neutrophils.
[So] Source:Fitoterapia;, 2018 Feb 12.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Linden flower is a wildly used plant material among patients in the treatment of common cold symptoms and mucosa inflammations. However, the structure and bioactivity of flavan-3-ol derivatives present in infusions from flowers of Tilia cordata have not been studied so far. The aim of current study was to isolate and identify main procyanidins present in the flowers of small-leaved lime and to evaluate their influence on the inflammatory response of human neutrophils ex vivo. The chemical structure of isolated compounds was established by 1D and 2D NMR experiments. The bioactivity of obtained compounds was tested in human neutrophils model. Cytotoxicity and influence of compounds on apoptosis was established by flow cytometry. The levels of produced cytokines were established by ELISA after stimulation with lipopolysaccharide (LPS). The inhibition of the production of reactive oxygen species was checked by luminol-dependent chemiluminescence method after N-formylmethionyl-leucyl-phenylalanine (f-MLP) induction. The phytochemical work resulted in the isolation of 10 compounds. Compounds were identified as oligomeric procyanidins and their precursor epicatechin. The potential anti-inflammatory activity of compounds was evaluated in the concentration range 5-20 µM. All compounds were able to decrease the production of ROS from f-MLP-stimulated neutrophils. Most of compounds were able to inhibit the LPS-induced release of IL-8. Some trimeric and tetrameric derivatives were also able to decrease the production of MIP-1ß. Obtained results partially support the traditional usage of infusion from lime flowers in the treatment of symptoms of inflammation and irritation of mucosa in common cold, pharyngitis and tonsillitis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180225
[Lr] Last revision date:180225
[St] Status:Publisher

  9 / 7488 MEDLINE  
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[PMID]: 29453484
[Au] Autor:Vinod KS; Gupta N; Sahu H; Wig N
[Ad] Address:Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
[Ti] Title:Late Presentation of Post Diphtheritic Myocarditis in a 15-year Male.
[So] Source:JNMA J Nepal Med Assoc;56(208):475-477, 2017 Oct-Dec.
[Is] ISSN:0028-2715
[Cp] Country of publication:Nepal
[La] Language:eng
[Ab] Abstract:A 15-year old male patient presented to us with dyspnoea for four days. He had a history of fever, pseudo-membranous tonsillitis and cervical adenopathy twenty-five days prior to the presentation. On examination and laboratory investigations, he had features suggestive of myocarditis with biventricular failure. There was no reliable history of immunisation and he had a positive history of contact. He was planned for anti-diphtheria toxin but before the anti-toxin could be initiated, the patient succumbed to refractory cardiogenic shock. This was a rare case of late onset diphtheritic myocarditis in an unimmunised adult. With the advent of universal immunisation, there has been a significant decline in the incidence but there is still some road to cover.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180217
[Lr] Last revision date:180217
[St] Status:In-Data-Review

  10 / 7488 MEDLINE  
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[PMID]: 29453208
[Au] Autor:Liu T; Lingam R; Lycett K; Mensah FK; Muller J; Hiscock H; Huque MH; Wake M
[Ad] Address:Murdoch Children's Research Institute, Parkville, Victoria, Australia.
[Ti] Title:Parent-reported prevalence and persistence of 19 common child health conditions.
[So] Source:Arch Dis Child;, 2018 Feb 16.
[Is] ISSN:1468-2044
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To estimate prevalence and persistence of 19 common paediatric conditions from infancy to 14-15 years. DESIGN: Population-based prospective cohort study. SETTING: Australia. PARTICIPANTS: Parallel cohorts assessed biennially from 2004 to 2014 from ages 0-1 and 4-5 years to 10-11 and 14-15 years, respectively, in the Longitudinal Study of Australian Children. MAIN OUTCOME MEASURES: 19 health conditions: 17 parent-reported, 2 (overweight/obesity, obesity) directly assessed. Two general measures: health status, special health care needs. ANALYSIS: (1) prevalence estimated in 2-year age-bands and (2) persistence rates calculated at each subsequent time point for each condition among affected children. RESULTS: 10 090 children participated in Wave 1 and 6717 in all waves. From age 2, more than 60% of children were experiencing at least one health condition at any age. Distinct prevalence patterns by age-bands comprised eight conditions that steadily rose (overweight/obesity, obesity, injury, anxiety/depression, frequent headaches, abdominal pain, autism spectrum disorder, attention-deficit hyperactivity disorder). Six conditions fell with age (eczema, sleep problems, day-wetting, soiling, constipation, recurrent tonsillitis), three remained stable (asthma, diabetes, epilepsy) and two peaked in mid-childhood (dental decay, recurrent ear infections). Conditions were more likely to persist if present for 2 years; persistence was especially high for obesity beyond 6-7 (91.3%-95.1% persisting at 14-15). CONCLUSIONS: Beyond infancy, most Australian children are experiencing at least one ongoing health condition at any given time. This study's age-specific estimates of prevalence and persistence should assist families and clinicians to plan care. Conditions showing little resolution (obesity, asthma, attention-deficit hyperactivity disorder) require long-term planning and management.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180217
[Lr] Last revision date:180217
[St] Status:Publisher


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