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[PMID]: 29524350
[Au] Autor:Mohn CE; Troncoso GR; Bozzini C; Conti MI; Fernandez Solari JJ; Elverdin JC
[Ad] Address:Department of Physiology, School of Dentistry, University of Buenos Aires, Argentina.
[Ti] Title:Changes in PGE2 signaling after submandibulectomy alter post tooth extraction socket healing.
[So] Source:Wound Repair Regen;, 2018 Mar 10.
[Is] ISSN:1524-475X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Saliva is very important to oral health, and a salivary deficit has been shown to bring serious problems to oral health. There is scant information about the mechanisms through which salivary glands participate in post-tooth extraction socket healing. Therefore, the aim of the present study was to investigate the effect of submandibulectomy (SMx), consisting of the ablation of submandibular and sublingual glands (SMG and SLG, respectively), on PGE signaling and other bone regulatory molecules, such as OPG and RANKL, involved in tooth extraction socket healing. Male Wistar rats, 70g body weight, were assigned to an experimental (subjected to SMx) or a control group (sham operated). One week later, the animals in both groups underwent bilateral extraction of the first mandibular molars. The effect of SMx on different stages of socket healing after tooth extraction (7, 14 and 30 days) was studied by evaluating some parameters of inflammation, including PGE and its receptors, and of bone metabolism, as well as by performing bone biomechanical studies. SMx increased TNFα and PGE content as well as COX-II expression in tooth socket tissue at almost all the studied time-points. SMx also had an effect on mRNA expression of PGE receptors at the different time points, but did not significantly alter osteoprotegerin (OPG) and RANKL mRNA expression at any of the studied time points. In addition, an increase in bone mass density was observed in SMx rats compared to matched controls, and the structural and mechanical bone properties of the mandibular socket bone were also affected by SMx. Our results suggest that the SMG/SLG complex regulates cellular activation and differentiation by modulating the production of molecules intervening in tooth extraction socket repair, including the PGE signaling system, which would therefore account for the higher density and resistance of the newly formed bone in SMx rat. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher
[do] DOI:10.1111/wrr.12625

  2 / 22123 MEDLINE  
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[PMID]: 29523381
[Au] Autor:Klazen Y; Van der Cruyssen F; Vranckx M; Van Vlierberghe M; Politis C; Renton T; Jacobs R
[Ad] Address:OMFS-IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven, Leuven, Belgium; Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.
[Ti] Title:Iatrogenic trigeminal post-traumatic neuropathy: a retrospective two-year cohort study.
[So] Source:Int J Oral Maxillofac Surg;, 2018 Mar 06.
[Is] ISSN:1399-0020
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:With the growing demand for dental work, trigeminal nerve injuries are increasingly common. This retrospective cohort study examined 53 cases of iatrogenic trigeminal nerve injury seen at the Department of Oral and Maxillofacial Surgery, University Hospitals of Leuven between 2013 and 2014 (0.6% among 8845 new patient visits). Patient records were screened for post-traumatic trigeminal nerve neuropathy caused by nerve injury incurred during implant surgery, endodontic treatment, local anaesthesia, tooth extraction, or specifically third molar removal. The patients ranged in age from 15 to 80years (mean age 42.1years) and 68% were female. The referral delay ranged from 1day to 6.5years (average 10months). The inferior alveolar nerve (IAN) was most frequently injured (28 cases), followed by the lingual nerve (LN) (21 cases). Most nerve injuries were caused during third molar removal (24 cases), followed by implant placement (nine cases) and local anaesthesia injuries (nine cases). Pain symptoms were experienced by 54% of patients suffering IAN injury, compared to 10% of patients with LN injury. Persistent neurosensory disturbances were identified in 60% of patients. While prevention remains the key issue, timely referral seems to be a critical factor for the successful treatment of post-traumatic neuropathy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  3 / 22123 MEDLINE  
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[PMID]: 29520950
[Au] Autor:Wong RL; Hiyari S; Yaghsezian A; Davar M; Casarin M; Lin YL; Tetradis S; Camargo PM; Pirih FQ
[Ad] Address:University of California, Los Angeles, Section of Periodontics, Los Angeles, California.
[Ti] Title:Early intervention of peri-implantitis and periodontitis utilizing a mouse model.
[So] Source:J Periodontol;, 2018 Feb 19.
[Is] ISSN:1943-3670
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Peri-implantitis is an inflammatory response to bacterial biofilm resulting in bone loss and can ultimately lead to implant failure. Due to the lack of predictable treatments available, a thorough understanding of peri-implantitis's pathogenesis is essential. The objective of this study is to evaluate and compare the response of acute induced peri-implantitis and periodontitis lesions after insult removal. METHODS: Implants were placed in one-month-old C57BL/6J male mice eight weeks post extraction of their left maxillary molars. Once osseointegrated, ligatures were placed around the implants and contralateral second molars of the experimental groups. Controls did not receive ligatures. After one week, half of the ligatures were removed, creating the ligature-retained and ligature-removed groups. Mice were sacrificed at two time points, five and fourteen days, from ligature removal. The specimens were analyzed via micro-computed tomography and histology. RESULTS: By five and fourteen days after ligature removal, the periodontitis group experienced significant bone gain, while the peri-implantitis group did not. Histologically, all implant groups exhibited higher levels of cellular infiltrate than any of the tooth groups. Osteoclast numbers increased in peri-implantitis and periodontitis ligature-retained groups, and decreased following insult removal. Collagen was overall more disorganized in peri-implantitis than periodontitis for all groups. Peri-implantitis experimental groups revealed greater matrix metalloproteinase-8 and NF-kB levels than periodontitis. CONCLUSIONS: Implants respond slower and less favorably to insult removal than teeth. Future research is needed to characterize detailed peri-implantitis disease pathophysiology. This article is protected by copyright. All rights reserved.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1002/JPER.17-0541

  4 / 22123 MEDLINE  
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[PMID]: 29518512
[Au] Autor:Fok KC; Chan YC; Law Y; Cheng SW
[Ad] Address:Division of Vascular & Endovascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road, Hong Kong.
[Ti] Title:Septic Carotid Endarterectomy Patch as a result of Pre-operative Tooth Extraction.
[So] Source:Ann Vasc Surg;, 2018 Mar 05.
[Is] ISSN:1615-5947
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Infected carotid patch are rare. We present a gentleman who had an elective carotid endarterectomy with Dacron patch closure for symptomatic carotid stenosis under regional anaesthesia, and presented one month later with a discharging sinus at the lower aspect of the neck wound. CT scan showed a rim enhancing collection next to the carotid bifurcation. He subsequently underwent patch excision and repair with autologous saphenous vein graft, with good recovery. Of significance was that he had dental extraction for a loose tooth one day before the index operation as advised by the anesthestist. Streptococcus viridans species, which are part of the normal flora of oral cavity, were isolated from tissue culture. This is the first case in the world's literature of a patient who had Streptococcus viridans carotid patch infection which may be related to his pre-operative tooth extraction.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher

  5 / 22123 MEDLINE  
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[PMID]: 29499242
[Au] Autor:Chatzopoulos GS; Koidou VP; Lunos S; Wolff LF
[Ad] Address:Department of Developmental and Surgical Sciences, Division of Periodontology, School of Dentistry, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN, 55455, USA. Electronic address: chatz005@umn.edu.
[Ti] Title:Implant and root canal treatment: Survival rates and factors associated with treatment outcome.
[So] Source:J Dent;, 2018 Feb 27.
[Is] ISSN:1879-176X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: To assess and compare the survival rates of implant and root canal treatment as well as to investigate the effect of patient and tooth related variables on the treatment outcome in a large-scale population-based study. METHODS: Dental records of patients who received root canal treatment and implant therapy were retrieved from the electronic records of the University of Minnesota School of Dentistry. Demographic characteristics, dental insurance status, socioeconomic status as well as medical history and tobacco use were recorded. The treatment outcome was included as a binary variable (survival/failure). RESULTS: A total of 13,434 records of patients who had implant (33.6%) or root canal therapy (66.4%) were included. The survival rate analysis and Kaplan-Meier table revealed the majority of the implants were removed within the first year (58.8%), while only 35.2% of the root canal treatments failed in the same time period. The overall survival rate was significantly (p < 0.001) higher for implant therapy (98.3%) compared to root canal treatment (72.7%). A statistically significant association was found between treatment (p 
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  6 / 22123 MEDLINE  
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[PMID]: 29464290
[Au] Autor:Kamber R; Papageorgiou SN; Eliades T
[Ad] Address:Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, Plattenstr.11, 8032, Zurich, Switzerland.
[Ti] Title:Hat eine kieferorthopdische Behandlung dauerhafte Auswirkungen auf die Zahnfarbe? : Systematisches Review und Metaanalyse. Does orthodontic treatment have apermanent effect on tooth color? : Asystematic review and meta-analysis.
[So] Source:J Orofac Orthop;79(2):73-82, 2018 Mar.
[Is] ISSN:1615-6714
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:OBJECTIVES: Aim of this systematic review was to assess the effect of orthodontic treatment with fixed appliances on the tooth color of patients. METHODS: Nine databases were searched up to May 2017 for clinical cohort studies on the effect of fixed appliance treatment on tooth color. After elimination of duplicate studies, data extraction, and risk of bias assessment according to the Cochrane guidelines, random effects meta-analyses of mean differences (MD) or means and their 95% confidence intervals (CIs) were performed, followed by GRADE (Grading of Recommendations Assessment, Development and Evaluation) assessment of the quality of evidence. RESULTS: Three nonrandomized and one randomized study with atotal of 138 patients (46% male, 54% female) with average age of 15.7 years were included. Tooth color of treated patients was significantly altered during or after orthodontic treatment (4studies; average of 3.2 ∆E units; 95% CI = 2.0-4.4 ∆E units), which was more than the variation among controls (1study; MD = 1.9 ∆E units; 95% CI = 1.7-2.2 ∆E units). However, the quality of evidence was very low, due to the inclusion of nonrandomized studies, bias, and imprecision. Re-analysis of raw study data indicated that significant differences in clinically discernable treatment-induced color changes were seen between chemically and light-cured adhesives and among the various tooth categories. CONCLUSION: Existing evidence of very low quality indicates that orthodontic treatment might be associated with alterations of tooth color, which are however not consistently clinically discernible. Treatment-induced color alterations might be dependent on bonding material and tooth type, but evidence supporting this is weak.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Process
[do] DOI:10.1007/s00056-018-0123-7

  7 / 22123 MEDLINE  
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Tanaka, Orlando Motohiro
Camargo, Elisa Souza

[PMID]: 29364826
[Au] Autor:Graciano Parra AX; Marin GC; Filho OG; Tanaka OM; Camargo ES
[Ad] Address:Graduate Program in Dentistry, Orthodontics, School of Life Sciences, Pontifica Universidade Catlica do Paran, Prado Velho, Curitiba, Paran, Brazil.
[Ti] Title:Two-phase treatment of anterior open bite.
[So] Source:J Clin Orthod;51(12):801-808, 2017 Dec.
[Is] ISSN:0022-3875
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Open Bite/therapy
[Mh] MeSH terms secundary: Child, Preschool
Extraoral Traction Appliances
Female
Humans
Palatal Expansion Technique
Tooth Extraction
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:D
[Da] Date of entry for processing:180125
[St] Status:MEDLINE

  8 / 22123 MEDLINE  
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[PMID]: 29517801
[Au] Autor:Parkin N; Furness S; Shah A; Thind B; Marshman Z; Glenroy G; Dyer F; Benson PE
[Ad] Address:Academic Unit of Oral Health and Development, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, UK, S10 2TA.
[Ti] Title:WITHDRAWN: Extraction of primary (baby) teeth for unerupted palatally displaced permanent canine teeth in children.
[So] Source:Cochrane Database Syst Rev;3:CD004621, 2018 Mar 08.
[Is] ISSN:1469-493X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The permanent canine tooth in the maxillary (upper) jaw sometimes does not erupt into the mouth correctly. In about 1% to 3% of the population these teeth will be diverted into the roof of the mouth (palatally). It has been suggested that if the primary canine is removed at the right time this palatal eruption might be avoided. This is an update of a Cochrane review first published in 2009. OBJECTIVES: To evaluate the effect of extracting the primary maxillary canine on the eruption of the palatally ectopic maxillary permanent canine. SEARCH METHODS: We searched the following electronic databases: the Cochrane Oral Health Group's Trials Register (to 20 April 2012), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 1), MEDLINE via OVID (1946 to 20 April 2012) and EMBASE via OVID (1980 to 20 April 2012). There were no restrictions regarding language or date of publication. SELECTION CRITERIA: Trials were selected if they met the following criteria: a randomised or quasi-randomised controlled trial, involving the extraction of the deciduous maxillary canine and assessing eruption/non-eruption of the palatally displaced maxillary permanent canine. DATA COLLECTION AND ANALYSIS: Data extraction was undertaken independently by two review authors. The primary outcome was the reported prevalence of eruption or non-eruption of the ectopic permanent canine into the mouth following observation or intervention. Results were to be expressed as risk ratios for dichotomous outcomes with 95% confidence intervals and mean differences for continuous outcomes. Heterogeneity was to be investigated, including both clinical and methodological factors. Authors of trials were contacted to request unpublished data. MAIN RESULTS: Reports of two randomised controlled trials previously excluded from an earlier version of the review due to "deficiencies in reporting, insufficient data" have now been included. These two trials included approximately 128 children, with more than 150 palatally displaced canine teeth, and both were conducted by the same research group. Data presented in the trial reports are either incomplete or inconsistent. Both trials are at high risk of bias. It must be emphasised that both trials have serious deficiencies in the way they were designed, conducted, and reported, and attempts to contact the authors to obtain detailed information and clarify inconsistencies have been unsuccessful. Allocation to treatment appears to be at the level of the individual, but outcomes of successful treatment relate to included teeth and data are not reported for each treatment group. Adverse effects are not reported. Neither trial provides any evidence to guide clinical decision making. AUTHORS' CONCLUSIONS: There is currently no evidence of the effects of extraction of primary canine teeth in 10-13 year old children with one or two palatally displaced permanent canine teeth.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1002/14651858.CD004621.pub4

  9 / 22123 MEDLINE  
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SciELO Brazil full text

[PMID]: 29513885
[Au] Autor:Brandini DA; Amaral MF; Debortoli CVL; Panzarini SR
[Ad] Address:Universidade Estadual Paulista - Unesp, School of Dentistry, Surgery and Integrated Clinics, Araatuba, SP, Brazil.
[Ti] Title:Immediate tooth replantation: root canal filling for delayed initiation of endodontic treatment.
[So] Source:Braz Oral Res;32:e7, 2018 Mar 01.
[Is] ISSN:1807-3107
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:The aim of this study is to evaluate the action of paramonochlorophenol associated with Furacin followed by calcium hydroxide (CH) dressing in the control of inflammatory root resorption in cases of immediate tooth replantation with delayed endodontic treatment. A total of 28 incisors of 3 male dogs were extracted and replanted after 15 minutes, and randomly divided into 3 groups: Group I (n = 8) - endodontic treatment was performed before the extraction and replantation; Group II (n = 10) - endodontic treatment was performed 30 days after replantation and the root canal was filled with CH dressing; Group III (n = 10) - endodontic treatment was performed 30 days after replantation and root canals received temporary medication of paramonochlorophenol-Furacin followed by CH dressing. The animals were euthanized 90 days after replantation. The histomorphological events analyzed at the epithelial reattachment site were the intensity and extent of acute and chronic inflammatory processes, periodontal ligament (PDL) organization, the intensity and extent of acute and chronic inflammatory processes in the PDL space, root resorption, bone tissue, and ankylosis. Data were submitted to the Wilcoxon Signed Ranks Test for group comparison (α = 5%). In Groups I, II and III the periodontal ligament was regenerated and most of the resorption areas were repaired by newly formed cementum. The depth and extent of root resorption were significantly higher in Group II than in Group III. The use of paramonochlorophenol-furacin followed by CH dressing was more effective in controlling inflammatory root resorption after immediate tooth replantation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process

  10 / 22123 MEDLINE  
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[PMID]: 29498969
[Au] Autor:Greene SL; Kau CH; Sittitavornwong S; Powell K; Childers NK; MacDougall M; Lamani E
[Ad] Address:Department of Pediatric.
[Ti] Title:Surgical Management and Evaluation of the Craniofacial Growth and Morphology in Cleidocranial Dysplasia.
[So] Source:J Craniofac Surg;, 2018 Mar 01.
[Is] ISSN:1536-3732
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cleidocranial dysplasia (CCD, MIM 119600) is a rare autosomal dominant disorder affecting bone, cartilage, craniofacial growth, and tooth formation leading to supernumerary teeth. Few reports delineate the genotype-phenotype correlations related to the variations in craniofacial morphology and patterning of the dentition and the complexity of treating patient's malocclusion. Successful management of the craniofacial deformities in patients with CCD requires a multidisciplinary team of healthcare specialists. Approximately 70% of patients are due to point mutations in RUNX2 and <20% due to copy number variations with the remainder unidentified. There is no literature to date, describing the orthognathic management of CCD patients with deletion in one of the RUNX2 alleles. The purpose of this study was to evaluate the craniofacial morphology and dental patterning in a 14-year-old Caucasian female with CCD resulting from a novel microdeletion of RUNX2 in 1 allele. The CCD patient with RUNX2 haploinsufficiency due to microdeletion had decreased craniofacial bone and ankyloses in the permanent dentition. An altered extraction protocol of supernumerary teeth was followed in this patient. Craniofacial growth and morphologic analysis demonstrated atypical skull shape, persistent metopic suture, and decreased mandibular size.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1097/SCS.0000000000004334


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