Database : MEDLINE
Search on : valerianaceae [Words]
References found : 100 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 10 go to page                        

  1 / 100 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29471079
[Au] Autor:Bell CD; Gonzalez LA
[Ad] Address:Department of Biological Sciences, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA 70148, USA. Electronic address: cdbell1@uno.edu.
[Ti] Title:Exploring the utility of "next-generation" sequence data on inferring the phylogeny of the South American Valeriana (Valerianaceae).
[So] Source:Mol Phylogenet Evol;123:44-49, 2018 Feb 19.
[Is] ISSN:1095-9513
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This study aimed to investigate the phylogenetic utility of genotyping-by-sequencing (GBS) data in the southern South American subclade of Valerianaceae (Dipsacales). The variety of forms that has arisen in this clade, presumably over the past 5-10 million years, has all the signatures of an adaptive and rapid radiation. While the phylogeny of Valerianaceae has received a great deal of attention in the last decade, species relationships have been hard to resolve using traditional phylogenetic markers. Here, we collected high-throughput genomic sequence data from reduced-representation libraries obtained through GBS protocols. Putative orthologs were identified using within- and among-sample clustering using the computer software pyRAD. We recovered over 3000 loci for 14 species of southern South AmericanValeriana,with 140 loci present across all samples.We analyzed a set of phylogenetic trees generated from each locus using maximum likelihood methods, as well as multispecies coalescent (∗BEAST) methods. For comparative purposes, we also used a supermatrix approach to infer the phylogeny for these taxa. Across different methods and data sets, we recovered consistent relationships for the southern South American valerians that we sampled with varying degrees of support.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

  2 / 100 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29512454
[Au] Autor:Jalali S; Zarrinhaghighi A; Sadraei S; Ghasemi Y; Sakhteman A; Faridi P
[Ad] Address:Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz. Iran.
[Ti] Title:A Systems Pharmacology Study for Deciphering Anti Depression Activity of Nardostachys jatamansi.
[So] Source:Curr Drug Metab;, 2018 Mar 05.
[Is] ISSN:1875-5453
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Background The plant Nardostachys jatamansi from Valerianaceae family is a well known antidepressant plant and has historically been used in traditional medicine. As N. jatamansi contains many different compounds, to identify its mechanisms of action, we need a network-based study. Network-based studies are becoming an increasingly important tool in understanding the mechanisms of actions of drugs. Systems pharmacology (SP) and bioinformatics are two emerging tools that use computation to develop an understanding of drug actions in molecular and cellular levels. SP can provide mechanistic understanding of protein-protein (drug-target) interaction involved in a common biological pathway. Objectives The present study was undertaken to identify unknown targets and mechanisms of antidepressant activity of N. jatamansi according to a systems pharmacology approach. Methods First of all a list of all the targets (receptors and metabolites) involved in depression process were provided based on KEGG database. The 3D structures of protein targets were collected as PDB files and their active sites coordinates were found. In the next step the structures of known compounds of N. jatamansi were collected. For identifying the protein-lagand interactions, a docking process was run in AutoDock and an output was received. To complete our study, the similarity between antidepressant conventional drugs and N. jatamansi compounds was analyzed. A SP map figured by Cytoscape Software, shows the relations between herbal compounds, molecular targets and depression. Results According to the docking results, we can suggest several important targets that we have no drugs for, or several natural compounds that play an important role in depression process. According to the similarity results we can suggest several molecules for extraction or synthesis that need more researches for their therapeutic effects. Conclusion This study shows that how N. jatamansi can effect on depression by multiple molecular targeting with multiple compounds.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.2174/1389200219666180305151011

  3 / 100 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29221883
[Au] Autor:Yoon CS; Kim KW; Lee SC; Kim YC; Oh H
[Ad] Address:College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea.
[Ti] Title:Anti-neuroinflammatory effects of sesquiterpenoids isolated from Nardostachys jatamansi.
[So] Source:Bioorg Med Chem Lett;28(2):140-144, 2018 01 15.
[Is] ISSN:1464-3405
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Two new nardosinone-type sesquiterpenoids, namely kanshone J (1) and kanshone K (2) along with seven known terpenoids (3-9) were isolated from the rhizomes and roots of Nardostachys jatamansi DC (Valerianaceae). The structures of these compounds were determined mainly by analysis of 1D-, 2D-NMR and MS data. In addition, the absolute configuration of compound 1 was assigned by application of the modified Mosher's method. In an initial assay to evaluate their anti-neuroinflammatory effects, compounds 1-5 and 9 exhibited dose-dependent inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 cells, with IC values ranging from 2.43 to 46.54 M. Particularly, desoxo-narchinol A (3) and narchinol B (4) significantly inhibited LPS-induced NO overproduction in BV2 cells with IC values of 3.48  0.47 and 2.43  0.23 M, respectively. Furthermore, compounds 3 and 4 exhibited anti-neuroinflammatory effects by inhibiting the production of pro-inflammatory mediators, including prostaglandin E (PGE ), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, and pro-inflammatory cytokines, such as interleukin (IL)-1, IL-6, and tumor necrosis factor-α (TNF)-α, in LPS-stimulated BV2 and primary microglial cells.
[Mh] MeSH terms primary: Anti-Inflammatory Agents, Non-Steroidal/pharmacology
Nardostachys/chemistry
Sesquiterpenes/pharmacology
[Mh] MeSH terms secundary: Animals
Anti-Inflammatory Agents, Non-Steroidal/chemistry
Anti-Inflammatory Agents, Non-Steroidal/isolation & purification
Dose-Response Relationship, Drug
Lipopolysaccharides/antagonists & inhibitors
Lipopolysaccharides/pharmacology
Mice
Molecular Structure
Nitric Oxide/antagonists & inhibitors
Nitric Oxide/biosynthesis
Sesquiterpenes/chemistry
Sesquiterpenes/isolation & purification
Structure-Activity Relationship
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Lipopolysaccharides); 0 (Sesquiterpenes); 31C4KY9ESH (Nitric Oxide)
[Em] Entry month:1802
[Cu] Class update date: 180216
[Lr] Last revision date:180216
[Js] Journal subset:IM
[Da] Date of entry for processing:171210
[St] Status:MEDLINE

  4 / 100 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29149840
[Au] Autor:Berger BA; Ricigliano VA; Savriama Y; Lim A; Thompson V; Howarth DG
[Ad] Address:Department of Biological Sciences, St. John's University, 8000 Utopia Parkway, Queens, NY, 11439, USA. brent.a.berger@gmail.com.
[Ti] Title:Geometric morphometrics reveals shifts in flower shape symmetry and size following gene knockdown of CYCLOIDEA and ANTHOCYANIDIN SYNTHASE.
[So] Source:BMC Plant Biol;17(1):205, 2017 Nov 17.
[Is] ISSN:1471-2229
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: While floral symmetry has traditionally been assessed qualitatively, recent advances in geometric morphometrics have opened up new avenues to specifically quantify flower shape and size using robust multivariate statistical methods. In this study, we examine, for the first time, the ability of geometric morphometrics to detect morphological differences in floral dorsoventral asymmetry following virus-induced gene silencing (VIGS). Using Fedia graciliflora Fisch. & Meyer (Valerianaceae) as a model, corolla shape of untreated flowers was compared using canonical variate analysis to knockdown phenotypes of CYCLOIDEA2A (FgCYC2A), ANTHOCYANIDIN SYNTHASE (FgANS), and empty vector controls. RESULTS: Untreated flowers and all VIGS treatments were morphologically distinct from each other, suggesting that VIGS may cause subtle shifts in floral shape. Knockdowns of FgCYC2A were the most dramatic, affecting the position of dorsal petals in relation to lateral petals, thereby resulting in more actinomorphic-like flowers. Additionally, FgANS knockdowns developed larger flowers with wider corolla tube openings. CONCLUSIONS: These results provide a method to quantify the role that specific genes play in the developmental pathway affecting the dorsoventral axis of symmetry in zygomorphic flowers. Additionally, they suggest that ANS may have an unintended effect on floral size and shape.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171126
[Lr] Last revision date:171126
[St] Status:In-Process
[do] DOI:10.1186/s12870-017-1152-x

  5 / 100 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy

[PMID]: 28979324
[Au] Autor:Memariani Z; Hajimahmoodi M; Minaee B; Khodagholi F; Yans A; Rahimi R; Amin G; Moghaddam G; Toliyat T; Sharifzadeh M
[Ad] Address:Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Title:Protective Effect of a Polyherbal Traditional Formula Consisting of Mill., L. And DC., Against Ethanol-induced Gastric Ulcer.
[So] Source:Iran J Pharm Res;16(2):694-707, 2017.
[Is] ISSN:1735-0328
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:"VARD" formula consisting of Mill. (Rosaceae) petals, and rhizomes of L. (Papilionaceae) and DC. (Valerianaceae), has been proposed for gastric ulcer in Iranian traditional medicine. We investigated the antiulcer activity of each plant separately and in combination. The biochemical and molecular functions of extracts were also evaluated. Each plant hydroalcoholic extract was standardized via determination of total phenolic and flavonoid contents, also via some phenolic compounds determination and specially glycyrrhizic acid in by using HPLC. Rats received orally extracts of the plants (20, 40 and 80 mg/Kg) and "VARD" (45 mg/Kg) 1 h before ethanol administration. Two h after receiving ethanol, animals were sacrificed; the stomach was removed for macroscopic and microscopic assessment. Also heme-oxygenase-1, glutathione, and catalase were measured in the gastric tissue of the rats pretreated by "VARD" and dose of 20 mg/Kg of extracts. Among three extracts, and contained more total phenolic and flavonoid content respectively. Gallic acid was prominent compound in The extracts of , , and significantly decreased ulcer index. ED values were 8.2, 31.86 and 25.08 mg/Kg respectively. "VARD" significantly decreased ulcer index compared to 20 mg/Kg of ( < 0.0001) and ( < 0.001). Pretreatment with "VARD" and each plant extracts (20 mg/Kg) increased glutathione, catalse and heme-oxygenase-1 significantly ( < 0.05 in comparison with control group. Our findings indicate that "VARD" partly via antioxidant activity can be considered as an effective antiulcer formula.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171008
[Lr] Last revision date:171008
[St] Status:PubMed-not-MEDLINE

  6 / 100 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28649852
[Au] Autor:Wang MY; Zhai YS; Liang CH
[Ad] Address:b School of Traditional Chinese Medicine, Capital Medical University , Beijing 100069 , China.
[Ti] Title:Two new guaiane-type sesquiterpenoids from Valeriana hardwickii and their cytotoxicity.
[So] Source:J Asian Nat Prod Res;19(10):987-992, 2017 Oct.
[Is] ISSN:1477-2213
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Two new guaiane-type sesquiterpenoids, named 4α,5α-epoxy-8-hydroxy-1α-hydro-α-guaiene (1) and 4α,5α-epoxy-1-hydroxy-α-guaiene (2), were isolated from the whole plants of Valeriana hardwickii. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1 and 2 showed weak cytotoxicity against the lung adenocarcinoma (A549) and hepatoma (Bel7402) cell lines with IC values of 9.2 and 8.5M, respectively.
[Mh] MeSH terms primary: Antineoplastic Agents, Phytogenic/isolation & purification
Drugs, Chinese Herbal/isolation & purification
Sesquiterpenes, Guaiane/isolation & purification
Valerian/chemistry
[Mh] MeSH terms secundary: A549 Cells
Antineoplastic Agents, Phytogenic/chemistry
Antineoplastic Agents, Phytogenic/pharmacology
Azulenes
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal/chemistry
Drugs, Chinese Herbal/pharmacology
Humans
Inhibitory Concentration 50
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Paclitaxel/pharmacology
Sesquiterpenes, Guaiane/chemistry
Sesquiterpenes, Guaiane/pharmacology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (4alpha,5alpha-epoxy-1-hydroxy-alpha-guaiene); 0 (4alpha,5alpha-epoxy-8beta-hydroxy-1alpha-hydro-alpha-guaiene); 0 (Antineoplastic Agents, Phytogenic); 0 (Azulenes); 0 (Drugs, Chinese Herbal); 0 (Sesquiterpenes, Guaiane); 88-84-6 (guaiene); P88XT4IS4D (Paclitaxel)
[Em] Entry month:1710
[Cu] Class update date: 171003
[Lr] Last revision date:171003
[Js] Journal subset:IM
[Da] Date of entry for processing:170627
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2017.1339350

  7 / 100 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 27924641
[Au] Autor:Lin S; Fu P; Chen T; Ye J; Yang XW; Zhang WD
[Ad] Address:a Department of Natural Product Chemistry , School of Pharmacy, Second Military Medical University , Shanghai 200433 , China.
[Ti] Title:Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity.
[So] Source:J Asian Nat Prod Res;19(1):15-21, 2017 Jan.
[Is] ISSN:1477-2213
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Three new minor valepotriate isomers, jatamanvaltrates Z1 (1), Z2 (2), and Z3 (3), have been isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii.). Their structures were elucidated by extensive spectroscopic analysis, especially 2D NMR and ESI-MS/MS . All isolated compounds displayed moderate cytotoxicity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines with IC values of 2.8-8.3M.
[Mh] MeSH terms primary: Antineoplastic Agents, Phytogenic/isolation & purification
Antineoplastic Agents, Phytogenic/pharmacology
Drugs, Chinese Herbal/isolation & purification
Drugs, Chinese Herbal/pharmacology
Iridoids/isolation & purification
Iridoids/pharmacology
Valerian/chemistry
[Mh] MeSH terms secundary: Antineoplastic Agents, Phytogenic/chemistry
Colonic Neoplasms/drug therapy
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal/chemistry
Humans
Inhibitory Concentration 50
Iridoids/chemistry
Isomerism
Male
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Roots/chemistry
Prostatic Neoplasms/drug therapy
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antineoplastic Agents, Phytogenic); 0 (Drugs, Chinese Herbal); 0 (Iridoids); 0 (jatamanvaltrate Z1); L3JQ035X9B (valtrate)
[Em] Entry month:1702
[Cu] Class update date: 170208
[Lr] Last revision date:170208
[Js] Journal subset:IM
[Da] Date of entry for processing:161208
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1258065

  8 / 100 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 27832992
[Au] Autor:Zhu J; Xu K; Zhang X; Cao J; Jia Z; Yang R; Ma C; Chen C; Zhang T; Yan Z
[Ad] Address:School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
[Ti] Title:Studies on the regulation of lipid metabolism and its mechanism of the iridoids rich fraction in Valeriana jatamansi Jones.
[So] Source:Biomed Pharmacother;84:1891-1898, 2016 Dec.
[Is] ISSN:1950-6007
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:Valeriana jatamansi Jones, a plant with heart-shaped leaves in the Valeriana genus of Valerianaceae, is widely used in Chinese folk medicine. Iridoid is an important constituent of V. jatamansi that contributes to the pharmacological efficacy of the herb. This study aims to investigate the regulation of lipid metabolism and its mechanism of the iridoids rich fraction in V. jatamansi (IRFV). A high fat diet was used to establish the hyperlipidemia rat model, with 2mg/kg/d of simvastatin as a positive control, fed with 7.5, 15, and 30mg/kg/d of IRFV for 20days to investigate the lipid regulation activity and mechanism of IRFV. Body weight, liver index, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in both serum and liver, as well as total bile acid (TBA), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in serum were measured. The lipoprotein lipase (LPL) and hepatic lipase (HL) activities and the apoprotein A5 (ApoA5), peroxisome proliferator-activated receptor α (PPAR-α), sterol regulatory element-binding proteins (SREBP-1c), and liver X receptor α (LXR-α) protein expressions were observed. Liver pathology was described through hematoxylin-eosin (HE) staining. Compared with the model group, three different IRFV dosages can slow down the weight gain of rats, reduce the contents of TG, and increase the contents of HDL-C in serum. Low IRFV dosage can significantly reduce the AST and ALT contents in serum, liver index, and the TG contents in liver, enhance LPL activity. Medium IRFV dosage can significantly decrease the TG and LDL-C contents in liver. High IRFV dosage can significantly reduce LDL-C, TBA, AST, and ALT contents in serum, and enhance HL activity. Three different IRFV dosages can significantly increase the ApoA5 and PPAR-α protein expression and decrease the SREBP-1c protein expression. Furthermore, the LXR-α protein expression decreased in low- and high-dose groups. Liver tissue pathological observation showed that IRFV can improve cell degeneration to a certain extent. These results strongly suggest that IRFV play significant roles in regulating lipid metabolism, the mechanism may be related to the increased ApoA5 protein expression.
[Mh] MeSH terms primary: Iridoids/pharmacology
Lipid Metabolism/drug effects
Lipid Metabolism/physiology
Plant Extracts/pharmacology
Valerian
[Mh] MeSH terms secundary: Animals
Female
Iridoids/isolation & purification
Liver/drug effects
Liver/metabolism
Liver/pathology
Male
Plant Extracts/isolation & purification
Plant Roots
Rats
Rats, Sprague-Dawley
Rhizome
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Iridoids); 0 (Plant Extracts)
[Em] Entry month:1702
[Cu] Class update date: 170921
[Lr] Last revision date:170921
[Js] Journal subset:IM
[Da] Date of entry for processing:161112
[St] Status:MEDLINE

  9 / 100 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 26155822
[Au] Autor:Xiang Z; Chen N; Xu Y; Wu J; Liu YJ; Tan C; Ji YB; Li WL
[Ad] Address:a Center of Research on Life Science and Environmental Science, Harbin University of Commerce , Harbin , PR China.
[Ti] Title:New flavonoid from Patrinia villosa.
[So] Source:Pharm Biol;54(7):1219-22, 2016 Jul.
[Is] ISSN:1744-5116
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: Patrinia villosa (Thunb.) Juss (Valerianaceae) is an important ancient herbal medicine widely used for inflammation, wound healing, and abdominal pain. But little is known of the phytochemical constituents of this herbal plant. OBJECTIVE: The objective of this study is to isolate and identify the bioactive components from P. villosa. MATERIALS AND METHODS: A 70% EtOH extract of P. villosa was subjected to normal-phase silica, ODS silica gel column chromatography, and semi-preparative HPLC chromatography after partitioned successively with light petroleum, dichloromethane and n-BuOH. Chemical structures of the compounds were elucidated by spectroscopic methods including UV, 1D-NMR, 2D-NMR, HR-ESI-MS, and CD spectra. The cytotoxic activity of the new component was determined with the SMMC-7721 cell line using the MTT method after incubation for 48 h. RESULTS: A new flavonoid named patriniaflavanone A (1) along with four known compounds was isolated from P. villosa. The four known compounds were identified as luteolin 7-O-glucuronide-6″-methyl ester (2), p-hydroxyphenylacetic acid methyl ester (3), trans-caffeic acid (4), and trans-caffeic acid methylate (5) by comparison of their spectral data with the reported data. The IC50 value of patriniaflavanone A (1) on SMMC-7721 was 61.27 M. DISCUSSION AND CONCLUSION: This is the first report on the isolation and identification of patriniaflavanone A (1), and compounds 2-5 were isolated for the first time from the title plant. Patriniaflavanone A (1) exhibited moderate cytotoxic activity.
[Mh] MeSH terms primary: Antineoplastic Agents, Phytogenic/isolation & purification
Flavonoids/isolation & purification
Patrinia/chemistry
[Mh] MeSH terms secundary: Antineoplastic Agents, Phytogenic/pharmacology
Carcinoma, Hepatocellular/drug therapy
Carcinoma, Hepatocellular/pathology
Cell Line, Tumor
Cell Survival/drug effects
Chromatography, High Pressure Liquid
Circular Dichroism
Flavonoids/pharmacology
Humans
Liver Neoplasms/drug therapy
Liver Neoplasms/pathology
Magnetic Resonance Spectroscopy
Molecular Structure
Phytotherapy
Plant Leaves
Plants, Medicinal
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antineoplastic Agents, Phytogenic); 0 (Flavonoids)
[Em] Entry month:1702
[Cu] Class update date: 170207
[Lr] Last revision date:170207
[Js] Journal subset:IM
[Da] Date of entry for processing:150710
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1064449

  10 / 100 MEDLINE  
              first record previous record
select
to print
Photocopy
PubMed Central Full text

[PMID]: 26798180
[Au] Autor:Pundarikakshudu K; Bhatt CJ
[Ad] Address:L. J. Institute of Pharmacy, L. J. Campus, Between Sarkhej Circle and Kataria Motors, Ahmedabad-382 210, India.
[Ti] Title:Design, Development and Rationalization of Sarpagandha Ghanvati.
[So] Source:Indian J Pharm Sci;77(5):626-30, 2015 Sep-Oct.
[Is] ISSN:0250-474X
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Sarpagandha ghanvati is a classical Ayurvedic formulation widely prescribed for anxiety and insomnia. It contains Sarpagandha (roots of Rauwolfia serpentina L. (Benth.) Ex Kurz; Family: Apocyanaceae), Khurasani ajowan (Hyocyamus niger L.; Family: Solanaceae) seeds, Jatamansi (Nardostachys jatamansi DC. Family: Valerianaceae) roots and Pipplamul (root of Piper longum L.; Family: Piperaceae). The objective of this study was to make a comparative evaluation of Ghanvatis and tablets of this formulation. Two tablet formulations were prepared; one incorporating only powders of all ingredients; the other with ethanol extracts of the first three ingredients and powder of Piper longum root. Similarly, two types of Sarpagandha ghanvati pills were prepared; one as per Ayurvedic Formulary of India; the other with ethanol extracts of the first three ingredients and powder of Piper longum root. Alcohol extracted 0.22% w/w of total alkaloids as against 0.061% w/w extracted by water. Tablets prepared with powders of all the ingredients had friability more than 3.0% where as those prepared with ethanol extract had very low friability. Ghanvatis, prepared as per the Ayurvedic formulary, did not show reserpine although other alkaloids were present. They showed less content uniformity and lower drug release. Ethanol extracted reserpine along with other alkaloids. Ghanvatis made with the alcoholic extracts exhibited better content uniformity and drug release than the traditional formulation. Tablets prepared with powders or extracts of the ingredients exhibited good content uniformity but the release of alkaloids from the tablets of powders was only 80%. Tablets of the extracts had good content uniformity with 90% release of the total alkaloids. Tablets prepared with alcoholic extracts using 1% polyvinylpyrrolidone as binder and 5% dried starch powder as disintegrating agent confirmed to all the requirements. Thus, the study shows tablets made with the extracts are superior to Ghanvatis and powder tablets.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Cu] Class update date: 160124
[Lr] Last revision date:160124
[Da] Date of entry for processing:160123
[St] Status:PubMed-not-MEDLINE


page 1 of 10 go to page                        
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information