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[PMID]: 29507099
[Au] Autor:Stamler J; Chan Q; Daviglus ML; Dyer AR; Van Horn L; Garside DB; Miura K; Wu Y; Ueshima H; Zhao L; Elliott P; INTERMAP Research Group
[Ad] Address:From the Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (J.S., M.L.D., A.R.D., L.V.H.); Institute for Minority Health Research, University of Illinois, Chicago (M.L.D., D.B.G.); Department of Epidemiology and Biostatistics, School of Public Healt
[Ti] Title:Relation of Dietary Sodium (Salt) to Blood Pressure and Its Possible Modulation by Other Dietary Factors: The INTERMAP Study.
[So] Source:Hypertension;71(4):631-637, 2018 Apr.
[Is] ISSN:1524-4563
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Available data indicate that dietary sodium (as salt) relates directly to blood pressure (BP). Most of these findings are from studies lacking dietary data; hence, it is unclear whether this sodium-BP relationship is modulated by other dietary factors. With control for multiple nondietary factors, but not body mass index, there were direct relations to BP of 24-hour urinary sodium excretion and the urinary sodium/potassium ratio among 4680 men and women 40 to 59 years of age (17 population samples in China, Japan, United Kingdom, and United States) in the INTERMAP (International Study on Macro/Micronutrients and Blood Pressure), and among its 2195 American participants, for example, 2 SD higher 24-hour urinary sodium excretion (118.7 mmol) associated with systolic BP 3.7 mm Hg higher. These sodium-BP relations persisted with control for 13 macronutrients, 12 vitamins, 7 minerals, and 18 amino acids, for both sex, older and younger, blacks, Hispanics, whites, and socioeconomic strata. With control for body mass index, sodium-BP-but not sodium/potassium-BP-relations were attenuated. Normal weight and obese participants manifested significant positive relations to BP of urinary sodium; relations were weaker for overweight people. At lower but not higher levels of 24-hour sodium excretion, potassium intake blunted the sodium-BP relation. The adverse association of dietary sodium with BP is minimally attenuated by other dietary constituents; these findings underscore the importance of reducing salt intake for the prevention and control of prehypertension and hypertension. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00005271.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180311
[Lr] Last revision date:180311
[Cl] Clinical Trial:ClinicalTrial
[St] Status:In-Data-Review
[do] DOI:10.1161/HYPERTENSIONAHA.117.09928

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[PMID]: 29499310
[Au] Autor:Koh EJ; Kim KJ; Choi J; Kang DH; Lee BY
[Ad] Address:Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam, Kyonggi, 13488, Republic of Korea.
[Ti] Title:Spirulina maxima extract prevents cell death through BDNF activation against amyloid beta 1-42 (Aß ) induced neurotoxicity in PC12 cells.
[So] Source:Neurosci Lett;673:33-38, 2018 Feb 27.
[Is] ISSN:1872-7972
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Spirulina maxima is a blue-green micro alga that contains abundant amounts of proteins (60-70%), vitamins, chlorophyll a, and C-phycocyanin (C-PC). It has been shown to reduce oxidative stress, and prevent diabetes and non-alcoholic fatty liver disease. However, it is unclear whether Spirulina maxima 70% ethanol extract (SM70EE), chlorophyll a, and C-PC prevent Aß -induced neurotoxicity in PC12 cells. The aim of this study was to investigate whether SM70EE, chlorophyll a, and C-PC prevent Aß -induced cell death. SM70EE, chlorophyll a, and C-PC suppressed the Aß -induced increase in poly-ADP ribose polymerase-1 (PARP-1) cleavage and reduced Aß -induced decreases in glutathione and its associated factors. The level of brain-derived neurotrophic factor (BDNF), which plays a critical role in neuronal survival and neuroprotection, was increased by SM70EE, chlorophyll a, and C-PC in Aß -treated cells. SM70EE treatment decreased oxidative stress and cell death in response to Aß treatment, while simultaneously suppressing PARP cleavage and increasing the levels of glutathione (GSH) and its associated factors. Moreover, SM70EE lowered the levels of APP and BACE1, two major factors involved in APP processing, and increased BDNF expression during Aß -induced neurotoxicity in PC12 cells. We suggest that SM70EE prevents cell death caused by Aß -induced neurotoxicity via the activation of BDNF signaling.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29471004
[Au] Autor:Chhabra G; Singh CK; Ndiaye MA; Fedorowicz S; Molot A; Ahmad N
[Ad] Address:Department of Dermatology, University of Wisconsin, Madison, WI, USA.
[Ti] Title:Prostate cancer chemoprevention by natural agents: Clinical evidence and potential implications.
[So] Source:Cancer Lett;422:9-18, 2018 Feb 20.
[Is] ISSN:1872-7980
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Prostate cancer (PCa) is the most common non-skin cancer and the second leading cause of cancer-related deaths in American men. Due to its long latency period, PCa is considered as an ideal cancer type for chemopreventive interventions. Chemopreventive agents include various natural or synthetic agents that prevent or delay cancer development, progression and/or recurrence. Pre-clinical studies suggest that many natural products and dietary agents have chemopreventive properties. However, a limited number of these agents have been tested in clinical trials, with varying success. In this review, we have discussed the available clinical studies regarding the efficacy of natural chemopreventive agents against PCa, including tea polyphenols, selenium, soy proteins, vitamins and resveratrol. We have also provided a discussion on the clinical challenges and opportunities for the potential use of chemopreventive agents against PCa. Based on available literature, it appears that the variable outcomes of the chemopreventive clinical studies necessitate a need for additional studies with more rigorous designs and methodical interpretations in order to measure the potential of the natural agents against PCa.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:Publisher

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[PMID]: 29523536
[Au] Autor:Popoola VO; Lau BD; Tan E; Shaffer DL; Kraus PS; Farrow NE; Hobson DB; Aboagye JK; Streiff MB; Haut ER
[Ad] Address:Division of Acute Care Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
[Ti] Title:Nonadministration of medication doses for venous thromboembolism prophylaxis in a cohort of hospitalized patients.
[So] Source:Am J Health Syst Pharm;75(6):392-397, 2018 Mar 15.
[Is] ISSN:1535-2900
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: Results of a study to characterize patterns of nonadministration of medication doses for venous thromboembolism (VTE) prevention among hospitalized patients are presented. METHODS: The electronic records of all patients admitted to 4 floors of a medical center during a 1-month period were examined to identify patients whose records indicated at least 1 nonadministered dose of medication for VTE prophylaxis. Proportions of nonadministered doses by medication type, intended route of administration, and VTE risk categorization were compared; reasons for nonadministration were evaluated. RESULTS: Overall, 12.7% of all medication doses prescribed to patients in the study cohort ( = 75) during the study period (857 of 6,758 doses in total) were not administered. Nonadministration of 1 or more doses of VTE prophylaxis medication was nearly twice as likely for subcutaneous anticoagulants than for all other medication types (231 of 1,112 doses [20.8%] versus 626 of 5,646 doses [11.2%], < 0.001). For all medications prescribed, the most common reason for nonadministration was patient refusal (559 of 857 doses [65.2%]); the refusal rate was higher for subcutaneous anticoagulants than for all other medication categories (82.7% versus 58.8%, < 0.001). Doses of antiretrovirals, immunosuppressives, antihypertensives, psychiatric medications, analgesics, and antiepileptics were less commonly missed than doses of electrolytes, vitamins, and gastrointestinal medications. CONCLUSION: Scheduled doses of subcutaneous anticoagulants for hospitalized patients were more likely to be missed than doses of all other medication types.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review
[do] DOI:10.2146/ajhp161057

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[PMID]: 29447176
[Au] Autor:Svefors P; Selling KE; Shaheen R; Khan AI; Persson LÅ; Lindholm L
[Ad] Address:International Maternal and Child Health, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
[Ti] Title:Cost-effectiveness of prenatal food and micronutrient interventions on under-five mortality and stunting: Analysis of data from the MINIMat randomized trial, Bangladesh.
[So] Source:PLoS One;13(2):e0191260, 2018.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Nutrition interventions may have favourable as well as unfavourable effects. The Maternal and Infant Nutrition Interventions in Matlab (MINIMat), with early prenatal food and micronutrient supplementation, reduced infant mortality and were reported to be very cost-effective. However, the multiple micronutrients (MMS) supplement was associated with an increased risk of stunted growth in infancy and early childhood. This unfavourable outcome was not included in the previous cost-effectiveness analysis. The aim of this study is to evaluate whether the MINIMat interventions remain cost-effective in view of both favourable (decreased under-five-years mortality) and unfavourable (increased stunting) outcomes. METHOD: Pregnant women in rural Bangladesh, where food insecurity still is prevalent, were randomized to early (E) or usual (U) invitation to be given food supplementation and daily doses of 30 mg, or 60 mg iron with 400 µg of folic acid, or MMS with 15 micronutrients including 30 mg iron and 400 µg of folic acid. E reduced stunting at 4.5 years compared with U, MMS increased stunting at 4.5 years compared with Fe60, while the combination EMMS reduced infant mortality compared with UFe60. The outcome measure used was disability adjusted life years (DALYs), a measure of overall disease burden that combines years of life lost due to premature mortality (under five-year mortality) and years lived with disability (stunting). Incremental cost effectiveness ratios were calculated using cost data from already published studies. RESULTS: By incrementing UFe60 (standard practice) to EMMS, one DALY could be averted at a cost of US$24. CONCLUSION: When both favourable and unfavourable outcomes were included in the analysis, early prenatal food and multiple micronutrient interventions remained highly cost effective and seem to be meaningful from a public health perspective.
[Mh] MeSH terms primary: Growth Disorders/etiology
Infant Nutritional Physiological Phenomena/economics
Micronutrients/therapeutic use
[Mh] MeSH terms secundary: Adult
Bangladesh/epidemiology
Child, Preschool
Cost-Benefit Analysis/methods
Dietary Supplements
Female
Folic Acid
Food Supply
Growth Disorders/drug therapy
Growth Disorders/mortality
Humans
Infant
Infant Mortality
Infant Nutritional Physiological Phenomena/drug effects
Infant Nutritional Physiological Phenomena/physiology
Infant, Newborn
Iron
Male
Micronutrients/administration & dosage
Nutrition Policy
Pregnancy
Prenatal Care
Prenatal Nutritional Physiological Phenomena
Trace Elements
Vitamins
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Micronutrients); 0 (Trace Elements); 0 (Vitamins); 935E97BOY8 (Folic Acid); E1UOL152H7 (Iron)
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:IM
[Da] Date of entry for processing:180216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191260

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[PMID]: 29521263
[Au] Autor:Salinas-Casado J; Méndez-Rubio S; Esteban-Fuertes M; Gómez-Rodríguez A; Vírseda-Chamorro M; Luján-Galán M; Rituman G
[Ad] Address:Servicio de Urología. Hospital Clínico San Carlos. Madrid. España.
[Ti] Title:Eficacia y tolerancia terapéutica de la D­manosa (2 g) de liberación prolongada 24 horas (asociada a proantocianidinas), frente a proantocianidinas aisladas en el manejo de una serie de mujeres con infecciones urinarias recurrentes. [Efficacy and safety of D-mannose (2 g), 24h prolonged release, associated with Proanthocyanidin (PAC), versus isolate PAC, in the management of a series of women with recurrent urinary infections.]
[So] Source:Arch Esp Urol;71(2):169-177, 2018 Mar.
[Is] ISSN:0004-0614
[Cp] Country of publication:Spain
[La] Language:spa
[Ab] Abstract:OBJECTIVE: To compare the efficacy and safety of dietary supplement "Manosar®" composed of D-mannose (2 g), 24 h prolonged release, associated with Proanthocyanidin (PAC) (140 mg), ursolic acid (7.98 mg), A, C, and D vitamins and the oligoelement zinc, versus 240 mg of PAC in recurrent urinary tract infections (UTI), for a designed follow-up of 24 weeks, in women. METHODS: A multicenter randomized experimental double-blind study was carried out. The study was approved by review board of "Complejo Hospitalario de Toledo" (Spain), and all patients gave informed consent. A total of 150 women with non complicated UTI were screened for participation. Valid data was obtained from 93, with mean age of 48 years. Fortyfour patients were assigned to the Manosar® group and 51 patients to the PAC group. Patients were followed during six months. A previous UTI was defined based on a combination of symptoms and a positive reactive urine trip. Confirmation of a new UTI was based on symptoms, reactive urine strip and urine culture. RESULTS: Thirty-three patients (35%) had an UTI during the six months follow-up. The percentage of UTI of the Manosar® group during this period was 24%, while the percentage of the PAC group was 45% (p〈0.05). The disease-free time for the Manosar® group was 95 days, while this time was 79 days for the PAC group. The incidence of side effects was low. Diarrhea was the most frequent side-effect in both groups. CONCLUSION: Manosar® (oral once a day) is more effective than single dose PAC (240 mg daily orally) to prevent recurrent UTI in women.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

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[PMID]: 29521205
[Au] Autor:Blanchet M; Brunel JM
[Ad] Address:Centre de Recherche en Cancerologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes; Aix-Marseille Université, UM 105; Inserm, U1068, F-13009, Marseille. France.
[Ti] Title:Bile Acid Derivatives: From Old Molecules to a New Potent Therapeutical Use: an Overview.
[So] Source:Curr Med Chem;, 2018 Mar 08.
[Is] ISSN:1875-533X
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Bile acids or bile salts, belong to a large family of biological steroid derivatives found predominantly in the bile of mammals and other vertebrates. These amphipathic molecules possess numerous functions, including eliminating cholesterol from the body, driving the flow of bile to eliminate catabolites, emulsifying fat-soluble vitamins to enable their absorption, aiding in motility and in reducing the bacteria flora found in the small intestine and biliary tract. In this review, we investigate progress towards synthetic bile acid derivatives, with special emphasis on how they might be used for various biological applications and the challenges that remain in developing these compounds as potent drugs of the future especially in the field of microbiology (antimicrobial activities) and cancer (anticancer agents). We will emphasize the fact that even few researches are devoted around these peculiar structures al the researches pointed out the important potential of such derivatives for the design of new classes of drugs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.2174/0929867325666180309113737

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[PMID]: 29520704
[Au] Autor:Asghari G; Khalaj A; Ghadimi M; Mahdavi M; Farhadnejad H; Valizadeh M; Azizi F; Barzin M; Hosseinpanah F
[Ad] Address:Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[Ti] Title:Prevalence of Micronutrient Deficiencies Prior to Bariatric Surgery: Tehran Obesity Treatment Study (TOTS).
[So] Source:Obes Surg;, 2018 Mar 08.
[Is] ISSN:1708-0428
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Micronutrient deficiencies are major concerns after bariatric surgery, although these conditions often go undiagnosed pre-surgery. OBJECTIVE: To assess pre-surgery micronutrient status of an Iranian population of morbidly obese candidates of bariatric surgery in a cross-sectional study. METHODS: A cross-sectional analysis of 2008 candidates for bariatric surgery, aged 15-65 years, with either body mass index (BMI) ≥ 40 kg/m or 30 < BMI < 35 kg/m with a medical comorbidity was conducted. In order to determine the micronutrient status of participants, blood samples were collected to assess serum concentrations of vitamins (B12 and D), minerals (copper, calcium, phosphate, and zinc), and iron profiles (total iron binding capacity, iron concentration, ferritin, and iron saturation), according to standard protocol. RESULTS: The mean age and BMI of patients (79.3% female) were 37.8 years and 44.8 kg/m , respectively. Deficiencies were found for 25(OH) D (53.6%), vitamin B12 (34.4%), serum iron (10.2%), and low levels of hemoglobin (16.6%). The prevalence of other deficiencies were all below 10%. Body mass index had a negative correlation with iron, calcium, vitamin B12, and 25(OH) D and was positively correlated with copper. CONCLUSION: Micronutrient deficiencies, including vitamin D, vitamin B12, and iron, are commonly found among morbidly obese subjects who are potential candidates of bariatric surgery.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1007/s11695-018-3187-y

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[PMID]: 29519632
[Au] Autor:Paduraru L; Dimitriu DC; Avasiloaiei AL; Moscalu M; Zonda GI; Stamatin M
[Ad] Address:Division of Neonatology, Department of Mother and Child Care, "Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania.
[Ti] Title:Total antioxidant status in fresh and stored human milk from mothers of term and preterm neonates.
[So] Source:Pediatr Neonatol;, 2018 Feb 08.
[Is] ISSN:2212-1692
[Cp] Country of publication:Singapore
[La] Language:eng
[Ab] Abstract:BACKGROUND: Antioxidant defense of the body is assured by both endogenous and exogenous factors comprising several enzymes, vitamins, protein components and derivates and oligoelements. Breast milk has been proven to have important and essential antioxidant composition to prevent and protect against diseases in infancy. The objective of this study was to determine the total antioxidant status (TAS) of human milk and to evaluate the differences between premature milk and term milk at different moments of lactation (colostrum, transitional milk and mature milk). A second objective was to evaluate how TAS varies whether the human milk is refrigerated or frozen. METHODS: Pumped human milk samples of the third, seven and 30th day were collected from women who had term deliveries (30 cases) and preterm deliveries (60 cases). Samples were refrigerated (+4 °C) or frozen in domestic conditions (-20 °C) for various durations and TAS was determined using the ABTS® technique with Randox® reagents and compared for the two groups. RESULTS: Higher values were found in term versus preterm fresh milk at 30 days of lactation. A slight reduction in TAS was found after 72 h of refrigeration, while 1 week freezing produced significant decrease of total antioxidants. Freezing for 12 weeks reduced more than 50% of TAS in fresh milk. CONCLUSION: Breastfeeding provides the optimal antioxidant for neonates, regardless of gestational age. Fresh milk has the higher antioxidant power. When it is not available, refrigerated milk for 24 h is better than for 72 h and preferable than frozen milk. Freezing human milk for 3 months in household conditions markedly diminishes TAS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

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[PMID]: 29519118
[Au] Autor:Zapolska J; Witczak-Sawczuk K; Krawczuk-Rybak M; Sawicka-Zukowska M; Smarkusz J; Ostrowska L
[Ad] Address:Department of Dietetics and Clinical Nutrition, Faculty of Health Sciences, Medical University of Bialystok, Poland
[Ti] Title:Comparison of diet and physical activity of children and adolescents with patients after cancer treatment
[So] Source:Rocz Panstw Zakl Hig;69(1):79-86, 2018.
[Is] ISSN:0035-7715
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Background: Properly balanced diet and exercise are an essential element of healthy living for children and adolescents. Particular attention should be paid to nutrition and physical activity among juniors after cancer treatment, which is one of the most important elements of the convalescence period. Objective: The aim of the study was a comparative analysis of diet, physical activity of healthy children and adolescents with patients after cancer treatment. Material and methods: The study involved 60 children and adolescents; 30 healthy juniors and 30 patients after treatment for cancer. An analysis of diets based on a 3-day 24-hour nutrition diary. The questionnaire surveyed collected data about participation and physical activity preferences. Statistical program-Statistica 12.0, published by StatSoft, was used to develop the results. Results: Both groups were characterized by increased consumption of proteins and carbohydrates. Insufficient fat intake was shown in comparison with the recommended amounts in all study groups. It was observed that in the group of patients after treatment, vitamins B1, A, E and D intake was higher than in their healthy peers. Determinants of the choice of physical activity among children after cancer treatment was pleasure and fun, while among their healthy peers, aesthetic considerations (taking care of appearance). Conclusions: Children and adolescents after cancer treatmentin a much greater percentage covered of daily intake of nutrients than healthy children, and more willingly spent time on physical activity. Greater interest in physical activity in this group was probably due to previous restrictions related to illness and therapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review


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