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[PMID]: 29267481
[Au] Autor:Damiani L; Quadros M; Posser V; Minotto R; Boff AL
[Ad] Address:Dermatology Service of Santa Casa de Misericórdia Porto Alegre - Porto Alegre (RS), Brazil.
[Ti] Title:Zoon vulvitis.
[So] Source:An Bras Dermatol;92(5 Suppl 1):166-168, 2017.
[Is] ISSN:1806-4841
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Zoon vulvitis or vulvitis chronica plasmacellularis is a rare, chronic benign inflammation of the vulvar mucosa, diagnosed histologically, with variable therapeutic responses. It is important to be diagnosed because it mimics the presentation of other genital conditions, such as lichen planus and squamous cell carcinoma, which require specific treatment. We report a case of a female patient with three asymptomatic shallow ulcers on the labia minora. Laboratory tests ruled out infectious diseases and the biopsy was consistent with Zoon Vulvitis.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1712
[Cu] Class update date: 171224
[Lr] Last revision date:171224
[St] Status:In-Process

  2 / 731 MEDLINE  
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[PMID]: 29271860
[Au] Autor:Day T; Knight V; Dyall-Smith D; Dennerstein G; Pagano R; Tran H; Tan Y; Yap D; Weigner J; Scurry J
[Ad] Address:Maternity and Gynecology, John Hunter Hospital, Newcastle, Australia.
[Ti] Title:Interpretation of Nondiagnostic Vulvar Biopsies.
[So] Source:J Low Genit Tract Dis;22(1):74-81, 2018 Jan.
[Is] ISSN:1526-0976
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of the study was to assess clinical and histopathologic characteristics of symptomatic women who underwent a nondiagnostic biopsy of the inner vulva. MATERIALS AND METHODS: Consecutive nondiagnostic biopsies from medial labia minora, posterior fourchette, and vestibule obtained from symptomatic women between 2011 and 2015 were reviewed for this retrospective histopathologic case series. Histopathologic assessment included site, basal layer appearance, lymphocytic infiltrate, and presence of fibrosis or sclerosis. Examination findings, treatment, initial impression, and final clinical diagnosis were recorded. Descriptive statistics were performed; clinical and histopathologic characteristics were compared with Fisher exact test. RESULTS: There were 85 cases; mean age was 53 years. Most women presented with painful erythema and underwent biopsy to confirm (30, 35%) or exclude (43, 51%) lichen planus. After clinical follow-up and histopathologic review, most cases had persistent diagnostic discordance. Final clinical diagnoses were available in 70 women: lichen planus in 27 (38%), vulvodynia in 15 (21%), and the other 28 (40%) had LS (8), plasma cell vulvitis (5), psoriasis (4), dermatitis (4), candidosis (3), estrogen deficiency (3), and aphthosis (1). Histopathologic review highlighted the difficulty in distinguishing mucosa-associated lymphoid tissue from an inflammatory infiltrate in 23 (27%) of cases. Compared with other sites, biopsies from the mucocutaneous junction were more likely to be associated with a positive culture for Candida albicans. CONCLUSIONS: Nondiagnostic biopsies from the inner vulva should prompt thoughtful multidisciplinary review, but more research is required to resolve the problem of clinicopathologic discordance through better understanding of vulvar histology and pathophysiology.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171222
[Lr] Last revision date:171222
[St] Status:In-Process
[do] DOI:10.1097/LGT.0000000000000366

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[PMID]: 29158246
[Au] Autor:Barnes P; Vieira R; Harwood J; Chauhan M
[Ad] Address:New Croft Centre for Sexual Health, Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle upon Tyne.
[Ti] Title:Self-taken vaginal swabs versus clinician-taken for detection of candida and bacterial vaginosis: a case-control study in primary care.
[So] Source:Br J Gen Pract;, 2017 Nov 20.
[Is] ISSN:1478-5242
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Vaginal discharge and vulvitis are common presenting symptoms in general practice. Few studies have specifically looked at the validity of self-taken low vulvovaginal swabs (LVS) for the diagnosis of vulvovaginal candidiasis (VVC) and bacterial vaginosis (BV). AIM: To assess if patient self-taken LVS are a valid alternative to clinician-taken high vaginal swabs (HVS) for the detection of VVC and BV. DESIGN AND SETTING: Case-control study with the patient acting as their own control in an urban sexual health centre in Newcastle upon Tyne, UK. METHOD: Females aged 16-65 years attending with symptomatic vaginal discharge, vulval irritation, genital pain, and an offensive genital smell were recruited into the study. Participants took a self-taken LVS before vaginal examination, during which a clinician took an HVS (reference standard). Main outcome measures were the diagnosis of BV or VVC infection. RESULTS: A total of 104 females were enrolled. Of those, 45 were diagnosed with VVC and 26 with BV. The sensitivities of self-taken LVS for VVC and BV were 95.5% and 88.5% respectively. Cohen's κ coefficient showed 'strong agreement' for the detection of both VVC and BV. Vulval itching was the most common symptom associated with VVC (69%), whereas 50% of females diagnosed with BV presented with an offensive discharge. Both symptoms had poor positive predictive values (0.63 and 0.50, respectively). CONCLUSION: Self-taken LVS appears to be a valid alternative to clinician-taken HVS for detecting VVC and BV infections. Symptoms were found to be a poor indicator of underlying infection.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171121
[Lr] Last revision date:171121
[St] Status:Publisher

  4 / 731 MEDLINE  
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[PMID]: 28857965
[Au] Autor:Jaimes Suarez J; Vidal Conde L; Collazos Robles R; Grande Gomez J; Martin Díaz V; Parra Rodriguez O; Pérez-González YC
[Ad] Address:1Gynecology Department, Hospital San Rafael, Madrid, Spain, 2Soluciones Bioregenerativas SL, Barcelona, Spain; and 3Hospital Fundación Jiménez Díaz, Madrid, Spain.
[Ti] Title:Zoon Vulvitis Treated Successfully With Platelet-Rich Plasma: First Case Reported.
[So] Source:J Low Genit Tract Dis;21(4):e48-e51, 2017 10.
[Is] ISSN:1526-0976
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171018
[Lr] Last revision date:171018
[St] Status:In-Process
[do] DOI:10.1097/LGT.0000000000000330

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[PMID]: 28764581
[Au] Autor:Sand FL; Thomsen SF
[Ad] Address:a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
[Ti] Title:Skin diseases of the vulva: inflammatory, erosive-ulcerating and apocrine gland diseases, zinc and vitamin deficiency, vulvodynia and vestibulodynia.
[So] Source:J Obstet Gynaecol;:1-12, 2017 Aug 01.
[Is] ISSN:1364-6893
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Chronic, inflammatory and ulcerating mucocutaneous diseases that can affect the vulvar area are reviewed: lichen sclerosus, lichen planus, plasma cell vulvitis, complex aphthosis, Behcet's disease, pyoderma gangrenosum, metastatic Crohn's disease, dyskeratotic skin diseases (Hailey-Hailey disease and Darier's disease), autoimmune bullous diseases (mucous membrane pemphigoid and pemphigus vulgaris) and hidradenitis suppurativa. Also, vulvodynia and vestibulodynia, zinc and vitamin B deficiency are described.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170802
[Lr] Last revision date:170802
[St] Status:Publisher
[do] DOI:10.1080/01443615.2017.1328590

  6 / 731 MEDLINE  
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[PMID]: 28718897
[Au] Autor:Nguyen Y; Bradford J; Fischer G
[Ad] Address:Department of Dermatology, Kolling Institute, Northern Sydney Local Health District, Sydney, New South Wales, Australia.
[Ti] Title:Cyproterone acetate in the treatment of oestrogen hypersensitivity vulvovaginitis.
[So] Source:Australas J Dermatol;, 2017 Jul 18.
[Is] ISSN:1440-0960
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:Oestrogen hypersensitivity vulvovaginitis is a rare chronic cyclical vulvovaginitis responsive to oestrogen suppression or antagonism. We present a case series of 16 patients with refractory cyclical vulvovaginitis, all of whom responded to oestrogen suppression with cyproterone acetate.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170718
[Lr] Last revision date:170718
[St] Status:Publisher
[do] DOI:10.1111/ajd.12657

  7 / 731 MEDLINE  
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[PMID]: 28713513
[Au] Autor:Darabi R; Tadi S; Mohit M; Sadeghi E; Hatamizadeh G; Kardeh B; Etminan-Bakhsh M; Parsa Y
[Ad] Address:Department of Obstetrics and Gynecology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
[Ti] Title:The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women.
[So] Source:Electron Physician;9(5):4399-4404, 2017 May.
[Is] ISSN:2008-5842
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:BACKGROUND: Group B Streptococcus (GBS) is a leading cause of serious neonatal infections. Although great progress has been made in preventing prenatal GBS, its colonization rate in different regions of Iran remains unknown. AIM: To determine GBS colonization prevalence and its risk factors among Iranian pregnant women. METHODS: This prospective cross-sectional study was performed on 186 pregnant women, who attended Boo-Ali hospital which is affiliated with Islamic Azad University in Tehran, Iran, from March 2014 to June 2015. The demographic, obstetric and gynecological data were gathered. A recto-vaginal culture was taken from each patient, with a sterile swab, in lithotomy position without using speculum, and vaginal pH was measured. Patients with positive GBS received IV antibiotic therapy during labor (penicillin G 3 gram at first dose then 1.5 gram Q/4h until delivery). Data were analyzed by statistical software SPSS version 21. Statistical tests for differences were performed by Chi-square test. Potential confounding was assessed by logistic regression. Level of significance was set at p<0.05. RESULTS: Twenty-two (11.8%) patients had positive recto-vaginal colonization. No significant differences between colonized and GBS-negative women with regard to age, obstetrics history and socio-economic factor were noticed. In contrast, smoking, history of previous infection with HPV, presence of vulvitis and a vaginal pH>4.5 were associated with GBS colonization (p≤0.05). CONCLUSIONS: With a relatively low prevalence and few significantly correlated factors, it is hardly possible to define a high risk group of pregnant women for GBS colonization. Therefore, thorough measures should be taken in order to prevent infection complications in mothers and neonates in the Iranian population.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170719
[Lr] Last revision date:170719
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.19082/4399

  8 / 731 MEDLINE  
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[PMID]: 27786391
[Au] Autor:Baba Y; Umegaki-Arao N; Kimura Y
[Ad] Address:Department of Dermatology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
[Ti] Title:Successful treatment of intractable vulvitis circumscripta plasmacellularis via combination therapy with topical tacrolimus and tetracycline.
[So] Source:J Dermatol;44(10):1183-1185, 2017 Oct.
[Is] ISSN:1346-8138
[Cp] Country of publication:England
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1610
[Cu] Class update date: 171004
[Lr] Last revision date:171004
[St] Status:In-Data-Review
[do] DOI:10.1111/1346-8138.13672

  9 / 731 MEDLINE  
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[PMID]: 27687503
[Au] Autor:Donders GG; Sobel JD
[Ad] Address:Femicare Clinical Research for Women, Tienen, Belgium.
[Ti] Title:Candida vulvovaginitis: A store with a buttery and a show window.
[So] Source:Mycoses;60(2):70-72, 2017 Feb.
[Is] ISSN:1439-0507
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Although being an utterly frequent, non-mortal, yet distressing disease, and despite good knowledge of the pathogenesis and the availability of specific and safe treatment, vulvovaginal Candida (VVC) infection remains one of the most enigmatic problems for both physicians and patients. Good treatment requires a proper diagnosis. Too many caregivers (and patients treating themselves) react too simple-minded on the symptoms of VVC and treat VVC where they see it on the vulva. In this opinion paper, we plea for a thorough examination of women with VVC, especially in those women who suffer from recurrent disease since a long time, sometimes decades, which necessitates intensive examination of the vaginal flora, as this is invariably the reservoir for relapses and recurrent vulvitis. Examination of such complicated cases requires experienced clinical judgement, expertise bedside phase contrast microscopy of fresh vaginal fluid, classical cultures on Sabouroud medium and, if still unresolved, repetitive cultures taken by the patient herself at moments of symptoms, and/or nuclear acid amplification techniques to detect Candida genes in the vaginal fluid. Even if only vulvitis is evident, thorough expert examination of vaginal fluid is obligatory to diagnose VVC.
[Mh] MeSH terms primary: Candidiasis, Vulvovaginal/diagnosis
Candidiasis, Vulvovaginal/microbiology
Vagina/microbiology
Vulva/microbiology
[Mh] MeSH terms secundary: Antifungal Agents/therapeutic use
Candida/genetics
Candida/growth & development
Candida/isolation & purification
Candidiasis, Vulvovaginal/drug therapy
Female
Humans
Recurrence
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Nm] Name of substance:0 (Antifungal Agents)
[Em] Entry month:1703
[Cu] Class update date: 170323
[Lr] Last revision date:170323
[Js] Journal subset:IM
[Da] Date of entry for processing:161001
[St] Status:MEDLINE
[do] DOI:10.1111/myc.12572

  10 / 731 MEDLINE  
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[PMID]: 28090468
[Au] Autor:Lee YA; Chun P; Hwang EH; Mun SW; Lee YJ; Park JH
[Ad] Address:Good Gang-An Hospital, Busan, Korea.
[Ti] Title:Clinical Features and Extraintestinal Manifestations of Crohn Disease in Children.
[So] Source:Pediatr Gastroenterol Hepatol Nutr;19(4):236-242, 2016 Dec.
[Is] ISSN:2234-8646
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:PURPOSE: The aim of this study was to investigate the clinical features and extraintestinal manifestations (EIMs) of Crohn disease (CD) in Korean pediatric patients. METHODS: The medical records of 73 children diagnosed with CD were retrospectively reviewed. Data regarding baseline demographic and clinical characteristics, including CD phenotype at diagnosis based on the Montreal classification, and clinical features and course of EIMs were investigated. RESULTS: Fifty-two (71.2%) of the patients were males. The mean age of the patients was 12.5 years. The mean follow-up period was 3.4 years. The disease location was ileal in 3 (4.1%) of the patients, colonic in 13 (17.8%), ileocolonic in 56 (76.7%). The clinical behavior was inflammatory in 62 (84.9%) of the patients, stricturing in 8 (11.0%), and penetrating in 3 (4.1%). Perianal abscesses or fistulas were found in 37 (50.7%) of the patients. EIMs observed during the study period were anal skin tag in 25 patients (34.2%), hypertransaminasemia in 20 (27.4%), peripheral arthritis in 2 (2.7%), erythema nodosum in 2 (2.7%), vulvitis in 1 (1.4%), uveitis in 1 (1.4%), and pulmonary thromboembolism in 1 (1.4%). CONCLUSION: Perianal diseases and manifestations were present in more than half of Korean pediatric CD patients at diagnosis. Inspection of the anus should be mandatory in Korean children with suspicious CD, as perianal fistulas, abscesses, and anal skin tags may be the first clue to the diagnosis of CD.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1701
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5223/pghn.2016.19.4.236


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