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Search on : waterhouse-friderichsen and syndrome [Words]
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[PMID]: 29399828
[Au] Autor:Lin Z; Zhang L; Zhang D; Huo G; Zhou X; Yang YW; Huo Y; Li B; Geng XC
[Ad] Address:National Institute for Food and Drug Control, National Center for Safety Evaluation of Drugs, Beijing Key Lab for Pre-clinical Safety Evaluation of Drugs, Beijing, China.
[Ti] Title:A case report of spontaneous staphylococcal meningitis in a cynomolgus monkey.
[So] Source:J Med Primatol;47(2):132-135, 2018 Apr.
[Is] ISSN:1600-0684
[Cp] Country of publication:Denmark
[La] Language:eng
[Ab] Abstract:This report describes a suppurative meningitis in a young cynomolgus. The animal had neutrophil aggregation in the subarachnoid space and hemorrhage in bilateral adrenal glands. Staphylococcus was identified by FISH in brain. To our knowledge, this is the first case of staphylococcal meningitis with Waterhouse-Friderichsen syndrome in a cynomolgus monkey.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1802
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:In-Data-Review
[do] DOI:10.1111/jmp.12330

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[PMID]: 29247319
[Au] Autor:Houschyar KS; Rein S; Weissenberg K; Duscher D; Philipps HM; Nietzschmann I; Schulz T; Siemers F
[Ad] Address:Plastic and Reconstructive Surgery, BG Klinikum Bergmannstrost Halle, Merseburger Str.165, 06112, Halle, Deutschland. Khosrow-Houschyar@gmx.de.
[Ti] Title:Management einer schweren Sepsis unter Einsatz eines Zytokin-Adsorbers. [Management of severe sepsis using a Cytokin-adsorber].
[So] Source:Unfallchirurg;121(2):174-178, 2018 Feb.
[Is] ISSN:1433-044X
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:Based on a representative case, which was treated in our center for severe burn injuries, the severity of the Waterhouse-Friderichsen syndrome and the complexity of the prolonged course of treatment are illustrated. Special attention is focused on the new treatment paradigm using the CytoSorb® adsorber.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:In-Process
[do] DOI:10.1007/s00113-017-0450-y

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[PMID]: 28441232
[Au] Autor:Velghe D; Apers T; Devriendt S; Deblier I; Hendriks B; Nieuwendijk R; Rogiers P
[Ad] Address:1Department of Anesthesia and Reanimation, ZNA Middelheim Hospital, Antwerpen, Belgium.2Department of Cardiothoracic Surgery, ZNA Middelheim Hospital, Antwerpen, Belgium.3Department of Critical Care, ZNA Middelheim Hospital, Antwerpen, Belgium.
[Ti] Title:Atriobronchial Fistula Complicated by Septic Cerebral Air Emboli After Pulmonary Vein Ablation.
[So] Source:Crit Care Med;45(8):e867-e871, 2017 Aug.
[Is] ISSN:1530-0293
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To describe a case of an infected atriobronchial fistula as a late complication after pulmonary vein ablation, leading to septic air emboli and requiring urgent cardiac surgery. DATA SOURCES: Clinical observation. STUDY SELECTION: Case report. DATA EXTRACTION: Relevant clinical information. PubMed was searched for relevant literature. DATA SYNTHESIS: Given its high success and low complication rate, pulmonary vein isolation is expected to be increasingly performed worldwide. Despite its success, some of its rare complications are potentially devastating and are difficult to diagnose early. In this report, we present the case of a 32-year-old woman, who was readmitted to hospital 2 months after pulmonary vein ablation. The clinical picture resembled meningococcemia with spreading petechiae on legs and arms raising concern for Waterhouse-Friderichsen syndrome. Further echocardiographic investigation led to the discovery of massive amounts of intracardiac air which demanded urgent lung isolation and sternotomy. Intraoperatively a small infected left atrial perforation was oversewn and a fistula to the right main bronchus was closed by means of an autologous pericardial patch. One month later, still revalidating, she could be discharged home with only minor neurologic sequelae. CONCLUSIONS: Clinicians should be aware of the dramatic complications of invasive antiarrhythmic procedures and their atypical and late presentations. Better preprocedural appreciation of cardiac wall thickness, early echocardiographic diagnosis, and swift referral for cardiac surgery might impact outcome dramatically.
[Mh] MeSH terms primary: Bronchial Fistula/etiology
Catheter Ablation/adverse effects
Pulmonary Veins/surgery
Tachycardia, Ectopic Atrial/surgery
[Mh] MeSH terms secundary: Adult
Female
Humans
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:170426
[St] Status:MEDLINE
[do] DOI:10.1097/CCM.0000000000002438

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[PMID]: 28213751
[Au] Autor:Friedl C; Hackl G; Schilcher G; Rosenkranz AR; Eller K; Eller P
[Ad] Address:Department of Internal Medicine, Clinical Division of Nephrology, Medical University Graz, Graz, Austria.
[Ti] Title:Waterhouse-Friderichsen syndrome due to Neisseria meningitidis infection in a young adult with thrombotic microangiopathy and eculizumab treatment: case report and review of management.
[So] Source:Ann Hematol;96(5):879-880, 2017 May.
[Is] ISSN:1432-0584
[Cp] Country of publication:Germany
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1702
[Cu] Class update date: 170330
[Lr] Last revision date:170330
[St] Status:In-Data-Review
[do] DOI:10.1007/s00277-017-2951-8

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[PMID]: 28009598
[Au] Autor:Verzeletti A; Bonfanti C; Leide A; Azzalini E; De Francesco MA; Piccinelli G; De Ferrari F
[Ad] Address:From the *Forensic Medicine Unit, Section of Public Health and Human Sciences, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, and †Microbiology Section, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
[Ti] Title:Streptococcus Pneumoniae Detection Long Time After Death in a Fatal Case of Waterhouse-Friderichsen Syndrome.
[So] Source:Am J Forensic Med Pathol;38(1):18-20, 2017 Mar.
[Is] ISSN:1533-404X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We report a fatal case of Waterhouse-Friderichsen syndrome in a 64-year-old man. The diagnosis, suspected during the autopsy (performed 63 hours after death), was confirmed through the successful detection of Streptococcus pneumoniae DNA and antigens in samples (blood and liver) collected during the autopsy. These results conformed with blood cultures performed antemortem, which became available only the day after the autopsy. The case underlines the need to collect biological material (liver and blood samples) during autopsy for microbiological investigations, although the collection is performed a long time after the death, suggesting that a liver sample works for DNA and liver and blood work for Streptococcus pneumoniae antigen detection.
[Mh] MeSH terms primary: Pneumococcal Infections/complications
Streptococcus pneumoniae/isolation & purification
Waterhouse-Friderichsen Syndrome/diagnosis
[Mh] MeSH terms secundary: Adrenal Glands/pathology
DNA, Bacterial/isolation & purification
Fatal Outcome
Humans
Liver/microbiology
Male
Middle Aged
Splenectomy
Streptococcus pneumoniae/genetics
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA, Bacterial)
[Em] Entry month:1703
[Cu] Class update date: 170330
[Lr] Last revision date:170330
[Js] Journal subset:IM
[Da] Date of entry for processing:161224
[St] Status:MEDLINE
[do] DOI:10.1097/PAF.0000000000000284

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[PMID]: 27900398
[Au] Autor:El-Battrawy I; Ansari U; Behnes M; Kirschstein W; Britsch S; Jabbour C; Fastner C; Bill V; Borggrefe M; Akin I
[Ad] Address:I. Medizinische Klinik (Kardiologie, Angiologie, Pneumologie, Intensivmedizin und klinische Hämostaseologie), Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland. ibrahim.el-battrawy@umm.de.
[Ti] Title:Dyspnoe und Hautausschlag bei einem 49-jährigen Patienten. [Dyspnea and skin rash in a 49-year-old male patient].
[So] Source:Internist (Berl);58(3):282-286, 2017 Mar.
[Is] ISSN:1432-1289
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:We report on the case of a 49-year-old man who presented with increasing dyspnea and a skin rash. The community-acquired pneumonia was initially treated with broad spectrum antibiotics. The patient's respiratory condition rapidly worsened and the clinical picture of Waterhouse-Friderichsen syndrome developed with disseminated intravasal coagulopathy and necrosis of the toes. An infection with Capnocytophaga canimorsus, which had been caused by an initially unmentioned dog bite was confirmed. In view of the fulminant course and the high risk of operative treatment of the ubiquitous necroses in all limbs, a joint decision for deescalation of therapy was made together with relatives. The patient died 14 days after admission to hospital.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1612
[Cu] Class update date: 170916
[Lr] Last revision date:170916
[St] Status:In-Process
[do] DOI:10.1007/s00108-016-0162-3

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[PMID]: 27583208
[Au] Autor:Hale AJ; LaSalvia M; Kirby JE; Kimball A; Baden R
[Ad] Address:Division of Infectious Disease, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.
[Ti] Title:Fatal purpura fulminans and Waterhouse-Friderichsen syndrome from fulminant Streptococcus pneumoniae sepsis in an asplenic young adult.
[So] Source:IDCases;6:1-4, 2016.
[Is] ISSN:2214-2509
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Asplenic patients are at increased risk for sepsis and fulminant infection. Sepsis in these patients is typically secondary to encapsulated bacteria, with Streptococcus pneumoniae being the most frequent pathogen. Rare complications of severe sepsis include purpura fulminans and bilateral adrenal hemorrhage (Waterhouse-Friderichsen syndrome). We present the case of a 36-year-old woman, healthy except for splenectomy years prior for idiopathic thrombocytopenic purpura treatment, who presented with fever. Upon presentation to our hospital, three hours after symptoms onset, she had purpura fulminans and shock. Despite timely antimicrobials and maximal resuscitative efforts, her disease progressed and she expired 12 hours after symptoms onset. Autopsy revealed bilateral adrenal hemorrhage; acute adrenal crisis likely contributed to her refractory shock. Prior to her presentation, she had not received guideline-based post-splenectomy care. Sepsis in asplenic patients can be fulminant and rapidly fatal. Streptococcus pneumoniae remains the most frequent cause, despite decreasing rates in recent years related to widespread pneumococcal vaccination. Guideline-based vaccinations and "pill-in-pocket" therapy can be life-saving for asplenic patients. Purpura fulminans represents an extreme manifestation of disseminated intravascular coagulation, is more common in asplenic patients, and portends a poor prognosis. Waterhouse-Friderichsen syndrome can be seen concurrently with purpura fulminans and further portends a poor prognosis; pre-mortem diagnosis requires a high index of suspicion.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1609
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Da] Date of entry for processing:160902
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1016/j.idcr.2016.08.004

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[PMID]: 26942021
[Au] Autor:Emori K; Takeuchi N; Soneda J
[Ad] Address:Department of Cardiovascular Surgery, Kobe Tokusyukai Hospital, 1-3-10 Kamitakamaru, Tarumi-ku, Kobe-shi, Hyogo 655-0017, Japan.
[Ti] Title:A Case of Waterhouse-Friderichsen Syndrome Resulting from an Invasive Pneumococcal Infection in a Patient with a Hypoplastic Spleen.
[So] Source:Case Rep Crit Care;2016:4708086, 2016.
[Is] ISSN:2090-6420
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A 50-year-old male was brought to our emergency department by ambulance with complaints of pain and numbness in both legs. At arrival, purple spots were evident on his neck and face. Examination of the vital sign indicated septic shock. Laboratory data and blood gas analysis revealed disseminated intravascular coagulation, multiple organ failure, and metabolic acidosis. Peripheral blood smears revealed Howell-Jolly bodies, indicating decreased splenic function. A rapid urinary pneumococcal antigen test was also found to be positive. After admission to the intensive care unit, extensive treatment, including polymyxin-B direct hemoperfusion and administration of methylprednisolone and broad spectrum antibiotics was immediately initiated. Despite of our efforts to save his life, the patient died six hours after the arrival. The following day, blood cultures revealed the presence of Streptococcus pneumoniae. An autopsy revealed a hypoplastic spleen and a bilateral adrenal hemorrhage, indicating acute adrenal insufficiency caused by sepsis. Finally, the patient was diagnosed with Waterhouse-Friderichsen syndrome. Although severe infection may be seen in the splenectomized patients, it should be noted that patients with a hypoplastic spleen may have acute severe infections. We, therefore, report a case of Waterhouse-Friderichsen syndrome resulting from an invasive pneumococcal infection in a patient with a hypoplastic spleen.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Da] Date of entry for processing:160305
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2016/4708086

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[PMID]: 26261663
[Au] Autor:Hata Y; Chiba T; Ohtani M; Ishizawa S; Nishida N
[Ad] Address:Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama, Japan.
[Ti] Title:An autopsy case of pneumococcal Waterhouse-Friderichsen syndrome with possible functional asplenia/hyposplenia.
[So] Source:Int J Clin Exp Pathol;8(6):7518-25, 2015.
[Is] ISSN:1936-2625
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We report an autopsy case of rapid progressive Waterhouse-Friderichsen syndrome (WFS) associated with Streptococcus pneumonia infection in a previously healthy man. Although he once visited a hospital about 6 hours before death, the both physical and serological examination did not show any sign of overwhelming infection. Autopsy showed massive adrenal hemorrhage without inflammation, and showed proliferation of gram positive cocci and microthrombosis in the vessels of many organs. The pathological change of respiratory tract was extremely minimal. Size and weight of the spleen possible decreased than normal. However, histological examination showed that obscuration of germinal center and decreasing the immunological cells of mantle and marginal zone. Immunohisitochemically, marked decreasing the marginal zone macrophages, which are positive for specific intercellular adhesion molecule grabbing nonintegrin receptor-1 (SIGN-R1) and macrophage receptor with collagenous structure (MARCO), were decreased comparing with age-matched control case. Polymerase chain reaction (PCR) assay using each DNA, extraction from formalin-fixed paraffin-embedded specimen (FFPE) samples of lung, adrenal gland, heart, spleen, and kidney showed positive the ply gene and the lytA gene specific for Streptococcus pneumonia. Present case showed possible acquired atrophy of spleen, especially decreasing marginal zone macrophage may correlate with rapid progression of sepsis of Streptococcus pneumonia with massive adrenal hemorrhage. In addition, present case showed the usefulness of PCR using FFPE for the postmortem diagnosis of WFS.
[Mh] MeSH terms primary: Adrenal Glands/pathology
Pneumococcal Infections/pathology
Spleen/pathology
Streptococcus pneumoniae/isolation & purification
Waterhouse-Friderichsen Syndrome/pathology
[Mh] MeSH terms secundary: Adrenal Glands/microbiology
Atrophy
Autopsy
Biopsy
Cause of Death
Fatal Outcome
Humans
Immunohistochemistry
Male
Middle Aged
Organ Size
Pneumococcal Infections/microbiology
Spleen/chemistry
Spleen/microbiology
Waterhouse-Friderichsen Syndrome/microbiology
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1605
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Js] Journal subset:IM
[Da] Date of entry for processing:150812
[St] Status:MEDLINE

  10 / 305 MEDLINE  
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[PMID]: 25676131
[Au] Autor:Cooper JD; Dorion RP; Smith JL
[Ad] Address:Department of Internal Medicine, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA, 17822, USA. jdcooper@geisinger.edu.
[Ti] Title:A rare case of Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus in an immunocompetent patient.
[So] Source:Infection;43(5):599-602, 2015 Oct.
[Is] ISSN:1439-0973
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:A 53-year-old Caucasian male with hypertension and active tobacco abuse presented to a community hospital with a 2-day history of vague abdominal pain, myalgia and increased lethargy after being bitten on his right hand by the family dog while camping just 3 days prior to symptom onset. He expired within 90 min upon arrival to our intensive care unit. Pre-mortem blood cultures grew a fastidious Gram-negative aerobic rod that was identified as Capnocytophaga canimorsus. Autopsy findings showed multi-organ disseminated intravascular coagulopathy with microthrombi along with bilateral adrenal hemorrhage and necrosis of the adrenal glands consistent with Waterhouse-Friderichsen syndrome. This case contributes to the medical literature as a rare presentation of Capnocytophaga canimorsus infection in an otherwise immunocompetent patient and stresses the importance of a thorough history taking and physical examination by clinicians along with prompt administration of appropriate antibiotics.
[Mh] MeSH terms primary: Capnocytophaga/isolation & purification
Gram-Negative Bacterial Infections/complications
Gram-Negative Bacterial Infections/diagnosis
Waterhouse-Friderichsen Syndrome/etiology
Waterhouse-Friderichsen Syndrome/pathology
[Mh] MeSH terms secundary: Autopsy
Bites and Stings/complications
Fatal Outcome
Humans
Male
Middle Aged
Smoking
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 171113
[Lr] Last revision date:171113
[Js] Journal subset:IM
[Da] Date of entry for processing:150214
[St] Status:MEDLINE
[do] DOI:10.1007/s15010-015-0740-7


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