Database : MEDLINE
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  1 / 173 MEDLINE  
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[PMID]: 29477626
[Au] Autor:Tissandié L; Viciana S; Brevard H; Meierhenrich UJ; Filippi JJ
[Ad] Address:Institut de Chimie de Nice, Université Côte d'Azur, UMR 7272 CNRS, Parc Valrose, 06108 Nice Cedex 2, France.
[Ti] Title:Towards a complete characterisation of guaiacwood oil.
[So] Source:Phytochemistry;149:64-81, 2018 Feb 22.
[Is] ISSN:1873-3700
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Guaiacwood oil is a common perfume ingredient used in modern compositions for its suave woody-rosy scent. This essential oil is a byproduct of the timber industry obtained by hydrodistillation of the heartwood of Bulnesia sarmientoi, a tree native from Latin America. Despite being widely used in perfumery, guaiacwood oil has been poorly described in the past. This study aims at giving an in-depth characterisation of its chemical composition as well as disclosing the odorant compounds responsible for its characteristic fragrance. Our methodology was based on a combination of fractionation and analytical techniques, including comprehensive two-dimensional gas chromatography coupled to mass spectrometry and preparative capillary-gas chromatography. The entire analytical work led to the isolation of 20 constituents among which 14 have never been reported so far in natural extracts. Each isolated compound was fully characterised by spectroscopic methods. Finally, the accurate knowledge of the chemical composition permitted the identification of the odour-active constituents by gas chromatography-olfactometry.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180225
[Lr] Last revision date:180225
[St] Status:Publisher

  2 / 173 MEDLINE  
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[PMID]: 29177586
[Au] Autor:Kim HS; Lee JW; Jang H; Le TPL; Kim JG; Lee MS; Hong JT; Lee MK; Hwang BY
[Ad] Address:College of Pharmacy, Chungbuk National University, Cheongju, 28160, Korea.
[Ti] Title:Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells.
[So] Source:Arch Pharm Res;41(2):192-195, 2018 Feb.
[Is] ISSN:0253-6269
[Cp] Country of publication:Korea (South)
[La] Language:eng
[Ab] Abstract:A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1-6, 8-11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC values of 18.7-49.4 µM.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 180210
[Lr] Last revision date:180210
[St] Status:In-Process
[do] DOI:10.1007/s12272-017-0984-0

  3 / 173 MEDLINE  
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[PMID]: 29261340
[Au] Autor:GamalEl Din SF
[Ad] Address:a Kasr Alainy Faculty of Medicine, Andrology and STDs , Cairo University, Cairo , Egypt.
[Ti] Title:Role of Tribulus terrestris in Male Infertility: Is It Real or Fiction?
[So] Source:J Diet Suppl;:1-4, 2017 Dec 20.
[Is] ISSN:1939-022X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Tribulus terrestris is an annual herb of the Zygophyllaceae family and is commonly known as Gokshur, Gokharu, or puncturevine. Flavonoids, alkaloids, saponins, lignin, amides, and glycosides are the main active phytoconstituents of this plant. Infertility is defined by the failure to conceive a child after one year or more of regular unprotected sexual intercourse. Infertility affects society at large and has a negative impact on the social and emotional aspects of the patient. This in-depth review presents several studies that evaluate the role of Tribulus terrestris in a chronological order to help us better understand the exact mechanism by which this herbal medicine acts in male infertility. In conclusion, the exact role of Tribulus terrestris in male infertility is still controversial and needs future double-blind placebo-controlled studies that deploy larger cohorts.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171220
[Lr] Last revision date:171220
[St] Status:Publisher
[do] DOI:10.1080/19390211.2017.1402843

  4 / 173 MEDLINE  
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[PMID]: 29086839
[Au] Autor:Zhu W; Du Y; Meng H; Dong Y; Li L
[Ad] Address:School of Science, Beijing Technology and Business University, Beijing, 100048, People's Republic of China.
[Ti] Title:A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris.
[So] Source:Chem Cent J;11(1):60, 2017 Jul 11.
[Is] ISSN:1752-153X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a folk medicine for thousands of years in China, India, Sudan, and Pakistan. Numerous bioactive phytochemicals, such as saponins and flavonoids, have been isolated and identified from TT that are responsible alone or in combination for various pharmacological activities. This review provides a comprehensive overview of the traditional applications, phytochemistry, pharmacology and overuse of TT and provides evidence for better medicinal usage of TT.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1711
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/s13065-017-0289-x

  5 / 173 MEDLINE  
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[PMID]: 28857321
[Au] Autor:Alonso MR; Peralta I; Monti D; Martino R; Anesini C
[Ad] Address:Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
[Ti] Title:Stability of an Aqueous Extract of Larrea divaricata Cav. during a Simulated Digestion Process.
[So] Source:Phytother Res;31(11):1708-1714, 2017 Nov.
[Is] ISSN:1099-1573
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Larrea divaricata Cav. (Zygophyllaceae) is a South American plant widely distributed in Argentina that is used in folk medicine to treat inflammatory diseases. The aqueous extract is known to have well-documented biological activities such as antitumour, immunomodulatory, antimicrobial, antiinflammatory and antioxidant. However, its stability in gastrointestinal fluids is unknown. The latter is an important factor to assure the bioavailability of plant extracts intended to be administered via the oral route. The aim of this work was to study the stability of a lyophilized aqueous extract of L. divaricata compressed as a pill. To this end, the main polyphenol compound found in the extract, that is, the nordihydroguaiaretic acid, the total polyphenols and flavonoids content and the antioxidant activity such as diphenylpicrylhydrazyl scavenger activity and reducing power were assayed after subjecting the extract to different incubation times in simulated digestive fluids. The HPLC and spectroscopic methods were employed. Although the levels of polyphenols and flavonoids decreased upon incubation in gastric and intestinal fluids, the extract maintained its antioxidant activity related to the presence of nordihydroguaiaretic acid. These results are promising and encourage the potential use of the extract by the oral route as a supplement or phytomedicine with antioxidant activity. Copyright © 2017 John Wiley & Sons, Ltd.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[St] Status:In-Process
[do] DOI:10.1002/ptr.5897

  6 / 173 MEDLINE  
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[PMID]: 28813688
[Au] Autor:Kanwal N; Adhikari A; Hameed A; Hafizur RM; Musharraf SG
[Ad] Address:H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
[Ti] Title:Isolation and characterization of non-sulfated and sulfated triterpenoid saponins from Fagonia indica.
[So] Source:Phytochemistry;143:151-159, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Seven previously undescribed, sulfated triterpenoid glycosides, named nayabin A-G along with a known triterpenoid glycoside were isolated from the whole plant of Fagonia indica. Their structures were elucidated through spectral studies including 1D- ( H and C), 2D-NMR spectroscopy (HSQC, HMBC, COSY and NOESY), and mass spectrometry (ESI-MS/MS). ß-D-Glucopyranosyl 3ß-hydroxy-23-O-ß-D-glucopyranosyloxy-taraxast-20-en-28-oate, a known compound exerts glucose-dependent insulin secretory activity, which seems to exhibit a decreased risk of drug-induced hypoglycemia and may offer distinct advantages as anti-diabetic agent.
[Mh] MeSH terms primary: Zygophyllaceae/chemistry
[Mh] MeSH terms secundary: Glycosides
Insulin/pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pakistan
Saponins/chemistry
Tandem Mass Spectrometry
Triterpenes/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Glycosides); 0 (Insulin); 0 (Saponins); 0 (Triterpenes)
[Em] Entry month:1710
[Cu] Class update date: 171002
[Lr] Last revision date:171002
[Js] Journal subset:IM
[Da] Date of entry for processing:170817
[St] Status:MEDLINE

  7 / 173 MEDLINE  
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[PMID]: 28724331
[Au] Autor:Rashad H; Metwally FM; Ezzat SM; Salama MM; Hasheesh A; Abdel Motaal A
[Ad] Address:a Department of Environmental and Occupational Medicine , National Research Center , Dokki , Egypt.
[Ti] Title:Randomized double-blinded pilot clinical study of the antidiabetic activity of Balanites aegyptiaca and UPLC-ESI-MS/MS identification of its metabolites.
[So] Source:Pharm Biol;55(1):1954-1961, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: Balanites aegyptiaca Del. (Zygophyllaceae) fruits are traditionally known for the treatment of hyperglycaemia. Several in vitro and in vivo studies proposed some mechanisms of action. However, clinical trials in human beings were never reported to date. OBJECTIVES: To investigate the antidiabetic efficacy of the 70% ethanol extract of the pericarps of B. aegyptiaca (BE) within a nutritional intervention in elderly people. MATERIALS AND METHODS: Ultra-performance electrospray ionization-mass spectroscopy (UPLC-ESI-MS/MS) analysis was used for metabolic profiling of BE which was incorporated in hard gelatine capsules (400 mg/day) and tested on 30 type 2 diabetes (T2D) Egyptian patients for 8 weeks. According to sex, age and body mass index participants were divided into two equivalent groups, placebo and treatment. RESULTS: Thirteen compounds were identified in BE using UPLC-ESI-MS/MS analysis among which five steroidal saponins, seven phenolic compounds and a sterol glucoside. At the end of the 8-week treatment, the treated group showed 26.88% decrease in 2 h postprandial plasma glucose relative to 2.6% increase in the placebo group, while fasting plasma glucose was reduced to 10.3%. Treatment with BE capsules for 8 weeks produced significant reduction in the plasma triglyceride, total cholesterol and low-density lipoprotein cholesterol by 9.0, 12.76 and 21.35%, respectively, with 29.8% increase in the high-density lipoprotein cholesterol. Plasma alanine transaminase and aspartate transaminase were reduced by 42.6 and 43.3%, respectively. DISCUSSION AND CONCLUSION: Administration of the BE capsules to T2D resulted in significant improvements in the glycaemic markers and the lipid profile, without adverse effects or hypoglycaemia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170720
[Lr] Last revision date:170720
[St] Status:In-Process
[do] DOI:10.1080/13880209.2017.1354388

  8 / 173 MEDLINE  
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[PMID]: 28702596
[Au] Autor:Zhang M; Ma J; Bi H; Song J; Yang H; Xia Z; Du Y; Gao T; Wei L
[Ad] Address:Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China. bihongtao@hotmail.com lxwei@nwipb.cas.cn.
[Ti] Title:Characterization and cardioprotective activity of anthocyanins from Nitraria tangutorum Bobr. by-products.
[So] Source:Food Funct;8(8):2771-2782, 2017 Aug 01.
[Is] ISSN:2042-650X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The Nitraria tangutorum Bobr. fruit is an indigenous berry of the shrub belonging to the Zygophyllaceae family which grows at an altitude of over 3000 m in the Tibetan Plateau, and has been used as a native medicinal food for treating weakness of the spleen, stomach syndrome, dyspepsia, neurasthenia, dizziness, etc. for thousands of years. Nowadays, N. tangutorum industrial juice by-products generated from health food production can be a potential low cost source of some unique bioactive ingredients. In a prior study, we established a simultaneous microwave/ultrasonic assisted enzymatic extraction method for extracting antioxidant ingredients from the industrial by-products of N. tangutorum juice. In this study, these ingredients were selectively fractionated by cation-exchange resin chromatography to obtain an anthocyanin fraction namely NJBAE. NJBAE was found to be composed of 16 anthocyanins derived from six anthocyanidins by HPLC-ESI-MS, and has an appreciable cardioprotective effect on doxorubicin-induced injured H9c2 cardiomyocytes. The cardioprotective mechanism research showed that NJBAE could directly scavenge ROS, restrict further generation of ROS, promote the activity of key antioxidase, enhance glutathione redox cycling, then affect the apoptotic signaling changes in a positive way, and finally mediate caspase-dependent cell death pathways. Therefore, NJBAE has great potential to be used for preventing and treating cardiovascular disease in the food, pharmaceutical and other emerging industries.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:In-Process
[do] DOI:10.1039/c7fo00569e

  9 / 173 MEDLINE  
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[PMID]: 28659002
[Au] Autor:Ezzat SM; Abdel Motaal A; El Awdan SAW
[Ad] Address:a Department of Pharmacognosy, Faculty of Pharmacy , Cairo University , Cairo , Egypt.
[Ti] Title:In vitro and in vivo antidiabetic potential of extracts and a furostanol saponin from Balanites aegyptiaca.
[So] Source:Pharm Biol;55(1):1931-1936, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:CONTEXT: Balanites aegyptiaca Del. (Zygophyllaceae) fruits are well-known antidiabetic drug in Egyptian folk medicine. Nevertheless, its mechanism of action is still unclear. OBJECTIVES: Searching for the possible mechanisms of action of the plant and identification of its bioactive compounds. MATERIALS AND METHODS: A bio-guided protocol based on the evaluation of α-glucosidase (AG) and aldose reductase (AR) inhibitory activities was adopted to isolate the biologically active compounds from the methanol extract (MeEx). An in vivo antidiabetic study was conducted for the active extract, fraction and compound using streptozotocin-induced diabetic male albino Wistar rats at two dose levels (100 and 200 mg/kg.b/wt) for 2 weeks. RESULTS: Three compounds were isolated and identified: a sterol, (1) stigmasterol-3-O-ß-d-glucopyranoside; a pregnane glucoside, (2) pregn-5-ene-3ß,16ß,20(R)-trio1-3-O-ß-d-glucopyranoside; a furostanol saponin, (3) 26-(O-ß-d-glucopyranosyl)-22-O-methylfurost-5-ene-3ß,26-diol-3-O-ß-d-glucopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-ß-d-glucopyranoside. Only compound 3 possessed significant AG and AR inhibitory activities (IC = 3.12 ± 0.17 and 1.04 ± 0.02 µg/mL, respectively), while compounds 1 and 2 were inactive. The in vivo antidiabetic study revealed that MeEx and furostanol saponin 3 possessed significant activities at a dose of 200 mg/kg through reducing the fasting plasma glucose level by 46.14% and 51.39%, respectively, as well as reducing the total cholesterol by 24.44% and 31.90%, respectively. Compound 3 also caused increment in insulin and C-peptide levels by 63.56% and 65%, respectively. DISCUSSION AND CONCLUSIONS: We presented a scientific base for using Balanites aegyptiaca, and shed the light on one of its saponins, as an antidiabetic agent in fasting and postprandial hyperglycaemia along with the improvement of diabetic complications.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170629
[Lr] Last revision date:170629
[St] Status:In-Process
[do] DOI:10.1080/13880209.2017.1343358

  10 / 173 MEDLINE  
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[PMID]: 28653912
[Au] Autor:Shad AA; Zakirudin -; Bakht J; Jan S
[Ad] Address:Department of Agricultural Chemistry, The University of Agriculture Peshawar, KPK Pakistan.
[Ti] Title:Antimicrobial, antioxidant potential and phytochemical screening of Fagonia olivieri.
[So] Source:Pak J Pharm Sci;30(3):697-703, 2017 May.
[Is] ISSN:1011-601X
[Cp] Country of publication:Pakistan
[La] Language:eng
[Ab] Abstract:The present paper investigates antioxidant, antimicrobial and photochemical screening different extracts of Fagonia olivieri. Analysis of the data indicated that the subject plant contained a good amount of flavonoids, tannins, saponins, terpenoids and steroids. Maximum concentrations of phenolic compounds was found in methanol fraction (29.0±6.12 mg GAE/g) while minimum (22.10±6.31mg GAE/g) in methylated spirit fraction. Similarly, ethanol fraction contained higher concentration of flavonoid content (135.4±7.63mg Quercetin/g) followed by methanol fraction (138.4±2.96 mg Quercetin/g). Analysis of the data revealed that maximum antioxidant activity was recorded in mthylated spirit fraction (IC = 10.69±1.66) followed by methanol fraction (IC = 9.10±0.76) while no activity was noted in hexane fraction. The data indicated good antibacterial and antifungal activity against S. typhi, S. aureus, P. aeruginosa and A. flavus.
[Mh] MeSH terms primary: Anti-Infective Agents/pharmacology
Antioxidants/pharmacology
Plant Extracts/pharmacology
Zygophyllaceae/chemistry
[Mh] MeSH terms secundary: Microbial Sensitivity Tests
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Entry month:1709
[Cu] Class update date: 170907
[Lr] Last revision date:170907
[Js] Journal subset:IM
[Da] Date of entry for processing:170628
[St] Status:MEDLINE


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