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Pesquisa : Camellia [Palavras]
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  1 / 3217 MEDLINE  
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[PMID]:29524277
[Au] Autor:de Vries HJC; Soltanipoor M; Kezic S; Vergunst CE
[Ad] Endereço:Department of Dermatology, Academic Medical Center University of Amsterdam, Meibergdreef, 91105 AZ, Amsterdam, The Netherlands.
[Ti] Título:Sinecatechins ointment 10% (Veregen ) for genital warts: percutaneous penetration of Epigallocatechin Gallate concentrations in the stratum corneum collected by adhesive tape stripping method.
[So] Source:J Eur Acad Dermatol Venereol;, 2018 Mar 10.
[Is] ISSN:1468-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Camellia sinensis extract/Sinecatechins/10% ointment is a registered topical therapy for the treatment of external and perianal genital warts, to be applied thrice daily. Pharmacokinetic studies elucidating the most optimal frequency of application have not been undertaken, and a less frequent (more convenient) application schedule might also be effective. Here, we measured epigallocatechin gallate (EGCG) concentrations, the main Camellia sinensis extract component, in the stratum corneum (SC) over time after one application. This article is protected by copyright. All rights reserved.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180310
[Lr] Data última revisão:
180310
[St] Status:Publisher
[do] DOI:10.1111/jdv.14933


  2 / 3217 MEDLINE  
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[PMID]:29523107
[Au] Autor:Rani R; Arora S; Kaur J; Manhas RK
[Ad] Endereço:Department of Microbiology, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
[Ti] Título:Phenolic compounds as antioxidants and chemopreventive drugs from Streptomyces cellulosae strain TES17 isolated from rhizosphere of Camellia sinensis.
[So] Source:BMC Complement Altern Med;18(1):82, 2018 Mar 09.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Oxidative stress in an intracellular environment created by the accumulation of reactive oxygen species results in oxidative damage to biomolecules which ultimately become a hallmark for severe diseases like cancer, aging, diabetes, and cardiovascular and neurodegenerative diseases. METHODS: Various in vitro assays were employed to assess the antioxidant potential of strain, DNA protective activity was demonstrated using DNA nicking assay and cytotoxicity of the extract was evaluated using MTT assay. Further identification of the compounds was done using UPLC analysis. RESULTS: The extract of Streptomyces cellulosae strain TES17 demonstrated significant antioxidant activity with percentage inhibition of 78.47 ± 0.23, 91.08 ± 0.98 and 82.08 ± 0.93 for DPPH, ABTS and superoxide radical assays at 5 mg/mL, respectively. Total antioxidant and reducing power were found to be 76.93 ± 0.76 and 231.96 ± 0.51 mg AAE/100 mg of dry extract, respectively. Moreover, the extract was shown to inhibit lipid peroxidation upto 67.18 ± 1.9% at 5 mg/mL. TPC and TFC measured in the extract was 55 mg GAE/100 mg and 11.17 ± 4.05 mg rutin/100 mg, respectively. The protective nature of the TES17 extract to oxidative stress induced damaged DNA was shown by percentage of supercoiled DNA i.e. Form I was increased from 26.38 to 38.20% at concentrations ranging from 2 µg to 10 µg. TES17 extract also showed the cytotoxic activity against lung cancer cell line with 74.7 ± 1.33% inhibition whereas, limited toxicity was observed against normal cell line with percentage viability of 87.71 ± 6.66 at same concentration (30 µg/mL) tested. The antioxidant capacity of extract was well correlated with its TPC and TFC and this in turn was in keeping with the UPLC analysis which also revealed the presence of phenolic compounds that were responsible for the antioxidant and cytotoxic potential of S. cellulosae strain TES17. CONCLUSIONS: The present study describes that S. cellulosae strain TES17 isolated from the rhizosphere of Camellia sinensis (tea) plant; produces potent compounds with antioxidant activity, further might be developed into therapeutic drugs to combat oxidative stress.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180310
[Lr] Data última revisão:
180310
[St] Status:In-Process
[do] DOI:10.1186/s12906-018-2154-4


  3 / 3217 MEDLINE  
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[PMID]:29500448
[Au] Autor:Wang YX; Liu ZW; Wu ZJ; Li H; Wang WL; Cui X; Zhuang J
[Ad] Endereço:Tea Science Research Institute, College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.
[Ti] Título:Genome-wide identification and expression analysis of GRAS family transcription factors in tea plant (Camellia sinensis).
[So] Source:Sci Rep;8(1):3949, 2018 Mar 02.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:GRAS proteins are important transcription factors that play multifarious roles in regulating the growth and development as well as stress responses of plants. Tea plant is an economically important leaf -type beverage crop. Information concerning GRAS family transcription factors in tea plant is insufficient. In this study, 52 CsGRAS genes encoding GRAS proteins were identified from tea plant genome database. Phylogenetic analysis of the identified GRAS proteins from tea plant, Arabidopsis, and rice divided these proteins into at least 13 subgroups. Conserved motif analysis revealed that the gene structure and motif compositions of the proteins were considerably conserved among the same subgroup. Functional divergence analysis indicated that the shifted evolutionary rate might act as a major evolutionary force driving subfamily-specific functional diversification. Transcriptome analysis showed that the transcriptional levels of CsGRAS genes under non-stress conditions varied among different tea plant cultivars. qRT-PCR analysis revealed tissue and development stage-specific expression patterns of CsGRAS genes in tea plant. The expression patterns of CsGRAS genes in response to abiotic stresses and gibberellin treatment suggested the possible multiple functions of these genes. This study provides insights into the potential functions of GRAS genes.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-22275-z


  4 / 3217 MEDLINE  
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[PMID]:29484370
[Au] Autor:Hou X; Du H; Yang R; Qi J; Huang Y; Feng S; Wu Y; Lin S; Liu Z; Jia AQ; Yuan S; Sun L
[Ad] Endereço:Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China.
[Ti] Título:The antitumor activity screening of chemical constituents from Camellia nitidissima Chi.
[So] Source:Int J Mol Med;41(5):2793-2801, 2018 May.
[Is] ISSN:1791-244X
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Chemotherapy is the preferred and most common treatment for cancer in clinical practice. An increasing number of researchers all over the world are focusing on natural medicines to find new antitumor drugs, and several reports have shown that Camellia nitidissima (C. nitidissima) Chi could reduce blood-lipid, decrease blood pressure, resist oxidation, prevent carcinogenesis and inhibit tumors. Therefore, the pharmacodynamics of the chemical constituents in C. nitidissima need to be investigated further. In the present study, 16 chemical constituents were isolated from the leaves of C. nitidissima, of which 6 compounds are reported to be found in this plant for the first time. Furthermore, all these phytochemicals were screened for antitumor activity on 4 common cancer cell lines, while compound 3, one oleanane-type triterpene, exhibited the most potential antitumor effects. Interestingly, to our knowledge, this was the first report that compound 3 inhibits cancer cells. Compound 3 inhibited EGFR-mutant lung cancer cell line, NCI-H1975 via apoptosis effect, with an IC50 of 13.37±2.05 µM at 48 h. Based on the data, compound 3 showed potential for antitumor drug development, suggesting the scientific basis for the antitumor activity of C. nitidissima.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[St] Status:In-Process
[do] DOI:10.3892/ijmm.2018.3502


  5 / 3217 MEDLINE  
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[PMID]:29504372
[Au] Autor:Hafiz I; Bhatti HN; Hanif MA; Shahid M
[Ad] Endereço:Department of Chemistry, University of Agriculture, Faisalabad, Pakistan.
[Ti] Título:In-vitro antibacterial and antioxidant potential of winged prickly ash, green tea and thyme.
[So] Source:J Biol Regul Homeost Agents;32(1):101-106, 2018 Jan-Feb.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Herbs and plants are mostly used as antimicrobials and antioxidants owing to the harmfulness and linked side-effects of synthetic chemical constituents. Plants and spices produce various metabolites with antibacterial and antioxidant potential. These metabolites are principally revealed as encouraging healing components or mediators which control ailments in human beings. The present study was aimed to characterize the extracts from selected medicinal plants through in-vitro activities. Winged prickly ash, green tea and thyme were selected and extracted through ethanol and methanol solutions. The extracts were assessed for antibacterial and antioxidant activities. The antibacterial potential of extracts showed the significant extent of the activity against Bacillus subtilis and E. coli. The maximum activity was noted in 80% methanolic fraction of Thymus vulgaris (15.20±0.64 mm) against Bacillus subtilis. Antioxidant potential exhibited the highest phenolic and flavonoid content in Camellia sinensis . The total phenolic content was significantly higher (1456.26±12.05 mg gallic acid) in 80% ethanolic fraction of Camellia sinensis. The flavonoid content in different plant extracts ranged from 8.17±2.02 to 376.29±7.11 mg/g. The radical scavenging DPPH assay also showed the significant antioxidant capacity of selected plants with the methanolic (50%) extract of Camellia sinensis found to be the most potent (78.95±7.12%). It was concluded that the alcoholic extracts of selected medicinal plants revealed the effective antibacterial and antioxidant activity, showing protective prospective against oxidative injury.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[St] Status:In-Data-Review


  6 / 3217 MEDLINE  
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[PMID]:29500570
[Au] Autor:Zhang S; Shen P; Li M; Tian X; Zhou C; Cao M
[Ad] Endereço:National Citrus Engineering Research Center, Citrus Research Institute, Southwest University, Chongqing, 400712, China.
[Ti] Título:Discovery of a novel geminivirus associated with camellia chlorotic dwarf disease.
[So] Source:Arch Virol;, 2018 Mar 02.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Next-generation sequencing of small RNAs and PCR amplification with two pairs of back-to-back primers, followed by cloning and sequencing, allowed identification of a novel geminivirus isolate provisionally named camellia chlorotic dwarf-associated virus (CaCDaV). The complete genome sequence of CaCDaV comprises 3,687 nucleotides (nts) and six open reading frames (ORFs). The genome and putative proteins of CaCDaV were most closely related to those of two unclassified geminiviruses: citrus chlorotic dwarf-associated virus (CCDaV, 3,640 nt) and mulberry mosaic dwarf-associated virus (MMDaV, 2,952 nt). Phylogenetic analysis revealed a distinct clade for CaCDaV, CCDaV and MMDaV, supporting their inclusion in a new genus within the family Geminiviridae. Because CaCDaV and CCDaV shared a high genome nucleotide sequence identity (54.8%), we propose that the CaCDaV should be included as a member in this new genus.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180303
[Lr] Data última revisão:
180303
[St] Status:Publisher
[do] DOI:10.1007/s00705-018-3780-3


  7 / 3217 MEDLINE  
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[PMID]:29495365
[Au] Autor:Koch W; Kukula-Koch W; Komsta L
[Ad] Endereço:Chair and Department of Food and Nutrition, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, Poland. kochw@interia.pl.
[Ti] Título:Black Tea Samples Origin Discrimination Using Analytical Investigations of Secondary Metabolites, Antiradical Scavenging Activity and Chemometric Approach.
[So] Source:Molecules;23(3), 2018 Feb 26.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A comprehensive study on the composition and antioxidant properties of black tea samples with a chemometric approach was performed via LC-ESI-Q-TOF-MS, DPPH radical scavenging assay, and Folin-Ciocalteu assay (TPC). Marked differences between the teas from seven different countries (China, India, Iran, Japan, Kenya, Nepal, Sri Lanka) were shown. The Indian samples demonstrated the highest total catechin content (184.8 mg/100 mL), the largest TPC and DPPH scavenging potential (58.2 mg/100 mL and 84.5%, respectively). The applied principal component analysis (PCA) and ANOVA revealed several correlations between the level of catechins in tea infusions. EC (epicatechin), ECG (epicatechin gallate), EGC (epigallocatechin), and EGCG (epigallocatechin-3-gallate) content was not correlated with DPPH, gallic acid, and TPC; however, a strong correlation of EC and ECG between themselves and a negative correlation of these two catechins with EGCG and EGC was noted. Interestingly, simple catechins were not found to be responsible for antioxidant properties of the black teas. The samples collected in the higher altitudes were similar.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[St] Status:In-Process


  8 / 3217 MEDLINE  
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[PMID]:29486662
[Au] Autor:Tfouni SAV; Reis RM; Kamikata K; Gomes FML; Morgano MA; Furlani RPZ
[Ti] Título:Polycyclic aromatic hydrocarbons in teas using QuEChERS and HPLC-FLD.
[So] Source:Food Addit Contam Part B Surveill;, 2018 Feb 28.
[Is] ISSN:1939-3229
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Polycyclic aromatic hydrocarbons (PAHs) are food processing contaminants considered to be carcinogenic and genotoxic. Due to its drying process stage, teas may be contaminated with PAHs. The aim of the study was to validate an analytical method involving QuEChERS and HPLC-FLD for determination of PAH4 in teas and evaluate the contamination levels in 10 different types of teas from Brazil. Recoveries varied from 54-99% and RSDs from 1-21%. LODs and LOQs were from 0.03 to 0.3 µg/kg and 0.1 to 0.5 µg/kg, respectively. Mate tea presented the highest PAH levels, with PAH4 varying from 194 to 1795 µg/kg; followed by black (1.8 to 186 µg/kg), white (24 to 119 µg/kg) and green tea (3.1 to 92 µg/kg). Teas with lowest PAH4 were: strawberry, lemongrass, peppermint and boldo. Only trace levels of PAHs were detected in tea infusions, so apparently it would not affect PAHs intake by Brazilian population.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[St] Status:Publisher
[do] DOI:10.1080/19393210.2018.1440638


  9 / 3217 MEDLINE  
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[PMID]:29429331
[Au] Autor:Hu JN; Shen JR; Xiong CY; Zhu XM; Deng ZY
[Ad] Endereço:School of Food Science and Technology, Dalian Polytechnic University , Dalian 116034, China.
[Ti] Título:Investigation of Lipid Metabolism by a New Structured Lipid with Medium- and Long-Chain Triacylglycerols from Cinnamomum camphora Seed Oil in Healthy C57BL/6J Mice.
[So] Source:J Agric Food Chem;66(8):1990-1998, 2018 Feb 28.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the present study, a new structured lipid with medium- and long-chain triacylglycerols (MLCTs) was synthesized from camellia oil (CO) and Cinnamomum camphora seed oil (CCSO) by enzymatic interesterification. Meanwhile, the antiobesity effects of structured lipid were investigated through observing the changes of enzymes related to lipid mobilization in healthy C57BL/6J mice. Results showed that after synthesis, the major triacylgeride (TAG) species of intesterificated product changed to LaCC/CLaC (12.6 ± 0.46%), LaCO/LCL (21.7 ± 0.76%), CCO/LaCL (14.2 ± 0.55%), COO/OCO (10.8 ± 0.43%), and OOO (18.6 ± 0.64%). Through second-stage molecular distillation, the purity of interesterified product (MLCT) achieved 95.6%. Later, male C57BL/6J mice were applied to study whether the new structured lipid with MLCT has the efficacy of preventing the formation of obesity or not. After feeding with different diets for 6 weeks, MLCTs could reduce body weight and fat deposition in adipose tissue, lower plasma triacylglycerols (TG) (0.89 ± 0.16 mmol/L), plasma total cholesterol (TC) (4.03 ± 0.08 mmol/L), and hepatic lipids (382 ± 34.2 mg/mice) by 28.8%, 16.0%, and 30.5%, respectively, when compared to the control 2 group. This was also accompanied by increasing fecal lipids (113%) and the level of enzymes including cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), hormone-sensitive lipase (HSL), and adipose triglyceride lipase (ATGL) related to lipid mobilization in MLCT group. From the results, it can be concluded that MLCT reduced body fat deposition probably by modulating enzymes related to lipid mobilization in C57BL/6J mice.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[St] Status:In-Process
[do] DOI:10.1021/acs.jafc.7b05659


  10 / 3217 MEDLINE  
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[PMID]:29409322
[Au] Autor:Ji HG; Lee YR; Lee MS; Hwang KH; Park CY; Kim EH; Park JS; Hong YS
[Ad] Endereço:Division of Food and Nutrition, Chonnam National University , Yongbong-ro, Buk-gu, Gwangju 500-757, Republic of Korea.
[Ti] Título:Diverse Metabolite Variations in Tea (Camellia sinensis L.) Leaves Grown Under Various Shade Conditions Revisited: A Metabolomics Study.
[So] Source:J Agric Food Chem;66(8):1889-1897, 2018 Feb 28.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:With the increase of tea (Camellia sinensis) consumption, its chemical or metabolite compositions play a crucial role in the determination of tea quality. In general, metabolite compositions of fresh tea leaves including shoots depend on plucking seasons and tea cultivators. Therefore, choosing a specific plucking time of tea leaves can provide use-specified tea products. Artificial control of tea growing, typically shade treatments, can lead to significant changes of the tea metabolite compositions. However, metabolic characteristics of tea grown under various shade treatment conditions remain unclear. Therefore, the objective of the current study was to explore effects of various shade conditions on metabolite compositions of tea through a H NMR-based metabolomics approach. It was noteworthy that the levels of catechins and their derivatives were only influenced at the initial time of shade treatments while most amino acids were upregulated as amounts of shade and periods were increased: that is, the levels of alanine, asparagine, aspartate, isoleucine, threonine, leucine, and valine in fresh tea leaves were conspicuously elevated when shade levels were raised from 90% to 100% and when period of shade treatments was increased by 20 days. Such increased synthesis of amino acids along with large reductions of glucose level reflected carbon starvation under the dark conditions, indicating remarkable proteolysis in the chloroplast of tea leaves. This study provides important information about making amino acid-enhanced tea products based on global characteristics of diverse tea leaf metabolites induced by various shade treatment conditions.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[St] Status:In-Process
[do] DOI:10.1021/acs.jafc.7b04768



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