Base de dados : MEDLINE
Pesquisa : Cicatriz and Hipertrófica [Palavras]
Referências encontradas : 1766 [refinar]
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[PMID]:29069016
[Au] Autor:Wang X; Wu X; Liu K; Xia L; Lin X; Liu W; Gao Z
[Ad] Endereço:aDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine bShanghai Key Laboratory of Tissue Engineering, Shanghai, China.
[Ti] Título:Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids.
[So] Source:Medicine (Baltimore);96(43):e8353, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intralesional steroid injections are the standard treatment for hypertrophic scars and keloids. The procedure is, however, quite painful and is unpopular with patients because of this. Topical application of anesthetic creams, such as Ametop gel (tetracaine) and EMLA cream (lidocaine and prilocaine), has limited efficacy because of poor drug penetration. The onset of the analgesic effect is also slow, which means that the use of topical anesthetics is time-consuming in clinical practice.We hypothesized that a commercially available cryotip could be used to provide fast-acting topical cryoanesthesia that would reduce the pain associated with steroid injections.Thirty patients with hypertrophic scars or keloids were enrolled in the study. Scars were injected with the steroid, triamcinolone acetonide, with or without prior application of the cryotip (-10 °C) for 15 seconds. The degree of pain was evaluated in each case using the visual analogue scale (VAS) and the verbal descriptor scale (VDS), together with any side-effects caused by application of the cryotip.The VAS pain scores showed a statistically significant (P < .01) difference between the pretreated and the control scars (pain scores 7.87 ±â€Š1.31 and 2.7 ±â€Š1.37, respectively). The VDS pain scores also showed a statistically significant (P < .01) difference between the pretreated and the control scars. And its average scores were 7.89 ±â€Š0.32 and 2.68 ±â€Š0.25, respectively.Application of the cryotip before injection could provide a rapid and effective means of reducing the pain associated with steroid injections. Painless would result in better therapeutic effect.
[Mh] Termos MeSH primário: Anestésicos Locais/administração & dosagem
Crioanestesia/instrumentação
Glucocorticoides/administração & dosagem
Dor/quimioterapia
Triancinolona Acetonida/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Cicatriz Hipertrófica/quimioterapia
Crioanestesia/métodos
Feminino
Humanos
Injeções Intralesionais/efeitos adversos
Injeções Intralesionais/métodos
Queloide/quimioterapia
Masculino
Meia-Idade
Dor/etiologia
Medição da Dor
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Glucocorticoids); F446C597KA (Triamcinolone Acetonide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008353


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[PMID]:28774593
[Au] Autor:Liang X; Chai B; Duan R; Zhou Y; Huang X; Li Q
[Ad] Endereço:Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, People's Republic of China.
[Ti] Título:Inhibition of FKBP10 Attenuates Hypertrophic Scarring through Suppressing Fibroblast Activity and Extracellular Matrix Deposition.
[So] Source:J Invest Dermatol;137(11):2326-2335, 2017 Nov.
[Is] ISSN:1523-1747
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypertrophic scar is a pathogenic form of scar formation with no recognized treatment to date. Its molecular mechanism is related to the abnormal proliferation and transition of fibroblasts and overproduction of extracellular matrix. FKBP10 is a molecular chaperone able to regulate α-smooth muscle actin expression and pro-collagen maturation in fibroblasts. However, to our knowledge, no research has investigated the biological function of FKBP10 in scar formation to date. In this study, we aim to assess the expression and function of FKBP10 in hypertrophic scarring. Through microarray analysis, real-time reverse transcriptase-PCR and immunohistochemistry, we discovered that FKBP10 is up-regulated in human and mouse hypertrophic scars. Then we evaluated hypertrophic scar formation in mouse models treated with FKBP10 small interfering RNA and found that knockdown of FKBP10 could attenuate hypertrophic scar formation in vivo. To further explore the underlying mechanism, FKBP10 was knocked down in human hypertrophic scar fibroblasts. The in vitro results showed that FKBP10 siRNA could inhibit fibroblast activity, reduce the expression of α-smooth muscle actin and extracellular matrix components, and attenuate transforming growth factor-ß1 expression and the activation of the Smad signaling pathway. In conclusion, FKBP10 plays a crucial role in hypertrophic scar formation and might be a therapeutic target for hypertrophic scars.
[Mh] Termos MeSH primário: Cicatriz Hipertrófica/genética
Cicatriz Hipertrófica/patologia
Matriz Extracelular/metabolismo
Fibroblastos/metabolismo
Regulação da Expressão Gênica
Proteínas de Ligação a Tacrolimo/genética
[Mh] Termos MeSH secundário: Animais
Biópsia por Agulha
Bleomicina/farmacologia
Células Cultivadas
Modelos Animais de Doenças
Fibroblastos/patologia
Humanos
Imuno-Histoquímica
Camundongos
RNA Interferente Pequeno/análise
Distribuição Aleatória
Reação em Cadeia da Polimerase em Tempo Real
Sensibilidade e Especificidade
Transdução de Sinal
Regulação para Cima
Cicatrização/efeitos de drogas
Cicatrização/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Small Interfering); 11056-06-7 (Bleomycin); EC 5.2.1.- (Tacrolimus Binding Proteins); EC 5.2.1.8 (FKBP10 protein, human); EC 5.2.1.8 (Fkbp10 protein, mouse)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE


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[PMID]:28067426
[Au] Autor:Chen L; Li J; Li Q; Yan H; Zhou B; Gao Y; Li J
[Ad] Endereço:Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China.
[Ti] Título:Non-Coding RNAs: The New Insight on Hypertrophic Scar.
[So] Source:J Cell Biochem;118(8):1965-1968, 2017 Aug.
[Is] ISSN:1097-4644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypertrophic scarring (HS), a fibroproliferative disorder caused by abnormal wound healing after skin injury, is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. Numerous studies have reported that non-coding RNAs (ncRNAs) including microRNAs (miRNAs, miRs) and long non-coding RNAs (lncRNAs) play important roles in HS formation. Exploring non-coding RNA-based methods to treat scar would be instrumental for devising new effective therapies against scar. J. Cell. Biochem. 118: 1965-1968, 2017. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Cicatriz Hipertrófica/terapia
Matriz Extracelular/metabolismo
Fibroblastos/metabolismo
MicroRNAs/metabolismo
RNA Longo não Codificante/uso terapêutico
[Mh] Termos MeSH secundário: Actinas/genética
Actinas/metabolismo
Proliferação de Células
Cicatriz Hipertrófica/genética
Cicatriz Hipertrófica/metabolismo
Cicatriz Hipertrófica/patologia
Colágeno/genética
Colágeno/metabolismo
Matriz Extracelular/genética
Matriz Extracelular/patologia
Fibroblastos/patologia
Regulação da Expressão Gênica
Humanos
MicroRNAs/genética
RNA Longo não Codificante/genética
RNA Longo não Codificante/metabolismo
Transdução de Sinal
Fator de Crescimento Transformador beta/genética
Fator de Crescimento Transformador beta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (ACTA2 protein, human); 0 (Actins); 0 (MicroRNAs); 0 (RNA, Long Noncoding); 0 (Transforming Growth Factor beta); 9007-34-5 (Collagen)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE
[do] DOI:10.1002/jcb.25873


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[PMID]:28314473
[Au] Autor:Mewa Kinoo S; Singh B
[Ad] Endereço:King Edward VIII Hospital and Department of Surgery, University of KwaZulu-Natal, Durban, South Africa. Electronic address: smewakinoo@gmail.com.
[Ti] Título:Complex regional pain syndrome in burn pathological scarring: A case report and review of the literature.
[So] Source:Burns;43(3):e47-e52, 2017 May.
[Is] ISSN:1879-1409
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chronic pain in burn pathological scarring is not an uncommon occurrence. The mechanisms of pain are not clearly understood and hence the management approach is often a daunting task. However, meticulous physical examination of these patients may classify them as complex regional pain syndrome, type I. We present a patient with classic signs and symptoms of complex regional pain syndrome associated with burn pathological scarring of her left forearm that had a favourable response to a thoracoscopic sympathectomy. The possible pathological mechanisms of burn pathological scarring, mechanisms of pain, and complex regional pain syndrome are reviewed.
[Mh] Termos MeSH primário: Traumatismos do Braço/complicações
Queimaduras/complicações
Cicatriz Hipertrófica/etiologia
Síndromes da Dor Regional Complexa/cirurgia
Simpatectomia/métodos
Toracoscopia/métodos
[Mh] Termos MeSH secundário: Síndromes da Dor Regional Complexa/etiologia
Feminino
Antebraço
Humanos
Hiperpigmentação/etiologia
Hipopigmentação/etiologia
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE


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[PMID]:28109548
[Au] Autor:Agabalyan NA; Su S; Sinha S; Gabriel V
[Ad] Endereço:Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, AB T2N 4N1, Canada. Electronic address: natacha.agabalyan@gmail.com.
[Ti] Título:Comparison between high-frequency ultrasonography and histological assessment reveals weak correlation for measurements of scar tissue thickness.
[So] Source:Burns;43(3):531-538, 2017 May.
[Is] ISSN:1879-1409
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Current methods for evaluating scar tissue volume following burns have shortcomings. The Vancouver Burn Scar scale is subjective, leading to a high variability in assessment. Although histological assessment via punch biopsy can discriminate between the different layers of skin, such an approach is invasive, inefficient, and detrimental to patient experience and wound healing. This study investigates the accuracy of high-frequency ultrasonography, a non-invasive alternative to histology, for measuring dermal and epidermal thickness in scar tissue. METHODS: Scar thicknesses of 10 patients following burns were assessed using a 2-D high-frequency ultrasound probe. The scars were then biopsied using a circular 4mm punch biopsy for histological assessment. Dermal, epidermal, and total thickness of the scar tissue was measured using ultrasound and histology, and correlations between the two measurements were calculated. RESULTS: There was not a strong correlation between ultrasound measurement and histological analysis for epidermal, dermal, and total thickness (Spearman's rank correlation of -0.1223, -0.6242, and -0.6242) of scar tissue. CONCLUSIONS: Measurements of scar thickness using high-frequency ultrasonography did not recapitulate the in vivo dermal, epidermal and total thickness. Based on these findings, strategies for further optimization of 2-D ultrasonography is discussed before clinical and research use.
[Mh] Termos MeSH primário: Queimaduras/cirurgia
Cicatriz Hipertrófica/diagnóstico por imagem
Cicatriz/diagnóstico por imagem
Transplante de Pele
Pele/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Queimaduras/complicações
Cicatriz/etiologia
Cicatriz/patologia
Cicatriz Hipertrófica/patologia
Feminino
Humanos
Masculino
Meia-Idade
Tamanho do Órgão
Pele/patologia
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170122
[St] Status:MEDLINE


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[PMID]:28040366
[Au] Autor:Wei Y; Li-Tsang CW; Liu J; Xie L; Yue S
[Ad] Endereço:Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
[Ti] Título:3D-printed transparent facemasks in the treatment of facial hypertrophic scars of young children with burns.
[So] Source:Burns;43(3):e19-e26, 2017 May.
[Is] ISSN:1879-1409
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Facial burns could create serious scar problems resulting disfigurement particularly on children. The conventional methods of producing transparent face masks for scar control remains complex and require dexterous skills of experienced clinician and patients' compliance during fitting. In this study, we adopted a portable 3D scanning and Computer-Aided Design (CAD) to produce 3D-printed transparent facemasks. Its efficacy was tested on two children with facial burns resulting hypertrophic scars. METHOD: This study adopted a longitudinal case follow up research design. Two children with facial burns were recruited in the study upon consent. Their facial features were scanned with a portable 3D scanner and then edited and converted to the target files: the customized printable facemask files. The transparent facemask was directly printed out on the transparent biocompatible material followed by adding the medical grade silicone gel to provide extra pressure on the scar site. The facemasks were fitted to the patients with elastic straps connecting the printed anchoring bolts. Both children and family were instructed to wear the facemask for at least 20h per day and they were assessed before treatment, one month and three months after treatment on the facial scar conditions. RESULTS: At the one-month and three-month assessments after treatment, a decrease in average scar thickness was shown and the facial appearance was satisfactory. The 3D-printed facemasks were well fitted on both patients. The treatment was well-tolerated and no complication was reported. CONCLUSION: 3D-printed transparent facemask is convenient and efficient to fabricate, and is suitable for treating pediatric facial hypertrophic scars after burn.
[Mh] Termos MeSH primário: Queimaduras/terapia
Cicatriz Hipertrófica/terapia
Traumatismos Faciais/terapia
Máscaras
Impressão Tridimensional
Géis de Silicone/uso terapêutico
[Mh] Termos MeSH secundário: Queimaduras/complicações
Criança
Cicatriz Hipertrófica/etiologia
Projeto Auxiliado por Computador
Traumatismos Faciais/complicações
Humanos
Lactente
Estudos Longitudinais
Masculino
Transplante de Pele
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Silicone Gels)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170101
[St] Status:MEDLINE


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[PMID]:28341261
[Au] Autor:Hsiao SF; Ma H; Wang YH; Wang TH
[Ad] Endereço:Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
[Ti] Título:Occlusive drainage system for split-thickness skin graft: A prospective randomized controlled trial.
[So] Source:Burns;43(2):379-387, 2017 Mar.
[Is] ISSN:1879-1409
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Split-thickness skin grafts are widely used in reconstruction of large area defects. Conventional postoperative recipient site care includes saline-moistened gauze with a protective layer of petroleum gauze and splints for immobilization. This method causes pain while changing the dressing. We designed a better occlusive drainage system for split-thickness skin grafts. We compared the treatment effect and subjective evaluation of our occlusive drainage system with that of the conventional method for coverage of split-thickness skin grafts. METHODS: A randomized controlled trial was carried out in patients who received split-thickness skin grafts. Patients aged 24-76 years were randomly assigned to the occlusive drainage system or the conventional indirect wet dressing method. The status of graft take, pain, and subjective evaluations were compared. RESULTS: Twenty-eight participants were enrolled, with 14 in each group. The percentage of graft take was no difference between the 2 groups. No wound infection developed. Patients in the occlusive drainage system group experienced less pain and greater satisfaction. All patients followed up for at least 3 months, and no hypertrophic scar formation was noted. CONCLUSION: Comparing with the indirect wet dressing method, this new method is practical for covering split-thickness skin grafts, causes less pain, and provides a better experience for patients.
[Mh] Termos MeSH primário: Queimaduras/terapia
Drenagem/métodos
Curativos Oclusivos
Transplante de Pele
Cicatrização
[Mh] Termos MeSH secundário: Adulto
Idoso
Queimaduras/cirurgia
Cicatriz Hipertrófica/cirurgia
Feminino
Humanos
Masculino
Meia-Idade
Dor/prevenção & controle
Satisfação do Paciente
Cuidados Pós-Operatórios/métodos
Estudos Prospectivos
Transplante de Pele/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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[PMID]:28954094
[Au] Autor:Han T; Lin DF; Jiang H
[Ad] Endereço:Department of Plastic Surgery, Changzheng Hospital, The Second Military Medical University - Shanghai, China.
[Ti] Título:Wound natural healing in treatment of tumor-like hypertrophic scar.
[So] Source:An Bras Dermatol;92(4):474-477, 2017 Jul-Aug.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Background:: Surgical sutures, wound tension, additional skin incisions and other factors may result in recurrence of tumor-like scar. Objective:: To investigate the role of wound natural healing therapy in tumor-like hypertrophic scar. Methods:: In this study, tumor-like hypertrophic scars of 47 cases were excised completely and the residual wounds were treated with natural healing. The short-term and long-term effects of treatment were evaluated. Results:: All cases were successfully cured by natural healing therapy. The healing time of the maximum wound (80mm × 20mm) and the minimal wound (5mm× 5mm) was 25 days and 7 days respectively. The size of new skin scars ranged from 3mm to 11 mm. Clinical followed-up was performed in 34 cases for 36 months. Among them, no recurrence happened in 31 cases and new scar size ranged from 2mm to 8mm, while local recurrence happened in 3 cases whose scar size were less than 5 mm. Study Limitations:: The cure rate of the therapy was 91.2%. Conclusion:: The wound natural healing therapy is effective in treating tumor-like hypertrophic scar, which can prevent recurrence and has good cosmetic results.
[Mh] Termos MeSH primário: Cicatriz Hipertrófica/cirurgia
Técnicas de Fechamento de Ferimentos
Cicatrização/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Cicatriz Hipertrófica/patologia
Cicatriz Hipertrófica/prevenção & controle
Feminino
Humanos
Masculino
Meia-Idade
Período Pós-Operatório
Período Pré-Operatório
Recidiva
Infecção da Ferida Operatória/etiologia
Técnicas de Sutura/efeitos adversos
Suturas/efeitos adversos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE


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[PMID]:28423561
[Au] Autor:Zuo Y; Lu S
[Ad] Endereço:Shanghai Burns Institute, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
[Ti] Título:Dermis, acellular dermal matrix, and fibroblasts from different layers of pig skin exhibit different profibrotic characteristics: evidence from in vivo study.
[So] Source:Oncotarget;8(14):23613-23627, 2017 Apr 04.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To explore the profibrotic characteristics of the autografted dermis, acellular dermal matrix, and dermal fibroblasts from superficial/deep layers of pig skin, 93 wounds were established on the dorsa of 7 pigs. 72 wounds autografted with the superficial/deep dermis and acellular dermal matrix served as the superficial/deep dermis and acellular dermal matrix group, respectively, and were sampled at 2, 4, and 8 weeks post-wounding. 21 wounds autografted with/without superficial/deep dermal fibroblasts served as the superficial/deep dermal fibroblast group and the control group, respectively, and were sampled at 2 weeks post-wounding. The hematoxylin and eosin staining showed that the wounded skin thicknesses in the deep dermis group (superficial acellular dermal matrix group) were significantly greater than those in the superficial dermis group (deep acellular dermal matrix group) at each time point, the thickness of the cutting plane in the deep dermal fibroblast group was significantly greater than that in the superficial dermal fibroblast group and the control group. The western blots showed that the α-smooth muscle actin expression in the deep dermis group (superficial acellular dermal matrix group) was significantly greater than that in the superficial dermis group (deep acellular dermal matrix group) at each time point. In summary, the deep dermis and dermal fibroblasts exhibited more profibrotic characteristics than the superficial ones, on the contrary, the deep acellular dermal matrix exhibited less profibrotic characteristics than the superficial one.
[Mh] Termos MeSH primário: Derme Acelular/metabolismo
Derme/metabolismo
Fibroblastos/metabolismo
Transplante de Pele/métodos
Pele/metabolismo
[Mh] Termos MeSH secundário: Actinas/metabolismo
Animais
Western Blotting
Células Cultivadas
Cicatriz Hipertrófica/prevenção & controle
Derme/citologia
Modelos Animais de Doenças
Feminino
Fibroblastos/citologia
Fibrose/prevenção & controle
Humanos
Músculo Liso/química
Pele/citologia
Suínos
Fatores de Tempo
Transplante Autólogo
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.15389


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[PMID]:28472181
[Au] Autor:Wang XQ; Song F; Liu YK
[Ad] Endereço:Burn Centre, Ruijin Hospital, Jiaotong University Medical School, Shanghai, P.R. China.
[Ti] Título:Hypertrophic scar regression is linked to the occurrence of endothelial dysfunction.
[So] Source:PLoS One;12(5):e0176681, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most microvessels have been shown to become stenosed or completely occluded during hypertrophic scar progression. Here, we examined the morphology of capillary endothelial cells (ECs) and fibroblasts using immunofluorescence staining for CD31 and alpha-smooth muscle actin (α-SMA) and electron microscopy. In addition, ECs and fibroblasts were isolated from scar tissues, and the levels of transforming growth factor beta 1 (TGF-ß1), platelet-derived growth factor (PDGF), endothelin 1 (ET-1), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were assayed using ELISAs. Furthermore, we assessed cell viability, total collagen production, and cell apoptosis in hypertrophic scar-derived fibroblasts cultured with EC-conditioned medium. Then, anti-TGF-ß1, anti-PDGF, anti-ET-1, anti-VEGF, and anti-bFGF neutralising antibodies were individually added to the EC medium to identify which growth factor plays a more important role in inhibiting fibroblasts biology. Our results showed microvessel lumen occlusion and EC atrophy during scar development, particularly in regressive scars (RSs). Additionally, EC growth factor secretion decreased and reached the lowest levels in RSs. Furthermore, based on the culture results, RS EC medium inhibited fibroblast viability and collagen production and induced apoptosis. Moreover, TGF-ß1, PDGF, and bFGF played more important roles in these processes than VEGF and ET-1. The endothelial dysfunction occurring in hypertrophic scars contributes to fibroblast inhibition and scar regression, and reduced TGF-ß1, PDGF, and bFGF levels play key roles during this process.
[Mh] Termos MeSH primário: Cicatriz Hipertrófica/patologia
Endotélio/patologia
[Mh] Termos MeSH secundário: Anticorpos Neutralizantes/imunologia
Meios de Cultivo Condicionados
Progressão da Doença
Endotelina-1/imunologia
Endotelina-1/metabolismo
Ensaio de Imunoadsorção Enzimática
Humanos
Fator de Crescimento Derivado de Plaquetas/imunologia
Fator de Crescimento Derivado de Plaquetas/metabolismo
Fator de Crescimento Transformador beta1/imunologia
Fator de Crescimento Transformador beta1/metabolismo
Fator A de Crescimento do Endotélio Vascular/imunologia
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Culture Media, Conditioned); 0 (Endothelin-1); 0 (Platelet-Derived Growth Factor); 0 (Transforming Growth Factor beta1); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176681



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