Base de dados : MEDLINE
Pesquisa : Cicatriz and Hipertrófica [Palavras]
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  1 / 1803 MEDLINE  
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[PMID]:29374928
[Au] Autor:Song CL; Yao M
[Ad] Endereço:Department of Plastic Surgery and Burns, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China.
[Ti] Título:[Advances in the research of relationship between CD26 and hypertrophic scar and keloid].
[So] Source:Zhonghua Shao Shang Za Zhi;34(1):54-56, 2018 Jan 20.
[Is] ISSN:1009-2587
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:In recent years, researchers have found that CD26 (dipeptidyl peptidase 4) is closely related to the formation and development of many fibrotic diseases. Hypertrophic scar, keloid, and other skin fibrosis diseases are major problems nowadays, which may affect the patient's appearance and cause joints deformity and dysfunction due to scar contracture. This article briefly reviews the relationship between CD26 and hypertrophic scar and keloid to provide new insights into the treatment of skin fibrotic diseases.
[Mh] Termos MeSH primário: Cicatriz Hipertrófica/patologia
Dipeptidil Peptidase 4/metabolismo
Queloide/patologia
[Mh] Termos MeSH secundário: Fibrose
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
EC 3.4.14.5 (DPP4 protein, human); EC 3.4.14.5 (Dipeptidyl Peptidase 4)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1009-2587.2018.01.011


  2 / 1803 MEDLINE  
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[PMID]:29452655
[Au] Autor:Amici JM; Chaussade V
[Ad] Endereço:Service de dermatologie, hôpital Saint-André, Bordeaux, France. Electronic address: jmamici@gmail.com.
[Ti] Título:[How to optimize scarring in dermatologic surgery?]
[Ti] Título:Optimisation de la cicatrisation en chirurgie dermatologique et gestions des aléas..
[So] Source:Ann Dermatol Venereol;143 Suppl 2:S20-S25, 2016 Dec.
[Is] ISSN:0151-9638
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Scarring is the response elicited by the skin surface to injury and loss of tissue material. Wound healing takes place through a complex natural repair system consisting of vascular, inflammatory and proliferative phenomena, followed by a remodelling and cell apoptosis phase. This incredible repair system is inevitable, but sometimes unpredictable due to individual differences based on multiple factors. The scar is the objective criterion of a skin surgery, both for the patient and the dermsurgeon. It is therefore crucial to establish with the patient during the preoperative consultation, the size and positioning of the expected scar, taking into account the oncologic, anatomic and surgical constraints. Scars can ideally blend into normal skin, but may also give rise to various abnormalities. We can manage and prevent these abnormalities by mastering initial inflammation, that may induce hyperpigmentation and hypertrophy. Early massage using cortocosteroid topic or anti-inflammatory moisturizers may be effective. Random individual scarring may be minimized by a dynamic personalized accompanying scarring.
[Mh] Termos MeSH primário: Cicatriz/fisiopatologia
Procedimentos Cirúrgicos Dermatológicos/efeitos adversos
[Mh] Termos MeSH secundário: Corticosteroides/administração & dosagem
Anti-Inflamatórios/administração & dosagem
Cicatriz/prevenção & controle
Cicatriz Hipertrófica/fisiopatologia
Cicatriz Hipertrófica/prevenção & controle
Terapia Combinada
Eritema/fisiopatologia
Eritema/prevenção & controle
Hiperpigmentação/fisiopatologia
Hiperpigmentação/prevenção & controle
Queloide/fisiopatologia
Massagem
Educação de Pacientes como Assunto
Fatores de Risco
Pele/fisiopatologia
Transplante de Pele
Protetores Solares/administração & dosagem
Telangiectasia/fisiopatologia
Telangiectasia/prevenção & controle
Cicatrização/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Anti-Inflammatory Agents); 0 (Sunscreening Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180218
[St] Status:MEDLINE


  3 / 1803 MEDLINE  
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[PMID]:29188931
[Au] Autor:Kaartinen I
[Ti] Título:Treatment of hypertrophic scars and keloids.
[So] Source:Duodecim;132(16):1439-47, 2016.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:Differentiation of a hypertrophic scar from a keloid is important with regard to the planning of treatment. Keloids arise following any skin injury and may grow disproportionately large as compared with the original wound. Treatment of keloids is challenging both for the patient and the attending physician. Treatment of hypertrophic scars aims to abate the symptoms and accelerate scar maturation. The goal in the treatment of keloids is excision of the keloid or stopping its growth, lessening of symptoms and avoidance of recurrence.
[Mh] Termos MeSH primário: Cicatriz Hipertrófica/diagnóstico
Cicatriz Hipertrófica/terapia
Queloide/diagnóstico
Queloide/terapia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Recidiva
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  4 / 1803 MEDLINE  
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[PMID]:29069016
[Au] Autor:Wang X; Wu X; Liu K; Xia L; Lin X; Liu W; Gao Z
[Ad] Endereço:aDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine bShanghai Key Laboratory of Tissue Engineering, Shanghai, China.
[Ti] Título:Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids.
[So] Source:Medicine (Baltimore);96(43):e8353, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intralesional steroid injections are the standard treatment for hypertrophic scars and keloids. The procedure is, however, quite painful and is unpopular with patients because of this. Topical application of anesthetic creams, such as Ametop gel (tetracaine) and EMLA cream (lidocaine and prilocaine), has limited efficacy because of poor drug penetration. The onset of the analgesic effect is also slow, which means that the use of topical anesthetics is time-consuming in clinical practice.We hypothesized that a commercially available cryotip could be used to provide fast-acting topical cryoanesthesia that would reduce the pain associated with steroid injections.Thirty patients with hypertrophic scars or keloids were enrolled in the study. Scars were injected with the steroid, triamcinolone acetonide, with or without prior application of the cryotip (-10 °C) for 15 seconds. The degree of pain was evaluated in each case using the visual analogue scale (VAS) and the verbal descriptor scale (VDS), together with any side-effects caused by application of the cryotip.The VAS pain scores showed a statistically significant (P < .01) difference between the pretreated and the control scars (pain scores 7.87 ±â€Š1.31 and 2.7 ±â€Š1.37, respectively). The VDS pain scores also showed a statistically significant (P < .01) difference between the pretreated and the control scars. And its average scores were 7.89 ±â€Š0.32 and 2.68 ±â€Š0.25, respectively.Application of the cryotip before injection could provide a rapid and effective means of reducing the pain associated with steroid injections. Painless would result in better therapeutic effect.
[Mh] Termos MeSH primário: Anestésicos Locais/administração & dosagem
Crioanestesia/instrumentação
Glucocorticoides/administração & dosagem
Dor/tratamento farmacológico
Triancinolona Acetonida/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Cicatriz Hipertrófica/tratamento farmacológico
Crioanestesia/métodos
Feminino
Seres Humanos
Injeções Intralesionais/efeitos adversos
Injeções Intralesionais/métodos
Queloide/tratamento farmacológico
Masculino
Meia-Idade
Dor/etiologia
Medição da Dor
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Glucocorticoids); F446C597KA (Triamcinolone Acetonide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008353


  5 / 1803 MEDLINE  
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[PMID]:28954094
[Au] Autor:Han T; Lin DF; Jiang H
[Ad] Endereço:Department of Plastic Surgery, Changzheng Hospital, The Second Military Medical University - Shanghai, China.
[Ti] Título:Wound natural healing in treatment of tumor-like hypertrophic scar.
[So] Source:An Bras Dermatol;92(4):474-477, 2017 Jul-Aug.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Background:: Surgical sutures, wound tension, additional skin incisions and other factors may result in recurrence of tumor-like scar. Objective:: To investigate the role of wound natural healing therapy in tumor-like hypertrophic scar. Methods:: In this study, tumor-like hypertrophic scars of 47 cases were excised completely and the residual wounds were treated with natural healing. The short-term and long-term effects of treatment were evaluated. Results:: All cases were successfully cured by natural healing therapy. The healing time of the maximum wound (80mm × 20mm) and the minimal wound (5mm× 5mm) was 25 days and 7 days respectively. The size of new skin scars ranged from 3mm to 11 mm. Clinical followed-up was performed in 34 cases for 36 months. Among them, no recurrence happened in 31 cases and new scar size ranged from 2mm to 8mm, while local recurrence happened in 3 cases whose scar size were less than 5 mm. Study Limitations:: The cure rate of the therapy was 91.2%. Conclusion:: The wound natural healing therapy is effective in treating tumor-like hypertrophic scar, which can prevent recurrence and has good cosmetic results.
[Mh] Termos MeSH primário: Cicatriz Hipertrófica/cirurgia
Técnicas de Fechamento de Ferimentos
Cicatrização/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Cicatriz Hipertrófica/patologia
Cicatriz Hipertrófica/prevenção & controle
Feminino
Seres Humanos
Masculino
Meia-Idade
Período Pós-Operatório
Período Pré-Operatório
Recidiva
Infecção da Ferida Cirúrgica/etiologia
Técnicas de Sutura/efeitos adversos
Suturas/efeitos adversos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


  6 / 1803 MEDLINE  
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[PMID]:28774593
[Au] Autor:Liang X; Chai B; Duan R; Zhou Y; Huang X; Li Q
[Ad] Endereço:Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, People's Republic of China.
[Ti] Título:Inhibition of FKBP10 Attenuates Hypertrophic Scarring through Suppressing Fibroblast Activity and Extracellular Matrix Deposition.
[So] Source:J Invest Dermatol;137(11):2326-2335, 2017 Nov.
[Is] ISSN:1523-1747
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypertrophic scar is a pathogenic form of scar formation with no recognized treatment to date. Its molecular mechanism is related to the abnormal proliferation and transition of fibroblasts and overproduction of extracellular matrix. FKBP10 is a molecular chaperone able to regulate α-smooth muscle actin expression and pro-collagen maturation in fibroblasts. However, to our knowledge, no research has investigated the biological function of FKBP10 in scar formation to date. In this study, we aim to assess the expression and function of FKBP10 in hypertrophic scarring. Through microarray analysis, real-time reverse transcriptase-PCR and immunohistochemistry, we discovered that FKBP10 is up-regulated in human and mouse hypertrophic scars. Then we evaluated hypertrophic scar formation in mouse models treated with FKBP10 small interfering RNA and found that knockdown of FKBP10 could attenuate hypertrophic scar formation in vivo. To further explore the underlying mechanism, FKBP10 was knocked down in human hypertrophic scar fibroblasts. The in vitro results showed that FKBP10 siRNA could inhibit fibroblast activity, reduce the expression of α-smooth muscle actin and extracellular matrix components, and attenuate transforming growth factor-ß1 expression and the activation of the Smad signaling pathway. In conclusion, FKBP10 plays a crucial role in hypertrophic scar formation and might be a therapeutic target for hypertrophic scars.
[Mh] Termos MeSH primário: Cicatriz Hipertrófica/genética
Cicatriz Hipertrófica/patologia
Matriz Extracelular/metabolismo
Fibroblastos/metabolismo
Regulação da Expressão Gênica
Proteínas de Ligação a Tacrolimo/genética
[Mh] Termos MeSH secundário: Animais
Biópsia por Agulha
Bleomicina/farmacologia
Células Cultivadas
Modelos Animais de Doenças
Fibroblastos/patologia
Seres Humanos
Imuno-Histoquímica
Camundongos
RNA Interferente Pequeno/análise
Distribuição Aleatória
Reação em Cadeia da Polimerase em Tempo Real
Sensibilidade e Especificidade
Transdução de Sinais
Regulação para Cima
Cicatrização/efeitos dos fármacos
Cicatrização/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Small Interfering); 11056-06-7 (Bleomycin); EC 5.2.1.- (Tacrolimus Binding Proteins); EC 5.2.1.8 (FKBP10 protein, human); EC 5.2.1.8 (Fkbp10 protein, mouse)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


  7 / 1803 MEDLINE  
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[PMID]:28763906
[Au] Autor:Cai JH; Deng HP; Shen ZA; Sun TJ; Li DJ; Li DW; He LX; Wang L; Jin X
[Ad] Endereço:Burns Institute, the First Hospital Affiliated to the PLA General Hospital, Beijing 100048, China.
[Ti] Título:[Effects of scar excision combined with negative-pressure on repair of hypertrophic scar in burn children].
[So] Source:Zhonghua Shao Shang Za Zhi;33(7):410-414, 2017 Jul 20.
[Is] ISSN:1009-2587
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To explore the effects of scar excision combined with negative-pressure on repair of hypertrophic scar in burn children. From October 2010 to August 2016, 25 children with hypertrophic scar after deep burn were hospitalized, with scar course ranging from 3 months to 11 years and scar area ranging from 35 to 427 [83(51, 98)]cm(2). A total of 35 scars of 25 children were located in trunk (11 scars), upper limb (11 scars), and lower limb (13 scars). All children received scar excision operation and negative-pressure treatment (negative-pressure value ranged from -40 to -20 kPa), among which 6 cases received scar excision operation and negative-pressure treatment for two times for further removal of scars. After scar excision, electronic spring scale was used to measure the tension of the incision. The tension value of children ranged from 3.43 to 23.84 [7.16 (5.59, 9.12)] N, and then the incision was closed with appropriate suture according to the value of the tension. The incision with smaller tension was firstly opened on post operation day (POD) 8. After removing the suture, negative-pressure was conducted to POD 14. The incision with larger tension was firstly opened on POD 12. After removing the suture, biological semi-membrane was used to reduce tension to POD 16. All healed incisions were performed with anti-scar treatment for 1 year and relaxation and fixation for 3 months. General condition of the incision was observed after operation. The reduction percentage of scar area was calculated half-year after operation. The Patient and Observer Scar Assessment Scale was used to record the overall score of scar and scar score of trunk, upper limb, and lower limb before operation and half-year after operation. Data were processed with paired test and Wilcoxon rank sum test. After removing the suture, all incisions of children healed well without redness, effusion, and rupture. Half-year after operation, the appearance and deformity of incision were obviously improved, and the symptoms including pruritus and pain were basically relieved. Half-year after operation, the scar area of children ranged from 0 to 174 [21(9, 47)]cm(2,) which was significantly decreased as compared with that before operation ( =-5.16, <0.05). The reduction percentage of scar area ranged from 36% to 100% [(73±19)%]. Half-year after operation, the overall score of scar and scar score of trunk, upper limb, and lower limb of children were obviously decreased as compared with those before operation (with values from 6.42 to 17.37, values below 0.05). Scar excision combined with negative-pressure treatment has a good clinical effect on repair of hypertrophic scar in burn children, which is suitable for clinical application.
[Mh] Termos MeSH primário: Queimaduras/complicações
Cicatriz Hipertrófica/terapia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Cicatriz Hipertrófica/etiologia
Bandagens Compressivas
Feminino
Seres Humanos
Lactente
Masculino
Pressão
Prurido
Suturas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1009-2587.2017.07.003


  8 / 1803 MEDLINE  
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[PMID]:28654594
[Au] Autor:Chen HC; Yen CI; Yang SY; Chang CJ; Yang JY; Chang SY; Chuang SS; Hsiao YC
[Ad] Endereço:Taoyuan, Taiwan From the Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University.
[Ti] Título:Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model.
[So] Source:Plast Reconstr Surg;140(1):43e-49e, 2017 Jul.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The authors evaluated the efficacy of a combined regimen of botulinum toxin type A (Botox) and a steroid (triamcinolone acetonide) for treating hypertrophic scars in comparison with the treatment with each drug alone. METHODS: Twenty excised human hypertrophic scar fragments obtained from surgically treated burn patients were divided into four groups: negative control (group A), triamcinolone alone (group B), Botox alone (group C), and a combination of triamcinolone and Botox (group D). These specimens were implanted into the backs of nude mice after intralesional injection from each group and were observed for 4 weeks. In total, 12 mice and 48 scars were studied. After 4 weeks, the hypertrophic scars were removed from the backs. The authors compared the scar weights, decorin staining, and the Cell Counting Kit-8 assay to evaluate treatment efficacy. RESULTS: Significant differences in scar weight reduction were observed among the four groups (group A, 10 percent; group B, 17 percent; group C, 23 percent; and group D, 30 percent; p < 0.05). Treatment groups (groups B, C, and D) showed strong decorin staining. Significant differences in reduction of fibroblast proliferation were observed among the four groups (group A, 0.58; group B, 0.44; group C, 0.21; and group D, 0.08; p < 0.05). Botox or triamcinolone intralesional monotherapy showed significant therapeutic efficacy compared with the control group. The combined therapy further exhibited a significant therapeutic effect compared with monotherapy. CONCLUSION: This study indicates the potential of Botox and triamcinolone when combined for intralesional therapy in treating hypertrophic scars.
[Mh] Termos MeSH primário: Toxinas Botulínicas Tipo A/administração & dosagem
Cicatriz Hipertrófica/tratamento farmacológico
Glucocorticoides/administração & dosagem
Triancinolona Acetonida/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Quimioterapia Combinada
Seres Humanos
Camundongos
Camundongos Nus
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); E211KPY694 (onabotulinumtoxinA); EC 3.4.24.69 (Botulinum Toxins, Type A); F446C597KA (Triamcinolone Acetonide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003426


  9 / 1803 MEDLINE  
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[PMID]:28472181
[Au] Autor:Wang XQ; Song F; Liu YK
[Ad] Endereço:Burn Centre, Ruijin Hospital, Jiaotong University Medical School, Shanghai, P.R. China.
[Ti] Título:Hypertrophic scar regression is linked to the occurrence of endothelial dysfunction.
[So] Source:PLoS One;12(5):e0176681, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most microvessels have been shown to become stenosed or completely occluded during hypertrophic scar progression. Here, we examined the morphology of capillary endothelial cells (ECs) and fibroblasts using immunofluorescence staining for CD31 and alpha-smooth muscle actin (α-SMA) and electron microscopy. In addition, ECs and fibroblasts were isolated from scar tissues, and the levels of transforming growth factor beta 1 (TGF-ß1), platelet-derived growth factor (PDGF), endothelin 1 (ET-1), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were assayed using ELISAs. Furthermore, we assessed cell viability, total collagen production, and cell apoptosis in hypertrophic scar-derived fibroblasts cultured with EC-conditioned medium. Then, anti-TGF-ß1, anti-PDGF, anti-ET-1, anti-VEGF, and anti-bFGF neutralising antibodies were individually added to the EC medium to identify which growth factor plays a more important role in inhibiting fibroblasts biology. Our results showed microvessel lumen occlusion and EC atrophy during scar development, particularly in regressive scars (RSs). Additionally, EC growth factor secretion decreased and reached the lowest levels in RSs. Furthermore, based on the culture results, RS EC medium inhibited fibroblast viability and collagen production and induced apoptosis. Moreover, TGF-ß1, PDGF, and bFGF played more important roles in these processes than VEGF and ET-1. The endothelial dysfunction occurring in hypertrophic scars contributes to fibroblast inhibition and scar regression, and reduced TGF-ß1, PDGF, and bFGF levels play key roles during this process.
[Mh] Termos MeSH primário: Cicatriz Hipertrófica/patologia
Endotélio/patologia
[Mh] Termos MeSH secundário: Anticorpos Neutralizantes/imunologia
Meios de Cultivo Condicionados
Progressão da Doença
Endotelina-1/imunologia
Endotelina-1/metabolismo
Ensaio de Imunoadsorção Enzimática
Seres Humanos
Fator de Crescimento Derivado de Plaquetas/imunologia
Fator de Crescimento Derivado de Plaquetas/metabolismo
Fator de Crescimento Transformador beta1/imunologia
Fator de Crescimento Transformador beta1/metabolismo
Fator A de Crescimento do Endotélio Vascular/imunologia
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Culture Media, Conditioned); 0 (Endothelin-1); 0 (Platelet-Derived Growth Factor); 0 (Transforming Growth Factor beta1); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176681


  10 / 1803 MEDLINE  
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[PMID]:28423561
[Au] Autor:Zuo Y; Lu S
[Ad] Endereço:Shanghai Burns Institute, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
[Ti] Título:Dermis, acellular dermal matrix, and fibroblasts from different layers of pig skin exhibit different profibrotic characteristics: evidence from in vivo study.
[So] Source:Oncotarget;8(14):23613-23627, 2017 Apr 04.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To explore the profibrotic characteristics of the autografted dermis, acellular dermal matrix, and dermal fibroblasts from superficial/deep layers of pig skin, 93 wounds were established on the dorsa of 7 pigs. 72 wounds autografted with the superficial/deep dermis and acellular dermal matrix served as the superficial/deep dermis and acellular dermal matrix group, respectively, and were sampled at 2, 4, and 8 weeks post-wounding. 21 wounds autografted with/without superficial/deep dermal fibroblasts served as the superficial/deep dermal fibroblast group and the control group, respectively, and were sampled at 2 weeks post-wounding. The hematoxylin and eosin staining showed that the wounded skin thicknesses in the deep dermis group (superficial acellular dermal matrix group) were significantly greater than those in the superficial dermis group (deep acellular dermal matrix group) at each time point, the thickness of the cutting plane in the deep dermal fibroblast group was significantly greater than that in the superficial dermal fibroblast group and the control group. The western blots showed that the α-smooth muscle actin expression in the deep dermis group (superficial acellular dermal matrix group) was significantly greater than that in the superficial dermis group (deep acellular dermal matrix group) at each time point. In summary, the deep dermis and dermal fibroblasts exhibited more profibrotic characteristics than the superficial ones, on the contrary, the deep acellular dermal matrix exhibited less profibrotic characteristics than the superficial one.
[Mh] Termos MeSH primário: Derme Acelular/metabolismo
Derme/metabolismo
Fibroblastos/metabolismo
Transplante de Pele/métodos
Pele/metabolismo
[Mh] Termos MeSH secundário: Actinas/metabolismo
Animais
Western Blotting
Células Cultivadas
Cicatriz Hipertrófica/prevenção & controle
Derme/citologia
Modelos Animais de Doenças
Feminino
Fibroblastos/citologia
Fibrose/prevenção & controle
Seres Humanos
Músculo Liso/química
Pele/citologia
Suínos
Fatores de Tempo
Transplante Autólogo
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.15389



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