Base de dados : MEDLINE
Pesquisa : Commiphora [Palavras]
Referências encontradas : 431 [refinar]
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  1 / 431 MEDLINE  
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[PMID]:29430927
[Au] Autor:Liu JW; Zhang MY; Yan YM; Wei XY; Dong L; Zhu YX; Cheng YX
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, PR China.
[Ti] Título:Characterization of Sesquiterpene Dimers from Resina Commiphora That Promote Adipose-Derived Stem Cell Proliferation and Differentiation.
[So] Source:J Org Chem;83(5):2725-2733, 2018 Mar 02.
[Is] ISSN:1520-6904
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The new sesquiterpene dimers commiphoroids A-D (1-4) were isolated from Resina Commiphora, and their structures were assigned by spectroscopic methods and X-ray diffraction analysis. Compounds 1 and 2 are stereoisomers of putative [2 + 4]-cycloaddition reactions, and 3 is a trinorsesquiterpene dimer containing a 6/6/5/6/6/6 hexacyclic framework, while 4 possesses a 8-oxabicyclo[3.2.1]oct-6-ene skeletal core. Plausible biosynthetic pathways for 1-4 are proposed. Biochemical studies show that compound 1 promotes ca. 60% expression of keratinocyte-specific markers in adipose-derived stem cells at 10 µM.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[St] Status:In-Data-Review
[do] DOI:10.1021/acs.joc.7b03182


  2 / 431 MEDLINE  
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[PMID]:29393680
[Au] Autor:Bhatia A; Tripathi T; Singh S; Bisht H; Behl HM; Roy R; Sidhu OP
[Ad] Endereço:a CSIR-National Botanical Research Institute , Lucknow , India.
[Ti] Título:Comprehensive metabolite profiling in distinct chemotypes of Commiphora wightii.
[So] Source:Nat Prod Res;:1-7, 2018 Feb 02.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Commiphora wightii (Arn.) Bhandari, known as guggul, produces a medicinally important gum resin which is used extensively by Ayurvedic physicians to treat various ailments. However, most of the studies on C. wightii have been limited to its gum resin. Comprehensive metabolic profiling of leaves, stem and gum resin samples was undertaken to analyse aqueous and non-aqueous metabolites from three distinct chemotypes (NBRI-101, NBRI-102 and NBRI-103) shortlisted from different agro-climatic zones. GC-MS, HPLC and NMR spectroscopy were used for comprehensive metabolomics. Multivariate analysis showed characteristic variation in quinic and citric acids, myo-inositol and glycine (aqueous metabolites) and 2,6-di-tert-butyl-phenol, trans-farnesol and guggulsterones (non-aqueous metabolites) amongst the three chemotypes. Quinic acid, citric acid and myo-ionositol were detected in substantial quantities from leaves and stem samples which provide opportunities for novel nutraceutical and pharmaceutical formulations. Quinic acid, from the leaves, was identified as a marker metabolite for early selection of high guggulsterones-yielding cultivars.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[St] Status:Publisher
[do] DOI:10.1080/14786419.2018.1431629


  3 / 431 MEDLINE  
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[PMID]:29228822
[Au] Autor:Shokoohi R; Kianbakht S; Faramarzi M; Rahmanian M; Nabati F; Mehrzadi S; Huseini HF
[Ad] Endereço:1 Shahrekord University, Shahrekord, Iran.
[Ti] Título:Effects of an Herbal Combination on Glycemic Control and Lipid Profile in Diabetic Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
[So] Source:J Evid Based Complementary Altern Med;22(4):798-804, 2017 Oct.
[Is] ISSN:2156-5899
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study was conducted to explore the efficacy and safety of a herbal combination in the treatment of women with hyperlipidemic type 2 diabetes. The herbal combination capsule (600 mg) contained Terminalia chebula fruit extract (200 mg), Commiphora mukul (200 mg), and Commiphora myrrha oleo-gum-resin (200 mg), and the placebo capsule contained 600 mg toast powder. The patients in one group took the herbal combination and those in the other group took placebo capsules 3 times a day for 3 months. In the herbal combination-treated patients, the fasting blood glucose, total cholesterol, and low-density lipoprotein cholesterol levels were decreased and hidh-density lipoprotein cholesterol levels was increased significantly at the endpoint compared with the placebo and baseline. Other blood parameters such as glycosylated hemoglobin, triglyceride, blood urea nitrogen, creatinine, SGOT, and SGPT levels were not significantly changed after 3 months in both groups. In conclusion, the herbal combination improves glycemic control and lipid profile in women with hyperlipidemic type 2 diabetes without any adverse events.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[St] Status:In-Data-Review
[do] DOI:10.1177/2156587217737683


  4 / 431 MEDLINE  
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[PMID]:29124622
[Au] Autor:Memariani Z; Moeini R; Hamedi SS; Gorji N; Mozaffarpur SA
[Ad] Endereço:Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Islamic Republic of Iran.
[Ti] Título:Medicinal plants with antithrombotic property in Persian medicine: a mechanistic review.
[So] Source:J Thromb Thrombolysis;, 2017 Nov 09.
[Is] ISSN:1573-742X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessels diseases. Due to the high prevalence of thromboembolic disorders investigations are being carried out on new antithrombotic agents with limited adverse side effects in which herbal medicines are considered as alternative remedies. Persian medicine (PM) as a traditional medicine has a good potential for pharmacotherapy based on its own principles and development of drugs via investigating PM literature. In PM manuscripts there are some concepts that express the management of blood clots and antithrombotic properties. This study reviewed the pharmacological effects of medicinal plants mentioned in PM literature for blood clot management in light of current knowledge. Plants mentioned in PM for management of blood clot belong to 12 families in which Apiaceae, Lamiaceae and Compositae were the most repeated ones. Among the proposed plants Allium sativum, Rosmarinus officinalis, Boswellia serrata, Sesamum indicum, Matricaria chamomilla and Carthamus tinctorius have been the most researched plants in modern antithrombotic studies while for some plants such as Helichrysum stoechas, Dracocephalum kotschi, Carum carvi, Bunium persicum and Lagoecia cuminoides no evidence could be found. One of the interesting notes in clot management in PM texts was introducing the target organ for some of the recommended herbs like Carum carvi and Bunium persicum for dissolving blood clot in stomach and Commiphora mukul for thrombosed hemorrhoid. It seems review of PM recommendations can help to design future researches for antithrombotic drugs discovering with more effectiveness and safety.
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[St] Status:Publisher
[do] DOI:10.1007/s11239-017-1580-3


  5 / 431 MEDLINE  
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[PMID]:28930280
[Au] Autor:Dudai N; Shachter A; Satyal P; Setzer WN
[Ad] Endereço:Agricultural Research Organization, Unit of Medicinal and Aromatic Plants, Newe Ya'ar Research Center, POB 1021, Ramat Yishay 30095, Israel. nativdud@gmail.com.
[Ti] Título:Chemical Composition and Monoterpenoid Enantiomeric Distribution of the Essential Oils from Apharsemon (Commiphora gileadensis).
[So] Source:Medicines (Basel);4(3), 2017 Sep 12.
[Is] ISSN:2305-6320
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:(Hebrew: apharsemon) has been used since Biblical times to treat various ailments, and is used today in the traditional medicine of some Middle Eastern cultures. The essential oils from the stem bark, leaves, and fruits of -collected at the Ein Gedi Botanical Garden, Israel-were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. In addition, the enantiomeric distributions of the monoterpenoids in the essential oils have been determined by chiral gas chromatography. The essential oils were dominated by monoterpene hydrocarbons, followed by oxygenated monoterpenoids. The major components in oils were the monoterpenes α-pinene (11.1-18.4%), sabinene (15.8-35.9%), ß-pinene (5.8-18.0%), -cymene (4.8-8.4%), limonene (1.3-6.2%), γ-terpinene (0.7-8.1%), and terpinen-4-ol (5.3-18.5%). The (-)-enantiomers predominated for α-pinene, sabinene, ß-pinene, limonene, and terpinen-4-ol. The chemical compositions of the essential oils from Israel are markedly different from previously reported samples, which were rich in sesquiterpenoids. Likewise, the enantiomeric distribution of monoterpenoids is very different from spp. essential oils.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[St] Status:PubMed-not-MEDLINE


  6 / 431 MEDLINE  
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[PMID]:28882548
[Au] Autor:Bamford MK
[Ad] Endereço:Evolutionary Studies Institute and School of Geosciences, University of the Witwatersrand, Private Bag 3, WITS 2050, Johannesburg, South Africa. Electronic address: Marion.bamford@wits.ac.za.
[Ti] Título:Pleistocene fossil woods from the Okote Member, site FwJj 14 in the Ileret region, Koobi Fora Formation, northern Kenya.
[So] Source:J Hum Evol;112:134-147, 2017 Nov.
[Is] ISSN:1095-8606
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:On the eastern side of Lake Turkana in northern Kenya are extensive Plio-Pleistocene deposits containing a rich diversity of fossil mammals, hominins and flora within the radiometrically dated tuffaceous, lacustrine and fluvial sequence. Reconstruction of this landscape and paleoenvironment are part of an ongoing multinational and multidisciplinary human evolution project in the eastern Turkana Basin. Today there is a huge lake in the Rift Valley but it has fluctuated since the early Pliocene. Silicified wood is fairly common in some areas of the Koobi Fora Formation. One such site is FwJj 14E, alongside one of the tributaries of the Ileret River. Hominin hand and arm bones have been excavated from here in the Okote Member and dated at 1.56-1.36 Ma. The fossils are associated with hominin and bovid footprints. Sixty of the over 100 wood specimens collected have been sectioned and studied. In general the woods have large vessels and an average vulnerability index of 40, which implies a mesic megathermal environment with no water stress. Taxonomically the woods belong to large African families: Caesalpiniaceae (Didelotia idae), Combretaceae (Anogeissus sp.), Putranjivaceae (Euphorbiaceae; Drypetes sp.), Lamiaceae (cf Premna sp.), Malvaceae (Heritiera sp.) and Sapindaceae (Sapindoxylon sp.). Most of these taxa do not occur in the area today because now it is much drier and the local vegetation is predominantly Acacia-Commiphora-Salvadora shrubland. The reconstruction of the paleovegetation supports the interpretation from the fauna, namely, a tall riverine forest with shady refuge trees, possibly some edible fruits, and wooded grassland and more open bushland in the vicinity.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[St] Status:In-Process


  7 / 431 MEDLINE  
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[PMID]:28725152
[Au] Autor:Ahamad SR; Al-Ghadeer AR; Ali R; Qamar W; Aljarboa S
[Ad] Endereço:Central Laboratory, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
[Ti] Título:Analysis of inorganic and organic constituents of myrrh resin by GC-MS and ICP-MS: An emphasis on medicinal assets.
[So] Source:Saudi Pharm J;25(5):788-794, 2017 Jul.
[Is] ISSN:1319-0164
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Ab] Resumo:The aim of the present investigation was to explore the constituents of the Arabian myrrh resin obtained from The organic and inorganic composition of the myrrh gum resin has been investigated using gas chromatography-mass spectrometry (GC-MS) and inductively coupled plasma-mass spectrometry (ICP-MS). Analysis executed by ICP-MS reveals the presence of various inorganic elements in significant amount in the myrrh resin. The elements that were found to be present in large amounts include calcium, magnesium, aluminum, phosphorus, chlorine, chromium, bromine and scandium. The important organic constituents identified in the myrrh ethanolic extract include limonene, curzerene, germacrene B, isocericenine, myrcenol, beta selinene, and spathulenol,. The present work complements other myrrh associated investigations done in the past and provides additional data for the future researches.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170723
[Lr] Data última revisão:
170723
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1016/j.jsps.2016.10.011


  8 / 431 MEDLINE  
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[PMID]:28584486
[Au] Autor:Sairkar PK; Sharma A; Shukla NP
[Ad] Endereço:Centre of Excellence in Biotechnology, M. P. Council of Science and Technology, Bhopal, Madhya Pradesh, India.
[Ti] Título:Estimation of Guggulsterone E and Z in the Guggul-based Commercial Formulations Using High-performance Thin-layer Chromatography.
[So] Source:J Pharm Bioallied Sci;9(1):1-7, 2017 Jan-Mar.
[Is] ISSN:0976-4879
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Guggulsterone (GS) is a plant steroid and bioactive compound present in gum Guggul of . An Indian herbal medicine system "Ayurveda" has a long history of use of gum Guggul and plant extract of as medicine for the treatment of various illnesses. Complex nature, low availability, and inconsistency of phytoconstituents make its analysis of difficult tasks. AIMS: In this work, six different Guggul-based herbal formulations were examined for estimation of GS and their isomers (E and Z) through high-performance thin-layer chromatography technique. MATERIALS AND METHODS: For that various concentrations of standard E-GS and Z-GS (50 ng-250 ng/spot) with samples (20 µg/spot) were applied on silica gel coated aluminum plate and developed with the mobile phase of toluene: ethyl acetate: formic acid: methanol (6:2:1:0.5). The scanning was performed at 254 nm wavelength and the absorbance (scan) spectrum of E-GS and Z-GS peak was generated at 200 nm-400 nm wavelength range. RESULTS AND CONCLUSIONS: R value and scan spectrum pattern of the samples reveal that they contain either one form of GS (E-GS, Z-GS) or both. The quantity of E-GS and Z-GS within the samples was ranged from 0.230 ± 0.0040-0.926 ± 0.0168% to 0.537 ± 0.0026-0.723 ± 0.0177%, respectively.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/0975-7406.206225


  9 / 431 MEDLINE  
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[PMID]:28582635
[Au] Autor:El-Gamal AA; Al-Massarani SM; Abdel-Mageed WM; El-Shaibany A; Al-Mahbashi HM; Basudan OA; Badria FA; Al-Said MS; Abdel-Kader MS
[Ad] Endereço:Department of Pharmacognosy, King Saud University, College of Pharmacy, P.O. Box 2457, Riyadh, 11451, Saudi Arabia; Department of Pharmacognosy, Mansoura University, Faculty of Pharmacy, 35516, El-Mansoura, Egypt. Electronic address: aelgamal00@yahoo.com.
[Ti] Título:Prenylated flavonoids from Commiphora opobalsamum stem bark.
[So] Source:Phytochemistry;141:80-85, 2017 Sep.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A-E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7). Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC values of 8 and 12 µg/mL, respectively.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Commiphora/química
Flavonoides/química
Casca de Planta/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Ensaios de Seleção de Medicamentos Antitumorais
Flavonoides/isolamento & purificação
Células Hep G2
Seres Humanos
Células MCF-7
Estrutura Molecular
Prenilação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Flavonoids)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


  10 / 431 MEDLINE  
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[PMID]:28535783
[Au] Autor:Nagagi YP; Silayo RS; Luziga C; Kweka EJ
[Ad] Endereço:Department of Microbiology, Parasitology and Immunology, College of Veterinary and Medical Sciences, Sokoine University of Agriculture, P. O. Box 3019, Chuo Kikuu, Morogoro, Tanzania. petnagagi@gmail.com.
[Ti] Título:In vivo effect of Commiphora swynnertonii ethanolic extracts on Trypanosoma congolense and selected immunological components in mice.
[So] Source:BMC Complement Altern Med;17(1):275, 2017 May 23.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The search for alternative trypanocidal compounds which can be available at affordable price is of paramount importance for control of trypanosomosis in human and animals. The current study evaluates the in vivo activity of ethanolic stem bark extracts on Trypanosoma congolense and selected immunological components in an inbred Swiss albino mouse model. METHODS: Groups of mice infected with T. congolense were treated with the stem bark extracts at a rate of 1000 mg/kg, 1500 mg/kg, and 2000 mg/kg, twice a day in one set and thrice a day in another setting for three days consecutively. Negative (infected and untreated) and positive (infected treated with diminazene diaceturate at 3.5 mg/kg) control groups were used. Levels of parasitaemia were monitored daily for the first 10 days and thereafter 2-3 times per week to the end of experiment. In the other setting, uninfected mice, randomized in groups were treated with the extract but categorized as: thorough mixed extract (TME) and supernatant extract (SE) each at 500 mg/kg and 1500 mg/kg, in 8 hourly intervals respectively for three days consecutively. Control group was administered with phosphate buffered saline with glucose at 0.1 ml/10 g in a similar manner as for the extract. Whole blood and spleen were taken 24 h after the last treatment for hematological and histopathological analysis. RESULTS: The groups that received the extracts at 8 hourly intervals drastically reduced the parasitaemia. The higher dose of SE significantly reduced the percentage of lymphocytes (P < 0.05). Both high and low dose of TME significantly reduced lymphocytes percent (P < 0.05) while percent of neutrophils and monocytes increased significantly (P < 0.05). Histopathological changes of the spleen in the mice treated with higher concentrations of the extract of C. swynnertonii were suggestive of lymphocytes toxicity. CONCLUSION: The current study has provided evidence that, in vivo trypanocidal activity of ethanolic bark extracts of C. swynnertonii is probably affected by its negative effect on humoral mediated immune response. Further studies are recommended to determine its potential as an alternative source of lead compounds for trypanocidal drug discovery.
[Mh] Termos MeSH primário: Commiphora/química
Extratos Vegetais/administração & dosagem
Tripanossomicidas/administração & dosagem
Trypanosoma congolense/efeitos dos fármacos
Tripanossomíase Africana/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Seres Humanos
Masculino
Camundongos
Fitoterapia
Casca de Planta/química
Extratos Vegetais/isolamento & purificação
Resultado do Tratamento
Tripanossomicidas/isolamento & purificação
Trypanosoma congolense/fisiologia
Tripanossomíase Africana/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Trypanocidal Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1785-1



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