Base de dados : MEDLINE
Pesquisa : Doenças and Sexualmente and Transmissíveis [Palavras]
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  1 / 20075 MEDLINE  
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[PMID]:24443101
[Au] Autor:Muessig KE; Smith MK; Maman S; Huang Y; Chen XS
[Ad] Endereço:Department of Health Behavior, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7440, USA, kmuessig@med.unc.edu.
[Ti] Título:Advancing the prevention agenda for HIV and other sexually transmitted infections in south China: social science research to inform effective public health interventions.
[So] Source:AIDS Behav;18 Suppl 2:S222-31, 2014 Feb.
[Is] ISSN:1573-3254
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite widespread biomedical advances in treatment and prevention, HIV and other sexually transmitted infections (STI) continue to affect a large portion of the world's population. The profoundly social nature of behaviorally driven epidemics and disparities across socioeconomic divides in the distribution of HIV/STI and care outcomes emphasize the need for innovative, multilevel interventions. Interdisciplinary approaches to HIV/STI control are needed to combine insights from the social and biological sciences and public health fields. In this concluding essay to a Special Issue on HIV/STI in south China, we describe the evolution of the region's HIV/STI epidemics and the government response, then synthesize findings from the 11 studies presented in this issue to extend seven recommendations for future HIV/STI prevention and care research in China. We discuss lessons learned from forging international collaborations between the social and biological sciences and public health to inform a shared research agenda to better meet the needs of those most affected by HIV and other STI.
[Mh] Termos MeSH primário: Doenças Sexualmente Transmissíveis/prevenção & controle
[Mh] Termos MeSH secundário: Pesquisa Biomédica
China/epidemiologia
Infecções por HIV/epidemiologia
Infecções por HIV/prevenção & controle
Humanos
Cooperação Internacional
Saúde Pública
Doenças Sexualmente Transmissíveis/epidemiologia
Ciências Sociais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140224
[St] Status:MEDLINE
[do] DOI:10.1007/s10461-014-0695-1


  2 / 20075 MEDLINE  
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[PMID]:24337698
[Au] Autor:Henderson G; Maman S; Huang Y; Muessig K; Pan S
[Ad] Endereço:Department of Social Medicine, University of North Carolina School of Medicine, 333 South Columbia St., 347 MacNider, Chapel Hill, NC, 27599-7240, USA, gail_henderson@med.unc.edu.
[Ti] Título:Social contexts of heterosexual transmission of HIV/STI in Liuzhou City, China.
[So] Source:AIDS Behav;18 Suppl 2:S111-7, 2014 Feb.
[Is] ISSN:1573-3254
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this special issue of AIDS and Behavior, we focus on the social contexts of sexual transmission of HIV/STI in one South China city. Our multiple projects grew from partnerships across the social and biomedical sciences, and with public health experts in Liuzhou City, to address critical gaps in knowledge about how social factors drive heterosexual transmission. The eleven articles that comprise this special issue feature multidisciplinary and mixed method approaches, collecting data in Liuzhou from different populations, environments, and social venues where individuals often find sexual partners. They document heterosexual behaviors and their meanings. They investigate the experiences and behaviors of women and men in social venues, exploring the networks of people within these venues, how they relate to one another, share information, and influence each other. The articles also examine the experiences of people living with HIV, again collecting data from multiple levels and sources, and revealing the ongoing power of stigma to shape these lives. Taken together, the articles demonstrate the critical role of social contexts in shaping behaviors and meanings, which are linked to heterosexual transmission of HIV/STI, and which must be taken into account for the development of appropriate and effective public health interventions.
[Mh] Termos MeSH primário: Infecções por HIV/transmissão
Heterossexualidade
Parceiros Sexuais
Meio Social
[Mh] Termos MeSH secundário: Feminino
Humanos
Masculino
Doenças Sexualmente Transmissíveis/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140224
[St] Status:MEDLINE
[do] DOI:10.1007/s10461-013-0666-y


  3 / 20075 MEDLINE  
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[PMID]:24174289
[Au] Autor:Huang Y; Abler L; Pan S; Henderson GE; Wang X; Yao X; Parish WL
[Ad] Endereço:Department of Sociology, Institute of Sexuality and Gender, Renmin University of China, Beijing, China.
[Ti] Título:Population-based sexual behavior surveys in China: Liuzhou compared with other prefectural cities.
[So] Source:AIDS Behav;18 Suppl 2:S118-25, 2014 Feb.
[Is] ISSN:1573-3254
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sexual behaviors in China are rapidly changing; simultaneously, sexually transmitted infections (STI)/HIV prevalence is increasing in the general population. To investigate these major shifts, we examined sexual behaviors and self-reported STI in one prefectural city in southern China, Liuzhou, and compared it to other prefectural cities throughout China. We used adults age 18-39 from two sets of population-based surveys that paralleled each other in both content and method. The first set was the Liuzhou survey conducted in 2008 (n = 398). The second set consisted of two national surveys collected in 2006 and 2010 (n = 2,186). Liuzhou respondents reported more active social and sexual behaviors than their national counterparts, including more socializing, dancing, drinking excessively, sexual activity among never married men and women, purchasing commercial sex among men, one-night stands among men, multiple sexual partnerships and self-reported STI among both men and women. Women in Liuzhou reported greater sexual risk behavior than their national counterparts, although overall they reported less than their male counterparts; they were also more likely to have had an abortion than women in other prefectural cities. Our findings provide a comprehensive overview of the sexual context of Liuzhou among the general population, which may help explain the greater STI/HIV prevalence in Liuzhou.
[Mh] Termos MeSH primário: Comportamento Sexual/estatística & dados numéricos
Parceiros Sexuais
Doenças Sexualmente Transmissíveis/prevenção & controle
População Urbana
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
China/epidemiologia
Feminino
Infecções por HIV/prevenção & controle
Conhecimentos, Atitudes e Prática em Saúde
Inquéritos Epidemiológicos
Humanos
Entrevistas como Assunto
Estilo de Vida
Modelos Logísticos
Masculino
Vigilância da População
Prevalência
Questionários
Assunção de Riscos
Distribuição por Sexo
Fatores Sexuais
Doenças Sexualmente Transmissíveis/epidemiologia
Fatores Socioeconômicos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140224
[St] Status:MEDLINE
[do] DOI:10.1007/s10461-013-0645-3


  4 / 20075 MEDLINE  
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[PMID]:23632897
[Au] Autor:Zhang N; Abler L; Bao Y; Pan S
[Ad] Endereço:Department of Sociology, Institute for Research on Sexuality and Gender, Renmin University of China, No. 59, Zhongguancun Street, Beijing, 100872, China, nanzhangkm@gmail.com.
[Ti] Título:Understanding the meaning of short-term, yiyeqing relationships and how they are formed: implications for condom use in Liuzhou, China.
[So] Source:AIDS Behav;18 Suppl 2:S126-34, 2014 Feb.
[Is] ISSN:1573-3254
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Yiyeqing (YYQ) ("one night love", i.e., having sex only once with a non-commercial partner) has increased in China, concomitant with the increase in heterosexual transmission of sexually transmitted infections/human immunodeficiency virus (STI/HIV). Our study explored how participants who had experienced YYQ understood these relationships and characterized YYQ's links to sexual risk behaviors. We conducted in-depth interviews with 45 adults in Liuzhou, a city in southwest China, who had YYQ experience. We analyzed the findings using social construction to interpret the participants' understandings of YYQ. Participants reported that they tend to select YYQ partners whom they trust, which is built through introductions from social connections and within entertainment venues, resulting in the belief that their partners are free of STI/HIV and do not require protected sex. As YYQ relationships become more common, understanding the nature of these relationships is critical for developing public health messages that convey the risks associated with sex in short-term relationships and the need for condoms.
[Mh] Termos MeSH primário: Preservativos/utilização
Assunção de Riscos
Comportamento Sexual
Parceiros Sexuais
Doenças Sexualmente Transmissíveis/prevenção & controle
Confiança
[Mh] Termos MeSH secundário: Adolescente
Adulto
China
Feminino
Humanos
Entrevistas como Assunto
Masculino
Meia-Idade
Pesquisa Qualitativa
Questionários
Fatores Socioeconômicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140224
[St] Status:MEDLINE
[do] DOI:10.1007/s10461-013-0489-x


  5 / 20075 MEDLINE  
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[PMID]:24188707
[Au] Autor:Romano J; Manning J; Hemmerling A; McGrory E; Holt BY
[Ad] Endereço:NWJ Group, LLC, USA. Electronic address: Jromano.nwjgroup@gmail.com.
[Ti] Título:Prioritizing multipurpose prevention technology development and investments using a target product profile.
[So] Source:Antiviral Res;100 Suppl:S32-8, 2013 Dec.
[Is] ISSN:1872-9096
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Multipurpose prevention technologies (MPTs) represent a powerful opportunity to address the unmet sexual and reproductive health needs of women in at-risk populations around the world in an efficient and cost-effective manner. The development of MPT products for the combination prevention of pregnancy and sexually transmitted infections (including HIV) is a high-risk/high-gain, expensive process. The associated challenges are compounded by limitations in available resources for the development, evaluation, and delivery of such products. Consequently, an objective process for identifying MPT products with the highest public health impact potential is necessary to serve as the basis of coordinated investment of supporting agencies in the development of such products. Moreover, this process would serve as a framework for product development organizations, guiding their product development strategies. The Scientific Agenda Working Group of the Initiative for Multipurpose Prevention Technologies conducted an MPT pipeline evaluation exercise for the purpose of defining specific MPT product priorities, and to identify MPT technology gaps which need to be addressed in order to achieve development of optimal products. Through a formal and objective process, a set of MPT priority product recommendations emerged, along with several priority MPT gaps. Further, specific MPT development process priorities were identified. The detailed process and summary findings of this exercise are presented here. This article is based on a presentation at the "Product Development Workshop 2013: HIV and Multipurpose Prevention Technologies," held in Arlington, Virginia on February 21-22, 2013. It forms part of a special supplement to Antiviral Research.
[Mh] Termos MeSH primário: Controle de Doenças Transmissíveis/métodos
Anticoncepção/métodos
Infecções por HIV/prevenção & controle
[Mh] Termos MeSH secundário: Controle de Doenças Transmissíveis/instrumentação
Anticoncepção/instrumentação
Feminino
Humanos
Masculino
Gravidez
Doenças Sexualmente Transmissíveis/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131203
[St] Status:MEDLINE


  6 / 20075 MEDLINE  
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[PMID]:23974714
[Au] Autor:Goyal MK; Mollen CJ; Hayes KL; Molnar J; Christian CW; Scribano PV; Lavelle J
[Ad] Endereço:From the *Children's National Medical Center, Washington, DC; †The George Washington University, ‡The Children's Hospital of Philadelphia, and §University of Pennsylvania School of Medicine, Philadelphia, PA.
[Ti] Título:Enhancing the emergency department approach to pediatric sexual assault care: implementation of a pediatric sexual assault response team program.
[So] Source:Pediatr Emerg Care;29(9):969-73, 2013 Sep.
[Is] ISSN:1535-1815
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The objectives of this study were to describe the experience of a novel pediatric sexual assault response team (SART) program in the first 3 years of implementation and compare patient characteristics, evaluation, and treatment among subpopulations of patients. METHODS: This was a retrospective chart review of a consecutive sample of patients evaluated at a pediatric emergency department (ED) who met institutional criteria for a SART evaluation. Associations of evaluation and treatment with sex, menarchal status, and presence of injuries were measured using logistic regression. RESULTS: One hundred eighty-four patients met criteria for SART evaluation, of whom 87.5% were female; mean age was 10.1 (SD, 4.6) years. The majority of patients underwent forensic evidence collection (89.1%), which varied by menarchal status among girls (P < 0.01), but not by sex. Evidence of acute anogenital injury on physical examination was found in 20.6% of patients. As per the Centers for Disease Control and Prevention guidelines for acute sexual assault evaluations in pediatric patients, menarchal girls were more likely to undergo testing for sexually transmitted infections and pregnancy (P < 0.01) and to be offered pregnancy, sexually transmitted infection, and HIV prophylaxis (P < 0.01). CONCLUSIONS: In an effort to improve quality and consistency of acute sexual assault examinations in a pediatric ED, development of a SART program supported the majority of eligible patients undergoing forensic evidence collection. Furthermore, a substantial number of patients had evidence of injury on examination. These findings underscore the importance of having properly trained personnel to support ED care for pediatric victims of acute sexual assault.
[Mh] Termos MeSH primário: Abuso Sexual na Infância
Serviço Hospitalar de Emergência/organização & administração
Equipe de Assistência ao Paciente/organização & administração
[Mh] Termos MeSH secundário: Adolescente
Canal Anal/lesões
Criança
Abuso Sexual na Infância/diagnóstico
Abuso Sexual na Infância/legislação & jurisprudência
Abuso Sexual na Infância/estatística & dados numéricos
Abuso Sexual na Infância/terapia
Pré-Escolar
Estudos Transversais
Emergências
Serviço Hospitalar de Emergência/utilização
Feminino
Medicina Legal/métodos
Genitália/lesões
Hospitais Pediátricos/organização & administração
Hospitais Urbanos/organização & administração
Humanos
Lactente
Masculino
Notificação de Abuso
Philadelphia/epidemiologia
Gravidez
Testes de Gravidez/utilização
Melhoria de Qualidade
Estudos Retrospectivos
Doenças Sexualmente Transmissíveis/diagnóstico
Doenças Sexualmente Transmissíveis/etiologia
Doenças Sexualmente Transmissíveis/prevenção & controle
Doenças Sexualmente Transmissíveis/terapia
Manejo de Espécimes
Ferimentos e Lesões/diagnóstico
Ferimentos e Lesões/etiologia
Ferimentos e Lesões/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131108
[St] Status:MEDLINE
[do] DOI:10.1097/PEC.0b013e3182a21a0d


  7 / 20075 MEDLINE  
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[PMID]:24998003
[Au] Autor:Lane R
[Ti] Título:Harold Jaffe: tireless proponent of better health for the USA.
[So] Source:Lancet;384(9937):15, 2014 Jul 5.
[Is] ISSN:1474-547X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Epidemias/história
Infecções por HIV/história
Liderança
Saúde Pública/tendências
[Mh] Termos MeSH secundário: Centers for Disease Control and Prevention (U.S.)
Reino Unido
Infecções por HIV/epidemiologia
História do Século XX
História do Século XXI
Homossexualidade Masculina
Humanos
Masculino
Saúde Pública/história
Doenças Sexualmente Transmissíveis/história
Estados Unidos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Jaffe H
[Em] Mês de entrada:1407
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:140707
[St] Status:MEDLINE


  8 / 20075 MEDLINE  
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[PMID]:24996590
[Au] Autor:Khabbaz RF; Moseley RR; Steiner RJ; Levitt AM; Bell BP
[Ad] Endereço:Office of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: rfk1@cdc.gov....
[Ti] Título:Challenges of infectious diseases in the USA.
[So] Source:Lancet;384(9937):53-63, 2014 Jul 5.
[Is] ISSN:1474-547X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the USA, infectious diseases continue to exact a substantial toll on health and health-care resources. Endemic diseases such as chronic hepatitis, HIV, and other sexually transmitted infections affect millions of individuals and widen health disparities. Additional concerns include health-care-associated and foodborne infections--both of which have been targets of broad prevention efforts, with success in some areas, yet major challenges remain. Although substantial progress in reduction of the burden of vaccine-preventable diseases has been made, continued cases and outbreaks of these diseases persist, driven by various contributing factors. Worldwide, emerging and reemerging infections continue to challenge prevention and control strategies while the growing problem of antimicrobial resistance needs urgent action. An important priority for control of infectious disease is to ensure that scientific and technological advances in molecular diagnostics and bioinformatics are well integrated into public health. Broad and diverse partnerships across governments, health care, academia, and industry, and with the public, are essential to effectively reduce the burden of infectious diseases.
[Mh] Termos MeSH primário: Controle de Doenças Transmissíveis
Doenças Transmissíveis/epidemiologia
Saúde Pública
[Mh] Termos MeSH secundário: Animais
Controle de Doenças Transmissíveis/métodos
Vetores de Doenças
Resistência Microbiana a Medicamentos
Infecções por HIV/epidemiologia
Infecções por HIV/prevenção & controle
Hepatite Crônica/epidemiologia
Hepatite Crônica/prevenção & controle
Humanos
Incidência
Prevalência
Saúde Pública/normas
Saúde Pública/tendências
Doenças Sexualmente Transmissíveis/epidemiologia
Doenças Sexualmente Transmissíveis/prevenção & controle
Tuberculose/epidemiologia
Tuberculose/prevenção & controle
Estados Unidos/epidemiologia
Vacinação
Zoonoses/epidemiologia
Zoonoses/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1407
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:140707
[St] Status:MEDLINE


  9 / 20075 MEDLINE  
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[PMID]:24403560
[Au] Autor:Doerflinger SY; Throop AL; Herbst-Kralovetz MM
[Ad] Endereço:Human and Molecular Biology Center, Saarland University, Saarbrucken, Germany Department of Basic Medical Sciences, College of Medicine-Phoenix, University of Arizona.
[Ti] Título:Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner.
[So] Source:J Infect Dis;209(12):1989-99, 2014 Jun 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bacterial vaginosis increases the susceptibility to sexually transmitted infections and negatively affects women's reproductive health. METHODS: To investigate host-vaginal microbiota interactions and the impact on immune barrier function, we colonized 3-dimensional (3-D) human vaginal epithelial cells with 2 predominant species of vaginal microbiota (Lactobacillus iners and Lactobacillus crispatus) or 2 prevalent bacteria associated with bacterial vaginosis (Atopobium vaginae and Prevotella bivia). RESULTS: Colonization of 3-D vaginal epithelial cell aggregates with vaginal microbiota was observed with direct attachment to host cell surface with no cytotoxicity. A. vaginae infection yielded increased expression membrane-associated mucins and evoked a robust proinflammatory, immune response in 3-D vaginal epithelial cells (ie, expression of CCL20, hBD-2, interleukin 1ß, interleukin 6, interleukin 8, and tumor necrosis factor α) that can negatively affect barrier function. However, P. bivia and L. crispatus did not significantly upregulate pattern-recognition receptor-signaling, mucin expression, antimicrobial peptides/defensins, or proinflammatory cytokines in 3-D vaginal epithelial cell aggregates. Notably, L. iners induced pattern-recognition receptor-signaling activity, but no change was observed in mucin expression or secretion of interleukin 6 and interleukin 8. CONCLUSIONS: We identified unique species-specific immune signatures from vaginal epithelial cells elicited by colonization with commensal and bacterial vaginosis-associated bacteria. A. vaginae elicited a signature that is consistent with significant disruption of immune barrier properties, potentially resulting in enhanced susceptibility to sexually transmitted infections during bacterial vaginosis.
[Mh] Termos MeSH primário: Células Epiteliais/microbiologia
Imunidade Inata
Lactobacillus/imunologia
Microbiota
Vagina/microbiologia
[Mh] Termos MeSH secundário: Actinobacteria/imunologia
Actinobacteria/isolamento & purificação
Peptídeos Catiônicos Antimicrobianos/metabolismo
Células Epiteliais/imunologia
Epitélio/imunologia
Epitélio/microbiologia
Feminino
Humanos
Interleucina-1beta/metabolismo
Interleucina-1beta/secreção
Interleucina-6/metabolismo
Interleucina-6/secreção
Interleucina-8/metabolismo
Interleucina-8/secreção
Lactobacillus/isolamento & purificação
Mucinas/genética
Mucinas/metabolismo
Provotella/imunologia
Provotella/isolamento & purificação
Doenças Sexualmente Transmissíveis/imunologia
Doenças Sexualmente Transmissíveis/prevenção & controle
Especificidade da Espécie
Vagina/citologia
Vagina/imunologia
Vaginose Bacteriana/imunologia
Vaginose Bacteriana/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antimicrobial Cationic Peptides); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Interleukin-8); 0 (Mucins)
[Em] Mês de entrada:1407
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:140530
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jiu004


  10 / 20075 MEDLINE  
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[PMID]:23870458
[Au] Autor:Mackern-Oberti JP; Motrich RD; Breser ML; Sánchez LR; Cuffini C; Rivero VE
[Ad] Endereço:Centro de Investigaciones en Bioquímica Clínica e Inmunología. CIBICI-CONICET Argentina.
[Ti] Título:Chlamydia trachomatis infection of the male genital tract: an update.
[So] Source:J Reprod Immunol;100(1):37-53, 2013 Nov.
[Is] ISSN:1872-7603
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Chlamydia trachomatis (CT) is the most prevalent cause of sexually transmitted diseases. Although the prevalence of chlamydial infection is similar in men and women, current research and screening are still focused on women, who develop the most severe complications, leaving the study of male genital tract (MGT) infection underrated. Herein, we reviewed the literature on genital CT infection with special focus on the MGT. Data indicate that CT certainly infects different parts of the MGT such as the urethra, seminal vesicles, prostate, epididymis and testis. However, whether or not CT infection has detrimental effects on male fertility is still controversial. The most important features of CT infection are its chronic nature and the presence of a mild inflammation that remains subclinical in most individuals. Chlamydia antigens and pathogen recognition receptors (PRR), expressed on epithelial cells and immune cells from the MGT, have been studied in the last years. Toll-like receptor (TLR) expression has been observed in the testis, epididymis, prostate and vas deferens. It has been demonstrated that recognition of chlamydial antigens is associated with TLR2, TLR4, and possibly, other PRRs. CT recognition by PRRs induces a local production of cytokines/chemokines, which, in turn, provoke chronic inflammation that might evolve in the onset of an autoimmune process in genetically susceptible individuals. Understanding local immune response along the MGT, as well as the crosstalk between resident leukocytes, epithelial, and stromal cells, would be crucial in inducing a protective immunity, thus adding to the design of new therapeutic approaches to a Chlamydia vaccine.
[Mh] Termos MeSH primário: Infecções por Chlamydia/imunologia
Chlamydia trachomatis/imunologia
Genitália Masculina/metabolismo
Imunoterapia
Infertilidade/imunologia
Doenças Sexualmente Transmissíveis/imunologia
[Mh] Termos MeSH secundário: Antígenos de Bactérias/imunologia
Autoimunidade
Infecções por Chlamydia/terapia
Feminino
Genitália Masculina/imunologia
Genitália Masculina/microbiologia
Humanos
Imunidade Inata
Infertilidade/terapia
Mediadores da Inflamação/metabolismo
Masculino
Receptores de Reconhecimento de Padrão/metabolismo
Doenças Sexualmente Transmissíveis/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antigens, Bacterial); 0 (Inflammation Mediators); 0 (Receptors, Pattern Recognition)
[Em] Mês de entrada:1407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131104
[St] Status:MEDLINE



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