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Pesquisa : Doenças and Sexualmente and Transmissíveis [Palavras]
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  1 / 20424 MEDLINE  
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[PMID]:25211749
[Au] Autor:Crosby RA; Charnigo RJ; Salazar LF; Pasternak R; Terrell IW; Ricks J; Smith RV; Taylor SN
[Ad] Endereço:Richard A. Crosby, Richard J. Charnigo, and Rachel V. Smith are with the College of Public Health, University of Kentucky, Lexington. Laura F. Salazar is with the Institute of Public Health, Georgia State University, Atlanta. Ryan Pasternak and Ivy Terrell are with the Health Sciences Center, and Stephanie N. Taylor is with the Delgado Personal Health Center STD Clinic, Louisiana State University, New Orleans. JaNelle Ricks is with the Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atlanta, GA.
[Ti] Título:Enhancing condom use among Black male youths: a randomized controlled trial.
[So] Source:Am J Public Health;104(11):2219-25, 2014 Nov.
[Is] ISSN:1541-0048
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We tested the efficacy of a brief intervention to promote correct and consistent use of condoms among Black male youths attending sexually transmitted infection (STI) clinics in 3 southern US cities. METHODS: In 2010 to 2012, we screened (n = 1102) and enrolled (n = 702) youths aged 15 to 23 years who identified as Black and reported recent (past 2 months) sexual activity and randomized them to a private, brief, interactive intervention (n = 349) or an attention-equivalent control condition (n = 353). Assessments occurred at baseline and 2 and 6 months after the intervention. RESULTS: At 6 months, with adjustment for age and pretest nonequivalence of the outcome variable, an estimated odds ratio (EOR) of 1.63 (95% confidence interval [CI] = 1.07, 2.49; P = .02) indicated efficacy for correct condom use. An adjusted generalized estimating equations model with both 2- and 6-month condom use variables produced an EOR of 1.49 (95% CI = 1.06, 2.08; P = .02). We did not observe significant effects on chlamydia and gonorrhea incidence. CONCLUSIONS: This brief intervention, delivered as part of STI clinical care, could help alleviate the disproportionate STI-HIV burden among young Black men.
[Mh] Termos MeSH primário: Afro-Americanos/psicologia
Preservativos/utilização
Promoção da Saúde/métodos
[Mh] Termos MeSH secundário: Adolescente
Afro-Americanos/estatística & dados numéricos
Educação em Saúde/métodos
Humanos
Louisiana/epidemiologia
Masculino
North Carolina/epidemiologia
Doenças Sexualmente Transmissíveis/prevenção & controle
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1412
[Cu] Atualização por classe:150117
[Lr] Data última revisão:
150117
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:141009
[St] Status:MEDLINE
[do] DOI:10.2105/AJPH.2014.302131


  2 / 20424 MEDLINE  
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[PMID]:24428236
[Au] Autor:Braithwaite RS; Nucifora KA; Kessler J; Toohey C; Mentor SM; Uhler LM; Roberts MS; Bryant K
[Ad] Endereço:Department of Population Health, New York University School of Medicine, New York, New York.
[Ti] Título:Impact of interventions targeting unhealthy alcohol use in Kenya on HIV transmission and AIDS-related deaths.
[So] Source:Alcohol Clin Exp Res;38(4):1059-67, 2014 Apr.
[Is] ISSN:1530-0277
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: HIV remains a major cause of preventable morbidity and mortality in Kenya. The effects of behaviors that accompany unhealthy alcohol consumption are a pervasive risk factor for HIV transmission and progression. Our objective was to estimate the portion of HIV infections attributable to unhealthy alcohol use and to evaluate the impact of hypothetical interventions directed at unhealthy alcohol use on HIV infections and deaths. METHODS: We estimated outcomes over a time horizon of 20 years using a computer simulation of the Kenyan population. This computer simulation integrates a compartmental model of HIV transmission with a mechanistic model of HIV progression that was previously validated in sub-Saharan Africa. Integration of the transmission and progression models allows simultaneous consideration of alcohol's effects on HIV transmission and progression (e.g., lowering antiretroviral adherence may increase transmission risk by elevating viral load, and may simultaneously increase progression by increasing the likelihood of AIDS). The simulation considers important aspects of heterogeneous sexual mixing patterns, including assortativeness of partners by age and activity level, age-discordant relationships, and high activity subgroups. Outcomes included number of new HIV infections, number of AIDS deaths, and infectivity (number of new infections per infected person per year). RESULTS: Our model estimated that the effects of behaviors accompanying unhealthy alcohol consumption are responsible for 13.0% of new HIV infections in Kenya. An alcohol intervention with effectiveness similar to that observed in a published randomized controlled trial of a cognitive-behavioral therapy-based intervention in Kenya (45% reduction in unhealthy alcohol consumption) could prevent nearly half of these infections, reducing their number by 69,858 and reducing AIDS deaths by 17,824 over 20 years. Estimates were sensitive to assumptions with respect to the magnitude of alcohol's underlying effects on condom use, antiretroviral therapy adherence, and sexually transmitted infection prevalence. CONCLUSIONS: A substantial number of new HIV infections in Kenya are attributable to unhealthy alcohol use. An alcohol intervention with the effectiveness observed in a published randomized controlled trial has the potential to reduce infections over 20 years by nearly 5% and avert nearly 18,000 deaths related to HIV.
[Mh] Termos MeSH primário: Síndrome de Imunodeficiência Adquirida/mortalidade
Síndrome de Imunodeficiência Adquirida/transmissão
Alcoolismo/epidemiologia
Simulação por Computador
HIV-1
Assunção de Riscos
[Mh] Termos MeSH secundário: Alcoolismo/prevenção & controle
Simulação por Computador/tendências
Feminino
Infecções por HIV/mortalidade
Infecções por HIV/transmissão
Humanos
Quênia/epidemiologia
Masculino
Fatores de Risco
Doenças Sexualmente Transmissíveis/mortalidade
Doenças Sexualmente Transmissíveis/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1412
[Cu] Atualização por classe:150116
[Lr] Data última revisão:
150116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140410
[St] Status:MEDLINE
[do] DOI:10.1111/acer.12332


  3 / 20424 MEDLINE  
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[PMID]:25137847
[Au] Autor:Zhang Y; Ma JP; Ma XL; Zeng L; Abudureyimu A; Li JR
[Ti] Título:[Analysis of tongue figure features in 990 cases of sexually transmitted and intravenous drug use spread HIV infected population in Xinjiang].
[So] Source:Zhongguo Zhong Xi Yi Jie He Za Zhi;34(7):816-8, 2014 Jul.
[Is] ISSN:1003-5370
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the tongue manifestation features of sexually transmitted and intravenous drug use spread HIV infected population in Xinjiang. METHODS: Recruited were 990 HIV infected subjects in Xinjiang from May 2011 to March 2012, who were assigned to the intravenous drug use spread HIV infected (498 cases) and the sexually transmitted (492 cases). By using tongue figure shoot combined with analyses of experts, tongue manifestations were analyzed and compared between the sexually transmitted and the intravenous drug use spread from four aspects, i.e., the tongue color, the tongue shape, the fur color, and the fur property. RESULTS: Compared with the sexually transmitted population, red tongue, fissured tongue, yellow fur, thick fur, eroded fur, deficiency of fur fluid were more often seen, showing statistical difference (P < 0.05). Compared with the intravenous drug use spread population, pale tongue, white fur, and thin fur were more often seen, showing statistical difference (P < 0.05). CONCLUSIONS: The tongue manifestations of the intravenous drug use spread HIV population reflected inner exuberance of evil toxin and heat impairing qi and yin. Compared with the intravenous drug use spread population, the attack of HIV infection was more hiding in the sexually transmitted population, with milder internal injury. Their Wei-qi was not damaged and no obvious change occurred in the tongue figure.
[Mh] Termos MeSH primário: Infecções por HIV/patologia
Medicina Tradicional Chinesa
Língua/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Infecções por HIV/diagnóstico
Infecções por HIV/etiologia
Humanos
Masculino
Meia-Idade
Doenças Virais Sexualmente Transmissíveis/diagnóstico
Doenças Virais Sexualmente Transmissíveis/patologia
Transtornos Relacionados ao Uso de Substâncias/complicações
Transtornos Relacionados ao Uso de Substâncias/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140820
[St] Status:MEDLINE


  4 / 20424 MEDLINE  
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[PMID]:24844845
[Au] Autor:Riess TH; Achieng' MM; Bailey RC
[Ad] Endereço:School of Public Health, University of Illinois at Chicago, Chicago, Illinois, United States of America.
[Ti] Título:Women's beliefs about male circumcision, HIV prevention, and sexual behaviors in Kisumu, Kenya.
[So] Source:PLoS One;9(5):e97748, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is important to understand how women's sexual practices may be influenced by male circumcision (MC) as an HIV prevention effort. Women's beliefs about MC and sexual behaviour will likely influence the scale-up and uptake of medical MC. We conducted qualitative interviews with 30 sexually active women in Kisumu, Kenya. Women discussed MC related to perceived health benefits, condom use, sexual behaviour, knowledge of susceptibility to HIV and sexually transmitted infections (STIs), circumcision preference, and influence on circumcision uptake. Respondents had a good understanding of the partial protection of MC for acquisition of HIV for men. Women perceived circumcised men as cleaner, carrying fewer diseases, and taking more time to reach ejaculation. Male's circumcision status is a salient factor for women's sexual decision making, including partner choice, and condom use. It will be important that educational information affirms that MC provides only partial protection against female to male transmission of HIV and some STIs; that other HIV and STI prevention methods such as condoms need to be used in conjunction with MC; that MC does not preclude a man from having HIV; and that couples should develop plans for not having sex while the man is healing.
[Mh] Termos MeSH primário: Circuncisão Masculina
Cultura
Infecções por HIV/prevenção & controle
Conhecimentos, Atitudes e Prática em Saúde
Comportamento Sexual
[Mh] Termos MeSH secundário: Adulto
Preservativos
Feminino
Infecções por HIV/transmissão
Inquéritos Epidemiológicos
Humanos
Quênia
Masculino
Questionários
Sexo Seguro
Doenças Sexualmente Transmissíveis/prevenção & controle
Doenças Sexualmente Transmissíveis/transmissão
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Em] Mês de entrada:1501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140521
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0097748


  5 / 20424 MEDLINE  
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[PMID]:25346379
[Au] Autor:Wright PB; Booth BM; Curran GM; Borders TF; Ounpraseuth ST; Stewart KE
[Ad] Endereço:College of Nursing, University of Arkansas for Medical Sciences, 4301 W. Markham, Slot 529, Little Rock, AR, 72205.
[Ti] Título:Correlates of HIV testing among rural African American cocaine users.
[So] Source:Res Nurs Health;37(6):466-77, 2014 Dec.
[Is] ISSN:1098-240X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Andersen's Revised Behavioral Model of Health Services Use (RBM) was used as a framework in this correlational cross-sectional study to examine factors associated with HIV testing among a sample of 251 rural African American cocaine users. All participants reported using cocaine and being sexually active within the past 30 days. Independent variables were categorized according to the RBM as predisposing, enabling, need, or health behavior factors. Number of times tested for HIV (never, one time, two to four times, five or more times) was the outcome of interest. In ordered logistic regression analyses, HIV testing was strongly associated with being female, of younger age (predisposing factors); having been tested for sexually transmitted diseases or hepatitis, ever having been incarcerated in jail or prison (enabling factors); and having had one sex partner the past 30 days (health behavior factor). Other sexual risk behaviors, drug use, health status, and perception of risk were not associated with HIV testing. Our findings confirm the importance of routine testing in all healthcare settings rather than risk-based testing.
[Mh] Termos MeSH primário: Afro-Americanos/estatística & dados numéricos
Transtornos Relacionados ao Uso de Cocaína/epidemiologia
Infecções por HIV/diagnóstico
Infecções por HIV/epidemiologia
Doenças Virais Sexualmente Transmissíveis/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Arkansas/epidemiologia
Feminino
Humanos
Masculino
Meia-Idade
Fatores de Risco
População Rural
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1501
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:141114
[St] Status:MEDLINE
[do] DOI:10.1002/nur.21629


  6 / 20424 MEDLINE  
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[PMID]:24981418
[Au] Autor:Ward J; Goller J; Ali H; Bowring A; Couzos S; Saunders M; Yau P; Kaldor JM; Hellard M; Guy RJ; Donovan B; ACCESS Collaboration
[Ad] Endereço:Baker IDI Heart and Diabetes Institute, Alice Springs 0871 NT, Australia. James.Ward@bakeridi.edu.au.
[Ti] Título:Chlamydia among Australian Aboriginal and/or Torres Strait Islander people attending sexual health services, general practices and Aboriginal community controlled health services.
[So] Source:BMC Health Serv Res;14:285, 2014.
[Is] ISSN:1472-6963
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chlamydia infections are notified at much higher rates in Aboriginal and/or Torres Strait Islander people compared to non-Indigenous people. The Australian Collaboration Chlamydia Enhanced Sentinel Surveillance System (ACCESS) was established to complement population-based surveillance. METHODS: We describe patient demographics, completeness of recording of Aboriginal and/or Torres Strait Islander ('Aboriginal') status, chlamydia testing rates and positivity rates from the Aboriginal Community Controlled Health Service (ACCHSs), General Practice (GP) clinics and Sexual Health Services (SHSs) networks in ACCESS during 2009. Data were extracted from electronic medical records of each participating health service for consultations with patients aged 16-29 years and for chlamydia testing and positivity. RESULTS: Data were included from 16-29 year olds attending six ACCHSs (n = 4,950); 22 SHSs (n = 20,691) and 25 GP clinics (n = 34,462). Aboriginal status was unknown for 79.3% of patients attending GP clinics, 4.5% attending SHSs and 3.8% of patients attending ACCHSs. Chlamydia testing rates among Aboriginal patients were 19.8% (95%CI:18.6%-21.0%) at ACCHSs, 75.5% (95% CI:72.5%-78.4%) at SHSs and 4.3% (95% CI: 2.6%-6.6%) at GP clinics. Positivity rates were highest in Aboriginal patients tested at SHSs at 22.7% (95% CI:19.5%-26.2%), followed by 15.8% (95% CI:3.8%-43.4%) at GP clinics and 8.6% at ACCHSs (95% CI:7.9%-12.4%). This compared with non-Indigenous patients positivity rates at SHSs of 12.7% (95% CI:12.2-13.2%); 8.6% (7.2%-11.3%) at GP clinics and 11.3% at ACCHSs (95% CI:15.4%-24.9%). CONCLUSIONS: Higher chlamydia positivity in Aboriginal people across a range of clinical services is reflected in national notification data. Targeted efforts are required to improve testing rates in primary care services; to improve identification of Aboriginal patients in mainstream services such as GP clinics; and to better engage with young Aboriginal Australians.
[Mh] Termos MeSH primário: Infecções por Chlamydia/epidemiologia
Grupo com Ancestrais Oceânicos
Doenças Bacterianas Sexualmente Transmissíveis/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Austrália/epidemiologia
Feminino
Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140712
[St] Status:MEDLINE
[do] DOI:10.1186/1472-6963-14-285


  7 / 20424 MEDLINE  
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[PMID]:25417359
[Au] Autor:Bally F; Quach A
[Ti] Título:[Chlamydia: from population screening to individual repeated screening].
[Ti] Título:Chlamydia: du dépistage de la population au dépistage individuel répété..
[So] Source:Rev Med Suisse;10(445):1882, 1884-6, 2014 Oct 8.
[Is] ISSN:1660-9379
[Cp] País de publicação:Switzerland
[La] Idioma:fre
[Ab] Resumo:Chlamydia trachomatis is a frequent sexually transmitted infection especially in young adults and adolescents. Its complications can impair a woman's reproductive potential. chlamydia control has several challenges. These include asymptomatic infections; a long duration of untreated infections; re-infections and partner treatments. Any person with infection is at high risk of re-infection. Repeated screening would decrease, at an individual level, the risk of complications. General practitioners, gynaecologists and centres for sexual health could participate in Chlamydia screening for asymptomatic infections, in Switzerland, the cost of the laboratory test is fixed by national tariff regulations. The cost is high and prohibitive for many, especially adolescents and young adults and needs to be lowered.
[Mh] Termos MeSH primário: Infecções por Chlamydia/diagnóstico
Chlamydia
Programas de Rastreamento
[Mh] Termos MeSH secundário: Adolescente
Adulto
Chlamydia/isolamento & purificação
Infecções por Chlamydia/economia
Infecções por Chlamydia/epidemiologia
Feminino
Humanos
Programas de Rastreamento/economia
Programas de Rastreamento/métodos
Recidiva
Doenças Bacterianas Sexualmente Transmissíveis/diagnóstico
Doenças Bacterianas Sexualmente Transmissíveis/economia
Doenças Bacterianas Sexualmente Transmissíveis/epidemiologia
Suíça/epidemiologia
Infecções Urinárias/diagnóstico
Infecções Urinárias/economia
Infecções Urinárias/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141124
[St] Status:MEDLINE


  8 / 20424 MEDLINE  
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[PMID]:24824757
[Au] Autor:Igras SM; Macieira M; Murphy E; Lundgren R
[Ad] Endereço:a Institute for Reproductive Health , Georgetown University , Washington , DC , USA.
[Ti] Título:Investing in very young adolescents' sexual and reproductive health.
[So] Source:Glob Public Health;9(5):555-69, 2014.
[Is] ISSN:1744-1706
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Very young adolescents (VYAs) between the ages of 10 and 14 represent about half of the 1.2 billion adolescents aged 10-19 in the world today. In lower- and middle-income countries, where most unwanted pregnancies, unsafe abortions, maternal deaths and sexually transmitted infections occur, investment in positive youth development to promote sexual and reproductive health (SRH) is increasing. Most interventions, though, focus on older adolescents, overlooking VYAs. Since early adolescence marks a critical transition between childhood and older adolescence and adulthood, setting the stage for future SRH and gendered attitudes and behaviours, targeted investment in VYAs is imperative to lay foundations for healthy future relationships and positive SRH. This article advocates for such investments and identifies roles that policy-makers, donors, programme designers and researchers and evaluators can play to address the disparity.
[Mh] Termos MeSH primário: Países em Desenvolvimento
Serviços de Saúde Reprodutiva/organização & administração
Saúde Reprodutiva
Comportamento Sexual
[Mh] Termos MeSH secundário: Adolescente
Criança
Feminino
Redução do Dano
Política de Saúde
Humanos
Masculino
Gravidez
Gravidez não Desejada
Doenças Sexualmente Transmissíveis/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140529
[St] Status:MEDLINE
[do] DOI:10.1080/17441692.2014.908230


  9 / 20424 MEDLINE  
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[PMID]:24726714
[Au] Autor:Ott MA
[Ad] Endereço:Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
[Ti] Título:Vulnerability in HIV prevention research with adolescents, reconsidered.
[So] Source:J Adolesc Health;54(6):629-30, 2014 Jun.
[Is] ISSN:1879-1972
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anti-Infecciosos/administração & dosagem
Medicina Baseada em Evidências/métodos
Infecções por HIV/epidemiologia
Sujeitos da Pesquisa/estatística & dados numéricos
Comportamento Sexual/estatística & dados numéricos
Doenças Sexualmente Transmissíveis/epidemiologia
[Mh] Termos MeSH secundário: Feminino
Humanos
Gravidez
[Pt] Tipo de publicação:COMMENT; EDITORIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Anti-Infective Agents)
[Em] Mês de entrada:1501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140526
[St] Status:MEDLINE


  10 / 20424 MEDLINE  
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[PMID]:24690188
[Au] Autor:Schenk KD; Friedland BA; Chau M; Stoner M; Plagianos MG; Skoler-Karpoff S; Palanee T; Ahmed K; Rathlagana MJ; Mthembu PN; Ngcozela N
[Ad] Endereço:Population Council, Washington, DC....
[Ti] Título:Enrollment of adolescents aged 16-17 years old in microbicide trials: an evidence-based approach.
[So] Source:J Adolesc Health;54(6):654-62, 2014 Jun.
[Is] ISSN:1879-1972
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This article explores the ethics and feasibility of enrolling adolescent females in microbicide trials using data from 16- to 17-year-old participants of the Phase 3 trial of the candidate vaginal microbicide, Carraguard. METHODS: Secondary analysis was conducted to compare health, behavioral, and operational outcomes between 16- to 17-year-olds and 18- to 19-year-olds screened for and enrolled in the trial. Analytical approaches included Kaplan-Meier survival analysis, Cox proportional hazards modeling, and generalized estimating equations for nonsurvival end points. RESULTS: Results reveal no significant differences between the two age groups for health (sexually transmitted infection, adverse event), risk behavior, or operational (adherence, follow-up) outcomes. However, data suggest that after 1 year of trial participation, human immunodeficiency virus (HIV) and pregnancy incidence were higher and increased more rapidly for the 16- to 17-year-olds than for 18- to 19-year-olds; this finding is entirely consistent with other incidence data for HIV infection among South African youth and cannot be attributed to study participation without a comparison outside the trial. CONCLUSIONS: Data from the Carraguard trial provide no evidence that inclusion of 16- to 17-year-olds in the trial had any detrimental effect on trial participants or on the conduct of research. These data provide an argument motivating the inclusion of sexually active adolescents aged 16-17 years into future trials in order to avoid delaying access to an effective product for adolescents at high risk of HIV acquisition. Careful support for adolescent-inclusive protocols (including appropriate counseling) must be incorporated into study design.
[Mh] Termos MeSH primário: Anti-Infecciosos/administração & dosagem
Medicina Baseada em Evidências/métodos
Infecções por HIV/epidemiologia
Sujeitos da Pesquisa/estatística & dados numéricos
Comportamento Sexual/estatística & dados numéricos
Doenças Sexualmente Transmissíveis/epidemiologia
[Mh] Termos MeSH secundário: Administração Intravaginal
Adolescente
Comportamento do Adolescente
Adulto
Fatores Etários
Medicina Baseada em Evidências/ética
Estudos de Viabilidade
Feminino
Humanos
Estimativa de Kaplan-Meier
Seleção de Pacientes/ética
Gravidez
Gravidez na Adolescência/estatística & dados numéricos
Modelos de Riscos Proporcionais
Assunção de Riscos
África do Sul/epidemiologia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE III; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Anti-Infective Agents)
[Em] Mês de entrada:1501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140526
[St] Status:MEDLINE



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