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[PMID]:29465600
[Au] Autor:Ryu C; Boffa D; Bramley K; Pisani M; Puchalski J
[Ad] Endereço:Yale School of Medicine, Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine.
[Ti] Título:A novel endobronchial approach to massive hemoptysis complicating silicone Y-stent placement for tracheobronchomalacia: A case report.
[So] Source:Medicine (Baltimore);97(8):e9980, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Airway stabilization for severe, symptomatic tracheobronchomalacia (TBM) may be accomplished by silicone Y-stent placement. Common complications of the Y-stent include mucus plugging and granulation tissue formation. PATIENT CONCERNS: We describe a rare case of massive hemoptysis originating from a silicone Y-stent placed for TBM. DIAGNOSES: An emergent bronchoscopy showed an actively bleeding, pulsatile vessel at the distal end of the left bronchial limb of the Y-stent. It was felt that the bleeding was caused by, or at least impacted by, the distal left bronchial limb of the Y-stent eroding into the airway wall. INTERVENTIONS: We hypothesized that placement of oxidized regenerated cellulose (ORC) would provide initial hemostasis, and the subsequent placement of a biocompatible surgical sealant would lead to definitive resolution. OUTCOMES: ORC provided sufficient hemostasis and the subsequent synthetic polymer reinforced the tissue for complete cessation of the bleed. LESSONS: The combined use of ORC and a biocompatible surgical sealant provided long-term management for life-threatening hemoptysis, and potentially morbid procedures such as embolization or surgery were avoided by advanced endobronchial therapy.
[Mh] Termos MeSH primário: Broncoscopia/métodos
Hemoptise/cirurgia
Hemostase Endoscópica/métodos
Stents/efeitos adversos
Traqueobroncomalácia/cirurgia
[Mh] Termos MeSH secundário: Idoso
Celulose Oxidada/administração & dosagem
Feminino
Hemoptise/etiologia
Hemostáticos/administração & dosagem
Seres Humanos
Implante de Prótese/instrumentação
Implante de Prótese/métodos
Silicones
Traqueobroncomalácia/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cellulose, Oxidized); 0 (Hemostatics); 0 (Silicones)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009980


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[PMID]:29291277
[Au] Autor:Ahmad I; Kirby P; Liming B
[Ad] Endereço:1 Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
[Ti] Título:Ectopic Thymic Cyst of the Subglottis: Considerations for Diagnosis and Management.
[So] Source:Ann Otol Rhinol Laryngol;127(3):200-204, 2018 Mar.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To share the diagnostic and management challenges created by an extremely rare airway lesion-the subglottic ectopic thymic cyst. STUDY DESIGN: Case report and literature review. METHODS: We review the presentation, management, and clinical course of an infant who presented with a subglottic mass that was histologically confirmed as a thymic cyst. A brief literature review supplements the case presentation Results: We present the third described case of an ectopic thymic cyst presenting as a subglottic mass. The differential diagnosis of subglottic masses in neonates consists primarily of subglottic hemangioma and mucous retention cysts. Otolaryngologists must be prepared for unexpected findings when dealing with critical airways. We compare the presentation and management of our patient with the 2 previously described cases. We propose an embryologic theory for the origin of these rare lesions. CONCLUSIONS: An ectopic thymic cyst is a rare and unexpected cause of neonatal stridor. Management of pediatric airway lesions must allow for unexpected findings at the time of diagnostic and therapeutic endoscopy. The appropriate management of subglottic thymic cysts is poorly defined, but close surveillance for recurrence is mandatory.
[Mh] Termos MeSH primário: Anormalidades Congênitas/diagnóstico
Doenças da Laringe
Laringoscopia/métodos
Laringe/anormalidades
Cisto Mediastínico
Sons Respiratórios/diagnóstico
[Mh] Termos MeSH secundário: Coristoma
Anormalidades Congênitas/etiologia
Diagnóstico Diferencial
Seres Humanos
Lactente
Doenças da Laringe/diagnóstico
Doenças da Laringe/fisiopatologia
Masculino
Sons Respiratórios/etiologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417749609


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[PMID]:28468151
[Au] Autor:Pickrell BB; Meaike JD; Cañadas KT; Chandy BM; Buchanan EP
[Ad] Endereço:*Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine †Department of Otolaryngology, Texas Children's Hospital, Houston, TX.
[Ti] Título:Tracheal Cartilaginous Sleeve in Syndromic Craniosynostosis: An Underrecognized Source of Significant Morbidity and Mortality.
[So] Source:J Craniofac Surg;28(3):696-699, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tracheal cartilaginous sleeve (TCS) is a rare and previously unrecognized source of morbidity and mortality in patients with certain craniosynostosis syndromes. There is a paucity of reporting on this airway anomaly, and the true incidence of TCS is largely unknown. The purpose of this study was to investigate the incidence of TCS among patients with syndromic craniosynostosis at our institution. Patients with syndromic craniosynostosis who underwent direct bronchoscopy and laryngoscopy were evaluated retrospectively by pediatric otolaryngologists for the presence of TCS and associated anomalies. Among patients with a diagnosis of syndromic craniosynostosis in our craniofacial database, 10 (37%) were found to have previous direct bronchoscopy and laryngoscopy reports. Of these 10 patients, 2 had Crouzon syndrome, 3 had Pfeiffer syndrome, 3 had Apert syndrome, 1 had Muenke syndrome, and 1 had Antley-Bixler syndrome. Eighty percent (8/10) of these patients were found to have some evidence of TCS. The most commonly observed associated findings included the following: tracheostomy dependency (7/10; 70%), hearing loss (6/10; 60%), obstructive sleep apnea (5/10; 50%), cervical spine anomalies (5/10; 50%), developmental delay (5/10; 50%), and enlarged cerebral ventricles (4/10; 40%). Larger multicenter studies are required to further characterize this airway anomaly and its impact on this patient population. Our results confirm the importance of thorough airway evaluation at initial presentation and the need for validated screening protocols.
[Mh] Termos MeSH primário: Anormalidades Múltiplas
Cartilagem/anormalidades
Craniossinostoses/diagnóstico
Apneia Obstrutiva do Sono/epidemiologia
Traqueia/anormalidades
Doenças da Traqueia/congênito
[Mh] Termos MeSH secundário: Cartilagem/cirurgia
Criança
Pré-Escolar
Craniossinostoses/epidemiologia
Craniossinostoses/cirurgia
Feminino
Seres Humanos
Masculino
Morbidade/tendências
Estudos Retrospectivos
Apneia Obstrutiva do Sono/etiologia
Apneia Obstrutiva do Sono/cirurgia
Taxa de Sobrevida/tendências
Traqueia/cirurgia
Doenças da Traqueia/diagnóstico
Doenças da Traqueia/epidemiologia
Traqueostomia/métodos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003489


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[PMID]:29054228
[Au] Autor:Mehdiratta N; Archer M; Stewart M; Dennis B; Grogan E
[Ad] Endereço:Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: nmehdiratta@gmail.com.
[Ti] Título:Novel Airway and Ventilator Management of Tracheobronchial Disruption After Blunt Trauma.
[So] Source:Ann Thorac Surg;104(5):e359-e361, 2017 Nov.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Tracheobronchial injuries can be difficult to diagnose and manage, especially in the presence of polytrauma. A 50-year-old woman presented as a Level I trauma activation after being struck by a motor vehicle. Initial evaluation demonstrated intracranial hemorrhage and multiple chest injuries, including multilevel bilateral rib fractures, pneumomediastinum, and concern for tracheobronchial injury. After initial stabilization, bronchoscopy was performed and demonstrated an injury to the carina. We report a novel airway and ventilation strategy in the setting of concomitant tracheobronchial injury after severe blunt chest trauma in which extracorporeal support is contraindicated.
[Mh] Termos MeSH primário: Brônquios/lesões
Traumatismos Torácicos/diagnóstico
Traumatismos Torácicos/terapia
Traqueia/lesões
Ferimentos não Penetrantes/complicações
[Mh] Termos MeSH secundário: Acidentes de Trânsito
Broncoscopia/métodos
Terapia Combinada
Feminino
Seguimentos
Seres Humanos
Escala de Gravidade do Ferimento
Meia-Idade
Traumatismo Múltiplo/diagnóstico
Traumatismo Múltiplo/cirurgia
Respiração com Pressão Positiva/métodos
Radiografia Torácica/métodos
Medição de Risco
Traumatismos Torácicos/etiologia
Centros de Traumatologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171022
[St] Status:MEDLINE


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[PMID]:28984778
[Au] Autor:Xiang Z; Ai Z; Zhong G; Deng Y; Malhi H; Palmer S; Zee C
[Ad] Endereço:aDepartment of Radiology, Panyu Central Hospital of Guangzhou, Guangzhou, P.R. China bDepartment of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China cDepartment of Radiology, Keck Medical Center of USC, Los Angeles, CA.
[Ti] Título:Diagnostic value of using multiplanar reformation images: Case report for rare endotracheal hamartomas.
[So] Source:Medicine (Baltimore);96(40):e8231, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Pulmonary hamartomas are the most common benign tumor of the lung. Two types of pathologically similar hamartomas exist based on their location. These tumors have a low incidence, are rarely reported and frequently misdiagnosed because of lack of familiarity and/or understanding concerning their imaging features. PATIENT CONCERNS: Seventeen patients received treatment between June 2007 and May 2013 and had complete medical records. All of them had different degrees of cough and expectoration. Other symptoms include fever (5 cases), hemoptysis (4 cases), chest pain (3 cases), shortness of breath (2 cases), and dyspnea (1 case). DIAGNOSES: These patients all have pathologically confirmed, and informed the diagnosis of endobronchial hamartoma. INTERVENTIONS: Unenhanced and enhanced CT scans were performed using Toshiba Aquilion 64-slice and GE Lightspeed 64-slice CT scanners. The scan was performed from the superior thoracic aperture to the lateral costophrenic angle. The transaxial CT data was inserted into a Volume Wizard workstation to reconstruct images using MPR technique. OUTCOMES: The relationship between the location of the tumor and bronchi was clearly displayed on the axial images in only 2 patients. In all 17 patients, reconstructed MPR images were able to display the tumor parallel to the long axis of bronchi, thus facilitating in tumor identification and positioning along the bronchial tree. LESSONS: MPR images are valuable tools in the diagnosis of endobronchial hamartomas. Chiefly, these reconstructions aid in the detection of intratumoral fat/calcification and clearly demonstrate the tumors relationship and effect with the adjacent bronchi.
[Mh] Termos MeSH primário: Broncopatias/diagnóstico por imagem
Hamartoma/diagnóstico por imagem
Processamento de Imagem Assistida por Computador/métodos
Tomografia Computadorizada por Raios X/métodos
Doenças da Traqueia/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Brônquios/diagnóstico por imagem
Broncopatias/complicações
Dor no Peito/diagnóstico por imagem
Dor no Peito/etiologia
Tosse/diagnóstico por imagem
Tosse/etiologia
Dispneia/diagnóstico por imagem
Dispneia/etiologia
Feminino
Hamartoma/complicações
Hemoptise/diagnóstico por imagem
Hemoptise/etiologia
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Traqueia/diagnóstico por imagem
Doenças da Traqueia/complicações
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008231


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[PMID]:28930836
[Au] Autor:Zhang H; Wang S; Lu Z; Zhu L; Du X; Wang H; Xu Z
[Ad] Endereço:Department of Pediatric Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
[Ti] Título:Slide tracheoplasty in 81 children: Improved outcomes with modified surgical technique and optimal surgical age.
[So] Source:Medicine (Baltimore);96(38):e8013, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the surgical outcome of slide tracheoplasty.Eighty-one patients who underwent slide tracheoplasty were retrospectively reviewed. Before and after operation, all patients were examined by computed tomography (CT) and bronchoscopy regularly.There were 8 deaths and the mortality was 9.9%. They all died of respiratory failure associated with the formation of granulation tissue in the airway postoperatively. The mortality was 15.8% from 2009 to 2012 and decreased to 8.1% from 2013 to 2016. The mortality of patients aged 10 to 24 months was 5.7%, which was significantly lower than those younger than 10 months and those older than 24 months. After surgery, 11 patients had granulation tissue growing at anastomosis edges and 8 of them died eventually. Twenty patients had mucosa varus at the site of anastomosis which mainly happened in the early time. Between different time periods and different age groups, there was significant difference in the incidence of granulation tissue and mucosa varus (P < .01). Clinical symptoms of tracheal stenosis disappeared and the results of CT were satisfactory after operation.Slide tracheoplasty is an effective surgical method for congenital tracheal stenosis associated with congenital heart disease. With the continuous improvement of surgical technique, the mortality has been reduced and the incidence of granulation tissue and mucosa varus also has been reduced. The period of 10 to 24 months of age is the optimal cure time.
[Mh] Termos MeSH primário: Traqueia/cirurgia
Estenose Traqueal/cirurgia
[Mh] Termos MeSH secundário: Fatores Etários
Broncoscopia
Pré-Escolar
Feminino
Tecido de Granulação/patologia
Cardiopatias Congênitas/complicações
Seres Humanos
Lactente
Masculino
Complicações Pós-Operatórias/mortalidade
Complicações Pós-Operatórias/patologia
Insuficiência Respiratória/etiologia
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
Traqueia/diagnóstico por imagem
Estenose Traqueal/complicações
Estenose Traqueal/congênito
Estenose Traqueal/diagnóstico por imagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008013


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Montassier, Hélio José
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[PMID]:28895517
[Au] Autor:Santos Fernando F; Coelho Kasmanas T; Diniz Lopes P; da Silva Montassier MF; Zanella Mores MA; Casagrande Mariguela V; Pavani C; Moreira Dos Santos R; Assayag MS; Montassier HJ
[Ad] Endereço:1​Department of Veterinary Pathology, Laboratory of Virology and Immunology, Universidade Estadual Paulista Júlio de Mesquita Filho (FCAV- UNESP), Jaboticabal, SP 14884-900, Brazil.
[Ti] Título:Assessment of molecular and genetic evolution, antigenicity and virulence properties during the persistence of the infectious bronchitis virus in broiler breeders.
[So] Source:J Gen Virol;98(10):2470-2481, 2017 Oct.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The infectious bronchitis virus (IBV) causes a highly contagious disease [infectious bronchitis (IB)] that results in substantial economic losses to the poultry industry worldwide. We conducted a molecular and phylogenetic analysis of the S1 gene of Brazilian (BR) IBV isolates from a routinely vaccinated commercial flock of broiler breeders, obtained from clinical IB episodes that occurred in 24-, 46- and 62-week-old chickens. We also characterized the antigenicity, pathogenesis, tissue tropism and spreading of three IBV isolates by experimental infection of specific pathogen-free (SPF) chickens and contact sentinel birds. The results reveal that the three IBV isolates mainly exhibited mutations in the hypervariable regions (HVRs) of the S1 gene and protein, but were phylogenetically and serologically closely related, belonging to lineage 11 of the GI genotype, the former BR genotype I. All three isolates caused persistent infection in broiler breeders reared in the field, despite high systemic anti-IBV antibody titres, and exhibited tropism and pathogenicity for the trachea and kidney after experimental infection in SPF chickens and contact birds. In conclusion, BR genotype I isolates of IBV evolve continuously during the productive cycle of persistently infected broiler breeders, causing outbreaks that are not impaired by the current vaccination programme with Massachusetts vaccine strains. In addition, the genetic alterations in the S1 gene of these isolates were not able to change their tissue tropism and pathogenicity, but did seem to negatively influence the effectiveness of the host immune responses against these viruses, and favour viral persistence.
[Mh] Termos MeSH primário: Proteínas do Capsídeo/genética
Galinhas/virologia
Infecções por Coronavirus/veterinária
Vírus da Bronquite Infecciosa/genética
Vírus da Bronquite Infecciosa/imunologia
Doenças das Aves Domésticas/virologia
[Mh] Termos MeSH secundário: Animais
Brasil
Infecções por Coronavirus/imunologia
Infecções por Coronavirus/virologia
Vírus da Bronquite Infecciosa/isolamento & purificação
Vírus da Bronquite Infecciosa/patogenicidade
Rim/virologia
Traqueia/virologia
Tropismo Viral/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000893


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[PMID]:28833230
[Au] Autor:Schwartz T; Faria J; Pawar S; Siegel D; Chun RH
[Ad] Endereço:Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.
[Ti] Título:Efficacy and rebound rates in propranolol-treated subglottic hemangioma: A literature review.
[So] Source:Laryngoscope;127(11):2665-2672, 2017 Nov.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Propranolol has recently become the treatment of choice for management of subglottic and airway hemangiomas. This literature review aimed to determine the success rate of propranolol for managing these lesions as well as the rate of rebound growth following propranolol treatment cessation. STUDY DESIGN: Literature search involving MEDLINE and Scopus to identify English-language articles. METHODS: Studies were identified using hemangioma, subglottic or airway, and propranolol for search terms. Studies were eligible for inclusion if they reported the treatment used, individual deidentified patient data, and contained patients without medical or surgical treatment prior to propranolol therapy RESULTS: Initial review included 107 abstracts. Twenty-four articles including case reports and case series met inclusion criteria and were included in the qualitative analysis. Forty-nine patients were included. Twenty-eight (57%) were treated with propranolol alone, and 20 (41%) were treated with a combination of propranolol and a corticosteroid. Thirty-seven (76%) of patients were treated with a dose of 2 mg/kg/d of propranolol. The initial treatment was successful in 43 (88%) of patients. Rebound growth occurred in four (9%) patients. Overall, six (12%) patients underwent surgical resection. CONCLUSIONS: Propranolol is efficacious for treating subglottic hemangiomas. Rebound growth does occur in a small subset of patients during the propranolol wean. Close observation for children during weaning of propranolol therapy for subglottic hemangioma is essential. Adjunctive management strategies need to be used in patients with rebound growth. Laryngoscope, 127:2665-2672, 2017.
[Mh] Termos MeSH primário: Hemangioma/tratamento farmacológico
Propranolol/uso terapêutico
Doenças da Traqueia/tratamento farmacológico
Vasodilatadores/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Vasodilator Agents); 9Y8NXQ24VQ (Propranolol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26818


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[PMID]:28767607
[Au] Autor:Li M; Zhu W; Khan RSU; Saeed U; Shi S; Luo Z
[Ad] Endereço:aDepartment of Respiratory Medicine bDepartment of Pharmacy, First Affiliated Hospital of Kunming Medical University cPostgraduate School of Kunming Medical University, Kunming, Yunnan, P.R. China.
[Ti] Título:Primary clear cell carcinoma of the trachea: A CARE-compliant case report.
[So] Source:Medicine (Baltimore);96(31):e7709, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Primary clear cell carcinoma of the lung is a rare condition, and presentation as an endotracheal lesion is even more unusual. In this report, we present a patient with clear cell carcinoma occurring in the trachea, which obstructed the tracheal lumen and lead to the respiratory distress. PATIENT CONCERNS: A 60-year old female patient was admitted due to a 6-month history of dyspnea with worsening symptoms for 1 month. Chest CT scan revealed a smooth nodular shadow with homogeneous density on the wall of upper trachea. DIAGNOSIS: Bronchoscopy therapy and surgical removal of the tumor were performed. The histopathological diagnosis revealed clear cell carcinoma. INTERVENTION: Surgical removal of the clear cell carcinoma was performed. OUTCOMES: The patient recovered well after the surgery and is now being followed-up after hospital discharge. LESSONS: Bronchoscopy is an essential tool for diagnosis of tracheal clear cell carcinoma. Surgical removal should be performed if possible.
[Mh] Termos MeSH primário: Adenocarcinoma de Células Claras/diagnóstico
Adenocarcinoma de Células Claras/cirurgia
Neoplasias da Traqueia/diagnóstico
Neoplasias da Traqueia/cirurgia
[Mh] Termos MeSH secundário: Adenocarcinoma de Células Claras/complicações
Adenocarcinoma de Células Claras/patologia
Diagnóstico Diferencial
Dispneia/diagnóstico
Dispneia/etiologia
Dispneia/patologia
Dispneia/cirurgia
Feminino
Seres Humanos
Meia-Idade
Traqueia/diagnóstico por imagem
Traqueia/patologia
Traqueia/cirurgia
Neoplasias da Traqueia/complicações
Neoplasias da Traqueia/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007709


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[PMID]:28763472
[Au] Autor:Amarasinghe A; Abdul-Cader MS; Nazir S; De Silva Senapathi U; van der Meer F; Cork SC; Gomis S; Abdul-Careem MF
[Ad] Endereço:Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Health Research Innovation Center 2C53, Calgary, Alberta, Canada.
[Ti] Título:Infectious bronchitis corona virus establishes productive infection in avian macrophages interfering with selected antimicrobial functions.
[So] Source:PLoS One;12(8):e0181801, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Infectious bronchitis virus (IBV) causes respiratory disease leading to loss of egg and meat production in chickens. Although it is known that macrophage numbers are elevated in the respiratory tract of IBV infected chickens, the role played by macrophages in IBV infection, particularly as a target cell for viral replication, is unknown. In this study, first, we investigated the ability of IBV to establish productive replication in macrophages in lungs and trachea in vivo and in macrophage cell cultures in vitro using two pathogenic IBV strains. Using a double immunofluorescent technique, we observed that both IBV Massachusetts-type 41 (M41) and Connecticut A5968 (Conn A5968) strains replicate in avian macrophages at a low level in vivo. This in vivo observation was substantiated by demonstrating IBV antigens in macrophages following in vitro IBV infection. Further, IBV productive infection in macrophages was confirmed by demonstrating corona viral particles in macrophages and IBV ribonucleic acid (RNA) in culture supernatants. Evaluation of the functions of macrophages following infection of macrophages with IBV M41 and Conn A5968 strains revealed that the production of antimicrobial molecule, nitric oxide (NO) is inhibited. It was also noted that replication of IBV M41 and Conn A5968 strains in macrophages does not interfere with the induction of type 1 IFN activity by macrophages. In conclusion, both M41 and Con A5968 IBV strains infect macrophages in vivo and in vitro resulting productive replications. During the replication of IBV in macrophages, their ability to produce NO can be affected without affecting the ability to induce type 1 IFN activity. Further studies are warranted to uncover the significance of macrophage infection of IBV in the pathogenesis of IBV infection in chickens.
[Mh] Termos MeSH primário: Infecções por Coronavirus/imunologia
Vírus da Bronquite Infecciosa
Macrófagos/virologia
Doenças das Aves Domésticas/virologia
[Mh] Termos MeSH secundário: Animais
Galinhas
Genoma Viral
Pulmão/patologia
Macrófagos/imunologia
Microscopia de Fluorescência
Óxido Nítrico/química
Doenças das Aves Domésticas/imunologia
Traqueia/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181801



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