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[PMID]:29499674
[Au] Autor:Casas P; Ascaso FJ; Vicente E; Tejero-Garcés G; Adiego MI; Cristóbal JA
[Ad] Endereço:Department of Ophthalmology, Hospital Clínico Universitario "Lozano Blesa", San Juan Bosco 15, ES-50009, Zaragoza, Spain. paulacasaspascual@hotmail.com.
[Ti] Título:Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls.
[So] Source:BMC Ophthalmol;18(1):66, 2018 Mar 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To assess the retinal sensitivity in obstructive sleep apnea hypopnea syndrome (OSAHS) patients evaluated with standard automated perimetry (SAP). And to correlate the functional SAP results with structural parameters obtained with optical coherence tomography (OCT). METHODS: This prospective, observational, case-control study consisted of 63 eyes of 63 OSAHS patients (mean age 51.7 ± 12.7 years, best corrected visual acuity ≥20/25, refractive error less than three spherical or two cylindrical diopters, and intraocular pressure < 21 mmHg) who were enrolled and compared with 38 eyes of 38 age-matched controls. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Stratus OCT and SAP sensitivities and indices were explored with Humphrey Field Analyzer perimeter. Correlations between functional and structural parameters were calculated, as well as the relationship between ophthalmologic and systemic indices in OSAHS patients. RESULTS: OSAHS patients showed a significant reduction of the sensitivity for superior visual field division (p = 0.034, t-student test). When dividing the OSAHS group in accordance with the severity of the disease, nasal peripapillary RNFL thickness was significantly lower in severe OSAHS than that in controls and mild-moderate cases (p = 0.031 and p = 0.016 respectively, Mann-Whitney U test). There were no differences between groups for SAP parameters. We found no correlation between structural and functional variables. The central visual field sensitivity of the SAP revealed a poor Pearson correlation with the apnea-hipopnea index (0.284, p = 0.024). CONCLUSIONS: Retinal sensitivity show minor differences between healthy subjects and OSAHS. Functional deterioration in OSAHS patients is not easy to demonstrate with visual field examination.
[Mh] Termos MeSH primário: Fibras Nervosas/patologia
Doenças do Nervo Óptico/etiologia
Células Ganglionares da Retina/patologia
Apneia Obstrutiva do Sono/complicações
Transtornos da Visão/etiologia
Campos Visuais
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Doenças do Nervo Óptico/diagnóstico
Estudos Prospectivos
Apneia Obstrutiva do Sono/diagnóstico
Tomografia de Coerência Óptica
Transtornos da Visão/diagnóstico
Testes de Campo Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180304
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0728-z


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[PMID]:29390337
[Au] Autor:González Saldaña N; Galvis Trujillo DM; Borbolla Pertierra AM; Mondragón Pineda AI; Juárez Olguín H
[Ad] Endereço:Department of Infectology, National Institute of Pediatrics.
[Ti] Título:Linezolid-associated optic neuropathy in a pediatric patient with Mycobacterium nonchromogenicum: A case report.
[So] Source:Medicine (Baltimore);96(50):e9200, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Toxic optic neuropathies are alterations of the optic nerve and can be caused by environmental, pharmacological, or nutritional agents. CASE: It is about a 7-year-old male patient, a native of the State of Mexico, Mexico who was diagnosed with cervical mycobacterial lymphadenitis that required management with linezolid. OBSERVATIONS: After 7 months of treatment, visual acuity of the left eye decreased and was accompanied by headache. Neuroinfection and other central nervous system affections were discarded. An adverse effect related to treatment with linezolid was suspected, and linezolid was suspended. The symptoms subsided after discontinuation; however, the patient continued to show decreased visual acuity of the left eye, assessed by his ability to count 2 fingers. The right eye remained unaffected. CONCLUSIONS: Neurotoxicity can be decreased by reducing the total dose of linezolid or by administrating it in an intermittent form. To avoid progression and loss of vision, we suggest frequent periodic ophthalmological evaluation in patients treated with linezolid.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Linezolida/efeitos adversos
Linfadenite/tratamento farmacológico
Linfadenite/microbiologia
Infecções por Micobactéria não Tuberculosa/tratamento farmacológico
Infecções por Micobactéria não Tuberculosa/microbiologia
Doenças do Nervo Óptico/induzido quimicamente
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Masculino
Micobactérias não Tuberculosas
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); ISQ9I6J12J (Linezolid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009200


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[PMID]:29298687
[Au] Autor:Aojula A; Mollan SP; Horsburgh J; Yiangou A; Markey KA; Mitchell JL; Scotton WJ; Keane PA; Sinclair AJ
[Ad] Endereço:Institute of Metabolism and Systems Research, University of Birmingham, B15 2TT, Birmingham, UK.
[Ti] Título:Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension.
[So] Source:BMC Ophthalmol;17(1):257, 2018 Jan 04.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls. METHODS: Baseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and controls with no retinal or optic nerve pathology, were examined. The internal limiting membrane and RNFL thickness of the most severely affected eye was examined for SegE and re-segmented. Using ImageJ, the total area of the RNFL thickness was calculated pre and post re-segmentation and the percentage change was determined. The distribution of RNFL thickness error was qualitatively assessed. RESULTS: Significantly greater SegE (p = 0.009) was present in RNFL thickness total area, assessed using ImageJ, in IIH patients (n = 46, 5% ± 0-58%) compared to controls (n = 14, 1% ± 0-6%). This was particularly evident in moderate to severe optic disc swelling (n = 23, 10% ± 0-58%, p < 0.001). RNFL thickness was unable to be quantified using SDOCT in patients with severe papilloedema. CONCLUSIONS: SegE remain a concern for clinicians using SDOCT to monitor papilloedema in IIH, particularly in the assessment of eyes with moderate to severe oedema. Systematic assessment and manual refinement of SegE is therefore important to ensure the accuracy in longitudinal monitoring of patients.
[Mh] Termos MeSH primário: Fibras Nervosas/patologia
Disco Óptico/patologia
Papiledema/diagnóstico
Pseudotumor Cerebral/diagnóstico
Células Ganglionares da Retina/patologia
Tomografia de Coerência Óptica/métodos
Campos Visuais
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Papiledema/etiologia
Papiledema/fisiopatologia
Pseudotumor Cerebral/complicações
Pseudotumor Cerebral/fisiopatologia
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0652-7


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[PMID]:29397523
[Au] Autor:Robson AG; Nilsson J; Li S; Jalali S; Fulton AB; Tormene AP; Holder GE; Brodie SE
[Ad] Endereço:Department of Electrophysiology, Moorfields Eye Hospital, 162 City Road, London, UK. anthony.robson@moorfields.nhs.uk.
[Ti] Título:ISCEV guide to visual electrodiagnostic procedures.
[So] Source:Doc Ophthalmol;136(1):1-26, 2018 02.
[Is] ISSN:1573-2622
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Clinical electrophysiological testing of the visual system incorporates a range of noninvasive tests and provides an objective indication of function relating to different locations and cell types within the visual system. This document developed by the International Society for Clinical Electrophysiology of Vision provides an introduction to standard visual electrodiagnostic procedures in widespread use including the full-field electroretinogram (ERG), the pattern electroretinogram (pattern ERG or PERG), the multifocal electroretinogram (multifocal ERG or mfERG), the electrooculogram (EOG) and the cortical-derived visual evoked potential (VEP). The guideline outlines the basic principles of testing. Common clinical presentations and symptoms are described with illustrative examples and suggested investigation strategies.
[Mh] Termos MeSH primário: Eletrodiagnóstico/normas
Eletroculografia
Eletrofisiologia/organização & administração
Eletrorretinografia/métodos
Potenciais Evocados Visuais
Guias de Prática Clínica como Assunto
[Mh] Termos MeSH secundário: Seres Humanos
Agências Internacionais
Doenças do Nervo Óptico/diagnóstico
Doenças Retinianas/diagnóstico
Sociedades Médicas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180205
[St] Status:MEDLINE
[do] DOI:10.1007/s10633-017-9621-y


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[PMID]:29381959
[Au] Autor:Wu PC; Tien PT; Li YH; Chen RY; Cho DY
[Ad] Endereço:Division of Rheumatology and Immunology, Department of Internal Medicine, China Medical University Hospital.
[Ti] Título:IgG4-related cerebral pseudotumor with perineural spreading along branches of the trigeminal nerves causing compressive optic neuropathy: A case report.
[So] Source:Medicine (Baltimore);96(47):e8709, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Immunoglobulin G4-related disease (IgG4-RD) is characterized by tumor-like lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis. IgG4-RD has been described in a variety of organ systems; however, it rarely involves the central nervous system. PATIENT CONCERNS: A 17-year-old woman visited our clinic with a complaint of blurred vision for the past 5 months. She also reported a painless right submandibular mass that had been present for 1 year. Her best-corrected visual acuity (BCVA) was 2.0 LogMAR, with an almost total visual field defect in the right eye. DIAGNOSES: Magnetic resonance imaging (MRI) revealed lobulated parasellar tumors with perineural spreading along branches of the trigeminal nerves causing right optic nerve compression. A craniotomy with tumor removal and submandibular gland biopsy was performed. Histopathological analysis of the tumor revealed stromal fibrosis with atypical lymphoid infiltrations. Histopathological and immunohistochemical analysis of the submandibular gland confirmed the diagnosis of IgG4-RD. INTERVENTIONS: The patient was administered 500mg/d of pulse methylprednisolone for 3 days, 500mg of intravenous rituximab every 2 weeks (for a total of 2 doses), and 500mg of intravenous pulse cyclophosphamide every month (for a total of 3 doses). OUTCOMES: Two months after the initiation of immunosuppressive therapy, the patient's BCVA returned to 0.1 LogMAR with visual field defect recovery. The follow-up MRI showed the almost complete disappearance of the previously contrast-enhanced lesions. LESSONS: Herein, we report a rare case of IgG4-RD presenting as a parasellar tumor and present a review of the related literature. Based on the case report, we propose that aggressive therapy with glucocorticoid, rituximab, and cyclophosphamide may potentially be useful for treating such cases.
[Mh] Termos MeSH primário: Imunoglobulina G/imunologia
Doenças do Nervo Óptico/imunologia
Pseudotumor Cerebral/imunologia
Nervo Trigêmeo/patologia
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Metilprednisolona/uso terapêutico
Doenças do Nervo Óptico/tratamento farmacológico
Doenças do Nervo Óptico/cirurgia
Pseudotumor Cerebral/tratamento farmacológico
Pseudotumor Cerebral/cirurgia
Rituximab/uso terapêutico
Glândula Submandibular/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 4F4X42SYQ6 (Rituximab); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008709


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[PMID]:29420144
[Au] Autor:Gilbert AL; Chwalisz B; Mallery R
[Ad] Endereço:a Department of Neuro-Ophthalmology , Massachusetts Eye & Ear, Harvard Medical School , Boston , MA , USA.
[Ti] Título:Complications of Optic Nerve Sheath Fenestration as a Treatment for Idiopathic Intracranial Hypertension.
[So] Source:Semin Ophthalmol;33(1):36-41, 2018.
[Is] ISSN:1744-5205
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There are a number of surgical options for treatment of idiopathic intracranial hypertension (IIH) when it is refractory to medical treatment and weight loss. Optic nerve sheath fenestration (ONSF) is one of these options. Use of this procedure varies among centers due to experience with the procedure and concern for associated complications that can result in severe loss of vision. This review summarizes the literature concerning post-surgical complications of ONSF for IIH.
[Mh] Termos MeSH primário: Cegueira
Descompressão Cirúrgica/efeitos adversos
Procedimentos Neurocirúrgicos/efeitos adversos
Traumatismos do Nervo Óptico/etiologia
Nervo Óptico/cirurgia
Papiledema/cirurgia
Pseudotumor Cerebral/complicações
[Mh] Termos MeSH secundário: Cegueira/epidemiologia
Cegueira/etiologia
Cegueira/fisiopatologia
Seres Humanos
Nervo Óptico/patologia
Traumatismos do Nervo Óptico/diagnóstico
Traumatismos do Nervo Óptico/fisiopatologia
Papiledema/diagnóstico
Papiledema/etiologia
Complicações Pós-Operatórias
Pseudotumor Cerebral/fisiopatologia
Pseudotumor Cerebral/cirurgia
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1080/08820538.2017.1353810


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[PMID]:29402238
[Au] Autor:Tanyildiz B; Tezcan ME; Kandemir B; Günaydin NT; Göktas E; Tangilntiz A; Arsan AK
[Ad] Endereço:Dr. Lutfi Kirdar Kartal Education and Research Hospital, Department of Ophthalmology, Semsi Denizer Caddesi, E-5, 34890, Kartal Istanbul, Turkey. buraktanyildiz@yahoo.com.
[Ti] Título:Effect of oral Colchicine on Peripapillary retinal nerve fiber layer thickness in patients with familial Mediterranean fever.
[So] Source:BMC Ophthalmol;18(1):27, 2018 Feb 05.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The purpose of this study is to investigate whether oral colchicine has an effect on peripapillary retinal nerve fiber layer (pRNFL) thickness of familial Mediterranean fever (FMF) patients. METHODS: We conducted a cross sectional study by comparing pRNFL thickness of FMF patients on colchicine (treated group), newly diagnosed colchicine naïve FMF patients (untreated group) and healthy controls. The study included 66 FMF patients and 32 healthy control subjects. Treated FMF patients were grouped according to colchicine use, duration of use and dosage. pRNFL thickness of the patients and controls were measured by using optical coherence tomography and the measurements were compared. RESULTS: No statistically significant difference was found between the pRNFL thickness in untreated group, treated group and the healthy control group (all p > 0.05). No statistically significant difference was found between pRNFL thickness in the healthy control group and FMF patients grouped according to duration or dosage of colchicine use (all p > 0.05). CONCLUSIONS: According to our study, FMF and oral colchicine use had no statistically significant effect on pRNFL thickness.
[Mh] Termos MeSH primário: Colchicina/uso terapêutico
Febre Familiar do Mediterrâneo/tratamento farmacológico
Fibras Nervosas/efeitos dos fármacos
Células Ganglionares da Retina/efeitos dos fármacos
Moduladores de Tubulina/uso terapêutico
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Estudos Transversais
Feminino
Seres Humanos
Pressão Intraocular
Masculino
Meia-Idade
Fibras Nervosas/patologia
Disco Óptico
Células Ganglionares da Retina/patologia
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tubulin Modulators); SML2Y3J35T (Colchicine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0698-1


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[PMID]:29394916
[Au] Autor:Chen Y; Ma X; Hua R
[Ad] Endereço:Department of Ophthalmology, First Hospital of China Medical University, No. 155 Nanjingbei Street, Heping District, Shenyang, Liaoning Province, People's Republic of China.
[Ti] Título:Multi-modality imaging findings of huge intrachoroidal cavitation and myopic peripapillary sinkhole.
[So] Source:BMC Ophthalmol;18(1):24, 2018 Feb 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Peripapillary intrachoroidal cavitation was described as the presence of an asymptomatic, well-circumscribed, yellow-orange, peripapillary lesion at the inferior border of the myopic conus in eyes with high myopia. CASE PRESENTATION: A 66-year-old myopic Chinese man was enrolled and his multi-color imaging examination showed a well-circumscribed, caesious, peripapillary lesion coalesced with the optic nerve head vertically rotated and obliquely tilted, together with an inferotemporal sinkhole in the myopic conus. The optical coherence tomography images showed an intrachoroidal hyporeflective space, schisis, an intracavitary septum located below the retinal pigment epithelium and inserted beneath the optic nerve head, as well as a sinkhole between the peripapillary intrachoroidal cavitation and the vitreous space. CONCLUSIONS: Both myopic colobomas and sinkhole in myopic conus may contribute the coalescence of intrachoroidal cavitation with optic nerve head. These qualitative and quantitative new findings will be beneficial for understanding its pathomorphological mechanism, and the impact on optic nerve tissue of myopic patients.
[Mh] Termos MeSH primário: Doenças da Coroide/diagnóstico por imagem
Anormalidades do Olho/diagnóstico por imagem
Miopia/diagnóstico por imagem
Disco Óptico/anormalidades
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Masculino
Imagem Multimodal
Campos Visuais
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0681-x


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[PMID]:29242987
[Au] Autor:Baneke AJ; Williams KM; Mahroo OA; Mohamed M; Hammond CJ
[Ad] Endereço:Department of Ophthalmology, King's College London, St Thomas' Hospital Campus, Westminster Bridge Road, London, SE1 7EH, UK. alexbaneke@yahoo.co.uk.
[Ti] Título:A twin study of cilioretinal arteries, tilted discs and situs inversus.
[So] Source:Graefes Arch Clin Exp Ophthalmol;256(2):333-340, 2018 Feb.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To establish the prevalence and heritability of cilioretinal arteries (CRAs), tilted discs (TDs) and situs inversus (SI). METHODS: Fundus photos from the Twins UK Adult Twin registry twin database were analyzed: 1812 individuals, 526 complete monozygotic (MZ) twin pairs and 336 complete dizygotic (DZ) pairs. Images were assessed non-stereoscopically on a computer screen by the same ophthalmologist for presence of CRAs, TDs or SI. Prevalence figures, probandwise concordances and heritabilities were calculated. RESULTS: Prevalence of a CRA in subjects' right eyes was 28.6% (26.5-30.8). Prevalence of subjects with a CRA in at least one eye was 45.0% (42.6-47.5), with a TD in at least one eye was 1.2% (0.8-1.9), and with SI at least one eye was 0.5% (0.3-1.0). There was no association between birth weight and presence of CRA. Concordance for CRA in at least one eye (MZ twins) was 60% (95% CI 55-64), and (DZ) was 45% (95% CI 39-51). Heritability for CRAs in at least one eye was 49.4% (95% CI 38.1-59.7) and for both eyes was 32.9% (95% CI 10.4-53.3). We were unable to calculate meaningful heritabilities or concordances for TDs and situs SI, due to insufficient numbers. CONCLUSIONS: The presence of CRAs appears to be moderately heritable, with greater variance explained by individual environmental factors or even stochastic events. They were not associated with low birth weight. Future genetic research and studies of birth/lifecourse cohorts may offer further insights into the etiology of congenital papillovascular abnormalities.
[Mh] Termos MeSH primário: Anormalidades Múltiplas
Artérias Ciliares/patologia
Doenças em Gêmeos/genética
Disco Óptico/anormalidades
Doenças do Nervo Óptico/genética
Artéria Retiniana/patologia
Situs Inversus/genética
[Mh] Termos MeSH secundário: Doenças em Gêmeos/diagnóstico
Feminino
Predisposição Genética para Doença
Seres Humanos
Masculino
Meia-Idade
Doenças do Nervo Óptico/diagnóstico
Sistema de Registros
Situs Inversus/diagnóstico
Gêmeos Monozigóticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; TWIN STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3859-7


  10 / 13507 MEDLINE  
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[PMID]:29238852
[Au] Autor:Maertz J; Kolb JP; Klein T; Mohler KJ; Eibl M; Wieser W; Huber R; Priglinger S; Wolf A
[Ad] Endereço:Augenklinik der Ludwig-Maximilians-Universität München, Campus Innenstadt, Mathildenstraße 8, D-80336, Munich, Germany.
[Ti] Título:Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm.
[So] Source:Graefes Arch Clin Exp Ophthalmol;256(2):289-298, 2018 Feb.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To demonstrate papillary imaging of eyes with optic disc pits (ODP) or optic disc pit associated maculopathy (ODP-M) with ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s. To generate 3D-renderings of the papillary area with 3D volume-reconstructions of the ODP and highly resolved en face images from a single densely-sampled megahertz-OCT (MHz-OCT) dataset for investigation of ODP-characteristics. METHODS: A 1.68 MHz-prototype SS-MHz-OCT system at 1050 nm based on a Fourier-domain mode-locked laser was employed to acquire high-definition, 3D datasets with a dense sampling of 1600 × 1600 A-scans over a 45° field of view. Six eyes with ODPs, and two further eyes with glaucomatous alteration or without ocular pathology are presented. 3D-rendering of the deep papillary structures, virtual 3D-reconstructions of the ODPs and depth resolved isotropic en face images were generated using semiautomatic segmentation. RESULTS: 3D-rendering and en face imaging of the optic disc, ODPs and ODP associated pathologies showed a broad spectrum regarding ODP characteristics. Between individuals the shape of the ODP and the appending pathologies varied considerably. MHz-OCT en face imaging generates distinct top-view images of ODPs and ODP-M. MHz-OCT generates high resolution images of retinal pathologies associated with ODP-M and allows visualizing ODPs with depths of up to 2.7 mm. CONCLUSIONS: Different patterns of ODPs can be visualized in patients for the first time using 3D-reconstructions and co-registered high-definition en face images extracted from a single densely sampled 1050 nm megahertz-OCT (MHz-OCT) dataset. As the immediate vicinity to the SAS and the site of intrapapillary proliferation is located at the bottom of the ODP it is crucial to image the complete structure and the whole depth of ODPs. Especially in very deep pits, where non-swept-source OCT fails to reach the bottom, conventional swept-source devices and the MHz-OCT alike are feasible and beneficial methods to examine deep details of optic disc pathologies, while the MHz-OCT bears the advantage of an essentially swifter imaging process.
[Mh] Termos MeSH primário: Anormalidades do Olho/diagnóstico
Imagem Tridimensional
Macula Lutea/patologia
Disco Óptico/patologia
Doenças Retinianas/diagnóstico
Tomografia de Coerência Óptica/instrumentação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Desenho de Equipamento
Feminino
Seres Humanos
Masculino
Meia-Idade
Disco Óptico/anormalidades
Projetos Piloto
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3857-9



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