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[PMID]:28459655
[Au] Autor:Kysil EV; Meshalkina DA; Frick EE; Echevarria DJ; Rosemberg DB; Maximino C; Lima MG; Abreu MS; Giacomini AC; Barcellos LJG; Song C; Kalueff AV
[Ad] Endereço:1 Institute of Translational Biomedicine, St. Petersburg State University , St. Petersburg, Russia .
[Ti] Título:Comparative Analyses of Zebrafish Anxiety-Like Behavior Using Conflict-Based Novelty Tests.
[So] Source:Zebrafish;14(3):197-208, 2017 Jun.
[Is] ISSN:1557-8542
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Modeling of stress and anxiety in adult zebrafish (Danio rerio) is increasingly utilized in neuroscience research and central nervous system (CNS) drug discovery. Representing the most commonly used zebrafish anxiety models, the novel tank test (NTT) focuses on zebrafish diving in response to potentially threatening stimuli, whereas the light-dark test (LDT) is based on fish scototaxis (innate preference for dark vs. bright areas). Here, we systematically evaluate the utility of these two tests, combining meta-analyses of published literature with comparative in vivo behavioral and whole-body endocrine (cortisol) testing. Overall, the NTT and LDT behaviors demonstrate a generally good cross-test correlation in vivo, whereas meta-analyses of published literature show that both tests have similar sensitivity to zebrafish anxiety-like states. Finally, NTT evokes higher levels of cortisol, likely representing a more stressful procedure than LDT. Collectively, our study reappraises NTT and LDT for studying anxiety-like states in zebrafish, and emphasizes their developing utility for neurobehavioral research. These findings can help optimize drug screening procedures by choosing more appropriate models for testing anxiolytic or anxiogenic drugs.
[Mh] Termos MeSH primário: Ansiedade/psicologia
Conflito (Psicologia)
Atividade Motora/fisiologia
Peixe-Zebra/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Escuridão
Modelos Animais de Doenças
Hidrocortisona/análise
Luz
Estresse Psicológico
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE
[do] DOI:10.1089/zeb.2016.1415


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[PMID]:28393774
[Au] Autor:Kiran U; Ladha S; Makhija N; Kapoor PM; Choudhury M; Das S; Gharde P; Malik V; Airan B
[Ad] Endereço:Department of Cardiac Anaesthesia and Surgery, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, India.
[Ti] Título:The role of Rajyoga meditation for modulation of anxiety and serum cortisol in patients undergoing coronary artery bypass surgery: A prospective randomized control study.
[So] Source:Ann Card Anaesth;20(2):158-162, 2017 Apr-Jun.
[Is] ISSN:0974-5181
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Rajyoga meditation is a form of mind body intervention that is promoted by the Brahma Kumaris World Spiritual University. This form of meditation can be easily performed without rituals or mantras and can be practiced anywhere at any time. The practice of Rajyoga meditation can have beneficial effects on modulating anxiety and cortisol level in patients undergoing major cardiac surgery. MATERIALS AND METHODS: A prospective randomized control study was carried out in a single tertiary care center. One hundred and fifty patients undergoing elective coronary artery bypass surgery were enrolled in the study. The patients were randomized in two groups namely, Group 1 (Rajyoga group) and Group 2 (Control Group). Anxiety was measured on a visual analog scale 1-10 before the start of Rajyoga training or patient counseling (T1), on the morning of the day of surgery (T2), on the 2nd postoperative day (T3), and on the 5th postoperative day (T4). The serum cortisol level was measured in the morning of the day of surgery (T1), on the 2nd postoperative day (T2) and on the 5th postoperative day (T3), respectively. RESULTS: In the study, it was seen that the anxiety level of the patients before the surgery (T1) and on the day of surgery (T2) were comparable between the two groups. However on the 2nd postoperative day (T3), the patients who underwent Rajyoga training had lower anxiety level in comparison to the control group (3.12 ± 1.45 vs. 6.12 ± 0.14, P < 0.05) and on the 5th postoperative day (T4) it was seen that Rajyoga practice had resulted in significant decline in anxiety level (0.69 ± 1.1 vs. 5.6 ± 1.38, P < 0.05). The serum cortisol level was also favorably modulated by the practice of Rajyoga meditation. CONCLUSION: Mindbody intervention is found to effective in reducing the anxiety of the patients and modulating the cortisol level in patients undergoing wellknown stressful surgery like coronary artery bypass surgery.
[Mh] Termos MeSH primário: Ansiedade/sangue
Ansiedade/terapia
Ponte de Artéria Coronária/psicologia
Hidrocortisona/sangue
Meditação/métodos
Meditação/psicologia
[Mh] Termos MeSH secundário: Ansiedade/psicologia
Feminino
Humanos
Masculino
Meia-Idade
Complicações Pós-Operatórias/prevenção & controle
Complicações Pós-Operatórias/psicologia
Período Pré-Operatório
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE
[do] DOI:10.4103/aca.ACA_32_17


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[PMID]:28329370
[Au] Autor:Morgan E; Schumm LP; McClintock M; Waite L; Lauderdale DS
[Ad] Endereço:Department of Public Health Sciences, University of Chicago, Chicago, IL.
[Ti] Título:Sleep Characteristics and Daytime Cortisol Levels in Older Adults.
[So] Source:Sleep;40(5), 2017 May 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Objective: Older adults frequently report sleep problems and are at increased risk of cardiometabolic disruption. Experimental sleep restriction of younger adults has suggested that cortisol may be on the pathway between sleep restriction and cardiometabolic disease. We investigated whether the natural variation in sleep among older adults is associated with daytime cortisol level. Methods: Salivary cortisol samples and actigraphy sleep data were collected from a random subsample of participants in the National Social Life, Health and Aging Project, a nationally representative probability sample of adults aged 62-90 (N = 672). Salivary cortisol was measured with 3 timed samples at the beginning, middle, and end of a 2-hr in-home interview. Sleep characteristics were derived from wrist actigraphy (fragmentation, wake after sleep onset [WASO], and duration) and from survey responses about usual sleep duration and sleep problems. For each individual, a single summary daytime cortisol level was estimated by fitting a marginal longitudinal model for the 3 time-stamped cortisol samples. The resulting estimates were then regressed on each sleep measure, adjusting for sociodemographics, health behaviors, and comorbidities. Results: From actigraphy, both higher fragmentation score (ß = 0.02; 95% confidence interval [CI] = 0.00 to 0.03) and longer WASO (ß = 0.27; 95% CI = 0.04 to 0.51) were significantly associated with higher daytime cortisol; sleep duration was not. Self-reported sleep duration and sleep problems were also not associated with cortisol. Conclusion: Actigraph measures of sleep disturbance are associated with higher daytime cortisol among older adults. However, cross-sectional data cannot distinguish causal direction or whether cortisol and sleep disruption have a common cause.
[Mh] Termos MeSH primário: Hidrocortisona/análise
Transtornos do Sono-Vigília/metabolismo
Sono/fisiologia
[Mh] Termos MeSH secundário: Actigrafia
Idoso
Idoso de 80 Anos ou mais
Envelhecimento
Estudos Transversais
Feminino
Humanos
Entrevistas como Assunto
Masculino
Meia-Idade
Saliva/química
Autorrelato
Transtornos do Sono-Vigília/etiologia
Transtornos do Sono-Vigília/fisiopatologia
Inquéritos e Questionários
Fatores de Tempo
Punho
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsx043


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[PMID]:28538307
[Au] Autor:Schimpchen J; Wagner M; Ferrauti A; Kellmann M; Pfeiffer M; Meyer T
[Ad] Endereço:1Institute of Sports and Preventive Medicine, Saarland University, Saarbrücken, Germany; 2Faculty of Sport Science, Ruhr University, Bochum, Germany; 3School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia; and 4Institute of Sports Science, Johannes-Gutenberg University, Mainz, Germany.
[Ti] Título:Can Cold Water Immersion Enhance Recovery in Elite Olympic Weightlifters? An Individualized Perspective.
[So] Source:J Strength Cond Res;31(6):1569-1576, 2017 06.
[Is] ISSN:1533-4287
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated whether cold water immersion (CWI) after intensive training sessions can enhance recovery in elite Olympic weightlifters, taking into account each athlete's individual response pattern. The entire German male Olympic weightlifting national team participated in the study (n = 7), ensuring collection of data from elite athletes only. Using a randomized cross-over design, the athletes went through 2 high-intensity training microcycles consisting of 5 training sessions that were either followed by a CWI or passive recovery. Barbell speed in a snatch pull movement, blood parameters, and subjective ratings of general fatigue and recovery were assessed throughout the study. Physical performance at 2 snatch pull intensities (85% one repetition maximum [1RM]: -0.15% vs. -0.22%, p = 0.94; 90% 1RM: -0.7% vs. +1.23%, p = 0.25) did not differ significantly (condition × time). Although questionnaires revealed a significant decline in the ratings of overall recovery (p < 0.001) and a significantly higher rating of overall stress (p = 0.03) over time, no significant differences between conditions (p = 0.14; p = 0.98) could be revealed. Similarly, neither of the analyzed blood parameters changed significantly between conditions over time (creatine kinase: p = 0.53; urea: p = 0.43; cortisol: p = 0.59; testosterone: p = 0.53; testosterone:cortisol ratio: p = 0.69). In general, CWI did not prove to be an effective tool to enhance recovery in elite Olympic weightlifters over a 3-day intensive training period. However, even though the group was rather homogeneous with regard to performance, there were considerable intersubject differences in their response to CWI. It seems that athletes are best advised on a case-by-case basis.
[Mh] Termos MeSH primário: Desempenho Atlético/fisiologia
Temperatura Baixa
Fadiga/terapia
Hidroterapia/métodos
Levantamento de Peso/fisiologia
[Mh] Termos MeSH secundário: Atletas
Creatina Quinase/sangue
Estudos Transversais
Exercício/fisiologia
Alemanha
Humanos
Hidrocortisona/sangue
Masculino
Movimento/fisiologia
Testosterona/sangue
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 3XMK78S47O (Testosterone); EC 2.7.3.2 (Creatine Kinase); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1519/JSC.0000000000001591


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[PMID]:28401840
[Au] Autor:Mulder RH; Rijlaarsdam J; Luijk MP; Verhulst FC; Felix JF; Tiemeier H; Bakermans-Kranenburg MJ; Van Ijzendoorn MH
[Ad] Endereço:Leiden University.
[Ti] Título:Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation.
[So] Source:Dev Psychopathol;29(2):491-503, 2017 May.
[Is] ISSN:1469-2198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The parent-child attachment relationship plays an important role in the development of the infant's stress regulation system. However, genetic and epigenetic factors such as FK506 binding protein 51 (FKBP5) genotype and DNA methylation have also been associated with hypothalamus-pituitary-adrenal axis functioning. In the current study, we examined how parent-child dyadic regulation works in concert with genetic and epigenetic aspects of stress regulation. We study the associations of attachment, extreme maternal insensitivity, FKBP5 single nucleotide polymorphism 1360780, and FKBP5 methylation, with cortisol reactivity to the Strange Situation Procedure in 298 14-month-old infants. The results indicate that FKBP5 methylation moderates the associations of FKBP5 genotype and resistant attachment with cortisol reactivity. We conclude that the inclusion of epigenetics in the field of developmental psychopathology may lead to a more precise picture of the interplay between genetic makeup and parenting in shaping stress reactivity.
[Mh] Termos MeSH primário: Metilação de DNA/fisiologia
Epigênese Genética/fisiologia
Hidrocortisona/metabolismo
Comportamento Materno/fisiologia
Apego ao Objeto
Estresse Psicológico/metabolismo
Proteínas de Ligação a Tacrolimo/metabolismo
[Mh] Termos MeSH secundário: Feminino
Genótipo
Humanos
Lactente
Masculino
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 5.2.1.- (Tacrolimus Binding Proteins); EC 5.2.1.8 (tacrolimus binding protein 5); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1017/S095457941700013X


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[PMID]:28391126
[Au] Autor:Tarullo AR; St John AM; Meyer JS
[Ad] Endereço:Department of Psychological and Brain Sciences, Boston University, United States. Electronic address: atarullo@bu.edu.
[Ti] Título:Chronic stress in the mother-infant dyad: Maternal hair cortisol, infant salivary cortisol and interactional synchrony.
[So] Source:Infant Behav Dev;47:92-102, 2017 May.
[Is] ISSN:1934-8800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Stress physiology is shaped by early experience, with enduring effects on health. The relation of chronic maternal physiological stress, as indexed by hair cortisol, to infants' stress systems and to mother-infant interaction quality has not been established. We examined maternal hair and salivary cortisol, six-month-old infants' salivary cortisol, and mother-infant interaction in 121 mother-infant dyads. High maternal hair cortisol was related to higher infant average salivary cortisol concentration. Maternal hair cortisol and bedtime salivary cortisol were both uniquely related to infant bedtime salivary cortisol. Mothers with higher hair cortisol were more intrusive and had lower positive engagement synchrony with their infants. Maternal intrusiveness moderated the association of maternal hair cortisol and infant salivary cortisol, such that maternal hair and infant average salivary cortisol were related only when mothers were more intrusive. Maternal chronic physiological stress may upregulate infants' developing stress systems, particularly in the context of lower mother-infant interaction quality.
[Mh] Termos MeSH primário: Cabelo/metabolismo
Hidrocortisona/metabolismo
Relações Mãe-Filho/psicologia
Mães/psicologia
Saliva/metabolismo
Estresse Fisiológico/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Humanos
Lactente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170409
[St] Status:MEDLINE


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[PMID]:28302942
[Au] Autor:Sotohira Y; Suzuki K; Sano T; Arai C; Asakawa M; Hayashi H
[Ad] Endereço:School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.
[Ti] Título:Stress assessment using hair cortisol of kangaroos affected by the lumpy jaw disease.
[So] Source:J Vet Med Sci;79(5):852-854, 2017 May 03.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to objectively assess stress of kangaroos affected by lumpy jaw disease (LJD) using plasma and hair cortisol concentrations. The plasma and hair samples were collected from kangaroos with LJD and healthy controls. Collected hair samples were extracted with methanol after washing with isopropanol, following which they were processed with the cortisol enzyme immunoassay kit. The plasma cortisol concentration of LJD animals tended to be higher than that of the control. Ventral hair cortisol, but not dorsal hair, of LJD animals was significantly higher than that of the control. In conclusion, stress in kangaroos infected with LJD could be assessed by measuring ventral hair cortisol.
[Mh] Termos MeSH primário: Cabelo/química
Hidrocortisona/análise
Doenças Maxilomandibulares/veterinária
Macropodidae
Osteomielite/veterinária
Estresse Fisiológico
[Mh] Termos MeSH secundário: Animais
Hidrocortisona/sangue
Doenças Maxilomandibulares/diagnóstico
Osteomielite/diagnóstico
Osteomielite/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.16-0633


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[PMID]:28158433
[Au] Autor:Keyes KM; Susser E
[Ti] Título:Invited Commentary: An Ingenious Approach to Examining the Relationship Between Maternal Stress and Offspring Health?
[So] Source:Am J Epidemiol;185(5):329-332, 2017 03 01.
[Is] ISSN:1476-6256
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The potentially deleterious effects on offspring health of excess maternal stress in pregnancy are important to understand-both whether observed associations are causal and through what mechanisms their effects may exert an influence. In this issue of the Journal, Räikkönen et al. (Am J Epidemiol. 2012;000(0):000-000) provide an ingenious test of a potential pathway through which maternal stress may influence offspring development. Licorice consumption is known to disrupt the ability of the placental enzyme 11ß-hydroxysteroid dehydrogenase type 2 to inactivate cortisol before it reaches the fetus, leading to higher levels of cortisol exposure. Higher levels of cortisol exposure are also hypothesized to underlie the mechanism through which maternal stress may disrupt fetal development. Thus licorice consumption may serve, in some ways, to mimic maternal stress. The authors report associations between heavy licorice consumption during pregnancy and a wide range of offspring outcomes, including changes in pubertal timing, intelligence quotient, and mental health. In our view, these results should be considered preliminary; more work needs to be completed to determine the relationship of prenatal licorice consumption to these outcomes. Nonetheless, these intriguing and suggestive results demonstrate that this line of work should be given high priority, and they set the stage for additional research moving forward.
[Mh] Termos MeSH primário: 11-beta-Hidroxiesteroide Desidrogenase Tipo 2
Hidrocortisona
[Mh] Termos MeSH secundário: Feminino
Desenvolvimento Fetal
Humanos
Saúde Mental
Placenta/enzimologia
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenase Type 2); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1093/aje/kww173


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[PMID]:28033218
[Au] Autor:Papadakis GZ; Millo C; Karantanas AH; Bagci U; Patronas NJ
[Ad] Endereço:From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center (CC), Bethesda; †PET Department, Clinical Center, National Institutes of Health (NIH), Bethesda, MD; ‡Department of Radiology, Medical School, University of Crete, Crete, Greece; and §Center for Research in Computer Vision (CRCV), Electrical and Computer Science Department, University of Central Florida (UCF), Orlando, FL.
[Ti] Título:Avascular Necrosis of the Hips With Increased Activity on 68Ga-DOTATATE PET/CT.
[So] Source:Clin Nucl Med;42(3):214-215, 2017 Mar.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prolonged exposure to cortisol is one of the major causes of avascular bone necrosis (AVN). We report on a case of a woman with Cushing syndrome attributed to ectopic adrenocorticotropic hormone-secreting tumor who was evaluated with whole-body PET/CT study using Ga-DOTATATE. The scan showed increased activity by both femoral heads, corresponding to the margins of bilateral AVN seen on MRI. The presented data suggests AVN-induced reactive inflammatory alterations adjacent to the necrotic segment of the bone, which can be effectively targeted using radiolabeled somatostatin (SST) analogs.
[Mh] Termos MeSH primário: Compostos Organometálicos
Osteonecrose/diagnóstico por imagem
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Compostos Radiofarmacêuticos
[Mh] Termos MeSH secundário: Feminino
Quadril/diagnóstico por imagem
Humanos
Hidrocortisona/efeitos adversos
Meia-Idade
Osteonecrose/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organometallic Compounds); 0 (Radiopharmaceuticals); 9L17Y0H71P (dotatate gallium ga-68); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0000000000001513


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[PMID]:27776604
[Au] Autor:De Andrés-García S; Cano-López I; Moya-Albiol L; González-Bono E
[Ad] Endereço:Universitat de València.
[Ti] Título:Negative affect, perceived health, and endocrine and immunological levels in caregivers of offspring with schizophrenia.
[So] Source:Psicothema;28(4):377-382, 2016 Nov.
[Is] ISSN:1886-144X
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Negative affect (NA) and chronic stress are separately associated with health imbalances, and the interaction between the two aspects remains unclear. Care of relatives with long-term pathologies could be a likely model in the study of this issue, as caregivers frequently report chronic stress and health complaints. The aim of this study is examine the role of NA on psychophysiological stress-induced response and health in schizophrenia caregivers. METHOD: Forty-one caregivers were distributed into two groups accordingly to their scores in NA. Thirteen non-caregivers were included as a control group. Participants were exposed to a repeated acute psychosocial stress while salivary cortisol, immunoglobulin A (IgA), and skin conductance level (SCL) were measured before, during, and after stress. Mood, state-anxiety, care conditions and perceived general health were also assessed. RESULTS: Caregivers with higher NA reported negative perceptions, worse health, and greater decreases in cortisol and IgA response than caregivers with low NA and than non-caregivers. CONCLUSIONS: NA could reduce the capability to develop adaptive psychophysiological stress responses. From a preventive view, the evaluation of NA could be useful to detect and assist high-risk individuals in potentially chronically stressed populations.
[Mh] Termos MeSH primário: Afeto
Atitude Frente à Saúde
Cuidadores/psicologia
Pais/psicologia
Esquizofrenia
Estresse Psicológico
[Mh] Termos MeSH secundário: Adulto
Anticorpos
Feminino
Resposta Galvânica da Pele
Humanos
Hidrocortisona/análise
Masculino
Saliva/química
Estresse Psicológico/imunologia
Estresse Psicológico/metabolismo
Estresse Psicológico/fisiopatologia
Estresse Psicológico/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde