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[PMID]:28958609
[Au] Autor:Matcan S; Sanabria Carretero P; Gómez Rojo M; Castro Parga L; Reinoso-Barbero F
[Ad] Endereço:Departamento de Anestesiología, Reanimación y Cuidados Críticos, Hospital Universitario Infantil La Paz, Madrid, España. Electronic address: snejana86@yahoo.com.
[Ti] Título:The importance of bilateral monitoring of cerebral oxygenation (NIRS): Clinical case of asymmetry during cardiopulmonary bypass secondary to previous cerebral infarction.
[Ti] Título:Importancia de la monitorización bilateral de la oxigenación cerebral: caso clínico de asimetría durante el bypass cardiopulmonar secundaria a infarto cerebral previo..
[So] Source:Rev Esp Anestesiol Reanim;, 2017 Sep 25.
[Is] ISSN:2340-3284
[Cp] País de publicação:Spain
[La] Idioma:eng; spa
[Ab] Resumo:Cerebral oximetry based on near infrared spectroscopy (NIRS) technology is used to determine cerebral tissue oxygenation. We hereby present the clinical case of a 12-month old child with right hemiparesis secondary to prior left middle cerebral artery stroke 8 months ago. The child underwent surgical enlargement of the right ventricular outflow tract (RVOT) with cardiopulmonary bypass. During cardiopulmonary bypass, asymmetric NIRS results were detected between both hemispheres. The utilization of multimodal neuromonitoring (NIRS-BIS) allowed acting on both perfusion pressure and anesthetic depth to balance out the supply and demand of cerebral oxygen consumption. No new neurological sequelae were observed postoperatively. We consider bilateral NIRS monitoring necessary in order to detect asymmetries between cerebral hemispheres. Although asymmetries were not present at baseline, they can arise intraoperatively and its monitoring thus allows the detection and treatment of cerebral ischemia-hypoxia in the healthy hemisphere, which if undetected and untreated would lead to additional neurological damage.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[St] Status:Publisher


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[PMID]:28674292
[Au] Autor:Hirohata S; Inagaki J; Ohtsuki T
[Ad] Endereço:Department of Medical Technology, Graduate School of Health Sciences, Okayama University.
[Ti] Título:Diverse Functions of a Disintegrin and Metalloproteinase with Thrombospondin Motif-1.
[So] Source:Yakugaku Zasshi;137(7):811-814, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A disintegrin and metalloproteinase with thrombospondin motif-1 (ADAMTS1) was initially cloned from a colon cachexia cell line. In the last 20 years, novel matrix metalloproteinase (MMP) genes were found, and in addition to their original members (MMPs and membrane-type MMPs), the current MMP family contains a disintegrin and metalloproteinases (ADAMs) and ADAMTS. ADAM and ADAMTS play essential roles in organogenesis as well as various diseases including osteoarthritis. ADAMTS has 19 members and can be divided into several groups according to their substrates. ADAMTS1, the first member of ADAMTS identified, is located on chromosome 21 very close to another ADAMTS member, ADAMTS5. Interestingly, ADAMTS1 is not highly expressed in normal tissues. One stimulation such as inflammation quickly induces ADAMTS1 expression. We found that hypoxia induced ADAMTS1 expression in endothelial cells, and serum ADAMTS1 levels were elevated in acute myocardial infarction patients. Once the artery was reperfused, the serum ADAMTS1 level quickly returned to the normal level. We also found that ADAMTS1 has specific roles in angiogenesis and lymphangiogenesis, and these functions were not related to its protease activity. It is also interesting that ADAMTS1 is likely to have a unique role in the tumor microenvironment. We also analyzed ADAMTS1-deficient mice and the results suggested that ADAMTS1 has diverse biological functions.
[Mh] Termos MeSH primário: Proteína ADAMTS1/fisiologia
[Mh] Termos MeSH secundário: Proteína ADAMTS1/classificação
Proteína ADAMTS1/genética
Animais
Matriz Extracelular/metabolismo
Expressão Gênica
Humanos
Linfangiogênese/genética
Camundongos
Infarto do Miocárdio/genética
Neovascularização Fisiológica/genética
Organogênese/genética
Osteoartrite/genética
Microambiente Tumoral/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
EC 3.4.24.- (ADAMTS1 Protein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.16-00236-4


  3 / 190344 MEDLINE  
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[PMID]:28536064
[Au] Autor:Park CK; Jung NY; Kim M; Chang JW
[Ad] Endereço:Department of Neurosurgery, Severance Hospital, Brain Research Institute, Yonsei University, College of Medicine, Seoul, Korea.
[Ti] Título:Analysis of Delayed Intracerebral Hemorrhage Associated with Deep Brain Stimulation Surgery.
[So] Source:World Neurosurg;104:537-544, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Deep brain stimulation (DBS) may cause various complications including intracerebral hemorrhage (ICH). Because ICH causes devastating neurologic outcomes, various surgical techniques are attempting to reduce the chances of ICH. More importantly, early detection and proper management of postoperative ICH are indispensable. ICH may occur immediately or delayed following DBS; in this study, we analyzed the clinical features of delayed ICH after DBS. METHODS: Patients (n = 272) underwent postoperative brain computed tomography (CT) immediately after and 1 day after DBS between January 2008 and November 2016. Among these patients, 136 patients had Parkinson disease, 54 suffered from dystonia, 47 presented with essential tremor, and 9 had obsessive-compulsive disorder. RESULTS: Out of the 272 patients who underwent 448 DBS lead implantations, 13 patients showed postoperative ICH. The ICH rate was 2.9% per lead and 4.77% per patient during the study period. Three patients (1.1%) demonstrated ICH immediately after DBS, and 10 patients (3.7%) demonstrated delayed ICH. Among them, only 1 patient showed large ICH (30 cm ) with elevation of intracranial pressure, subsequently undergoing ICH removal surgery and recovering without permanent neurologic deficits. The other 12 patients demonstrated small ICH (1-10 cm ). None of the patients with ICH demonstrated permanent disability. CONCLUSIONS: Our study demonstrates that delayed ICH can occur after DBS even with normal brain CT immediately after DBS. Because ICH can cause serious neurological sequelae, the possibility of delayed ICH after DBS should be considered for the optimal management of patients.
[Mh] Termos MeSH primário: Hemorragia Cerebral/etiologia
Estimulação Encefálica Profunda/efeitos adversos
Distonia/cirurgia
Tremor Essencial/cirurgia
Transtorno Obsessivo-Compulsivo/cirurgia
Doença de Parkinson/cirurgia
Complicações Pós-Operatórias/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Assistência ao Convalescente
Idoso
Infarto Encefálico/diagnóstico por imagem
Infarto Encefálico/etiologia
Hemorragia Cerebral/diagnóstico por imagem
Criança
Feminino
Humanos
Hipertensão Intracraniana/diagnóstico por imagem
Hipertensão Intracraniana/etiologia
Masculino
Meia-Idade
Complicações Pós-Operatórias/diagnóstico por imagem
Fatores de Tempo
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


  4 / 190344 MEDLINE  
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[PMID]:28530455
[Au] Autor:Tomcsányi J
[Ti] Título:[Adherence to statins in patients with myocardial infarction in Hungary. [Orvosi Hetilap (2017; 158: 443-446.); DOI: 10.1556/650.2017.30687]].
[Ti] Título:Statin gyógyszerszedési gyakorlat myocardialis infarctus után Magyarországon. [Orvosi Hetilap (2017; 158: 443­446.); DOI: 10.1556/650.2017.30687]..
[So] Source:Orv Hetil;158(21):839, 2017 May.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Mh] Termos MeSH primário: Anticolesterolemiantes/uso terapêutico
Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico
Adesão à Medicação/estatística & dados numéricos
Infarto do Miocárdio/quimioterapia
[Mh] Termos MeSH secundário: Humanos
Hungria
Infarto do Miocárdio/mortalidade
Vigilância da População
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticholesteremic Agents); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30798


  5 / 190344 MEDLINE  
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[PMID]:28480373
[Au] Autor:Gong X
[Ad] Endereço:VIP Internal Medicine, No.1 Donggang West Road, Chengguan District, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China.
[Ti] Título:PROTECTIVE EFFECT OF ROXB IN MYOCARDIAL INFARCTION POST MESENCHYMAL STEM CELL TRANSPLANTATION: STUDY IN CHRONIC ISCHEMIC RAT MODEL.
[So] Source:Afr J Tradit Complement Altern Med;13(6):155-162, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Thia study evaluates the effects of Roxb methanolic extract (AER-ME) in rats induced with Myocardial Infarction (MI) followed by transplantation of MSCs. MATERIAL AND METHODS: Rats were induced with MI by ligation technique of left coronary artery. The sham-operated the control and AER-ME treated group of rats received transplantation of PKH-26 and marked MSCs followed by normal saline and AER-ME treatment (200mg/kg/day of AER-ME extract) respectively for 30 days. Parameters such as cardiac function, inflammation, oxidative stress, apoptosis and differentiation of MSCs (angiogenesis) were evaluated. Histological studies of infracted myocardium reveled anti-inflammatory activity of AER-ME treatment. RESULT AND DISCUSSION: Oxidative stress parameters revealed decrease in levels of malondialdehyde (MDA) and increase in superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHpx) activity significantly indicating antioxidant activity of the extract. There was a reduction in cell death rate of treated rats due to the decrease in apoptotic index with prolongation of MI when compared to both control and sham-operated groups. The expression of Fas protein was parallel to apoptotic index. The vascular density increased significantly in extract treated group. The treatment showed improved cardiac activity with decreased left ventricular end diastolic (LVEDP) and arterial pressure while the left ventricular end systolic pressure (LVEP) and dp/dtmax increased significantly when compared to both control and sham-operated groups respectively showing the protective effect of the extract as necessitated by the transplantation of MSCs. The study marked the protective outcomes of AER-ME treatment for MSCs in microenvironment of infracted myocardium by improving their viability and increasing differentiation into cardiomyocytes.
[Mh] Termos MeSH primário: Ailanthus/química
Metanol/farmacologia
Infarto do Miocárdio/quimioterapia
Fitoterapia/métodos
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Modelos Animais de Doenças
Coração/efeitos de drogas
Masculino
Transplante de Células-Tronco Mesenquimais/efeitos adversos
Infarto do Miocárdio/etiologia
Estresse Oxidativo/efeitos de drogas
Extratos Vegetais/química
Complicações Pós-Operatórias/quimioterapia
Complicações Pós-Operatórias/etiologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Protective Agents); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i6.22


  6 / 190344 MEDLINE  
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[PMID]:28189362
[Au] Autor:Shamliyan TA; Middleton M; Borst C
[Ad] Endereço:Evidence-Based Medicine Center, Quality Assurance, Elsevier, Philadelphia, Pennsylvania. Electronic address: t.shamliyan@elsevier.com.
[Ti] Título:Patient-centered Outcomes with Concomitant Use of Proton Pump Inhibitors and Other Drugs.
[So] Source:Clin Ther;39(2):404-427.e36, 2017 Feb.
[Is] ISSN:1879-114X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: We performed a systematic review of patient-centered outcomes after the concomitant use of proton pump inhibitors (PPIs) and other drugs. METHODS: We searched 4 databases in July 2016 to find studies that reported mortality and morbidity after the concomitant use of PPIs and other drugs. We conducted direct meta-analyses using a random-effects model and graded the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation working group approach. FINDINGS: We included data from 17 systematic reviews and meta-analyses, 16 randomized controlled trials, and 16 observational studies that examined the concomitant use of PPIs with medications from 10 drug classes. Low-quality evidence suggests that the use of PPIs is associated with greater morbidity when administered with antiplatelet drugs, bisphosphonates, antibiotics, anticoagulants, metformin, mycophenolate mofetil, or nelfinavir. Concomitant PPIs reduce drug-induced gastrointestinal bleeding and are associated with greater docetaxel and cisplatin response rates in patients with metastatic breast cancer. For demonstrated statistically significant relative risks and benefits from concomitant PPIs, the magnitudes of the effects are small, with <100 attributable events per 1000 patients treated, and the effects are inconsistent among specific drugs. Among individual PPIs, the concomitant use of pantoprazole or esomeprazole, but not omeprazole or lansoprazole, is associated with an increased risk for all-cause mortality, nonfatal myocardial infarction, or stroke. Clopidogrel is associated with a greater risk for myocardial infarction compared with prasugrel. Conflicting results between randomized controlled trials and observational studies and high risk for bias in the body of evidence lessened our confidence in the results. IMPLICATIONS: Available evidence suggests a greater risk for adverse patient outcomes after the concomitant use of PPIs and medications from 9 drug classes and warns against inappropriate drug combinations.
[Mh] Termos MeSH primário: Interações de Medicamentos
Inibidores da Bomba de Prótons/efeitos adversos
[Mh] Termos MeSH secundário: Hemorragia Gastrointestinal/induzido quimicamente
Hemorragia Gastrointestinal/prevenção & controle
Humanos
Infarto do Miocárdio/epidemiologia
Inibidores da Bomba de Prótons/administração & dosagem
Ensaios Clínicos Controlados Aleatórios como Assunto
Risco
Acidente Vascular Cerebral/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Proton Pump Inhibitors)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE


  7 / 190344 MEDLINE  
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[PMID]:28090005
[Au] Autor:Yoshimura H; Oba T; Nagata T; Kumagai E; Itaya N; Yoshikawa N; Akagaki D; Ohshima H; Nishihara M; Ueno T; Fukumoto Y
[Ad] Endereço:Department of Medicine, Kurume University School of Medicine.
[Ti] Título:Unstable Angina Pectoris in a 22-year-old Female Patient.
[So] Source:Kurume Med J;63(1.2):33-37, 2017 Apr 13.
[Is] ISSN:1881-2090
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Because of the protective effect of estrogen for atherosclerosis, the prevalence of acute coronary syndrome in women before menopause is low. We report a rare case of unstable angina in a young Japanese female who had a history of cigarette smoking and contraceptive use. Her coronary stenosis was successfully treated by percutaneous coronary intervention.
[Mh] Termos MeSH primário: Angina Instável/diagnóstico
Intervenção Coronária Percutânea/métodos
[Mh] Termos MeSH secundário: Angina Instável/cirurgia
Anticoncepcionais Orais/efeitos adversos
Angiografia Coronária
Doença da Artéria Coronariana/diagnóstico
Doença da Artéria Coronariana/cirurgia
Feminino
Humanos
Japão
Hábito de Fumar
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contraceptives, Oral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170116
[St] Status:MEDLINE
[do] DOI:10.2739/kurumemedj.MS6300008


  8 / 190344 MEDLINE  
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[PMID]:28034517
[Au] Autor:Hirayama K; Ota T; Harada K; Shibata Y; Tatami Y; Harata S; Kawashima K; Kunimura A; Shimbo Y; Takayama Y; Kawamiya T; Yamamoto D; Osugi N; Suzuki S; Ishii H; Murohara T
[Ad] Endereço:Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
[Ti] Título:Impact of Paradoxical Decrease in High-density Lipoprotein Cholesterol Levels After Statin Therapy on Major Adverse Cardiovascular Events in Patients with Stable Angina Pectoris.
[So] Source:Clin Ther;39(2):279-287, 2017 Feb.
[Is] ISSN:1879-114X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Statin therapy usually increases HDL-C levels. However, a paradoxical decrease in HDL-C levels after statin therapy is often seen in clinical settings. The relationship between a paradoxical decrease in HDL-C levels after statin therapy and adverse cardiovascular events in patients with stable angina pectoris (SAP) is not well understood. The purpose of this study was to analyze the relationship between paradoxical HDL-C decreases after statin therapy and major adverse cardiovascular events (MACEs) in patients undergoing percutaneous coronary intervention (PCI) for SAP. METHODS: Between January 2006 and March 2015, 867 patients underwent PCI for SAP. Of them, we enrolled 209 patients who were newly started on statin therapy before PCI. We excluded patients who had started statin therapy earlier than 6 months before PCI, patients who had not started statin therapy after PCI, and patients who were diagnosed with acute coronary syndrome. They were divided into 2 groups according to the change in their HDL-C levels between baseline and 6 to 9 months after the index PCI: decreased HDL group after statin treatment (80 patients) and increased HDL group (129 patients). The primary end points were MACEs defined as a composite of all-cause death, nonfatal acute myocardial infarction, and target vessel revascularization (TVR). FINDINGS: Using Kaplan-Meier analysis, the 7-year event rate for composite MACEs in the decreased HDL group was found to be higher than that for the increased HDL group (38% versus 24%, log-rank P = 0.02). TVR occurred more frequently in the decreased HDL group than in the increased HDL group (32% versus 12%, log-rank P = 0.01). With the use of multivariate analysis, changes in HDL-C levels after statin therapy indicated a significant inverse association with the increased risk of MACEs, (hazard ratio [HR] = 0.94; 95% CI, 0.92-0.97; P < 0.01). The incidence of MACEs was more strongly associated with ΔHDL than with ΔLDL. Moreover, BMS usage also independently predicted MACEs (HR = 2.18; 95% CI, 1.14-4.17; P < 0.01). IMPLICATIONS: A paradoxical decrease in HDL-C levels after statin therapy might be a risk factor for MACEs, especially TVR, in patients with SAP.
[Mh] Termos MeSH primário: Síndrome Coronariana Aguda/quimioterapia
Angina Estável/quimioterapia
HDL-Colesterol/sangue
Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Feminino
Humanos
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Infarto do Miocárdio/epidemiologia
Intervenção Coronária Percutânea/métodos
Modelos de Riscos Proporcionais
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholesterol, HDL); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE


  9 / 190344 MEDLINE  
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[PMID]:28930854
[Au] Autor:Wang A; Li X; Dookhun MN; Zhang T; Xie P; Cao Y
[Ad] Endereço:aDepartment of Cardiology, Gansu Provincial Hospital bSchool of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou cDepartment of Intensive Care, Minhang Hospital, Fudan University, Shanghai dDepartment of Cardiology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
[Ti] Título:A female patient with hypokalaemia-induced J wave syndrome: An unusual case report.
[So] Source:Medicine (Baltimore);96(38):e8098, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Prominent J waves can be seen in life-threatening cardiac arrhythmias such as Brugada syndrome, early repolarization syndrome, and ventricular fibrillation. We herein present an unusual case report of hypokalemia-induced J wave syndrome and ST (a part of ECG) segment elevation. PATIENTS CONCERNS: A 52-year-old woman with chief complaints of chest pain for 2 hours and diarrhea showed a marked hypokalemia (2.8 mmol/L) and slightly elevated creatine kinase-MB (CK-MB) (57.5 U/L). The electrocardiographic (ECG) recording was normal upon admission and computed tomography (CT) aorta angiography excluded an aorta dissection. ECG done 17 hours after admission showed ST segment elevation and elevated J wave in leads II, III and aVF, and fusion of T and U wave in all leads. DIAGNOSIS: We first thought that the diagnosis of this patient was acute myocardial syndrome. INTERVENTION: Potassium chloride and oflocaxin treatment was given to the patient. OUTCOMES: Laboratory test showed the level of serum potassium ion increased to 3.4 mmol/L and CK-MB did not have any significant change. The infusion of potassium chloride-induced disappearance of the elevated J wave, although QT (a part of ECG) intervals were still longer than that upon admission. LESSONS: This case tells us that hypokalaemia might induce J wave and elevated ST segments which should be distinguished from acute myocardial syndrome.
[Mh] Termos MeSH primário: Arritmias Cardíacas/diagnóstico
Arritmias Cardíacas/etiologia
Hipopotassemia/complicações
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Arritmias Cardíacas/quimioterapia
Dor no Peito/etiologia
Diagnóstico Diferencial
Eletrocardiografia
Feminino
Humanos
Hipopotassemia/quimioterapia
Levofloxacino/uso terapêutico
Meia-Idade
Infarto do Miocárdio/diagnóstico
Cloreto de Potássio/uso terapêutico
Soluções para Reidratação/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Rehydration Solutions); 660YQ98I10 (Potassium Chloride); 6GNT3Y5LMF (Levofloxacin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008098


  10 / 190344 MEDLINE  
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[PMID]:28930837
[Au] Autor:Zhang X; Wang Z; Wang Z; Fang M; Shu Z
[Ad] Endereço:Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
[Ti] Título:The prognostic value of shock index for the outcomes of acute myocardial infarction patients: A systematic review and meta-analysis.
[So] Source:Medicine (Baltimore);96(38):e8014, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Several studies have revealed that high shock index (SI) is a risk factor for acute myocardial infarction (AMI) patients. These studies do not give a systematic review in this issue. Therefore, we conducted a systematic review and meta-analysis to determine the effect of high SI on the prognosis of AMI patients. METHODS: We did a systematic search of PubMed, Embase, and the Cochrane Library, using various combinations of keywords such as "shock index," "shock-index," "acute myocardial infarction," "ST elevation myocardial infarction," "non-ST segment elevation myocardial infarction," "STEMI," "NSTEMI," "AMI," and "MI" for eligible studies published up to December 23, 2016. The 3 primary outcomes for this analysis were all-cause in-hospital mortality, short-term adverse outcomes, and long-term adverse outcomes. RESULTS: Database searches retrieved 226 citations. Finally, 8 studies enrolling 20,404 patients were eventually included in the analysis. High SI was associated with an increased in-hospital mortality (pooled RR = 10.96, 95% CI: 2.00-59.94, P = .01). Adverse outcomes were significantly higher in the high SI group compared to the low SI group (pooled RR = 1.93, 95% CI: 1.10-3.39, P = .02; I = 95%). Individuals with high SI had an increased risk of long-term adverse outcomes (pooled RR = 2.31, 95% CI: 1.90-2.81, P < .001) compared to low SI. CONCLUSION: High SI may increase the in-hospital mortality, short-term, and long-term adverse outcomes in AMI patients.
[Mh] Termos MeSH primário: Pressão Sanguínea
Frequência Cardíaca
Infarto do Miocárdio/mortalidade
Choque Cardiogênico/diagnóstico
[Mh] Termos MeSH secundário: Mortalidade Hospitalar
Humanos
Infarto do Miocárdio/fisiopatologia
Prognóstico
Choque Cardiogênico/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008014



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