Base de dados : MEDLINE Pesquisa : Lycopodium [Palavras] Referências encontradas : 258 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 23270499 [Au] Autor: Bradshaw B; Luque-Corredera C; Bonjoch J [Ad] Endereço: Laboratori de Química Orgánica, Facultat de Farmàcia, IBUB, Universitat de Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Spain. benbradshaw@ub.edu [Ti] Título: cis-Decahydroquinolines via asymmetric organocatalysis: application to the total synthesis of lycoposerramine Z. [So] Source: Org Lett;15(2):326-9, 2013 Jan 18. [Is] ISSN: 1523-7052 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A concise synthesis of the Lycopodium alkaloid lycoposerramine Z is reported. Key to the strategy is a one-pot organocatalyzed Michael reaction followed by a domino Robinson annulation/intramolecular aza-Michael reaction promoted by LiOH, leading to enantiopure cis-decahydroquinolines. [Mh] Termos MeSH primário: Alcaloides/síntese química Óxidos N-Cíclicos/síntese química Quinolinas/síntese química [Mh] Termos MeSH secundário: Alcaloides/química Óxidos N-Cíclicos/química Lycopodium/química Estrutura Molecular Quinolinas/química Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Alkaloids); 0 (Cyclic N-Oxides); 0 (Quinolines); 0 (lycoposerramine-Z); 77823-96-2 (decahydroquinoline-5-carboxylic acid) [Em] Mês de entrada: 1305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130118 [St] Status: MEDLINE [do] DOI: 10.1021/ol303257y

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[PMID]: 23454433 [Au] Autor: Ma T; Gong K; Yan Y; Zhang L; Tang P; Zhang X; Gong Y [Ad] Endereço: State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China. [Ti] Título: Huperzine A promotes hippocampal neurogenesis in vitro and in vivo. [So] Source: Brain Res;1506:35-43, 2013 Apr 19. [Is] ISSN: 1872-6240 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Huperzine A (Hup A) is a lycopodium alkaloid from Huperzia serrata, which has been used as a therapeutic agent in several neurological disorders. Despite the diverse pharmacological activities Hup A has, its role in hippocampal neurogenesis remains to be established. This study showed that Hup A not only promoted the proliferation of cultured mouse embryonic hippocampal neural stem cells (NSCs), but also increased the newly generated cells in the subgranular zone (SGZ) of the hippocampus in adult mice. Furthermore, the in vitro findings indicated that low concentrations of Hup A stimulated the proliferation of cultured NSCs, whereas extremely high concentration of it decreased the cell proliferation. Hup A activated mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway, which was a well-known regulator of biological processes including cell proliferation and differentiation. ERK inhibitor dramatically inhibited the proliferative effect of Hup A on NSCs. Administration of Hup A to adult mice significantly enhanced the cell proliferation in dentate gyrus of hippocampus, and increased the remaining newborn cells 4 weeks after the drug administration. Moreover, the newly generated BrdU(+)/NeuN(+) neurons were also increased by Hup A treatment. These findings suggest a novel role of Hup A in neurogenesis and provide a new insight into its therapeutic effects in neurological disorders via a neurogenesis-related mechanism. [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1304 [Sb] Subgrupo de revista: IM [St] Status: In-Process

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[PMID]: 23622263 [Au] Autor: Nayak C; Oberai P; Varanasi R; Baig H; Ch R; Reddy GR; Devi P; S B; Singh V; Singh VP; Singh H; Shitanshu SS [Ad] Endereço: Central Council for Research in Homoeopathy, New Delhi, India. [Ti] Título: A prospective multi-centric open clinical trial of homeopathy in diabetic distal symmetric polyneuropathy. [So] Source: Homeopathy;102(2):130-8, 2013 Apr. [Is] ISSN: 1476-4245 [Cp] País de publicação: Scotland [La] Idioma: eng [Ab] Resumo: OBJECTIVES: To evaluate homeopathic treatment in the management of diabetic distal symmetric polyneuropathy. METHODS: A prospective multi-centric clinical observational study was carried out from October 2005 to September 2009 by Central Council for Research in Homeopathy (CCRH) (India) at its five Institutes/Units. Patients suffering from diabetes mellitus (DM) and presenting with symptoms of diabetic polyneuropathy (DPN) were screened, investigated and were enrolled in the study after fulfilling the inclusion and exclusion criteria. Patients were evaluated by the Diabetic Distal Symmetric Polyneuropathy Symptom Score (DDSPSS) developed by the Council. A total of 15 homeopathic medicines were identified after repertorizing the nosological symptoms and signs of the disease. The appropriate constitutional medicine was selected and prescribed in 30, 200 and 1 M potency on an individualized basis. Patients were followed up regularly for 12 months. RESULTS: Out of 336 patients (167 males and 169 females) enrolled in the study, 247 patients (123 males and 124 females) were analyzed. All patients who attended at least three follow-up appointments and baseline curve conduction studies were included in the analysis.). A statistically significant improvement in DDSPSS total score (p = 0.0001) was found at 12 months from baseline. Most objective measures did not show significant improvement. Lycopodium clavatum (n = 132), Phosphorus (n = 27) and Sulphur (n = 26) were the medicines most frequently prescribed. Adverse event of hypoglycaemia was observed in one patient only. CONCLUSION: This study suggests homeopathic medicines may be effective in managing the symptoms of DPN patients. Further studies should be controlled and include the Quality of life (QOL) assessment. [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1304 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review

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[PMID]: 23022390 [Au] Autor: Konrath EL; Neves BM; Passos Cdos S; Lunardi PS; Ortega MG; Cabrera JL; Gonçalves CA; Henriques AT [Ad] Endereço: Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. edukonrath@yahoo.com.br [Ti] Título: Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain. [So] Source: Phytomedicine;19(14):1321-4, 2012 Nov 15. [Is] ISSN: 1618-095X [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Huperzine A, a Lycopodium alkaloid produced by Chinese folk herb Huperzia serrata (Lycopodiaceae), has been shown to be a promising agent for the treatment of Alzheimer's disease due to its potent acetylcholinesterase (AChE) activity, as well its efficacy in the treatment of memory of aged patients. Thus, the effects of two Huperzia species of habitats in Brazil (H. quadrifariata and H. reflexa) with described in vitro AChE inhibition activities were studied and their effects on mice brain AChE inhibition were determined after a single intraperitoneal (i.p.) injection. The alkaloid extracts were administered to mice in various doses (10, 1 and 0.5mg/kg) and acetylcholinesterase activity was measured post mortem in two brain areas using the Ellman's colorimetric method. The AChE activity was found to be significantly reduced in both the cortex and hippocampus, although this activity was less potent than that of reference inhibitor huperzine A (0.5mg/kg). Thus, it appears that H. quadrifariata and H. reflexa alkaloid extracts, shown to inhibit acetylcholinesterase in vitro, also have very potent in vivo effects, suggesting that the Huperzia species may still constitute a promising source of compounds with pharmaceutical interest for Alzheimer's disease. [Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo Alcaloides/farmacologia Doença de Alzheimer/metabolismo Encéfalo/efeitos de drogas Inibidores da Colinesterase/farmacologia Huperzia/química Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Alcaloides/uso terapêutico Doença de Alzheimer/quimioterapia Animais Encéfalo/metabolismo Córtex Cerebral/efeitos de drogas Inibidores da Colinesterase/uso terapêutico Hipocampo/efeitos de drogas Injeções Intraperitoneais Masculino Camundongos Camundongos Endogâmicos Fitoterapia Extratos Vegetais/uso terapêutico Sesquiterpenos/farmacologia Sesquiterpenos/uso terapêutico [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Alkaloids); 0 (Cholinesterase Inhibitors); 0 (Plant Extracts); 0 (Sesquiterpenes); 0111871I23 (huperzine A); EC 3.1.1.7 (Acetylcholinesterase) [Em] Mês de entrada: 1304 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 121126 [St] Status: MEDLINE

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[PMID]: 22924746 [Au] Autor: Zhang XM; Shao H; Tu YQ; Zhang FM; Wang SH [Ad] Endereço: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, PR China. [Ti] Título: Total syntheses of (+)-alopecuridine, (+)-sieboldine A, and (-)-lycojapodine A. [So] Source: J Org Chem;77(18):8174-81, 2012 Sep 21. [Is] ISSN: 1520-6904 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: (+)-Alopecuridine, (+)-sieboldine A, and (-)-lycojapodine A, three structurally unique and related lycopodium alkaloids, have been synthesized in enantiomeric forms through an efficient strategy. The main synthetic approach for (+)-alopecuridine features a semipinacol rearrangement of hydroxyl epoxide to construct the spiro 6,9-azacarbocycles with an all-carbon quaternary center and a late-stage SmI(2)-mediated intramolecular coupling to form the 5-membered ring. Subsequently, the biomimetic synthesis of (+)-sieboldine A and (-)-lycojapodine A was accomplished successfully through two different bioinspired oxidations after a wide search for the oxidation methods. As a result, (+)-sieboldine A was derived from (+)-alopecuridine through an N-oxidation/nitrone formation process and (-)-lycojapodine A through an interesting cyclic hemiketal formation/oxidative diol cleavage pathway. These results confirmed the biogenetic relationship among the three alkaloids. [Mh] Termos MeSH primário: Alcaloides/química Alcaloides/síntese química Compostos de Epóxi/química Compostos Heterocíclicos de 4 ou mais Anéis/química Compostos Heterocíclicos de 4 ou mais Anéis/síntese química Óxidos de Nitrogênio/química Compostos de Espiro/química [Mh] Termos MeSH secundário: Estrutura Molecular Oxirredução Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Alkaloids); 0 (Epoxy Compounds); 0 (Heterocyclic Compounds with 4 or More Rings); 0 (Nitrogen Oxides); 0 (Spiro Compounds); 0 (alopecuridine); 0 (lycojapodine A); 0 (nitrones); 0 (sieboldine A) [Em] Mês de entrada: 1304 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 120921 [St] Status: MEDLINE

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[PMID]: 22746970 [Au] Autor: Calderón AI; Simithy-Williams J; Sanchez R; Espinosa A; Valdespino I; Gupta MP [Ad] Endereço: Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, 4306B Walker Building, Auburn, AL 36849, USA. aic0001@auburn.edu [Ti] Título: Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors. [So] Source: Nat Prod Res;27(4-5):500-5, 2013 Mar. [Is] ISSN: 1478-6427 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Acetylcholinesterase (AChE) inhibitors have been used for the symptomatic treatment of Alzheimer's disease. Eleven whole plants from Panama belonging to the Lycopodiaceae family have been screened for their anticholinesterase inhibitory and antioxidant activities by a thin-layer chromatography (TLC) bioautography method. Of these, only Lycopodium clavatum subsp. clavatum showed strong AChE inhibition. Seven plant extracts showed moderate inhibition, two of them, Huperzia cf chamaeleon and Huperzia reflexa, also possessed an antioxidant activity. This is the first report of anticholinesterase and antioxidant activities in these two native plants. Additionally, alkaloid extracts of the Lycopodiaceae plants were also analysed by TLC and LC-MS to identify the well-known AchE inhibitor, huperzine A. Two plants, H. cf chamaeleon and H. reflexa var. minor, showed the presence of huperzine. [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1303 [Sb] Subgrupo de revista: IM [St] Status: In-Process [do] DOI: 10.1080/14786419.2012.701217

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[PMID]: 23384410 [Au] Autor: Saha M; Carter RG [Ad] Endereço: Department of Chemistry, 153 Gilbert Hall, Oregon State University, Corvallis, Oregon 97331, United States. [Ti] Título: Toward a unified approach for the lycopodines: synthesis of 10-hydroxylycopodine, deacetylpaniculine, and paniculine. [So] Source: Org Lett;15(4):736-9, 2013 Feb 15. [Is] ISSN: 1523-7052 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The enantioselective syntheses of 10-hydroxylycopodine, deacetylpaniculine, and paniculine have been accomplished through use of a common intermediate. Key steps in the synthetic sequence toward these lycopodium alkaloids include formation of the tricyclic core via a conformationally accelerated, intramolecular Mannich cyclization and an organocatalyzed, intramolecular Michael addition to form the C(7)-C(12) linkage. [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1302 [Sb] Subgrupo de revista: IM [St] Status: In-Process [do] DOI: 10.1021/ol303272w

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[PMID]: 23273261 [Au] Autor: Pigza JA; Han JS; Chandra A; Mutnick D; Pink M; Johnston JN [Ad] Endereço: Department of Chemistry & Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235-1822, USA. [Ti] Título: Total synthesis of the Lycopodium alkaloid serratezomine A using free radical-mediated vinyl amination to prepare a ß-stannyl enamine linchpin. [So] Source: J Org Chem;78(3):822-43, 2013 Feb 1. [Is] ISSN: 1520-6904 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Serratezomine A is a member of the structurally diverse class of compounds known as the Lycopodium alkaloids. The key supporting studies and successful total synthesis of serratezomine A are described in this account. Significant features of the synthesis include the first application of free radical mediated vinyl amination and Hwu's oxidative allylation in a total synthesis and an intramolecular lactonization via a transannular S(N)i reaction. Minimal use of protecting groups and the highly diastereoselective formation of a hindered, quaternary stereocenter using an umpolung allylation are also highlights from a strategy perspective. Observation of quaternary carbon epimerization via a retro-Mannich/Mannich sequence highlights the additional challenge presented by the axial alcohol at C8 in serratezomine A. [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Em] Mês de entrada: 1302 [Sb] Subgrupo de revista: IM [St] Status: In-Process [do] DOI: 10.1021/jo302333s

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[PMID]: 23345165 [Au] Autor: Burshtein G; Friedman M; Greenberg S; Hoffman A [Ad] Endereço: Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. [Ti] Título: Transepithelial transport of a natural cholinesterase inhibitor, huperzine A, along the gastrointestinal tract: the role of ionization on absorption mechanism. [So] Source: Planta Med;79(3-4):259-65, 2013 Mar. [Is] ISSN: 1439-0221 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: During recent years there has been increasing interest in the Lycopodium alkaloid huperzine A as a potential therapeutic agent for neurodegenerative diseases. This study aimed to characterize huperzine A's permeability across the enterocyte barrier along the gastrointestinal tract with an emphasis on the effect of ionization on the drug absorption. Intestinal permeability of huperzine A was evaluated by in vitro Caco-2 and parallel artificial membrane permeation assay models and by the ex vivo Ussing chamber model. The permeability rate was strongly dependent on the degree of ionization and increased with elevation of the donor medium pH in all studied models. The transport of the unionized fraction was similar to the permeability of the markers for passive transcellular diffusion. Addition of the paracellular permeability modulator palmitoylcarnitine in the Caco-2 model led to significant enhancement in the permeability of the ionized huperzine A fraction. No evidence of active transport of huperzine A was detected in this study. The Ussing chamber model experiments showed similar drug permeability along the entire rat intestine. In conclusion, huperzine A permeates the intestinal border mainly by passive transcellular diffusion whereas some fraction, dependent on the degree of huperzine A ionization, is absorbed by the paracellular route. Huperzine A's permeability characteristics pave the way to the development of its oral extended release dosage form. The specific population of the potential users of huperzine A and the high potency of this molecule support the rationale for such a delivery. [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1303 [Sb] Subgrupo de revista: IM [St] Status: In-Process [do] DOI: 10.1055/s-0032-1328128

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[PMID]: 23124675 [Au] Autor: Vallejo MG; Cifuente DA; Cecati FM; Ortega MG; Cabrera JL; Martín VS; Tonn CE; Agnese AM; Ardanaz CE [Ti] Título: Mass spectrometry studies of Lycopodium alkaloid sauroine. [So] Source: Rapid Commun Mass Spectrom;26(23):2827-31, 2012 Dec 15. [Is] ISSN: 1097-0231 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Alcaloides/química Lycopodium/química [Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas Íons/química Espectrometria de Massas em Tandem [Pt] Tipo de publicação: LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Alkaloids); 0 (Ions); 0 (sauroine) [Em] Mês de entrada: 1304 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 121105 [St] Status: MEDLINE [do] DOI: 10.1002/rcm.6380

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