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Pesquisa : Papulose and Linfomatóide [Palavras]
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[PMID]:22688398
[Au] Autor:Cardoso J; Duhra P; Thway Y; Calonje E
[Ad] Endereço:Dermatopathology Department, St. John's Institute of Dermatology, London, UK.
[Ti] Título:Lymphomatoid papulosis type D: a newly described variant easily confused with cutaneous aggressive CD8-positive cytotoxic T-cell lymphoma.
[So] Source:Am J Dermatopathol;34(7):762-5, 2012 Oct.
[Is] ISSN:1533-0311
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lymphomatoid papulosis (LyP) is defined as a chronic recurrent skin disease characterized by waxing and waning papules and nodules with histologic features of a CD30-positive T-cell lymphoma. Three histological subtypes (A, B, and C) were already recognized, and only more recently, a further variant simulating histologically an aggressive epidermotropic CD8-positive T-cell lymphoma was described, which was named LyP type D by the authors. We report the case of a 38-year-old woman presenting with a 1-year history of recurrent self-healing papules and nodules, predominantly affecting her upper and lower limbs but also the face, including the lower lip, with no associated systemic symptoms. A biopsy from 1 lesion revealed an infiltrate of atypical lymphoid cells extending throughout the dermis with massive epidermotropism displaying a pagetoid reticulosis-like pattern and a CD8(+)CD30(+) cytotoxic T-cell phenotype. The clinicopathologic features conformed to the newly described type D variant of LyP. Diagnostic studies did not reveal any systemic involvement, and the patient remains otherwise well with no active treatment. In the present report, we discuss the need for clinicopathologic correlation to establish an accurate diagnosis and its importance for an adequate management of these patients.
[Mh] Termos MeSH primário: Linfoma Cutâneo de Células T/patologia
Papulose Linfomatoide/patologia
Neoplasias Cutâneas/patologia
Pele/patologia
Linfócitos T Citotóxicos/patologia
[Mh] Termos MeSH secundário: Adulto
Antígenos CD30/análise
Marcadores Biológicos/análise
Biópsia
Diagnóstico Diferencial
Feminino
Rearranjo Gênico do Linfócito T
Humanos
Imunoistoquímica
Linfoma Cutâneo de Células T/imunologia
Papulose Linfomatoide/classificação
Papulose Linfomatoide/genética
Papulose Linfomatoide/imunologia
Fenótipo
Valor Preditivo dos Testes
Recidiva
Pele/imunologia
Neoplasias Cutâneas/classificação
Neoplasias Cutâneas/genética
Neoplasias Cutâneas/imunologia
Linfócitos T Citotóxicos/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD30); 0 (Biological Markers)
[Em] Mês de entrada:1302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120924
[St] Status:MEDLINE


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[PMID]:23026936
[Au] Autor:Kempf W; Kazakov DV; Schärer L; Rütten A; Mentzel T; Paredes BE; Palmedo G; Panizzon RG; Kutzner H
[Ad] Endereço:Kempf und Pfaltz, Histologische Diagnostik, Zürich, Switzerland. werner.kempf@access.uzh.ch
[Ti] Título:Angioinvasive lymphomatoid papulosis: a new variant simulating aggressive lymphomas.
[So] Source:Am J Surg Pathol;37(1):1-13, 2013 Jan.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lymphomatoid papulosis (LyP) belongs to the spectrum of primary cutaneous CD30-positive lymphoproliferative disorders. Clinically, LyP is characterized by a variable number of self-healing papulo-nodular lesions, with the typical waxing and waning course. Histologically, 4 types (A, B, C, and D) have been delineated. Angioinvasive growth and large ulcers are rare findings in LyP and simulate aggressive lymphoma. We retrospectively analyzed the clinicopathologic and molecular features of angioinvasive LyP in a series of 16 patients. This new form of LyP is characterized by oligolesional papules that rapidly ulcerate and evolve into large necrotic eschar-like lesions with a diameter of 1 to 4 cm and an angiocentric and angiodestructive infiltrate of small-sized to medium-sized atypical lymphocytes expressing CD30 and frequently CD8. As in other forms of LyP, the lesions underwent spontaneous regression after a few weeks. Recurrences were common, but the prognosis was excellent with no extracutaneous spread or disease-related deaths. Complete remission occurred in 9 of 16 patients (56%). This LyP variant should be distinguished from aggressive forms of angiocentric and angiodestructive and cytotoxic T-cell lymphomas. We propose the term LyP type E for this clinically and histologically unusual variant.
[Mh] Termos MeSH primário: Papulose Linfomatoide/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Antígenos CD30/metabolismo
Linfócitos T CD8-Positivos/metabolismo
Linfócitos T CD8-Positivos/patologia
Criança
Diagnóstico Diferencial
Progressão da Doença
Feminino
Humanos
Papulose Linfomatoide/genética
Masculino
Meia-Idade
Invasividade Neoplásica
Regressão Neoplásica Espontânea
Indução de Remissão
Estudos Retrospectivos
Neoplasias Cutâneas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD30)
[Em] Mês de entrada:1302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121217
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0b013e3182648596


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[PMID]:23297527
[Au] Autor:Jaeger T; Plötz SG; Shamizadeh S; Zirbs M; Ring J; Hein R; Ollert M; Andres C
[Ad] Endereço:Klinik und Poliklinik für Dermatologie und Allergologie der Technischen Universität München, Biedersteiner Str. 29, D-80802 München.
[Ti] Título:[Periorbital ulceration. Herpes? Lues? Neoplasia?].
[Ti] Título:Periorbitale ulzeration. Herpes? Lues? Neoplasie?.
[So] Source:MMW Fortschr Med;154(22):5, 2012 Dec 17.
[Is] ISSN:1438-3276
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Neoplasias Palpebrais/diagnóstico
Papulose Linfomatoide/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Biópsia
Diagnóstico Diferencial
Neoplasias Palpebrais/patologia
Herpes Simples/diagnóstico
Herpes Simples/patologia
Humanos
Papulose Linfomatoide/patologia
Pele/patologia
Neoplasias Cutâneas/patologia
Sífilis Cutânea/diagnóstico
Sífilis Cutânea/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130109
[St] Status:MEDLINE


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[PMID]:22715829
[Au] Autor:Criscuoli V; Rizzuto MR; Cottone M
[Ad] Endereço:Dibimis (Biomedical Department of Internal and Specialistic Medicine), V.Cervello Hospital Palermo, University of Palermo, Palermo, Italy. vale.cic@tiscali.it
[Ti] Título:A rare case of ulcerative proctitis associated with type B lymphomatoid papulosis and superimposed human cytomegalovirus infection.
[So] Source:Int J Dermatol;51(7):838-9, 2012 Jul.
[Is] ISSN:1365-4632
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por Citomegalovirus/complicações
Papulose Linfomatoide/complicações
Proctite/complicações
[Mh] Termos MeSH secundário: Adulto
Anti-Inflamatórios não Esteroides/uso terapêutico
Humanos
Papulose Linfomatoide/quimioterapia
Papulose Linfomatoide/patologia
Masculino
Mesalamina/uso terapêutico
Terapia PUVA
Proctite/quimioterapia
Proctite/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 89-57-6 (Mesalamine)
[Em] Mês de entrada:1212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120621
[St] Status:MEDLINE
[do] DOI:10.1111/j.1365-4632.2011.05011.x


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[PMID]:22334164
[Au] Autor:Tokuriki A; Kiyohara T; Ido T; Kumakiri M
[Ti] Título:A case of lymphomatoid papulosis with extensive limb disease followed by extracutaneous involvement and acquired ichthyosis.
[So] Source:Acta Derm Venereol;92(3):278-9, 2012 May.
[Is] ISSN:1651-2057
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Mh] Termos MeSH primário: Papulose Linfomatoide/terapia
Recidiva Local de Neoplasia/terapia
Neoplasias Cutâneas/terapia
[Mh] Termos MeSH secundário: Adulto
Humanos
Ictiose/complicações
Metástase Linfática
Papulose Linfomatoide/complicações
Papulose Linfomatoide/patologia
Masculino
Recidiva Local de Neoplasia/patologia
Neoplasias Cutâneas/complicações
Neoplasias Cutâneas/patologia
Coxas
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120608
[St] Status:MEDLINE
[do] DOI:10.2340/00015555-1314


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[PMID]:22472952
[Au] Autor:Kempf W; Kazakov DV; Palmedo G; Fraitag S; Schaerer L; Kutzner H
[Ad] Endereço:Kempf und Pfaltz Histologische Diagnostik, Seminarstrasse 1, CH-8042 Zurich, Switzerland. kempf@kempf-pfaltz.ch
[Ti] Título:Pityriasis lichenoides et varioliformis acuta with numerous CD30(+) cells: a variant mimicking lymphomatoid papulosis and other cutaneous lymphomas. A clinicopathologic, immunohistochemical, and molecular biological study of 13 cases.
[So] Source:Am J Surg Pathol;36(7):1021-9, 2012 Jul.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pityriasis lichenoides comprises a clinicopathologic spectrum of cutaneous inflammatory disorders, with the 2 most common variants being pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica. The aim of the study was to describe 13 cases of a unique PLEVA variant characterized in the conspicuous CD30 component and thus mimicking lymphomatoid papulosis (LyP), a condition currently classified in the spectrum of CD30 lymphoproliferative disorders. The cohort included 10 female and 3 male patients whose ages at diagnosis ranged from 7 to 89 years (mean 41 y; median 39 y). The clinical manifestation was that of PLEVA, with small erythematous macules quickly evolving into necrotic papules. No waxing and waning was seen on follow-up in any of the cases. Histopathologically, typical features of PLEVA were present, but an unusual finding was occurrence of a considerable number of CD30 small lymphocytes as detected immunohistochemically. Over half of the cases also displayed a large number of CD8 cells and showed coexpression of CD8 and CD30 in the intraepidermal and dermal component of the infiltrate. Of the 11 cases of PLEVA studied for T-cell receptor gene rearrangement, 6 evidenced a monoclonal T-cell population, and 5 were polyclonal. Parvovirus B19 (PVB19) DNA was identified in 4 of 10 cases investigated, and positive serology was observed for PVB19 in 2 patients, altogether suggesting that PVB19 is pathogenetically linked to PLEVA at least in a subset of cases. The presence of CD30 lymphocytes and CD8 lymphocytes would be consistent with an inflammatory antiviral response, as CD30, even atypically appearing lymphoid cells have been identified in some viral skin diseases. The main significance of the PLEVA variant is, however, its potential confusion with LyP or some cytotoxic lymphomas. Admittedly, the CD30 PLEVA variant described herein and LyP show considerable overlap if one takes into account all known variations of the 2 conditions recognized in recent years, thus suggesting that LyP and PLEVA may be much more biologically closely related entities than currently thought or can even occur on a clinicopathologic spectrum.
[Mh] Termos MeSH primário: Antígenos CD30/análise
Linfócitos T CD8-Positivos/imunologia
Imunoistoquímica
Papulose Linfomatoide/diagnóstico
Pitiríase Liquenoide/diagnóstico
Reação em Cadeia da Polimerase
Neoplasias Cutâneas/diagnóstico
Pele/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anticorpos Antivirais/sangue
Marcadores Biológicos/análise
Linfócitos T CD8-Positivos/patologia
Linfócitos T CD8-Positivos/virologia
Estudos de Casos e Controles
Criança
DNA Viral/isolamento & purificação
Diagnóstico Diferencial
Feminino
Rearranjo Gênico do Linfócito T
Genes Codificadores dos Receptores de Linfócitos T
Humanos
Papulose Linfomatoide/genética
Papulose Linfomatoide/imunologia
Papulose Linfomatoide/patologia
Papulose Linfomatoide/virologia
Masculino
Meia-Idade
Parvovirus B19 Humano/genética
Parvovirus B19 Humano/imunologia
Pitiríase Liquenoide/genética
Pitiríase Liquenoide/imunologia
Pitiríase Liquenoide/patologia
Pitiríase Liquenoide/virologia
Valor Preditivo dos Testes
Pele/patologia
Pele/virologia
Neoplasias Cutâneas/genética
Neoplasias Cutâneas/imunologia
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Antigens, CD30); 0 (Biological Markers); 0 (DNA, Viral)
[Em] Mês de entrada:1209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120629
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0b013e31824f4f66


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[PMID]:22261676
[Au] Autor:Fernández-Guarino M; Carrillo-Gijón R; Jaén-Olasolo P
[Ad] Endereço:Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain. montsefdez@msn.com
[Ti] Título:[Lymphomatoid papulosis: clinical and pathological findings in 18 patients].
[Ti] Título:Papulosis linfomatoide: hallazgos clínico-patológicos en 18 pacientes..
[So] Source:Actas Dermosifiliogr;103(5):388-93, 2012 Jun.
[Is] ISSN:1578-2190
[Cp] País de publicação:Spain
[La] Idioma:spa
[Ab] Resumo:BACKGROUND: Lymphomatoid papulosis (LyP) is a CD30(+) lymphoproliferative skin disease that has been described in association with Hodgkin lymphoma. It has also been reported to progress to mycosis fungoides or cutaneous anaplastic large-cell lymphoma. OBJECTIVE: To study the clinical and histologic features of LyP and response to treatment in a patient series. MATERIALS AND METHODS: For this retrospective, descriptive, observational study of patients with histologically confirmed LyP and sufficient follow-up data on record, we extracted histologic findings on skin biopsy, clinical presentation, clinical course, and response to treatments. RESULTS: Eighteen patients (10 male, 8 female) were identified. Most biopsies (14/18, 78%) showed a wedge-shaped lymphocytic infiltrate with CD30(+), CD3(+), and CD56(-) cells. A type A histologic pattern was present in the biopsies of 83% of the patients. The most common presentation (83%) consisted of papules on the trunk; for 62% LyP resolved after a single episode. Twelve percent of the patients developed mycosis fungoides (mean follow-up, 7 years); no other associations were noted. DISCUSSION: Although few series of patients with LyP have been published in recent years, the findings reported generally coincide with our observations. CONCLUSION: LyP is typically a CD30(+) lymphoproliferative disorder that usually runs a benign course and responds well to treatment.
[Mh] Termos MeSH primário: Papulose Linfomatoide/imunologia
Papulose Linfomatoide/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Feminino
Humanos
Imunoistoquímica
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120528
[St] Status:MEDLINE
[do] DOI:10.1016/j.ad.2011.08.007


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[PMID]:21982062
[Au] Autor:de Souza A; el-Azhary RA; Camilleri MJ; Wada DA; Appert DL; Gibson LE
[Ad] Endereço:Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
[Ti] Título:In search of prognostic indicators for lymphomatoid papulosis: a retrospective study of 123 patients.
[So] Source:J Am Acad Dermatol;66(6):928-37, 2012 Jun.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lymphomatoid papulosis (LyP) is a benign recurrent papulonodular skin eruption with histologically malignant features that sometimes (10%-20%) progresses to lymphoma. OBJECTIVE: We retrospectively evaluated the clinical course of patients with LyP and identify prognostic factors possibly indicating a malignant course. METHODS: Clinical, histopathologic, and immunologic features and molecular genetics were examined and correlated with clinical course and outcomes. Immunophenotyping and chemokine profiling were performed in select skin biopsy samples. A follow-up questionnaire was sent to patients. Clinical course and association with neoplastic disorders were correlated with LyP subtypes, molecular genetics, and immunophenotyping studies. RESULTS: Of 123 patients with LyP (1991-2008) followed up a mean of 4 years (range, 2 months to 14 years), 17 (14%) had an associated hematologic malignancy, 8 of which were mycosis fungoides. Histopathologic analyses demonstrated classic LyP type A (n = 69), B (n = 13), or C (n = 6), and a slight predominance of T-cell CD8 marker expression for type A. More than one type of lesion was present in 9 patients with a higher incidence of hematologic malignancies. T-cell receptor gene rearrangement positivity was about two times higher, with LyP associated with hematologic malignancy (82% vs 44%; odds ratio 5.7; P = .02). Chemokine studies in a subset of 25 patients showed chemokine receptor (CCR) CCR4(+) and thymus and activation-related chemokine (TARC(+)) in all LyP types and CCR3(+) and chemokine-related receptor (CXCR) CXCR3(+) in types B and C. LIMITATIONS: Retrospective study design is a limitation. CONCLUSIONS: Positive T-cell receptor gene rearrangement or diagnosis of mixed-type LyP may be a prognostic indicator of disease more prone to progress to lymphoma.
[Mh] Termos MeSH primário: Transformação Celular Neoplásica/genética
Rearranjo Gênico do Linfócito T
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Transformação Celular Neoplásica/imunologia
Transformação Celular Neoplásica/patologia
Criança
Pré-Escolar
Progressão da Doença
Feminino
Perfilação da Expressão Gênica
Humanos
Papulose Linfomatoide/genética
Papulose Linfomatoide/imunologia
Masculino
Meia-Idade
Prognóstico
Receptores de Antígenos de Linfócitos T/genética
Estudos Retrospectivos
Neoplasias Cutâneas/genética
Neoplasias Cutâneas/imunologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Antigen, T-Cell)
[Em] Mês de entrada:1207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120515
[St] Status:MEDLINE
[do] DOI:10.1016/j.jaad.2011.07.012


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[PMID]:22353584
[Au] Autor:Cook V; Kho G
[Ad] Endereço:Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. vcook@ualberta.ca
[Ti] Título:Cutaneous lymphoma or benign lesion?
[So] Source:CMAJ;184(8):917, 2012 May 15.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Linfoma/diagnóstico
Papulose Linfomatoide/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Antebraço
Humanos
Linfoma/patologia
Papulose Linfomatoide/patologia
Masculino
Pele/patologia
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:120515
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.111569


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[PMID]:22515578
[Au] Autor:Eminger LA; Shinohara MM; Kim EJ; Heymann WR
[Ad] Endereço:Cooper University Hospital, NJ, USA. lindsayeminger@gmail.com
[Ti] Título:Clinicopathologic challenge: acral lymphomatoid papulosis.
[So] Source:Int J Dermatol;51(5):531-4, 2012 May.
[Is] ISSN:1365-4632
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Mãos
Papulose Linfomatoide/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Feminino
Humanos
Papulose Linfomatoide/quimioterapia
Meia-Idade
Neoplasias Cutâneas/quimioterapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120420
[St] Status:MEDLINE
[do] DOI:10.1111/j.1365-4632.2011.05303.x



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