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Pesquisa : Síndrome and De and Isaacs [Palavras]
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[PMID]:28552871
[Au] Autor:Mizuno Y; Yamaguchi H; Uehara T; Yamashita K; Yamasaki R; Kira JI
[Ad] Endereço:Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University.
[Ti] Título:A case of stiff-person syndrome due to secondary adrenal insufficiency.
[So] Source:Rinsho Shinkeigaku;57(6):298-302, 2017 06 28.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We report a case of flexion contractures in a patient's legs secondary to postpartum hypopituitarism. A 56-year-old woman presented with a 3-year history of worsening flexion contractures of the hips and knees. On admission, her hips and knees could not be extended, and she had muscle stiffness and tenderness to palpation of the lower extremities. We first suspected stiff-person syndrome or Isaacs' syndrome because of her muscle stiffness. However, multiple hormones did not respond to stimulation tests, and an MRI of the brain showed atrophy of the pituitary gland with an empty sella. A subsequent interview revealed that she had suffered a severe hemorrhage while delivering her third child. She was diagnosed with panhypopituitarism and started on cortisol replacement therapy. After 1 week of treatment with hydrocortisone (10 mg/day), her symptoms quickly improved. We then added 75 µg/day of thyroid hormone. During the course of her treatment, autoantibodies against VGKC complex were found to be weakly positive. However, we considered the antibodies to be unrelated to her disease, because her symptoms improved markedly with low-dose steroid treatment. There are a few reports describing flexion contractures of the legs in patients with primary and secondary adrenal insufficiency. As these symptoms are similar to those seen in stiff-person syndrome, adrenal and pituitary insufficiency should be taken into account to achieve the correct diagnosis and treatment in patients with flexion contractures and muscle stiffness.
[Mh] Termos MeSH primário: Hipopituitarismo/diagnóstico
Síndrome de Isaacs/diagnóstico
Rigidez Muscular Espasmódica/diagnóstico
[Mh] Termos MeSH secundário: Atrofia
Autoanticorpos/sangue
Biomarcadores/sangue
Diagnóstico Diferencial
Esquema de Medicação
Quimioterapia Combinada
Feminino
Seres Humanos
Hidrocortisona/administração & dosagem
Hipopituitarismo/diagnóstico por imagem
Hipopituitarismo/tratamento farmacológico
Meia-Idade
Hipófise/patologia
Hormônios Tireóideos/administração & dosagem
Tiroxina/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Biomarkers); 0 (Thyroid Hormones); Q51BO43MG4 (Thyroxine); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001008


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[PMID]:28235725
[Au] Autor:Santos MO; Swash M; de Carvalho M
[Ad] Endereço:Institute of Physiology Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Portugal; Department of Neurology, Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Portugal.
[Ti] Título:The generator site in acquired autoimmune neuromyotonia.
[So] Source:Clin Neurophysiol;128(4):643-646, 2017 Apr.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the origin of ectopic activity in neuromyotonia (NMT). METHODS: We studied two patients. In addition to routine studies, we tested synchronicity of spontaneous discharges in different motor units in simultaneous recordings made with two needle electrodes in the first dorsal interosseus muscle. Time-locked fasciculations in these double recordings would represent abnormal ectopic activity initiated in a nerve trunk with ephaptic stimulation of a nearby axon. In patient 1, this research protocol was applied once, 15years after regular intravenous immunoglobulin (IvIg) treatment. Patient 2 was investigated before and 1year after IvIg. RESULTS: Both patients improved after IVIg, mirrored by a striking decrease in the amount of spontaneous activity on electromyography. Moreover, our technique did not detect synchronous spontaneous activity (time-locked fasciculations) on the second assessment, although this was predominant before treatment in patient 2. CONCLUSIONS: In NMT, abnormal discharges originate both in distal axonal branches and in more proximal segments. It appears that IvIg is more effective in blocking antibody activity in proximal axonal segments, perhaps related to factors such as blood-nerve barrier, temperature or differing ion channel distributions. SIGNIFICANCE: Treatment effects can shed light on the origin of abnormal activity in NMT.
[Mh] Termos MeSH primário: Doenças Autoimunes/fisiopatologia
Fasciculação
Síndrome de Isaacs/fisiopatologia
Músculo Esquelético/inervação
[Mh] Termos MeSH secundário: Idoso
Doenças Autoimunes/diagnóstico
Doenças Autoimunes/terapia
Eletromiografia
Potencial Evocado Motor
Seres Humanos
Imunoglobulinas/administração & dosagem
Imunoglobulinas/uso terapêutico
Síndrome de Isaacs/diagnóstico
Síndrome de Isaacs/terapia
Masculino
Meia-Idade
Músculo Esquelético/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE


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[PMID]:28007994
[Au] Autor:Peeters K; Chamova T; Tournev I; Jordanova A
[Ad] Endereço:Molecular Neurogenomics Group, Department of Molecular Genetics, VIB and University of Antwerp, Antwerpen 2610, Belgium.
[Ti] Título:Axonal neuropathy with neuromyotonia: there is a HINT.
[So] Source:Brain;140(4):868-877, 2017 Apr 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Recessive mutations in the gene encoding the histidine triad nucleotide binding protein 1 (HINT1) were recently shown to cause a motor-predominant Charcot-Marie-Tooth neuropathy. About 80% of the patients exhibit neuromyotonia, a striking clinical and electrophysiological hallmark that can help to distinguish this disease and to guide diagnostic screening. HINT1 neuropathy has worldwide distribution and is particularly prevalent in populations inhabiting central and south-eastern Europe. With 12 different mutations identified in more than 60 families, it ranks among the most common subtypes of axonal Charcot-Marie-Tooth neuropathy. This article provides an overview of the present knowledge on HINT1 neuropathy with the aim to increase awareness and spur interest among clinicians and researchers in the field. We propose diagnostic guidelines to recognize and differentiate this entity and suggest treatment strategies to manage common symptoms. As a recent player in the field of hereditary neuropathies, the role of HINT1 in peripheral nerves is unknown and the underlying disease mechanisms are unexplored. We provide a comprehensive overview of the structural and functional characteristics of the HINT1 protein that may guide further studies into the molecular aetiology and treatment strategies of this peculiar Charcot-Marie-Tooth subtype.
[Mh] Termos MeSH primário: Doença de Charcot-Marie-Tooth/genética
Neuropatia Hereditária Motora e Sensorial/genética
Síndrome de Isaacs/genética
Miotonia/genética
Proteínas do Tecido Nervoso/genética
Doenças do Sistema Nervoso Periférico/genética
[Mh] Termos MeSH secundário: Doença de Charcot-Marie-Tooth/epidemiologia
Doença de Charcot-Marie-Tooth/patologia
Neuropatia Hereditária Motora e Sensorial/epidemiologia
Neuropatia Hereditária Motora e Sensorial/patologia
Seres Humanos
Síndrome de Isaacs/epidemiologia
Síndrome de Isaacs/patologia
Miotonia/epidemiologia
Miotonia/patologia
Doenças do Sistema Nervoso Periférico/epidemiologia
Doenças do Sistema Nervoso Periférico/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (HINT1 protein, human); 0 (Nerve Tissue Proteins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.1093/brain/aww301


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[PMID]:27957617
[Au] Autor:Xiao F
[Ad] Endereço:Department of Neurology, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1st You Yi Road, Chongqing, 400016, China. feixiao81@126.com.
[Ti] Título:Neuromyotonia as an unusual neurological complication of primary Sjögren's syndrome: case report and literature review.
[So] Source:Clin Rheumatol;36(2):481-484, 2017 Feb.
[Is] ISSN:1434-9949
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Primary Sjögren's syndrome (PSS) is a systemic autoimmune disorder characterized by chronic inflammation of exocrine glands such as the lachrymal and salivary glands, leading to xerophthalmia and xerostomia. Neurological manifestations are sometimes found in patients with PSS. A variety of neurological complications has been reported in patients with PSS, and both the central nervous system (CNS) and peripheral nervous system (PNS) can be involved in PSS. Several forms of neuropathy, including polyneuropathy, cranial neuropathy, and multiple mononeuropathy, are often seen in PSS patients. Herein, we report for the first time typical neuromyotonia (NMT) symptoms appearing in a patient with PSS. Neuromyotonia is a rare disorder caused by the hyperexcitability of peripheral nerves, causing spontaneous and continuous muscle contraction. We provide an overview of the literature relating to neurological involvement in PSS, and the etiology of acquired NMT. We also discuss the existence of contactin-associated protein-like 2 (Caspr2) antibodies in NMT patients.
[Mh] Termos MeSH primário: Doenças dos Nervos Cranianos/diagnóstico
Síndrome de Isaacs/diagnóstico
Doenças do Sistema Nervoso Periférico/diagnóstico
Síndrome de Sjogren/diagnóstico
[Mh] Termos MeSH secundário: Biópsia
Comorbidade
Doenças dos Nervos Cranianos/complicações
Feminino
Seres Humanos
Síndrome de Isaacs/complicações
Proteínas de Membrana/sangue
Proteínas do Tecido Nervoso/sangue
Doenças do Sistema Nervoso Periférico/complicações
Glândulas Salivares/fisiopatologia
Síndrome de Sjogren/complicações
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (CNTNAP2 protein, human); 0 (Membrane Proteins); 0 (Nerve Tissue Proteins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.1007/s10067-016-3499-z


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[PMID]:27769345
[Au] Autor:Khimdas S; Fraser JA
[Ad] Endereço:Western University, London, Ont. Electronic address: skhimdas@gmail.com.
[Ti] Título:Abducens neuromyotonia: a delayed neuro-ophthalmic complication of cranial radiation.
[So] Source:Can J Ophthalmol;51(5):e157-e158, 2016 Oct.
[Is] ISSN:1715-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças do Nervo Abducente/etiologia
Irradiação Craniana/efeitos adversos
Síndrome de Isaacs/etiologia
[Mh] Termos MeSH secundário: Doenças do Nervo Abducente/diagnóstico
Neoplasias Encefálicas/radioterapia
Diplopia/etiologia
Diplopia/fisiopatologia
Ependimoma/radioterapia
Seres Humanos
Síndrome de Isaacs/diagnóstico
Masculino
Músculos Oculomotores/inervação
Visão Binocular
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:27699467
[Au] Autor:Nardetto L; Briani C; Fedrigo M; Castellani C; Valente M; Polverino De Laureto P; Santelli L; Angelini A; Giometto B
[Ad] Endereço:Neurology, St Anthony Hospital, Padova, Italy. lucia.nardetto@gmail.com.
[Ti] Título:Isaacs' syndrome with overlapping myopathy as the first manifestation of AL amyloidosis.
[So] Source:J Neurol;263(11):2332-2335, 2016 Nov.
[Is] ISSN:1432-1459
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Amiloidose/complicações
Síndrome de Isaacs/patologia
[Mh] Termos MeSH secundário: Amiloidose/metabolismo
Amiloidose/patologia
Feminino
Glutamato Descarboxilase/metabolismo
Seres Humanos
Amiloidose de Cadeia Leve de Imunoglobulina
Síndrome de Isaacs/metabolismo
Proteínas de Membrana/metabolismo
Meia-Idade
Doenças Musculares
Miocárdio/patologia
Proteínas do Tecido Nervoso/metabolismo
Proteínas/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (CNTNAP2 protein, human); 0 (LGI1 protein, human); 0 (Membrane Proteins); 0 (Nerve Tissue Proteins); 0 (Proteins); EC 4.1.1.15 (Glutamate Decarboxylase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


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[PMID]:27653890
[Au] Autor:Takeda T; Konno A; Kazama T; Suzuki M; Shimizu Y; Iijima M; Tanaka J; Kitagawa K
[Ad] Endereço:Department of Neurology, Tokyo Women's Medical University, Japan. Electronic address: takahirotakeda58@yahoo.co.jp.
[Ti] Título:Acquired hemophilia A associated with myasthenia gravis and Isaacs' syndrome.
[So] Source:J Neurol Sci;369:210-211, 2016 Oct 15.
[Is] ISSN:1878-5883
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Hemofilia A/complicações
Síndrome de Isaacs/complicações
Miastenia Gravis/complicações
[Mh] Termos MeSH secundário: Idoso
Autoanticorpos/sangue
Hemofilia A/sangue
Seres Humanos
Síndrome de Isaacs/sangue
Masculino
Miastenia Gravis/sangue
Canais de Potássio de Abertura Dependente da Tensão da Membrana/imunologia
Receptores Colinérgicos/imunologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Potassium Channels, Voltage-Gated); 0 (Receptors, Cholinergic)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160923
[St] Status:MEDLINE


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[PMID]:27564076
[Au] Autor:Hardy TA; Lee AW; Yiannikas C; Chen CS; Reddel SW
[Ad] Endereço:*Neuroimmunology Clinic, Concord Hospital §ANZAC Research Institute, University of Sydney, Sydney, NSW Departments of †Neurology ‡Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, SA, Australia.
[Ti] Título:Extensive Postradiation Ocular and Diffuse Cranial Neuromyotonia Mimicking Myasthenia Gravis.
[So] Source:Neurologist;21(5):79-82, 2016 Sep.
[Is] ISSN:2331-2637
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ocular neuromyotonia is a rare, but well-recognized, complication of cranial irradiation. CASE REPORT: Using figures and videos, we report a 52-year-old man with extensive ocular, brainstem, and lower cranial nerve neuromyotonia postradiation therapy for a fourth ventricle glioma who, in the context of an apparently positive edrophonium test, was initially misdiagnosed with myasthenia gravis. CONCLUSIONS: This is the first case of postirradiation neuromyotonia to be reported with such extensive cranial nerve and brainstem involvement.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/radioterapia
Irradiação Craniana/efeitos adversos
Doenças dos Nervos Cranianos/diagnóstico
Erros de Diagnóstico
Glioma/radioterapia
Síndrome de Isaacs/diagnóstico
Miastenia Gravis/diagnóstico
Transtornos da Motilidade Ocular/diagnóstico
[Mh] Termos MeSH secundário: Encéfalo/diagnóstico por imagem
Doenças dos Nervos Cranianos/etiologia
Diagnóstico Diferencial
Seres Humanos
Síndrome de Isaacs/etiologia
Masculino
Meia-Idade
Transtornos da Motilidade Ocular/etiologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE
[do] DOI:10.1097/NRL.0000000000000088


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[PMID]:27428927
[Au] Autor:Joubert B; Saint-Martin M; Noraz N; Picard G; Rogemond V; Ducray F; Desestret V; Psimaras D; Delattre JY; Antoine JC; Honnorat J
[Ad] Endereço:Centre National de Référence pour les Syndromes Neurologiques Paranéoplasiques, Hôpital Neurologique, Hospices Civils de Lyon, Lyon, France.2Institut NeuroMyoGene, INSERM 1217/CNRS 5310, Université de Lyon, Lyon, France.3Université Claude-Bernard Lyon 1, Université de Lyon, Lyon, France.
[Ti] Título:Characterization of a Subtype of Autoimmune Encephalitis With Anti-Contactin-Associated Protein-like 2 Antibodies in the Cerebrospinal Fluid, Prominent Limbic Symptoms, and Seizures.
[So] Source:JAMA Neurol;73(9):1115-24, 2016 Sep 01.
[Is] ISSN:2168-6157
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IMPORTANCE: Autoantibodies against contactin-associated protein-like 2 (CASPR2) are observed in several neurological syndromes, including neuromyotonia (NMT), Morvan syndrome (MoS), and limbic encephalitis. OBJECTIVE: To characterize the clinical and biological presentations of patients with anti-CASPR2 antibodies in the cerebrospinal fluid (CSF). DESIGN, SETTING, AND PARTICIPANTS: We conducted a retrospective cohort analysis of 18 patients who had anti-CASPR2 antibodies in their CSF between March 2009 and November 2015 at the Centre National de Référence pour les Syndromes Neurologiques Paranéoplasiques in Lyon, France. Additionally, we analyzed 15 patients who were diagnosed as having NMT or MoS as a comparative group. MAIN OUTCOMES AND MEASURES: Clinical presentations, anti-CASPR2 antibodies specificities, brain magnetic resonance imaging, and CSF analyses, cancer prevalence, and evolution. RESULTS: In this cohort of 18 patients with anti-CASPR2 antibodies in their CSF, 17 (94.4%) were male and had a median (range) age of 64.5 (53-75) years; in the second group, 9 of 15 patients (60.0%) with NMT or MoS were male and had a median (range) age of 51 years (1 month to 75 years). Only 3 patients (16.7%) in this cohort had a previous or concomitant history of cancer (prostate, hematological, or thyroid), whereas 9 patients (60.0%) in the second group had a malignant thymoma. Symptoms of limbic encephalitis were observed in all patients, including temporal lobe seizures in 16 patients (88.9%) and memory disorders in 17 patients (94.4%) from the cohort. Extralimbic signs were also evident in 12 of 18 patients (66.7%), including cerebellar ataxia in 6 patients (33.3%). Only 2 patients (11.1%) from the cohort were diagnosed as having NMT. Brain magnetic resonance imaging displayed T2-weighted temporolimbic abnormalities in 14 of 15 patients (93.3%) in the second group. Cerebrospinal fluid analysis was abnormal in 9 of 12 patients (75.0%). For 16 of 18 patients (88.9%), follow-up was performed for at least a 6-month period (median [range], 34 [11-114] months). Of these, 15 (93.8%) improved and 6 (37.5%) relapsed. In all patients in this cohort, IgG4 autoantibodies were detected in the CSF. Anti-CASPR2 antibodies in the CSF targeted the laminin G1 and discoidin domains of CASPR2 in all patients. Importantly, anti-CASPR2 antibodies were detected in the serum but not in the CSF of all patients with NMT or MoS. CONCLUSIONS AND RELEVANCE: In this cohort study, anti-CASPR2 antibodies in the CSF are associated with a subtype of autoimmune encephalitis with prominent limbic involvement and seizures that is rarely associated with cancer. Conversely, patients with NMT and MoS have anti-CASPR2 antibodies only in the serum but not in the CSF and frequently present with a malignant thymoma. The anti-CASPR2 antibodies found in these patients targeted the discoidin and laminin G1 domains of CASPR2 and always included IgG4 autoantibodies.
[Mh] Termos MeSH primário: Autoanticorpos/líquido cefalorraquidiano
Encefalite Límbica/líquido cefalorraquidiano
Proteínas de Membrana/imunologia
Proteínas do Tecido Nervoso/imunologia
Convulsões/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: Idoso
Feminino
Seguimentos
França
Seres Humanos
Síndrome de Isaacs/líquido cefalorraquidiano
Síndrome de Isaacs/diagnóstico por imagem
Síndrome de Isaacs/tratamento farmacológico
Encefalite Límbica/complicações
Encefalite Límbica/diagnóstico por imagem
Encefalite Límbica/tratamento farmacológico
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Mioquimia/líquido cefalorraquidiano
Mioquimia/diagnóstico por imagem
Mioquimia/tratamento farmacológico
Estudos Retrospectivos
Convulsões/complicações
Convulsões/diagnóstico por imagem
Convulsões/tratamento farmacológico
Esteroides/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (CNTNAP2 protein, human); 0 (Membrane Proteins); 0 (Nerve Tissue Proteins); 0 (Steroids)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE
[do] DOI:10.1001/jamaneurol.2016.1585


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[PMID]:27254486
[Au] Autor:Belviranli M; Okudan N; Kabak B; Erdogan M; Karanfilci M
[Ad] Endereço:a Division of Sports Physiology, Department of Physiology, Faculty of Medicine , Selcuk University , Konya , Turkey.
[Ti] Título:The relationship between brain-derived neurotrophic factor, irisin and cognitive skills of endurance athletes.
[So] Source:Phys Sportsmed;44(3):290-6, 2016 09.
[Is] ISSN:2326-3660
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of this study was to assess the cognitive performance of endurance athletes and its relation with circulating brain-derived neurotrophic factor (BDNF) and irisin levels. METHODS: 26 endurance athletes (14 elite orienteers (mean ± SD: age = 26.33 ± 4.08, body weight = 70.33 ± 4.64, body height = 177.7 ± 6.1), 12 pentathletes (mean ± SD: age = 29.42 ± 5.32, body weight = 74.77 ± 6.59, body height = 180.8 ± 3.8)) and ten sedentary (mean ± SD: age = 27.30 ± 2.06, body weight = 76.65 ± 12.50, body height = 176.9 ± 5.2) men at almost same ages and educational levels participated in this study. Cognitive functions were analyzed with mini-mental-state examination (MMSE) and Isaacs' Set Test of Verbal Fluency (IST) tests. Insulin-like growth factor-1 (IGF-1), BDNF and irisin levels were measured in the blood samples. RESULTS: The MSSE and IST scores of the endurance athletes were higher than that of the sedentary control group (P < 0.05). Serum IGF-1 levels were higher in the pentathletes (111.18 ± 22.26 ng mL(-1)) than the orienteers (85.89 ± 19.32 ng mL(-1)) (P < 0.05). Plasma BDNF (2.78 ± 0.81, 4.28 ± 1.03, and 3.93 ± 0.77 ng mL(-1) in the sedentary, orienteers and pentathletes, respectively) and irisin (3.25 ± 0.70, 6.16 ± 0.99, and 6.58 ± 1.09 µg mL(-1) in the sedentary, orienteers and pentathletes, respectively) concentrations of the endurance trained athletes were higher than that of the sedentary control group (P < 0.05). Positive correlation between the cognitive function test results and BDNF and irisin concentrations were observed (P < 0.05). There was also a positive correlation between the circulating irisin and BDNF concentrations (P < 0.05). CONCLUSION: These results suggested that irisin and BDNF levels positively correlated with cognition in the endurance trained athletes.
[Mh] Termos MeSH primário: Atletas
Fator Neurotrófico Derivado do Encéfalo/sangue
Cognição
Fibronectinas/sangue
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Estudos Transversais
Seres Humanos
Fator de Crescimento Insulin-Like I/análise
Masculino
Testes Neuropsicológicos
Resistência Física
Estilo de Vida Sedentário
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (FNDC5 protein, human); 0 (Fibronectins); 0 (brain-derived neurotrophic factor, human); 67763-96-6 (Insulin-Like Growth Factor I)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170215
[Lr] Data última revisão:
170215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE
[do] DOI:10.1080/00913847.2016.1196125



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