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Pesquisa : S韓drome and de and Opsoclonia-Mioclonia [Palavras]
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[PMID]:28710878
[Au] Autor:Pranzatelli MR; Tate ED; Allison TJ
[Ad] Endere鏾:National Pediatric Neuroinflammation Organization, Inc., the National Pediatric Myoclonus Center, Orlando, FL, USA.
[Ti] T韙ulo:6-Mercaptopurine modifies cerebrospinal fluid T cell abnormalities in paediatric opsoclonus-myoclonus as steroid sparer.
[So] Source:Clin Exp Immunol;190(2):217-225, 2017 Nov.
[Is] ISSN:1365-2249
[Cp] Pa韘 de publica玢o:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to evaluate the capacity of 6-mercaptopurine (6-MP), a known immunosuppressant, to normalize cerebrospinal fluid (CSF) lymphocyte frequencies in opsoclonus-myoclonus syndrome (OMS) and function as a steroid sparer. CSF and blood lymphocytes were immunophenotyped in 11 children with OMS (without CSF B cell expansion) using a comprehensive panel of cell surface adhesion, activation and maturation markers by flow cytometry, and referenced to 18 paediatric controls. Drug metabolites, lymphocyte counts and liver function tests were used clinically to monitoring therapeutic range and toxicity. In CSF, adjunctive oral 6-MP was associated with a 21% increase in the low percentage of CD4 T cells in OMS, restoring the CD4/CD8 ratio. The percentage of CD4 T cells that were interferon (IFN)-纬 was reduced by 66%, shifting the cytokine balance away from T helper type 1 (Th1) (proinflammatory) predominance. The percentage of natural killer (NK) cells decreased significantly in CSF (-32%) and blood (-67 to -82%). Low blood absolute lymphocyte count was more predictive of improvement in CSF lymphocyte proportions (correlated with % CD4 T cells) than the 6-thioguanine level (no correlation). 6-MP was difficult to titrate: 50% achieved the target absolute lymphocyte count (<񁪍 K/mm); 20%, the 'therapeutic' 6-thioguanine level; and 40% the non-toxic 6-methylmercaptopurine level. Side effects and transaminase elevation were mild and reversible. Clinical steroid-sparing properties and lowered relapse frequency were demonstrated. 6-MP displayed unique pharmacodynamic properties that may be useful in OMS and other autoimmune disorders. Its steroid sparer capacity is limited to children in whom the therapeutic window can be reached without limiting pharmacokinetic factors or side effects.
[Mh] Termos MeSH prim醨io: Linf骳itos T CD4-Positivos/efeitos dos f醨macos
L韖uido Cefalorraquidiano/citologia
Mercaptopurina/farmacologia
S韓drome de Opsoclonia-Mioclonia/l韖uido cefalorraquidiano
[Mh] Termos MeSH secund醨io: Administra玢o Oral
Linf骳itos T CD4-Positivos/imunologia
Linf骳itos T CD4-Positivos/patologia
Linf骳itos T CD8-Positivos/imunologia
L韖uido Cefalorraquidiano/imunologia
Pr-Escolar
Feminino
Seres Humanos
Imunofenotipagem
Inflama玢o
Interferon gama/bioss韓tese
Interferon gama/imunologia
C閘ulas Matadoras Naturais/imunologia
Contagem de Linf骳itos
Masculino
Mercaptopurina/administra玢o & dosagem
Mercaptopurina/an醠ogos & derivados
Mercaptopurina/sangue
Mercaptopurina/farmacocin閠ica
Neuroblastoma/imunologia
C閘ulas Th1/imunologia
Tioguanina/sangue
Transaminases/sangue
[Pt] Tipo de publica玢o:JOURNAL ARTICLE
[Nm] Nome de subst鈔cia:
6V404DV25O (6-methylthiopurine); 82115-62-6 (Interferon-gamma); E7WED276I5 (Mercaptopurine); EC 2.6.1.- (Transaminases); FTK8U1GZNX (Thioguanine)
[Em] M阺 de entrada:1710
[Cu] Atualiza玢o por classe:171116
[Lr] Data 鷏tima revis鉶:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE
[do] DOI:10.1111/cei.13015


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[PMID]:28432174
[Au] Autor:Aquilina A; Dingli N; Aquilina J
[Ad] Endere鏾:Department of Neurosciences, Mater Dei Hospital, Attard, Malta.
[Ti] T韙ulo:Postintervention acute opsoclonus myoclonus syndrome.
[So] Source:BMJ Case Rep;2017, 2017 Apr 21.
[Is] ISSN:1757-790X
[Cp] Pa韘 de publica玢o:England
[La] Idioma:eng
[Ab] Resumo:Opsoclonus myoclonus syndrome (OMS) is a rare, neurological condition affecting 1 in 10 000 000 people annually. Opsoclonus, defined as involuntary rapid, multivectorial oscillations of the eyes, together with ataxia and myoclonus are usually present. OMS may be paraneoplastic: often associated with occult neuroblastoma in childhood and with breast carcinoma or small cell lung carcinoma in adults. Other aetiologies include viral or toxic agents. The pathogenesis is thought to be immune mediated. A 37-year-old woman with previous inflammatory cranial mononeuropathies was admitted for elective dilatation and curettage (D&C). Immediately after she complained of left-sided paraesthesia and later became disoriented, with incoherent speech, inability to obey commands, opsoclonus of the eyes and myoclonic jerks. Investigations including onconeuronal antibodies, cerebrospinal fluid analysis, and imaging were normal. She was treated with intravenous methylprednisolone with rapid improvement. Previous surgeries with anaesthesia were uncomplicated. The anaesthetic agents used for the D&C were fentanyl and propofol.
[Mh] Termos MeSH prim醨io: Metilprednisolona/administra玢o & dosagem
S韓drome de Opsoclonia-Mioclonia/diagn髎tico
[Mh] Termos MeSH secund醨io: Administra玢o Intravenosa
Adulto
Feminino
Seres Humanos
Metilprednisolona/uso terap陁tico
S韓drome de Opsoclonia-Mioclonia/tratamento farmacol骻ico
Resultado do Tratamento
[Pt] Tipo de publica玢o:JOURNAL ARTICLE
[Nm] Nome de subst鈔cia:
X4W7ZR7023 (Methylprednisolone)
[Em] M阺 de entrada:1706
[Cu] Atualiza玢o por classe:170613
[Lr] Data 鷏tima revis鉶:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE


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[PMID]:28102628
[Au] Autor:Miyoshi H; Nakamura R; Yamaga A; Haraki T; Yasuda T; Hamada H; Kawamoto M
[Ad] Endere鏾:Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima, Japan.
[Ti] T韙ulo:Transient symptomatic worsening by atropine in opsoclonus-myoclonus syndrome.
[So] Source:Pediatr Int;59(1):97-98, 2017 Jan.
[Is] ISSN:1442-200X
[Cp] Pa韘 de publica玢o:Australia
[La] Idioma:eng
[Ab] Resumo:Opsoclonus-myoclonus syndrome (OMS) is characterized by abnormal eye and systemic involuntary movements, as well as cerebellar ataxia. Some sedatives and anesthetics worsen movements associated with OMS, while there is no known report of a negative effect of atropine. We report on sedation in two patients with OMS. Involuntary movements were transiently worsened after using atropine with midazolam or thiamylal in both, but were not seen when atropine was not used. We speculated that atropine has the potential to exacerbate involuntary movements in OMS due to vulnerability to this agent via unknown mechanisms.
[Mh] Termos MeSH prim醨io: Adjuvantes Anest閟icos/efeitos adversos
Atropina/efeitos adversos
S韓drome de Opsoclonia-Mioclonia/induzido quimicamente
[Mh] Termos MeSH secund醨io: Anticonvulsivantes/uso terap陁tico
Pr-Escolar
Clonazepam/uso terap陁tico
Seda玢o Profunda/efeitos adversos
Seda玢o Profunda/m閠odos
Quimioterapia Combinada
Feminino
Glucocorticoides/uso terap陁tico
Seres Humanos
Lactente
Imagem por Resson鈔cia Magn閠ica
S韓drome de Opsoclonia-Mioclonia/diagn髎tico por imagem
S韓drome de Opsoclonia-Mioclonia/fisiopatologia
Prednisolona/uso terap陁tico
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publica玢o:CASE REPORTS
[Nm] Nome de subst鈔cia:
0 (Adjuvants, Anesthesia); 0 (Anticonvulsants); 0 (Glucocorticoids); 5PE9FDE8GB (Clonazepam); 7C0697DR9I (Atropine); 9PHQ9Y1OLM (Prednisolone)
[Em] M阺 de entrada:1705
[Cu] Atualiza玢o por classe:170510
[Lr] Data 鷏tima revis鉶:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1111/ped.13180


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[PMID]:28054126
[Au] Autor:Oh SY; Boegle R; Eulenburg PZ; Ertl M; Kim JS; Dieterich M
[Ad] Endere鏾:Department of Neurology, Chonbuk National University Hospital, School of Medicine, 20 Geonji-ro, Deokjin-gu, Jeonju-City, Chonbuk, 561-712, Korea. ohsun@jbnu.ac.kr.
[Ti] T韙ulo:Longitudinal multi-modal neuroimaging in opsoclonus-myoclonus syndrome.
[So] Source:J Neurol;264(3):512-519, 2017 Mar.
[Is] ISSN:1432-1459
[Cp] Pa韘 de publica玢o:Germany
[La] Idioma:eng
[Ab] Resumo:To investigate structural, metabolic, and functional connectivity changes in visual and oculomotor structures in a patient with paraneoplastic opsoclonus-myoclonus syndrome, serial resting-state functional and structural MRI, and FDG-PET data were collected during the acute stage and later on when the opsoclonus had resolved. In the acute stage, an FDG-PET scan demonstrated a substantially increased metabolism in structures around the deep cerebellar nuclei [e.g., fastigial nucleus (FN)] and a relatively reduced metabolism in the bilateral occipital lobes which normalized over 12爉onths. Functional connectivity increased initially between the seeds of the oculomotor and visual systems, including the primary and motion-sensitive visual cortex, frontal eye fields, superior colliculus, and cerebellar oculomotor vermis (OMV), and then decreased in the chronic stage as the symptoms resolved. The functional connectivity between the OMV and FN showed a positive correlation during the acute stage, which decreased later on. We provide a descriptive presentation of the changes of abnormal functional connectivity throughout visuo-oculomotor brain areas during opsoclonus and suggest directions for further research on the pathogenesis of opsoclonus.
[Mh] Termos MeSH prim醨io: Enc閒alo/diagn髎tico por imagem
Enc閒alo/fisiopatologia
Imagem por Resson鈔cia Magn閠ica
S韓drome de Opsoclonia-Mioclonia/diagn髎tico por imagem
S韓drome de Opsoclonia-Mioclonia/fisiopatologia
Tomografia por Emiss鉶 de P髎itrons
[Mh] Termos MeSH secund醨io: Mapeamento Encef醠ico
Feminino
Fluordesoxiglucose F18
Seres Humanos
Estudos Longitudinais
Imagem por Resson鈔cia Magn閠ica/m閠odos
Imagem Multimodal/m閠odos
Vias Neurais/diagn髎tico por imagem
Vias Neurais/fisiopatologia
Tomografia por Emiss鉶 de P髎itrons/m閠odos
Compostos Radiofarmac陁ticos
Descanso
Adulto Jovem
[Pt] Tipo de publica玢o:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de subst鈔cia:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] M阺 de entrada:1704
[Cu] Atualiza玢o por classe:170928
[Lr] Data 鷏tima revis鉶:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.1007/s00415-016-8389-4


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[PMID]:28017210
[Au] Autor:Necp醠 J; Skorvanek M
[Ad] Endere鏾:Dept. of Neurology, Zvolen Hospital, Zvolen, Slovakia.
[Ti] T韙ulo:Opsoclonus-myoclonus ataxia syndrome secondary to venlafaxine intoxication.
[So] Source:J Neurol Sci;372:19-20, 2017 Jan 15.
[Is] ISSN:1878-5883
[Cp] Pa韘 de publica玢o:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH prim醨io: Antidepressivos de Segunda Gera玢o/efeitos adversos
Ataxia/induzido quimicamente
S韓drome de Opsoclonia-Mioclonia/induzido quimicamente
Cloridrato de Venlafaxina/efeitos adversos
[Mh] Termos MeSH secund醨io: Adulto
Ataxia/complica珲es
Depress鉶/complica珲es
Depress鉶/tratamento farmacol骻ico
Feminino
Seres Humanos
S韓drome de Opsoclonia-Mioclonia/complica珲es
Transtornos de Estresse P髎-Traum醫icos/complica珲es
Transtornos de Estresse P髎-Traum醫icos/tratamento farmacol骻ico
[Pt] Tipo de publica玢o:CASE REPORTS; LETTER; VIDEO-AUDIO MEDIA
[Nm] Nome de subst鈔cia:
0 (Antidepressive Agents, Second-Generation); 7D7RX5A8MO (Venlafaxine Hydrochloride)
[Em] M阺 de entrada:1705
[Cu] Atualiza玢o por classe:170817
[Lr] Data 鷏tima revis鉶:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


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[PMID]:27730631
[Au] Autor:Gallerini S; Marsili L
[Ad] Endere鏾:Unit of Neurology, Misericordia Hospital, Grosseto, Italy.
[Ti] T韙ulo:Pediatric opsoclonus-myoclonus syndrome: the role of functional brain connectivity studies.
[So] Source:Dev Med Child Neurol;59(1):14-15, 2017 01.
[Is] ISSN:1469-8749
[Cp] Pa韘 de publica玢o:England
[La] Idioma:eng
[Mh] Termos MeSH prim醨io: Enc閒alo
S韓drome de Opsoclonia-Mioclonia
[Mh] Termos MeSH secund醨io: Crian鏰
Seres Humanos
Mioclonia
[Pt] Tipo de publica玢o:JOURNAL ARTICLE; COMMENT
[Em] M阺 de entrada:1710
[Cu] Atualiza玢o por classe:171019
[Lr] Data 鷏tima revis鉶:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE
[do] DOI:10.1111/dmcn.13296


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[PMID]:27658927
[Au] Autor:Chekroud AM; Anand G; Yong J; Pike M; Bridge H
[Ad] Endere鏾:FMRIB Centre, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
[Ti] T韙ulo:Altered functional brain connectivity in children and young people with opsoclonus-myoclonus syndrome.
[So] Source:Dev Med Child Neurol;59(1):98-104, 2017 Jan.
[Is] ISSN:1469-8749
[Cp] Pa韘 de publica玢o:England
[La] Idioma:eng
[Ab] Resumo:AIM: Opsoclonus-myoclonus syndrome (OMS) is a rare, poorly understood condition that can result in long-term cognitive, behavioural, and motor sequelae. Several studies have investigated structural brain changes associated with this condition, but little is known about changes in function. This study aimed to investigate changes in brain functional connectivity in patients with OMS. METHOD: Seven patients with OMS and 10 age-matched comparison participants underwent 3T magnetic resonance imaging (MRI) to acquire resting-state functional MRI data (whole-brain echo-planar images; 2mm isotropic voxels; multiband factor 2) for a cross-sectional study. A seed-based analysis identified brain regions in which signal changes over time correlated with the cerebellum. Model-free analysis was used to determine brain networks showing altered connectivity. RESULTS: In patients with OMS, the motor cortex showed significantly reduced connectivity, and the occipito-parietal region significantly increased connectivity with the cerebellum relative to the comparison group. A model-free analysis also showed extensive connectivity within a visual network, including the cerebellum and basal ganglia, not present in the comparison group. No other networks showed any differences between groups. INTERPRETATION: Patients with OMS showed reduced connectivity between the cerebellum and motor cortex, but increased connectivity with occipito-parietal regions. This pattern of change supports widespread brain involvement in OMS.
[Mh] Termos MeSH prim醨io: Enc閒alo/diagn髎tico por imagem
Vias Neurais/diagn髎tico por imagem
S韓drome de Opsoclonia-Mioclonia/diagn髎tico por imagem
S韓drome de Opsoclonia-Mioclonia/patologia
[Mh] Termos MeSH secund醨io: Adolescente
Enc閒alo/patologia
Mapeamento Encef醠ico
Estudos de Casos e Controles
Crian鏰
Estudos Transversais
Feminino
Seres Humanos
Processamento de Imagem Assistida por Computador
Imagem por Resson鈔cia Magn閠ica
Masculino
An醠ise de Componente Principal
Adulto Jovem
[Pt] Tipo de publica玢o:JOURNAL ARTICLE
[Em] M阺 de entrada:1704
[Cu] Atualiza玢o por classe:171018
[Lr] Data 鷏tima revis鉶:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE
[do] DOI:10.1111/dmcn.13262


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[PMID]:27958213
[Au] Autor:Bose K; Saha S; Islam MR; Chakraborty C; Laskar M
[Ad] Endere鏾:Department of Pediatrics, Chittaranjan Seva Sadan, Kolkata, West Bengal, India.
[Ti] T韙ulo:Opsoclonus myoclonus ataxia syndrome due to falciparum malaria in two Indian children.
[So] Source:Indian J Ophthalmol;64(11):852-854, 2016 Nov.
[Is] ISSN:1998-3689
[Cp] Pa韘 de publica玢o:India
[La] Idioma:eng
[Ab] Resumo:Opsoclonus-myoclonus ataxia (OMA) syndrome is rare in children, mostly caused by neuroblastoma. Here, we present two very rare cases presenting with OMA due to falciparum malaria. Both of them responded to a high dose of adrenocorticotrophin hormone and intravenous immunoglobulin without recurrence and complication.
[Mh] Termos MeSH prim醨io: Mal醨ia Falciparum/complica珲es
S韓drome de Opsoclonia-Mioclonia/etiologia
[Mh] Termos MeSH secund醨io: Animais
Ant韌enos de Protozo醨ios/an醠ise
Enc閒alo/patologia
Crian鏰
Seres Humanos
Imagem por Resson鈔cia Magn閠ica
Mal醨ia Falciparum/diagn髎tico
Mal醨ia Falciparum/parasitologia
Masculino
S韓drome de Opsoclonia-Mioclonia/diagn髎tico
Plasmodium falciparum/imunologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publica玢o:CASE REPORTS; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de subst鈔cia:
0 (Antigens, Protozoan)
[Em] M阺 de entrada:1708
[Cu] Atualiza玢o por classe:170817
[Lr] Data 鷏tima revis鉶:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.4103/0301-4738.195611


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[PMID]:27801769
[Au] Autor:Galli JR; Clardy SL; Paz Sold醤 MM
[Ad] Endere鏾:Department of Neurology, University of Utah, Salt Lake City, UT.
[Ti] T韙ulo:Adult-onset Opsoclonus-Myoclonus Syndrome Associated With Ganglionic Acetylcholine Receptor Autoantibody.
[So] Source:Neurologist;21(6):99-100, 2016 Nov.
[Is] ISSN:2331-2637
[Cp] Pa韘 de publica玢o:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Opsoclonus-myoclonus syndrome (OMS) may have a toxin induced, parainfectious, or paraneoplastic etiology. Several autoantibodies have been associated with adult-onset OMS, most commonly antineuronal nuclear antibody 2 (Ri), and it is most frequently associated with breast or small cell lung cancer. The nicotinic ganglionic acetylcholine receptor autoantibody (α3-AChR Ab) has not been described in association. CASE REPORT: A 46-year-old woman was evaluated for symptoms of oscillopsia, tremor, gait imbalance, and mild cognitive deficits that began 6 weeks prior. Neurological examination demonstrated opsoclonus, myoclonus, and mild gait ataxia. Laboratory evaluation revealed an elevated α3-AChR Ab at 0.27 nmol/L (normal ≤0.02 nmol/L) with no other autoantibodies or infectious etiology detected. Thorough screening revealed no evidence of associated malignancy. Immunotherapy with weekly methylprednisolone led to significant improvement. CONCLUSIONS: This first reported case of α3-AChR Ab positivity in the setting of adult-onset OMS expands the spectrum of associated autoantibodies. The mechanism of disease may be linked to cholinergic nuclei within the brainstem. This case suggests including α3-AChR Ab in the evaluation of adult-onset OMS, and highlights the importance of further understanding α3-AChR within the brain.
[Mh] Termos MeSH prim醨io: Autoanticorpos/imunologia
S韓drome de Opsoclonia-Mioclonia/imunologia
Receptores Nicot韓icos/imunologia
[Mh] Termos MeSH secund醨io: Idade de In韈io
Anticorpos Antinucleares/imunologia
Feminino
Glucocorticoides/uso terap陁tico
Seres Humanos
Metilprednisolona/uso terap陁tico
Meia-Idade
S韓drome de Opsoclonia-Mioclonia/tratamento farmacol骻ico
[Pt] Tipo de publica玢o:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de subst鈔cia:
0 (Antibodies, Antinuclear); 0 (Autoantibodies); 0 (Glucocorticoids); 0 (Receptors, Nicotinic); 0 (nicotinic receptor subunit alpha3); X4W7ZR7023 (Methylprednisolone)
[Em] M阺 de entrada:1702
[Cu] Atualiza玢o por classe:170817
[Lr] Data 鷏tima revis鉶:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE


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[PMID]:27397082
[Au] Autor:Torres-Vega E; Dur醤-Moreno M; S醤chez Del Pino M; Y狁ez Y; Ca馿te A; Castel V; L髉ez-Cuevas R; V韑chez JJ; Dalmau J; Graus F; Garc韆 Verdugo JM; Bataller L
[Ad] Endere鏾:Laboratorio de Neurolog韆, Instituto de Investigaci髇 Sanitaria La Fe, Hospital Universitario y Polit閏nico La Fe, CIBERER, Valencia, Spain.
[Ti] T韙ulo:Immunoproteomic studies on paediatric opsoclonus-myoclonus associated with neuroblastoma.
[So] Source:J Neuroimmunol;297:98-102, 2016 08 15.
[Is] ISSN:1872-8421
[Cp] Pa韘 de publica玢o:Netherlands
[La] Idioma:eng
[Ab] Resumo:We aimed to identify new cell-membrane antigens implicated in opsoclonus-myoclonus with neuroblastoma. The sera of 3 out of 14 patients showed IgG electron-microscopy immunogold reactivity on SH-SY5Y neuroblastoma cells. Immunoprecipitation experiments using rat brain synaptosomes and SH-SY5Y cells led to the identification of: (1) thirty-one nuclear/cytoplasmic proteins (including antigens HuB, HuC); (2) seven neuronal membrane proteins, including the Shaw-potassium channel Kv3.3 (KCNC3), whose genetic disruption in mice causes ataxia and generalized muscle twitching. Although cell-based assays did not demonstrate direct antigenicity, our findings point to Shaw-related subfamily of the potassium voltage-gated channels complexed proteins as hypothetical antigenic targets.
[Mh] Termos MeSH prim醨io: Neoplasias Encef醠icas
Sistema Nervoso Central/metabolismo
Neuroblastoma
S韓drome de Opsoclonia-Mioclonia
[Mh] Termos MeSH secund醨io: Animais
Neoplasias Encef醠icas/complica珲es
Neoplasias Encef醠icas/imunologia
Neoplasias Encef醠icas/patologia
Mol閏ulas de Ades鉶 Celular Neuronais/metabolismo
Linhagem Celular Tumoral
Sistema Nervoso Central/ultraestrutura
Crian鏰
Bases de Dados Factuais/estat韘tica & dados num閞icos
Encefalite/complica珲es
Encefalite/imunologia
Feminino
C閘ulas HEK293
Seres Humanos
Masculino
Prote韓as de Membrana/metabolismo
Prote韓as do Tecido Nervoso/metabolismo
Prote韓as do Tecido Nervoso/ultraestrutura
Neuroblastoma/complica珲es
Neuroblastoma/imunologia
Neuroblastoma/patologia
Prote韓as Nucleares/metabolismo
Prote韓as Nucleares/ultraestrutura
S韓drome de Opsoclonia-Mioclonia/complica珲es
S韓drome de Opsoclonia-Mioclonia/imunologia
S韓drome de Opsoclonia-Mioclonia/patologia
Ratos
Ratos Wistar
Canais de Pot醩sio Shaw/imunologia
Canais de Pot醩sio Shaw/metabolismo
Canais de Pot醩sio Shaw/ultraestrutura
Sinaptossomos/metabolismo
Sinaptossomos/ultraestrutura
Timoma/complica珲es
[Pt] Tipo de publica玢o:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de subst鈔cia:
0 (Cell Adhesion Molecules, Neuronal); 0 (IgLON5 protein, human); 0 (Membrane Proteins); 0 (Nerve Tissue Proteins); 0 (Nuclear Proteins); 0 (Shaw Potassium Channels)
[Em] M阺 de entrada:1708
[Cu] Atualiza玢o por classe:171121
[Lr] Data 鷏tima revis鉶:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160712
[St] Status:MEDLINE



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