Base de dados : MEDLINE Pesquisa : Tetrapleura [Palavras] Referências encontradas : 28 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 23175895 [Au] Autor: Odesanmi OS; Lawal RA; Ojokuku SA [Ad] Endereço: Department of Biochemistry, College of Medicine, University of Lagos, Nigeria. loladot2001@yahoo.com [Ti] Título: Effects of ethanolic extract of Tetrapleura tetraptera fruit on serum lipid profile and kidney function in male Dutch-white rabbits. [So] Source: Nig Q J Hosp Med;21(4):299-302, 2011 Oct-Dec. [Is] ISSN: 0189-2657 [Cp] País de publicação: Nigeria [La] Idioma: eng [Ab] Resumo: BACKGROUND: Tetrapleura tetraptera fruit is widely used in Nigeria as a spice and for treatment of various medical ailments. Reports indicate that feeding of extracts to animals produced some toxic effects and pathological lesions in some organs. OBJECTIVE: This study was designed to investigate the effects of 10 days oral administration of the ethanolic extract of Tetrapleura tetraptera (TTE) on the lipid profile and kidney function in male rabbits. METHODS: Twenty healthy, acclimatized male rabbits weighing 1.4 - 1.6 kg were randomly divided into four groups. Group 1 served as control and received only water while groups 2, 3 and 4 were administered 50, 100 and 150 mg/kg bodyweight of TTE respectively. Fasting serum from all groups were analyzed for lipid profile and kidney function parameters using standard protocols. Data were analyzed using student's t-test and ANOVA. RESULTS: Tetrapleura tetraptera extract elicited reduction in serum triacylglycerols, elevation of LDL-cholesterol and alteration of kidney function parameters in male rabbits. CONCLUSION: Ethanolic extract of Tetrapleura tetraptera may predispose to hypertension and cardiovascular diseases. [Mh] Termos MeSH primário: Lipídeos/sangue Extratos Vegetais/farmacologia Tetrapleura [Mh] Termos MeSH secundário: Animais LDL-Colesterol/sangue Relação Dose-Resposta a Droga Eletrólitos/sangue Etanol Rim/efeitos de drogas Testes de Função Renal Masculino Extratos Vegetais/toxicidade Coelhos Triglicerídeos/sangue [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cholesterol, LDL); 0 (Electrolytes); 0 (Lipids); 0 (Plant Extracts); 0 (Triglycerides); 64-17-5 (Ethanol) [Em] Mês de entrada: 1212 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 121126 [St] Status: MEDLINE

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[PMID]: 22112366 [Au] Autor: Lekana-Douki JB; Oyegue Liabagui SL; Bongui JB; Zatra R; Lebibi J; Toure-Ndouo FS [Ad] Endereço: Unité de Parasitologie Médicale (UPARAM), Centre International de Recherches Médicales de Franceville (CIRMF) B,P, 769 Franceville, Gabon. lekana_jb@yahoo.fr. [Ti] Título: In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa. [So] Source: BMC Res Notes;4:506, 2011. [Is] ISSN: 1756-0500 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Malaria remains a major public health problem, especially in tropical and subtropical regions because of the emergence and widespread of antimalarial drug resistance. Traditional medicine represents one potential source of new treatments. Here, we investigated the in vitro antiplasmodial activity of bark extracts from two Fabaceae species (Tetrapleura tertaptera and Copaifera religiosa) traditionally used to treat malaria symptoms in Haut-Ogooué province, Gabon. FINDINGS: The antiplasmodial activity of dichloromethane and methanolic extracts was tested on P. falciparum strains FCB (chloroquine-resistant) and 3D7 (chloroquine-sensitive) and on fresh clinical isolates, using the DELI method. Host cell toxicity was analyzed on MRC-5 human diploid embryonic lung cells using the MTT test.The dichloromethane extracts of the two plants had interesting activity (IC50 between 8.5 ± 4.7 and 13.4 ± 3.6 µg/ml). The methanolic extract of Tetrapleura tetraptera was less active (IC50 around 30 µg/ml) and the methanolic extract of Copaifera religiosa was inactive. The selectivity index (toxicity/antiplasmodial activity) of the dichloromethane extract of Tetrapleura tetraptera was high (around 7), while the dichloromethane extract of Copaifera religiosa had the lowest selectivity (0.6). The mean IC50 values for field isolates were less than 1.5 µg/ml for dichloromethane extracts of both plants, while methanolic extracts of Tetrapleura tetraptera showed interesting activity (IC50 = 13.1 µg/ml). The methanolic extract of Copaifera religiosa was also inactive on field isolates. CONCLUSIONS: Dichloromethane extracts of Tetrapleura tetraptera and Copaifera religiosa, two plants used to treat malaria in Gabon, had interesting antiplasmodial activity in vitro. These data provide a scientific rationale for the traditional use of these plants against malaria symptoms. Bioactivity-guided phytochemical analyses are underway to identify the active compounds. [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1210 [Cu] Atualização por classe: 121109 [Lr] Data última revisão: 121109 [Da] Data de entrada para processamento: 111216 [St] Status: PubMed-not-MEDLINE [do] DOI: 10.1186/1756-0500-4-506

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[PMID]: 19370941 [Au] Autor: Aboaba SA; Ogunwande IA; Walker TM; Setzer WN; Oladosu IA; Ekundayo O [Ad] Endereço: Department of Chemistry, University of Ibadan, Ibadan, Nigeria. [Ti] Título: Essential oil composition, antibacterial activity and toxicity of the leaves of Tetrapleura tetraptera (Schum. & Thonn.) taubert from Nigeria. [So] Source: Nat Prod Commun;4(2):287-90, 2009 Feb. [Is] ISSN: 1934-578X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The composition of the essential oil of the leaves of Tetrapleura tetraptera (Schum. & Thonn.) Taubert. from Nigeria were analyzed by GC/MS. Forty-one compounds representing 89.5% of the essential oil were characterized. The essential oil was dominated by 1,8-cineole (19.4%), 6,10,14-trimethyl-2-pentadecanone (13.6%), phytol (9.1%), alpha-pinene (8.1%) and geranylacetone (6.7%). The oil exhibited moderate toxicity in the brine shrimp lethality assay (117.5 microg/mL), and displayed weak antibacterial activity against Bacillus subtilis. [Mh] Termos MeSH primário: Antibacterianos/farmacologia Óleos Voláteis/química Óleos Vegetais/química Tetrapleura/química [Mh] Termos MeSH secundário: Antibacterianos/química Bactérias/efeitos de drogas Nigéria Óleos Voláteis/farmacologia Óleos Voláteis/toxicidade Óleos Vegetais/farmacologia Óleos Vegetais/toxicidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Oils, Volatile); 0 (Plant Oils) [Em] Mês de entrada: 0906 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 090417 [St] Status: MEDLINE

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[PMID]: 19153973 [Au] Autor: Noté OP; Mitaine-Offer AC; Miyamoto T; Paululat T; Pegnyemb DE; Lacaille-Dubois MA [Ad] Endereço: Laboratoire de Pharmacognosie, UMIB, UPRES EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 bd. Jeanne D' Arc, BP 87900, 21079 Dijon cedex, France. [Ti] Título: Tetrapterosides A and B, two new oleanane-type saponins from Tetrapleura tetraptera. [So] Source: Magn Reson Chem;47(3):277-82, 2009 Mar. [Is] ISSN: 1097-458X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: From the stem bark of Tetrapleura tetraptera, two new oleanane-type saponins, tetrapteroside A 3-O-{6-O-[(2E,6S)-2,6-dimethyl-6-hydroxyocta-2,7-dienoyl]-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranosyl-(1 --> 3)-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl}-3,27-dihydroxyoleanolic acid (1), and tetrapteroside B 3-O-{ beta-D-glucopyranosyl-(1 --> 2)-6-O-[(E)-feruloyl]-beta-D-glucopyranosyl-(1 --> 3)-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl}-3,27-dihydroxyoleanolic acid (2), were isolated. Further extractions from the roots led to the isolation of four known oleanane-type saponins. Their structures were elucidated by the combination of mass spectrometry (MS), one and two-dimensional NMR experiments. [Mh] Termos MeSH primário: Saponinas/química Tetrapleura/química [Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética Estrutura Molecular Saponinas/isolamento & purificação [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Saponins); 0 (tetrapteroside A); 0 (tetrapteroside B) [Em] Mês de entrada: 0904 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 090204 [St] Status: MEDLINE [do] DOI: 10.1002/mrc.2381

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[PMID]: 17236733 [Au] Autor: Okokon JE; Udokpoh AE; Antia BS [Ad] Endereço: Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria. judeefiom@yahoo.com [Ti] Título: Antimalaria activity of ethanolic extract of Tetrapleura tetraptera fruit. [So] Source: J Ethnopharmacol;111(3):537-40, 2007 May 22. [Is] ISSN: 0378-8741 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: The in vivo antiplasmodial activity of the ethanol fruit extract of Tetrapleura tetraptera used as spice and in the treatment of various ailment in Niger Delta region of Nigeria was evaluated in Plasmodium berghei infected mice. Tetrapleura tetraptera (300-900 mg/kg day) exhibited significant (P < 0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg day. The fruit extract possesses significant (P < 0.05) antiplasmodial activity with may have contributed to the immune status of the Nigerians against malaria in addition to its nutritive value. [Mh] Termos MeSH primário: Antimaláricos/farmacologia Malária/quimioterapia Extratos Vegetais/farmacologia Plasmodium berghei/efeitos de drogas Tetrapleura [Mh] Termos MeSH secundário: Animais Antimaláricos/administração & dosagem Cloroquina/farmacologia Modelos Animais de Doenças Relação Dose-Resposta a Droga Feminino Frutas Dose Letal Mediana Malária/mortalidade Masculino Medicina Tradicional Africana Camundongos Fitoterapia Extratos Vegetais/administração & dosagem Taxa de Sobrevida Testes de Toxicidade Aguda [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antimalarials); 0 (Plant Extracts); 54-05-7 (Chloroquine) [Em] Mês de entrada: 0707 [Cu] Atualização por classe: 111117 [Lr] Data última revisão: 111117 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 070427 [St] Status: MEDLINE

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[PMID]: 20162069 [Au] Autor: Aladesanmi AJ [Ad] Endereço: Department of Pharmacognosy, Faculty of Pharmacy Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria. jaladesa@oauife.edu.ng [Ti] Título: Tetrapleura tetraptera: molluscicidal activity and chemical constituents. [So] Source: Afr J Tradit Complement Altern Med;4(1):23-36, 2006. [Is] ISSN: 0189-6016 [Cp] País de publicação: Nigeria [La] Idioma: eng [Ab] Resumo: Tetrapleura tetraptera (Schumach. And Thonn) Taub, Mimosaceae, commonly known as Aridan (fruit), A single stemmed, robust, perennial tree of about 30 m. It has a grey/brown, smooth/rough bark with glabrous yound branchlets. The flower is yellow/pink and racemes white the fruit has dark brown, four winged pods 12-25 x 3.5-6.5 cm. It is generally found in the lowland forest of tropical Africa. The fruit consists of a fleshy pulp with small, brownish-black seeds. The fruit possesses a fragrant, characteristically pungent aromatic odour, which is attributed to its insect repellent property. It is used as spices and aroma (exotic tropical scents) and fish poisoning. It is one of the molluscicidal medicinal plants of Nigeria, also useful in the management of convulsions, leprosy, inflammation and/or rheumatoid pains. The documented biological and-or pharmacological activities are found to be molluscicidal, cardio-vascular, neuromuscular, hypotensive, anti-convulsant, trypanocidal, hirudinicidal, schistosomiasis control, anti-ulcerative, ectoxicity, anti-inflammatory, hypoglycaemic, anti-microbial, emulsifying property, birth control, food value and the control of intestinal parasites. Activity-guided fractionation of the methanol extract of the fruits of T. tetraptera led to the isolation of a saponin glycoside with an oleanolic acid aglycone, a monodesmosidic diglycoside of the rare sapogenin 27-hydroxyolean-12 (13)-en-28-oic acid; echinocystic acid-3-0-sodium sulfate from the stembark, umbelliferone and ferulic acid from the leaves and branches respectively. Also isolated from the fruits were aridanin and three of its olean-12-en-28-oic acid derivatives. All the compounds isolated either from the fruits or other parts were found to exhibit strong molluscicidal properties against the schistosomiasis-transmitting snails Biomphalaria glabrata. [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1005 [Cu] Atualização por classe: 100930 [Lr] Data última revisão: 100930 [Da] Data de entrada para processamento: 100217 [St] Status: PubMed-not-MEDLINE

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[PMID]: 16372367 [Au] Autor: Ojewole JA [Ad] Endereço: Department of Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa. ojewolej@ukzn.ac.za [Ti] Título: Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice. [So] Source: Phytother Res;19(12):1023-9, 2005 Dec. [Is] ISSN: 0951-418X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Previous studies in our laboratories and elsewhere have shown that the fruit of Tetrapleura tetraptera (Taub) (family: Fabaceae) is widely used in African traditional medicine for the management and/or control of an array of human ailments, including schistosomiasis, asthma, epilepsy, hypertension and so on. The present study was designed to investigate the analgesic and anticonvulsant effects of Tetrapleura tetraptera (Taub) fruit aqueous extract (TTE) in mice. Morphine (MPN, 10 mg/kg i.p.), diclofenac (DIC, 100 mg/kg i.p.), phenobarbitone (20 mg/kg i.p.) and diazepam (0.5 mg/kg i.p.) were used, respectively, as reference analgesic and anticonvulsant agents for comparison. T. tetraptera fruit aqueous extract (TTE, 50-800 mg/kg i.p.) produced dose-dependent, significant (p < 0.05-0.001) analgesic effects against thermally and chemically induced pain in mice. Like the standard anticonvulsant agents (phenobarbitone and diazepam) used, T. tetraptera fruit aqueous extract (TTE, 50-800 mg/kg i.p.) significantly (p < 0.05-0.001) delayed the onset of, and antagonized, pentylenetetrazole (PTZ)-induced seizures. Aqueous extract of the fruit (TTE, 50-800 mg/kg i.p.) also profoundly antagonized picrotoxin (PCT)-induced seizures, but only partially and weakly antagonized bicuculline (BCL)-induced seizures. However, the results of this experimental animal study indicate that Tetrapleura tetraptera (Taub) fruit aqueous extract (TTE) possesses analgesic and anticonvulsant properties. These findings lend pharmacological support to the suggested folkloric uses of the plant's fruit in the management and/or control of painful, arthritic inflammatory conditions, as well as for the management and/or control of epilepsy and childhood convulsions in some tropical African countries. [Mh] Termos MeSH primário: Analgésicos/uso terapêutico Anticonvulsivantes/uso terapêutico Fitoterapia Convulsões/quimioterapia Tetrapleura [Mh] Termos MeSH secundário: Ácido Acético Animais Bicuculina Feminino Frutas Temperatura Alta Masculino Camundongos Camundongos Endogâmicos BALB C Dor/quimioterapia Dor/etiologia Pentilenotetrazol Picrotoxina Extratos Vegetais/uso terapêutico Convulsões/induzido quimicamente [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Analgesics); 0 (Anticonvulsants); 0 (Plant Extracts); 124-87-8 (Picrotoxin); 485-49-4 (Bicuculline); 54-95-5 (Pentylenetetrazole); 64-19-7 (Acetic Acid) [Em] Mês de entrada: 0603 [Cu] Atualização por classe: 081121 [Lr] Data última revisão: 081121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 051228 [St] Status: MEDLINE

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[PMID]: 15507333 [Au] Autor: Ojewole JA; Adewunmi CO [Ad] Endereço: Department of Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa. ojewolej@ukzn.ac.za [Ti] Título: Anti-inflammatory and hypoglycaemic effects of Tetrapleura tetraptera (Taub) [Fabaceae] fruit aqueous extract in rats. [So] Source: J Ethnopharmacol;95(2-3):177-82, 2004 Dec. [Is] ISSN: 0378-8741 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: The fruit of Tetrapleura tetraptera (Taub) [Fabaceae] is frequently used in Tropical African traditional medicine for the management and/or control of an array of human ailments, including arthritis and other inflammatory conditions, asthma, diabetes mellitus, hypertension, epilepsy, schistosomiasis, and so on. The present study was undertaken to examine the anti-inflammatory and hypoglycaemic effects of Tetrapleura tetraptera (Taub) fruit aqueous extract in rats. Fresh egg albumin-induced pedal oedema and streptozotocin (STZ)-induced diabetes mellitus were used as experimental test models of inflammation and diabetes. Diclofenac (DIC, 100mg/kg p.o.) and chlorpropamide (250 mg/kg p.o.) were employed as reference anti-inflammatory and hypoglycaemic agents, respectively, for comparison. Tetrapleura tetraptera (TTE, 50-800 mg/kg p.o.) produced dose-related, significant reductions (P < 0.05-0.001) of the fresh egg albumin-induced acute inflammation of the rat hind paw oedema. The plant extract (TTE, 50-800 mg/kg p.o.) also produced dose-dependent, significant reductions (P < 0.05-0.001) in the blood glucose concentrations of both fasted normal and fasted diabetic rats. The results of this experimental animal study indicate that T. tetraptera fruit aqueous extract possesses anti-inflammatory and hypoglycaemic properties. These findings lend pharmacological credence to the suggested folkloric uses of the plant's fruit in the management and/or control of arthritis and other inflammatory conditions, as well as in adult-onset, type-2 diabetes mellitus in some Yoruba-speaking communities of South-Western Nigeria. [Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico Frutas Hipoglicemiantes/uso terapêutico Tetrapleura [Mh] Termos MeSH secundário: Animais Anti-Inflamatórios não Esteroides/isolamento & purificação Diabetes Mellitus Experimental/sangue Diabetes Mellitus Experimental/quimioterapia Edema/quimioterapia Hipoglicemiantes/isolamento & purificação Masculino Extratos Vegetais/isolamento & purificação Extratos Vegetais/uso terapêutico Ratos Ratos Wistar Água [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 7732-18-5 (Water) [Em] Mês de entrada: 0502 [Cu] Atualização por classe: 061115 [Lr] Data última revisão: 061115 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 041027 [St] Status: MEDLINE

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[PMID]: 15302524 [Au] Autor: Neuwinger HD [Ad] Endereço: Hauptstrasse 190, D-68789 St. Leon-Rot, Germany. hdneuwinger@web.de [Ti] Título: Plants used for poison fishing in tropical Africa. [So] Source: Toxicon;44(4):417-30, 2004 Sep 15. [Is] ISSN: 0041-0101 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Fishing with the aid of poisonous plants was formerly very common in Africa. Today this easy and simple method of fishing is forbidden but still practised in remote areas. The poisonous ingredients are pounded and thrown into a pool or dammed sections of a small river. After a time which varies according to conditions the fish begin to rise to the surface of the water and can readily be taken by hand. In general, the fish can be eaten without problems. 325 fish-poisoning plants, spread among 71 plant families with 183 genera, are presented. The closely related groups of Caesalpiniaceae, Mimosaceae and Papilionaceae clearly dominate. It is also remarkable that a great proportion are Euphorbiaceae. The plants most used are Tephrosia vogelii, Mundulea sericea, Euphorbia tirucalli, Gnidia kraussiana, Adenia lobat, Balanites aegyptiaca, Swartzia madagascariensis, Neoratanenia mitis, Tetrapleura tetraptera and Strychnos aculeata. Many fishing poisons play an important part in the preparation of arrow poisons and in traditional medicine. [Mh] Termos MeSH primário: Pesqueiros/métodos Peixes/metabolismo Plantas Tóxicas/envenenamento Venenos/química [Mh] Termos MeSH secundário: África Animais Clima Tropical [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Poisons) [Em] Mês de entrada: 0411 [Cu] Atualização por classe: 051116 [Lr] Data última revisão: 051116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 040810 [St] Status: MEDLINE

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[PMID]: 21214460 [Au] Autor: Olagunju JA; Oyedapo OO; Onasanya BA; Osoba OO; Adebanjo OO; Eweje O; Shodeinde AB [Ti] Título: Effects of isosaline extracts of tetrapleura tetrapetra and olax subscorpioides on certain biochemical parameters of albino rats. [So] Source: Pharm Biol;38(3):187-91, 2000. [Is] ISSN: 1388-0209 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The effects of isosaline extracts of Tetrapleura tetrapetra and Olax subscorpioides were investigated in albino rats. The treatment of rats with these extracts resulted in an increase in the activities of serum alanine aminotransferase, liver aspartate aminotransferase, alanine aminotransferase, acid phosphatase and alkaline phosphatase. The extract of Tetrapleura tetrapetra caused a significant increase in blood glucose and liver glycogen levels while the extract of Olax subscorpioides caused a slight reduction but not statistically significant in the levels of blood glucose and liver glycogen. Both extracts exhibited a significant reduction of protein in the livers of treated rats. [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1210 [Da] Data de entrada para processamento: 110110 [St] Status: PubMed-not-MEDLINE [do] DOI: 10.1076/1388-0209(200007)3831-SFT187

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