Base de dados : MEDLINE
Pesquisa : Vernonia [Palavras]
Referências encontradas : 456 [refinar]
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[PMID]:29309538
[Au] Autor:Chen BM; Su JQ; Liao HX; Peng SL
[Ad] Endereço:State Key Laboratory of Biocontrol, Sun Yat-Sen University, Guangzhou, China.
[Ti] Título:A greater foraging scale, not a higher foraging precision, may facilitate invasion by exotic plants in nutrient-heterogeneous conditions.
[So] Source:Ann Bot;121(3):561-569, 2018 Mar 05.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background and Aims: Soil nutrient heterogeneity has been proposed to influence competitive outcomes among different plant species. Thus, it is crucial to understand the effects of environmental heterogeneity on competition between exotic invasive and native species. However, the effects of soil nutrient heterogeneity on the competition between invasive and native plants have rarely been linked to root foraging behaviour. Methods: In this study, a competition experiment was performed with two invasive-native species pairs (BP-VC, Bidens pilosa vs. Vernonia cinerea; MM-PS, Mikania micrantha vs. Paederia scandens) grown under homogeneous and heterogeneous conditions in a common greenhouse environment. Root activity was assessed by determining the amount of strontium (Sr) taken up by the shoot of each species. Key Results: The invasive species exhibited a greater foraging scale, whereas the native species exhibited a higher foraging precision. A trade-off between foraging scale and precision was observed within each pair of invasive-native species. Compared with soil homogeneity, soil heterogeneity significantly increased the biomass of the two invasive species, B. pilosa and M. micrantha, under competitive conditions. Within each pair, the invasive species exhibited greater relative competitive ability with respect to shoot mass, and considerably more Sr taken up by the invasive species compared with the native species. The Sr acquisition results indicate that nutrient-poor conditions may facilitate the competitive ability of the native species V. cinerea, whereas M. micrantha may possess a stronger competitive ability regardless of soil nutrient conditions. Conclusion: Soil nutrient heterogeneity has the potential to promote the invasion of these two exotic species due to their larger foraging scale, stronger competitive ability and greater root activity relative to their counterpart native species. The present work highlights the importance of soil heterogeneity in plant invasion, particularly with regards to root foraging traits and competition between invasive and native plants.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[St] Status:In-Data-Review
[do] DOI:10.1093/aob/mcx172


  2 / 456 MEDLINE  
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[PMID]:29510543
[Au] Autor:Wang J; Song H; Wu X; Zhang S; Gao X; Li F; Zhu X; Chen Q
[Ad] Endereço:Department of Pharmacy, School of Pharmaceutical Science, Xiamen University, Xiamen 361102, China. diaoli187@163.com.
[Ti] Título:Steroidal Saponins from Vernonia amygdalina Del. and Their Biological Activity.
[So] Source:Molecules;23(3), 2018 Mar 05.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In the present study, four new steroidal saponins, namely vernoniamyoside A-D ( - ), together with the two known steroidal saponins vernoamyoside D ( ) and vernonioside B2 ( ) were isolated from the ethanol extract of leaves of the African medicinal plant Del. (Asteraceae). Their structures were demonstrated by spectral analyses along with 1D and 2D nuclear magnetic resonance (NMR) techniques and mass spectrometry (MS). The cytotoxicity of the compounds was also tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method on the cell lines Hela, MCF-7, BT-549 and MDA-MB-231. Vernoniamyoside A, vernoniamyoside B, and vernonioside B2 showed cytotoxicity towards BT-549 cell lines. Vernoniamyoside C, vernoniamyoside D and vernoamyoside D showed different levels of cytotoxic activities.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[St] Status:In-Process


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[PMID]:29391002
[Au] Autor:Kahaliw W; Hellman B; Engidawork E
[Ad] Endereço:Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, P. O. Box: 196, Gondar, Ethiopia. wubayehu.kahaliw@uog.edu.et.
[Ti] Título:Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells.
[So] Source:BMC Complement Altern Med;18(1):45, 2018 Feb 01.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Most of herbal medicines are used without any standard safety and toxicological trials although common assumption is that these products are nontoxic. However, this assumption is incorrect and dangerous, so toxicological studies should be done for herbal drugs. Although Pterolobium stellatum, Otostegia integrifolia and Vernonia amygdalina root extracts are frequently used in Ethiopian traditional medicine, there are no evidences of their active toxic compounds. Therefore, we made an effort to assess probable genotoxic effect of these plant extracts on DNA of human hematoma (HepG ) cells using alkaline comet assay. METHODS: Genotoxic effects of extracts were evaluated using single cell gel electrophoresis (SCGE) method on HepG cell. Regarding comet data, the average mean tail intensities (TI) from each individual experiment and treatment (usually at least 3 cultures/treatment) were pooled and the average mean TI was used as an indicator of DNA damage and the standard error of mean (SEM) as the measure of variance. RESULTS: DNA damage in the form of comet tail has been observed for 1 and 0.5 mg/ml P. stellatum chloroform and 80% methanol extracts on HepG cells, respectively. The chloroform extract of P. stellatum showed increased tail DNA percentage in a concentration dependent manner. Comet tail length in the chloroform P. stellatum extract treated cells (1 mg/ml) was significantly higher by 89% (p < 0.05) compared to vehicle treated controls. The rest of test extracts seemed to be without genotoxic effect up to a concentration of 0.5 mg/ml. CONCLUSIONS: Our findings show that two extracts from one plant evaluated have a genotoxic potential in vitro which calls for a more thorough safety evaluation. Such evaluation should include other end-points of genotoxicity apart from DNA damage, and possibly also pure compounds.
[Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos
Mutagênicos/toxicidade
Extratos Vegetais/toxicidade
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Ensaio Cometa
Fabaceae/química
Células Hep G2
Seres Humanos
Lamiaceae/química
Testes de Mutagenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mutagens); 0 (Plant Extracts)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2056-x


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[PMID]:29241322
[Au] Autor:Ekeleme-Egedigwe CA; Ijeh II; Okafor PN
[Ad] Endereço:Department of Chemistry/Biochemistry, Federal University Ndufu Alike Ikwo, Nigeria.
[Ti] Título:Modulatory effects of dietary supplementation by Vernonia amygdalina on high-fat-diet-induced obesity in Wistar rats.
[So] Source:Acta Sci Pol Technol Aliment;16(4):431-442, 2017 Oct-Dec.
[Is] ISSN:1898-9594
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Obesity is a growing public health problem arising from energy imbalance. The effect of 10% dietary incorporation of Vernonia amygdalina (VA) leaves into high-fat diets on some biological markers of adiposity and dyslipidaemia was investigated. METHODS: Experimental diets consisted of the following – CD (control diet); HFD (high-fat diet); and HFD- VA (HFD containing 10% Vernonia amygdalina leaves) supplementation. Fifteen male Wistar rats were randomly divided into three groups of five animals each. After twelve weeks of feeding, serum lipid profile, blood glucose concentrations, body weight, adiposity index, feed intake, fecal loss and relative organ weight were investigated. RESULTS: Vernonia amygdalina (VA) inhibited HFD-induced weight gain and adiposity in rats. HFD-induced obese rats showed a significant increase in the levels of serum TG and TC compared to rats on a normal diet. However, the levels of serum TG, TC, LDL-C in HFDVA rats reduced significantly relative to the levels in HFD rats. Our results indicate that HFDVA reversed fatty infiltration leading to decreased body weight and fat tissue mass in the rats. CONCLUSIONS: These results suggested that incorporation of Vernonia amygdalina into high-fat diets may have therapeutic potentials for obesity and related metabolic disorders. Further studies to explore its possibility as an alternative pharmacologic agent to treat obesity are warranted.
[Mh] Termos MeSH primário: Dieta Hiperlipídica/efeitos adversos
Gorduras na Dieta/administração & dosagem
Obesidade/etiologia
Vernonia/química
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Gorduras na Dieta/efeitos adversos
Suplementos Nutricionais
Masculino
Obesidade/tratamento farmacológico
Extratos Vegetais/farmacologia
Folhas de Planta
Distribuição Aleatória
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Plant Extracts)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.17306/J.AFS.0504


  5 / 456 MEDLINE  
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[PMID]:29382040
[Au] Autor:Kimani NM; Matasyoh JC; Kaiser M; Brun R; Schmidt TJ
[Ad] Endereço:Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus Corrensstraße 48, D-48149 Münster, Germany. m_kima01@uni-muenster.de.
[Ti] Título:Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity.
[So] Source:Molecules;23(2), 2018 Jan 27.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In the endeavor to obtain new antitrypanosomal agents, particularly sesquiterpene lactones, from Kenyan plants of the family Asteraceae, Sch. Bip. was investigated. Bioactivity-guided fractionation and isolation in conjunction with LC/MS-based dereplication has led to the identification of vernodalol ( ) and isolation of vernodalin ( ), 11ß,13-dihydrovernodalin ( ), 11ß,13-dihydrovernolide ( ), vernolide ( ), 11ß,13-dihydrohydroxyvernolide ( ), hydroxyvernolide ( ), and a new germacrolide type sesquiterpene lactone vernocinerascolide ( ) from the dichloromethane extract of leaves. Compounds - were characterized by extensive analysis of their 1D and 2D NMR spectroscopic and HR/MS spectrometric data. All the compounds were evaluated for their in vitro biological activity against bloodstream forms of and for cytotoxicity against the mammalian cell line L6. Vernodalin ( ) was the most active compound with an IC value of 0.16 µM and a selectivity index of 35. Its closely related congener 11ß,13-dihydrovernodalin ( ) registered an IC value of 1.1 µM and a selectivity index of 4.2.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[St] Status:In-Process


  6 / 456 MEDLINE  
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[PMID]:29145845
[Au] Autor:Wang JY; Chen H; Wang YY; Wang XQ; Chen HY; Zhang M; Tang Y; Zhang B
[Ad] Endereço:Pharmacology department, School of Pharmacy, Shihezi University, Shihezi, 832002, China.
[Ti] Título:Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes.
[So] Source:BMC Syst Biol;11(1):103, 2017 Nov 16.
[Is] ISSN:1752-0509
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vitiligo is a long-term skin disease characterized by the loss of pigment in the skin. The current therapeutic approaches are limited. Although the anti-vitiligo mechanisms of Vernonia anthelmintica (L.) remain ambiguous, the herb has been broadly used in Uyghur hospitals to treat vitiligo. The overall objective of the present study aims to identify the potential lead compounds from Vernonia anthelmintica (L.) in the treatment of vitiligo via an oral route as well as the melanogenic mechanisms in the systematic approaches in silico of admetSAR and substructure-drug-target network-based inference (SDTNBI). RESULTS: The results showed that the top 5 active compounds with a relatively higher bioavailability that interacted with 23 therapeutic targets were identified in Vernonia anthelmintica (L.) using admetSAR and SDTNBI methods. Among these compounds, Isorhamnetin and Kaempferide, which are methyl-flavonoids, performed 1st and 2nd. Isorhamnetin and Kaempferide significantly increased the expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT) and the tyrosinase activity in B16F10 cells. Isorhamnetin and Kaempferide significantly increased the mRNA-expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT), the protein level of MITF and the tyrosinase activity. Based on the SDTNBI method and experimental verification, Isorhamnetin and Kaempferide effectively increased melanogenesis by targeting the MC1R-MITF signaling pathway, MAPK signaling pathway, PPAR signaling pathway (PPARA, PPARD, PPARG), arachidonic acid metabolism pathway (ALOX12, ALOX15, CBR1) and serotonergic synapses (ALOX12, ALOX15) in the treatment of vitiligo from a network perspective. CONCLUSION: We identified the melanogenic activity of the methyl-flavonoids Isorhamnetin and Kaempferide, which were successfully predicted in a network pharmacological analysis of Vernonia anthelmintica (L.) by admetSAR and SDTNBI methods.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[St] Status:In-Process
[do] DOI:10.1186/s12918-017-0486-1


  7 / 456 MEDLINE  
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Barros, Cláudio S L
Texto completo
[PMID]:29128544
[Au] Autor:Godoy KCS; Leal PV; Araújo MA; Souza AI; Pott A; Lee ST; Barros CSL; de Lemos RAA
[Ad] Endereço:Programa de Pós-graduação Em Ciências Veterinárias, Faculdade de Medicina Veterinária e Zootecnia (FAMEZ), Universidade Federal de Mato Grosso Do Sul (UFMS), Av. Senador Felinto Muller, 2443, 79070-900 Campo Grande, MS, Brazil. Electronic address: k.c.s.godoy@gmail.com.
[Ti] Título:Experimental poisoning by Vernonia rubricaulis in sheep.
[So] Source:Toxicon;141:9-14, 2017 Nov 08.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In order to evaluate the susceptibility of sheep to V. rubricaulis and to establish the clinical signs, serum biochemistry, and pathological findings, eight sheep were fed varying doses of V. rubricaulis. The onset of clinical signs occurred 6-48 h after the ingestion of V. rubricaulis. Clinical courses lasted 6-56 h after the ingestion of the plant. Serum activities of aspartate aminotransferase, gamma-glutamyl transferase, and alkaline phosphatase were highly elevated and glucose blood levels were low in affected sheep. Clinical signs consisted of apathy, anorexia, dry muzzle, respiratory distress, abdominal pain, and mushy feces with streaks of blood and mucus. Two sheep had neurological signs including muscle fasciculation, nystagmus, paddling movements, and blindness. Liver necrosis could be detected antemortem through liver biopsy. Five sheep died and three recovered. The liver was affected in all necropsied sheep; it increased in volume and had marked accentuation of the lobular pattern with red, depressed areas intercalated with a pale yellow network. Ascites and hydropericardium were consistent findings. Microscopically, centrilobular to massive coagulative necrosis was observed. Coagulative necrosis was also observed in a few proximal renal tubules. Microscopic lesions were not found in any other organs. The severity of liver lesions was proportional to the dose. Chemical analysis to detect carboxyatractyloside in V. rubricaulis plant material was negative. It is concluded that V. rubricaulis poisoning in sheep is clinically, biochemically, and pathologically characteristic of an acute hepatoxicosis.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[St] Status:Publisher


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[PMID]:29122539
[Au] Autor:Pollo LAE; Frederico MJ; Bortoluzzi AJ; Silva FRMB; Biavatti MW
[Ad] Endereço:Programa de Pós-Graduação em Farmácia, CCS, Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brazil.
[Ti] Título:A new polyacetylene glucoside from Vernonia scorpioides and its potential antihyperglycemic effect.
[So] Source:Chem Biol Interact;279:95-101, 2017 Nov 06.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Natural polyacetylene compounds have been found mainly in seven botanical families and remain underexplored and understudied, despite its inherent chemical and biological reactivity, due to the presence of conjugated triple bonds. Some polyacetylene glucosides have been found to stimulate glucose uptake in C5BL/ks-db/db obese diabetic mice, and since polyacetylene glucosides previously found in Vernonia scorpioides showed little to none cytotoxicity, in this study the antihyperglycemic potential of a new V. scorpioides polyacetylene glucoside has been accessed in order to shine a new light on the biological activity of this unique scaffold. For the isolation of this new compound an optimized method of Centrifugal Partition Chromatography (CPC) is for the first time described together with its X-ray data. The results demonstrate that 3,4-dihydrovernoniyne-4-O-ß-glucoside has significant effect on glycaemia at low dose 0.5 mg/kg, and pointing that the anti-hyperglycemic effect may be due in part to the inhibition of intestinal disaccharidases.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[St] Status:Publisher


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[PMID]:29102764
[Au] Autor:Suleman S; Beyene Tufa T; Kebebe D; Belew S; Mekonnen Y; Gashe F; Musa S; Wynendaele E; Duchateau L; De Spiegeleer B
[Ad] Endereço:Jimma University Laboratory of Drug Quality (JuLaDQ), Jimma University, PO Box 378, Jimma, Ethiopia; School of Pharmacy, Jimma University, P.O.Box 378, Jimma, Ethiopia. Electronic address: sultan.suleman@ju.edu.et.
[Ti] Título:Treatment of Malaria and Related Symptoms Using Traditional Herbal Medicine in Ethiopia.
[So] Source:J Ethnopharmacol;, 2017 Nov 01.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal plants have always been an integral part of different cultures in Ethiopia in the treatment of different illnesses including malaria and related symptoms. However, due to lack of proper documentation, urbanization, drought, acculturation and deforestation, there is an increased risk of losing this traditional knowledge. Hence, the use of the indigenous knowledge should be well documented and validated for potential future use. AIM OF THE STUDY: To gather and document information on medicinal plants which are used in the traditional treatment of malaria and related symptoms in Ethiopia. MATERIALS AND METHODS: First, an ethnomedicinal survey of plants was conducted in 17 districts of Jimma zone, the Oromia national regional state of Ethiopia. Jimma zone is malarious and rich in natural flora. A total of 115 traditional healers were interviewed using a semi-structured questionnaire containing personal data of the respondents, and information on medicinal plants used to treat malaria and related symptoms. In addition, a literature search using Medline/PubMed, Google Scholar, ScienceDirect and HINARI was conducted on the indigenous use, in-vitro/in-vivo anti-malarial activity reports, and the chemical characterization of medicinal plants of Ethiopia used against malaria. RESULTS: From ethnomedicinal survey, a total of 28 species of plants used in the traditional treatment of malaria and related symptoms in Jimma Zone were collected, identified and documented. In addition, the literature search revealed that 124 medicinal plant species were reported to be traditionally used in the treatment of malaria in Ethiopia. From both ethnomedicinal survey and the literature search, Asteraceae and Fabaceae were the most represented families and Allium sativum L., Carica papaya L., Vernonia amygdalina Del., Lepidium sativum L. and Croton macrostachyus Del. were the most frequently reported plant species for their anti-malarial use. The dominant plant parts used in the preparation of remedies were leaves. About 54% of the medicinal plants documented in the survey have been reported as an anti-malarial plant in the literature search. Furthermore, the in-vitro and in-vivo anti-plasmodial activity reports of extracts from some of plant species were found to support the traditional claim of the documented plants. Moreover, literatures indicate that several secondary metabolites isolated from certain plant species that are traditionally used for the treatment of malaria and related symptoms in Ethiopia demonstrate strong anti-plasmodial activity. CONCLUSIONS: The result of the current study showed that traditional knowledge is still playing an important role in the management of malaria and related symptoms in Ethiopia. Allium sativum L., Carica papaya L., Vernonia amygdalina Del., and Lepidium sativum L. are the most commonly reported species as anti-malarial plants and the traditional claim of some species was supported by known anti-plasmodial activity and bioactivity reports. The finding of this study is important in the rational prioritization of plant species which are potentially used for investigating new compounds, which could be efficacious for malaria treatment.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[St] Status:Publisher


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[PMID]:29050491
[Au] Autor:Akharaiyi FC; Akinyemi AJ; Isitua CC; Ogunmefun OT; Opakunle SO; Fasae JK
[Ti] Título:Some antidiabetic medicinal plants used by traditional healers in Ado Ekiti, Nigeria.
[So] Source:Bratisl Lek Listy;118(8):504-505, 2017.
[Is] ISSN:0006-9248
[Cp] País de publicação:Slovakia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The work described plants collection, preparation and administration for diabetes cure in Ado Ekiti in Nigeria. METHODS: Twenty three plant samples were identified for the use in the treatment of diabetes by the herbalists. The plants that are common among the healers are Anthocleista djalonensis, Vernonia amygdalina, Ocimum gratissimum, Momordica charantia. RESULTS: The most preferred method of preparation by the healers is concoction and decoction of fresh leaves, stem bark and roots. However, for emergency sake, some healers dried these plant parts, ground to smooth powder and packaged in brown bottles or in nylon which are either sold or given to people, but must be soaked in cold or warm water before use. CONCLUSION: The use of medicinal plants in healing diabetes is a common practice by traditional healers in Ado Ekiti and never treat their patients in conjunction with modern medicines (Ref. 4).
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[St] Status:In-Data-Review
[do] DOI:10.4149/BLL_2017_097



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