Base de dados : MEDLINE
Pesquisa : ajuga [Palavras]
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  1 / 197 MEDLINE  
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[PMID]:29468889
[Au] Autor:Mamadalieva NZ; Youssef FS; Ashour ML; Sasmakov SA; Tiezzi A; Azimova SS
[Ad] Endereço:a Institute of the Chemistry of Plant Substances of the Academy Sciences of Uzbekistan , Tashkent , Uzbekistan.
[Ti] Título:Chemical composition, antimicrobial and antioxidant activities of the essential oils of three Uzbek Lamiaceae species.
[So] Source:Nat Prod Res;:1-4, 2018 Feb 22.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The chemical composition of the essential oil from the aerial parts of three Lamiaceae species from Uzbekistan was investigated by GC-MS analysis. ß-Linalool (26.6%), α-terpineol (10.0%), coumarin (8.9%) and 4,5,7,7α-tetrahydro-4,4,7α-trimethyl-2(6H)-benzofuranone (5.4%) resulted as the main components of Ajuga turkestanica essential oil, while camphene (17.1%), 1,8-cineole (15.9%), ß-cymene (7.9%) and limonene (7.4%) in Phlomis regelii. The essential oil of Thymus seravschanicus was dominated by thymol (37.5%), phellandral (26.0%), τ-terpinene (6.6%) and ß-cymene (5.2%). The essential oils had considerable antimicrobial activity against different bacterial strains and fungi. Among the tested samples of essential oils, P. regelii essential oil has the significant antioxidant activity with IC value of 117.8 ± 8.02 µg/mL.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[St] Status:Publisher
[do] DOI:10.1080/14786419.2018.1443088


  2 / 197 MEDLINE  
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[PMID]:29109757
[Au] Autor:Sawada Y; Sugimoto A; Hananouchi T; Sato N; Nagaoka I
[Ad] Endereço:Technology Research and Development Laboratory, Research and Development Headquarters, Asahi Group Foods, Ltd., Moriya, Ibaraki 302-0106, Japan.
[Ti] Título:Evaluation of the efficacy of extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double-blind, placebo-controlled study.
[So] Source:Exp Ther Med;14(5):4561-4571, 2017 Nov.
[Is] ISSN:1792-0981
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:The aim of the present study was to assess the efficacy and safety of the oral administration of extract (ADE) supplement to individuals with knee discomfort associated with physical activity. A randomized, double-blind, placebo-controlled study was conducted using 48 subjects. The subjects were randomly allocated to an ADE diet group (oral administration of ADE-containing diet, n=24) or a placebo group (n=24), and the intervention was conducted for 12 weeks. A total of 22 subjects in the placebo group and 22 subjects in the ADE diet group were assessed to be eligible for assessment of the efficacy of supplement. Knee function was assessed by changes in the scores of the Japanese Knee Osteoarthritis Measure (JKOM) questionnaire and the scores of the Japan Orthopedic Association (JOA) criteria, as well as by analyzing the levels of type II collagen synthesis and degradation biomarkers (procollagen II C-terminal propeptide, cross-linked C-telopeptide of type II collagen, collagen type II cleavage and matrix metalloproteinase-13). Outcomes were measured at the baseline and at 4, 8 and 12 weeks from the start of administration. Subscale II (joint flexion/stiffness) of the JOA criteria was markedly improved in the ADE diet group compared with the placebo group at 8 and 12 weeks during the intervention. Furthermore, in the subgroup analyses using subjects with mild knee discomfort, subscale II (pain/stiffness) and IV (general activities) scores of JKOM were significantly improved (P<0.05) and total JKOM score was markedly improved in the ADE diet group compared with the placebo group at week 8 of the intervention. No adverse effects were identified for the administration of ADE. In conclusion, these observations suggest that the administration of an ADE-containing diet is safe and improves joint function (flexion and stiffness) and general activity in subjects with mild knee discomfort. Therefore, ADE could be a promising candidate as a functional food that is beneficial to joint health.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3892/etm.2017.5064


  3 / 197 MEDLINE  
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[PMID]:29031208
[Au] Autor:Wang JJ; Jin H; Zheng SL; Xia P; Cai Y; Ni XJ
[Ad] Endereço:Department of Transplantation, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, PR China.
[Ti] Título:Phytoecdysteroids from Ajuga iva act as potential antidiabetic agent against alloxan-induced diabetic male albino rats.
[So] Source:Biomed Pharmacother;96:480-488, 2017 Oct 11.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The present study investigated the protective effect of phytoecdysteroids extracted from the Ajuga iva plant on body weight changes, blood glucose, insulin total protein, blood urea nitrogen (BUN), creatinine, triglycerides (TG), cholesterol, lipid peroxidation, antioxidant enzymes, pancreatic histopathology and hexokinase-I expression in the alloxan-induced diabetic rats. Experimental diabetes was induced following 15day intraperitoneal administration of alloxan. The rats were divided into four groups. Group I served as a sham group, and group II served as the diabetic control. Group III served as a treatment for phytoecdysteroids (10mg/kg), and group IV served as a treatment for phytoecdysteroids (20mg/kg). Phytoecdysteroids restored body weight loss to its antihyperglycemic effect. Blood glucose was reduced 19.2 and 52.9% in group III and IV respectively. Blood insulin (54.9 and 105.88%) and total protein (25 and 72.2%) was increased in group III and IV respectively. BUN, creatinine, TG, cholesterol and lipid peroxidation was significantly reduced following treatment. Catalase, superoxide dismutase (SOD), and glutathione peroxidase activity were significantly increased following treatment. Islet ß-cells are lost in alloxan-induced diabetic rats. Regeneration of islets and reduced atrophy of acinar cells were noted. The number of insulin-secreting cells was tremendously reduced in alloxan-induced diabetic rats. Insulin-secreting cells were increased 48 and 61% in group III and IV respectively. Hexokinase-I mRNA (28.3 & 93.5%) and protein (27.9 and 55.3%) expression were significantly increased following treatment. Taking all these data together, it is suggested that the phytoecdysteroid could be a potential therapeutic agent against experimental diabetes.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[St] Status:Publisher


  4 / 197 MEDLINE  
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[PMID]:29026858
[Au] Autor:Khanavi M; Najafi B; Sadati SN; Abai MR; Vatandoost H
[Ad] Endereço:Department of Pharmacognosy and Persian Medicine and Pharmacy Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:Chemical Constitute and Larvicidal Activity of Fractions of Plant against Malaria Vector .
[So] Source:J Arthropod Borne Dis;11(1):116-123, 2017 Mar.
[Is] ISSN:2322-1984
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGRAND: The genus , belongs to Lamiaceae family, is one of the exclusive subspecies in the flora of Iran. The plants of this genus are used traditionally for treatment of joints pain, gout, jaundice, and as insecticide. METHODS: larvicidal activity of methanol 80% extract and partition fractions of hexane, chloroform, and ethyl acetate obtained from aerial parts of subspecies against malaria vector was evaluated. Phytochemical study of active fraction was analyzed using column chromatography and spectroscopy. RESULTS: According to the results, among different fractions, hexane fraction has the most larvicidal activity with mortality rate of 100% in concentration of 102 ppm and LC of 95.66ppm. The structure of compound 1, main phytoecdysteroid compound separated from hexane fraction, was determined to be ajugalide-E. CONCLUSION: The results suggested that the hexane fraction of subsp could be used as a natural and biodegradable insecticide.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[St] Status:PubMed-not-MEDLINE


  5 / 197 MEDLINE  
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[PMID]:28886077
[Au] Autor:Shaheen H; Qaseem MF; Amjad MS; Bruschi P
[Ad] Endereço:Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.
[Ti] Título:Exploration of ethno-medicinal knowledge among rural communities of Pearl Valley; Rawalakot, District Poonch Azad Jammu and Kashmir.
[So] Source:PLoS One;12(9):e0183956, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Medicinal plants are the basic source of health care in the Pearl Valley District Poonch, Azad Jammu, and Kashmir. The basic aim of present study was to record information about the use of plants in herbal preparation and quantification of recorded data. MATERIALS AND METHODS: The research was conducted with the null hypothesis that there was no differential distribution of knowledge among the communities between genders and among different age groups in the study area and across cultural medicinal uses of the plants are similar. To check these hypotheses information about medicinal plants was collected from 46 laypeople and 18 herbalists by using an open ended and semistructured questionnaire. Different ethnobotanical indices were calculated in order to quantify the knowledge on the medicinal plants reported in the study. RESULTS: Our study recorded 136 species of medicinal plants belonging to 45 families with Asteraceae (14 species) as the dominant family of the area. Decoction (26 species), juice and powder (24 species each) were most common methods of preparation. Spearman's correlation analysis showed that age and gender had the significant effect on both numbers of mentioned species and different uses. A number of known medicinal plants and the number of different uses (H: 38.51; p < 0.001) differ significantly as indicated by Kruskal-Wallis tests. These results showed that the knowledge about the plant varies among different age groups, which were the first hypothesis of the present study. The highest use values (UVs) were reported for Berberis lyceum and Ajuga bracteosa (1.13 each) followed by Abies pindrow (1.03). Highest informant consensus factor (ICF) values were recorded for digestive system diseases (ICF = 0.90) and muscular and skeletal system diseases (ICF = 0.89). The value of Jaccarad index ranged from 6.11 to 32.97 with an average value of 19.84, percentage of similarity was highest between study area and Pir Lasura National Park (34.62%). CONCLUSION: High similarity might be due to the fact that the communities living in these areas have same sociocultural values and have more opportunities to exchange their traditional knowledge. The present study provides practical evidence about the use of medicinal plants among the inhabitants of the Pearl Valley.
[Mh] Termos MeSH primário: Conhecimento
Medicina Tradicional
População Rural
[Mh] Termos MeSH secundário: Biodiversidade
Conservação dos Recursos Naturais
Feminino
Geografia
Seres Humanos
Masculino
Preparações de Plantas/isolamento & purificação
Preparações de Plantas/uso terapêutico
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183956


  6 / 197 MEDLINE  
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[PMID]:28874070
[Au] Autor:Chen T; Diao QY; Yu HZ; Jiao CL; Ruan J
[Ad] Endereço:a Yantai Center for Food and Drug Control and Test , Yantai , China.
[Ti] Título:Phytochemical, cytotoxic and chemotaxonomic study on Ajuga forrestii Diels (Labiatae).
[So] Source:Nat Prod Res;:1-5, 2017 Sep 06.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A phytochemical investigation of Ajuga forrestii Diels led to the isolation of 14 compounds, including eight neo-clerodane diterpenes (1-8), two phytoecdysteroids (9, 11), one stigmastane sterol (10) and three iridoid glycosides (12-14). The structures of these compounds were identified by spectroscopic methods and a comparison of their data with those reported in the literature. This is the first report of compounds 1-14 from A. forrestii. The cytotoxic activities of the aqueous extract of A. forrestii and several compounds have been studied and the chemotaxonomic significance of isolated compounds has also been summarised.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[St] Status:Publisher
[do] DOI:10.1080/14786419.2017.1371161


  7 / 197 MEDLINE  
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[PMID]:28870197
[Au] Autor:Zahra SS; Ahmed M; Qasim M; Gul B; Zia M; Mirza B; Haq IU
[Ad] Endereço:Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
[Ti] Título:Polarity based characterization of biologically active extracts of Ajuga bracteosa Wall. ex Benth. and RP-HPLC analysis.
[So] Source:BMC Complement Altern Med;17(1):443, 2017 Sep 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The concept of botanical therapeutics has revitalized due to wide importance of plant derived pharmaceuticals. Therefore, the ameliorative characteristics of Ajuga bracteosa were studied. METHODS: Total phenolic content, flavonoid content, antioxidant capacity, reducing power and free-radical scavenging activity were determined colorimetrically. Specific polyphenols were quantified by RP-HPLC analysis. Preliminary cytotoxicity was tested using brine shrimp lethality assay while antiproliferative activity against THP-1 and Hep-G2 cell lines was determined by MTT and SRB protocols respectively. Antileishmanial potential was assessed via MTT colorimetric method. To investigate antidiabetic prospect, α-amylase inhibition assay was adopted whereas disc diffusion method was used to detect likely protein kinase inhibitory, antibacterial and antifungal activities. RESULTS: Among fifteen different extracts, maximum total phenolic content (10.75 ± 0.70 µg GAE/mg DW), total reducing power (23.90 ± 0.70 µg AAE/mg DW) and total antioxidant capacity (11.30 ± 0.80 µg AAE/mg DW) were exhibited by methanol extract with superlative percent extract recovery (17.50 ± 0.80% w/w). Chloroform-methanol extract demonstrated maximum flavonoid content (4.10 ± 0.40 µg QE/mg DW) and ethanol extract exhibited greatest radical scavenging activity (IC 14.40 ± 0.20 µg/ml). RP-HPLC based quantification confirmed polyphenols such as pyrocatechol, gallic acid, resorcinol, catechin, chlorogenic acid, caffeic acid, syringic acid, p-coumaric acid, ferulic acid, vanillic acid, coumarin, sinapinic acid, trans-cinnamic acid, rutin, quercetin and kaempferol. The brine shrimp lethality assay ranked 78.60% extracts as cytotoxic (LC ≤ 250 µg/ml) whereas significant THP-1 inhibition was shown by methanol-acetone extract (IC 4.70 ± 0.43 µg/ml). The antiproliferative activity against Hep-G2 hepatoma cancer cell line was demonstrated by n-hexane, ethylacetate and methanol-distilled water (IC 8.65-8.95 µg/ml) extracts. Methanol extract displayed prominent protein kinase inhibitory activity (MIC 12.5 µg/disc) while n-hexane extract revealed remarkable antileishmanial activity (IC 4.69 ± 0.01 µg/ml). The antidiabetic potential was confirmed by n-hexane extract (44.70 ± 0.30% α-amylase inhibition at 200 µg/ml concentration) while a moderate antibacterial and antifungal activities were unveiled. CONCLUSION: The variation in biological spectrum resulted due to use of multiple solvent systems for extraction. We also deduce that the valuable information gathered can be utilized for discovery of anticancer, antileishmanial, antioxidant and antidiabetic bioactive lead candidates.
[Mh] Termos MeSH primário: Ajuga/química
Extratos Vegetais/análise
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/análise
Antioxidantes/farmacologia
Artemia
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Inibidores Enzimáticos/análise
Inibidores Enzimáticos/farmacologia
Flavonoides/análise
Flavonoides/farmacologia
Seres Humanos
Fenóis/análise
Fenóis/farmacologia
alfa-Amilases/antagonistas & inibidores
alfa-Amilases/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Enzyme Inhibitors); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1951-5


  8 / 197 MEDLINE  
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[PMID]:28791415
[Au] Autor:Nan L; Huang M; Lai W; Jia R; Zheng Y; Yang L; Xie Q; Peng W
[Ad] Endereço:College of Pharmacy, School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
[Ti] Título:Impacts of the serum containing total flavonoids of Ajuga on rat glomerular mesangial cells.
[So] Source:Mol Med Rep;16(4):4895-4902, 2017 Oct.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:The aim of the current study was to investigate the impacts and possible mechanisms of total flavonoids of Ajuga (TFA) on glomerular mesangial cells (GMC) through in vitro observations of the impacts of TFA­containing serum on GMC proliferation and extracellular matrix (ECM) secretion in lipopolysaccharides (LPS)­induced rats. Rat GMC was cultured in vitro, using LPS to stimulate the proliferation of GMC and the secretion of ECM; meanwhile, TFA­containing serum (TFA­S) was used for the intervention. Methyl thiazolyl tetrazolium (MTT) assay was performed to test the proliferation of GMC; enzyme­linked immunosorbent assay (ELISA) was used to detect the expressions of fibronectin (FN) and collagen IV (Col­IV) in cell supernatant, flow cytometry was performed to detect the cell cycle, and reverse transcription-polymerase chain reaction was performed to detect the expression levels of matrix metalloproteinase 9 (MMP­9) mRNA and transforming growth factor ß1 (TGF­ß1) mRNA. The GMC proliferation and the expressions of FN and Col­IV in cell supernatant were significantly reduced after 24 and 48 h TFA­S intervention (P<0.05 or 0.01). A total of 48 h subsequent to the intervention, the proportion of GMC in the G1 phase and the relative expression of MMP­9 mRNA were significantly increased (P<0.05 or 0.01), however the proportion of GMC in S phase and the relative expression of TGF­ß1 mRNA were significantly reduced (P<0.05 or 0.01). TFA­S can inhibit LPS­induced GMC proliferation and ECM accumulation, and its roles are associated with regulating the cell cycle and the expression levels of TGF­ß1 and MMP­9.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[St] Status:In-Process
[do] DOI:10.3892/mmr.2017.7194


  9 / 197 MEDLINE  
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[PMID]:28597370
[Au] Autor:Park HY; Kim DH; Sivanesan I
[Ad] Endereço:Department of Bioresource Engineering, Sejong University, Seoul, South Korea.
[Ti] Título:Micropropagation of Ajuga species: a mini review.
[So] Source:Biotechnol Lett;39(9):1291-1298, 2017 Sep.
[Is] ISSN:1573-6776
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The genus Ajuga L., belonging to Lamiaceae family, is widespread. The demand for Ajuga species has risen sharply because of their medicinal, ornamental, and pharmacological properties. These wide-ranging plants are being rapidly depleted due to over-collection for ornamental and medicinal purposes, as well as by habitat destruction and deforestation. Ajuga boninsimae, A. bracteosa, A. ciliate, A. genevensis, A. incisa, A. makinoi, A. multiflora, A. pyramidalis, A. shikotanensis, A. reptans, and A. vestita are categorized and protected as endangered plants. In vitro plant culture has therefore emerged for the conservation and mass clonal propagation of rare plants. This mini-review covers the current in vitro scenario in the propagation of Ajuga species. Adventitious or axillary shoots are initiated on the leaf, petiole and internodes, as well as roots, nodes, and shoot tip explants. Shoot induction is predominantly dependent on plant growth regulators added to the culture medium. Full- or half-strength Murashige and Skoog medium with or without auxin is used for in vitro rooting. Rooted shoots need to be acclimatized in the greenhouse with an estimated 82-100% survival rate.
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170805
[Lr] Data última revisão:
170805
[St] Status:In-Process
[do] DOI:10.1007/s10529-017-2376-4


  10 / 197 MEDLINE  
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[PMID]:28539822
[Au] Autor:Lin YT; Lin CC; Wang HC; Hsu YC
[Ad] Endereço:Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
[Ti] Título:Induction of Mitotic Delay in Pharyngeal and Nasopharyngeal Carcinoma Cells Using an Aqueous Extract of .
[So] Source:Int J Med Sci;14(5):462-469, 2017.
[Is] ISSN:1449-1907
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Nasopharyngeal carcinoma (NPC) is a common cancer in Southeast Asia, for which radiotherapy and/or chemotherapy are the primary treatment methods. Many herbs are known to have potential uses in chemotherapy; however, the mechanisms underlying the observed antitumor activity of (AB) against NPC remain unclear. We explored the antitumor effects of AB, which was shown specifically to induce mitotic delay in pharyngeal (Detroit 562) and nasopharyngeal (Hone-1) cancer cells. Proliferation of cancer cells after exposure to aqueous extract of (AEAB) was assessed using the MTT assay. DNA content and cell cycle arrest induction were analyzed using flow cytometry. The expression of checkpoint kinase 2 (CHK2), cell division control protein 2 (CDC2), and cyclin B1 was investigated using qRT-PCR and Western blot analysis. Results indicated the inhibition of cancer cell growth following exposure to AEAB. In addition, AEAB induced the accumulation of G /M-phase cells in cancer cell through the disassociation of CDC2/cyclin B1 complex. Our findings suggested that, in addition to the known effects of AEAB in NPC prevention, it may have antitumor activities against NPC cells. In conclusion, AEAB inhibits the growth of and induces mitotic delay in cancer cells, supporting its use as an anticancer agent.
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170528
[Lr] Data última revisão:
170528
[St] Status:In-Process
[do] DOI:10.7150/ijms.18154



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