Base de dados : MEDLINE
Pesquisa : cocaína [Palavras]
Referências encontradas : 27300 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2730 ir para página                         

  1 / 27300 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Lemos, Tadeu
Texto completo SciELO Brasil
[PMID]:29267663
[Au] Autor:Sordi MB; Massochin RC; Camargo AR; Lemos T; Munhoz EA
[Ad] Endereço:Universidade Federal de Santa Catarina - UFSC, Health Science Centre, Department of Stomatology, Florianópolis, SC, Brazil.
[Ti] Título:Oral health assessment for users of marijuana and cocaine/crack substances.
[So] Source:Braz Oral Res;31:e102, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to assess the oral health status of users of illicit drugs such as marijuana and cocaine/crack and compare it with individuals not using these chemical substances. Questionnaires were applied to 35 illicit drugs users to gather information on demographic status, general health, and use of drugs. Then, a clinical assessment of the oral health condition was performed to collect data on decayed, missing and filled teeth (DMFT) index, salivary flow rate (SFR), and mucosal lesions. The control group was composed of 35 non-illicit drug users. In the experimental group, 91.43% were males, 80% were smokers, and 42.85% were alcoholics. Cocaine was the most common drug used (77.15%), followed by marijuana (68.6%), and crack (51.4%). The average DMFT index was 9.8 and the SFR was reduced in 60% of subjects. Mucosal alterations were detected, but no potentially malignant disorders or oral cancer were diagnosed. Compared to control group, significantly higher values for gender (40%, p = 0.0001), smoking (22.86%) and heavy drinking (5.7%) habits (p = 0.0001), SFR (31.4%; p = 0.0308), and oral lesions (p = 0.0488) were found for the experimental group, although significantly higher values were found in the control group for DMFT index (p = 0.0148). It can be concluded that the use of illicit drugs contributed to an increased prevalence of oral mucosa lesions. In addition, a decline on SFR and a reduced DMFT index was observed for illicit drug users.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Cocaína/complicações
Abuso de Maconha/complicações
Doenças da Boca/induzido quimicamente
Mucosa Bucal/efeitos dos fármacos
Saúde Bucal/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Alcoolismo/complicações
Alcoolismo/epidemiologia
Estudos de Casos e Controles
Transtornos Relacionados ao Uso de Cocaína/epidemiologia
Estudos Transversais
Índice CPO
Feminino
Seres Humanos
Masculino
Abuso de Maconha/epidemiologia
Meia-Idade
Doenças da Boca/epidemiologia
Fatores de Risco
Salivação/efeitos dos fármacos
Taxa Secretória/efeitos dos fármacos
Distribuição por Sexo
Fumar/efeitos adversos
Fumar/epidemiologia
Fatores Socioeconômicos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  2 / 27300 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28456841
[Au] Autor:Blanco-Gandía MC; Aracil-Fernández A; Montagud-Romero S; Aguilar MA; Manzanares J; Miñarro J; Rodríguez-Arias M
[Ad] Endereço:Departamento de Psicobiología, Facultad de Psicología, Unidad de Investigación Psicobiología de las Drogodependencias, , Universitat de València, Avda. Blasco Ibáñez, 21, 46010, Valencia, Spain.
[Ti] Título:Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet.
[So] Source:Psychopharmacology (Berl);234(15):2337-2352, 2017 Aug.
[Is] ISSN:1432-2072
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Preclinical studies report that free access to a high-fat diet (HFD) alters the response to psychostimulants. OBJECTIVES: The aim of the present study was to examine how HFD exposure during adolescence modifies cocaine effects. Gene expression of CB1 and mu-opioid receptors (MOr) in the nucleus accumbens (N Acc) and prefrontal cortex (PFC) and ghrelin receptor (GHSR) in the ventral tegmental area (VTA) were assessed. METHODS: Mice were allowed continuous access to fat from PND 29, and the locomotor (10 mg/kg) and reinforcing effects of cocaine (1 and 6 mg/kg) on conditioned place preference (CPP) were evaluated on PND 69. Another group of mice was exposed to a standard diet until the day of post-conditioning, on which free access to the HFD began. RESULTS: HFD induced an increase of MOr gene expression in the N Acc, but decreased CB1 receptor in the N Acc and PFC. After fat withdrawal, the reduction of CB1 receptor in the N Acc was maintained. Gene expression of GHSR in the VTA decreased during the HFD and increased after withdrawal. Following fat discontinuation, mice exhibited increased anxiety, augmented locomotor response to cocaine, and developed CPP for 1 mg/kg cocaine. HFD reduced the number of sessions required to extinguish the preference and decreased sensitivity to drug priming-induced reinstatement. CONCLUSION: Our results suggest that consumption of a HFD during adolescence induces neurobiochemical changes that increased sensitivity to cocaine when fat is withdrawn, acting as an alternative reward.
[Mh] Termos MeSH primário: Cocaína/farmacologia
Dieta Hiperlipídica/psicologia
Dieta Hiperlipídica/tendências
Receptor CB1 de Canabinoide/biossíntese
Receptor CB1 de Canabinoide/genética
Recompensa
[Mh] Termos MeSH secundário: Animais
Condicionamento Clássico/efeitos dos fármacos
Condicionamento Clássico/fisiologia
Expressão Gênica
Masculino
Camundongos
Núcleo Accumbens/efeitos dos fármacos
Núcleo Accumbens/metabolismo
Córtex Pré-Frontal/efeitos dos fármacos
Córtex Pré-Frontal/metabolismo
Receptores de Grelina/metabolismo
Receptores Opioides mu/metabolismo
Reforço (Psicologia)
Área Tegmentar Ventral/efeitos dos fármacos
Área Tegmentar Ventral/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptor, Cannabinoid, CB1); 0 (Receptors, Ghrelin); 0 (Receptors, Opioid, mu); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE
[do] DOI:10.1007/s00213-017-4630-9


  3 / 27300 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28451642
[Au] Autor:Moschak TM; Carelli RM
[Ad] Endereço:Department of Psychology and Neuroscience, University of North Carolina, Chapel Hill, NC 27599.
[Ti] Título:Impulsive Rats Exhibit Blunted Dopamine Release Dynamics during a Delay Discounting Task Independent of Cocaine History.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The inability to wait for a large, delayed reward when faced with a small, immediate one, known as delay discounting, has been implicated in a number of disorders including substance abuse. Individual differences in impulsivity on the delay discounting task are reflected in differences in neural function, including in the nucleus accumbens (NAc) core. We examined the role of a history of cocaine self-administration, as well as individual differences in impulsivity, on rapid dopamine (DA) release dynamics in the NAc core. Rats with a history of cocaine or water/saline self-administration were tested on delay discounting while being simultaneously assayed for rapid DA release using electrochemical methods. In controls, we found that cue DA release was modulated by reward delay and magnitude, consistent with prior reports. A history of cocaine had no effect on either delay discounting or DA release dynamics. Nonetheless, independent of drug history, individual differences in impulsivity were related to DA release in the NAc core. First, high impulsive animals exhibited dampened cue DA release during the delay discounting task. Second, reward delay and magnitude in high impulsive animals failed to robustly modulate changes in cue DA release. Importantly, these two DAergic mechanisms were uncorrelated with each other and, together, accounted for a high degree of variance in impulsive behavior. Collectively, these findings demonstrate two distinct mechanisms by which rapid DA signaling may influence impulsivity, and illustrate the importance of NAc core DA release dynamics in impulsive behavior.
[Mh] Termos MeSH primário: Cocaína/administração & dosagem
Desvalorização pelo Atraso/efeitos dos fármacos
Dopamina/metabolismo
Comportamento Impulsivo
Núcleo Accumbens/efeitos dos fármacos
Núcleo Accumbens/metabolismo
[Mh] Termos MeSH secundário: Animais
Condicionamento Operante
Masculino
Ratos Long-Evans
Recompensa
Autoadministração
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
I5Y540LHVR (Cocaine); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  4 / 27300 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Laranjeira, Ronaldo R
Registro de Ensaios Clínicos
Texto completo
[PMID]:29251975
[Au] Autor:Miguel AQC; Madruga CS; Cogo-Moreira H; Yamauchi R; Simões V; Ribeiro A; da Silva CJ; Fruci A; McDonell M; McPherson S; Roll JM; Laranjeira RR
[Ad] Endereço:National Institute of Policies on Alcohol and Drugs (INPAD).
[Ti] Título:Contingency management targeting abstinence is effective in reducing depressive and anxiety symptoms among crack cocaine-dependent individuals.
[So] Source:Exp Clin Psychopharmacol;25(6):466-472, 2017 12.
[Is] ISSN:1936-2293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although contingency management (CM) is effective in promoting abstinence and treatment retention among crack cocaine users who meet the criteria for cocaine dependence, less is known about its off-target effects. In this secondary analysis, we evaluated the impact of CM on depressive and anxiety symptoms in a sample of cocaine-dependent individuals under treatment. Sixty-five crack cocaine users who met the criteria for cocaine dependence were randomly assigned to receive 12 weeks of standard treatment alone (STA; n = 32) or 12 weeks of standard treatment plus CM (STCM; n = 33). The outcome measures of the secondary analysis were depressive and anxiety symptoms assessed with the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI). At baseline, 59 (90.8%) of the participants reported at least mild depressive symptoms and 47 (72.5%) reported at least mild anxiety symptoms. The mean BDI-II (24.5 ± 12.1) and BAI (20.7 ± 13.5) scores in the sample as a whole was moderate. After treatment, the reported levels of depressive symptoms (ß = -9.6, p < .05) and anxiety symptoms (ß = -9.9, p < .05) were lower among the individuals receiving STCM than among those receiving STA. This study provides evidence that an STCM intervention targeting crack cocaine abstinence also produces significant reductions in depressive and anxiety symptoms. This low cost intervention also demonstrated significant promise and optimization potential for crack cocaine users in a setting of scarce resources and high mental health comorbidity. Relevance Statement: We found that the prevalence of depressive and anxiety symptoms were extremely high among crack cocaine users, and that, among such individuals, contingency management (CM) reduced depressive and anxiety symptomatology to a greater degree than did standard treatment. Our results suggest that CM targeting crack cocaine abuse can have off-target effects on psychiatric symptomatology. (PsycINFO Database Record
[Mh] Termos MeSH primário: Ansiedade/etiologia
Transtornos Relacionados ao Uso de Cocaína/complicações
Cocaína Crack
Depressão/etiologia
Psicoterapia de Grupo/métodos
Reforço (Psicologia)
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Escalas de Graduação Psiquiátrica
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Crack Cocaine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180224
[Lr] Data última revisão:
180224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1037/pha0000147


  5 / 27300 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29339724
[Au] Autor:Calipari ES; Godino A; Peck EG; Salery M; Mervosh NL; Landry JA; Russo SJ; Hurd YL; Nestler EJ; Kiraly DD
[Ad] Endereço:Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[Ti] Título:Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine.
[So] Source:Nat Commun;9(1):9, 2018 01 16.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation to seek and take the drug. There are currently no clinically available pharmacotherapies to treat cocaine addiction. Through a broad screen of innate immune mediators, we identify granulocyte-colony stimulating factor (G-CSF) as a potent mediator of cocaine-induced adaptations. Here we report that G-CSF potentiates cocaine-induced increases in neural activity in the nucleus accumbens (NAc) and prefrontal cortex. In addition, G-CSF injections potentiate cocaine place preference and enhance motivation to self-administer cocaine, while not affecting responses to natural rewards. Infusion of G-CSF neutralizing antibody into NAc blocks the ability of G-CSF to modulate cocaine's behavioral effects, providing a direct link between central G-CSF action in NAc and cocaine reward. These results demonstrate that manipulating G-CSF is sufficient to alter the motivation for cocaine, but not natural rewards, providing a pharmacotherapeutic avenue to manipulate addictive behaviors without abuse potential.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Transtornos Relacionados ao Uso de Cocaína/tratamento farmacológico
Cocaína/farmacologia
Fator Estimulador de Colônias de Granulócitos/metabolismo
Plasticidade Neuronal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Comportamento Aditivo/tratamento farmacológico
Comportamento Aditivo/fisiopatologia
Cocaína/administração & dosagem
Transtornos Relacionados ao Uso de Cocaína/fisiopatologia
Condicionamento Operante
Fator Estimulador de Colônias de Granulócitos/administração & dosagem
Fator Estimulador de Colônias de Granulócitos/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Núcleo Accumbens/efeitos dos fármacos
Núcleo Accumbens/metabolismo
Ratos
Ratos Sprague-Dawley
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
143011-72-7 (Granulocyte Colony-Stimulating Factor); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-01881-x


  6 / 27300 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27776677
[Au] Autor:Jarlais DC; Arasteh K; Feelemyer J; McKnight C; Barnes DM; Tross S; Perlman DC; Campbell AN; Cooper HL; Hagan H
[Ad] Endereço:Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: ddesjarlais@chpnet.org.
[Ti] Título:From Long-Term Injecting to Long-Term Non-Injecting Heroin and Cocaine Use: The Persistence of Changed Drug Habits.
[So] Source:J Subst Abuse Treat;71:48-53, 2016 12.
[Is] ISSN:1873-6483
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Transitioning from injecting to non-injecting routes of drug administration can provide important individual and community health benefits. We assessed characteristics of persons who had ceased injecting while continuing to use heroin and/or cocaine in New York City. METHODS: We recruited subjects entering Mount Sinai Beth Israel detoxification and methadone maintenance programs between 2011 and 2015. Demographic information, drug use histories, sexual behaviors, and "reverse transitions" from injecting to non-injecting drug use were assessed in structured face-to-face interviews. There were 303 "former injectors," operationally defined as persons who had injected at some time in their lives, but had not injected in at least the previous 6 months. Serum samples were collected for HIV and HCV testing. RESULTS: Former injectors were 81% male, 19% female, 17% White, 43% African-American, and 38% Latino/a, with a mean age of 50 (SD=9.2), and were currently using heroin and/or cocaine. They had injected drugs for a mean of 14 (SD=12.2) years before ceasing injection, and a mean of 13 (SD=12) years had elapsed since their last injection. HIV prevalence among the sample was 13% and HCV prevalence was 66%. The former injectors reported a wide variety of reasons for ceasing injecting. Half of the group appeared to have reached a point where relapse back to injecting was no longer problematic: they had not injected for three or more years, were not deliberately using specific techniques to avoid relapse to injecting, and were not worried about relapsing to injecting. CONCLUSIONS: Former injectors report very-long term behavior change toward reduced individual and societal harm while continuing to use heroin and cocaine. The behavior change appears to be self-sustaining, with full replacement of an injecting route of drug administration by a non-injecting route of administration. Additional research on the process of long-term cessation of injecting should be conducted within a "combined prevention and care" approach to HIV and HCV infection among persons who use drugs.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Cocaína/epidemiologia
Dependência de Heroína/epidemiologia
Comportamento de Redução do Risco
Abuso de Substâncias por Via Intravenosa/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Cidade de Nova Iorque/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  7 / 27300 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29393308
[Au] Autor:Farrell CM; Cucu DF
[Ad] Endereço:Resident Physician, Northwestern University.
[Ti] Título:Cocaine-Related Acute Spinal Cord Infarction.
[So] Source:R I Med J (2013);101(1):28-29, 2018 Feb 02.
[Is] ISSN:2327-2228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report a rare case of anterior spinal artery syndrome in the setting of acute cocaine use. A 31-year-old man presented to the hospital unarousable with leukocytosis and a positive toxicology screen for opioids, cocaine, benzodiazepines and cannabis. He was placed on intravenous naloxone. As the patient regained consciousness, he was found to have paraplegia, sensory loss below the level of T5, and urinary retention. MRI findings showed a signal intensity abnormality from the level of T1-4, highly suggestive of an acute ischemic spinal cord infarct. [Full article available at http://rimed.org/rimedicaljournal-2018-02.asp].
[Mh] Termos MeSH primário: Síndrome da Artéria Espinal Anterior/induzido quimicamente
Transtornos Relacionados ao Uso de Cocaína/complicações
Cocaína/toxicidade
Drogas Ilícitas/toxicidade
[Mh] Termos MeSH secundário: Adulto
Síndrome da Artéria Espinal Anterior/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Street Drugs); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


  8 / 27300 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29061385
[Au] Autor:Hofford RS; Prendergast MA; Bardo MT
[Ad] Endereço:Department of Psychology, University of Kentucky, Lexington, KY, 40536, USA. Electronic address: rebecca.hofford@uky.edu.
[Ti] Título:Modified single prolonged stress reduces cocaine self-administration during acquisition regardless of rearing environment.
[So] Source:Behav Brain Res;338:143-152, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Until recently, there were few rodent models available to study the interaction of post-traumatic stress disorder (PTSD) and drug taking. Like PTSD, single prolonged stress (SPS) produces hypothalamic-pituitary-adrenal (HPA) axis dysfunction and alters psychostimulant self-administration. Other stressors, such as isolation stress, also alter psychostimulant self-administration. However, it is currently unknown if isolation housing combined with SPS can alter the acquisition or maintenance of cocaine self-administration. The current study applied modified SPS (modSPS; two hours restraint immediately followed by cold swim stress) to rats raised in an isolation condition (Iso), enrichment condition (Enr), or standard condition (Std) to measure changes in cocaine self-administration and HPA markers. Regardless of rearing condition, rats exposed to modSPS had greater corticosterone (CORT) release and reduced cocaine self-administration during initial acquisition compared to non-stressed controls. In addition, during initial acquisition, rats that received both Iso rearing and modSPS showed a more rapid increase in cocaine self-administration across sessions compared to Enr and Std rats exposed to modSPS. Following initial acquisition, a dose response analysis showed that Iso rats were overall most sensitive to changes in cocaine unit dose; however, modSPS had no effect on the cocaine dose response curve. Further, there was no effect of either modSPS or differential rearing on expression of glucocorticoid receptor (GR) in hypothalamus, medial prefrontal cortex, amygdala, or nucleus accumbens. By using modSPS in combination with Iso housing, this study identified unique contributions of each stressor to acquisition of cocaine self-administration.
[Mh] Termos MeSH primário: Cocaína/administração & dosagem
Corticosterona/sangue
Inibidores da Captação de Dopamina/administração & dosagem
Receptores de Glucocorticoides/metabolismo
Isolamento Social
Estresse Psicológico/sangue
[Mh] Termos MeSH secundário: Tonsila do Cerebelo/efeitos dos fármacos
Tonsila do Cerebelo/metabolismo
Animais
Abrigo para Animais
Masculino
Núcleo Accumbens/efeitos dos fármacos
Núcleo Accumbens/metabolismo
Córtex Pré-Frontal/efeitos dos fármacos
Córtex Pré-Frontal/metabolismo
Ratos
Ratos Sprague-Dawley
Restrição Física
Autoadministração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dopamine Uptake Inhibitors); 0 (Receptors, Glucocorticoid); I5Y540LHVR (Cocaine); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE


  9 / 27300 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28466092
[Au] Autor:Montagud-Romero S; Nuñez C; Blanco-Gandia MC; Martínez-Laorden E; Aguilar MA; Navarro-Zaragoza J; Almela P; Milanés MV; Laorden ML; Miñarro J; Rodríguez-Arias M
[Ad] Endereço:Department of Psychobiology, Facultad de Psicología, Universitat de Valencia, Avda. Blasco Ibáñez, 21, 46010, Valencia, Spain.
[Ti] Título:Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB receptor in the mesolimbic system.
[So] Source:Psychopharmacology (Berl);234(13):2063-2075, 2017 Jul.
[Is] ISSN:1432-2072
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Repeated social defeat (RSD) increases the rewarding effects of cocaine in adolescent and adult rodents. OBJECTIVE: The aim of the present study was to compare the long-term effects of RSD on the conditioned rewarding effects of cocaine and levels of the transcription factors Pitx3 and Nurr1 in the ventral tegmental area (VTA), the dopamine transporter (DAT), the D2 dopamine receptor (D2DR) and precursor of brain-derived neurotrophic factor (proBDNF) signaling pathways, and the tropomyosin-related kinase B (TrkB) receptor in the nucleus accumbens (NAc) in adult and adolescent mice. METHODS: Male adolescent and young adult OF1 mice were exposed to four episodes of social defeat and were conditioned 3 weeks later with 1 mg/kg of cocaine. In a second set of mice, the expressions of the abovementioned dopaminergic and proBDNF and TrkB receptor were measured in VTA and NAc, respectively. RESULTS: Adolescent mice experienced social defeats less intensely than their adult counterparts and produced lower levels of corticosterone. However, both adult and adolescent defeated mice developed conditioned place preference for the compartment associated with this low dose of cocaine. Furthermore, only adolescent defeated mice displayed diminished levels of the transcription factors Pitx3 in the VTA, without changes in the expression of DAT and D2DR in the NAc. In addition, stressed adult mice showed a decreased expression of proBDNF and the TrkB receptor, while stressed adolescent mice exhibited increased expression of latter without changes in the former. CONCLUSION: Our findings suggest that dopaminergic pathways and proBDNF signaling and TrkB receptors play different roles in social defeat-stressed mice exposed to cocaine.
[Mh] Termos MeSH primário: Fator Neurotrófico Derivado do Encéfalo/fisiologia
Encéfalo/metabolismo
Cocaína/farmacologia
Condicionamento Clássico/efeitos dos fármacos
Corticosterona/metabolismo
Glicoproteínas de Membrana/metabolismo
Núcleo Accumbens/efeitos dos fármacos
Precursores de Proteínas/fisiologia
Receptor trkB/metabolismo
Receptores de Dopamina D2/metabolismo
Fatores de Transcrição/metabolismo
Área Tegmentar Ventral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Encéfalo/fisiologia
Fator Neurotrófico Derivado do Encéfalo/química
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Condicionamento Clássico/fisiologia
Corticosterona/química
Dopamina/metabolismo
Masculino
Glicoproteínas de Membrana/química
Camundongos
Precursores de Proteínas/química
Receptor trkB/química
Receptores de Dopamina D2/química
Recompensa
Estresse Psicológico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (DRD2 protein, human); 0 (Membrane Glycoproteins); 0 (Protein Precursors); 0 (Receptors, Dopamine D2); 0 (Transcription Factors); 0 (brain-derived neurotrophic factor precursor); EC 2.7.10.1 (Receptor, trkB); EC 2.7.10.1 (tropomyosin-related kinase-B, human); I5Y540LHVR (Cocaine); VTD58H1Z2X (Dopamine); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s00213-017-4612-y


  10 / 27300 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28993024
[Au] Autor:Parolini M; Bini L; Magni S; Rizzo A; Ghilardi A; Landi C; Armini A; Del Giacco L; Binelli A
[Ad] Endereço:Department of Environmental Science and Policy, University of Milan, via Celoria 2, I-20133 Milano, Italy. Electronic address: marco.parolini@unimi.it.
[Ti] Título:Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos.
[So] Source:Environ Pollut;232:603-614, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Illicit drugs have been identified as emerging aquatic pollutants because of their widespread presence in freshwaters and potential toxicity towards aquatic organisms. Among illicit drug residues, cocaine (COC) and its main metabolites, namely benzoylecgonine (BE) and ecgonine methyl ester (EME), are commonly detected in freshwaters worldwide at concentration that can induce diverse adverse effects to non-target organisms. However, the information of toxicity and mechanisms of action (MoA) of these drugs, mainly of COC metabolites, to aquatic species is still fragmentary and inadequate. Thus, this study was aimed at investigating the toxicity of two concentrations (0.3 and 1.0 µg/L) of COC, BE and EME similar to those found in aquatic ecosystems on zebrafish (Danio rerio) embryos at 96 h post fertilization through a functional proteomics approach. Exposure to COC and both its metabolites significantly altered the protein profile of zebrafish embryos, modulating the expression of diverse proteins belonging to different functional classes, including cytoskeleton, eye constituents, lipid transport, lipid and energy metabolism, and stress response. Expression of vitellogenins and crystallins was modulated by COC and both its main metabolites, while only BE and EME altered proteins related to lipid and energy metabolism, as well as to oxidative stress response. Our data confirmed the potential toxicity of low concentrations of COC, BE and EME, and helped to shed light on their MoA on an aquatic vertebrate during early developmental period.
[Mh] Termos MeSH primário: Cocaína/toxicidade
Embrião não Mamífero/efeitos dos fármacos
Drogas Ilícitas/toxicidade
Proteínas de Peixe-Zebra/metabolismo
Peixe-Zebra/embriologia
[Mh] Termos MeSH secundário: Animais
Cocaína/análogos & derivados
Cocaína/metabolismo
Embrião não Mamífero/fisiologia
Água Doce
Oxirredução
Estresse Oxidativo/efeitos dos fármacos
Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Street Drugs); 0 (Zebrafish Proteins); 5353I8I6YS (benzoylecgonine); I5Y540LHVR (Cocaine); Y35FJB3QBJ (ecgonine methyl ester)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE



página 1 de 2730 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde